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Curriculum Vita ERIC J. NESTLER Home Address: 201 East 80 Street, Apt 14G New York, NY 10075 Tele: 917-587-1499 Business Address: Department of Neuroscience Mount Sinai School of Medicine One Gustave Levy Place, Box 1065 New York, NY 10029-6574 Tele: 212-659-5656 Email: eric.nestler@mssm.edu

Website: http://neuroscience.mssm.edu/nestler/ Date of Birth: July 8, 1954 Place of Birth: New York, New York

Marital Status: Married to Susan DeRenzo Nestler Children: David I. Nestler, born November, 1985 Matthew E. Nestler, born April, 1988 Jane D. Nestler, born June, 1990

Current Position: Nash Family Professor of Neuroscience Chair, Department of Neuroscience Director, Friedman Brain Institute Icahn School of Medicine at Mount Sinai

Memberships in American Association for the Advancement of Science (Fellow) Professional Societies: American College of Neuropsychopharmacology (Fellow) American PsychoPathological Association (Fellow) American Society for Biochemistry and Molecular Biology American Society for Pharmacology and Experimental Therapeutics College on Problems of Drug Dependence International Society for Neurochemistry Research Society on Alcoholism Society for Neuroscience

Medical licenses: Diplomate, American Board of Psychiatry and Neurology (certified 11/88) CT, 026509 TX, L5964 NY, 249527

Education: B.A. and M.S., Yale University, May 1976

Department of Molecular Biophysics and Biochemistry Summa Cum Laude

Ph.D., Yale University, May 1982 Department of Pharmacology, Dr. Paul Greengard, thesis advisor M.D., Yale University, May 1983 Alpha Omega Alpha

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Postgraduate Training: Postdoctoral Fellow, 11/82-6/83 Department of Pharmacology, Yale University School of Medicine Dr. Paul Greengard's laboratory Intern in Medicine and Psychiatry, 7/83-6/84 Departments of Medicine and Psychiatry, Harvard Medical School Massachusetts General, McLean, and Mount Auburn Hospitals Resident in Psychiatry, 7/84-6/87 Department of Psychiatry, Yale University School of Medicine Postdoctoral Fellow, 7/85-6/87 Department of Psychiatry, Yale University School of Medicine Dr. John F. Tallman's laboratory Academic Positions: Yale University School of Medicine (1987-2000) Assistant Professor of Psychiatry and Pharmacology, 7/87-6/91

Elizabeth Mears and House Jameson Assistant Professor, 7/89-6/91 Elizabeth Mears and House Jameson Associate Professor, 7/91-6/94

Director, Division of Molecular Psychiatry, 1/92-8/00 Tenured, 7/92 Director, Abraham Ribicoff Research Facilities, 7/92-8/00 Elizabeth Mears and House Jameson Professor, 7/94-8/00 Member, Medical Staff, Connecticut Mental Health Center, 1987-2000 Member, Medical Staff, Yale New Haven Hospital, 1995-2000 Joint Appointment, Department of Neurobiology, 7/97-8/00 Director, Yale Center for Genes and Behavior, 9/97-8/00 The University of Texas Southwestern Medical Center at Dallas (2000-2008) Lou and Ellen McGinley Distinguished Professor of Psychiatry Chair, Department of Psychiatry Professor of Neuroscience

Member, Medical Staff, Zale Lipshy University Hospital, Parkland Memorial Hospital, and Children’s Medical Center of Dallas

Mount Sinai School of Medicine (2008-present) Nash Family Professor of Neuroscience Chair, Department of Neuroscience Director, Friedman Brain Institute Member, Medical Staff, The Mount Sinai Medical Center

Honors: 1975 Publisher, Yale Daily News 1975 Elected to Phi Beta Kappa 1976 Elected Associate Member, Sigma Xi 1976 New Prize, Jonathan Edwards College, Yale University 1977 President, Medical School Class 1977-1981 Student Editor, Yale Journal of Biology and Medicine 1983 Elected to Alpha Omega Alpha Medical Honor Society 12/82-6/83 Junior Fellow, The Neurosciences Institute of the Neurosciences Research Program, The Rockefeller University 1986 Mead-Johnson Travel Award American College of Neuropsychopharmacology 1987 Laughlin Fellow, American College of Psychiatry 1987 Seymour Lustman Award, Department of Psychiatry Yale University School of Medicine 1987-1989 Pfizer Scholar Award, Pfizer Scholars Program for New Faculty

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1987-1989 Research Fellow, Alfred P. Sloan Foundation 1989-1992 McKnight Scholar Award The McKnight Endowment Fund for Neuroscience 1989 Named to an Endowed Faculty Position, Yale University 1990 Jordi Folch-Pi Young Investigator Award American Society of Neurochemistry 1990 Pharmacology Young Investigator Award Lilly Research Laboratories, Eli Lilly 1993 Judith Silver Memorial Young Scientist Award National Alliance for the Mentally Ill 1993 Symposium Chair, "Molecular Plasticity to Psychotropic Drugs" 1993 Annual Meeting of the Society for Neuroscience 1993 Plenary Lecturer, 1993 Annual Meeting of the American College of Neuropsychopharmacology 1994 Efron Award American College of Neuropsychopharmacology 1995 1995 Symposium on the Frontiers of Science National Academy of Sciences (Washington, DC) 1996 Established Investigator Award National Alliance for Research on Schizophrenia and Depression 1996 Co-Chair, Program Committee American College of Neuropsychopharmacology 1997 Stanley Marsh III Endowed Visiting Professorship Texas Tech University 1997 MERIT Award, National Institute on Drug Abuse 1997 Elected to Scientific Council, National Alliance for Research on Schizophrenia and Depression 1998 Chair, Program Committee American College of Neuropsychopharmacology 1998 Robert J. and Claire Pasarow Foundation Award for Neuropsychiatric Research 1998 Karolinska Research Lecture at Nobel Forum 1998 Elected to the Institute of Medicine of the National Academies 1999 Elected to the Connecticut Academy of Science and Engineering 1999 Elected Fellow, American College of Neuropsychopharmacology 1999 Co-Chair, Conference on Drug Addiction Juan March Foundation, Madrid 2000 Special Lecture, 30th Annual Meeting Society for Neuroscience 2000 Pfizer Visiting Professor in Psychiatry UMDNJ Robert Wood Johnson Medical School 2001 Plenary Lecturer, 2001 Annual Meeting of the American College of Neuropsychopharmacology

2002 Elected Council Member American College of Neuropsychopharmacology 2002 Elected Council Member Society for Neuroscience 2002 Basic Neuroscience Award Collegium Internationale Neuro-Psychopharmacologicum 2003 Edward J. Sachar Award, Columbia University 2004 Bristol-Myers Squibb Freedom to Discover Award 2004 Elected Fellow American Association for the Advancement of Science 2004 Elected Member Texas Academy of Science, Engineering, and Medicine 2004 Gill Center Award for Biomolecular Science Indiana University

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2005 Elected Fellow American Academy of Arts and Sciences 2005 Elected Member The Dana Alliance for Brain Initiatives 2006 Plenary Lecturer, 2006 Annual Meeting of the American College of Neuropsychopharmacology 2006 Teaching Award, UT Southwestern Medical Students 2007 Lifetime Achievement Award, Texas Research Society on Alcoholism

2008 Fondation Ipsen Prize in Neuronal Plasticity (shared with Jean-Pierre Changeux and Peter Kalivas) 2008 Patricia S. Goldman-Rakic Prize for Neuroscience Research, National Alliance for Research in Schizophrenia and Depression 2009 Falcone Prize for Mood Disorders Research, National Alliance for Research in Schizophrenia and Depression 2009 Julius Axelrod Prize for Mentorship American College of Neuropsychopharmacology (shared with Dennis Charney) 2010-2011 President-Elect (2010), President (2011) American College of Neuropsychopharmacology 2010 Ray Fuller Lecture, American Society for Pharmacology and Experimental Therapeutics 2010 Rhoda and Bernard Sarnat International Prize in Mental Health Institute of Medicine (shared with Charles O’Brien) 2011 Honorary Doctorate, Pharmaceutical Sciences, Uppsala University 2012 Anna Monika Prize in Depression Research 2013 Gold Medal Award, Society of Biological Psychiatry 2014 Scientific Achievement Award, Miami Winter Symposium 2015 Edward J. Ronan Teaching Award, Mount Sinai Student Council 2015 Best Mentor Award, Mount Sinai Postdoctoral Council 2015 Elected President, Society for Neuroscience (President 2017)

Consultative Activities: Manson Youth Institution, Consulting Psychiatrist, 1985-1996 Yale Faculty Practice Plan, Consulting Psychiatrist, 1987-2000 OCD Foundation, Board of Trustees member, 1988-2004 Pfizer Pharmaceuticals, Consulting Scientist, 1991-2000 Neurogen Corporation, Scientific Advisory Board member, 1993-2007 International Anti-Drug Abuse Foundation, Board of Directors member, 1994-2004 Pharmacia, Consulting Scientist, 1998-2002 PsychoGenics, Founder and Chairman, Scientific Advisory Board, 1998-present Wyeth-Ayerst, Project Scientific Advisory Board, 2000-2002 Helicon, Scientific Advisory Board, 2001-2007 Global Genomics, Scientific Advisory Board, 2002-2004 RxGen, Scientific Advisory Board, 2002-2008 Novartis, Consulting Scientist, 2003 Intra-Cellular Therapies, Scientific Advisory Board, 2003-present Neurologix, Scientific Advisory Board, 2004-2012 Eli Lilly, Consulting Scientist, 2004-2007 Epix Pharmaceuticals, Scientific Advisory Board, 2005-2008 Psylin Neurosciences, Scientific Advisory Board, 2007-2008 Merck Research Laboratory, Consulting Scientist, 2008-present Johnson & Johnson, Consulting Scientist, 2008-present Berg Pharma, Consulting Scientist, 2012-present

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Editorial Board Membership: Yale Journal of Biology and Medicine, 1987-1991 Journal of Neurochemistry, 1991-1997 Yale Psychiatry, Editor-in-Chief, 1991-1997 Neuropsychopharmacology, 1993-1996, 2002-2005 The Neuroscientist, Associate Editor, 1994-2002 The Journal of Neuroscience, Associate Editor, 1995-2002 Neuron, Associate Editor, 1995-present Molecular Pharmacology, Associate Editor, 1995-2004 Archives of General Psychiatry, Associate Editor, 1995-2000 Biochemical Pharmacology, Associate Editor, 1996-2002 Synapse, Editorial Board Member, 1996-2004 Biological Psychiatry, Deputy Editor, 1997-present Molecular Neurobiology, Editorial Advisory Board member, 1997-present Current Drug Targets, CNS and Neurological Disorders, Editorial Advisory Board member, 2000-present NeuroMolecular Medicine, Editorial Board member, 2001-present Faculty of 1000, 2001-2014 Current Opinion in Neurobiology, Editorial Board member, 2003-present Public Library of Science - Biology, Editorial Board member, 2003-present

Advisory/Peer Review Experience:

Ad hoc reviewer of biomedical National Science Foundation grants, 1987-present Member, Biochemistry Study Section, National Institute on Drug Abuse, 1991-1995 Ad hoc member of special review committees, National Institute on Drug Abuse, National Institute of Mental Health, National Academy of Sciences, 1991-present Special review consultant, Medical Research Council of Ontario, Canada, 1991-2000 Member, NIDA Medications Development Committee, Institute of Medicine, National Academy of Sciences, 1993-1995 Member, Opportunities in Drug Abuse Research Committee, Institute of Medicine, National Academy of Sciences, 1995-1996 Member, Program Committee, American College of Neuropsychopharmacology, 1995-1999 (Committee Co-Chair, 1996; Committee Chair, 1998) Member, Board of Scientific Counselors, National Institute on Drug Abuse, 1995-2001, Chair, 1999-2001 Member, Program Committee, Society for Neuroscience, 1997-1999 National Alliance for Autism Research (NAAR), Scientific Council member, 1994-2008 National Alliance for Research on Schizophrenia and Depression (NARSAD), Scientific Council member, 1997-present Member, Science Advisory Committee (sponsored by CPDD) to the Director, Office of National Drug Control Policy, 1998-2004 Member, Honorific Awards Committee, American College of Neuropsychopharmacology, 1999 Member, Public Information Committee, Society for Neuroscience, 1999-2002 Member, Scientific Review Committee, The McKnight Endowment Fund for Neuroscience, 2000-2013 (Chair, 2008-2013) Chair, Nominating Committee, American College of Neuropsychopharmacology, 2000 Member, Academic Advisory Board, Pfizer Postdoctoral Fellowship in Biological Psychiatry, 2002-2004 Member, National Advisory Mental Health Council, National Institute of Mental Health, 2002-2005 Member, Board of Directors, The McKnight Endowment Fund for Neuroscience, 2002-2013 Member, Council, American College of Neuropsychopharmacology, 2002-2005 Member, Scientific Advisory Board, National Depressive Manic-Depressive Association, 2002-present Member, Council, Society for Neuroscience, 2002-2006 Member, Jacob P. Waletzky Award Selection Committee Chair, Society for Neuroscience, 2003-2004 Member, Scientific Advisory Board, Medication Development Division, National Institute on Drug Abuse, 2005-1008 Member, Scientific Advisory Board, Depression and Bipolar Support Alliance, 2005-present Member, Board of Directors, The National Foundation for Mental Health, 2005-present

Member, The Dana Alliance for Brain Initiatives, 2006-present

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Member, Board of Directors, Mental Health America of Greater Dallas, 2006-2008 Member, Committee on Committees, Society for Neuroscience, 2007-2009 Member, Scientific Advisory Board, Bachmann-Strauss Dystonia and Parkinson Foundation, 2009-present Member, Scientific Advisory Board, International Rett Syndrome Foundation, 2009-present

Member, Scientific Advisory Board, Autism Speaks, 2009-present Chair, Scientific Advisory Board, International Mental Health Research Organization, 2009-present

President, American College of Neuropsychopharmacology, President Elect 2010, President 2011, Past President 2012 Member, Scientific Advisory Council, Hope for Depression Research Foundation, 2011-present Chair, Scientific Advisory Board, Tau Consortium, 2012-present Member, Membership Committee, Institute of Medicine, 2013-2016 (Co-Chair 2013-2014, Chair 2015-2016) Member, Scientific Advisory Board, Simons Foundation Autism Research Initiative, 2014-present President, Society for Neuroscience, President Elect 2016, President 2017, Past President 2018 Grant Support History:

Active: R01 DA007359 (Nestler) 8/91-3/16 NIDA, Molecular Studies of Cocaine Action in Brain The goal of this project is to study the role of ∆FosB and its target genes in the long-term actions of cocaine and other drugs of abuse on the brain. P50 MH096890 (Nestler) 7/12-6/17 NIMH, Epigenetic Mechanisms of Depression The major goal of this multi-project grant is to explore the role of chromatin modifications within the brain’s limbic circuitry in animal models of stress and depression. The major components of this Center grant are: Animal Models Core (Dr. Nestler is Core PI) Chromatin and Gene Analysis Core (Dr. Nestler is Core PI) Project 1: Repressive Histone and DNA Methylation in Rodent Depression Models (Dr. Nestler is Project PI) Project 2: Methyl-Binding Proteins in Rodent Depression Models (Schahram Akbarian, PI) Project 3: Histone Variants in Rodent Depression Models (David Allis, PI) Project 4: Epigenetic Mechanisms of Depression in Human Limbic Circuits (Carol Tamminga, PI) P01 DA008227 (Nestler) 8/92-12/18 NIDA, Molecular Neurobiology of Drug Addiction This PPG supports a series of highly interactive and multidisciplinary studies aimed at delineating the molecular and cellular mechanisms underlying opiate and cocaine addiction. The major components of this program project grant are: Animal Models Core (Vanna Zachariou, PI) Chromatin and Gene Analysis Core (Dr. Nestler is Core PI) Project 1: Role of CREB in opiate and cocaine addiction (Dr. Nestler is Project PI) Project 2: Cellular studies of drug action (Robert Malenka, PI) Project 3: Neurobiology of drug reward and relapse (David Self, PI) Project 4: Neurobiology of human addiction (Yasmin Hurd, PI) R01 MH051399 (Nestler) 5/99-4/19 NIMH, Pharmacological Actions of Stress & Antidepressants Treatments The goal of this project is to characterize the role of ∆FosB and its target genes in mediating the long-term actions of stress and antidepressant treatments on the brain. R01 DA014133 (Nestler) 9/00-6/20 NIDA, Role of Neurotrophic Factors in the Actions of Drugs of Abuse The major goals of this project are to study the modulation of the biochemical and behavioral actions of drugs of abuse in the mesolimbic dopamine system by neurotrophic factors.

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Completed: RC1 MH088477 (Nestler) 9/09-8/11 NIMH Screening for Small Molecule Activators of ∆FosB This grant represented a collaborative effort with Gabby Rudenko at the University of Michigan who identified and characterized small molecular modulators of ∆FosB. Dr. Nestler then studied lead molecules in cell culture and in vivo. P50 MH66172 (Nestler) 9/02-7/12 NIMH, Neural Substrates of Appetitive Behavior in Mood and Motivation The goal of this multi-project grant is to explore the role of the brain’s reward pathways (particularly the nucleus accumbens and hypothalamus) in the regulation of normal mood and in animal models of stress and depression. The major components of this Center grant are: Transgenic Core (Dr. Nestler is Core PI) Behavioral Core (Dr. Nestler is Core PI) Chromatin and Gene Regulation Core (Dr. Nestler is Core PI) Project 1: Role of CREB in VTA-NAc in regulating mood and motivation (Dr. Nestler is Project PI) Project 2: Role of BDNF signaling in VTA-NAc in regulating mood (Luis Parada, PI) Project 3: Role of hypothalamic feeding peptides in VTA-NAc in regulating mood (Masashi Yanagisawa, PI) Project 4: Role of circadian genes in VTA-NAc in regulating mood (Steve McKnight, PI) Project 5: Molecular targets for depression in human reward circuits (Carol Tamminga, PI) P50 MH090963 (Paul Greengard) 8/10-7/15 NIMH, Identification of Cell Type-Specific Actions of Antipsychotic Drugs This Center contributes to our understanding of the role played by specific subtypes of striatal and prefrontal cortical neurons in mediating the long-term actions of antipsychotic drugs. Dr. Nestler’s project focuses on changes induced by such drugs on chromatin modifications in striatal and prefrontal cortical limbic circuits.

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PUBLICATIONS Books 1. Nestler, E.J. and Greengard, P. (1984) Protein Phosphorylation in the Nervous System, J. Wiley & Sons, New York. 2. Hyman, S.E. and Nestler, E.J. (1993) The Molecular Foundations of Psychiatry, American Psychiatric Press, Washington, D.C. 3. Goldstein, A. and Nestler, E.J. (Eds.) (1998) Special Issue: Neurobiology of Addiction. Drug and Alcohol Dependence, vol. 51, numbers 1 and 2. 4. Rosenberg, R.N., DiMauro, S., Paulson, H.L., Ptacek, L., and Nestler, E.J. (Eds.) (2008) The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 4th Ed, Lippincott, Williams and Wilkins, New York. (3rd edition published in 2003.) 5. Charney, D.S., Buxbaum, J.D., Sklar, P., and Nestler, E.J. (Eds.) (2013) Neurobiology of Mental Illness, 4th Ed., Oxford University Press, New York. (1st edition published in 1999, 2nd ed. in 2003, 3rd ed. in 2009.) 6. Sweatt, J.D., Meaney, M.J., Nestler, E.J., and Akbarian, S. (2013) Epigenetic Regulation in the Nervous System. Academic Press, New York. 7. Nestler, E.J., Hyman, S.E., and Malenka, R.C (2015) Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 2nd Ed., McGraw-Hill, New York. (1st edition published in 2001.) Original research articles 1. Beam, K.G., Nestler, E.J., and Greengard, P. (1977) Increased cyclic GMP levels associated with contraction in muscle fibers of the giant barnacle. Nature 267:534-536. 2. Nestler, E.J., Beam, K.G., and Greengard, P. (1978) Nicotinic cholinergic stimulation increases cyclic GMP levels in vertebrate skeletal muscle. Nature 275:451-453. 3. Nestler E.J. and Greengard, P. (1980) Dopamine and depolarizing agents regulate the state of phosphorylation of Protein I in the mammalian superior cervical sympathetic ganglion. Proc. Natl. Acad. Sci. USA 77:7479-7483. 4. Goelz, S.E., Nestler, E.J., Chehrazi, G., and Greengard, P. (1981) Distribution of Protein I in mammalian brain as determined by a detergent-based radioimmunoassay. Proc. Natl. Acad. Sci. USA 78:2130-2134. 5. Nestler, E.J., Rainbow, T.C., McEwen, B.S., and Greengard, P. (1981) Corticosterone increases the amount of Protein I, a neuron-specific phosphoprotein, in rat hippocampus. Science 212:1162-1164. 6. Nestler, E.J., and Greengard, P. (1982) Nerve impulses increase the phosphorylation state of Protein I in rabbit superior cervical ganglion. Nature 296:452-454.

7. Fried, G., Nestler, E.J., De Camilli, P., Stjarne, L., Olson, L., Lundberg, J.M., Hokfelt, T., Ouimet, C.C., and Greengard, P. (1982) Cellular and subcellular localization of Protein I in the peripheral nervous system. Proc. Natl. Acad. Sci. USA 79:2717-2721. 8. Nestler, E.J., Zatz, M., and Greengard, P. (1982) A diurnal rhythm in pineal Protein I levels mediated by β-adrenergic neurotransmission. Science 217:357-359. 9. Nestler, E.J. and Greengard, P. (1982) Distribution of Protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion. J. Neurosci. 2:1011-1023.

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10. Perdahl, E., Adolfsson, R., Alafuzoff, I., Albert, K.A., Nestler, E.J., Greengard, P., and Winblad, B. (1984) Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multi-infarct dementia. J. Neural Transmission 60:133-141. 11. Goelz, S.E., Nestler, E.J., and Greengard, P. (1985) Phylogenetic survey of Synapsin I-like proteins and biochemical analysis of four such proteins from fish brain. J. Neurochem. 45:63-72. 12. Sweetnam, P.M., Nestler, E.J., Gallombardo, P., Brown, S., Duman, R.S., Bracha, S., and Tallman, J.F. (1987) Comparison of the molecular structure of GABA/benzodiazepine receptors purified from rat and human cerebellum. Mol. Brain Res. 2:223-233. 13. Nestler, E.J. and Tallman, J.F. (1988) Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus. Mol. Pharmacol. 33:127-132. 14. Duman, R.S., Tallman, J.F., and Nestler, E.J. (1988) Acute and chronic opiate regulation of adenylate cyclase in brain: Specific effects in locus coeruleus. J. Pharmacol. Exp. Ther. 246:1033-1039. 15. Innis, R.B., Nestler, E.J., and Aghajanian, G.K. (1988) Evidence of G-protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Res. 459:27-36. 16. Sweetnam, P.M., Lloyd, J., Gallombardo, P., Gallager, D.W., Tallman, J.F., and Nestler, E.J. (1988) Phosphorylation of the GABAA/benzodiazepine receptor α subunit by a receptor-associated protein kinase. J. Neurochem. 51:1274-1284. 17. Bean, A.J., Shepard, P.D., Bunney, B.S., Nestler, E.J., and Roth, R.H. (1988) The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Mol. Pharmacol. 34:715-718. 18. Nestler, E.J., Erdos, J.J., Terwilliger, R., Duman, R.S., and Tallman, J.F. (1989) Regulation of G-proteins by chronic morphine in the rat locus coeruleus. Brain Res. 476:230-239. 19. Nestler, E.J., Terwilliger, R.Z., and Halm, E. (1989) Corticosterone increases protein tyrosine kinase activity in the locus coeruleus and other monoaminergic nuclei of rat brain. Mol. Pharmacol. 35:265-270. 20. Duman, R.S., Terwilliger, R., Nestler, E.J., and Tallman, J.F. (1989) Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain. Biochem. Pharmacol. 38:1909-1914. 21. Beitner, D., Duman, R.S., and Nestler, E.J. (1989) A novel action of morphine in the rat locus coeruleus: Persistent decrease in adenylate cyclase. Mol. Pharmacol. 35:559-564. 22. Saito, N., Guitart, X., Hayward, M., Tallman, J.F., Duman, R.S., and Nestler, E.J. (1989) Corticosterone differentially regulates the expression of Gsα and Giα messenger RNA and protein in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 86:3906-3910. 23. Nestler, E.J., Terwilliger, R.Z., and Beitner, D.B. (1989) Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus. Life Sci. 45:1073-1080. 24. Nestler, E.J., Terwilliger, R.Z., and Duman, R.S. (1989) Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J. Neurochem. 53:1644-1647. 25. Guitart, X. and Nestler, E.J. (1989) Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: Regulation by acute and chronic morphine. J. Neurosci. 9:4371-4387. 26. Winston, S.M., Hayward, M.D., Nestler, E.J., and Duman, R.S. (1990) Chronic electroconvulsive seizures down regulate expression of the c-fos proto-oncogene in rat cerebral cortex. J. Neurochem. 54:1920-1925. 27. Guitart, X. and Nestler, E.J. (1990) Identification of MARPP-14-20, morphine- and cyclic AMP-regulated phosphoproteins of 14-20 kD, as myelin basic proteins: Evidence for their acute and chronic regulation by morphine in rat brain. Brain Res. 516:57-65.

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28. Rasmussen, K., Beitner, D.B., Krystal, J.H., Aghajanian, G.K., and Nestler, E.J. (1990) Opiate withdrawal and the rat locus coeruleus: Behavioral, electrophysiological, and biochemical correlates. J. Neurosci. 10:2308-2317. 29. Guitart, X., Hayward, M., Nisenbaum, L.K., Beitner, D.B., Haycock, J.W., and Nestler, E.J. (1990) Identification of MARPP-58, a morphine- and cyclic AMP-regulated phosphoprotein of 58 kD, as tyrosine hydroxylase: Evidence for regulation of its expression by chronic morphine in the rat locus coeruleus. J. Neurosci. 10:2635-2645. 30. Hayward, M.D., Duman, R.S., and Nestler, E.J. (1990) Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain. Brain Res. 525:256-266. 31. Nestler, E.J., Terwilliger, R.Z., Walker, J., Sevarino, K.A., and Duman, R.S. (1990) Chronic cocaine decreases levels of the G-protein subunits Giα and Goα in discrete regions of rat brain. J. Neurochem. 55:1079-1082. 32. Nestler, E.J., McMahon, A., Sabban, E.L., Tallman, J.F., and Duman, R.S. (1990) Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus. Proc. Natl. Acad. Sci. USA 87:7522-7526. 33. Duman, R.S., Winston, S.M., Clark, J., and Nestler, E.J. (1990) Corticosterone regulates the expression of ADP-ribosylation factor (ARF) messenger RNA and protein in rat cerebral cortex. J. Neurochem. 55:1813-1816. 34. Terwilliger, R.Z., Beitner-Johnson, D., Sevarino, K.A., Crain, S.M., and Nestler, E.J. (1991) A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res. 548:100-110. 35. Beitner-Johnson, D. and Nestler, E.J. (1991) Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions. J. Neurochem. 57:344-347. 36. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. (1991) Dopaminergic brain reward regions of Lewis and Fischer rats display different levels of tyrosine hydroxylase and other morphine- and cocaine-regulated phosphoproteins. Brain Res. 561:146-149. 37. Lovenberg, T.W., Nichols, D.E., Nestler, E.J., Roth, R.H., and Mailman, R.B. (1991) Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: Role of D1-dopamine and muscarinic receptors. Brain Res. 556:101-107. 38. Kosten, T.A., Marby, D.W., and Nestler, E.J. (1991) Cocaine conditioned place preference is attenuated by chronic buprenorphine treatment. Life Sci. 49:201-206. 39. Duman, R.S., Terwilliger, R.Z., and Nestler, E.J. (1991) Endogenous ADP-ribosylation in brain: Initial characterization of substrate proteins. J. Neurochem. 57:2124-2132. 40. Colin, S.F., Chang, H.-C., Mollner, S., Pfeuffer, T., Reed, R.R., Duman, R.S., and Nestler, E.J. (1991) Chronic lithium regulates the expression of adenylate cyclase and Giα in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 88:10634-10637. 41. Campeau, S., Hayward, M.D., Hope, B.T., Rosen, J.B., Nestler, E.J., and Davis, M. (1991) Induction of the c-fos proto-oncogene in rat amygdala during unconditioned and conditioned fear. Brain Res. 565:349-352. 42. Rimland, J., Xin, W., Sweetnam, P., Saijoh, K., Nestler, E.J., and Duman, R.S. (1991) Sequence and expression of a neuropeptide Y receptor cDNA. Mol. Pharmacol. 40:869-875. 43. Melia, K.R., Rasmussen, K., Terwilliger, R.Z., Haycock, J.W., Nestler, E.J., and Duman, R.S. (1992) Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: Effects of chronic stress and drug treatments. J. Neurochem. 58:494-502. 44. Petzel, D., Ganz, M.B., Nestler, E.J., Lewis, J.J., Goldenring, J., Akcicek, F., and Hayslett, J.P. (1992) Correlates of aldosterone-induced increases in Ca2+

i and Isc suggest that Ca2+i is the second messenger for stimulation

of apical membrane conductance. J. Clin. Invest. 89:150-156.

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45. Guitart, X., Thompson, M.A., Mirante, C.K., Greenberg, M.E., and Nestler, E.J. (1992) Regulation of CREB phosphorylation by acute and chronic morphine in the rat locus coeruleus. J. Neurochem. 58:1168-1171. 46. Kogan, J.H., Nestler, E.J., and Aghajanian, G.K. (1992) Elevated basal firing rates of locus coeruleus neurons in brain slices from opiate-dependent rats: Association with enhanced responses to 8-Br-cAMP. Eur. J. Pharmacol. 211:47-53. 47. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. (1992) Neurofilaments and the mesolimbic dopamine system: Common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area. J. Neurosci. 12:2165-2176. 48. Vaccarino, F.M., Hayward, M.D., Nestler, E.J., Duman, R.S., and Tallman, J.F. (1992) Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons. Mol. Brain Res. 12:233-241. 49. Hope, B., Kosofsky, B., Hyman, S.E., and Nestler, E.J. (1992) Regulation of IEG expression and AP-1 binding by chronic cocaine in the rat nucleus accumbens. Proc. Natl. Acad. Sci. USA 89:5764-5768. 50. Melia, K.R., Nestler, E.J., and Duman, R.S. (1992) Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of chronically stressed rats. Psychopharmacology 108:23-26. 51. Guitart, X. and Nestler, E.J. (1992) Chronic administration of lithium or other antidepressants increases levels of DARPP-32 in rat frontal cortex. J. Neurochem. 59:1164-1167. 52. Guitart, X., Beitner-Johnson, X., Marby, D., Kosten, T.A., and Nestler, E.J. (1992) Fischer and Lewis rats strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system. Synapse 12:242-253. 53. Bergson, C., Zhao, H.-Q., Saijoh, K., Duman, R.S., and Nestler, E.J. (1993) Ezrin and osteonectin, two proteins associated with cell shape and growth, are enriched in the locus coeruleus. Mol. Cell. Neurosci. 4:64-73. 54. Guitart, X, Kogan, J.H., Berhow, M., Terwilliger, R.Z., Aghajanian, G.K., and Nestler, E.J. (1993) Lewis and Fischer rat strains display differences in biochemical, electrophysiological, and behavioral parameters: Studies in the nucleus accumbens and locus coeru1leus of drug naive and morphine-treated animals. Brain Res. 611:7-17. 55. Xin, W., Terwilliger, R.Z., Rimland, J., Wong, M.L., Nestler, E.J., and Duman, R.S. (1993) Characterization and functional expression of a somatostatin receptor coupled to adenylyl cyclase. Mol. Cell. Neurosci. 4:259-266. 56. Beitner-Johnson, D. and Nestler, E.J. (1993) Chronic morphine decreases IGF-1 levels in the ventral tegmental area of rat brain. Ann. N.Y. Acad. Sci. 692:246-248. 57. Vaccarino, F.M., Hayward, M.D., Le, H.N., Duman, R.S., and Nestler, E.J. (1993) Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex. Mol. Brain Res. 19:76-82. 58. Guitart, X., Lumeng, L., Li, T.-K., and Nestler, E.J. (1993) Alcohol preferring (P) and non-preferring (NP) rats display different levels of neurofilament proteins in the ventral tegmental area. Alcoholism: Clin. Exp. Res. 17:580-585. 59. Duman, R.S., Terwilliger, R.Z., and Nestler, E.J. (1993) Alterations in nitric oxide-stimulated endogenous ADP-ribosylation associated with long-term potentiation in rat hippocampus. J. Neurochem. 61:1542-1545. 60. Miserendino, M.J.D., Guitart, X., Terwilliger, R., Chi, S., and Nestler, E.J. (1993) Individual differences in locomotor activity are associated with levels of tyrosine hydroxylase and neurofilament proteins in the ventral tegmental area of Sprague Dawley rats. Mol. Cell. Neurosci. 4:440-448. 61. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. (1993) Glial fibrillary acidic protein and the mesolimbic dopamine system: Regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area. J. Neurochem. 61:1766-1773.

12

62. Beitner-Johnson, D. and Nestler, E.J. (1993) Chronic morphine impairs axoplasmic transport in the mesolimbic dopamine system of the rat brain. NeuroReport 5:57-60. 63. Trevisan, L., Fitzgerald, L.W., Brose, N., Gasic, G.P., Heinemann, S.F., Duman, R.S., and Nestler, E.J. (1994) Chronic ingestion of ethanol upregulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J. Neurochem. 62:1635-1638. 64. Kosten, T.A., Miserendino, M.J.D., Chi, S., and Nestler, E.J. (1994) Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization, but not in locomotor activity or conditioned taste aversion. J. Pharmacol. Exp. Ther. 269:137-144. 65. Kosten, T.A. and Nestler, E.J. (1994) Clozapine attenuates conditioned place preference to cocaine. Life Sci. 55:PL9-PL14. 66. Hope, B.T., Kelz, M.B., Duman, R.S., and Nestler, E.J. (1994) Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics. J. Neurosci. 14:4318-4328. 67. Self, D.W., Terwilliger, R.Z., Nestler, E.J., and Stein, L. (1994) Inactivation of Gi and Go proteins in nucleus accumbens reduces both cocaine and heroin reinforcement. J. Neurosci. 14:6239-6247. 68. Widnell, K.L., Russell, D., and Nestler, E.J. (1994) Regulation of cAMP response element binding protein in the locus coeruleus in vivo and in a locus coeruleus-like (CATH.a) cell line in vitro. Proc. Natl. Acad. Sci. USA 91:10947-10951. 69. Terwilliger, R.A., Ortiz, J., Guitart, X., and Nestler, E.J. (1994) Chronic morphine administration increases β-adrenergic receptor kinase (βARK) levels in the rat locus coeruleus. J Neurochem. 63:1983-1986. 70. Hope, B.T., Nye, H.E., Kelz, M.B., Self, D.W., Iadarola, M.J., Nakabeppu, Y., Duman, R.S., and Nestler, E.J. (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235-1244. 71. Miserendino, M.J.D. and Nestler, E.J. (1995) Behavioral sensitization to cocaine: Modulation by the cyclic AMP system in the nucleus accumbens. Brain Res. 674:299-306. 72. Ortiz, J., Harris, H.W., Guitart, X., Terwilliger, R.Z., Haycock, J.W., and Nestler, E.J. (1995) Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain. Regional distribution and regulation by chronic morphine. J. Neurosci. 15:1285-1297. 73. Fitzgerald, L.W., Deutch, A.Y., Gasic G., Heinemann, S.F., and Nestler, E.J. (1995) Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J. Neurosci. 15:2453-2461. 74. Rosin, D.L., Melia, K., Knorr, A.M., Nestler, E.J., Roth, R.H., and Duman, R.S. (1995) Chronic antidepressant administration alters the activity and phosphorylation state of tyrosine hydroxylase in dopainergic regions of rat brain. Neuropsychopharmacology 12:113-122. 75. Nestler, E.J., Terwilliger, R.Z., and Duman, R.S. (1995) Regulation of endogenous ADP-ribosylation by acute and chronic lithium in rat brain. J. Neurochem. 64:2319-2324. 76. Ortiz, J., DeCaprio, J., Guitart, X., Kosten, T.A., and Nestler, E.J. (1995) Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area. Neuroscience 67:383-397. 77. Fitzgerald, L.W., Charlton, M.E., Duman, R.S., and Nestler, E.J. (1995) Regulation of nitric oxide synthase by chronic ethanol ingestion. Synapse 21:93-95. 78. Berhow, M.T., Russell, D.S., Terwilliger, R.Z., Beitner-Johnson, D., Self, D.W., Lindsay, R.M., and Nestler, E.J. (1995) Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 68:969-979.

13

79. Chen, J.S., Nye, H.E., Kelz, M.B., Hiroi, N., Nakabeppu, Y., Hope, B.T., and Nestler, E.J. (1995) Regulation of ∆FosB and FosB-like proteins by electroconvulsive seizure (ECS) and cocaine treatments. Mol. Pharmacol. 48:880-889. 80. Ortiz, J., Fitzgerald, L.W., Charlton, M., Lane, S., Trevisan, L., Guitart, X., Shoemaker, W., Duman, R.S., and Nestler, E.J. (1995) Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 21:289-298. 81. Self, D.W., McClenahan, A.W., Beitner-Johnson, D., Terwilliger, R.Z., and Nestler, E.J. (1995) Biochemical adaptations in the mesolimbic dopamine system in response to heroin self-administration. Synapse 21:312-318. 82. Nye, H., Hope, B.T., Kelz, M., Iadarola, M., and Nestler, E.J. (1995) Pharmacological studies of the regulation by cocaine of chronic Fra (Fos-related antigen) induction in the striatum and nucleus accumbens. J. Pharmacol. Exp. Ther. 275:1671-1680. 83. Lee, M.J., Siajoh, K., Nestler, E.J., Duman, R.S., and Sumino, K. (1995) Regional differences in expression of osteonectin mRNA after administration of cadmium to rats. Arch. Toxicol. 69:590-595. 84. Fitzgerald, L.W., Ortiz, J., Hamedani, A.G., and Nestler, E.J. (1996) Regulation of glutamate receptor subunit expression by drugs of abuse and stress: Common adaptations among cross-sensitizing agents. J. Neurosci. 16:274-282. 85. Sklair-Tavron, L. and Nestler, E.J. (1996) Opposing effects of morphine and the neurotrophins, NT-3, NT-4, and BDNF, on locus coeruleus neurons in vitro. Brain Res. 702:117-125. 86. Widnell, K.L., Self, D.W., Lane, S.B., Russell, D.S., Vaidya, V., Miserendino, M.J.D., Rubin, C.S., Duman, R.S., and Nestler, E.J. (1996) Regulation of CREB expression: In vivo evidence for a functional role in morphine action in the nucleus accumbens. J. Pharmacol. Exp. Ther. 276:306-315. 87. Krystal, J.H., Compere, S., Nestler, E.J., and Rasmussen, K. (1996) Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiol. Behav. 59:863-866. 88. Harris, H.W. and Nestler, E.J. (1996) Immunohistochemical studies of mesolimbic dopamine neurons in Fischer 344 and Lewis rats. Brain Res. 706:1-12. 89. Self, D.W., Barnhart, W.J., Lehman, D.A., and Nestler, E.J. (1996) Opposite modulation of cocaine-seeking behavior by D1-like and D2-like dopamine receptor agonists. Science 271:1586-1589. 90. Widnell, K.L., Chen, J.-S., Iredale, P.A., Walker, W.H., Duman, R.S., Habener, J.F., and Nestler, E.J. (1996) Transcriptional regulation of CREB (cAMP Response Element-Binding Protein) expression in CATH.a cells. J. Neurochem. 66:1770-1773. 91. Nibuya, M., Nestler, E.J., and Duman, R.S. (1996) Chronic antidepressant administration increases the expression of CREB in rat hippocampus. J. Neurosci. 16:2365-2372. 92. Doucet, J.-P., Nakabeppu, Y., Bedard, P.J., Hope, B.T., Nestler, E.J., Jasmin, B., Chen, J.S., Iadarola, M.J., St-Jean, M., Wigle, N., Blanchet, P., Grondin, R., and Robertson, G.S. (1996) Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of striatal ∆FosB expression. Eur. J. Neurosci. 8:365-381. 93. Nye, H.E. and Nestler, E.J. (1996) Induction of chronic Fras (Fos-related antigens) in rat brain by chronic morphine administration. Mol. Pharmacol. 49:636-645. 94. Ortiz, J., Fitzgerald, L.W., Lane, S., Terwilliger, R., and Nestler, E.J. (1996) Biochemical effects of repeated stress in the mesolimbic dopamine system. Neuropsychopharmacology 14:393-402. 95. Berhow, M.T., Hiroi, N., and Nestler, E.J. (1996) Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. J. Neurosci. 16:4707-4715.

14

96. Alvaro, J.D., Tatro, J.B., Quillan, J.M., Fogliano, M., Eisenhard, M., Lerner, M.R., Nestler, E.J., and Duman, R.S. (1996) Cloning and characterization of the rat melanocortin-4 receptor and its regulation by morphine. Mol. Pharmacol. 50:583-591. 97. Sklair-Tavron, L., Shi, W.-X., Lane, S.B., Harris, H.W., Bunney, B.S., and Nestler, E.J. (1996) Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proc. Natl. Acad. Sci. USA 93:11202-11207. 98. Berhow, M.T., Hiroi, N., Kobierski, L., Hyman, S.E., and Nestler, E.J. (1996) Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system. J. Neurosci. 15:8019-8026. 99. Charlton, M.E., Sweetnam, P.M., Fitzgerald, L.W., Terwilliger, R.Z., Nestler, E.J., and Duman, R.S. (1996) Chronic ethanol administration regulates the expression of GABAA receptor α1 and α5 subunits in the ventral tegmental area and hippocampus. J. Neurochem. 68:121-127. 100. Kosten, T.A., DeCaprio, J.L., and Nestler, E.J. (1996) Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure. Psychopharmacology 128:304-312. 101. Iredale, P.A., Widnell, K.L., Terwilliger, R., Nestler, E.J., and Duman, R.S. (1996) Differential regulation of CRF1 receptor expression by stress and agonist treatments in brain and cultured cells. Mol. Pharmacol. 50:1103-1110. 102. Selley, D.E., Nestler, E.J., Breivogel, C.S., and Childers, S.R. (1997) Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: Decrease in G-protein activity after chronic morphine treatment. Brain Res. 746:10-18. 103. Chen, J., Kelz, M.B., Hope, B.T., Nakabeppu, Y., and Nestler, E.J. (1997) Chronic FRAs: Stable variants of ∆FosB induced in brain by chronic treatments. J. Neurosci. 17:4933-4941. 104. Carlezon, W.A., Jr., Boundy, V.A., Haile, C.N., Kalb, R.G., Neve, R., and Nestler, E.J. (1997) Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814. 105. Hiroi, N., Brown, J., Haile, C., Ye, H., Greenberg, M.E., and Nestler, E.J. (1997) FosB mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc. Natl. Acad. Sci. USA 94:10397-10402. 106. Lane-Ladd, S.B., Pineda, J., Boundy, V., Pfeuffer, T., Krupinski, J., Aghajanian, G.K., and Nestler, E.J. (1997) CREB in the locus coeruleus: Biochemical, physiological, and behavioral evidence for a role in opiate dependence. J. Neurosci. 17:7890-7901. 107. Gold, S.J., Ni, Y.G., Dohlman, H., and Nestler, E.J. (1997) Regulators of G protein signaling: Region-specific expression of nine subtypes in rat brain. J. Neurosci. 17:8024-8037. 108. Punch, L., Self, D.W., Nestler, E.J., and Taylor, J.R. (1997) Opposite modulation of opiate withdrawal behaviors upon microinfusion of a protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray. J. Neurosci. 17:8520-8527. 109. Kosten, T.A., Miserendino, M.J.D., Haile, C.N., DeCaprio, J.L., Jatlow, P.I., and Nestler, E.J. (1997) Lewis and Fischer inbred rat strain differences in acquisition and maintenance of intravenous cocaine self-administration. Brain Res. 778:418-429. 110. Self, D.W., Genova, L.M., Hope, B.T., Barnhart, W.J., Spencer, J.J., and Nestler, E.J. (1998) Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J. Neurosci. 18:1848-1859. 111. Brene, S., Messer, C.J., and Nestler, E.J. (1998) Expression of mRNAs encoding ionotropic glutamate receptors in rat brain: Regulation by haloperidol. Neuroscience 84:813-823. 112. Rocha, B.A., Scearce-Levie, K., Lucas, J., Hiroi, N., Castanon, N., Crabbe, J.C., Nestler, E.J., and Hen, R. (1998) Increased vulnerability to cocaine in mice lacking the serotonin 1B receptor. Nature 393:175-178.

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113. Chen, J.S., Kelz, M.B., Zeng, G.Q., Sakai, N., Steffen, C., Shockett, P.E., Picciotto, M., Duman, R.S., and Nestler, E.J. (1998) Transgenic animals with inducible, targeted gene expression in brain. Mol. Pharmacol. 54:495-503. 114. Hiroi, N., Marek, G.J., Brown, J., Ye, H., Saudou, F., Vaidya, V.A., Duman, R.S., Greenberg, M.E., and Nestler, E.J. (1998) Essential role of the fosB gene in molecular, cellular, and behavioral actions of electroconvulsive seizures. J. Neurosci. 18:6952-6962. 115. Fienberg, A.A., Hiroi, N., Mermelstein, P., Song, W.-J., Snyder G.L., Nishi, A., Cheramy, A., O’Callaghan, J.P., Miller, D., Cole, D.G., Corbett, R., Haile, C., Cooper, D.C., Onn, S., Grace, A., Ouimet, C.C., White, F.J., Hyman, S.E., Surmeier, D.J., Girault, J.A., Nestler, E.J., and Greengard, P. (1998) DARPP-32, regulator of the efficacy of dopaminergic neurotransmission. Science 281:838-842. 116. Boundy, V.A., Chen, J.S., and Nestler, E.J. (1998) Regulation of cAMP-dependent protein kinase subunit expression in CATH.a and SH-SY5Y cells. J. Pharmacol. Exp. Ther. 286:1058-1065. 117. Brodkin, E.S., Carlezon, W.A. Jr., Haile, C.N., Kosten, T.A., Heninger, G.R., and Nestler, E.J. (1998) Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: Initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice. Brain Res. 805:55-68. 118. Coven, E., Widnell, K.L., Chen, J.S., Walker, W.H., Habener, J.F., and Nestler, E.J. (1998) Cell-type specific regulation of CREB gene expression: Mutational analysis of CREB promoter activity. J. Neurochem. 71:1865-1874. 119. Boundy, V.A., Gold, S.J., Messer, C.J., Chen, J.S., Son, J.H., Joh, T.H, and Nestler, E.J. (1998) Regulation of tyrosine hydroxylase promoter activity by chronic morphine in TH9.0-LacZ transgenic mice. J. Neurosci. 18:9989-9995. 120. Numan, S., Lane-Ladd, S.B., Zhang, L., Lundgren, K.H., Russell, D.S., Seroogy, K.B., and Nestler, E.J. (1998) Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. J. Neurosci. 18:10700-10708. 121. Carlezon, W.A., Jr., Thome, J., Olson, V.G., Lane-Ladd, S.B., Brodkin, E.S., Hiroi, N., Duman, R.S., Neve, R.L., and Nestler, E.J. (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275. 122. Brodkin, E.S., Kosten, T.A., Haile, C.N., Heninger, G.R., Carlezon, W.A. Jr., Jatlow, P., Remmers, R.F., Wilder, R.L., and Nestler, E.J. (1998) Dark Agouti and Fischer 344 rats: Differential behavioral responses to morphine and biochemical differences in the ventral tegmental area. Neuroscience 88:1307-1315. 123. Carlezon, W.A., Jr., Rasmussen, K., and Nestler, E.J. (1999) The AMPA antagonist LY293558 blocks the development but not the expression of behavioral sensitization to morphine. Synapse 31:256-262. 124. Rahman, Z., Gold, S.J., Potenza, M.N., Ni, Y.G., Cowan, C.W., He, W., Wensel, T.G., and Nestler, E.J. (1999) Cloning and characterization of RGS9-2: A striatal-enriched alternatively spliced product of the RGS9 gene. J. Neurosci. 19:2016-2026. 125. Hiroi, N., Feinberg A., Haile, C., Greengard, P., and Nestler, E.J. (1999) Involvement of DARPP-32 in induction of ∆FosB variants and development of behavioral sensitization to cocaine. Eur. J. Neurosci. 11:1114-1118. 126. Ni, Y.G., Gold, S.J., Irdale, P.A., Terwiliger, R.Z., Duman, R.S., and Nestler, E.J. (1999) Region-specific regulation of RGS4 (regulator of G protein signaling protein type 4) in brain by stress and glucocorticoids. J. Neurosci. 19:3674-3680. 127. Horger, B.A., Iyasere, C.A., Berhow, M.T., Messer, C.J., Nestler, E.J., and Taylor, J.R. (1999) Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J. Neurosci. 19:4110-4122. 128. Atkins, J., Carlezon, W.A., Chlan, J., Nye, H.E., and Nestler, E.J. (1999) Region-specific induction of ∆FosB by repeated administration of typical versus atypical antipsychotic drugs. Synapse 33:118-128.

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129. Kelz, M.B., Chen, J.S., Carlezon, W.A., Whisler, K., Gilden, L., Beckmann, A.M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D.W., Tkatch, R., Baranauskas, G., Surmeier, D.J., Neve, R.L., Duman, R.S., Picciotto, M.R., and Nestler, E.J. (1999) Expression of the transcription factor ∆FosB in the brain controls sensitivity to cocaine. Nature 401:272-276. 130. Wolf, D.H., Numan, S., Nestler, E.J., and Russell, D.S. (1999) Regulation of phospholipase Cγ in the mesolimbic dopamine system by chronic morphine administration. J. Neurochem. 73:1520-1528. 131. Eisch, A.J., Hinrich-Lammers, M.M. Mouradian, and Nestler, E.J. (1999) In vivo regulation of glial-derived neurotrophic factor-inducible transcription factor (GIF) by kainic acid. Neuroscience 94:629-636. 132. Potenza, M.N. and Nestler, E.J. (1999) Effects of RGS proteins on the functional response of the µ opioid receptor in a melanophore-based assay. J. Pharmacol. Exp. Ther. 291:482-491. 133. Messer, C.J., Son, J.H, Joh, T.H., Beck, K.D., and Nestler, E.J. (1999) Regulation of tyrosine hydroxylase gene transcription in ventral midbrain by glial cell line-derived neurotrophic factor. Synapse 34:241-243. 134. Jolas, T., Nestler, E.J., and Aghajanian, G.K. (2000) Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: Association with an upregulation of the cyclic AMP pathway. Neuroscience 95:433-443. 135. Carlezon, W.A. Jr., Haile, C.N., Neve, R., and Nestler, E.J. (2000) Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus (HSV) vector expressing GluR1. J. Neurosci. 20:RC62, 1-5. 136. Messer, C.J., Eisch, A., Carlezon, W.A. Jr., Whisler, K., Shen, L., Westphal, H., Collins, F., and Nestler, E.J. (2000) Role of GDNF in biochemical and behavioral adaptations to drugs of abuse. Neuron 26:247-257. 137. Brene, S., Messer, C., Okado, H., Hartley, M., Heinemann, S.F., and Nestler, E.J. (2000) Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer element. Eur. J. Neurosci. 12:1525-1533. 138. Eisch, A.J., Barrot, M., Schad, C.A., Self, D.W., and Nestler, E.J. (2000) Opiates inhibit neurogenesis in the adult rat hippocampus. Proc. Natl. Acad. Sci. USA 97:7579-7584. 139. Nankova, B.B., Rivkin, M., Kelz, M., Nestler, E.J., and Sabban, E.L. (2000) Fra2: Potential modulator of the transcriptional activation in rat adrenal medulla evoked by repeated immobilization stress. J. Neurosci. 20:5647-5653. 140. Carlezon, W.A., Kosten, T.A., and Nestler, E.J. (2000) Behavioral interactions caused by combined administration of morphine and MK-801. Psychopharmacology 151:261-272. 141. Kelz, M.B., Kuszak, J.R., Yang, Y.Q., Ma, W.C., Steffen, C., Al-Ghoul, K., Zhang, Y.-J., Chen, J.S., Nestler, E.J., and Spector, A. (2000) ∆FosB induced cataract. Invest. Ophthalmol. Vis. Sci. 41:3523-3538. 142. Monteggia, L.M., Eisch, A.J., Tang, M.D., Kaczmarek, L.K., and Nestler, E.J. (2000) Cloning and characterization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Mol. Brain Res. 81:129-139. 143. Sabatakos, G., Sims, N.A., Chen, J., Aoki, K., Kelz, M.B., Amling, M., Bouali, Y., Mukhopadhyay, K., Ford, K., Nestler, E.J., and Baron, R. (2000) The transcription factor ∆FosB promotes bone formation and inhibits adipogenesis. Nat. Med. 6:985-990. 144. Chen, A.C.-H., Eisch, A.J., Sakai, N., Takahashi, M., Nestler, E.J., and Duman, E.J. (2000) Regulation of GFRα-1 and GFRα-2 mRNAs in rat brain by electroconvulsive seizure. Synapse 39:42-50. 145. Chen, J.S., Zhang, Y.J., Kelz, M.B., Steffen, C., Ang, E.S., Zeng, L., and Nestler, E.J. (2000) Induction of cyclin-dependent kinase 5 in hippocampus by chronic electroconvulsive seizures: Role of ∆FosB. J. Neurosci. 20:8965-8971.

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146. Malberg, J.E., Eisch, A.J., Nestler, E.J., and Duman, R.S. (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20:9104-9110. 147. Nestler, E.J. and Landsman, D. (2001) Learning about addiction from the human draft genome. Nature 409:834-835. 148. Bibb, J.A., Chen, J.S., Taylor, J.R., Svenningsson, P., Nishi, A., Snyder, G.L., Yan, Z., Sagawa, Z.K., Ouimet, C.C., Nairn, A.C., Nestler, E.J., and Greengard, P. (2001) Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410:376-380. 149. Josselyn, S.A., Shi, C.J., Carlezon, W.A. Jr., Neve, R.L., Nestler, E.J., and Davis, M. (2001) Long-term memory is facilitated by CREB overexpression in the amygdala. J. Neurosci. 21:2404-2412. 150. Akbarian, S., Bates, B., Lui, R.-J., Skirboll, S.L., Pejchal, T., Sun, L.D., Fan, G.-P., Kucera, J., Wilson, M.A., Kosofsky, B.E., Taylor, J.R., Bothwell, M., Nestler, E.J., Aghajanian, G.K., and Jaenisch, R. (2001) Neurotrophin-3 is essential for noradrenergic neuron function and opiate withdrawal. Mol. Psychiatry 6:593-604. 151. Haile, C.N., Hiroi, N., Nestler, E.J., and Kosten, T.A. (2001) Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats. Synapse 41:179-190. 152. Pliakas, A.M., Carlson, R.R., Neve, R.L., Konradi, C., Nestler, E.J., and Carlezon, W.A. Jr. (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated CREB expression in the nucleus accumbens. J. Neurosci. 21:7397-7403. 153. Ang, E., Chen, J.S., Zagouras, P., Magna, H., Holland, J., Schaeffer, E., and Nestler, E.J. (2001) Induction of NFκB in nucleus accumbens by chronic cocaine administration. J. Neurochem. 79:221-224. 154. Tekumalla, P.K., Calon, F., Rahman, Z., Birdi, S., Rajput, A.H., Hornykiewicz, O., Di Paolo, T., Bedard, P.J., and Nestler, E.J. (2001) Elevated levels of ∆FosB and RGS9 in striatum in Parkinson’s disease. Biol. Psychiatry 50:813-816. 155. Bräuer, A.U., Savaskan, N.E., Kole, M.H.P., Plaschke, M., Monteggia, L.M., Nestler, E.J., Simbürger, E., Deisz, R.A., Ninnemann, O., and Nitsch, R. (2001) Molecular and functional analysis of hyperpolarization-activated channels in the hippocampus after entorhinal cortex lesion. FASEB J. 15:2689-2701. 156. Hwang, C.K., D’Souza, U.M., Eisch, A.J., Yajima, S., Lammers, C.-H., Yang, Y., Lee, S.-H., Kim, Y.-M., Nestler, E.J., and Mouradian, M.M. (2001) Dopamine receptor regulating factor, DRRF: A zinc finger transcription factor. Proc. Natl. Acad. Sci. USA 98:7558-7563. 157. Mower, A.F., Liao, D.S., Nestler, E.J., Neve, R.L., and Ramoa, A.S. (2002) CREB function is essential for ocular dominance plasticity during monocular deprivation in the ferret. J. Neurosci. 22:2237-2245. 158. Shaw-Lutchman, T.Z., Barrot, M., Wallace, T., Gilden, L., Zachariou, V., Impey, S., Duman, R.S., Storm, D., and Nestler, E.J. (2002) Regional and cellular mapping of CRE-mediated transcription during naltrexone-precipitated morphine withdrawal. J. Neurosci. 22:3663-3672. 159. Nakagawa, S., Kim, J.-E., Lee, R., Malberg, J.E., Chen, J.S., Steffen, S., Zhang, Y.-J., Nestler, E.J., and Duman, R.S. (2002) cAMP-CREB signal transduction increases neurogenesis in adult mouse hippocampus. J. Neurosci. 22:3673-3682. 160. Akbarian, S., Rios, M., Liu, R.-J., Gold, S., Zeiler, S., Coppola, V., Tessarolla, L., Jones, K.R., Nestler, E.J., Aghajanian, G.K., and Jaenisch, J. (2002) Noradrenergic neuron dysfunction and attenuated opiate withdrawal in BDNF-deficient mice. J. Neurosci. 22:4153-4162. 161. Sakai, N., Thome, J., Chen, J.S., Kelz, M.B., Steffen, C., Nestler, E.J., and Duman, R.S. (2002) Inducible and brain region specific CREB transgenic mice. Mol. Pharmacol. 61:1453-1464. 162. Chen, J.S., Kelz, M.B., Zeng, G.Q., Steffen, C., Shockett, P.E., Terwilliger, G., Schatz, D.G., and Nestler, E.J. (2002) Inducible, reversible hair loss in transgenic mice. Transgenic Res. 11:241-247.

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163. Jentsch, J.D., Olausson, P., Nestler, E.J., and Taylor, J.R. (2002) Stimulation of protein kinase A activity in the rat amygdala enhances reward-related learning. Biol. Psychiatry 52:111-118. 164. Barrot, M., Olivier, J.D.A., Perrotti, L.I., Impey, S., Storm, D.R., Neve, R.L., Zachariou, V., and Nestler, E.J. (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA 99:11435-11440. 165. Sims, N.A., Sabatakos, G., Chen, J.S., Kelz, M.B., Nestler, E.J., and Baron, R. (2002) Regulating ∆FosB expression in adult tet-off-∆FosB transgenic mice alters bone formation and bone mass. Bone 30:32-39. 166. Werme, M., Messer, C., Olson, L., Gilden, L., Thorén, P., Nestler, E.J., and Brené, S. (2002) ∆FosB regulates wheel running. J. Neurosci. 22:8133-8138. 167. Gold, S.J., Heifets, B.D., Pudiak, C.M., and Nestler, E.J. (2002) Regulation of RGS mRNA expression by chronic electroconvulsive seizures in rat brain. J. Neurochem. 82:828-838. 168. Chao, J.R., Ni, Y.G., Bolanos, C.A., Chen, J.S., Rahman, Z., DiLeone, R.J., Olson, V.G., and Nestler, E.J. (2002) Characterization of the mouse adenylyl cyclase type VIII gene promoter: Regulation by cAMP and CREB. Eur. J. Neurosci. 16:1284-1294. 169. Newton, S.S., Thome, J., Wallace, T., Shirayama, Y., Dow, A., Schlesinger, L., Duman, C.H., Sakai, N., Chen, J.S., Neve, R., Nestler, E.J., and Duman, R.S. (2002) Inhibition of CREB or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J. Neurosci. 22:10883-10890. 170. Shaw-Lutchman, S.Z., Impey, S., Storm, D., and Nestler, E.J. (2003) Regulation of CRE-mediated transcription in mouse brain by amphetamine. Synapse 48:10-17. 171. Colby, C.R., Whisler, K., Steffen, C., Nestler, E.J., and Self, D.W. (2003) ∆FosB enhances incentive for cocaine. J. Neurosci. 23:2488-2493. 172. Peakman, M.C., Colby, C., Perrotti, L.I., Tekumalla, P., Carle, T., Ulery, P., Chao, J., Duman, C., Steffen, C., Monteggia, L., Allen, M.R., Stock, J.L., Duman, R.S., McNeish, J.D., Barrot, M., Self, D.W., Nestler, E.J., and Schaeffer, E. (2003) Inducible, brain region specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res. 970:73-86. 173. Gold, S.J., Han, M.-H., Herman, A.E., Ni, Y.G., Pudiak, Aghajanian, G.K., Liu, R.-J., C.M., Potts, B.W., Mumby, S.M., and Nestler, E.J. (2003) Regulation of RGS proteins in the locus coeruleus by chronic morphine. Eur. J. Neurosci. 17:971-980. 174. Georgescu, D., Zachariou, V., Barrot, M., Mieda, M., Willie, J.T., Eisch, A.J., Yanagisawa, M., Nestler, E.J., and DiLeone, R.J. (2003) Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J. Neurosci. 23:3106-3111. 175. Haberstock-Debic, H., Wein, M., Barrot, M., Colago, E.E.O., Neve, R.L., Pickel, V.M., Nestler, E.J., von Zastrow M., and Svingos, A.L. (2003) Morphine regulates opioid receptor membrane trafficking selectively in dendrites of nucleus accumbens neurons. J. Neurosci. 23:4324-4332. 176. Norrholm, S.D., Bibb, J.A., Nestler, E.J., Ouimet, C.C., Taylor, J.R., and Greengard, P. (2003) Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of the neuronal kinase Cdk5. Neuroscience 116:19-22. 177. Rahman, Z., Schwarz, J., Zachariou, V., Gold, S.J., Wein, M., Choi, K.H., Kovoor, A., Chen, C.K., DiLeone, R.J., Schwarz, S.C., Selley, D.E., Sim-Selley, L.J., Barrot, M., Leudtke, R.R., Self, D., Neve, R.L., Lester, H.A., Simon, M.I., and Nestler, E.J. (2003) RGS9 modulates dopamine signaling in striatum. Neuron 38:941-952. 178. Bolaños, C.A., Perrotti, L.I., Edwards, S., Eisch, A.J., Barrot, M., Olson, V.G., Russell, D.S., Neve, R.L., and Nestler, E.J. (2003) Viral-mediated expression of phospholipase Cγ in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. J. Neurosci. 23:7569-7576.

19

179. McClung, C.A. and Nestler, E.J. (2003) Regulation of gene expression and cocaine reward by CREB and ∆FosB. Nat. Neurosci. 11:1208-1215. 180. Zachariou, V., Georgescu, D., Sanchez, N., Rahman, Z., DiLeone, R., Berton, O., Simon, M., Neve, R.L., Sim-Selley, L.J., Selley, D.E., Gold, S.J., and Nestler, E.J. (2003) Essential role for RGS9 in opiate action. Proc. Natl. Acad. Sci. USA 100:13656-13661. 181. Eisch, A.J., Bolanos, C.A., Wit, J.D., Simonak, R.D., Pudiak, C.M., Barrot, M., Verhaagen, J., and Nestler, E.J. (2003) BDNF in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol. Psychiatry 54:994-1005. 182. Bolaños, C.A., Barrot, M., Berton, O., Wallace-Black, D., and Nestler, E.J. (2003) Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol. Psychiatry 54:1317-1329. 183. Chen, J., Newton, S.S, Zeng, L., Adams, D.H., Dow, A.L., Madsen, T.M., Nestler, E.J., and Duman, R.S. (2003) Downregulation of the CCAAT-enhancer binding protein beta in DeltaFosB transgenic mice and by electroconvulsive seizures. Neuropharmacology 29:23-31. 184. Potenza, M.N., Brodkin, E.S., Luo, X.G., Remmers, EF, Nestler, E.J., and Gelernter, J. (2004) Genomic regions controlling corticosterone levels in rats. Biol. Psychiatry 55:634-641. 185. Powell, C.M., Schoch, S., Monteggia, L., Barrot, M., Matos, M.F., Feldmann, N., Sudhof, T.C., and Nestler, E.J. (2004) The presynaptic active zone protein RIM1α is critical for normal associative learning. Neuron 42:143-153. 186. Tsankova, N.M., Kumar, A., and Nestler, E.J. (2004) Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J. Neurosci. 24 5603-5610. 187. Monteggia, L.M., Barrot, M., Powell, C.M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R.W., and Nestler, E.J. (2004) Essential role of BDNF in adult hippocampal function. Proc. Natl. Acad. Sci. USA 101:10827-10832. 188. Perrotti, L.I., Hadeishi, Y., Ulery, P., Barrot, M., Monteggia, L., Duman, R.S., and Nestler, E.J. (2004) Induction of ∆FosB in reward-related brain regions after chronic stress. J. Neurosci. 24:10594-10602. 189. Georgescu, D., Sears, R.M., Hommel, J.D., Barrot, M., Bolanos, C.A., Marsh, D.J., Bednarek, M.A., Bibb, J.A., Maratos-Flier, E., Nestler, E.J., and DiLeone, R.J. (2005) The hypothalamic neuropeptide MCH acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J. Neurosci. 25:2933-2940. 190. Hsu, R, Taylor, J.R., Newton, S.S., Alvaro, J.A., Haile, C., Han, G., Hruby, V.J., Nestler, E.J., and Duman, R.S. (2005) Blockade of melanocortin transmission inhibits cocaine reward. Eur. J. Neurosci. 21:2233-2242. 191. Barrot, M., Wallace-Black, D., Bolanos, C.A., Graham, D., Perrotti, L.I., Neve, R.L., Chambliss, H., Yin, J.C., and Nestler, E.J. (2005) Regulation of anxiety and initiation of sexual anxiety by CREB in the nucleus accumbens. Proc. Natl. Acad. Sci. USA 102:8357-8362. 192. Lucas, G., Compan, V., Charnay, Y., Neve, R.L., Nestler, E.J., Bockaert, J., Barrot, M., and Debonnel, G. (2005) Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Biol. Psychiatry 57:918-925. 193. Perrotti, L.I., Bolanos, C.A., Choi, K.-H., Russo, S.J., Edwards, S., Ulery, P.G., Wallace, D., Self, D.W., Nestler, E.J., and Barrot, M. (2005) ∆FosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur. J. Neurosci. 21:2817-2824. 194. Olson, V.G., Zabetian, C.P., Bolanos, C.A., Edwards, S., Barrot, M., Eisch, A.J., Hughes, T., Self, D.W., Neve, R.L., and Nestler, E.J. (2005) Regulation of drug reward by CREB: Evidence for two functionally distinct subregions of the ventral tegmental area. J. Neurosci. 25:5553-5562.

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195. Bolaños, C.A., Neve, R.L., and Nestler, E.J. (2005) Phospholipase Cγ in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity. Synapse 56:166-169. 196. McClung, C.A., Nestler, E.J., and Zachariou, V. (2005) Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J. Neurosci. 25:6005-6015. 197. McClung, C.A., Sidiropoulou, K., Vitaterna, M., Takahashi, J.S., White, F.J., Cooper, D.C., and Nestler, E.J. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc. Natl. Acad. Sci. USA 102:9377-9381. 198. Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N.M., Theobald, D.E.H., Truong, H.-T., Russo, S.J., LaPlant, Q., Sasaki, T.S., Whistler, K.N., Neve, R.L., Self, D.W., and Nestler, E.J. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48:303-314. 199. Zachariou, V., Bolanos, C.A., Selley, D.E., Theobald, D., Cassidy, M.P., Kelz, M.B., Shaw-Lutchmann, T., Berton, O., Sim-Selley, L.J., DiLeone, R.J., Kumar, A., and Nestler, E.J. (2006) ∆FosB: An essential role for ∆FosB in the nucleus accumbens in morphine action. Nat. Neurosci. 9:205-211. 200. Berton, O., McClung, C.A., DiLeone, R.J., Krishnan, V., Russo, S., Graham, D., Tsankova, N.M., Bolanos, C.A., Rios, M., Monteggia, L.M., Self, D.W., and Nestler, E.J. (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864-868. 201. Zachariou, V., Sgambato-Faure, V., Sasaki, T., Svenningsson, P., Fienberg, A.A., Nairn, A.C., Greengard, P., and Nestler, E.J. (2006) Phosphorylation of DARPP-32 at threonine-34 is required for cocaine action. Neuropsychopharmacology 31:555-562. 202. Kim, K.-S., Lee, K.-W., Lee, K.-W., Im, J.-Y., Yoo, J.Y., Kim, S.-W., Lee, J.-K., Nestler, E.J., and Han, P.-L. (2006) Adenylyl cyclase-5 is an essential mediator of morphine action. Proc. Natl. Acad. Sci. USA 103:3908-3913. 203. Dong, Y., Green, T., Saal, D., Marie, H., Neve, R., Nestler, E.J., and Malenka, R.C. (2006) CREB modulates excitability of nucleus accumbens neuron. Nat. Neurosci. 9:475-477. 204. Tsankova, N.M., Berton, O., Renthal, W., Kumar, A., Neve, R.L., and Nestler, E.J. (2006) Sustained hippocampal chromatin regulation in hippocampus in a mouse model of depression and antidepressant action. Nat. Neurosci. 9:519-525. 205. Han, M.-H., Bolaños, C.A., Green, T.A., Olson, V.G., Neve, R.L., Liu, R.-J., Aghajanian, G.K., and Nestler, E.J. (2006) Role of cAMP response element-binding protein (CREB) in the rat locus coeruleus: Regulation of neuronal activity and opiate withdrawal behaviors. J. Neurosci. 26:4624-4629. 206. Ulery, P.G., Rudenko, G., and Nestler, E.J. (2006) Regulation of ∆FosB stability by phosphorylation. J. Neurosci. 26:5131-5142. 207. Allen, P.B., Zachariou, V., Svenningsson, P., Lepore, A.C., Centonze, D., Costa, C., Rossi, S., Bender, G., Chen, G., Feng, J., Snyder, G.L., Bernardi, G., Nestler, E.J., Yan, Z., Calabresi, P., and Greengard, P. (2006) Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neuroscience 140:897-911. 208. Green, T.A., Alibhai, I.N., Hommel, J.D., DiLeone, R.J., Kumar, A., Theobald, D.E., Neve, R.L., and Nestler, E.J. (2006) Induction of ICER expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J. Neurosci. 26:8235-8242. 209. Olausson, P., Jentsch, J.D., Tronson, N., Neve, R., Nestler, E.J., and Taylor, J.R. (2006) ∆FosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J. Neurosci. 26:9196-9204. 210. Ulery, P.G. and Nestler, E.J. (2006) Regulation of ∆FosB transcriptional activity by ser27 phosphorylation. Eur. J. Neurosci. 25:224-230. 211. Olson, V.G. and Nestler, E.J. (2007) Topographical organization of GABAergic neurons within the ventral tegmental area of the rat. Synapse 61:87-95.

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212. Olson, V.G., Green, T.A., Neve, R.L., and Nestler, E.J. (2007) Regulation of morphine reward and feeding by CREB in the lateral hypothalamus. Synapse 61:110-113. 213. Monteggia, L.M., Luikart, B., Barrot, M., Theobald, D., Malkovska, I., Nef, S., Parada, L.F., and Nestler, E.J. (2007) BDNF conditional knockouts show gender differences in depression related behaviors. Biol. Psychiatry 61:187‑197. 214. Russo, S.J., Bolanos, C.A., Theobald, D.E., DeCarolis, N.A., Renthal, W.R., Kumar, A., Winstanley, C.A., Renthal, N.E., Wiley, M.D., Self, D.W., Russell, D.S., Neve, R.L., Eisch, A.J., and Nestler, E.J. (2007) The IRS2-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates. Nat. Neurosci. 10:93-99. 215. Taylor, J.R., Lynch, W.J., Sanchez, H., Olausson, P., Nestler, E.J., and Bibb, J.A. (2007) Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor activating and incentive motivational effects of cocaine. Proc. Natl. Acad. Sci. USA 104:4147-4152. 216. Alibhai, I.N. Green, T.A., Potashkin, J.A., and Nestler, E.J. (2007) Regulation of fosB and ∆fosB mRNA expression: in vivo and in vitro studies. Brain Res. 1143:22-33. 217. Roybal, K., Theobold, D., DiNieri, J.A., Graham, A., Russo, S., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M.H., Orsulak, P., Takahashi, J.S., Nestler, E.J., Carlezon, W.A. Jr., and McClung, C.A. (2007) Mania-like behavior induced by disruption of CLOCK. Proc. Natl. Acad. Sci. USA 104:6406-6411. 218. Carle, T.L., Ohnishi. Y.N., Ohnishi, Y.H., Alibhai, I.N., Wilkinson, M.B., Kumar, A., and Nestler, E.J. (2007) Absence of conserved C-terminal degron domain contributes to ∆FosB’s unique stability. Eur. J. Neurosci. 25:3009-3019. 219. Berton, O., Covington, H.E. III, Ebner, K., Tsankova, N.M., Carle, T.L., Ulery, P., Bhonsle, A., Barrot, M., Krishnan, V., Singewald, G.M., Singewald, N., Birnbaum, S., Neve, R.L., and Nestler, E.J. (2007) Induction of ΔFosB in the periaqueductal gray by stress promotes active coping responses. Neuron 55:289-300. 220. Jorissen, H., Ulery, P., Henry, L., Gourneni, S., Nestler, E.J., and Rudenko, G. (2007) Dimerization and DNA-binding properties of the transcription factor deltaFosB. Biochemistry 46:8360-8372. 221. Wolf, D.H., Nestler, E.J., and Russell, D.S. (2007) Regulation of neuronal PLCγ by chronic morphine. Brain Res. 1156:9-20. 222. Krishnan, V., Han, M.-H., Graham, D.L., Berton, O., Renthal, W., Russo, S.J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D.C., Ghose, S., Reister, R., Tannous, P., Green, T.A., Neve, R.L., Chakravarty, S., Kumar, A., Eisch, A.J., Self, D.W., Lee, F.S., Tamminga, C.A., Cooper, D.C., Gershenfeld, H.K., and Nestler, E.J. (2007) Susceptibility and resistance to social defeat are mediated through molecular adaptations in brain reward regions. Cell 131:391-404. 223. Winstanley, C.A., LaPlant, Q., Theobald, D.E.H., Green, T.A., Bachtell, R.K., Perrotti, L.I., DiLeone, R.J., Russo, S.J., Garth, W.J., Self, D.W., and Nestler, E.J. (2007) ∆FosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J. Neurosci. 27:10497-10507. 224. Renthal, W., Maze, I., Krishnan, V., Covington, H.E., Xiao, G.H., Kumar, A., Russo, S.J., Graham, A., Tsankova, N., Kerstetter, K.A., Kippin, T.E., Neve, R.L., Haggarty, S.J., McKinsey, T.A., Bassel-Duby, R., Olson, E.N., and Nestler, E.J. (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56:517‑529. 225. Perrotti, L.I., Weaver, R.R., Robison, B., Renthal, W., Maze, I., Yazdani, S., Elmore, R.G., Knapp, D.J., Selley, D.E., Martin, B.R., Sim-Selley, L., Bachtell, R.K., Self, D.W., and Nestler, E.J. (2008) Distinct patterns of ∆FosB induction in brain by drugs of abuse. Synapse 62:358-369. 226. Green, T.A., Alibhai, I.N., Unterberg, S., Neve, R.L., Ghose, S., Tamminga, C.A., and Nestler, E.J. (2008) Induction of activating transcription factors ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior. J. Neurosci. 28:2025-2032.

22

227. Huang, Y.H., Lin, Y., Brown, T.E., Han, M.H., Saal, D.B., Neve, R.L., Zukin, R.S., Sorg, B.A., Nestler, E.J., Malenka, R.C., and Dong, Y. (2008) CREB modulates the functional output of nucleus accumbens neurons: A critical role of NMDA receptor. J. Biol. Chem. 283:2751-2760. 228. Charlton, J.J., Allen, P.B., Psifogeorgou, K., Chakravarty, S., Gomes, I., Devi, L.A., Neve, R.L., Greengard, P., Nestler, E.J., and Zachariou, V. (2008) Multiple actions of spinophilin regulate mu opioid receptor function. Neuron 58:238-247. 229. Lutter, M., Krishnan, V., Russo, S.J., Jung, S., McClung, C.A., and Nestler, E.J. (2008) Orexin signaling mediates the antidepressant-like effect of calorie restriction. J. Neurosci. 28:3071-3075. 230. Steiner, M.A., Marsicano, G., Nestler, E.J., Holsboer, F., Lutz, B., and Wotjak, C.T. (2008) Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinology 33:54-67. 231. Zachariou, V., Liu, R.J., LaPlant, Q., Xiao, G.H., Renthal, W., Chan, G.C., Storm, D.R., Aghajanian, G.K., and Nestler, E.J. (2008) Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: Behavioral, electrophysiological, and molecular studies. Biol. Psychiatry 63:1013-1021. 232. Potenza, M.N., Brodkin, E.S., Yang, B.Z., Birnbaum, S.G., Nestler, E.J., and Gelernter, J. (2008) Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens. Neuropsychopharmacology 33:2735-2746. 233. Krishnan, V., Graham, A., Mazei-Robison, M.S., Lagace, D.C., Kim, K.-S., Birnbaum, S., Eisch, A.J., Han, P.-L., Storm, D.R., Zachariou, Z., and Nestler, E.J. (2008) Calcium sensitive adenylyl cyclases in depression and anxiety: Behavioral and biochemical consequences of isoform targeting. Biol. Psychiatry 64:336-343. 234. Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S.A., Anderson, J.G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J.K., Nestler, E.J., and Zigman, J.M. (2008) The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat. Neurosci. 11:752-753. 235. Renthal, W., Carle, T.L., Maze, I., Covington, H.E. III, Truong, H.-T., Alibhai, I., Kumar, A., Olson, E.N., and Nestler, E.J. (2008) ∆FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J. Neurosci. 28:7344-7349. 236. Teegarden, S.L., Nestler, E.J., and Bale, T.L. (2008) Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet. Biol. Psychiatry 64:941-950. 237. Pulipparacharuvil, S., Renthal, W., Hale, C.F., Taniguchi, M., Xiao, G.H., Kumar, A., Russo, S.J., Sikder, D., Dewey, C.M., Davis, M.M., Greengard, P., Nairn, A.C., Nestler, E.J., and Cowan, C.W. (2008) Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59:621-633. 238. Wallace, D.L., Vialou, V., Rios, L., Carle-Florence, T.L., Chakravarty, S., Kumar, A., Graham, D.L., Green, T.A., Kirk, A., Iniguez, S.D., Perrotti, L.I., Barrot, M., DiLeone, R.J., Nestler, E.J., and Bolaños, C.A. (2008) The influence of ∆FosB in the nucleus accumbens on natural reward-related behavior. J. Neurosci 28:10272-10277. 239. Iñiquez, S.D., Warren, B.L., Neve, R.L., Nestler, E.J., Russo, S.J., and Bolaños-Guzmån, C.A. (2008) Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine. Behav. Neurosci. 122:1172-1177. 240. Kim, K.-S., Lee, K.-W., Baek, I.-S., Lim, C.-M., Krishnan, V., Lee, J.-K., Nestler, E.J., and Han, P.-L. (2008) Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior. J. Neurochem. 107:105-115. 241. Krishnan, V., Mazei-Robison, M., Han, M.-H., Iñiquez, S.D., Ables, J.L., Vialou, V., Berton, O., Ghose, S., Covington, H.E. III, Wiley, M.D., Henderson, R.P., Neve, R.L., Eisch, A.J., Tamminga, C.A., Russo, S.J., Bolaños, C.A., and Nestler, E.J. (2008) Akt signaling within the ventral tegmental area regulates cellular and behavioral responses to emotional stimuli. Biol. Psychiatry 64:691-700.

23

242. Ulery-Reynolds, P.G., Castillo, M.A., Vialou, V., Russo, S.J., and Nestler, E.J. (2009) Phosphorylation of ∆FosB mediates its stability in vivo. Neuroscience 158:369-372. 243. Wallace, D.L., Han, M.-H., Graham, D.L., Green, T.A., Vialou, V., Iniguez, S.D., Cao, J.L., Chakravarty, S., Kumar, A., Krishnan, V., Neve, R.L., Cooper, D.C., Bolaños, C.A., Barrot, M., McClung, C.A., and Nestler, E.J. (2009) CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat. Neurosci. 12:200-209. 244. DiNieri, J.A., Nemeth, C., Parsegian, A., Carle, T., Gurevich, V.V., Gurevich, E., Neve, R.L., Nestler, E.J., and Carlezon, W.A. Jr. (2009) Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. J. Neurosci. 29:1855-1859. 245. Russo, S.J., Wilkinson, M.B., Mazei-Robison, M.S, Dietz, D.M., Maze, I., Krishnan, V., Renthal, W., Graham, A., Birnbaum, S.G., Green, T.A., Robison, B., Lesselyong, A., Perrotti, L.I., Bolaños, C.A., Kumar, A., Clark, M.S., Neumaier, J.F., Neve, R.L., Bhakar, A.L., Baker, P.A., and Nestler, E.J. (2009) Nuclear factor κB signaling regulates neuronal morphology and cocaine reward. J. Neurosci. 29:3529-3537. 246. Rogge, G.A., Jones, D.C., Green, T., Nestler, E.J., and Kuhar, M.J. (2009) Regulation of CART peptide expresson by CREB in the rat nucleus accumbens. Brain Res. 1251:42-52. 247. Winstanley, C.A., Bachtell, R.K., Theobald, D.E.H., Laali, S., Green, T.A., Kumar, A., Chakravarty, S., Self, D.W., and Nestler, E.J. (2009) Increased impulsivity during withdrawal from cocaine self-administration: Role for ∆FosB in the orbitofrontal cortex. Cerebral Cortex 19:435-444. 248. Freet, C.S., Steffen, C., Nestler, E.J., and Grigson, P.S. (2009) Overexpression of ∆FosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice. Behav. Neurosci. 123:397-407. 249. Renthal, W., Kumar, A., Xiao, G.H., Wilkinson, M., Covington, H.E. III, Maze, I., Sikder, D., Robison, A.J., LaPlant, Q., Dietz, D.M., Russo, S.J., Vialou, V., Chakravarty, S., Kodadek, T.J., Stack, A., Kabbaj, M., and Nestler, E.J. (2009) Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins. Neuron 62:335-348. 250. Graham, D.L., Krishnan, V., Larson, E.B., Graham, A., Edwrds, S., Bachtell, R.K., Simmons, D., Berton, O., Bolaños, C.A., DiLeone, R.J., Parada, L.F., Nestler, E.J., and Self, D.W. (2009) TrkB in the mesolimbic dopamine system: Region-specific effects on cocaine reward. Biol. Psychiatry 65:696-701. 251. LaPlant, Q., Chakravarty, S., Vialou, V., Mukherjee, S., Koo, J.-W., Kalahasti, G., Bradbury, K.R., Taylor, S.V., Maze, I., Kumar, A., Graham, A., Birnbaum, S.G., Krishnan, V., Truong, H.-T., Neve, R.L., Nestler, E.J., and Russo, S.J. (2009) Role of NFκB in ovarian hormone mediated stress hypersensitivity in female mice. Biol. Psychiatry 65:874-880. 252. Winstanley, C., Green, T.A., Theobald, D.E., Renthal, W., LaPlant, Q., DiLeone, R., Chakravarty, S., and Nestler, E.J. (2009) ∆FosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine. Pharmacol. Biochem. Behav. 93:278-284. 253. Wilkinson, M.B., Xiao, G.H., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T.J., and Nestler, E.J. (2009) Imipramine treatment and resiliency exhibit similar chromatin regulation in a key brain reward region. J. Neurosci. 29:7820-7832. 254. Hedges, V.L., Chakravarty, S., Nestler, E.J., and Meisel, R.L. (2009) ΔFosB overexpression in the nucleus accumbens enhances sexual reward in female Syrian hamsters. Genes Brain Behav. 8:442-449. 255. Watanabe, H., Henriksson, R., Ohnishi, Y.N., Ohnishi, Y.H., Harper, C., Sheedy, D., Garrick, T., Nyberg, F., Nestler, E.J., Bakalkin, G., and Yakovlva, T. (2009) FosB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics. Addiction Biol. 14:294-297. 256. Berton, O., Guigoni, C., Li, O., Bioulac, B.H., Aubert, I., Gross, C.E., DiLeone, R., Nestler, E.J., and Bezard, E. (2009) Striatal overexpression of ∆JunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease. Biol. Psychiatry 66:554-561.

24

257. Covington, H.E. III, Maze, I., LaPlant, Q.C., Vialou, V.F., Yoshinori, O.N., Berton, O., Fass, D.M., Renthal, W., Rush, A.J. III, Wu, E.Y., Ghose, S., Krishnan, V., Russo, S.J., Tamminga, C., Haggarty, S.J., and Nestler, E.J. (2009) Antidepressant actions of HDAC inhibitors. J. Neurosci. 29:11451-11460. 258. Wang, H., Westin, L., Nong, Y., Birnbaum, S., Bendor, J., Brismar, H., Nestler, E.J., Aperia, A., Flajolet, M., and Greengard, P. (2009) Norbin is an endogenous regulator of metabotropic glutamate receptor 5: Relevance to schizophrenia. Science 326:1554-1557. 259. Maze, I., Covington, H.E. III, Dietz, D.M., LaPlant, Q., Renthal, W., Russo, S.J., Mechanic, M., Mouzon, E., Neve, R.L., Haggarty, S.J., Ren, Y.H., Sampath, S.C., Hurd, Y.L., Greengard, P., Tarakovsky, A., Schaefer, A., and Nestler, E.J. (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327:213-216. 260. Green, T.A., Alibhai, I.N., Roybal, C.N., Winstanley, C.A., Theobald, D.E.H., Birnbaum, S.G., Graham, A.R., Unterberg, S., Graham, D.L., Vialou, V., Bass, C.E., Terwilliger, E.F., Bardo, M.T., and Nestler, E.J. (2010) Environmental enrichment produces a behavioral phenotype mediated by low CREB activity in the nucleus accumbens. Biol. Psychiatry 67:28-35. 261. Liu, Y., Aragona, B.J., Young, K.A., Dietz, D.M., Kabbaj, M., Mazei-Robison, M., Nestler, E.J., and Wang, Z.X. (2010) Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species. Proc. Natl. Acad. Sci. USA 107:1217-1222. 262. Koo, J.W., Russo, S.J., Ferguson, D., Nestler, E.J., and Duman, R.J. (2010) Nuclear factor-κB is a critical mediator of stress-impaired neurogeneis and depressive behavior. Proc. Natl. Acad. Sci. USA 107:2669-2674. 263. Lagace, D.C., Donovan, M.H., DeCarolis, N.A., Farnbauch, L.A., Malhotra, S., Berton, O., Nestler, E.J., Krishnan, V., and Eisch, A.J. (2010) Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance. Proc. Natl. Acad. Sci. USA 107:4436-4441. 264. Sun, H.S., Green, T.A., Theobald, D.E.H., Laali, S., Shrikhande, G., Birnbaum, S., Kumar, A., Chakravarty, S., Graham, D., Nestler, E.J., and Winstanley, C.A. (2010) The pharmacological stressor yohimbine increases impulsivity through activation of CREB in the orbitofrontal cortex. Biol. Psychiatry 67:649-656. 265. Han, M.-H., Renthal, W., Ring, R.H., Rahman, Z., Psifogeorgou, D., Howland, D., Birnbaum, S., Young, K., Neve, R., Nestler, E.J., and Zachariou, V. (2010) Brain region specific actions of RGS4 oppose morphine reward and dependence but promote analgesia. Biol. Psychiatry 67:761-769. 266. Vialou, V., Robison, A.J., LaPlant, Q.C., Covington, H.E. III, Dietz, D.M., Ohnishi, Y.N., Mouzon, E., Rush, A.J. III, Watts, E.L., Wallace, D.L., Iñiguez, S.D., Ohnishi, Y.H., Steiner, M.A., Warren, B., Krishnan, V., Neve, R.L., Ghose, S., Berton, O., Tamminga, C.A., and Nestler, E.J. (2010) ∆FosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat. Neurosci. 13:745-752. 267. Chuang, J.C., Krishnan, V., Yu, H.G., Mason, B., Cui, H.X., Wilkinson, M.B., Zigman, J.M., Elmquist, J.K., Nestler, E.J., and Lutter, M. (2010) A β3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress. Biol. Psychiatry 67:1075-1082. 268. Enwright JF III, Wald M, Paddock M, Hoffman E, Arey R, Edwards S, Spencer S, Nestler EJ, McClung CA (2010) DeltaFosB indirectly regulates Cck promoter activity. Brain Res. 1329:10-20. 268. Iñiguez, S., Vialou, V., Warren, B., Cao, J.-L., Alcantara, L., Davis, L., Manojlovic, Z., Neve, R., Russo, S., Han, M.H., Nestler, E.J., and Bolaños-Guzman, C. (2010) Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. J. Neurosci. 30:7652-7663. 269. Iñiguez, S.D., Warren, B.L, Neve, R.L., Russo, S.J., Nestler, E.J., and Bolaños, C.A. (2010) Viral-mediated expression of extracellular signal-regulate kinase-2 in the ventral tegmental area modulates behavioral responses to cocaine. Behav. Brain Res. 214:460-464. 270. Larson, E.B., Akkentli, F., Edwards, S., Graham, D.L., Simmons, D.L., Alibhai, I.N., Nestler, E.J., and Self, D.W. (2010) Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. J. Neurochem. 115:112-122.

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271. LaPlant, Q., Vialou, V., Covington, H.E., Dumitriu, D., Feng, J., Warren, B., Maze, I., Dietz, D.M., Watts, E.L., Iñiquez, S.D., Koo, J.-W., Mouzon, E., Renthal, W., Hollis, F., Wang, H., Noonan, M.A., Ren, Y.H., Eisch, A.J., Bolaños, C.A., Kabbaj, M., Xiao, G.H., Neve, R.L., Hurd, Y.L., Oosting, R.S., Fan, G.P., Morrison, J.H., and Nestler, E.J. (2010) Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat. Neurosci. 13:1137-1143. 272. Bateup, H.S., Santini, E., Shen, W.X., Birnbaum, S., Valjent, E., Surmeier, D.J., Fisone, G., Nestler, E.J., and Greengard, P. (2010) Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc. Natl. Acad. Sci. USA 107:14845-14850. 273. Cao, J.-L., Vialou, V.F., Lobo, M.K., Robison, A.J., Neve, R.L., Cooper, D.C., Nestler, E.J., Han, M.-H. (2010) Essential role of the cAMP-CREB pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. Proc. Natl. Acad. Sci. USA 107:17011-17016. 274. Lobo, M.K., Covington, H.E. III, Chaudhury, D., Friedman, A.K., Sun, H.S., Damez-Werno, D., Dietz, D., Zaman, S., Koo, J.W., Kennedy, P.J., Mouzon, E., Mogri, M., Neve, R.L., Deisseroth, K., Han, M.H., and Nestler, E.J. (2010) Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390. 275. Vialou, V., Maze, I., Renthal, W., LaPlant, Q.C., Watts, E.L., Mouzon, E., Ghose, S., Tamminga, C.A., and Nestler, E.J. (2010) Serum response factor promotes resilience to chronic social stress through the induction of ∆FosB. J. Neurosci. 30:14585-14592. 276. Berger, A.K., Green, T., Siegel, S.J., Nestler, E.J., and Hammer, R.P. (2010) CREB phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D2-like receptor agonist treatment in rats. Biol. Psychiatry 69:288-294. 277. Cao, J.-L., Covington, H.E. III, Friedman, A.K., Wilkinson, M.B., Walsh, J.J., Cooper, D.C., Nestler, E.J., and Han, M.-H. (2010) Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. J. Neurosci. 30:16453-16458. 278. Covington, H.E. III, Lobo, M.K., Maze, I., Vialou, V., Hyman, J.M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C.A., Neve, R.L., Deisseroth, K., and Nestler, E.J. (2010) Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J. Neurosci. 30:16082-16090. 279. Pitchers, K.K., Frohmader, K.S., Vialou, V., Mouzon, E., Nestler, E.J., Lehman, M.N., and Coolen, L.M. (2010) ∆FosB in the nucleus accumbens is critical for reinforcing effects of sexual reward. Genes Brain Behav. 9:831-840. 280. Maze, I., Feng, J., Wilkinson, M.B., Sun, H.S., Shen, L., and Nestler, E.J. (2011) Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc. Natl. Acad. Sci. USA 108:3035-3040. 281. Covington, H.E. III, Vialou, V.F., LaPlant, Q.C., Ohnishi, Y.N., and Nestler, E.J. (2011) Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition. Neurosci. Lett. 493:122-126. 282. Choi, K.H., Edwards, S., Graham, D.L., Larson, E.B., Whisler, K.N., Simmons, D., Friedman, A.K., Walsh, J.J., Rahman, Z., Monteggia, L.M., Eisch, A.J., Neve, R.L., Nestler, E.J., Han, M.-H., and Self, D.W. (2011) Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. J. Neurosci. 31:7927-7937. 283. Scott, M.M., Marcus, J.N., Pettersen, A., Birnbaum, S.G., Mochizuki, T., Scammell, T.E., Nestler, E.J., Elmquist, J.K., and Lutter, M. (2011) Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav. Brain Res. 222:289-294. 284. Brown, B.E., Lee, B.R., Mu, P., Ferguson, D., Dietz, D., Ohnishi, Y.N., Lin, Y., Suska, A., Ishikawa, M., Huang, Y.H., Shen, H.W., Kalivas, P.W., Sorg, B.A., Zukin, R.S., Nestler, E.J., Dong, Y., and Schlüter, O.M. (2011) A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J. Neurosci. 31:8163-8174.

26

285. Wilkinson, M.B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M.K., Kennedy, P., Dietz, D., Covington, H. III, Russo, S., Neve, R., Ghose, S., Tamminga, C., and Nestler, E.J. (2011) A novel role of the WNT-Dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression. J. Neurosci. 31:9084-9092. 286. Vialou, V., Cui, H., Perello, M., Mahgoub, M., Yu, H.G., Rush, A.J., Pranav, H., Jung, S., Yanagisawa, M., Zigman, J.M., Elmquist, J.K., Nestler, E.J., and Lutter, M. (2011) A role for ∆FosB in calorie restriction-induced metabolic changes. Biol. Psychiatry 70:204-207. 287. Covington, H.E. III, Maze, I., Sun, H.S., Wu, E.Y., Dietz, D., Lobo, M.K., Ghose, S., Neve, R., Tamminga, C.A., and Nestler, E.J. (2011) A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 71:656-670. 288. Dietz, D.M., LaPlant, Q., Watts, E.L., Hodes, G.E., Russo, S.J., Feng, J., Oosting, R.S., and Nestler, E.J. (2011) Paternal transmission of stress-induced pathologies. Biol. Psychiatry 70:408-414. 289. Knoll, A.T., Muschamp, J.W., Sillivan, S.E., Ferguson, D., Dietz, D.M., Meloni, E.G., Carroll, F.I., Nestler, E.J., Konradi, C., and Carlezon, W.A. Jr. (2011) Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol. Psychiatry 70:425-433. 290. Ohnishi, Y.N., Ohnishi, Y.H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Sakumi, K., Nestler, E.J., and Nakabeppu, Y. (2011) FosB Is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB. Biol. Psychiatry 70:487-495. 291. Sim-Selley, L.J., Cassidy, M.P., Sparta, A., Zachariou, V., Nestler, E.J., and Selley, D.E. (2011) Effect of ∆FosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens. Neuropharmacology 61:1470-1476. 292. Larson, E.B., Graham, D.L., Arzaga, R.R., Buzin, N., Webb, J., Green, T.A., Bass, C.E., Neve, R.L., Terwilliger, E.F., Nestler, E.J., and Self, D.W. (2011) Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. J. Neurosci. 31:16447-16457. 293. Mazei-Robison, M.S., Koo, J.W., Friedman, A., Lansink, C.S., Robison, A.J., Vinish, M., Krishnan, V., Kim, S., Siuta, M.A., Galli, M.A., Niswender, K.D., Appasani, R., Horvath, M.C., Neve, R.L., Worley, P.F., Snyder, S.H., Hurd, Y.L., Cheer, J.F., Han, M.H., Russo, S.J., and Nestler, E.J. (2011) Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 72:977-990. 294. Muschamp, J.W., Nemeth, C.L., Robison, A.J., Nestler, E.J., and Carlezon, W.A., Jr. (2012) ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid agonist U50488. Biol. Psychiatry 71:44-50. 295. Dumitriu, D., LaPlant, Q., Grossman, Y.S., Dias, C., Janssen, W.G., Russo, S.J., Morrison, J.H., and Nestler, E.J. (2012) Subregion, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. J. Neurosci. 16:6957-6966. 296. Tronson, N.C., Wiseman, S.L., Neve, R.L., Nestler, E.J., Olausson, P., and Taylor, J.R. (2012) Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory. Learning Memory 19178-181. 297. Vialou, V., Feng, J., Robison, A.J., Ku, S.M., Ferguson, D., Scobie, K.N., Mazei-Robison, M.A., Mouzon, E., and Nestler, E.J. (2012) Serum response factor and cAMP response element binding protein are both required for cocaine induction of ∆FosB. J. Neurosci. 32:7577-7584. 298. Wang, Y., Cesena, T., Ohnishi, Y., Burger-Caplan, R., Vivian, L., Kirchhoff, P., Scott, L., Larsen, M., Nestler, E.J., and Rudenko, G. (2012) Small molecule screening identifies regulators of the transcription factor DeltaFosB. ACS Chem. Neurosci. 3:546-556.

27

299. Cunningham, J.T., Nedungadi, T.P., Walch, J.D., Nestler, E.J., and Gottlieb, H.B. (2012) ∆FosB in the supraoptic nucleus contributes to hyponatremia in rats with cirrhosis. Am. J. Physiol. Regul. Integr. Comp. Physiol 303:R177-R185. 300. Cunningham, J.T., Knight, W.D., Chakravarty, S. Mifflin, S.W., and Nestler, E.J. (2012) An essential role for ∆FosB in the median preoptic nucleus in the sustained hypertensive effects of chronic intermittent hypoxia. Hypertension 60:179-187. 301. Damez-Werno, D., LaPlant, Q., Dietz, D.M., Sun, S.H., Scobie, K.N., Walker, I., Koo, J.W., Mouzon, E., Russo, S.J., and Nestler, E.J. (2012) Drug experience epigenetically primes fosB gene inducibility in rat nucleus accumbens and caudate putamen. J. Neurosci. 32:10267-10272. 302. Dietz, D.M., Sun, H.S., Lobo, M.K., Cahill, M.E., Chadwick, B., Gao, V., Koo, J.W., Mazei-Robison, M.S., Dias, C., Maze, I., Damez-Werno, D., Dietz, K.C., Scobie, K.N., Ferguson, D., Christofell, D., Ohnishi, Y., Hodes, G.E., Zheng, Y., Neve, R.L., Hahn, K.M., Russo, S.J., and Nestler, E.J. (2012) Rac1 is essential in cocaine-induced structure plasticity of nucleus accumbens neurons. Nat. Neurosci. 15:891-896. 303. Rowe, G.C., Vialou, V., Sato, K., Saito, H., Yin, M., Green, T.A., Lotinun, S., Kveiborg, M., Horne, W.C., Nestler, E.J., and Baron, R. (2012) Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus. J. Bone Miner. Res. 27:1649-1658. 304. Kurita, M., Holloway, T., Garcia-Bea, A., Kozlenkov, A., Friedman, A.K., Moreno, J.L., Heshmati, M., Golden, S.A., Kennedy, P.J., Takahashi, N., Dietz, D.M., Mocci, G., Gabilondo, A.M., Hanks, J., Umali, A., Callado, L.F., Gallitano, A.L., Neve, R.L., Shen, L., Buxbaum, J.D., Han, M.H., Nestler, E.J., Meana, J.J., Russo, S.J., and Gonzalez-Maeso, J. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGluR2 promoter activity. Nat. Neurosci. 15:1245-1254. 305. Koo, J.W., Mazei-Robison, M.S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H.S., Scobie, K.N., Damez-Werno, D., Crumiller, M., Ohnishi, Y.N., Ohnishi, Y.H., Mouzon, E., Dietz, D.M., Lobo, M.K., Neve, R.L., Russo, S.J., Han, M.H., and Nestler, E.J. (2012) BDNF is a negative modulator of morphine action. Science 338:124-128. 306. Sun, H.S., Maze, I., Dietz, D.M., Scobie, K.N., Kennedy, P.J., Damez-Werno, D., Neve, R.L., Zachariou, V., Shen, L., and Nestler, E.J. (2012) Morphine epigenetically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens. J. Neurosci. 32:17454-17464. 307. Tomasiewicz, H.C., Jacobs, M.M., Wilkinson, M.B., Wilson, S.P., Nestler, E.J., and Hurd, Y.L. (2012) Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. Biol. Psychiatry 72:803-810. 308. Liu, J., Dietz, K., Deloyht, J.M., Pedre, X., Kelkar, D., Kaur, J., Vialou, V., Lobo, M.K., Dietz, D.M., Nestler, E.J., Dupree, J., and Casaccia, P. (2012) Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat. Neurosci. 15:1621-1623. 309. Warren, B.L., Vialou, V.F., Iñiguez, S.D., Alcantara, L.F., Wright, K.N., Feng, J., Kennedy, P.J., LaPlant, Q., Shen, L., Nestler, E.J. and Bolaños-Guzman (2013) Neurobiological sequelae of witnessing stressful events in adult mice. Biol. Psychiatry 73:7-14. 310. Chaudhury, D., Walsh, J.J. Friedman, A.K., Juarez, B., Ku, S.M., Koo, J.W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D.J., Nextow, A.R., Ekstrand, M., Domingos, A., Mazie-Robison, M., Mouzon, E., Lobo, M.K., Neve, R.L., Friedman, J.M., Russo, S.J., Deisseroth, K., Nestler, E.J., and Han, M.-H. (2013) Rapid regulation of depression-related behaviors by control of midbrain dopamine neurons. Nature 493:532-536. 311. Suri, D., Veenit, V., Sarkar, A., Thiagrarjan, D., Kumar, A., Nestler, E.J., Galande, S., and Vaidya, V.A. (2013) Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, Bdnf expression and cognition. Biol. Psychiatry 73:658-666.

28

312. Xiao, G.H., Wang, X.L., LaPlant, Q., Nestler, E.J., and Xie, Y. (2013) Detection of epigenetic changes using ANOVA with spatially varying coefficients. Stat. Appl. Genet. Mol. Biol. 13:1-17. 313. Grueter, B.A., Robison, A.J., Neve, R.L., Nestler, E.J., and Malenka, R.C. (2013) ∆FosB differentially modulates nucleus accumbens direct and indirect pathway function. Proc. Natl. Acad. Sci. USA 110:1923-1928. 314. Pitchers, K.K., Vialou, V., Nestler, E.J., Lehman, M.N., and Coolen, L.M. (2013) Natural and drug rewards act on common neural plasticity mechanisms with ∆FosB as a key mediator. J. Neurosci. 33:3434-3442. 315. Robison, A.J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S.M., Koob, G., Turecki, G., Neve, R., Thomas, M., and Nestler, E.J. (2013) Behavioral and structural responses to chronic cocaine require a feed-forward loop involving ∆FosB and CaMKII in the nucleus accumbens shell. J. Neurosci. 33:4295-4307. 316. Kennedy, P.J., Robison, A.J., Maze, I., Feng, J., Badimon, A., Bassel-Duby, R., Olson, E.N., and Nestler, E.J. (2013) Class I HDAC inhibition blocks cocaine-induced plasticity through targeted changes in histone methylation. Nat. Neurosci. 16:434-440. 317. Stratinaki, M., Varidaki, A., Mitsi, V., Ghose, S., Magida, J., Dias, C., Russo, S.J., Vialou, V., Caldarone, B.J., Tamminga, C.A., Nestler, E.J., and Zachariou, V. (2013) Regulator of G protein signaling 4 is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proc. Natl. Acad. Sci. USA 110:8254-8259. 318. Thanos, P.K., Robison, L., Nestler, E.J., Kim, R., Michaelides, M., Lobo, M.K., and Volkow, N.D. (2013) Mapping brain metabolic connectivity in awake rats with µPET and optogenetic stimulation. J. Neurosci. 33:6343-6349. 319. Kurita, M., Moreno, J.L., Holloway, T., Kozlenkov, A., Mocci, G., Garcia-Bea, A., Hanks, J.B., Neve, R., Nestler, E.J., Russo, S.J., and Gonzalez-Maeso, J. (2013) Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Mol. Pharmacol. 83:1166-1175. 320. Shen, L., Shao, N.Y., Liu, X.C., Maze, I., Feng, J., and Nestler, E.J. (2013) diffReps: Detecting differential chromatin modification sites from ChIP-seq data with biological replicates. PLoS One 8:e65598. 321. Been, L.E., Hedges, V.L., Vialou, V., Nestler, E.J., and Meisel, R.L. (2013) ∆JunD overexpression in the nucleus accumbens prevents sexual reward in female Syrian hamsters. Genes Brain Behav. 12:666-672. 322. Lee, B.R., Ma, Y.-Y., Huang, Y.H., Wang, X.S., Otaka, M., Ishikawa, M., Neumann, P.A., Graziane, N.M., Brown, T.E., Suska, A., Guo, C.Y., Lobo, M.K., Sesack, S.R., Wolf, M.E., Nestler, E.J., Shaham, Y., Schlüter, O.M., and Dong, Y. (2013) Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat. Neurosci. 16:1644-1651. 323. Ferguson, D., Koo, J.W., Feng, J., Heller, E., Rabkin, J., Heshmati, M., Renthal, W., Neve, R., Liu, X., Shao, N., Sartorelli, V., Shen, L., and Nestler, E.J. (2013) Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. J. Neurosci. 33:16088-16098. 324. Lobo, M.K., Zaman, S., Damez-Werno, D.M., Koo, J.W., Bagot, R.C., DiNieri, J.A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., Ribeiro, E., Rabkin, J., Mouzon, E., Cachope, R., Cheer, J.F., Han, M.H., Dietz, D.M., Self, D.W., Hurd, Y.L., Vialou, V., and Nestler, E.J. (2013) ∆FosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J. Neurosci. 33:18381-18395. 325. Manitt, C., Eng, C., Polinko, M., Ryan, R., Torres-Berrîo, A., Lopez, J., Yogendran, S., Daubaras, M., Grant, A., Schmidt, E.R., Tronche, F., Krimpenfort, P., Cooper, H., Pasterkamp, J., Kolb, B., Turecki, G., Wong, T.P., Nestler, E.J., Giros, B., and Flores, C. (2013) dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Trans. Psychiatry 3:e338. 326. Iñiguez, S., Alcantara, L., Warren, B., Riggs, L., Parise, E., Vialou, V., Wright, K., Dayrit, G., Nieto, S., Wilkinson, M., Lobo, M.K., Neve, R., Nestler, E.J., and Bolaños-Guzman, C. (2014) Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood. J. Neurosci. 34:1007-1021. 327.Walsh, J.J., Friedman, A.K., Sun, H.S., Heller, E.A., Ku, S.M., Juarez, B., Burnham, V.L., Mazei-Robison,

29

M.S., Ferguson, D., Golden, S.A., Koo, J.W., Chaudhury, D., Christoffel, D.J., Pomeranz, L., Friedman, J.M., Russo, S.J., Nestler, E.J., and Han, M.H. (2014) Stress gates neural activation of BDNF in the mesolimbic reward pathway. Nat. Neurosci. 17:27-29. 328. Scobie, K.N., Damez-Werno, D., Sun, H., Shao, N., Gancarz, A., Panganiban, C.H., Dias, C., Koo, J., Caiafa, P., Kaufman, L., Neve, R.L., Dietz, D.M., Shen, L., and Nestler, E.J. (2014) Essential role of poly(ADP-ribosyl)ation in cocaine action. Proc. Natl. Acad. Sci. USA 111:2005-2010. 328. Vialou, V., Bagot, R.C., Cahill, M.E., Ferguson, D., Robison, A.J., Dietz, D.M., Fallon, B., Mazei-Robison, M., Ku, S.M., Harrigan, E., Winstanley, C.A., Joshi, T., Feng, J., Berton, O., and Nestler, E.J. (2014) Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ∆FosB. J. Neurosci. 34:3878-3887. 330. Dietz, D.M., Kennedy, P.J., Sun, H.S., Maze, I., Gancarz, A.M., Vialou, V., Koo, J.W., Mouzon, E., Ghose, S., Tamminga, C.A., and Nestler, E.J. (2014) ∆FosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes. Neuropsychopharmacology 39:538-544. 331. Maze, I., Chaudhury, D., Dietz, D.M., Von Schimmelmann, M., Kennedy, P.J., Lobo, M.K., Sillivan, S.E., Miller, M.L., Bagot, R.C., Sun, H., Turecki, G., Neve, R.L., Hurd, Y.L., Shen, L., Han, M.H., Schaefer, A., and Nestler, E.J. (2014) G9a influences neuronal subtype specification in striatum. Nat. Neurosci. 17:533-539. 332. Shen, L., Shao, N.Y., and Nestler, E.J. (2014) ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC Genomics 15:284. 333. Feng, J., Wilkinson, M., Liu, X.C., Purushothaman, I., Ferguson, D., Vialou, V., Maze, I., Shao N.Y., Kennedy, P., Koo, J.W., Dias, C., Laitman, B., Stockman, V., LaPlant, Q., Cahill, M., Nestler, E.J., and Shen, L. (2014) Chronic cocaine-regualted epigenome in mouse nucleus accumbens. Genome Biol. 15:R65. 334. Mazei-Robison, M.S., Appasani, R., Edwards, S., Wee, S.M., Taylor, S., Picciotto, M.R., Koob, G.F., and Nestler, E.J. (2014) Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. PLoS One 9:e95962. 335. Robison, A.J., Vialou, V., Sun, H.S., Labonte, B., Golden, S., Dias, C., Turecki, G., Tamminga, C., Russo, S.J., Mazei-Robison, M., and Nestler, E.J. (2014) Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ∆FosB binding and antidepressant effects. Neuropsychopharmacology 39:1178-1186. 336. Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y.N., Kajitani, K., Tsuchimoto, D., Nestler, E.J., and Nakabeppu, Y. (2014) Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia 62:1284-1298. 337. Cates, H., Thibault, M., Pfau, M., Heller, E., Eagle, A., Gajewski, P., Bagot, R., Colangelo, C., Abbott, T., Rudenko, G., Neve, R., Nestler, E.J., and Robison, A.J. (2014) Threonine 149 phosphorylation enhances ∆FosB transcriptional activity to control psychomotor responses to cocaine. J. Neurosci. 34:11461-11469. 338. Donahue, R.J., Muschamp, J.W., Russo, S.R., Nestler, E.J., and Carlezon, W.A. (2014) Effects of striatal ∆FosB overexpression and ketamine on social defeat stress-induced anhedonia in mice. Biol. Psychiatry 76:550-558. 339. Der-Avakian, A., Mazei-Robison, M.S., Kesby, J.P., Nestler, E.J., and Markou, A. (2014) Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response. Biol. Psychiatry 76:542-549. 340. Arango-Lievano, M., Schwarz, J.T., Vernov, M., Wilkinson, M.B., Bradbury, K., Marongiu, R., Feliz, A., Gelfrand, Y., Warner-Schmidt, J., Nestler, E.J., Greengard, P., Russo, S.J., and Kaplitt, M.G. (2014) Cell-type specific expression of p11 controls cocaine reward. Biol. Psychiatry 76:794-801. 341. Sarkar, A., Chachra, P., Kennedy, P.J., Peña, C., Desouza L., Nestler, E.J., Vaidya, V. (2014) Hippocampal HDAC4 contributes to postnatal fluoxetine-evoked depression-like behavior. Neuropsychopharmacology 39:2221-2232.

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342. Koo, J.W., Lobo, M.K., Chaudhury, D., Labonté, B., Friedman, A., Heller, E., Peña, C.J., Han, M.-H., and Nestler, E.J. (2014) Loss of BDNF signaling in D1R expressing NAc neurons enhances morphine reward by reducing GABA inhibition. Neuropsychopharmacology 39:2646-2653. 343. Lazenka, M.F., David, B.G., Lichtman, A.H., Nestler, E.J., Selley, D.E., Sim-Selley, L.J. (2014) Delta FosB and AP1-mediated transcription modulate CB1R signaling and desensitization in striatal and limbic brain regions. Biochem. Pharmacol. 91:380-389. 345. Zhang, Y.F., Crofton, E.J., Li, D., Lobo, M.K., Fan, X.Z., Nestler, E.J., and Green, T.A. (2014) Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype, of environmental enrichment. Front. Behav. Neurosci. 8:297. 345. Ohnishi, Y.N., Ohnishi, Y.H., Vialou, V., Mouzon, E., LaPlant, Q., Nishi, A., and Nestler, E.J. (2015) Functional role of the N-terminal domain of ∆FosB in response to stress and drugs of abuse. Neuroscience 284:165-170. 346. Heller, E.A., Cates, H.M., Peña, C.J., Sun, H.S., Shao, N.Y., Feng, J., Golden, S.A., Herman, J.P., Walsh, J.J., Mazei-Robison, M., Ferguson, D., Knight, S., Gerber, M.A., Nievera, C., Han, M.H., Russo, S.J., Tamminga, C.S., Neve, R.L., Shen, L., Zhang, H.S., Zhang, F., and Nestler, E.J. (2014) Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nat. Neurosci. 17:1720-1727. 347. Dias, C., Feng, J., Sun, H.S., Shao, N.Y., Mazei-Robison, M.S., Damez-Werno, D., Scobie, K., Bagot, K., Labonte, B., Ribeiro, E., Liu, Z.C., Kennedy, P., Vialou, V., Ferguson, D., Peña, C., Calipari, E., Koo, J.W., Mouzon, E., Ghose, S., Tamminga, C., Neve, R., Shen, L., Nestler, E.J. (2014) β-Catenin mediates stress resilience through Dicer1/microRNA regulation. Nature 516:51-55. 348. Snyder, G.L., Vanover, K.E., Zhu, H., Miller, D.B., O’Callaghan, J.P., Tomesch, J., Li, P., Zhang, Q., Krishnan, V., Hendrick, J.P., Nestler, E.J., David, R.E., Wennogle, L.P., and Mates, S. (2015) Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission. Psychopharmacology 232:605-621 349. Heller, E.A., Kaska, S., Fallong, B., Ferguson, D., Kennedy, P.J., Neve, R.L., Nestler, E.J., and Mazei-Robison, M.S. (2015) Morphine and cocaine increase serum- and glucocorticioid-inducible kinase 1 activity in the ventral tegmental area. J. Neurochem. 132:243-253. 350. Ferguson, D., Shao, N.Y., Heller, E., Feng, F., Neve, R., Kim, H.D., Call, T., Magazu, S., Shen, L., and Nestler, E.J. (2015) SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens. J. Neurosci. 35:3100-3111. 351. Koo, J.W., Mazei-Robison, M.S., LaPlant, Q., Egervari, G., Braunscheidel, K.M., Adank, D.N., Ferguson, D., Feng, J., Sun, H.S., Scobie, K.N., Damez-Werno, D.M., Ribeiro, E., Peña, C.J., Walker, D., Bagot, R.C., Cahill, M.E., Anderson, S.A.R., Labonté, B., Hodes, G.E., Browne, H., Chadwick, B., Robison, A.J., Vialou, V.F., Dias, C., Lorsch, Z., Mouzon, E., Lobo, M.K., Dietz, D.M., Russo, S.J., Neve, R.L., Hurd, Y.L., and Nestler, E.J. (2015) Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat. Neurosci. 18:415-422. 352. Feng, J., Shao, N.Y., Szulwach, K.E., Vialou, V., Huynh, J., hong, C., Le, T., Ferguson, D., Cahill, M.E., Li, Y.J., Koo, J.W., Ribeiro, E., Labonté, B., Laitman, B.M., Estey, D., Stockman, V., Kennedy, P., Courousse, T., Mensah, I., Turecki, G., Faull, K.F., Song, H.J., Fan, G.P., Casaccia, P., Shen, L., Jin, P., and Nestler, E.J. (2015) Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nat. Neurosci. 18:536-544. 353. Bagot, R.C., Parise, E.M., Peña, C.J., Zhang, H.X., Maze, I., Chaudhury, D., Persaud, B., Cachope, R., Bolaños-Guzman, C.A., Cheer, J., Deisseroth, K., Han, M.H., and Nestler, E.J. (2015) Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nat. Commun. 6:7062. 354. Ohnishi, Y.H., Ohnishi, Y.N., Nakamura, T., Ohno, M., Kennedy, P.J., Yasuyaki, I., Nishi, A., Neve, R., Tsuzuki, T., and Nestler, E.J. (2015) PSMC5, a 19S proteasomal ATPase, regulates cocaine action in the nucleus accumbens. PLoS One 10:e0126710.

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355. Dias, C., Dietz, D., Mazei-Robison, M., Sun, H., Damez-Werno, D., Ferguson, D., Wilkinson, M., Magida, J., Gao, V., Neve, R., and Nestler, E.J. (2015) Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens. Neurosci. Lett. 598:23-28. 356. Covington, H.E. III, Maze, I., Vialou, V., and Nestler, E.J. (2015) Antidepressant action of HDAC inhibition in the prefrontal cortex. Neuroscience 298:329-335. 357. Massart, R., Barnea, R., Suderman, M., Meier, O., Hallet, M., Kennedy, P., Nestler, E.J., Szyf, M., and Yadid, G. (2015) Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving. J. Neurosci. 35:8042-8058. 358. Li, X., Rubio, F.J., Zeric, T., Bossert, J.M., Kambhampati, S., Cates, H.M., Kennedy, P.J., Liu, Q.-R., Cimbro, R., Hope, B.T., Nestler, E.J., and Shaham, Y. (2015) Incubation of methamphetamine craving is associated with selective increases in expression of BDNF and TrkB, glutamate receptors, and epigenetic enzymes in cue-activated Fos-expressing dorsal striatal neurons. J. Neurosci. 35:8232-8244. 359. Wright, K.N., Hollis, F., Duclot, F., Dossat, A.M., Strong, C.E., Mercer, R., Dietz, D.M., Feng, J., Francis, T.C., Lobo, M.K., Nestler, E.J., and Kabbaj, M. (2015) Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner. J. Neurosci. 358948-8958. 360. Maze, I., Wenderski, W., Noh, K.M., Bagot, R.C., Tzavaras, N., Purushothaman, I., Elsasser, S.J., Guo, Y., Ionete, C., Hurd, Y.L., Tamminga, C.A., Halene, T., Farrelly, L., Shoshnev, A.A., Wen, D., Rafii, S., Birtwistle, M.R., Akbarian, S., Buchholz, B.A., Blitzer, R.D., Nestler, E.J., Yuan, Z.F., Garcia, B.A., Shen, L., Molina, H., and Allis, C.D. (2015) Critical role of histone turnover in neuronal transcription and plasticity. Neuron 87:77-94. 361. Murgatroyd, C.A., Peña, C.J., Podda, G., Nestler, E.J., and Nephew, B.C. (2015) Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care. Neuropeptides 52:103-111. 362. Plattner, F., Hayashi, K., Hernandez, A., Benavides, D.R., Tassin, T.C., Tan, C.F., Day, J., Fina, M.W., Yuen, E.Y., Yan, Z., Goldberg, M., Nairn, A.C., Greengard, P., Nestler, E.J., Taussig, R., Nishi, A., Houslay, M.D., and Bibb, J.A. (2015) The role of ventral striatal cAMP signaling in stress-induced behaviors. Nat. Neurosci. 18:1094-1100. 363. Vialou, V., Thibault, M., Kaska, S., Cooper, S., Gajewski, P., Eagle, A., Mazei-Robison, M., Nestler, E.J., and Robison, A.J. (2015) Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress. Neuropharmacology 99:28-37. 364. Sun, H.S., Damez-Werno, D., Scobie, K.N., Shao, N.Y., Dias, C., Rabkin, J., Koo, J.W., Korb, E., Bagot, R.C., Cahill, M., Labonté, B., Mouzon, E., Heller, E.A., Cates, H., Golden, S.A., Gleason, K., Russo, S.J., Andrews, S., Neve, R., Kennedy, P.J., Maze, I., Dietz, D.M., Allis, C.D., Turecki, G., Varga-Weisz, P., Tamminga, C., Shen, L., and Nestler, E.J. (2015) ACF chromatin remodeling complex mediates stress-induced depressive-like behavior. Nat. Med. 21:1146-1153. 365. Hodes, G.E., Pfau, M.L., Purushothaman, I., Ahn, H.F., Golden, S.A., Christoffel, D.J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M., Menard, C., Aleyasin, H., Koo, J.W., Lorsch, Z.S., Feng, J., Heshmati, M., Wang, M., Turecki, G., Neve, R., Zhang, B., Shen, L., Nestler, E.J., and Russo, S.J. (2015) Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to sub-chronic variable stress. J. Neurosci. 35:16362-16376. 366. Feyder, F., Søodersten, E., Santini, E., Vialou, V., LaPlant, Q.C., Watts, E.L., Spigolon, G., Hansen, K., Caboche, J., Nestler, E.J., and Fisone, G. (2015) A role for mitogen- and stress-activated kinase 1 in L-DOPA-induced dyskinesia and ∆FosB expression. Biol. Psychiatry, in press. 367. Khibnik, L.A., Beaumont, M., Doyle, M., Heshmati, M., Slesinger, P.A., Nestler, E.J., and Russo, S.J. (2015) Stress and cocaine trigger divergent and cell type-specific regulation of synaptic transmission at single spines in nucleus accumbens. Biol. Psychiatry, in press. 368. Anacker, C., Scholz, J., O’Donnell, K.J., Allemagne-Grand, R., Diorio, J., Bagot, R., Nestler, E.J., Hen, R.,

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Lerch, J., and Meaney, M.J. (2015) Neuroanatomical differences associated with stress susceptibility and resilience. Biol. Psychiatry, in press. 369. Koo, J.W., Lagonté, B., Engmann, O., Calipari, E.S., Jaurez, B., Lorsch, Z., Walsh, J.J., Friedman, A.K., Yorgason, J.T., Han, M.H., and Nestler, E.J. (2015) Essential role of mesolimbic brain-derived neurotrophic factor in chronic social stress-induced depressive behaviors. Biol. Psychiatry, in press. 370. Calipari, E.S., Bagot, R.C., Purushothaman, I., Davidson, T.J., Yorgason, J.T., Peña, C.J., Walker, D.M., Pirpinias, S.T., Guise, K., Ramakrishnan, C., Deisseroth, K., and Nestler, E.J. (2015) In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proc. Natl. Acad. Sci. USA, in press. 371. Silverman, N.A., Popp, S., Vialou, V., Astafurov, K., Nestler, E.J., and Dow-Edward, D. (2016) Effects of Gaboxadol on the expression of cocaine sensitization in rats. Exp. Clin. Psychopharmacol., in press. Chapters and Review Articles 1. Nestler, E.J., Rainbow, T.C., McEwen, B.S., and Greengard, P. (1980) Effect of steroid hormones on protein phosphorylation in rat brain. In: Steroid Hormone Regulation of the Brain, ed. by K. Fuxe, J.A. Gustafsson, and L. Wetterberg, Pergamon Press, Oxford and New York, pp. 205-216. 2. Nestler, E.J. and Greengard, P. (1983) Protein phosphorylation in the brain. Nature 305:583-588. 3. Nestler, E.J. and Greengard, P. (1984) Protein phosphorylation in nervous tissue. In: Catecholamines. Part A: Basic and Peripheral Mechanisms, ed. by E. Usdin, A. Carlsson, A. Dahlstrom, and J. Engel, A.R. Liss, New York, pp. 9-22. 4. Nestler, E.J. and Greengard, P. (1984) Neuron-specific phosphoproteins in mammalian brain. Adv. Cyclic Nucleotide Res. 17:483-488. 5. Nestler, E.J., Walaas, S.I., and Greengard, P. (1984) Neuronal phosphoproteins: Physiological and clinical implications. Science 225:1357-1364. 6. Nestler, E.J. and Greengard, P. (1986) Synapsin I: A review of its distribution and biological regulation. Prog. Brain Res. 69:323-340. 7. Hemmings, H.C, Jr., Nestler, E.J., Walaas, S.I., Ouimet, C.C., and Greengard, P. (1987) Protein phosphorylation and neuronal function: DARPP-32, an illustrative example. In: Synaptic Function, ed. by G.M. Edelman, W.E. Gall, and W.M. Cowan, Wiley, New York, pp. 213-240. 8. Nestler, E.J. (1987) Studies of the intracellular pathways underlying acute and chronic opiate action. Yale Psychiatric Quart. 10:17-19. 9. Nestler, E.J. and Greengard P. (1988) Protein phosphorylation as a regulatory mechanism in neurons. In: Perspectives in Psychopharmacology, ed. by J.D. Barchas and W.E. Bunney, A.R. Liss, New York, 17-28. 10. Nestler, E.J. and Greengard, P. (1989) Protein phosphorylation and the regulation of neuronal function. In: Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 3rd ed., ed. by G.J. Siegel, R.W. Albers, B.W. Agranoff, and P. Molinoff, Little, Brown, and Company, Boston, pp. 373-398. 11. Nestler, E.J. (1990) Adaptive changes in signal transduction systems: Molecular mechanisms of opiate addiction in the rat locus coeruleus. In: Progress in Cell Research, Vol. 1, ed. by J.M. Ritchie, P.J. Magistretti, and L. Bolis, Elsevier, New York, pp. 73-88. 12. Duman, R.S., Nestler, E.J., Fishman, P.H., and Enna, S.J. (1990) Heterologous regulation of α- and β-adrenergic receptor function and gene expression. In: Pharmacology of Adrenergic Receptors, ed. by E. Szabdy, Birkhauser-Berlag, New York, pp. 201-210. 13. Nestler, E.J. (1991) Protein phosphorylation and the regulation of neuronal function. Neurosci. Facts, vol. 2, number 11, p. 1.

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14. Nestler, E.J. (1992) Molecular mechanisms of drug addiction. J. Neurosci. 12:2439-2450. 15. Beitner-Johnson, D. and Nestler, E.J. (1992) Basic neurobiology of cocaine: Actions within the mesolimbic dopamine system, In: Clinician's Guide to Cocaine Addiction: Theory, Research, and Treatment, ed. by T.R. Kosten and H.D. Kleber, Guilford Press, New York, pp. 55-83. 16. Beitner-Johnson, D. and Nestler, E.J. (1992) Common intracellular actions of chronic morphine and chronic cocaine in dopaminergic brain reward regions. Ann. N. Y. Acad. Sci. 654:70-87. 17. Nestler, E.J. and Beitner-Johnson, D. (1992) Common biochemical mechanisms underlying opiate and cocaine addiction, Drug News and Perspectives 5:214-222. 18. Aghajanian, G.K., Alreja, M., Nestler, E.J., Kogan, J.H. (1992) Dual mechanisms of opiate dependence in the locus coeruleus. Clin. Neuropharmacol. 15(Suppl 1 Pt A):143A-144A. 19. Harris, H.W. and Nestler, E.J. (1993) Opiate Regulation of Signal Transduction Pathways, In: The Neurobiology of Opiates, ed. by R. Hammer, CRC Press, New York, pp. 301-331. 20. Nestler, E.J., Bergson, C., Guitart, X., and Hope, B.T. (1993) Regulation of neural gene expression in opiate and cocaine addiction, In: Activation of Immediate Early Genes by Drugs of Abuse, ed. by R. Grzanna and R. Brown, NIDA Research Monograph, vol 125, p. 92-116 21. Guitart, X. and Nestler, E.J. (1993) Second messenger and protein phosphorylation mechanisms underlying opiate addiction: Studies in the rat locus coeruleus. Neurochemical Res. 18:5-13. 22. Nestler, E.J. (1993) Cellular responses to chronic treatment with drugs of abuse. Crit. Rev. Neurobiol. 7:23-39. 23. Nestler, E.J., Guitart, X., and Beitner-Johnson, D. (1993) Second messenger and protein phosphorylation mechanisms underlying opiate and cocaine addiction, In: The Biological Basis of Substance Abuse, UCLA/NIDA Symposium, ed. by S.G. Korenman and J.D. Barchas, Oxford University Press, pp. 49-69. 24. Nestler, E.J. (1993) Molecular mechanisms of drug addiction in the mesolimbic dopamine pathway. Seminars in the Neurosciences 5:369-376. 25. Nestler, E.J., Hope, B.T., and Widnell, K.L. (1993) Drug addiction: A model for the molecular basis of neural plasticity, Neuron 11:995-1006. 26. Duman, R. and Nestler, E.J. (1994) G-proteins and cyclic nucleotides in the nervous system, In: Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 5th ed., ed. by G.J. Siegel, R.W. Albers, B.W. Agranoff, and P. Molinoff, Little, Brown, and Company, Boston, pp. 429-448. 27. Nestler, E.J. and Greengard, P. (1994) Protein phosphorylation and the regulation of neuronal function, In: Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 5th ed., ed. by G.J. Siegel, R.W. Albers, B.W. Agranoff, and P. Molinoff, Little, Brown, and Company, Boston, pp. 449-474. 28. Nestler, E.J., Guitart, X., Ortiz, J., and Trevisan, L. (1994) Second messenger and protein phosphorylation mechanisms underlying possible genetic vulnerability to alcoholism. Ann. N. Y. Acad. Sci. 708:108-118. 29. Duman, R.S. and Nestler, E.J. (1994) Signal transduction pathways for catecholamine receptors, In: Psychopharmacology: Fourth Generation of Progress, ed. by F.E. Bloom and D.J. Kupfer, Raven Press, New York, pp 303-320. 30. Nestler, E.J. and Duman, R.S. (1994) Intracellular messenger pathways as mediators of neural plasticity, In: Psychopharmacology: Fourth Generation of Progress, ed. by F.E. Bloom and D.J. Kupfer, Raven Press, New York, pp 695-704. 31. Sklair-Tavron, L., Nestler, E.J., and Segal, M. (1994) Locus coeruleus (LC) - target interaction and cAMP in control of LC development. Brain Res. Bull. 35:397-402.

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32. Nestler, E.J., Alreja, M., and Aghajanian, G.K. (1994) Molecular and cellular mechanisms of opiate action: Studies in the rat locus coeruleus. Brain Res. Bull. 35:521-528. 33. Nestler, E.J. (1994) Molecular neurobiology of drug addiction. Neuropsychopharmacology 11:77-87. 34. Nestler, E.J. (1994) Hard target: Understanding dopaminergic neurotransmission. Cell 79:923-926. 35. Nestler, E.J. (1995) Neuroscience, In: Core Readings in Psychiatry: An Annotated Guide to the Literature, 2nd Ed., ed. by M.H. Sacks, W.H. Sledge, C. Warren, American Psychiatric Press, Washington, D.C., pp. 3-18. 36. Nestler, E.J. and Hyman, S.E. (1995) Intraneuronal signaling pathways, In: Comprehensive Textbook of Psychiatry, 6th Ed., ed. by H.I. Kaplan and B.J. Sadock, Williams and Wilkins, Baltimore, Chapter 1.6, pp. 52-64. 37. Hyman, S.E. and Nestler, E.J. (1995) Basis molecular neurobiology, In: Comprehensive Textbook of Psychiatry, 6th Ed., ed. by H.I. Kaplan and B.J. Sadock, Williams and Wilkins, Baltimore, Chapter 1.14, pp. 136-144. 38. Nestler, E.J. (1995) Molecular mechanisms of drug addiction: Clinical implications, In: Clinical Neurobiology of Drug Addiction, ed. by R.J. Chiarello, NIDA Research Monograph. 39. Self, D.W. and Nestler, E.J. (1995) Molecular mechanisms of drug reinforcement and addiction. Annu. Rev. Neurosci. 18:463-495. 40. Duman, R.S., Heninger, G.R., and Nestler, E.J. (1995) Molecular psychiatry: Adaptations of receptor-coupled signal transduction pathways underlying stress- and drug-induced neural plasticity. J. Nerv. Mental Dis. 182:692-700. 41. Fitzgerald, L. and Nestler, E.J. (1995) Cocaine Regulation of Signal Transduction Pathways. In: Molecular and Cellular Neurobiology of Cocaine, ed. by R. Hammer, CRC Press, New York, pp. 225-246. 42. Nestler, E.J., Fitzgerald, L.W., and Self, D.W. (1995) Neurobiology of substance abuse. In: APA Annual Review of Psychiatry, volume 14, American Psychiatric Press, Washington, D.C., 14:51-81. 43. Nestler, E.J. (1995) Molecular basis of addictive states. The Neuroscientist 1:212-220. 44. Fitzgerald, L.W. and Nestler, E.J. (1995) Molecular and cellular adaptations in signal transduction pathways following ethanol exposure. Clin. Neurosci. 3:165-173. 45. Hope, B.T., Nye, H.E., Kelz, M.B., and Nestler, E.J. (1996) Induction of a long-lasting AP-1 complex of altered Fos-like proteins in brain by chronic cocaine. In: Colloque Scientifique International 1994, ed. by H. Baylon, Academie Nationale de Medicine, Paris, pp. 333-343. 46. Hyman, S.E. and Nestler, E.J. (1996) Initiation and adaptation: A paradigm to understand psychotropic drug action. Am. J. Psychiatry 153:151-162. 47. Russell, D.S., Widnell, K.L., and Nestler, E.J. (1996) Antisense oligonucleotides: New tools for the study of brain function. The Neuroscientist 2:79-82. 48. Nestler, E.J. (1996) Under siege: The brain on opiates. Neuron 16:897-900. 49. Nestler, E.J. and Duman, R.S. (1996) Molecular mechanisms of neural plasticity: Adaptations in Intracellular Messenger Pathways. In: APA Annual Review of Psychiatry, volume 15, American Psychiatric Press, Washington, D.C., pp. 279-309. 50. Nestler, E.J., Berhow, M.T., and Brodkin, E.S. (1996) Molecular mechanisms of drug addiction: Adaptations in signal transduction pathways. Mol. Psychiatry 1:190-199. 51. Widnell, K.L. and Nestler, E.J. (1997) Molecular correlates of drug addiction: Studies on Opiate Action. In: Drug Abuse in the Decade of the Brain, ed. by G. Nahas and T.F. Burks, IOS Press, pp. 55-59.

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52. Hiroi, N., Chen, J.S., Nye, H.E., and Nestler, E.J. (1997) Chronic FRAs: Novel trans-cription factors regulated in the basal ganglia by chronic neuronal perturbations. In: Basal Ganglia V, ed. by C. Ohyo, M. Kimura, and J. McKenzie, Raven Press, New York, pp. 401-408. 53. Duman, R.S., Heninger, G.R., and Nestler, E.J. (1997) A molecular and cellular hypothesis of depression. Arch. Gen. Psychiatry 54:597-606. 54. Koob, G.F. and Nestler, E.J. (1997) Neurobiology of drug addiction. J. Neuropsychiatry Clin. Neurosci. 9:482-497. 55. Hiroi, N. and Nestler, E.J. (1997) Nuclear memory: gene, transcription, and behavior. Adv. Pharmacol. 42:1037-1041. 56. Nestler, E.J. and Aghajanian, G.K. (1997) Molecular and cellular basis of addiction. Science 278:58-63. 57. Nestler, E.J. (1997) Molecular mechanisms underlying opiate addiction: Implications for medications development. Sem. Neurosci. 9:84-93. 58. Nestler, E.J. and Self, D.W. (1997) Neurobiological aspects of ethanol and other drug dependencies. In: Textbook of Neuropsychiatry, ed. by S.C. Yudofsky and R.E. Hales, American Psychiatric Press, Washington, D.C., 1997, pp 773-798. 59. Widnell, K.L. and Nestler, E.J. (1997) Molecular mechanisms of opiate addiction in the nucleus accumbens: Morphine regulation of G proteins. In: Neuromethods, Vol. 31: G Protein Methods and Protocols, ed. by R.K. Mishra, G.B. Baker, and A.A. Boulton, Humana Press, Totowa, New Jersey, pp. 189-205. 60. Nestler, E.J. (1997) Molecular mechanisms of opiate and cocaine addiction. Curr. Op. Neurobiol. 7:713-719. 61. Nestler, E.J. (1997) Basic neurobiology of opiate addiction. In: New Treatments for Opiate Dependence, ed. By S.M. Stine and T.R. Kosten, Guilford Publications, New York, pp. 34-61. 62. Self, D.W. and Nestler, E.J. (1998) Relapse to drug seeking: Neural and molecular mechanisms. Drug Alcohol Dependence 51:49-60. 63. Brodkin, E.S. and Nestler, E.J. (1998) Quantitative trait locus analysis: A new tool for psychiatric genetics. The Neuroscientist 4:317-323. 64. Nestler, E.J. (1998) Antidepressant treatments in the 21st century. Biol. Psychiatry 44:526-533. 65. Nestler, E.J. and Duman, R.S. (1999) G proteins, In: Basic Neurochemistry, 6th ed., ed. by G.J. Siegel, B.W. Agranoff, R.W. Alberts, S.K. Fisher, and M.D. Uhler, Lippincott-Raven Publishers, pp. 401-414. 66. Duman, R.S. and Nestler, E.J. (1999) Cyclic nucleotides, In: Basic Neurochemistry, 6th ed., ed. by G.J. Siegel, B.W. Agranoff, R.W. Alberts, S.K. Fisher, and M.D. Uhler, Lippincott-Raven Publishers, pp. 433-452. 67. Nestler, E.J. and Greengard, P. (1999) Serine and threonine phosphorylation, In: Basic Neurochemistry, 6th ed., ed. by G.J. Siegel, B.W. Agranoff, R.W. Alberts, S.K. Fisher, and M.D. Uhler, Lippincott-Raven Publishers, pp. 471-496. 68. Sklair-Tavron, L. and Nestler, E.J. (1999) Locus coeruleus, In: The Neuron in Tissue Culture, ed. by L.W. Haynes, John Wiley & Sons, New York, pp. 461-466. 69. Nestler, E.J. and Hyman, S.E. (1999) Mechanisms of neural plasticity, In: Neurobiological Foundations of Psychiatry, ed. by D.S. Charney, E.J. Nestler, and B.S. Bunney, Oxford University Press, pp. 61-72. 70. Hyman, S.E. and Nestler, E.J. (1999) Principles of molecular biology, In: Neurobiological Foundations of Psychiatry, ed. by D.S. Charney, E.J. Nestler, and B.S. Bunney, Oxford University Press pp. 73-85. 71. Nestler, E.J. (1999) Molecular mechanisms of drug addiction, In: Neurobiological Foundations of Psychiatry, ed. by D.S. Charney, E.J. Nestler, and B.S. Bunney, Oxford University Press, pp. 578-590.

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72. Nestler, E.J., Kelz, M.B., and Chen, J.S. (1999) ∆FosB: A molecular mediator of long-term neural and behavioral plasticity. Brain Res. 835:10-17. 73. Nestler, E.J., Alreja, A., and Aghajanian, G.K. (1999) Molecular control of locus coeruleus neurotransmission. Biol. Psychiatry 46:1131-1139. 74. Duman, R.S. and Nestler, E.J. (2000) Role of gene expression in stress and drug induced neural plasticity. The Economics of Neuroscience 2:53-58. 75. Nestler, E.J. (2000) Neuroadaptation in Addiction. In: Principles of Addiction Medicine, ed. by A.W. Graham and T.K. Schultz, American Society of Addiction Medicine, Chevy Chase, MD. 76. Nestler, E.J. and Olivier, B. (2000) Use of transgenic tools in CNS drug discovery. Curr. Protocols Pharmacol. 5.20:1-8. 77. Nestler, E.J. (2000) Genes and addiction. Nat. Gen. 26:277-281. 78. Kelz, M.B. and Nestler, E.J. (2000) ∆FosB: A molecular switch underlying long-term neural plasticity. Curr. Op. Neurol. 13:715-720. 79. Nestler, E.J. and Duman, R.S. (2000) Intracellular Messenger Pathways as Mediators of Neural Plasticity, In: Fourth Generation of Progress, CD-ROM version, http://www.acnp.org/citations/GN401000067. 80. Calon, F., Hadj Tahar, A., Blanchet, P.J., Morissette, M., Grondin, R., Goulet, M., Doucet, J.P., Robertson, G.S., Nestler, E., Di Paolo, T., Bedard, P.J. (2000) Dopamine-receptor stimulation: biobehavioral and biochemical consequences. Trends Neurosci. 23(10 Suppl):S92-S100. 81. Nestler, E.J. (2001) Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci. 2:119-128. 82. Carlezon, W.A. Jr., Nestler, E.J., and Neve, R.L. (2001) Viral-mediated gene transfer as a tool for neuropsychiatric research. Crit. Rev. Neurobiol. 14:47-67. 83. Nestler, E.J. (2001) Total recall: The memory of addiction. Science 292:2266-2267. 84. Nestler, E.J., Barrot, M., Self, D.W. (2001) ∆FosB: A molecular switch for addiction. Proc. Natl. Acad. Sci. USA 98:11042-11046. 85. Nestler, E.J. (2001) Molecular neurobiology of addiction. Am. J. Addiction 201:201-217. 86. Nestler, E.J. (2001) Psychogenomics: Opportunities for understanding drug addiction. J. Neurosci. 21:8324-8327. 87. Nestler, E.J. (2002) Dopamine and gene expression. In: Handbook of Experimental Pharmacology, Dopamine in the CNS I, ed. by D. Di Chiara, Springer, Heidelberg, pp. 321-339. 88. Nestler, E.J. and Hyman, S.E. (2002) Regulation of gene expression. In: Fifth Generation of Progress, ed. by K.L. Davis, D.S. Charney, J.T. Coyle, and C. Nemeroff, Lippincott Williams and Wilkins, New York, Chapter 17, pp. 217-228. 89. Nestler, E.J. and Self, D.W. (2002) The neurobiology of ethanol and other chemical dependencies. In: Textbook of Neuropsychiatry, ed. by S.C. Yudofsky and R.E. Hales, American Psychiatric Press, Washington, D.C., pp. 899-921. 90. Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J., and Monteggia, L.M. (2002) Neurobiology of depression. Neuron 34:13-25. 91. Charney, D.S., Barlow, D.H., Botteron, K., Cohen, J.D., Goldman, D., Gur, R.E., Lin, K.-M., Lopez, J.F., Meador-Woodruff, J.H., Moldin, S.O., Nestler, E.J., Watson, S.J., and Zalcman, S.J. (2002) Neuroscience research

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agenda to guide development of a pathophysiologically based classification system. In: A Research Agenda for DSM-V, ed. by D.J. Kupfer, M.B. First, and D.A. Regier, American Psychiatric Press, New York, pp. 31-83. 92. Nestler, E.J., Gould, E., Manji, H.K., and the NIH Strategic Planning Committee on Mood Disorders, Preclinical Workgroup (2002) Preclinical models: Status of basic research in depression. Biol. Psychiatry 52:503-528. 93. Brunner, D., Nestler, E.J., and Leahy, E. (2002) In need of highthroughput behavioral systems. Drug Disc. Today 7(suppl.):S107-S112. 94. Nestler, E.J. (2002) From neurobiology to treatment: Progress against addiction. Nat. Neurosci. 5(suppl):1076-1079. 95. Carlezon, W.A., Jr. and Nestler, E.J. (2002) Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci. 25:610-615. 96. Nestler, E.J. (2002) Common molecular and cellular substrates of addiction and memory. Neurobiol. Learning Memory 78:637-647. 97. Nestler, E.J., DiLeone, R.J., and Monteggia, L.M. (2002) Inducible, cell-targeted mutations in mice: New tools for genetically dissecting behavior. Int. J. Comp. Psychol. 14:111-122. 98. Eisch, A.J. and Nestler, E.J. (2002) To be or not to be: Role of adult neurogenesis in psychiatry. J. Clin. Neurosci. 2:93-108. 99. Nestler, E.J. (2003) Molecular mechanisms of drug addiction. In: Molecular Neurobiology for the Clinician, ed. by D.S. Charney, American Psychiatric Press, pp. 107-121. 100. DiLeone, R.J., Georgescu, D., and Nestler, E.J. (2003) Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci. 73:759-768. 101. Nestler, E.J. (2003) From neurobiology to treatment: Progress against addiction. In: ASAM’s Principle s of Addiction Medicine, 3rd Ed., by A.W. Graham, T.K. Schultz, A.F. Mayo-Smith, and R.K. Ries, ASAM Publications, pp. 73-78. (Note: This chapter represents a reprint of reference 93 above.) 102. Nestler, E.J. (2003) Clinical Neuroscience: A Great Choice for MD/PhD Students. Science Next Wave, http://nextwave.sciencemag.org/cgi/content/full/2003/10/08/4?. 103. Nestler, E.J. and Hyman, S.E. (2004) Mechanisms of neural plasticity, In: Neurobiology of Mental Illness, 2nd Ed., ed. by D.S. Charney and E.J. Nestler, Oxford University Press, pp. 66-75. 104. Hyman, S.E. and Nestler, E.J. (2004) Principles of molecular biology, In: Neurobiology of Mental Illness, 2nd Ed., ed. by D.S. Charney and E.J. Nestler, Oxford University Press, pp. 76-86. 105. Nestler, E.J. (2004) Molecular mechanisms of drug addiction, In: Neurobiology of Mental Illness, 2nd Ed., ed. by D.S. Charney and E.J. Nestler, Oxford University Press, pp. 698-709. 106. Chao, J. and Nestler, E.J. (2004) Molecular neurobiology of drug addiction. Annu. Rev. Med. 55:113-132. 107. Bolanos, C.A. and Nestler, E.J. (2004) Neurotrophic mechanisms in drug addiction. J. Neuromol. Med. 5:69-83. 108. Nestler, E.J. and Malenka, R.C. (2004) The addicted brain. Sci. Am., March 2004, pp. 78-85. 109. Nestler, E.J. (2004) Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol. Sci. 25:210-218. 110. Tecott, L.H. and Nestler, E.J. (2004) Neurobehavioral assessment in the information age. Nat. Neurosci. 7:462-466.

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111. Nestler, E.J. (2004) Molecular mechanisms of drug addiction. Special issue celebrating NIDA’s 30th Anniversary, ed. by D. Shurtlehuff, R. Liu, and C. Sasek. Neuropharmacology, 47S1:24-32. 112. McClung, C.A., Ulery, P.G., Perrotti, L.I., Zachariou, V., Berton, O., and Nestler, E.J. (2004) ∆FosB: A molecular switch for long-term adaptation in the brain. Mol. Brain Res. 132:146-154. 113. Neve, R.L., Neve, K.A., Nestler, E.J., and Carlezon, W.A., Jr. (2005) Use of herpes virus amplicon vectors to study brain disorders. BioTechniques 39:381-391. 114. Carlezon, W.A., Jr., Duman, R.S., and Nestler, E.J. (2005) The many faces of CREB. Trends Neurosci. 28:436-445. 115. Colvis, C.M., Pollock, J.D., Goodman, R.H. Impey, S., Dunn, J., Mandel, G., Champagne, F.A., Mayford, M., Korzus, E., Kumar, A., Renthal, W., Theobald, D.E.H., and Nestler, E.J. (Conference Report) (2005) Epigenetic mechanisms and gene networks in the nervous system. J. Neurosci. 25:10379-10389. 116. Nestler, E.J. (2005) Is there a common molecular pathway for addiction? Nat. Neurosci. 8:1445-1449. 117. Nestler, E.J. (2005) The neurobiology of cocaine addiction. Sci. Practice Perspectives 3:4-12. 118. McClung, C.A. and Nestler, E.J. (2005) Stimulus-dependent regulation of gene expression in the nervous system. In: Databasing the Brain: From Data to Knowledge (Neuroinformatics), ed. by S.H. Koslow and S. Subramaniam, Wiley, pp. 191-203. 119. Green, T.A. and Nestler, E.J. (2006) Psychiatric applications of viral vectors. In: Gene Therapy in the Central Nervous System, ed. by M.G. Kaplitt and M. During, Elsevier, Oxford UK, pp. 181-193. 120. Berton, O. and Nestler, E.J. (2006) New approaches to antidepressant drug discovery: Beyond monoamines. Nat. Rev. Neurosci. 7:137-151. 121. Nestler, E.J. (2006) Molecular mechanisms of drug addiction. In: Cell Biology of Addiction, ed. by B.K. Madras, C.M. Colvis, J.D. Pollock, J.L. Rutter, D. Shurtleff, and M. von Zastrow, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 393-412. 122. Nestler, E.J. and Carlezon, W.A., Jr. (2006) The mesolimbic dopamine reward circuit in depression. Biol. Psychiatry 59:1151-1159. 123. Hyman, S.E., Malenka, R.C., and Nestler, E.J. (2006) Neural mechanisms of addiction: The role of reward-related learning and memory. Annu. Rev. Neurosci. 29:565-598. 124. Nestler, E.J. (2006) The addicted brain: Cocaine use alters genes. Paradigm, Summer 2006, pp. 12-22. 125. Nestler, E.J. and Chao, J. (2006) Disorders of substance dependence. In: Principles of Molecular Medicine, 2nd ed., ed. by M.S. Rune and C. Patterson, Humana Press, pp. 1220-1227. 126. Nestler, E.J. and Duman, R.S. (2006) G proteins. In: Basic Neurochemistry, 7th Ed., ed. by G.J. Siegel, R.W. Albers, S.T. Brady, and D.L. Price, Academic Press, New York, pp. 335-346. 127. Duman, R.S. and Nestler, E.J. (2006) Cyclic nucleotides in the nervous system. In: Basic Neurochemistry, 7th Ed., ed. by G.J. Siegel, R.W. Albers, S.T. Brady, and D.L. Price, Academic Press, New York, pp. 361-378. 128. Bibb, J.A. and Nestler, E.J. (2006) Serine and threonine phosphorylation. In: Basic Neurochemistry, 7th Ed., ed. by G.J. Siegel, R.W. Albers, S.T. Brady, and D.L. Price, Academic Press, New York, pp. 391-414.

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129. Tsankova, N., Renthal, W., Kumar, A., and Nestler, E.J. (2007) Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8:355-367. 130. Nestler, E.J. and Self, D.W. (2008) Neuropsychiatric Aspects of Ethanol and Other Chemical Dependencies. In: Neuropsychiatry and Behavioral Neurosciences, ed. by S.C. Yudofsky and R.E. Hales, 5th Ed., American Psychiatric Press, pp. 881-905. 131. McClung, C.A. and Nestler, E.J. (2008) Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 33:3-17. 132. Nestler, E.J. (2008) Commentary on Radioligand binding methodologies: New inventions. In: Science and Psychiatry: Groundbreaking Discoveries in Molecular Neuroscience, ed. by S.H. Snyder, American Psychiatric Press, Washington, D.C., pp. 3-7. 133. Renthal, W. and Nestler, E.J. (2008) Epigenetic mechanisms in drug addiction. Trends Mol. Med. 14:341-350. 134. Nestler, E.J. (2008) Transcriptional mechanisms of addiction: role of deltaFosB. Philos. Trans. R. Soc. London, B Biol. Sci. 363:3245-3255. 135. Krishnan, V. and Nestler, E.J. (2008) Molecular neurobiology of depression. Nature 455:894-902. 136. Jiang, Y., Langley, B., Lubin, F.D., Renthal, W., Wood, M.A., Yasui, D.H., Kumar, A., Nestler, E.J., Akbarian, S., and Beckel-Mitchener, A.C. (2008) Epigenetics in the nervous system. J. Neurosci. 28:11753-11759. 137. Russo, S.J., Mazei-Robison, M.S., Ables, J.L., and Nestler, E.J. (2008) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56:73-82. 138. Borrelli, E., Nestler, E.J., Allis, C.D., and Sassone-Corsi, P. (2008) Decoding the epigenetic language of neuronal plasticity. Neuron 60:961-974. 139. Nestler, E.J. and Tecott, L.H. (2008) Rodent behaviour: Approaches. In: Encyclopedia of Neuroscience, ed. by L.R. Squire, Academic Press, Oxford, Ch 887, vol. 8, pp. 407-413. 140. Nestler, E.J. and Hyman, S.E. (2009) Mechanisms of neural plasticity. In: Neurobiology of Mental Illness, 3nd Ed., ed. by D.S. Charney and E.J. Nestler, Oxford University Press, pp. 66-75.

141. Hyman, S.E. and Nestler, E.J. (2009) Principles of molecular biology. In: Neurobiology of Mental Illness, 3nd Ed., ed. by D.S. Charney and E.J. Nestler, Oxford University Press, pp. 76-87. 142. Nestler, E.J. (2009) Cellular and molecular mechanisms of drug addiction. In: Neurobiology of Mental Illness, 3nd Ed., ed. by D.S. Charney and E.J. Nestler, Oxford University Press, pp. 775-785. 143. Berton, O. and Nestler, E.J. (2009) Novel targets for antidepressant treatments. In: Neurobiology of Mental Illness, 3nd Ed., ed. by D.S. Charney and E.J. Nestler, Oxford University Press, pp. 530-543.

144. Lutter, M. and Nestler, E.J. (2009) Homeostatic and hedonic signals interact in the regulation of food intake. J. Nutr. 139:629-632. 145. Feder, A., Nestler, E.J., and Charney, D.S. (2009) Psychobiology and molecular genetics of resilience. Nat. Rev. Neurosci. 10:446-457. 146. Renthal, W. and Nestler, E.J. (2009) Histone acetylation in drug addiction. Sem. Cell Dev. Biol. 20:387-394. 147. Dietz, D.M., Dietz, K.C., Nestler, E.J., and Russo, S.J. (2009) Molecular mechanisms of psychostimulant-induced structural plasticity. Pharmacopsychiatry 42(Suppl 1):S69-S78. 148. Winstanley, C.A. and Nestler, E.J. (2009) Molecular mechanisms of reward. In: Learning and Memory: A Comprehensive Reference, ed. by J. Byrne and D. Sweatt, Elsevier, pp. 193-215.

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149. Renthal, W. and Nestler, E.J. (2009) Chromatin mechanisms in drug addiction and depression. Dialogues Clin. Neurosci. 11:257-268. 150. Covington, H.E. III, Vialou, V., and Nestler, E.J. (2010) Emerging pharmacotherapies for treating depression. Neuropharmacology 58:683-693. 151. Russo, S.J., Dietz, D.M., Dumitriu, D., Morrison, J.H., Malenka, R.C., and Nestler, E.J. (2010) The addicted synapse: Mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci. 33:267-276. 152. Bale, T.L., Baram, T.Z., Brown, A.S., Goldstein, J.M., Insel, T.R., McCarthy, M.M., Nemeroff, C.B., Reyes, T.M., Simerly, R.B., Susser, E.Z., and Nestler, E.J. (2010) Early life programming and neurodevelopmental disorders. Biol. Psychiatry 68:314-319. 153. Nestler, E.J. and Hyman, S.E. (2010) Animal models of neuropsychiatric disorders. Nat. Neurosci. 13:1161-1169. 154. Bale, T.L., Baram, T.Z., Brown, A.S., Goldstein, J.M., Insel, T.R., McCarthy, M.M., Nemeroff, C.B., Reyes, T.M., Simerly, R.B., Susser, E.Z., and Nestler, E.J. (2010) Early life programming and neurodevelopmental disorders. Biol. Psychiatry 68:314-319. 155. Feng, J. and Nestler, E.J. (2010) MeCP2 and drug addiction. Nat. Neurosci. 13:1039-1041. 156. Krishnan, V. and Nestler, E.J. (2010) Linking molecules to mood: New insight into the biology of depression. Am. J. Psychiatry 167:1305-1320. 157. Maze, I. and Nestler, E.J. (2010) The epigenetic landscape of addiction. Ann. N.Y. Acad. Sci. 1216:99-113. 158. Lester, B.M., Tronick, E., Nestler, E., Abel, T., Kosofsky, B., Kuzawa, C.W., Marsit, C.J., Maze, I., Meaney, M.J., Monteggia, L.M., Reul, J.M., Skuse, D.H., Sweatt, J.D., and Wood, M.A. (2011) Behavioral epigenetics. Ann. N. Y. Acad. Sci. 1226:14-33. 159. LaPlant, Q. and Nestler, E.J. (2011) CRACKing the histone code: Cocaine’s effects on chromatin structure and function. Hormones Behav. 59:321-330. 160. Krishnan, V. and Nestler, E.J. (2011) Animal models of depression: Molecular perspectives. Curr. Topics. Behav. Neurosci. 7:121-147. 161. Lobo, M.K. and Nestler, E.J. (2011) The striatal balancing act in drug addiction: distinct roles of direct andi pathway medium spiny neurons. Front. Neuroanat. 5:41. 162. Marder S.R., Roth, B., Sullivan, P.F., Scolnick, E.M., Nestler, E.J., Geyer, M.A., Weinberger, D.R., Karayiorgou, M., Buidotti, A., Gingrich, J., Akbarian, S., Buchanan, R.W., Lieberman, J.A., Conn, P.J., Haggarty, S.J., Law, A.J., Campbell, B., Krystal, J.H., Moghadam, B., Sawa, A., Caron, M.G., George, S.R., Allen, J.A., and Solis, M. (2011) Advancing drug discovery for schizophrenia. Ann. N.Y. Acad. Sci. 1236:30-43. 163. Robison, A.J. and Nestler, E.J. (2011) Transcriptional and epigenetic mechanisms of addiction. Nat. Rev. Neurosci. 12:623-637. 164. Nestler, E.J. (2011) Hidden switches in the mind. Sci. Am., Dec. 2011, pp. 76-83. 165. Messing, R.O., Rubenstein, J.H., and Nestler, E.J. (2011) Biology of psychiatric disorders, In: Harrison’s Principles of Internal Medicine, Ed. by D.L. Longo, D.L. Kasper, J.L. Jameson, A.S. Fauci, S.L. Hauser, and J. Loscalzo, 18th Ed., Chap 390, pp. 3522-3529. 166. Mason, B.L., Nestler, E.J., and Lutter, M. (2012) Feeding systems and drugs of abuse. In: Food and Addiction: A Comprehensive Handbook, ed. by K. Brownell and M. Gold, Oxford University Press, pp. 40-46. 167. Dietz, D.M. and Nestler, E.J. (2012) From father to offspring: paternal transmission of depressive-like behaviors. Neuropsychopharmacology 37:311-312.

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168. Lobo, M.K., Nestler, E.J., and Covington, H.E. 3rd (2012) Potential utility of optogenetics in the study of depression. Biol. Psychiatry 71:1068-1074. 169. Russo, S.J., Murrough, J.W., Han, M.H., Charney, D.S., and Nestler, E.J. (2012) Neurobiology of resilience. Nat. Neurosci. 15:1475-1484. 170. Mazei-Robison, M.S. and Nestler, E.J. (2012) Opiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons. In: Additional Perspectives on Addiction, ed. by R.C. Pierce and P.J. Kenny, Cold Spring Harbor Laboratory Press, pp. 153-168. 171. Nestler, E.J. (2012) Transcriptional mechanisms of drug addiction. Clin. Psychopharmacol. Neurosci. 10:136-143. 172. Vialou, V., Feng, J., Robison, A.J., and Nestler, E.J. (2013) Epigenetic mechanisms of depression and antidepressant action. Annu. Rev. Pharmacol. Toxicol. 53:59-87. 173. Sweatt, J.D., Nestler, E.J., Meaney, M.J., and Akbarian, S. (2013) An overview of the molecular basis of epigenetics. In: Epigenetic Regulation in the Nervous System, ed. by J.D. Sweatt, E.J. Nestler, M.J. Meaney, and S. Akbarian, Academic Press, pp. 1-33. 174. Robison, A.J., Feng, J., and Nestler, E.J. (2013) Drug addiction and reward. In: Epigenetic Regulation in the Nervous System, In: Epigenetic Regulation in the Nervous System, ed. by J.D. Sweatt, E.J. Nestler, M.J. Meaney, and S. Akbarian, Academic Press, pp. 172-195. 175. Sweatt, J.D., Meaney, M.J., Nestler, E.J., and Akbarian, S. (2013) Epigenetics: Defining the frontiers of genomice function, In: Epigenetic Regulation in the Nervous System, ed. by J.D. Sweatt, E.J. Nestler, M.J. Meaney, and S. Akbarian, Academic Press, pp. 340-354. 176. Sun, H.S., Kennedy, P.J., and Nestler, E.J. (2013) Epigenetics of the depressed brain: Role of histone acetylation and methylation. Neuropsychopharmacology Rev. 38:124-137. 177. Nestler, E.J. (2013) Treating the brain deep down: Brain surgery for anorexia nervosa? Naure. Med. 19:678-679. 178. Shen, L., Choi, I., Nestler, E.J., and Won, K.-J. (2013) Human transcriptome and chromatin modifications: An ENCODE perspective. Genomics Informatics 11:60-67. 179. Feng, J. and Nestler, E.J. (2013) Epigenetic mechanisms of drug addiction. Curr. Op. Neurobiol. 23:521-528. 180. Nestler, E.J. (2013) Cellular basis of memory for addiction. Dialogues Clin. Neurosci. 15:431-443. 181. Abul-Husn, N.S. and Nestler, E.J. (2013) Genetics of drug addiction. In: Clinical Genomics, ed. by. M.F. Murray and M.A. Giovanni, McGraw-Hill, New York, pp. 681-685. 182. Nestler, E.J. (2014) Epigenetic mechanisms of drug addiction. Neuropharmacology 76:259-268. 183. Nestler, E.J. (2014) Epigenetic mechanisms of psychiatry. JAMA Psychiatry 71:454-456. 184. Dong, Y. and Nestler, E.J. (2014) The neural rejuvenation hypothesis of cocaine addiction. Trends Pharmacol. Sci. 35:374-383. 184. Peña, C.J., Bagot, R.C., Labonté, B., and Nestler, E.J. (2014) Epigenetic signaling in psychiatric disorders. J. Mol. Biol. 426:3389-3412. 185. Bagot, R.C., Labonte, B., Peña, C.J., and Nestler, E.J. (2014) Epigenetic signaling in psychiatric disorders: stress and depression. Dialogues Clin. Neurosci. 16:281-295.

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186. Maze, I., Shen, L., Zhang, B., Garcia, B.A., Shao, N.Y., Mitchell, A., Sun, H.S., Akbarian, S., Allis, C.D., and Nestler, E.J. (2014) Analytical tools and current challenges in the modern era of neuroepigenomics. Nat. Neurosci. 17:1476-1490. 187. Walker, D.M., Cates, H.M., Heller, E.A., and Nestler, E.J. (2014) Regulation of chromatin states by drugs of abuse. Curr. Opin. Neurobiol. 30C:112-121. 188. Descalzi, G., Ikegami, D., Ushijima, T., Nestler, E.J., Zachariou, V., and Narita, M. (2015) Epigenetic mechanisms of chronic pain. Trends Neurosci. 38:237-246. 189. Nestler, E.J. (2015) ∆FosB: a transcriptional regulator of stress and antidepressant responses. Eur. J. Pharmacol. 753:66-72. 190. Nestler, E.J. (2015) From neurobiology to treatment: Progress against addiction. In: ASAM’s Principles of Addiction Medicine, 3rd Ed., by A.W. Graham, T.K. Schultz, A.F. Mayo-Smith, and R.K. Ries, ASAM Publications, pp. 28-35. 191. Messing, R.O. and Nestler, E.J. (2015) Biology of psychiatric disorders. In: Harrison’s Principles of Internal Medicine, Ed. by D.L. Kasper, S.L. Hauser, J.L. Jameson, A.S. Fauci, D.L. Longo, and J. Loscalzo, 19th Ed., Chap 465e. 192. Nestler, E.J. and Hyman, S.E. (2015) Biology of addiction. In: Goldman-Cecil Medicine, ed. by L. Goldman and A.I. Schafer, 25th Ed., Chap 31, pp. 143-145. 193. Nestler, E.J. (2015) Role of the brain’s reward circuitry in depression: Transcriptional mechanisms. Int. Rev. Neurobiol. 124:151-170. 194. Nestler, E.J. (2015) Reflections on: "A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic ations of morphine and cocaine on neuronal function". Brain Res., in press. 195. Shen, L., Feng, J., and Nestler, E.J. (2015) Profiling drug-induced chromatin modification landscapes in mouse brain by ChIP-seq. In: Bioinformatic Methods in Biological Psychiatry,” ed. by A.V. Kalueff and A.M. Stewart, Elsevier, in press. 196. Greally, J.M. and Nestler, E.J. (2015) Neuroepigenomics and human disease. In: Genomics, Circuits, and Pathways for the Clinical Neuroscientist, edited by M. State, B. Miller, and T. Lehner, Elsevier, in press. 197. Feng, J. and Nestler, E.J. (2015) Epigenetic modifications of DNA and drug addiction. In: DNA Modifications and the Epigenome in the Brain, ed. by T.W. Bredy, Elsevier, in press. Case Reports, Letters, News and Views, and Book Reviews 1. Nestler, E.J. (1990) The case of double supervision: A resident's perspective of psychiatric supervision. Academic Psychiatry 14:129-136. 2. Nestler, E.J. (1991) Editor's note: Priorities for the field of psychiatry. Yale Psychiatry 1(1):2. 3. Nestler, E.J. (1991) Response to letter to the Editor. Academic Psychiatry 15:174-175. 4. Nestler, E.J. (1992) Editor's note: The proper use of psychiatric medications. Yale Psychiatry 1(2):2. 5. Nestler, E.J. (1992) Editor's note: Psychiatry residency training. Yale Psychiatry 2(1):2. 6. Nestler, E.J. (1993) Editor's note: "To pay or not to pay." Yale Psychiatry 2(2):2-3. 7. Nestler, E.J. (1993) Editor's note: Molecular Psychiatry. Yale Psychiatry 3(1):2.

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8. Nestler, E.J. (1994) Editor's note: Side Effects of Psychotherapy. Yale Psychiatry 3(2):2. 9. Nestler, E.J. (1994) A shot in the arm for addiction [Review of ADDICTION: From Biology to Drug Policy, by A. Goldstein, W.H. Freeman, 1993]. Cell 77:179-180. 10. Nestler, E.J. (1994) Editor’s note: The Promise of Drug Abuse Research. Yale Psychiatry 4(1):2. 11. Nestler, E.J. (1995) Review of Schizophrenia: From Mind to Molecule, ed. by N.C. Andreasen (American Psychiatric Press), J. Nerv. Mental Dis. 183:117-118. 12. Nestler, E.J. (1995) Editor’s note: Window on the Brain. Yale Psychiatry 4(2):2-3. 13. Nestler, E.J. (1995) Editor’s note: Psychiatry in the Next Century. Yale Psychiatry 5(1):2. 14. Nestler, E.J. (1996) Editor’s note: Psychiatric neuroscience. Yale Psychiatry 5(2):2. 15. Nestler, E.J. (1996) Editor’s note: Residencies past and future. Yale Psychiatry 6(1):2-3. 16. Duman, R.S. and Nestler, E.J. (1997) Images in Neuroscience: Tracking DNA: The Southern blot. Am. J. Psychiatry 154:3. 17. Nestler, E.J. (1997) Images in Neuroscience: Identifying DNA transcription factors. Am. J. Psychiatry 154:146. 18. Nestler, E.J. (1997) An emerging pathophysiology of schizophrenia? (News and Views). Nature 385:578-579. 19. Hyman, S.E. and Nestler, E.J. (1997) Reply to Letter to the Editor. Am. J. Psychiatry 154:440-441. 20. Nestler, E.J., Gao, X.-M., and Tamminga, C.A. (1997) Images in Neuroscience: Immediate early genes. Am. J. Psychiatry 154:312. 21. Malison, R.T., Price, L.H., Nestler, E.J., Heninger, G.R., and Duman, R.S. (1996) Letter: Efficacy of papaverine addition in treatment-refractory major depression. Am. J. Psychiatry 154:579-580. 22. Nestler, E.J. (1997) The two Georges: A tribute to George Aghajanian and George Heninger. Yale Psychiatry 6(2):5-8. 23. Nestler, E.J. (1997) Toward an “ACMP”, American College of Molecular Psychiatry. In: ACNP: First 25 Years, JM Productions, Brentwood, TN, pp. 119-122. 24. Nestler, E.J. (1997) Editor’s note: Looking back on the first six years of Yale Psychiatry. Yale Psychiatry 7(1):2-3. 25. Nestler, E.J. (1998) Not so special K’s: Let’s limit K05 awards. Arch. Gen. Psychiatry 55:15-16. 26. Nestler, E.J. (1998) A molecular mechanism for addiction: cAMP systems, In: Basic Neurochemistry, 6th ed., ed. by G.J. Siegel, B.W. Agranoff, R.W. Alberts, S.K. Fisher, and M.D. Uhler, Lippincott-Raven Publishers. 27. Nestler, E.J. (1998) The neurobiology of drug addiction: Implications for severe mental illnesses. Decade of the Brain (NAMI Publication) 9(2):1-3. 28. Charney, D.S., Innis, R.B., Nestler, E.J., Davis, K.L., Nemeroff, C.B., and Weinberger, D.R. (1999) Increasing public trust and confidence in psychiatric research. Biol. Psychiatry 46:1-2. 29. Charney, D.S., Innis, R.B., Nestler, E.J., Davis, K.L., Nemeroff, C.B., and Weinberger, D.R. (1999) The role of scientific journals in the advancement of ethical conduct in research. Biol. Psychiatry 46:1-2. 30. Charney, D.S., Innis, R.B., and Nestler, E.J. (1999) Informed consent and protection of subjects. Biol. Psychiatry 46:1007-1008.

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31. Charney, D.S., Innis, R.B., Nestler, E.J., and Manji, H. (2001) What’s new in Biological Psychiatry. Biol. Psychiatry 50:1-2. 32. Nestler, E.J. (2001) Genetic Basis of Addiction. Psychiatric Times 19(2):56-60. 33. Charney, D.S., Innis, R.B., Nestler, E.J., and Manji, H. (2003) New Initiatives in Biological Psychiatry. Biol. Psychiatry 53:1-2. 34. Carlezon, W.A. Jr. and Nestler, E.J. (2003) Response: What role do GluR1 subunits play in drug abuse? Trends Neurosci. 26:182-183. 35. Nestler, E.J. (2003) Reply: Animal Models of Mood disorders. Biol. Psychiatry 53:270. 36. Nestler, E.J. (2003) Obituary for Patricia S. Goldman-Rakic (1937-2003). Nature 425:471. 37. Nestler, E.J., Tyler, D., LaGrone A. (2005) Parkland Psychiatry. Dallas Morning News, January 3, 2005, op-ed page. 38. Nestler, E.J. (2005) Commentary: Neurobiology and molecular biology. In: Psychiatry, Psychoanalysis, and the New Biology of Mind, by E.R. Kandel, American Psychiatric Press, Washington, D.C., p. 157-159. 39. Charney, D.S., Berrettini, W., Biederman, J., Innis, R.B., Nestler, E.J., and Rush, A.J. (2005) Maintaining a steady cours. One of the "hottest journals of the millennium...". Biol. Psychiatry 58:433-434. 40. Tamminga, C.A. and Nestler, E.J. (2005) Editorial: Pathological gambling: Focusing on the addiction, not the activity. Am. J. Psychiatry 163:180-181. 41. Berton, O., Krishnan, V., and Nestler, E.J. (2006) Response to letter to the Editor. Science 312:1598-1599. 42. Nestler, E.J. (2006) Special issue on animal models of mood and psychotic disorders. Biol. Psychiatry 59:1103. 43. Nestler, E.J. (2008) Journal Club: A psychiatrist talks about finding answers that add up across all levels. Nature 451:1033. 44. Krystal, J.H. et al. (the Biological Psychiatry editorial board) (2008) It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol. Psychiatry 63:725-727. 45. Krishnan, V., Berton, O., and Nestler, E.J. (2008) The use of animal models in psychiatric research and treatment. Am. J. Psychiatry 165:1109. 46. Nestler, E.J. (2009) Epigenetic mechanisms in psychiatry. Biol. Psychiatry 65:189-190. 47. Nestler, E.J. (2009) Drug abuse, addiction and the developing brain: Foreword. Dev. Neurosci. 31:6. 48. Nestler, E.J. and Krystal, J.H. (2012) Planning the new National Institute on Substance Use and Addiction Disorders. Biol. Psychiatry 72:166-167. 49. Nestler, E.J. (2012) Stress makes its mark. Nature 490:171-172. 50. Akbarian, S. and Nestler, E.J. (2013) Epigenetic mechanisms in psychiatry. Neuropsychopharmacology 38:1-2. 51. Nestler, E.J. and Greengard, P. (2013) A conversation with Paul Greengard. Annu. Rev. Pharmacol. Toxicol. 53:1-16. https://www.youtube.com/watch?v=HkZTkk_wDzk 52. Nestler, E.J. (2013) The origins of molecular psychiatry. J. Mol. Psychiatry 1:3. 53. Nestler, E.J. (2013) Epigenetic inheritance: Fact or fiction. Dana Alliance website, April 2013, http://www.dana.org/news/reportonprogress/.

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54. Geschwind, D. and Nestler, E.J. (2014) Neurodegenerative dementias: connecting psychiatry and neurology through a shared neurobiology. Biol. Psychiatry 75:518-519. Abstracts: not listed