Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 14 (Jul. 16, 1999), pp. i-x Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/48342 . Accessed: 08/05/2014 02:45 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.137 on Thu, 8 May 2014 02:45:43 AM All use subject to JSTOR Terms and Conditions
Transcript
Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 96, No. 14 (Jul. 16, 1999), pp. i-xPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/48342 .
Accessed: 08/05/2014 02:45
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.
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PNAS Proceedings of the National Academy of Sciences of the United States of America
July 6, 1999 vol. 96 no. 14 pp. 7611-8308 vwww.pnas.org
Neural plasticity in the thalamus Cytochrome-c-mediated apoptosis in heart failure Benzene, NQO 1, and susceptibility to cancer Game theory model for language evolution Fungal parasite in ant fungus gardens
The Neurobiology of Pain
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GENEF ILTEoRS MICROARRAYS CONSISTING OF THE DNAt INSERTS FROM TENS OF
THOL ANDS.. .OF SEQUENCE VALIDATED CLONES GENEFILTERS microarrays contain DNA from over 5,000 different genes spotted onto nylon membranes. Over
25,000 genes are represented in our growing collection of sequence validated I.M.A.G.E./LLNL clones1 chosen from the UniGene2 set. In addition to five GENEFILTERS microarrays representing the entire human collection, individual GENEFILTERs are available which represent only named human genes or only genes that have been shown to be expessed in a particular human tissue. The first release of our rat GENEFILTERS microarrays is now available also.2:' :This collection of over 5,000 genes represents about 1,700 named rat genes3 as well as many rat ESTs that are considered similar to named genes in other organisms. GENEFILTERS microarrays are high density DNA arrays produced on. 5cm x 7cm membranes. These tools offer''
the opportunity to carry out sophisticated, genome-wide gene expression experiments using simple autoradiography. ENaKXERS can be probed up to six times. Standard hybridization methods with 33P and a phosphor imaging system produce data which can be analyzed using PathwaysTM analysis software. For a complete description of each of thet GENEFILTERS microarrays, see our web site at http://www.resgen.com. Ref 1. Lennon, G., Auffray, C., Polymeropoulos, M., Soares, M.B. (1996) Genomics 33, 151-152.
Cat. No. Descriptioni` Price GF200 Hman "GENEFILTERS Release I $ 960.00U GF201 Human GENFLTERS Release II $ 960.00 GF202 Human GENEFILTERs Release III $ 960.00 GF203 Human GENEFILTERs Release IV $ 960.00 GF204 Human GENEFILTERs Release V $ 960.00
Cat. No. Description Price GF300 Rat GENEFILTERs Release I $ 960.00 GF221 Human Prostate GENEFILTERS $1,440.00 GF224 Human Ovary GENEFILTRs $1,440.00 GF211 Human Named Genes GENEFILTERS $1,440.00
-~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~OES_ 1 .2 r ~jf
PathwaysTM software was designed specifically for use with GENEFILTERS microarrays. The software imports and stores .gel or .tif files- from phosphor imaging systems, and locates, calculates, and stores the spot intensities from those files. The softwae is capable of analyzing images from single membranes or graphically comparing two different images, as well as "bookmarking" genes of interest for easy future reference. An intuitive histogram tool allows easy selection of genes with differential expression. The internal database provides instant, on-screen identification of each spot as it is selected. Additionally, PathwaysTM will export the data to reports, text files, and/or spreadsheets complete with GenBank accession numbers.
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More than one way to see it move? 7611-7613 Thomas D. Albright * See companion article on page 8289
Postmitochondrial regulation of apoptosis during 7614-7616 heart failure
John C. Reed and Giovanni Paternostro * See companion article on page 8144
Sorting out mutation rates 7617-7618 Patricia L. Foster * See companion article on page 6847 in issue 12 of volume 96
Convicting a human tumor virus: Guilt by association? 7619-7621 John A. Blaho and Stuart A. Aaronson * See companion article on page 7484 in issue 13 of volume 96
Is most of neural plasticity in the thalamus cortical? 7622-7623 Jon H. Kaas * See companion article on page 8200
Benzene, NQO1, and genetic susceptibility to cancer 7624-7626 Martyn T. Smith * See companion article on page 8150
Papers from a National Academy of Sciences Colloquium on The Neurobiology of Pain
The neurobiology of pain 7627-7630 Ronald Dubner and Michael Gold
John C. Liebeskind (1935-1997): A tribute 7631-7634 Gregory W. Terman
Sodium channels and pain 7635-7639 S. G. Waxman, S. Dib-Hajj, T. R. Cummins, and J. A. Black
A comparison of the potential role of the 7640-7644 tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain
Frank Porreca, Josephine Lai, Di Bian, Sandra Wegert, Michael H. Ossipov, Richard M. Eglen, Laura Kassotakis, Sanja Novakovic, Douglas K. Rabert, Lakshmi Sangameswaran, and John C. Hunter
Tetrodotoxin-resistant Na+ currents and 7645-7649 inflammatory hyperalgesia
Michael S. Gold
Calcium regulation of a slow post-spike 7650-7657 hyperpolarization in vagal afferent neurons
Ruth Cordoba-Rodriguez, Kimberly A. Moore, Joseph P. Y. Kao, and Daniel Weinreich
iii
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P. Cesare, A. Moriondo, V. Vellani, and P. A. McNaughton
Causalgia, pathological pain, and adrenergic receptors 7664-7667 Edward R. Perl
Forebrain mechanisms of nociception and pain: 7668-7674 Analysis through imaging
Kenneth L. Casey
A visceral pain pathway in the dorsal column of the 7675-7679 spinal cord
William D. Willis, Elie D. Al-Chaer, Michael J. Quast, and Karin N. Westlund
The spinal biology in humans and animals of pain 7680-7686 states generated by persistent small afferent input
Tony L. Yaksh, Xiao-Ying Hua, Iveta Kalcheva, Natsuko Nozaki-Taguchi, and Martin Marsala
Supraspinal contributions to hyperalgesia 7687-7692 M. 0. Urban and G. F. Gebhart
Neurotrophins and hyperalgesia 7693-7696 X.-Q. Shu and L. M. Mendell
Src, a molecular switch governing gain control of 7697-7704 synaptic transmission mediated by N-methyl-D-aspartate receptors
Xian-Min Yu and Michael W. Salter
Pain perception: Is there a role for primary 7705-7709 somatosensory cortex?
M. C. Bushnell, G. H. Duncan, R. K. Hofbauer, B. Ha, J.-I. Chen, and B. Carrier
Implications of immune-to-brain communication for 7710-7713 sickness and pain
Linda R. Watkins and Steven F. Maier
Brain-derived neurotrophic factor is an endogenous 7714-7718 modulator of nociceptive responses in the spinal cord
S. W. N. Thompson, D. L. H. Bennett, B. J. Kerr, E. J. Bradbury, and S. B. McMahon
The postnatal development of spinal 7719-7722 sensory processing
Maria Fitzgerald and Ernest Jennings
Transcriptional and posttranslational plasticity and the 7723-7730 generation of inflammatory pain
Clifford J. Woolf and Michael Costigan
Cellular mechanisms of neuropathic pain, morphine 7731-7736 tolerance, and their interactions
David J. Mayer, Jianren Mao, Jason Holt, and Donald D. Price
Does a neuroimmune interaction contribute to the 7737-7738 genesis of painful peripheral neuropathies?
Gary J. Bennett
Distinct neurochemical features of acute and 7739-7743 persistent pain
Allan I. Basbaum
The genetic mediation of individual differences in 7744-7751 sensitivity to pain and its inhibition
Jeffrey S. Mogil
The p opiate receptor as a candidate gene for pain: 7752-7755 Polymorphisms, variations in expression, nociception, and opiate responses
George R. Uhl, Ichiro Sora, and Zaijie Wang
Inaugural Article
Vortices in rotating superfluid 3He 7760-7767 Olli V. Lounasmaa and Erkki Thuneberg
Physical Sciences
APPLIED PHYSICAL SCIENCES
A continuous topological change during phase 7756-7759 transitions in amphiphile/water systems
Sergio S. Funari and Gert Rapp
PHYSICS
Vortices in rotating superfluid 3He 7760-7767 Olli V. Lounasmaa and Erkki Thuneberg
Biological Sciences
APPLIED BIOLOGICAL SCIENCES
A dimeric mutant of human pancreatic ribonuclease 7768-7773 with selective cytotoxicity toward malignant cells
Renata Piccoli, Sonia Di Gaetano, Claudia De Lorenzo, Michela Grauso, Carmen Monaco, Daniela Spalletti-Cernia, Paolo Laccetti, Jaroslav Cinatl, Josef Matousek, and Giuseppe D'Alessio
Protective immunity against murine hepatitis virus 7774-7779 (MHV) induced by intranasal or subcutaneous administration of hybrids of tobacco mosaic virus that carries an MHV epitope
Moses Koo, Mohammed Bendahmane, Gerard A. Lettieri, Alyssa D. Paoletti, Thomas E. Lane, John H. Fitchen, Michael J. Buchmeier, and Roger N. Beachy
BIOCHEMISTRY
The y-subunit rotation and torque generation in 7780-7784 F1-ATPase from wild-type or uncoupled mutant Escherichia coli
Structure of the subunit c oligomer in the FjF0 ATP 7785-7790 synthase: Model derived from solution structure of the monomer and cross-linking in the native enzyme
Oleg Y. Dmitriev, Phil C. Jones, and Robert H. Fillingame
Recruitment of cyclin Tl/P-TEFb to an HIV type 1 7791-7796 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription
Paul D. Bieniasz, Therese A. Grdina, Hal P. Bogerd, and Bryan R. Cullen
iv
This content downloaded from 169.229.32.137 on Thu, 8 May 2014 02:45:43 AMAll use subject to JSTOR Terms and Conditions
Lovastatin-mediated Gi arrest is through inhibition of 7797-7802 the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
Sharmila Rao, Donald C. Porter, Xiaomei Chen, Thaddeus Herliczek, Michael Lowe, and Khandan Keyomarsi
RNase P RNAs from some Archaea are 7803-7808 catalytically active
James A. Pannucci, Elizabeth S. Haas, Thomas A. Hall, J. Kirk Harris, and James W. Brown
Peroxynitrite-mediated modification of proteins at 7809-7814 physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation
Ming Tien, Barbara S. Berlett, Rodney L. Levine, P. Boon Chock, and Earl R. Stadtman
A protein-protein interaction map of yeast RNA 7815-7820 polymerase III
A. Flores, J.-F. Briand, 0. Gadal, J.-C. Andrau, L. Rubbi, V. Van Mullem, C. Boschiero, M. Goussot, C. Marck, C. Carles, P. Thuriaux, A. Sentenac, and M. Werner
Kinase interaction domain of kinase-associated 7821-7826 protein phosphatase, a phosphoprotein- binding domain
Jia Li, George P. Smith, and John C. Walker
The in situ spatial arrangement of the influenza 7827-7830 A virus matrix protein Ml assessed by tritium bombardment
Alexander V. Shishkov, Vitalii I. Goldanskii, Ludmila A. Baratova, Natalia V. Fedorova, Alexander L. Ksenofontov, Oleg P. Zhirnov, and Alexander V. Galkin
NIH shift in flavin-dependent monooxygenation: 7831-7836 Mechanistic studies with 2-aminobenzoyl- CoA monooxygenase/reductase
Steffen Hartmann, Claus Hultschig, Wolfgang Eisenreich, Georg Fuchs, Adelbert Bacher, and Sandro Ghisla
Adhesive properties of the isolated amino-terminal 7837-7842 domain of platelet glycoprotein Iba in a flow field
Patrizia Marchese, Enrique Saldivar, Jerry Ware, and Zaverio M. Ruggeri
Selective interaction of the C2 domains of 7843-7846 phospholipase C-p1 and -32 with activated Gaq subunits: An alternative function for C2-signaling modules
Tieli Wang, Srinivas Pentyala, John T. Elliott, Louisa Dowal, Ekta Gupta, Mario J. Rebecchi, and Suzanne Scarlata
Identification of the endonuclease domain encoded by 7847-7852 R2 and other site-specific, non-long terminal repeat retrotransposable elements
Jin Yang, Harmit S. Malik, and Thomas H. Eickbush
A more unified picture for the thermodynamics of 7853-7858 nucleic acid duplex melting: A characterization by calorimetric and volumetric techniques
Tigran V. Chalikian, Jens Volker, G. Eric Plum, and Kenneth J. Breslauer
Functional interaction between human topoisomerase 7859-7864 Ila and retinoblastoma protein
Uppoor G. Bhat, Pradip Raychaudhuri, and William T. Beck
Design, total chemical synthesis, and binding 7865-7870 properties of a [Leu-91-NL-methyl-7-azaTrp]Ras- binding domain of c-Raf-1
Jens R. Sydor, Christian Herrmann, Stephen B. H. Kent, Roger S. Goody, and Martin Engelhard
Single-nucleotide polymorphisms can cause different 7871-7876 structural folds of mRNA
Ling X. Shen, James P. Basilion, and Vincent P. Stanton, Jr.
BIOPHYSICS
Structure of the soluble methane monooxygenase 7877-7882 regulatory protein B
Kylie J. Walters, George T. Gassner, Stephen J. Lippard, and Gerhard Wagner
Self-assembly of helical ribbons 7883-7887 Yevgeniya V. Zastavker, Neer Asherie, Aleksey Lomakin, Jayanti Pande, Joanne M. Donovan, Joel M. Schnur, and George B. Benedek
Folding of a pressure-denatured model protein 7888-7893 Ronaldo Mohana-Borges, Jerson L. Silva, Javier Ruiz-Sanz, and Gonzalo de Prat-Gay
Atomic levers control pyranose ring conformations 7894-7898 Piotr E. Marszalek, Yuan-Ping Pang, Hongbin Li, Jamal El Yazal, Andres F. Oberhauser, and Julio M. Fernandez
Native-state hydrogen-exchange studies of a fragment 7899-7904 complex can provide structural information about the isolated fragments
G. Chakshusmathi, Girish S. Ratnaparkhi, P. K. Madhu, and R. Varadarajan
Role of the nonheme Fe(II) center in the biosynthesis 7905-7909 of the plant hormone ethylene
Amy M. Rocklin, David L. Tierney, Victoria Kofman, Norbert M. W. Brunhuber, Brian M. Hoffman, Rolf E. Christoffersen, Norbert 0. Reich, John D. Lipscomb, and Lawrence Que, Jr.
Validation of the single-stranded channel 7910-7915 conformation of gramicidin A by solid-state NMR
F. Kovacs, J. Quine, and T. A. Cross
RecA polymerization on double-stranded DNA by 7916-7921 using single-molecule manipulation: The role of ATP hydrolysis
G. V. Shivashankar, M. Feingold, 0. Krichevsky, and A. Libchaber
CELL BIOLOGY
Five-transmembrane domains appear sufficient for a 7922-7927 G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors
Kun Ling, Ping Wang, Jian Zhao, Ya-Lan Wu, Zhi-Jie Cheng, Guo-Xiang Wu, Wei Hu, Lan Ma, and Gang Pei
v
This content downloaded from 169.229.32.137 on Thu, 8 May 2014 02:45:43 AMAll use subject to JSTOR Terms and Conditions
Contents Arrangement of radial actin bundles in the growth 7928-7931 cone of Aplysia bag cell neurons shows the immediate past history of filopodial behavior
Kaoru Katoh, Katherine Hammar, Peter J. S. Smith, and Rudolf Oldenbourg
Endogenous presenilin 1 redistributes to the surface 7932-7937 of lamellipodia upon adhesion of Jurkat cells to a collagen matrix
Alexander L. Schwarzman, Nandita Singh, Maria Tsiper, Luisa Gregori, Alex Dranovsky, Michael P. Vitek, Charles G. Glabe, Peter H. St. George-Hyslop, and Dmitry Goldgaber
Ran-independent nuclear import of cyclin B1-Cdc2 by 7938-7943 importin P
Catherine G. Takizawa, Karsten Weis, and David 0. Morgan
02 sensing is preserved in mice lacking the gp9l phox 7944-7949 subunit of NADPH oxidase
Stephen L. Archer, Helen L. Reeve, Evangelos Michelakis, Lakshmi Puttagunta, Ross Waite, Daniel P. Nelson, Mary C. Dinauer, and E. Kenneth Weir
Time-resolved analysis and visualization of dynamic 7950-7955 processes in living cells
W. Tvarusk6, M. Bentele, T. Misteli, R. Rudolf, C. Kaether, D. L. Spector, H. H. Gerdes, and R. Eils
Bax-induced cell death in tobacco is similar to the 7956-7961 hypersensitive response
Christophe Lacomme and Simon Santa Cruz
Nephrin is specifically located at the slit diaphragm of 7962-7967 glomerular podocytes
Vesa Ruotsalainen, Paivi Ljungberg, Jorma Wartiovaara, Ulla Lenkkeri, Marjo Kestila, Hannu Jalanko, Christer Holmberg, and Karl Tryggvason
p200 ARF-GEP1: A Golgi-localized guanine 7968-7973 nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A
Sam J. Mansour, Jennifer Skaug, Xin-Hua Zhao, Jennifer Giordano, Stephen W. Scherer, and Paul Melancon
Nuclear and cell membrane effects contribute 7974-7979 independently to the induction of apoptosis in human cells exposed to UVB radiation
Dagmar Kulms, Birgit Poppelmann, Daniel Yarosh, Thomas A. Luger, Jean Krutmann, and Thomas Schwarz
Nuclear localization of the pl2Octn Armadillo-like 7980-7985 catenin is counteracted by a nuclear export signal and by E-cadherin expression
J. van Hengel, P. Vanhoenacker, K. Staes, and F. van Roy
DEVELOPMENTAL BIOLOGY
Impairment of spermatogenesis in mice lacking a 7986-7991 functional aromatase (cyp 19) gene
Kirsten M. Robertson, Liza O'Donnell, Margaret B. B. Jones, Sarah J. Meachem, Wah Chin Boon, Carolyn R. Fisher, Kathy H. Graves, Robert I. McLachlan, and Evan R. Simpson
DIO-1 is a gene involved in onset of apoptosis in vitro, 7992-7997 whose misexpression disrupts limb development
David Garcia-Domingo, Esther Leonardo, Alf Grandien, Pedro Martinez, Juan Pablo Albar, Juan Carlos Izpisuia-Belmonte, and Carlos Martinez-A
ECOLOGY
The agricultural pathology of ant fungus gardens 7998-8002 Cameron R. Currie, Ulrich G. Mueller, and David Malloch
Influence of drinking water and diet on the 8003-8006 stable-hydrogen isotope ratios of animal tissues
Keith A. Hobson, Lisa Atwell, and Leonard I. Wassenaar
Damage to photosystem II in symbiotic 8007-8012 dinoflagellates: A determinant of coral bleaching
Mark E. Warner, William K. Fitt, and Gregory W. Schmidt
Species richness and resource availability: A 8013-8016 phylogenetic analysis of insects associated with trees
C. K. Kelly and T. R. E. Southwood
EVOLUTION
Diversity of Holocene life forms in fossil glacier ice 8017-8021 Eske Willerslev, Anders J. Hansen, Bent Christensen, J0rgen Peder Steffensen, and Peter Arctander
Evidence that a plant virus switched hosts to infect a 8022-8027 vertebrate and then recombined with a vertebrate-infecting virus
Mark J. Gibbs and Georg F. Weiller
The evolution of language 8028-8033 Martin A. Nowak and David C. Krakauer
The nop-1 gene of Neurospora crassa encodes a seven 8034-8039 transmembrane helix retinal-binding protein homologous to archaeal rhodopsins
Jennifer A. Bieszke, Edward L. Braun, Laura E. Bean, Seogchan Kang, Donald 0. Natvig, and Katherine A. Borkovich
GENETICS
A human DAZ transgene confers partial rescue of the 8040-8045 mouse Dazl null phenotype
R. Slee, B. Grimes, R. M. Speed, M. Taggart, S. M. Maguire, A. Ross, N. I. McGill, P. T. K. Saunders, and H. J. Cooke
Stability of the mitochondrial genome requires an 8046-8051 amino-terminal domain of yeast mitochondrial RNA polymerase
Yuanhong Wang and Gerald S. Shadel
Myxococcus cells respond to elastic forces in 8052-8057 their substrate
Marta Fontes and Dale Kaiser
vi
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Contents Analysis of human peripheral blood T cells and 8058-8063 single-cell-derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome
Xiaoxiang Zhu, Chun Deng, Rork Kuick, Raymond Yung, Barbara Lamb, James V. Neel, Bruce Richardson, and Samir Hanash
A maternally methylated CpG island in KvLQTI is 8064-8069 associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome
Nancy J. Smilinich, Colleen D. Day, Galina V. Fitzpatrick, Germaine M. Caldwell, Amy C. Lossie, P. R. Cooper, Allan C. Smallwood, Johanna A. Joyce, Paul N. Schofield, Wolf Reik, Robert D. Nicholls, Rosanna Weksberg, D. J. Driscoll, Eamonn R. Maher, Thomas B. Shows, and Michael J. Higgins
SIAH-1 promotes apoptosis and tumor suppression 8070-8073 through a network involving the regulation of protein folding, unfolding, and trafficking: Identification of common effectors with p53 and p2lwafl
Jean-Pierre Roperch, Florence Lethrone, Sylvie Prieur, Laurence Piouffre, David Israeli, Marcel Tuynder, Mona Nemani, Patricia Pasturaud, Marie-Claude Gendron, Jean Dausset, Moshe Oren, Robert B. Amson, and Adam Telerman
Exon shuffling mimicked in cell culture 8074-8079 Anke A. F. van Rijk, Wilfried W. de Jong, and Hans Bloemendal
IMMUNOLOGY
IL-4 enhances proliferation and mediator release in 8080-8085 mature human mast cells
S. C. Bischoff, G. Sellge, A. Lorentz, W. Sebald, R. Raab, and M. P. Manns
Antigen-specific modulation of experimental 8086-8091 myasthenia gravis: Nasal tolerization with recombinant fragments of the human acetylcholine receptor a-subunit
Dora Barchan, Miriam C. Souroujon, Sin-Hyeog Im, Carlo Antozzi, and Sara Fuchs
On the role of thymic epithelium vs. bone 8092-8097 marrow-derived cells in repertoire selection of T cells
Rolf M. Zinkernagel and Alana Althage
Control of separate pathogenic autoantibody 8098-8103 responses marks MHC gene contributions to murine lupus
Timothy J. Vyse, Richard K. Halterman, Stephen J. Rozzo, Shozo Izui, and Brian L. Kotzin
Dichotomy between naive and memory CD4+ T cell 8104-8109 responses to Fas engagement
J. Desbarats, T. Wade, W. F. Wade, and M. K. Newell
The mast cell tumor necrosis factor a response to 8110-8115 FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48
Ravi Malaviya, Zhimin Gao, Krishnan Thankavel, P. Anton van der Merwe, and Soman N. Abraham
Heterophile antibodies segregate in families and are 8116-8119 associated with protection from type 1 diabetes
Jin-Xiong She, Tamir M. Ellis, S. Brian Wilson, Clive H. Wasserfall, Michele Marron, Sharon Reimsneider, Sally C. Kent, David A. Hafler, Donna S. Neuberg, Andy Muir, Jack L. Strominger, and Mark A. Atkinson
MEDICAL SCIENCES
Megakaryocyte hyperplasia and enhanced 8120-8125 agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice
Wolfgang Hauser, Klaus-Peter Knobeloch, Martin Eigenthaler, Stepan Gambaryan, Veit Krenn, Jbrg Geiger, Margarita Glazova, Elvira Rohde, Ivan Horak, Ulrich Walter, and Michael Zimmer
Sustained ex vivo expansion of hematopoietic stem 8126-8131 cells mediated by thrombopoietin
Mayumi Yagi, Kindred A. Ritchie, Ewa Sitnicka, Carl Storey, Gerald J. Roth, and Stephen Bartelmez
Long-term survival and function of intrahepatic islet 8132-8137 allografts in rhesus monkeys treated with humanized anti-CD154
Norma S. Kenyon, Maria Chatzipetrou, Michele Masetti, Alessandra Ranuncoli, Maria Oliveira, Joseph L. Wagner, Allan D. Kirk, David M. Harlan, Linda C. Burkly, and Camillo Ricordi
Tissue factor is required for uterine hemostasis and 8138-8143 maintenance of the placental labyrinth during gestation
Jonathan Erlich, Graham C. N. Parry, Colleen Fearns, Martin Muller, Peter Carmeliet, Thomas Luther, and Nigel Mackman
Apoptosis in heart failure: Release of cytochrome c 8144-8149 from mitochondria and activation of caspase-3 in human cardiomyopathy
Jagat Narula, Pramod Pandey, Eloisa Arbustini, Nezam Haider, Navneet Narula, Frank D. Kolodgie, Barbara Dal Bello, Marc J. Semigran, Anna Bielsa-Masdeu, G. William Dec, Sara Israels, Manel Ballester, Renu Virmani, Satya Saxena, and Surender Kharbanda * See Commentary on page 7614
A potential mechanism underlying the increased 8150-8155 susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity
Julie L. Moran, David Siegel, and David Ross * See Commentary on page 7624
Osteopontin-deficient mice are resistant to 8156-8160 ovariectomy-induced bone resorption
Hiroyuki Yoshitake, Susan R. Rittling, David T. Denhardt, and Masaki Noda
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Contents Targeting tumor vasculature endothelial cells and 8161-8166 tumor cells for immunotherapy of human melanoma in a mouse xenograft model
Zhiwei Hu, Ying Sun, and Alan Garen
MICROBIOLOGY
HIV-1 Nef increases T cell activation in a 8167-8172 stimulus-dependent manner
Jeffrey A. Schrager and Jon W. Marsh
Secretin PulD: Association with pilot PulS, structure, 8173-8177 and ion-conducting channel formation
Nico Nouwen, Neil Ranson, Helen Saibil, Bettina Wolpensinger, Andreas Engel, Alexandre Ghazi, and Anthony P. Pugsley
Structural basis of chaperone self-capping in 8178-8183 P pilus biogenesis
Danielle L. Hung, Jerome S. Pinkner, Stefan D. Knight, and Scott J. Hultgren
A single amino acid substitution in the cyclin D 8184-8189 binding domain of the infected cell protein no. 0 abrogates the neuroinvasiveness of herpes simplex virus without affecting its ability to replicate
Charles Van Sant, Yasushi Kawaguchi, and Bernard Roizman
Discovery of virulence genes of Legionella 8190-8195 pneumophila by using signature tagged mutagenesis in a guinea pig pneumonia model
Paul H. Edelstein, Martha A. C. Edelstein, Futoshi Higa, and Stanley Falkow
NEUROBIOLOGY
Intracellular o-1 receptor modulates phospholipase C 8196-8199 and protein kinase C activities in the brainstem
M. P. Morin-Surun, T. Collin, M. Denavit-Saubi6, E.-E. Baulieu, and F. P. Monnet
Immediate thalamic sensory plasticity depends on 8200-8205 corticothalamic feedback
David J. Krupa, Asif A. Ghazanfar, and Miguel A. L. Nicolelis M See Commentary on page 7622
Synaptic depression creates a switch that controls the 8206-8211 frequency of an oscillatory circuit
Farzan Nadim, Yair Manor, Nancy Kopell, and Eve Marder
Chemokines and activated macrophages in HIV 8212-8216 gpl20-induced neuronal apoptosis
Marcus Kaul and Stuart A. Lipton
Macaque inferior temporal neurons are selective for 8217-8222 disparity-defined three-dimensional shapes
Peter Janssen, Rufin Vogels, and Guy A. Orban
Somatic stiffness of cochlear outer hair cells is 8223-8228 voltage-dependent
David Z. Z. He and Peter Dallos
Structure of tau exon 10 splicing regulatory element 8229-8234 RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17
Luca Varani, Masato Hasegawa, Maria Grazia Spillantini, Michael J. Smith, Jill R. Murrell, Bernardino Ghetti, Aaron Klug, Michel Goedert, and Gabriele Varani
Determination of the rate of the glutamate/glutamine 8235-8240 cycle in the human brain by in vivo 13C NMR
Jun Shen, Kitt F. Petersen, Kevin L. Behar, Peter Brown, Terrence W. Nixon, Graeme F. Mason, Ognen A. C. Petroff, Gerald I. Shulman, Robert G. Shulman, and Douglas L. Rothman
Estrogen-inducible, sex-specific expression of 8241-8246 brain-derived neurotrophic factor mRNA in a forebrain song control nucleus of the juvenile zebra finch
Falk Dittrich, Yu Feng, Reinhold Metzdorf, and Manfred Gahr
PHARMACOLOGY
Local and systemic delivery of a stable 8247-8252 aspirin-triggered lipoxin prevents neutrophil recruitment in vivo
Clary B. Clish, Jennifer A. O'Brien, Karsten Gronert, Gregory L. Stahl, Nicos A. Petasis, and Charles N. Serhan
PHYSIOLOGY
Calcitonin is a major regulator for the expression of 8253-8258 renal 25-hydroxyvitamin D3-la-hydroxylase gene in normocalcemic rats
Toshimasa Shinki, Yutaka Ueno, Hector F. DeLuca, and Tatsuo Suda
Intracellular Ca2+ oscillations drive spontaneous 8259-8264 contractions in cardiomyocytes during early development
S. Viatchenko-Karpinski, B. K. Fleischmann, Q. Liu, H. Sauer, 0. Gryshchenko, G. J. Ji, and J. Hescheler
PLANT BIOLOGY
High gene density is conserved at syntenic loci of 8265-8270 small and large grass genomes
Catherine Feuillet and Beat Keller
The alternative oxidase lowers mitochondrial reactive 8271-8276 oxygen production in plant cells
Denis P. Maxwell, Yong Wang, and Lee McIntosh
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Regulation of thylakoid protein phosphorylation at 8277-8282 the substrate level: Reversible light-induced conformational changes expose the phosphorylation site of the light-harvesting complex II
Hagit Zer, Martin Vink, Nir Keren, Hans G. Dilly-Hartwig, Harald Paulsen, Reinhold G. Herrmann, Bertil Andersson, and Itzhak Ohad
PSYCHOLOGY
Stress-induced behaviors require the 8283-8288 corticotropin-releasing hormone (CRH) receptor, but not CRH
Stacie C. Weninger, Adrian J. Dunn, Louis J. Muglia, Pieter Dikkes, Klaus A. Miczek, Artur H. Swiergiel, Craig W. Berridge, and Joseph A. Majzoub
The mechanism of isoluminant chromatic 8289-8294 motion perception
Zhong-Lin Lu, Luis A. Lesmes, and George Sperling * See Commentary on page 7611
Social Sciences
POLITICAL SCIENCES
Committee proposals and restrictive rules 8295-8300 Jeffrey S. Banks
PSYCHOLOGY
Right hemispheric dominance of inhibitory control: 8301-8306 An event-related functional MRI study
H. Garavan, T. J. Ross, and E. A. Stein
CORRECTIONS AND RETRACTION
GENETICS Conservation of sequence and structure flanking the 8307 mouse and human P-globin loci: The 3-globin genes are embedded within an array of odorant receptor genes
Michael Bulger, J. Hikke von Doorninck, Noriko Saitoh, Agnes Telling, Catherine Farrell, M. A. Bender, Gary Felsenfeld, Richard Axel, and Mark Groudine
NEUROBIOLOGY The effect of dynamic synapses on spatiotemporal 8307 receptive fields in visual cortex
Omer B. Artun, Harel Z. Shouval, and Leon N. Cooper
Fluctuations and stimulus-induced changes in blood 8307 flow observed in individual capillaries in layers 2 through 4 of rat neocortex
David Kleinfeld, Partha P. Mitra, Fritjof Helmchen, and Winfried Denk
PLANT BIOLOGY Convergent pathways for lipochitooligosaccharide and 8307 auxin signaling in tobacco cells
Horst Rohrig, Jiirgen Schmidt, Richard Walden, Inge Czaja, Helge Lubenow, Ursula Wieneke, Jeff Schell, and Michael John
AUTHOR INDEX xi-xiii
INFORMATION FOR AUTHORS xiv-xvi
SIZING WORKSHEET xvii
DOCUMENTATION REPORT xviii
COPYRIGHT ASSIGNMENT FORM xix
CLASSIFIED ADVERTISEMENTS xx-xxi
Cover photograph: Functional connections within the somato-sensory system of the brain are not hardwired, as illustrated by the sub-cortical (thalamic) brain plasticity that follows (within minutes) a peripheral deafferentation. This plasticity, in turn, depends upon both ascending sensory inputs as well as descending cortical feedback projections. The left and right-most 3-D surface plots (cover) represent the response of a population of 24 thalamic neurons to the same tactile stimulus administered minutes before (left) and after (right) the skin around the stimulus site was anesthetized (during cortical inactivation). The reorganization (shifts from blue to red represent increased neuronal activity) which is seen in the absence of cortical feedback (compare left and right graphs) show that cortical inactivation during a peripheral deafferentation significantly reduced, but did not eliminate, immediate thalamic plasticity. (Image courtesy of Krupa et al. See article on pages 8200-8205 in this issue.)
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