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Michelle A.Borres BSMT 1-C ELECOXIB

BRAND NAME: Celebrex

IDENTIFICATION OF SUBSTANCE:

Trade name: CelecoxibProduct Number: C-1502

Manufacturer/Supplier: LC Laboratories165 New Boston StreetWoburn, MA 01801 USA

COMPOSITION DATA ON COMPONENTS:

Chemical Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl] benzenesulfonamideSynonyms: Celebrex, Celebra, Celecox, Onsenal, Solexa, SC-58635, YM-177CAS Registry Number: 169590-42-5Molecular Weight: 381.37

Molecular Formula: C17H14F3N3O2S

STRUCTURAL FORMULA:

PHYSICAL AND CHEMICAL PROPERTIES: Form: solid powderColor: whiteOdor: none

http://www.lclabs.com/PRODFILE/A-C/C-1502.php4http://www.lclabs.com/PRODFILE/A-C/C-1502.php4http://www.lclabs.com/PRODFILE/A-C/C-1502.php4

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DISADVANTAGES

If too much , can cause common adverse effects like, headache, abdominalpain, dyspepsia, diarrhea, nausea, flatulence, and insomnia.

Other side effects include fainting, kidney failure, heart failure, aggravation of hypertension, chest pain, ringing in the ears, deafness, stomach and intestinalulcers, bleeding, blurred vision, anxiety, photosensitivity, weight gain, waterretention, flu-like symptoms, drowsiness and weakness.

Should not be used if youre pregnant or having breastfeeding.

HOW CELEBREX WORKSThe human body contains many enzymes that facilitate chemical reactions in the body.

One of these enzymes is Cyclooxygenase-2 (COX-2), which is involved in causinginflammation and pain in parts of the body where there is arthritis or injury.

CELEBREX at recommended doses selectively inhibits COX-2, which helps relievearthritis pain and inflammation as well as acute pain in adults.

http://www.medicinenet.com/headache/article.htmhttp://www.medicinenet.com/headache/article.htmhttp://www.medicinenet.com/abdominal_pain_causes_remedies_treatment/article.htmhttp://www.medicinenet.com/abdominal_pain_causes_remedies_treatment/article.htmhttp://www.medicinenet.com/dyspepsia/symptoms.htmhttp://www.medicinenet.com/diarrhea/article.htmhttp://www.medicinenet.com/nausea/symptoms.htmhttp://www.medicinenet.com/intestinal_gas_belching_bloating_flatulence/article.htmhttp://www.medicinenet.com/insomnia/article.htmhttp://www.medicinenet.com/fainting/article.htmhttp://www.medicinenet.com/fainting/article.htmhttp://www.medicinenet.com/kidney_failure/article.htmhttp://www.medicinenet.com/heart_failure/article.htmhttp://www.onhealth.com/high_blood_pressure/article.htmhttp://www.medicinenet.com/chest_pain/symptoms.htmhttp://www.medicinenet.com/tinnitus_ringing_in_the_ears/article.htmhttp://www.medicinenet.com/hearing_loss/symptoms.htmhttp://www.medicinenet.com/anxiety/article.htmhttp://www.medicinenet.com/sun-sensitive_drugs_photosensitivity_to_drugs/article.htmhttp://www.medicinenet.com/weight_gain/symptoms.htmhttp://www.medicinenet.com/weakness/symptoms.htmhttp://www.medicinenet.com/weakness/symptoms.htmhttp://www.medicinenet.com/weight_gain/symptoms.htmhttp://www.medicinenet.com/sun-sensitive_drugs_photosensitivity_to_drugs/article.htmhttp://www.medicinenet.com/anxiety/article.htmhttp://www.medicinenet.com/hearing_loss/symptoms.htmhttp://www.medicinenet.com/tinnitus_ringing_in_the_ears/article.htmhttp://www.medicinenet.com/chest_pain/symptoms.htmhttp://www.onhealth.com/high_blood_pressure/article.htmhttp://www.medicinenet.com/heart_failure/article.htmhttp://www.medicinenet.com/kidney_failure/article.htmhttp://www.medicinenet.com/fainting/article.htmhttp://www.medicinenet.com/insomnia/article.htmhttp://www.medicinenet.com/intestinal_gas_belching_bloating_flatulence/article.htmhttp://www.medicinenet.com/nausea/symptoms.htmhttp://www.medicinenet.com/diarrhea/article.htmhttp://www.medicinenet.com/dyspepsia/symptoms.htmhttp://www.medicinenet.com/abdominal_pain_causes_remedies_treatment/article.htmhttp://www.medicinenet.com/abdominal_pain_causes_remedies_treatment/article.htmhttp://www.medicinenet.com/headache/article.htm

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HISTORY

Honorees Peter Isakson, Ph.D., Jamie Masferrer, Ph.D., Karen Seibert, Ph.D., and John Talley,Ph.D. of Pharmacia created the molecule Celecoxib , the basis for the medicine Celebrex,

which blocks the inflammation-triggering action of the COX-2 enzyme, bringing relief to millions

of people around the world who suffer from osteoarthritis, rheumatoid arthritis, and pain.

Dr. John Talley and his team of medicinal chemists manipulated molecules and made thousands

of different analogs. They finally found a compound that was a strong selective inhibitor of

COX-2, but it had a long half-life - it lingered in the body too long. The molecule was sent back

to the laboratory and modified, and the scientists synthesized the compound that eventually

became Celebrex.

Clinical trials of Celebrex began in 1995 . In all, some 13,000 volunteers in countries all over the world

took part in the trials. In June 1998 , the company submitted an application to the Food and Drug

Administration (FDA) to market the drug. The FDA gave the application an accelerated review, and on

December 30, 1998, Celebrex (100mg and 200mg) was approved for the treatment of osteoarthritis and

rheumatoid arthritis . August 29, 2002 for 400mg Celebrex and December 15, 2006 for 50mg . It has alsobeen approved for familial adenomatous polyposis, a rare and devastating disease that often leads to

colon cancer.

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INDICATIONS AND USAGE

CELEBREX is indicated:

1) For relief of the signs and symptoms of osteoarthritis.

2) For relief of the signs and symptoms of rheumatoid arthritis in adults.

3) For the management of acute pain in adults .

4) For the treatment of primary dysmenorrhea.

5) To reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis

(FAP), as an adjunct to usual care (e.g., endoscopic surveillance, surgery). The efficacy and safety

of CELEBREX treatment in patients with FAP beyond six months have not been studied.

CONTRAINDICATIONS

1) CELEBREX is contraindicated in patients with known hypersensitivity to celecoxib.

2) CELEBREX should not be given to patients who have demonstrated allergic-type reactions to

sulfonamides.

3) CELEBREX should not be given to patients who have experienced asthma, urticaria, or allergic-

type reactions after taking aspirin or other NSAIDs.

SOURCES:http://www.medicinenet.com/celecoxib/article.htm

http://www.drugs.com/celebrex.html

http://www.celebrex.com/about-celebrex.aspx

MY VIDEO: http://www.youtube.com/watch?v=53FKGMPEAdU

http://www.medicinenet.com/celecoxib/article.htmhttp://www.drugs.com/celebrex.htmlhttp://www.celebrex.com/about-celebrex.aspxhttp://www.youtube.com/watch?v=53FKGMPEAdUhttp://www.youtube.com/watch?v=53FKGMPEAdUhttp://www.youtube.com/watch?v=53FKGMPEAdUhttp://www.youtube.com/watch?v=53FKGMPEAdUhttp://www.celebrex.com/about-celebrex.aspxhttp://www.drugs.com/celebrex.htmlhttp://www.medicinenet.com/celecoxib/article.htm

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Cebu Doctors University North Reclamation Area, Mandaue City

GGG RRR OOO UUU PPP 222 MMM EEE MMM BBB EEE RRRSSS :::

Claire Cabillada

Michelle Borres

Bon Paul Baron

Amalia Cajes

Christian Klein Calvo

Esther Son

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