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Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 23 (Nov. 10, 1998), pp. i-x Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/46687 . Accessed: 05/05/2014 06:39 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 62.122.78.35 on Mon, 5 May 2014 06:39:15 AM All use subject to JSTOR Terms and Conditions
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Page 1: Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 95, No. 23 (Nov. 10, 1998), pp. i-xPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/46687 .

Accessed: 05/05/2014 06:39

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp

.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].

.

National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.

http://www.jstor.org

This content downloaded from 62.122.78.35 on Mon, 5 May 2014 06:39:15 AMAll use subject to JSTOR Terms and Conditions

Page 2: Front Matter

PROCEEDINGS

OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

November 1 , 1 998

Volume 95/ Number 23

INCLUDES: STANLEY B. PRUSINER'S NOBEL LECTURE ON PRIONS

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Page 3: Front Matter

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Page 4: Front Matter

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Page 5: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

Officers of the Academy

BRUCE ALBERTS, President JACK HALPERN, Vice President PETER H. RAVEN, Home Secretary F. SHERWOOD ROWLAND, Foreign Secretary RONALD L. GRAHAM, Treasurer

Editor-in-Chief NICHOLAS R. COZZARELLI

Editorial Board of the Proceedings

MAY R. BERENBAUM CHARLES FEFFERMAN PHIL W. MAJERUS CARLA J. SHATZ

PETER J. BICKEL WALTER M. FITCH PHILIPPA MARRACK KAI L. SIMONS

MARIO R. CAPECCHI JOSEPH L. GOLDSTEIN RICHARD D. MCKELVEY CHRISTOPHER A. SIMS

WILLIAM CATTERALL CAROL A. GROSS ARNO G. MOTULSKY SOLOMON H. SNYDER

ANTHONY CERAMI JACK HALPERN RONALD L. PHILLIPS CHRISTOPHER R. SOMERVILLE

PIERRE CHAMBON BERTIL HILLE THOMAS D. POLLARD LARRY R. SQUIRE

MARSHALL H. COHEN PIERRE C. HOHENBERG STANLEY B. PRUSINER STEVEN M. STANLEY

STANLEY N. COHEN H. ROBERT HORVITZ CHARLES RADDING CHARLES F. STEVENS

DAVID R. DAVIES ERICH P. IPPEN GIAN-CARLO ROTA FRANK H. STILLINGER

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RAYMOND L. ERIKSON ROGER KORNBERG PAUL R. SCHIMMEL DON C. WILEY

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NINA FEDOROFF HARVEY F. LODISH AARON J. SHATKIN

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES.

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Copyright: Volumes 90-95, copyright ? 1993-1998 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,

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Page 6: Front Matter

OF

PROCEED INGS

OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

November 10, 1998 Volume 95, Number 23 pp. 13349-13998

Table of Contents

Commentaries

Plant gene silencing regularized 13349-13351 George Bruening * See companion article on page 13959

Tuberculosis: Old problems and new approaches 13352-13354 Roy M. Anderson * See companion article on page 13881

DSHP: A "power bar" for sustained immune 13355-13357 responses?

Anne B. Satterthwaite, David J. Rawlings, and Owen N. Witte * See companion article on page 13765

Higher-plant phytochrome: "I used to date 13358-13360 histidine, but now I prefer serine"

Anthony R. Cashmore * See companion article on page 13976

Bone homeostasis 13361-13362 Gideon A. Rodan * See companion article on page 13835

Nobel Lecture

Prions 13363-13383 Stanley B. Prusiner

Physical Sciences

APPLIED MATHEMATICS

The thermal explosion revisited 13384-13386 G. I. Barenblatt, J. B. Bell, and W. Y. Crutchfield

CHEMISTRY

Polyazamacrolides from ladybird beetles: Ring-size 13387-13391 selective oligomerization

Frank C. Schroeder, Scott R. Smedley, Leah K. Gibbons, Jay J. Farmer, Athula B. Attygalle, Thomas Eisner, and Jerrold Meinwald

MATHEMATICS

On representations of finite type 13392-13396 Richard V. Kadison

Biological Sciences

APPLIED BIOLOGICAL SCIENCES

Synthesis of medium-chain-length 13397-13402 polyhydroxyalkanoates in Arabidopsis thaliana using intermediates of peroxisomal fatty acid /3-oxidation

Volker Mittendorf, Elizabeth J. Robertson, Rachel M. Leech, Niels Kruger, Alexander Steinbiichel, and Yves Poirier

iii

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Page 7: Front Matter

Contents

BIOCHEMISTRY

Identification of a structural determinant for 13403-1.3406 resistance to /3-lactam antibiotics in Gram-positive bacteria

N. Mouz, E. Gordon, A.-M. Di Guilmi, I. Petit, Y. P6tillot, Y. Dupont, R. Hakenbeck, T. Vernet, and 0. Dideberg

Propagating structure of Alzheimer's 13-amyloid(l(-35) 13407-13412 is parallel 3-sheet with residues in exact register

Tammie L. S. Benzinger, David M. Gregory, Timothy S. Burkoth, H6lene Miller-Auer, David G. Lynn, Robert E. Botto, and Stephen C. Meredith

Mitochondrial stress protein recognition of 13413-13418 inactivated dehydrogenases during mammalian cell death

Sam A. Bruschi, J. Gordon Lindsay, and John W. Crabb

An autonomous folding unit mediates the assembly 13419-13424 of two-stranded coiled coils

Richard A. Kammerer, Therese Schulthess, Ruth Landwehr, Ariel Lustig, Jargen Engel, Ueli Aebi, and Michel 0. Steinmetz

A general mechanism for regulation of access to the 13425-13430 translocon: Competition for a membrane attachment site on ribosomes

Ines M61ler, Martin Jung, Birgitta Beatrix, Robert Levy, Gert Kreibich, Richard Zimmermann, Martin Wiedmann, and Brett Lauring

M6ssbauer spectroscopy as a tool for the study of 13431-13435 activation/inactivation of the transcription regulator FNR in whole cells of Escherichia coli

Codrina V. Popescu, Donna M. Bates, Helmut Beinert, Eckard Miinck, and Patricia J. Kiley

Crystal structure of the ribosomal RNA domain 13436-13441 essential for binding elongation factors

Carl C. Correll, Alexander Munishkin, Yuen-Ling Chan, Zhong Ren, Ira G. Wool, and Thomas A. Steitz

Retinoic acid X receptor in the diploblast, 13442-13447 Tripedalia cystophora

Zdenek Kostrouch, Marta Kostrouchova, William Love, Emmanuele Jannini, Joram Piatigorsky, and J. Edward Rall

Oligomerization of activated D- and L-guanosine 13448-13452 mononucleotides on templates containing D- and L-deoxycytidylate residues

Igor A. Kozlov, Stefan Pitsch, and Leslie E. Orgel

Impaired osteoclastic bone resorption leads to 13453-13458 osteopetrosis in cathepsin-K-deficient mice

Paul Saftig, Ernst Hunziker, Olaf Wehmeyer, Sheila Jones, Alan Boyde, Winfried Rommerskirch, Jorg Detlev Moritz, Peter Schu, and Kurt von Figura

Defects in embryonic hindbrain development and 13459-13464 fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid

Jeffrey C. White, V. Narayanaswamy Shankar, Margaret Highland, Miles L. Epstein, Hector F.- DeLuca, and Margaret Clagett-Dame

The reactive site loop of the serpin SCCA1 is 13465-13470 essential for cysteine proteinase inhibition

Charles Schick, Dieter Bromme, Allison J. Bartuski, Yoshiki Uemura, Norman M. Schechter, and Gary A. Silverman

Unblocking of chain-terminated primer by HIV-1 13471-13476 reverse transcriptase through a nucleotide- dependent mechanism

Peter R. Meyer, Suzanne E. Matsuura, Antero G. So, and Walter A. Scott

Biosynthetic control of molecular weight in the 13477-13482 polymerization of the octasaccharide subunits of succinoglycan, a symbiotically important exopolysaccharide of Rhizobiuni nmeliloti

Juan E. Gonzalez, Carlos E. Semino, Lai-Xi Wang, Laura E. Castellano-Torres, and Graham C. Walker

TAFI, mutations disrupt Dorsal activation in the 13483-13488 Drosophila embryo

Jumin Zhou, Jork Zwicker, Paul Szymanski, Michael Levine, and Robert Tjian

Metal ion-mediated substrate-assisted catalysis 13489-13494 in type II restriction endonucleases

Nancy C. Horton, Kate Juliet Newberry, and John J. Perona

Aminoacylation of tRNA in the evolution of an 13495-13500 aminoacyl-tRNA synthetase

Richard S. A. Lipman and Ya-Ming Hou

Long-distance transcriptional enhancement by the 13501-13506 histone acetyltransferase PCAF

Anton Krumm, Linda Madisen, Xiang-Jiao Yang, Richard Goodman, Yoshihiro Nakatani, and Mark Groudine

A Rap protein is a structure-specific endonuclease 13507-13512 involved in phage recombination

Gary J. Sharples, Lisa M. Corbett, and Ian R. Graham

The lipid phosphatase activity of PTEN is critical 13513-13518 for its tumor supressor function

Michael P. Myers, Ian Pass, Ian H. Batty, Jeroen Van der Kaay, Javor P. Stolarov, Brian A. Hemmings, Michael H. Wigler, C. Peter Downes, and Nicholas K. Tonks

HIV-1 Tat transactivator recruits p300 and 13519-13524 CREB-binding protein histone acetyltransferases to the viral promoter

Giuseppe Marzio, Mudit Tyagi, Maria Ines Gutierrez, and Mauro Giacca

A streptavidin mutant with altered 13525-13530 ligand-binding specificity

Gabriel 0. Reznik, Sandor Vajda, Takeshi Sano, and Charles R. Cantor

Topoisomerase II-mediated site-directed alkylation 13531-13536 of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites

Yan Kwok, Qingping Zeng, and Laurence H. Hurley

iv

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Page 8: Front Matter

Contents

Capping and methylation of mRNA by purified 13537-13542 recombinant VP4 protein of bluetongue virus

N. Ramadevi, Nicholas J. Burroughs, Peter P. C. Mertens, Ian M. Jones, and Polly Roy

A transcriptional activating region with two 13543-13548 contrasting modes of protein interaction

Aseem Z. Ansari, Richard J. Reece, and Mark Ptashne

Chemical synthesis of the precursor molecule of the 13549-13554 Aequorea green fluorescent protein, subsequent folding, and development of fluorescence

Yuji Nishiuchi, Tatsuya Inui, IHideki Nishio, J6zsef B6di, Terutoshi Kimura, Frederick I. Tsuji, and Shumpei Sakakibara

MRG1, the product of a melanocyte-specific gene 13555-13560 related gene, is a cytokine-inducible transcription factor with transformation activity

Hui Bin Sun, Yuan Xiao Zhu, Tinggui Yin, George Sledge, and Yu-Chung Yang

A 55-kDa protein isolated from human cells shows 13561-13566 DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

B. Hang, M. Medina, H. Fraenkel-Conrat, and B. Singer

Roles of SecG in ATP- and SecA-dependent 13567-13572 protein translocation

Gen Matsumoto, Hiroyuki Mori, and Koreaki Ito

BIOPHYSICS

Dynamics of fluorescence fluctuations in green 13573-13578 fluorescent protein observed by fluorescence correlation spectroscopy

Ulrich Haupts, Sudipta Maiti, Petra Schwille, and Watt W. Webb

Electrostatic interaction between helical 13579-13584 macromolecules in dense aggregates: An impetus for DNA poly- and meso-morphism

Alexei A. Kornyshev and Sergey Leikin

TROSY in triple-resonance experiments: New 13585-13590 perspectives for sequential NMR assignment of large proteins

Michael Salzmann, Konstaritin Pervushin, Gerhard Wider, Hans Senn, and Kurt Wuithrich

Limited internal friction in the rate-limiting step 13591-13596 of a two-state protein folding reaction

Kevin W. Plaxco and Davicd Baker

Large-scale protein structure modeling of the 13597-13602 Saccharomyces cerevisiae genome

Roberto Sanchez and Andrej Sali

Ab initio calculation of electronic coupling in the 13603-13605 photosynthetic reaction center

Linda Yu Zhang and Richard A. Friesner

Proton uptake controls electron transfer in 13606-13611 cytochrome c oxidase

Martin Karpefors, Pia Adelroth, Yuejun Zhen, Shelagh Ferguson-Miller, and Peter Brzezinski

CELL BIOLOGY

Impairing follicle-stimulating hormone (FSH) 13612-13617 signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance

Andr6e Dierich, M. Ram Sairam, Lucia Monaco, Gian Maria Fimia, Anne Gansmuller, Marianne LeMeur, and Paolo Sassone-Corsi

Caspase-3 controls both cytoplasmic and nuclear 13618-13623 events associated with Fas-mediated apoptosis in vivo

Timothy S. Zheng, Stephan F. Schlosser, Tao Dao, Ravi Hingorani, I. Nicholas Crispe, James L. Boyer, and Richard A. Flavell

An HP1-like protein is missing from transcriptionally 13624-13629 silent micronuclei of Tetrahymena

Hui Huang, Emily A. Wiley, Craig R. Lending, and C. David Allis

Characterization of two patched receptors for the 13630-13634 vertebrate hedgehog protein family

David Carpenter, Donna M. Stone, Jennifer Brush, Anne Ryan, Mark Armanini, Gretchen Frantz, Arnon Rosenthal, and Frederic J. de Sauvage

A novel structure involved in the formation of liver 13635-13640 endothelial cell fenestrae revealed by using the actin inhibitor misakinolide

Filip Braet, Ilan Spector, Ronald De Zanger, and Eddie Wisse

Chloride is an allosteric effector of copper assembly 13641-13645 for the yeast multicopper oxidase Fet3p: An unexpected role for intracellular chloride channels

Sandra R. Davis-Kaplan, Candice C. Askwith, Andrea C. Bengtzen, Derek Radisky, and Jerry Kaplan

v-K-ras leads to preferential farnesylation of p21'as 13646-13651 in FRTL-5 cells: Multiple interference with the isoprenoid pathway

Chiara Laezza, Vincenzo Di Marzo, and Maurizio Bifulco

Myosin II localization during cytokinesis occurs by a 13652-13657 mechanism that does not require its motor domain

Ji-Hong Zang and James A. Spudich

Involvement of focal adhesion kinase in 13658-13663 invasin-mediated uptake

Michael A. Alrutz and Ralph R. Isberg

Oncogene-dependent apoptosis is mediated 13664-13669 by caspase-9

Howard 0. Fearnhead, Joe Rodriguez, Eve-Ellen Govek, Wenjun Guo, Ryuji Kobayashi, Greg Hannon, and Yuri A. Lazebnik

Graded transcriptional response to different 13670-13675 concentrations of a single transactivator

Andrew M. Kringstein, Fabio M. V. Rossi, Andreas Hofmann, and Helen M. Blau

ADP-ribosylation factor and phosphatidic acid levels 13676-13680 in Golgi membranes during budding of coatomer-coated vesicles

Mark Stamnes, Giampietro Schiavo, Gudrun Stenbeck, Thomas H. Sollner, and James E. Rothman

v

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Page 9: Front Matter

Contents

Specific interaction of mutant p53 with regions of 13681-13686 matrix attachment region DNA elements (MARs) with a high potential for base-unpairing

Katrin Will, Gabriele Warnecke, Lisa Wiesmuiller, and Wolfgang Deppert

Retinoic acid alters the intracellular trafficking 13687-13691 of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes

Jing X. Kang, Jennifer Bell, Alexander Leaf, Richard L. Beard, and Roshantha A. S. Chandraratna

Genetic instability of cancer cells is proportional to 13692-13697 their degree of aneuploidy

Peter Duesberg, Charlotte Rausch, David Rasnick, and Ruediger Hehlmann

Termination of signaling by protease-activated 13698-13702 receptor-i is linked to lysosomal sorting

JoAnn Trejo, Stephen R. Hammes, and Shaun R. Coughlin

Transgenic Drosophila expressing human amyloid 13703-13708 precursor protein show y-secretase activity and a blistered-wing phenotype

Anke Fossgreen, Bodo Bruckner, Christian Czech, Colin L. Masters, Konrad Beyreuther, and Renato Paro

DEVELOPMENTAL BIOLOGY

RNA helicase A is essential for normal gastrulation 13709-13713 Chee-Gun Lee, Vera da Costa Soares, Carol Newberger, Katia Manova, Elizabeth Lacy, and Jerard Hurwitz

AP-2-null cells disrupt morphogenesis of the eye, 13714-13719 face, and limbs in chimeric mice

Timothy Nottoli, Stephanie Hagopian-Donaldson, Jian Zhang, Archibald Perkins, and Trevor Williams

Lune/eye gone, a Pax-like protein, uses a partial 13720-13725 paired domain and a homeodomain for DNA recognition

Susie Jun, Robert V. Wallen, Anne Goriely, Bill Kalionis, and Claude Desplan

Derivation of pluripotent stem cells from cultured 13726-13731 human primordial germ cells

Michael J. Shamblott, Joyce Axelman, Shunping Wang, Elizabeth M. Bugg, John W. Littlefield, Peter J. Donovan, Paul D. Blumenthal, George R. Huggins, and John D. Gearhart

EVOLUTION

Polyandrous females discriminate against 13732-13736 previous mates

Jeanne A. Zeh, Scott D. Newcomer, and David W. Zeh

Dispersal of first "workers" in social wasps: Causes 13737-13742 and implications of an alternative reproductive strategy

H. Kern Reeve, John M. Peters, Peter Nonacs, and Philip T. Starks

Chemical phenotype matching between a plant 13743-13748 and its insect herbivore

May R. Berenbaum and Arthur R. Zangerl

Origins and antiquity of X-linked triallelic color 13749-13754 vision systems in New World monkeys

Stephane Boissinot, Ying Tan, Song-Kun Shyue, Horacio Schneider, Iracilda Sampaio, Katherine Neiswanger, David Hewett-Emmett, and Wen-Hsiung Li

Working memory constrains human cooperation 13755-13758 in the Prisoner's Dilemma

Manfred Milinski and Claus Wedekind

GENETICS

Carcinogen-induced loss of heterozygosity at the 13759-13764 Aprt locus in somatic cells of the mouse

Susan W. P. Wijnhoven, Petra P. H. Van Sloun, Hanneke J. M. Kool, Geert Weeda, Rosalyn Slater, Paul H. M. Lohman, Albert A. van Zeeland, and Harry Vrieling

Inactivating mutations in an SH2 domain-encoding 13765-13770 gene in X-linked lymphoproliferative syndrome

Kim E. Nichols, D. Paul Harkin, Seth Levitz, Michael Krainer, Kathryn Ann Kolquist, Cameo Genovese, Amy Bernard, Martin Ferguson, Lin Zuo, Eric Snyder, Alan J. Buckler, Carol Wise, Jennifer Ashley, Michael Lovett, Marcus B. Valentine, A. Thomas Look, William Gerald, David E. Housman, and Daniel A. Haber U See Commentary on page 13355

Ribosomes can slide over and beyond "hungry" 13771-13776 codons, resuming protein chain elongation many nucleotides downstream

Jonathan A. Gallant and Dale Lindsley

The AMPA receptor subunit GluR-B in its Q/R 13777-13782 site-unedited form is not essential for brain development and function

Kalev Kask, Daniel Zamanillo, Andrei Rozov, Nail Burnashev, Rolf Sprengel, and Peter H. Seeburg

The three yeast A kinases have specific signaling 13783-13787 functions in pseudohyphal growth

Laura S. Robertson and Gerald R. Fink

Reciprocal subtraction differential RNA display: An 13788-1 3793 efficient and rapid procedure for isolating differentially expressed gene sequences

Dong-chul Kang, Raphael LaFrance, Zao-zhong Su, and Paul B. Fisher

Characterization of the Saccharomyces cerevisiae 13794-13799 ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis

D. Gachotte, R. Barbuch, J. Gaylor, E. Nickel, and M. Bard

Rump white inversion in the mouse disrupts 13800-13805 dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression

R. Barry Hough, Andreas Lengeling, Vahe Bedian, Cecilia Lo, and Maja Bucan

vi

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Page 10: Front Matter

Contents

IMMUNOLOGY

Inhibition of interferon y induced interleukin 12 13806-13811 production: A potential mechanism for the anti-inflammatory activities of tumor necrosis factor

Jennifer Hodge-Dufour, Michael W. Marino, Maureen R. Horton, Achim Jungbluth, Marie D. Burdick, Robert M. Strieter, Paul W. Noble, Christopher A. Hunter, and Ellen Pur6

Characteristics of virus-specific CD8+ T cells in the 13812-13817 liver during the control and resolution phases of influenza pneumonia

Gabrielle T. Belz, John D. Altman, and Peter C. Doherty

Mechanisms of 3 cell death in diabetes: A minor 13818-13822 role for CD95

Janette Allison and Andreas Strasser

T helper type 2 inflammatory disease in the absence 13823-13828 of interleukin 4 and transcription factor STAT6

Alexander L. Dent, Jane Hu-Li, William E. Paul, and Louis M. Staudt

MEDICAL SCIENCES

Mitochondrial stress protein recognition of 13413-13418 inactivated dehydrogenases during mammalian cell death

Sam A. Bruschi, J. Gordon Lindsay, and John W. Crabb

Impaired liver regeneration in inducible nitric oxide 13829-13834 synthase-deficient mice

Rudra M. Rai, Fung Yee J. Lee, Anthony Rosen, Shi Qi Yang, Hui Zhi Lin, Ayman Koteish, Foo Y. Liew, Carlos Zaragoza, Charles Lowenstein, and Anna Mae Diehl

Dissociation between bone resorption and bone 13835-13840 formation in osteopenic transgenic mice

David A. Corral, Michael Amling, Matthias Priemel, Evelyn Loyer, Sebastien Fuchs, Patricia Ducy, Roland Baron, and Gerard Karsenty * See Commentary on page 13361

Catalytically inactive lipoprotein lipase expression in 13841-13846 muscle of transgenic mice increases very low density lipoprotein uptake: Direct evidence that lipoprotein lipase bridging occurs in vivo

Martin Merkel, Yuko Kako, Herbert Radner, Irene S. Cho, Ravi Ramasamy, John D. Brunzell, Ira J. Goldberg, and Jan L. Breslow

Adeno-associated viral-mediated catalase expression 13847-13852 suppresses optic neuritis in experimental allergic encephalomyelitis

John Guy, Xiaoping Qi, and William W. Hauswirth

A model for spontaneous B-lineage lymphomas in 13853-13858 IgJH,t-HOXJ1l transgenic mice

Margaret R. Hough, Marciano D. Reis, Roshni Singaraja, Dawn Marie Bryce, Suzanne Kamel-Reid, Irving Dardick, Martin L. Breitman, and Ian D. Dube

NF-KB activation provides the potential link between 13859-13864 inflammation and hyperplasia in the arthritic joint

Alexei V. Miagkov, Dmitry V. Kovalenko, Chadwick E. Brown, John R. Didsbury, John P. Cogswell, Stephen A. Stimpson, Albert S. Baldwin, and Sergei S. Makarov

Peptide inhibitors of HIV-1 protease and viral 13865-13868 infection of peripheral blood lymphocytes based on HIV-1 Vif

Mary Jane Potash, Galina Bentsman, Tom Muir, Chavdar Krachmarov, Pavel Sova, and David J. Volsky

The BRCA2 gene product functionally interacts with 13869-13874 p53 and RAD51

Lihua Y. Marmorstein, Toru Ouchi, and Stuart A. Aaronson

Anti-CD14 mAb treatment provides therapeutic 13875-13880 benefit after in vivo exposure to endotoxin

Jan Schimke, John Mathison, Janice Morgiewicz, and Richard J. Ulevitch

Modeling the impact of global tuberculosis 13881-13886 control strategies

Christopher J. L. Murray and Joshua A. Salomon * See Commentary on page 13352

c-Myc target gene specificity is determined by a 13887-13892 post-DNA-binding mechanism

Kathryn E. Boyd, Julie Wells, Julie Gutman, Stephanie M. Bartley, and Peggy J. Farnham

Transient cardiac expression of constitutively active 13893-13898 Gaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

U. Mende, A. Kagen, A. Cohen, J. Aramburu, F. J. Schoen, and E. J. Neer

MICROBIOLOGY

ExoY, an adenylate cyclase secreted by the 13899-13904 Pseudomonas aeruginosa type III system

Timothy L. Yahr, Amy J. Vallis, Michael K. Hancock, Joseph T. Barbieri, and Dara W. Frank

Hybrid Tyl/HIV-1 elements used to detect 13905-13910 inhibitors and monitor the activity of HIV-1 reverse transcriptase

Dwight V. Nissley, Paul L. Boyer, David J. Garfinkel, Stephen H. Hughes, and Jeffrey N. Strathern

U94 of human herpesvirus 6 is expressed in latently 13911-13916 infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture

Antonella Rotola, Tullia Ravaioli, Arianna Gonelli, Stephen Dewhurst, Enzo Cassai, and Dario Di Luca

Vaccinia locomotion in host cells: Evidence for the 13917-13922 universal involvement of actin-based motility sequences ABM-1 and ABM-2

William L. Zeile, Richard C. Condit, Jackie I. Lewis, Daniel L. Purich, and Frederick S. Southwick

vii

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Page 11: Front Matter

Contents

A family of phase-variable restriction enzymes with 13923-13928 differing specificities generated by high-frequency gene rearrangements

Kevin Dybvig, Ramakrishnan Sitaraman, and C. Todd French

NEUROBIOLOGY

Leading role of thalamic over cortical neurons 13929-13934 during postinhibitory rebound excitation

F. Grenier, I. Timofeev, and M. Steriade

Functional redundancy of acetylcholinesterase and 13935-13940 neuroligin in mammalian neuritogenesis

Mirta Grifman, Nilly Galyam, Shlomo Seidman, and Hermona Soreq

Estrogen alters behavior and forebrain c-fos 13941-13946 expression in ovariectomized rats subjected to the forced swim test

Ilya M. Rachman, James R. Unnerstall, Donald W. Pfaff, and Rochelle S. Cohen

PHARMACOLOGY

Interaction of batrachotoxin with the local anesthetic 13947-1.3952 receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

Nancy J. Linford, Angela R. Cantrell, Yusheng Qu, Todd Scheuer, and William A. Catterall

PHYSIOLOGY

KAFP channel inhibition by ATP requires distinct 13953-13958 functional domains of the cytoplasmic C terminus of the pore-forming subunit

Peter Drain, Lehong Li, and Jing Wang

PLANT BIOLOGY

Virus resistance and gene silencing in plants can be 13959-13964 induced by simultaneous expression of sense and antisense RNA

Peter M. Waterhouse, Michael W. Graham, and Ming-Bo Wang * See Commentary on page 13349

A Pll-like protein in Arabidopsis: Putative role in 13965-13970 nitrogen sensing

Ming-Hsiun Hsieh, Hon-Ming Lam, Frank J. van de Loo, and Gloria Coruzzi

Concerted biosynthesis of an insect elicitor of 13971-13975 plant volatiles

P. W. Par6, H. T. Alborn, and J. H. Tumlinson

Eukaryotic phytochromes: Light-regulated 13976-13981 serine/threonine protein kinases with histidine kinase ancestry

Kuo-Chen Yeh and J. Clark Lagarias * See Commentary on page 13358

PSYCHOLOGY

Movement analysis in infancy may be useful for 13982-13987 early diagnosis of autism

Philip Teitelbaum, Osnat Teitelbaum, Jennifer Nye, Joshua Fryman, and Ralph G. Maurer

Perceptual learning reflects external noise 13988-13993 filtering and internal noise reduction through channel reweighting

Barbara Anne Dosher and Zhong-Lin Lu

Social Sciences

ANTHROPOLOGY

The origin of the Na-Dene 13994-13996 Merritt Ruhlen

CORRECTIONS

GENETICS The reductive enzyme thioredoxin 1 acts as an 13997 oxidant when it is exported to the Esche-ichia coli periplasm

Laurent Debarbieux and Jon Beckwith

PLANT BIOLOGY Sucrose is a signal molecule in assimilate partitioning 13997

Tzyy-Jen Chiou and Daniel R. Bush

AUTHOR INDEX xi-xiii

INFORMATION FOR AUTHORS xiv-xvi

SIZING WORKSHEET xvii

DOCUMENTATION REPORT xviii

COPYRIGHT ASSIGNMENT FORM xix

CLASSIFIED ADVERTISEMENTS xx-xxi

Cover photograph: Watt with flywheel and gears recalling the invention of the condensing steam engine: Panel from the bronze doors at the National Academy of Sciences.

viii

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Page 12: Front Matter

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Page 13: Front Matter

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