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PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

fit/v 9, 1 996

Volumne 93 / Numnber 14



PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Officers of the Academy

BRUCE ALBERTS, President JACK HALPERN, Vice President PETER H. RAVEN, Home Secretary F. SHERWOOD ROWLAND, Foreign Secretar-y RONALD L. GRAHAM, Treasurer

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PETER J. BICKEL MICHAEL T. CLEGG MARSHALL H. COHEN STANLEY N. COHEN MAX D. COOPER JAMES E. DARNELL, JR. IGOR B. DAWID HERMAN N. EISEN RAYMOND L. ERIKSON RONALD M. EVANS NINA FEDOROFF CHARLES FEFFERMAN JOSEPH L. GOLDSTEIN

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PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

July 9, 1996 Volume 93, Number 14 pp. 6847-7426

Table of Contents* INFORMATION FOR CONTRIBUTORS 1-11

AUTHOR INDEX ix-xi

POSITIONS AVAILABLE xii

Commentary Chromosome manipulation: A systematic approach 6847-6850 toward understanding human chromosome structure and function

Huntington F. Willard

Inaugural Articles Hypothalamic integration of body fluid regulation 7397-7404

D. A. Denton, M. J. McKinley, and R. S. Weisinger

Self-recognition and abstraction abilities in the 7405-7408 common chimpanzee studied with distorting mirrors

Ann Kitchen, Derek Denton, and Linda Brent

Physical Sciences CHEMISTRY

Probing the oligomeric structure of an enzyme 6851-6856 by electrospray ionization time-of-flight mass spectrometry

Michael C. Fitzgerald, Igor Chernushevich, Kenneth G. Standing, Christian P. Whitman, and Stephen B. H. Kent

*Editor's Note: Beginning with this issue, articles are grouped according to the Table of Contents' classifications, rather than by the date of receipt offinal edited manuscript.

Natural abundance solid-state carbon NMR studies of 6857-6860 photosynthetic reaction centers with photoinduced polarization

Martin G. Zysmilich and Ann McDermott

PHYSICS

Excitation transfer spectroscopy with two metastable 6861-6862 138Ba+ ions in same trap

Hans Dehmelt, Xinxin Zhao, Nan Yu, and Warren Nagourney

Biological Sciences

APPLIED BIOLOGICAL SCIENCES

Differential display of intestinal mRNAs regulated 6863-6868 by dietary zinc

Raymond K. Blanchard and Robert J. Cousins

BIOCHEMISTRY

Ferulate-5-hydroxylase from Arabidopsis thaliana 6869-6874 defines a new family of cytochrome P450-dependent monooxygenases

Knut Meyer, Joanne C. Cusumano, Chris Somerville, and Clint C. S. Chapple

iii



Contents

Molecular mechanics calculations of the riboacetal 6875-6880 internucleotide linkage in double and triple helices

Rhonda A. Torres, Orn Almarsson, and Thomas C. Bruice

High mobility group I(Y)-like DNA-binding domains 6881-6885 on a bacterial transcription factor

Francisco J. Nicolas, Maria L. Cayuela, Isabel M. Martfnez-Argudo, Rosa M. Ruiz-Vazquez, and Francisco J. Murillo

Conservation and diversification in homeodomain-DNA 6886-6891 interactions: A comparative genetic analysis

David S. Wilson, Guojun Sheng, Susie Jun, and Claude Desplan

Mutational analysis of NM23-H2/NDP kinase 6892-6897 identifies the structural domains critical to recognition of a c-myc regulatory element

Edith H. Postel, Valerie H. Weiss, Jutta Beneken, and Ajay Kirtane

The stress response to ionizing radiation involves 6898-6901 c-Abl-dependent phosphorylation of SHPTP1

Surender Kharbanda, Ajit Bharti, Dehua Pei, Jun Wang, Pramod Pandey, Ruibao Ren, Ralph Weichselbaum, Christopher T. Walsh, and Donald Kufe

Crystal structure of the catalytic domain of 6902-6906 Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: Implications for the activation process and for ADP ribosylation

Mi Li, Fred Dyda, Itai Benhar, Ira Pastan, and David R. Davies

Mutational analysis and molecular modeling of the 6907-6912 nonapeptide hormone binding domains of the [Arg8]vasotocin receptor

Holger Hausmann, Anke Richters, Hans-Jurgen Kreienkamp, Wolfgang Meyerhof, Henri Mattes, Karl Lederis, Henk Zwiers, and Dietmar Richter

The structure of bovine F1-ATPase complexed with 6913-6917 the antibiotic inhibitor aurovertin B

Mark J. van Raaij, Jan Pieter Abrahams, Andrew G. W. Leslie, and John E. Walker

Evidence for a novel DNA damage binding protein in 6918-6923 human cells

Rita Ghosh, Chuan-Hsien Peng, and David L. Mitchell

Activation of the Raf-1/MAP kinase cascade is not 6924-6928 sufficient for Ras transformation of RIE-1 epithelial cells

Sean M. Oldham, Geoffrey J. Clark, Lisa M. Gangarosa, Robert J. Coffey, Jr., and Channing J. Der

ATP-dependent uptake of natural product cytotoxic 6929-6934 drugs by membrane vesicles establishes MRP as a broad specificity transporter

Saptarshi Paul, Lisa M. Breuninger, Kenneth D. Tew, Hongxie Shen, and Gary D. Kruh

Increased accommodation of nascent RNA in a 6935-6940 product site on RNA polymerase II during arrest

Weigang Gu, Megan Wind, and Daniel Reines

Lack of the DNA repair protein 06-methylguanine- 6941-6946 DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors

John R. Silber, A. Blank, Michael S. Bobola, Beth A. Mueller, Douglas D. Kolstoe, George A. Ojemann, and Mitchel S. Berger

BCL-6, a POZ/zinc-finger protein, is a 6947-6952 sequence-specific transcriptional repressor

Chih-Chao Chang, Bihui H. Ye, R. S. K. Chaganti, and Riccardo Dalla-Favera

Interactions between tRNA identity nucleotides and 6953-6958 their recognition sites in glutaminyl-tRNA synthetase determine the cognate amino acid affinity of the enzyme

Michael Ibba, Kwang-Won Hong, Joyce M. Sherman, Sanja Sever, and Dieter Soll

Ceramide-binding and activation defines protein 6959-6963 kinase c-Raf as a ceramide-activated protein kinase

Andrea Huwiler, Josef Brunner, Richard Hummel, Margriet Vervoordeldonk, Silvia Stabel, Henk van den Bosch, and Josef Pfeilschifter

Molecular characterization of a FKBP-type 6964-6969 immunophilin from higher plants

Sheng Luan, Jorg Kudla, Wilhelm Gruissem, and Stuart L. Schreiber

Linker histones affect patterns of digestion of 6970-6974 supercoiled plasmids by single-strand-specific nucleases

Maria Ivanchenko, Jordanka Zlatanova, Patrick Varga-Weisz, Ahmed Hassan, and Kensal van Holde

The C-terminal domain of the largest subunit of RNA 6975-6980 polymerase II interacts with a novel set of serine/arginine-rich proteins

Anton Yuryev, Meera Patturajan, Ying Litingtung, Ravi V. Joshi, Cristl Gentile, Maha Gebara, and Jeffry L. Corden

Binding site size limit of the 2:1 pyrrole-imidazole 6981-6985 polyamide-DNA motif

James J. Kelly, Eldon E. Baird, and Peter B. Dervan

A mechanism for inducing plant development: The 6986-6991 genesis of a specific inhibitor

Christopher E. Smith, Thomas Ruttledge, Zhaoxian Zeng, Ronan C. O'Malley, and David G. Lynn

Processing of the leader mRNA plays a major role in 6992-6997 the induction of thrS expression following threonine starvation in Bacillus subtilis

Ciaran Condon, Harald Putzer, and Marianne Grunberg-Manago

Kinetics of photo-induced electron transfer from 6998-7002 high-potential iron-sulfur protein to the photosynthetic reaction center of the purple phototroph Rhodoferax fermentans

A. Hochkoeppler, D. Zannoni, S. Ciurli, T. B. Meyer, M. A. Cusanovich, and G. Tollin

Ice as a matrix for IR-matrix-assisted laser desorption/ 7003-7007 ionization: Mass spectra from a protein single crystal

Stefan Berkenkamp, Michael Karas, and Franz Hillenkamp

iv



Contents

BIOPHYSICS

Natural abundance solid-state carbon NMR studies of 6857-6860 photosynthetic reaction centers with photoinduced polarization

Martin G. Zysmilich and Ann McDermott

Structure of the ripple phase in lecithin bilayers 7008-7012 W.-J. Sun, S. Tristram-Nagle, R. M. Suter, and J. F. Nagle

X-ray structure determination of a metastable state of 7013-7016 carbonmonoxy myoglobin after photodissociation

H. Hartmann, S. Zinser, P. Komninos, R. T. Schneider, G. U. Nienhaus, and F. Parak

Three quaternary structures for a single protein 7017-7021 De-Bin Huang, Clint F. Ainsworth, Fred J. Stevens, and Marianne Schiffer

Direct measurement of oligonucleotide binding 7022-7027 stoichiometry of gene V protein by mass spectrometry

Xueheng Cheng, Amy C. Harms, Paul N. Goudreau, Thomas C. Terwilliger, and Richard D. Smith

The N-terminal domain of Escherichia coli enzyme I 7028-7031 of the phosphoenolpyruvate/glycose phosphotransferase system: Molecular cloning and characterization

Francoise Chauvin, Alexey Fomenkov, Craig R. Johnson, and Saul Roseman

CELL BIOLOGY

The Mos/mitogen-activated protein kinase (MAPK) 7032-7035 pathway regulates the size and degradation of the first polar body in maturing mouse oocytes

Taesaeng Choi, Kenji Fukasawa, Renping Zhou, Lino Tessarollo, Kristina Borror, James Resau, and George F. Vande Woude

The glucose sensor protein glucokinase is expressed in 7036-7041 glucagon-producing ar-cells

Harry Heimberg, Anick De Vos, Karen Moens, Erik Quartier, Luc Bouwens, Danny Pipeleers, Emile Van Schaftingen, Ole Madsen, and Frans Schuit

bcl-2 overexpression reduces apoptotic photoreceptor 7042-7047 cell death in three different retinal degenerations

Jeannie Chen, John G. Flannery, Matthew M. LaVail, Roy H. Steinberg, Jun Xu, and Melvin I. Simon

Rfc5, a small subunit of replication factor C complex, 7048-7052 couples DNA replication and mitosis in budding yeast

Katsunori Sugimoto, Toshiyasu Shimomura, Keiji Hashimoto, Hiroyuki Araki, Akio Sugino, and Kunihiro Matsumoto

Brush border myosin-I truncated in the motor domain 7053-7058 impairs the distribution and the function of endocytic compartments in an hepatoma cell line

A. Durrbach, K. Collins, P. Matsudaira, D. Louvard, and E. Coudrier

Nuclear protein import: Ran-GTP dissociates the 7059-7062 karyopherin a43 heterodimer by displacing o from an overlapping binding site on ,B

Junona Moroianu, Gunter Blobel, and Aurelian Radu

Bcl-2 interacting protein, BAG-1, binds to and 7063-7068 activates the kinase Raf-I

Hong-Gang Wang, Shinichi Takayama, Ulf R. Rapp, and John C. Reed

Matrix metalloproteinase 2 releases active soluble 7069-7074 ectodomain of fibroblast growth factor receptor I

Ehud Levi, Rafael Fridman, Hua-Quan Miao, Yong-Sheng Ma, Avner Yayon, and Israel Vlodavsky

Hypoxia enhances stimulus-dependent induction of 7075-7080 E-selectin on aortic endothelial cells

Gregor Zund, David P. Nelson, Ellis J. Neufeld, Andrea L. Dzus, Joyce Bischoff, John E. Mayer, and Sean P. Colgan

17p (p53) allelic losses, 4N (G2/tetraploid) 7081-7084 populations, and progression to aneuploidy in Barrett's esophagus

Patricia C. Galipeau, David S. Cowan, Carissa A. Sanchez, Michael T. Barrett, Mary J. Emond, Douglas S. Levine, Peter S. Rabinovitch, and Brian J. Reid

EVOLUTION

Bootstrap confidence levels for phylogenetic trees 7085-7090 Bradley Efron, Elizabeth Halloran, and Susan Holmes

Does behavior reflect phylogeny in swiftlets (Aves: 7091-7096 Apodidae)? A test using cytochrome b mitochondrial DNA sequences

Patricia L. M. Lee, Dale H. Clayton, Richard Griffiths, and Roderic D. M. Page

Naturally occurring variation in copia expression is 7097-7102 due to both element (cis) and host (trans) regulatory variation

Lilya V. Matyunina, I. King Jordan, and John F. McDonald

Evolutionary changes in the expression pattern of a 7103-7107 developmentally essential gene in three Drosophila species

Degui Wang, J. Lawrence Marsh, and Francisco J. Ayala

GENETICS

Selection for genes encoding secreted proteins 7108-7113 and receptors

Robert D. Klein, Qimin Gu, Audrey Goddard, and Arnon Rosenthal

A change of ploidy can modify epigenetic silencing 7114-7119 Ortrun Mittelsten Scheid, Ludmila Jakovleva, Karin Afsar, Jolanta Maluszynska, and Jerzy Paszkowski

v



Contents

Stabilization of diverged tandem repeats by mismatch 7120-7124 repair: Evidence for deletion formation via a misaligned replication intermediate

Susan T. Lovett and Vladimir V. Feschenko

Mini-chromosomes derived from the human Y 7125-7130 chromosome by telomere directed chromosome breakage

R. Heller, K. E. Brown, C. Burgtorf, and W. R. A. Brown

Double-strand break repair in the absence of RAD51 7131-7136 in yeast: A possible role for break- induced DNA replication

Anna Malkova, Evgeny L. Ivanov, and James E. Haber

CHD1 is concentrated in interbands and puffed 7137-7142 regions of Drosophila polytene chromosomes

David G. Stokes, Kenneth D. Tartof, and Robert P. Perry

ECA39, a conserved gene regulated by c-Myc in mice, 7143-7148 is involved in G1/S cell cycle regulation in yeast

Oren Schuldiner, Amir Eden, Tamar Ben-Yosef, Ofra Yanuka, Giora Simchen, and Nissim Benvenisty

The activation of human gene MAGE-1 in tumor cells 7149-7153 is correlated with genome-wide demethylation

Charles De Smet, Olivier De Backer, Isabella Faraoni, Christophe Lurquin, Francis Brasseur, and Thierry Boon

Apolipoprotein B RNA editing enzyme-deficient 7154-7159 mice are viable despite alterations in lipoprotein metabolism

John R. Morrison, Chris Paszty, Mary E. Stevens, Steven D. Hughes, Trudy Forte, James Scott, and Edward M. Rubin

Stepwise assembly of the lipid-linked oligosaccharide 7160-7165 in the endoplasmic reticulum of Saccharomyces cerevisiae: Identification of the ALG9 gene encoding a putative mannosyl transferase

Patricie Burda, Stephan te Heesen, Arndt Brachat, Achim Wach, Andreas D'usterhoft, and Markus Aebi

Heterodimer formation and activity in the human 7166-7171 enzyme galactose-1-phosphate uridylyltransferase

J. P. Elsevier, L. Wells, B. B. Quimby, and J. L. Fridovich-Keil

IMMUNOLOGY

Interleukin 7 receptor-deficient mice lack -y5 T cells 7172-7177 Kazushige Maki, Shinji Sunaga, Yoshinori Komagata, Yuzo Kodaira, Ayako Mabuchi, Hajime Karasuyama, Kozo Yokomuro, Jun-ichi Miyazaki, and Koichi Ikuta

Direct binding of a soluble natural killer cell 7178-7183 inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule

Qing R. Fan, David N. Garboczi, Christine C. Winter, Nicolai Wagtmann, Eric 0. Long, and Don C. Wiley

Covalent assembly of a soluble T cell 7184-7189 receptor-peptide-major histocompatibility class I complex

Claude Gregoire, Shih-Yao Lin, Gilbert Mazza, Najet Rebai, Immanuel F. Luescher, and Bernard Malissen

Reduction in the level of Gal(ol,3)Gal in transgenic 7190-7195 mice and pigs by the expression of an oz(1,2)fucosyltransferase

Ajay Sharma, Jeannine Okabe, Patrick Birch, Steven B. McClellan, Michael J. Martin, Jeffery L. Platt, and John S. Logan

Treatment of experimental autoimmune 7196-7201 encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit

Jia-Bin Sun, Carola Rask, Tomas Olsson, Jan Holmgren, and Cecil Czerkinsky

Critical contribution of ,B chain residue 57 in peptide 7202-7206 binding ability of both HLA-DR and -DQ molecules

Barbara S. Nepom, Gerald T. Nepom, Marilyn Coleman, and William W. Kwok

Cellular mechanisms for the formation of a soluble 7207-7212 form derivative of T-cell receptor o chain by suppressor T cells

Yasuyuki Ishii, Tatsumi Nakano, and Kimishige Ishizaka

DNA vaccine for hepatitis B: Evidence for 7213-7218 immunogenicity in chimpanzees and comparison with other vaccines

Heather L. Davis, Michael J. McCluskie, John L. Gerin, and Robert H. Purcell

MEDICAL SCIENCES

Ul small nuclear RNA chimeric ribozymes with 7219-7224 substrate specificity for the Rev pre-mRNA of human immunodeficiency virus

Alessandro Michienzi, Silvia Prislei, and Irene Bozzoni

Correction of diabetic alterations by glucokinase 7225-7230 Tura Ferre, Anna Pujol, Efren Riu, Fatima Bosch, and Alfons Valera

Mass vaccination to control chickenpox: The influence 7231-7235 of zoster

Neil M. Ferguson, Roy M. Anderson, and Geoff P. Garnett

Increased liposome extravasation in selected tissues: 7236-7241 Effect of substance P

Joseph Rosenecker, Weiming Zhang, Keelung Hong, James Lausier, Pierangelo Geppetti, Shigemi Yoshihara, Demetrios Papahadjopoulos, and Jay A. Nadel

Suppression of diet-induced atherosclerosis in low 7242-7246 density lipoprotein receptor knockout mice overexpressing lipoprotein lipase

Masako Shimada, Shun Ishibashi, Toshimori Inaba, Hiroaki Yagyu, Kenji Harada, Jun-ichi Osuga, Ken Ohashi, Yoshio Yazaki, and Nobuhiro Yamada

vi



Contents

Viral dynamics in vivo: Limitations on estimates of 7247-7251 intracellular delay and virus decay

Andreas V. M. Herz, Sebastian Bonhoeffer, Roy M. Anderson, Robert M. May, and Martin A. Nowak

Surface-epitope masking and expression cloning 7252-7257 identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family

Zao-zhong Su, Jian Lin, Ruoqian Shen, Peter E. Fisher, Neil I. Goldstein, and Paul B. Fisher

Cloning and expression of human deoxyguanosine 7258-7262 kinase cDNA

Magnus Johansson and Anna Karlsson

Antisense RNA to the type I insulin-like growth 7263-7268 factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo

Peter Burfeind, Cheryl L. Chernicky, Frauke Rininsland, Joseph Ilan, and Judith Ilan

Cytotoxic analogs of luteinizing hormone-releasing 7269-7273 hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent

Attila Nagy, Andrew V. Schally, Patricia Armatis, Karoly Szepeshazi, Gabor Halmos, Magdolna Kovacs, Marta Zarandi, Kate Groot, Masahiro Miyazaki, Andreas Jungwirth, and Judit Horvath

Costimulatory protein B7-1 enhances the cytotoxic 7274-7278 T cell response and antibody response to hepatitis B surface antigen

Xiao-Song He, Huo-Sheng Chen, Keting Chu, Marianne Rivkina, and William S. Robinson

Circumventing tolerance to generate autologous 7279-7282 monoclonal antibodies to the prion protein

R. Anthony Williamson, David Peretz, Nechama Smorodinsky, Raiza Bastidas, Hana Serban, Ingrid Mehlhorn, Stephen J. DeArmond, Stanley B. Prusiner, and Dennis R. Burton

Spontaneous diabetes mellitus in transgenic mice 7283-7288 expressing human islet amyloid polypeptide

Juliette Janson, Walter C. Soeller, Patrick C. Roche, Robin T. Nelson, Anthony J. Torchia, David K. Kreutter, and Peter C. Butler

Characterization of promoters and stable transfection 7289-7294 by homologous and nonhomologous recombination in Plasmodium falciparum

Brendan S. Crabb and Alan F. Cowman

Mechanism of anti-HIV action of masked alaninyl 7295-7299 d4T-MP derivatives

J. Balzarini, A. Karlsson, S. Aquaro, C.-F. Perno, D. Cahard, L. Naesens, E. De Clercq, and C. McGuigan

Molecular cloning of a rat chromosome putative 7300-7304 recombinogenic sequence homologous to the hepatitis B virus encapsidation signal

Hiroshi Aoki, Kazunori Kajino, Yasuyuki Arakawa, and Okio Hino

Formation of stable cationic lipid/DNA complexes for 7305-7309 gene transfer

Hans E. J. Hofland, Lee Shephard, and Sean M. Sullivan

MICROBIOLOGY

Highly stable expression of a foreign gene from 7310-7314 rabies virus vectors

Teshome Mebatsion, Matthias J. Schnell, James H. Cox, Stefan Finke, and Karl-Klaus Conzelmann

A chromosomal locus required for copper resistance, 7315-7320 competitive fitness, and cytochrome c biogenesis in Pseudomonas fluorescens

Ching-Hong Yang, Hamid R. Azad, and Donald A. Cooksey

A family of lysozyme-like virulence factors in bacterial 7321-7326 pathogens of plants and animals

Arcady R. Mushegian, Karla Jean Fullner, Eugene V. Koonin, and Eugene W. Nester

Dimorphism and haploid fruiting in Cryptococcus 7327-7331 neoformans: Association with the ar-mating type

Brian L. Wickes, Maria E. Mayorga, Ursula Edman, and Jeffrey C. Edman

NEUROBIOLOGY

Localization of alpha type II calcium 7332-7336 calmodulin-dependent protein kinase at glutamatergic but not -y-aminobutyric acid (GABAergic) synapses in thalamus and cerebral cortex

Xiao-Bo Liu and Edward G. Jones

Selective expression of m2 muscarinic receptor in the 7337-7340 parvocellular channel of the primate visual cortex

Ladislav Mrzljak, Allan I. Levey, and Pasko Rakic

Genetic construction and properties of a diphtheria 7341-7345 toxin-related substance P fusion protein: In vitro destruction of cells bearing substance P receptors

Caroline E. Fisher, Jay A. Sutherland, James E. Krause, John R. Murphy, Susan E. Leeman, and Johanna C. vanderSpek

Ciliary neurotrophic factor protects striatal output 7346-7351 neurons in an animal model of Huntington disease

Keith D. Anderson, Nikos Panayotatos, Thomas L. Corcoran, Ronald M. Lindsay, and Stanley J. Wiegand

Detection of JC virus DNA sequence and expression 7352-7357 of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma

Adrienne Rencic, Jennifer Gordon, Jessica Otte, Mark Curtis, Albert Kovatich, Philip Zoltick, Kamel Khalili, and David Andrews

Interocular transfer in perceptual learning of a 7358-7362 pop-out discrimination task

Aniek A. Schoups and Guy A. Orban

vii



Contents

Isoform-specific interaction of the af1A subunits of 7363-7368 brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25

Jens Rettig, Zu-Hang Sheng, D. Kyle Kim, Connie D. Hodson, Terry P. Snutch, and William A. Catterall

Alternative splicing of agrin regulates its binding to 7369-7374 heparin, o-dystroglycan, and the cell surface

John J. O'Toole, Katherine A. Deyst, Mark A. Bowe, Mary A. Nastuk, Beth A. McKechnie, and Justin R. Fallon

PHARMACOLOGY

Targeted disruption of the mouse ,B1-adrenergic 7375-7380 receptor gene: Developmental and cardiovascular effects

Daniel K. Rohrer, Kavin H. Desai, Jeffrey R. Jasper, Mary E. Stevens, Donald P. Regula, Jr., Gregory S. Barsh, Daniel Bernstein, and Brian K. Kobilka

High affinity type I interleukin 1 receptor antagonists 7381-7386 discovered by screening recombinant peptide libraries

Stephen D. Yanofsky, David N. Baldwin, John H. Butler, Frank R. Holden, Jeffrey W. Jacobs, Palaniappan Balasubramanian, Jason P. Chinn, Steven E. Cwirla, Elizabeth Peters-Bhatt, Erik A. Whitehorn, Emily H. Tate, Ann Akeson, Terry L. Bowlin, William J. Dower, and Ronald W. Barrett

PHYSIOLOGY

Creation of a reversible on/off system for site-specific 7387-7391 in vivo control of exogenous gene activity in the renal glomerulus

Masanori Kitamura

Adjacent pore-lining residues within sodium channels 7392-7396 identified by paired cysteine mutagenesis

Jean-Pierre Benitah, Gordon F. Tomaselli, and Eduardo Marban

Hypothalamic integration of body fluid regulation 7397-7404 D. A. Denton, M. J. McKinley, and R. S. Weisinger

Self-recognition and abstraction abilities in the 7405-7408 common chimpanzee studied with distorting mirrors

Ann Kitchen, Derek Denton, and Linda Brent

Structure of murine and human renal type II 7409-7414 Na+-phosphate cotransporter genes (Npt2 and NPT2)

C. M. Hartmann, A. S. Hewson, C. H. Kos, H. Hilfiker, Y. Soumounou, H. Murer, and H. S. Tenenhouse

PLANT BIOLOGY

Pollen specific expression of maize genes encoding 7415-7420 actin depolymerizing factor-like proteins

Imelda Lopez, Richard G. Anthony, Sutherland K. Maciver, Chang-Jie Jiang, Safina Khan, Alan G. Weeds, and Patrick J. Hussey

Social Sciences

PSYCHOLOGY

Psychophysical evidence for fast region-based 7421-7426 segmentation processes in motion and color

Per M0ller and Anya C. Hurlbert

viii



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