Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 74, No. 11 (Nov., 1977), pp. vii-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/67450 .

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NOVEMBER 1977

Volume 74

Number 1 I

OF

Proceedings OF THE

National Academy

OF THE UNITED STATES OF AMERICA

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THE PROCEEDINGS OF THE

National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers of the Academy

PHILIP HANDLER President SAUNDERS MAC LANE Vice President DAVID R. GODDARD Home Secretary GEORGE S. HAMMOND Foreign Secretary E. R. PIORE Treasurer

Editorial Board of the Proceedings

ROBERT L. SINSHEIMER Chairman ROBERT M. SOLOW Vice Chairman HARRISON SHULL Vice Chairman DAVID R. GODDARD Home Secretary GEORGE S. HAMMOND Foreign Secretary E. R. PIORE Treasurer

ALEXANDER G. BEARN S. M. LIPSET P. D. BOYER MACLYN MCCARTY HARRY EAGLE EUGENE P. ODUM HERMAN EISEN ALEXANDER RICH RICHARD M. HELD E. R. STADTMAN MARTIN D. KAMEN ELIAS M. STEIN HENRY S. KAPLAN HOWARD M. TEMIN SEYMOUR S. KETY JAMES TOBIN

Managing Editor: BERNARD K. FORSCHER Associate Editor: GARY T. COCKS Associate Editor: MURRIE W. BURGAN

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AUTHOR INDEX, NOVEMBER 1977

Achtman, M. 5104 Adler, J. 4964 Adolph, K. W. 4937 Arceci, R. J. 5016 Armour, R. 5046 Avise, J. C. 5083 Axel, R. 4867 Baglioni, C. 5198 Baldwin, J. H. 5046 Barchas, J. D. 5155 Barker, J. E. 5078 Benacerraf, B. 5118 Berg, D. K. 5171 Bergeron, J. J. M. 5051 Berissi, H. 4801 Bertin, G. 4726 Bina-Stein, M. 5198 Bishayee, S. 4891 Bloch, K. 4924 Bloom, F. E. 5162 Blume, A. J. 4927 Botstein, D. 5091 Bourguignon, L. Y. W.

5031 Browder, F. E. 4749 Brown, K. D. 5046 Brown, M. 4796 Carmichael, G. G. 4835 Carver, J. P. 5056 Cazenave, P.-A. 5122 Cecka, J. M. 5135 Chakraborty, P. R. 4891 Chan, H. 4914 Chance, B. 4777 Chang, J. C. 5145 Chang, S. 4811 Chen, K. 5109 Chen, R. 4905 Cheng, S. M. 4937 Chen-Schmeisser, U.

4905 Cohen, S. N. 4811 Cohn, Z. A. 4895 Cole, R. D. 4852 Collignon, C. 5126 Costa, J. 5060 Cozzarelli, N. R. 4767 Crane, H. R. 4744 Criddle, R. S. 4919 Cuatrecasas, P. 4881 Dasgupta, R. 4900 Datta, P. 4862 Davies, D. R. 5140 Del Valle, L. A. 5159 De Mello, F. G. 4977 Donovan, C. M. 5113 Dorf, M. E. 5118 Draper, D. E. 4786 Edelstein, C. 5001 England, T. E. 4839 Epstein, C. C. 4862 Ericsson, L. H. 4762 Ethier, S. N. 5096 Evans, F. E. 4909 Eyring, H. 4739 Farquhar, M. G. 5073 Feigelson, P. 4791 Finberg, J. P. M. 4927 Fischer, E. H. 4762 Fisher, W. R. 5150 Fletterick, R. J. 4757 Flippen, J. L. 4730 Ford, J. 4982 Foster, S. J. 4816 Fox, G. E. 5088 Franssen, J. D. 5126

Frelinger, J. A. 5131 Garel, A. 4867 Garen, A. 5099 Gegenbach, B. G. 5113 Gellert, M. 4772 Gilbert, W. 4973 Gill, G. N. 4843 Glover, D. M. 4932 Goodman, M. F. 4806 Gore, W. C. 4806 Gorin, F. A. 5179 Gotto, A. M., Jr. 48483 Goy, M. F. 4964 Graessmann, A. 4831 Graessmann, M. 4831 Green, C. E. 5113 Greene, L. A. 5021 Greene, M. I. 5118 Gross, P. R. 5016 Guillemin, R. 5162 Gumport, R. I. 4839 Hamill, A. L. 4895 Helene, C. 4872 Herbert, E. 4826 Hermann, J. 4762 Herrera, I. 4722 Herz, R. 5036 Herzog, V. 5073 Hickey, E. D. 5198 Highsmith, S. 4986 Hino, T. 4730 Hirsch, J. 5193 Hogness, D. S. 5041 Holley, R. W. 5046 Hood, L. 5135 Hopkins, R. 4806 Hsiang, M. W. 4852 Hsu, M.-T. 4982 Hu, S. S. F. 4781 Hunston, D. L. 4959 Hwang, K. J. 4991 Itoh, T. 4772 Jackson, R. L. 4848 Jameson, J. L. 4881 Jhon, M. S. 4739 Johnston, R. 4919 Jones, B. B. 4914 Kaesberg, P. 4900 Kaiser-Kupfer, M. I.

5159 Kamiryo, T. 4947 Kan, Y. W. 5145 Kaplan, N. 0. 4909 Karle, J. 4707 Kasvinsky, P. J. 4757 Kaufmann, S. H. 4876 Kaufmann, Y. 4801 Kauvar, L. 5099 Kefauver, B. C. 5078 Kennedy, N. 5104 Khoo, J. C. 4843 Khoury, G. 4796 Kilgore, L. L. 5150 Kinnunen, P. K. J. 4848 Kirsten, E. 4942 Klier, F. G. 5184 Klotz, I. M. 4959 Kodato, S. 4730 K-oide, A. 4762 Kopriwa, B. 5051 Koshland, D. E., Jr.

4752 Kretzschmar, K. M.

4986 Kreuzer, K. N. 4767 Kumar, S. 4762

Kun, E. 4942 Kurtz, D. T. 4791 Kuster, J. M. 4796 Laemmli, U. K. 4937 Lai, M. M. C. 4781 Lala, A. K. 4924 Lancelot, G. 4872 Lane, M. D. 4876 Lau, Y. Y. 4726 Lee, V. 5021 Leigh, J. S., Jr. 4777 Leive, L. 5065 Lepesant, J.-A. 5099 Levine, G. 5051 Li, C. H. 5155 Liebman, M. 4821 Lin, C. C. 4726 Lin, H.-K. 4924 Lin, P.-S. 5069 Ling, N. 5162 McDevitt, H. 0. 5135 MacDonald, E. 4881 McGuire, T. R. 5193 Mackall, J. C. 4876 McMaster, G. K. 4835 McMillan, M. 5135 Madsen, N. B. 4757 Mahoney, E. M. 4895 Maitra, U. 4891 Majumder, H. K. 4891 Marciani, D. J. 4951 Mark, J. W.-K. 4726 Marshall, G. R. 5179 Martin, R. B. 4924 Mauk, M. R. 4991 Medici, N. 4886 Mergenhagen, S. E. 4955 Milcarek, C. 4801 Miller, J. B. 4752 Minick, S. 5162 Mishina, M. 4947 Mizuuchi, K. 4772 Mohri, H. 5006 Mohri, T. 5006 Molinari, A. M. 4886 Moncharmont, B. 4886 Mora, P. T. 4796 Morales, M. F. 4986 Mueller, C. 4831 Murphy, D. B. 5135 Nadler, N. J. 5051 Nakagawa, M. 4730 Nath, A. 4996 Navia, M. A. 5140 Neumann, K. H. 5145 Neurath, H. 4762 Neyman, J. 4714 Nienhuis, A. W. 5078 Nirenberg, M. 4977 Nishi, R. 5171 Norman, M. F. 5096 Numa, S. 4947 Nuss, D. L. 5198 O'Dea, M. H. 4772 Ogata, R. 4973 Ogawa, K. 5006 Oh, Y. 4739 Ohtsuki, M. 5001 Okajima, H. 4730 O'Konski, C. T. 4986 Olsen, C. E. 4955 O'Shaughnessy, D. 5051 Papas, T. S. 4951 Patel, D. J. 4734 Paterson, B. M. 4951 Paulson, J. R. 4937

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AUTHOR INDEX, NOVEMBER 1977

Peebles, C. L. 4767 Penman, S. 4801 Perkins, J. P. 4816 Petes, T. D. 5091 Pierce, J. E. 5078 lPierres, M. 5118 Poon, R. 5145 Posner, B. I. 5051 Pratt, C. W. 4786 Prives, J. M. 5166 Puca, C. A. 4886 Puro, D. G. 4977 Rabson, A. S. 5060 Rambach, A. 5041 Reed, B. C. 4876 Reis, B. L. 5131 Reznikoff, W. S. 4914 Richert, N. D. 4857 Roberts, J. L. 4826 Rtosenheck, K. 5036 Rossier, J. 5162 Rothstein, S. 4914 Rubin, H. 5026 Rubin, J. 4821 Rubinstein, M. 4969 Russell, W. A. 5131 Ryan, R. J. 4857 Samuelson, P. A. 5189 Sandberg, A. L. 4955 Sandoval, I. V. 4881 Sanui, H. 5026 Scanu, A. M. 5001 Schmidt-Ullrich, R.

5069

Schneider, A. S. 5036 Schubert, D. 5184 Scott, W. A. 4895 Sharma, M. L. 4942 Shelanski, M. L. 5021 Shen, C. 4734 Shireman, R. 5150 Shorr, 4927 Sikstrom, R. 5051 Silver, J. 5131 Silverton, E. W. 5140 Simpson, R. T. 5198 Singer, S. J. 5031 Skurray, R. 5104 Smith, H. H. 5109 Smith, L. C. 4848 Sogard, M. 5001 Sparrow, J. T. 4848 Spector, I. 5166 Spector, S. 4927 Sperry, P. J. 4843 Springer, M. S. 4964 Srivastava, T. S. 4996 Stanley, P. 5056 Stein, A. 5198 Stein, S. 4969 Steinberg, D. 4843 Stern, R. 5060 Student, A. K. 4876 Sugino, A. 4767 Sugiyama, L. 4726 Sundaralingam, M. 4821 Sygusch, J. 4757 Tamm, I. 5011

Tashiro, S. 4947 Temple, G. F. 5145 Thompson, W. S. 5069 Titani, K. 4762 Tomizawa, J. 4772 Tralka, T. S. 5060 Tyagi, S. 4996 Udenfriend, S. 4969 Uhlenbeck, 0. C. 4839 Urbain, J. 5126 Valle, D. 5159 Vargo, T. M. 5162 Vogt, P. K. 4781 von der Malsburg, C.

5176 von Hippel, P. H. 4786 Wade, R. D. 4762 Wahl, L. M. 4955 Wallach, D. F. H. 5069 Walsh, K. A. 4762 Watanabe, H. 4730 Watson, S. J. 5155 Weber, L. A. 5198 Wells, R. D. 4914 Wikler, M. 5126 Wilczek, J. 5060 Wildman, S. G. 5109 Willshaw, D. J. 5176 Witkop, B. 4730 Woese, C. R. 5088 Yeagle, P. L. 4924 Yeh, Y.-C. 5046 Zolan, M. 4867

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Contents (Continued from page x)

POPULATION Generalizing Fisher's "reproductive value": Linear differential and difference equations of "dilute" biological BIOLOGY systems (one-sex demographyleigenvectors/density dependence/asymptotic importance) .

.......................................................................... P aul A. Samuelson 5189-5192

PSYCHOLOGY Behavior-genetic analysis of Phormia regina: Conditioning, reliable individual differences, and selection (classical conditioning/Dipteran learning/replication study/test reliability/proboscis reflex).

........................................................... T e rry R. McGuire and Jerry Hirsch 5193-5197

Corrections

BIOCHEMISTRY Crosslinked histone octamer as a model of the nucleosome core (chromatin/superhelical DNA/DNA flexibility) . ........................................ Arnold Stein, Minou Bina-Stein, and Robert T. Simpson 5198

5'-Terminal 7-methylguanosine and mRNA function: Influence of potassium concentration on translation in vitro (vaccinia mRNA/unmethylated mRNA/wheat germ/reticulocyte lysate) ....................

. ........................... Lee A. Weber, Eileen D. Hickey, Donald L. Nuss, and Corrado Baglioni 5198

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Contents (Continued from page xi)

GENETICS Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast (ribosomal RNA genes/tetrad anal- ysis/meiotic recombination/mitotic recombination/restriction endonuclease EcoRI).

.......................................................... Thomas D. Petes and David Botstein 5091-5095 Error estimate for the diffusion approximation of the Wright-Fisher model (population genetics/stochastic

processes/random genetic drift) ............................... S. N. Ethier and M. Frank Norman 5096-5098 Roles of ecdysone in Drosophila development (steroid hormone/temperature-sensitive mutants) ........

...................................... .Alan Garen, Lawrence Kauvar, and Jean-Antoine Lepesant 5099-5103 Cell-cell interactions in conjugating Escherichia coli: Role of traT protein in surface exclusion (chimeric

plasmid/in vitro protein synthesis/regulation/outer membrane/sex factor protein) .................. ............................................ .Mark Achtman, Nicholas Kennedy, and Ron Skurray 5104-5108

Chloroplast DNA distribution in parasexual hybrids as shown by polypeptide composition of fraction I protein (organelle DNA/ribulose-1,5-bisphosphate carboxylase/cytoplasmic inheritance/protoplast fusion) .... . .............................................. Kevin Chen, S. G. Wildman, and Harold H. Smith 5109-5112

Inheritance of selected pathotoxin resistance in maize plants regenerated from cell cultures (cell culture se- lection/plant regeneration/disease resistance/Helminthosporium maydis race T/cytoplasmic inheritance) .............................................. .B. G. Gengenbach, C. E. Green, and C. M. Donovan 5113-5117

IMMUNOLOGY Reduction of syngeneic tumor growth by an anti-I-J alloantiserum (tumor growth/H-2 complex/I region) ............................. .Mark I. Greene, Martin E. Dorf, Michel Pierres, and Baruj Benacerraf 5118-5121

Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits (anti-ribonuclease antibodies/idiotypic repertoire/network hypothesis) ........................ P.-A. Cazenave 5122-5125

Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies (immunoregulation/idiotypic networks/anti-anti-.idiotypic antibodies) ............................ . .......................................... J. Urbain, M. Wikler, J. D. Franssen, and C. Collignon 5126-5130

Chemical characterization of murine Ia alloantigens determined by the I-E/I-C subregions of the H-2 complex (immunoprecipitation/two polypeptides/NH2-ter minal sequencing/sequence homology) ............. ........................... .Jack Silver, William A. Russell, Brenda L. Reis, and Jeffrey A. Frelinger 5131-5134

Structure of murine Ia antigens: Partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion (H-2 complex gene products/immunoprecipitation/microsequence analysis/sequence homology)

. ......... Minnie McMillan, J. Michael Cecka, Donal B. Murphy, Hugh 0. McDevitt, and Leroy Hood 5135-5139 Three-dimensional structure of an intact human immunoglobulin (antibodies/x-ray diffraction/glycopro-

tein/carbohydrate) ............ E. W. Silverton, Manuel A. Navia, and David R. Davies 5140-5144

MEDICAL The nucleotide sequences of the untranslated 5' regions of human a- and f-globin mRNAs (cDNA/restriction SCIENCES endonuclease).

.............. .Judy C. Chang, Gary F. Temple, Raymond Poon, Kurt H. Neumann, and Yuet Wai Kan 5145-5149 Solubilization of apolipoprotein B and its specific binding by the cellular receptor for low density lipoprotein

(fibroblast/lymphocyte/hyper-f-lipoproteinemia/LDL degradation/apolipoprotein B-bovine serum albumin complex) .......... Rachel Shireman, Laura L. Kilgore, and Waldo R. Fisher 5150-5154

f-Lipotropin: Localization of cells and axons in rat brain by immunocytochemistry (opiate peptides/endor- phin/corticotropin/anatomy) ................. Stanley J. Watson, Jack D. Barchas, and Choh Hao Li 5155-5158

Gyrate atrophy of the choroid and retina: Deficiency of ornithine aminotransferase in transformed lymphocytes (chorioretinal degeneration/urea cycle/polyamines) ............................................. ...................................... .Davidi Valle, Muriel I. Kaiser-Kupfer, and Luis A. Del Valle 5159-5161

NEUROBIOLOGY Regional dissociation of f-endorphin and enkephalin contents in rat brain and pituitary (opiates/radioim- munoassay/neurotransmitter/adrenalectomy and hypophysectomy/myelin basic protein). . .. Jean Rossier, Theresa M. Vargo, Scott Minick, Nicholas Ling, Floyd E. Bloom, and Roger Guillemin 5162-5165

Development of electrophysiological and biochemical membrane properties during differentiation of embryonic skeletal muscle in culture (resting potential/electrical excitability/acetylcholine receptor/acetylcholines- terase) .. Ilan Spector and Joav M. Prives 5166-5170

Dissociated ciliary ganglion neurons in vitro: Survival and synapse formation (neuron-myotube cell cul- ture/development/parasympathetic/neuronal cell death/neuromuscular junction) .................. ................................................................ Rae Nishi and Darwin K. Berg 5171-5175

How to label nerve cells so that they can interconnect in an ordered fashion (ontogenesis/retinotopy/neural plasticity/induction of markers) ................ Ch. von der Malsburg and D. J. Willshaw .................5176-5178

Proposal for the biologically active conformation of opiates and enkephalin (opiate receptor/neuroblastoma X glioma/morphi ne/x-ray crystallography) ................ Fredric A. Gorin and Garland R. Marshall .................5179-5183

Storage and release of acetylcholine by a clonal cell line (dense-core vesicle/sympathetic neuron).....

(Continued on page ix)

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Contents (Continued from page xii)

5'-Terminal 7-methylguanosine and mRNA function: Influence of potassium concentration on translation in vitro (Correction) (vaccinia mRNA/unmethylated mRNA/wheat germ/reticulocyte lysate) .........

. ........................... Lee A. Weber, Eileen D. Hickey, Donald L. Nuss, and Corrado Baglioni 5198

BIOPHYSICS Flexibility of myosin rod, light meromyosin, and myosin subfragment-2 in solution (myosin fragments/protein dynamics/electro-optics/muscle). ...................... .Stefan Highsmith, K. M. Kretzschmar, C. T. O'Konski, and Manuel F. Morales 4986-4990

Fate of lipid vesicles in vivo: A gamma-ray perturbed angular correlation study (liposomes/drug-delivery system/rotational correlation time/gamma-ray probe) ........... Karl J. Hwang and Marcia R. Mauk 4991-4995

Emission M6ssbauer study of the stereochemical trigger that initiates cooperative interaction of hemoglobin subunits ([57Co]cobaltohemoglobin/heme pocket/Auger ionization) ................................

..................................................... T. S. Srivastava, S. Tyagi, and Amar Nath 4996-5000 Electron microscopy of negatively stained and freeze-etched high density lipoprotein-3 from human serum

(phase contrast effects/conventional transmission electron microscope/scanning transmission electron microscope) ....... Mitsuo Ohtsuki, Celina Edelstein, Michael Sogard, and Angelo M. Scanu 5001-5005

CELL BIOLOGY Identification of dynein as the outer arms of sea urchin sperm axonemes (flagellaladenosinetriphosphatase/ motility/immunoelectron microscopy) ............... Kazuo Ogawa, Toshiko Mohri, and Hideo Mohri 5006-5010

Definition of subclasses of nucleoplasmic RNA (nuclear RNA-synthesizing system/HeLa cells/5,6-dichloro- 1-j3-D-ribofuranosylbenzimidazole/a-amanitin/heparin) ............................... Igor Tamm 5011-5015

Noncoincidence of histone and DNA synthesis in cleavage cycles of early development (sea urchin embryos/lell cycle/protein synthesis) ............................................. R. J. Arceci and P. R. Gross 5016-5020

Specific neural and adrenal medullary antigens detected by antisera to clonal PC12 pheochromocytoma cells (nerve growth factor/cell surface antigens/cell culture/immunology) ............................... . ........................................ Virginia Lee, Michael L. Shelanski, and Lloyd A. Greene 5021-5025

Complexes of inorganic pyrophosphate, orthophosphate, and calcium as stimulants of 3T3 cell multiplication (growth stimulation/divalent cations) ................................... H. Rubin and H. Sanui 5026-5030

Transmembrane interactions and the mechanism of capping of surface receptors by their specific ligands (non-muscle-cell myosin and actin/T lymphoc9tes/HeLa cells/sliding filament mechanism) .......... ... .................................................... Lilly Y. W. Bourguignon and S. J. Singer 5031-5035

Stimulus-secretion coupling in chromaffin cells isolated from bovine adrenal medulla (catecholamine secre- tion/acetylcholine receptors/K+ depolarization/calcium requirement/microtubule disruption) ....... ............................................... Allan S. Schneider, Ruth Herz, and Kurt Rosenheck 5036-5040

Translation of Drosophila melanogaster sequences in Escherichia coli (recombinant DNA/plasmids/protein synthesis/minicells/gel electrophoresis) ...................... Alain Rambach and David S. Hogness 5041-5045

Density-dependent regulation of growth of BSC-1 cells in cell culture: Control of growth by serum factors (epidermal growth factor/epithelial cells/initiation of DNA synthesis/mitogen receptors/wound healing experiment) ............................................................................... ......... .Robert W. Holley, Rosemary Armour, Julia H. Baldwin, Kenneth D. Brown, and Yun-Chi Yeh 5046-5050

Polypeptide hormone binding sites in vivo: Initial localization of 125I-labeled insulin to hepatocyte plasmalemma as visualized by electron microscope radioautography (liver insulin receptor/endothelium) ........... ....................................................................... I.. J. J. M. Bergeron, . .............. G. Levine, R. Sikstrom, D. O'Shaughnessy, B. Kopriwa, N. J. Nadler, and B. I. Posner 5051-5055

Selective loss of wheat germ agglutinin binding to agglutinin-resistant mutants of Chinese hamster ovary cells (cell surface/Scatchard plots/positive cooperativity) ........... Pamela Stanley and Jeremy P. Carver 5056-5059

Hexamethylene bisacetamide induces morphologic changes and increased synthesis of procollagen in cell line from glioblastoma multiforme (cell differentiation/collagen synthesis) ............................. ..... . . ........... Alan S. Rabson, Robert Stern, Tommie S. Tralka, Jose Costa, and Joseph Wilczek 5060-5064

Domains involving nonrandom distribution of lipopolysaccharide in the outer membrane of Escherichia coli (membrane heterogeneity/mutant lacking galactose epimerase) ....................... Loretta Leive 5065-5068

Simian virus 40-specific proteins in the membranes of simian virus 40-transformed hamster and mouse cells (isoelectric focusing-immune electrophoresis/isoelectric focusing-dodecyl sulfate polyacrylamide gel electrophoresis/S-antigen/U-antigen) .................................................... . .............. Rupert Schmidt-Ullrich, W. Scott Thompson, Peck-Sun Lin, and Donald F. H. Wallach 5069-5072

Luminal membrane retrieved after exocytosis reaches most Golgi cisternae in secretory cells [membrane recycling/dextran/parotid/lacrimal (gland)] ................ Volker Herzog and Marilyn G. Farquhar 5073-5077

Hemoglobin switching in sheep and goats: Induction of hemoglobin C synthesis in cultures of sheep fetal erythroid cells (sheep ontogeny/globin synthesis/globin genes/erythropoietin) ...................... .................... .Jane E. Barker, Joseph E. Pierce, Bernard C. Kefauver, and Arthur W. Nienhuis 5078-5082

EVOLUTION Is evolution gradual or rectangular? Evidence from living fishes (speciation/paleobiology/isozymes/evolu- tionary rates) .................... ............ .........John C. Avise 5083-5087

Phylogenetic structure of the prokiaryotic domain: The primary kingdoms (archaebacteria/eubacteria/ur- karyote/16S ribosomal RNA/molecular phylogeny) .C...................arl R. Woese and George E. Fox .............5088-5090

(Conztinued on page x)

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Contents (Continued from inside back cover)

Role of nucleotides in tubulin polymerization: Effect of guanylyl 5'-methylenediphosphonate (microtu- bules/guanosine nucleotides/high molecular weight basic proteins/calcium/electron microscopy) .......

. .................. Ignacio V. Sandoval, Eve MacDonald, James L. Jameson, and Pedro Cuatrecasas 4881-4885 Estradiol receptor of calf uterus: Interaction with heparin-agarose and purification (affinity chromatogra-

phy/nuclear receptor/receptor- transforming factor/sodium dodecyl sulfate-polyacrylamide gel electro- phoresis) ..... Anna Maria Molinari, Nicola Medici, Bruno Moncharmont, and Giovanni Alfredo Puca 4886-4890

Ribonuclease III cleavage of bacteriophage T3 RNA polymerase transcripts to late T3 mRNAs (RNA pro- cessing/specific T3 promoters/RNA nucleotidyltransferase) ......................................

. ............ Hemanta K. Majumder, Subal Bishayee, Prasanta R. Chakraborty, and Umadas Maitra 4891-4894 Response of endocytosis to altered fatty acyl composition of macrophage phospholipids (membrane fluidity/

pinocytosis/phagocytosis/activation energy) ................................................... ......................... .Eileen M. Mahoney, Anne L. Hamill, William A. Scott, and Zanvil A. Cohn 4895-4899

Sequence of an oligonucleotide derived from the 3' encl of each of the four brome mosaic viral RNAs (amino- cacylation/tRNA-like structure) ............................... Ranjit Dasgupta and Paul Kaesberg 4900-4904

Isopeptide linkage between N-ce-monomethylalanine and lysine in ribosomal protein Sli from Escherichia coli (ribosome structure/protein modification/dansyl amino acids/solid-state peptide synthesis).......

...................................................... Robert Chen and Ursula Chen-Schmeisser 4905-4908 31P nuclear magnetic resonance studies of HeLa cells (human astrocytoma/acid-soluble phosphates/metabolic

inhibitors) ........................................... Frederick E. Evans and Nathan 0. Kaplan 4909-4913 RNA polymerase binding sites in XplacS DNA (bacteriophage X/RNA nucleotidyltransferase/promoters)

......... .Barbara B. Jones, Hardy Chan, Steven Rothstein, Robert D. Wells, and William S. Reznikoff 4914-4918 F1-ATPase-catalyzed synthesis of ATP from oleoylphosphate and ADP (mitochondria/adenosine triphosphate)

...................................................... Richard Johnston and Richard S. Criddle 4919-4923 Differential effects of cholesterol and lanosterol on artificial membranes (glucose permeability/13C nuclear

magnetic resonance spectroscopy) ............................................................ ................ .Philip L. Yeagle, R. Bruce Martin, Anil K. Lala, Hung-Kuang Lin, and Konrad Bloch 4924-4926

Binding of the endogenous nonpeptide morphine-like compound to opiate receptors (morphine antibodies/ neuroblastoma X glioma hybrid cell line) ....................................................... ............................ Arthur J. Blume, Jeoshua Shorr, John P. M. Finberg, and Sydney Spector 4927-4931

Cloned segment of Drosophila melanogaster rDNA containing new types of sequence insertion (DNA*RNA hybridization/R-loops/heteroduplexes/restriction endonuclease sites/renaturation kinetics) .......... ............................................................................ David M. Glover 4932-4936

Isolation of a protein scaffold from mitotic HeLa cell chromosomes (metaphase/nonhistones/DNA super- structure/micrococcal nuclease/dextran sulfate) ................................................

. ................................... K. W. Adolph, S. M. Cheng, J. R. Paulson, and U. K. Laemmli 4937-4941 Enzymatic formation of glutathione-citryl thioester by a mitochondrial system and its inhibition by

(-)erythrofluorocitrate (glutathione-S-citryl ester/metalloprotein/inner mitochondrial membrane/fluo- rocitrate toxic mechanism) ...... ................. Ernest Kun, Eva Kirsten, and Manohar L. Sharma 4942-4946

Candida lipolytica mutants defective in an acyl-coenzyme A synthetase: Isolation and fatty acid metabolism (cerulenin/composition of cellular fatty acids/Schmidt reaction/single-cell protein) .................. .................... .Tatsuyuki Kamiryo, Masayoshi Mishina, Shin-ichi Tashiro, and Shosaku Numa 4947-4950

Cell-free synthesis of the precursor polypeptide for avian myeloblastosis virus DNA polymerase (group-specific antigen/DNA nucleotidyltransferase/polyprotein/genetic map/enzyme processing) .................. . ...................................... Bruce M. Paterson, Dante J. Marciani, and Takis S. Papas 4951-4954

Prostaglandin regulation of macrophage collagenase production (endotoxin/macrophage activation/prosta- glandin synthesis/connective tissue) .......................................................... . .................. Larry M. Wahl, Charles E. Olsen, Ann L. Sandberg, and Stephan E. Mergenhagen 4955-4958

Analytical and graphical examination of strong binding by half-of-sites in proteins: Illustration with aspartate transcarbamylase (binding constants/affinity profiles/ligand affinities/interactions between sites) ..... ........................................................ .Irving M. Klotz and Donald L. Hunston 4959-4963

Sensory transduction in Escherichia coli: Role of a protein methylation reaction in sensory adaptation (bacterial chemotaxis/protein modification/electrophoresis) .............................................. . ............................................ Michael F. Goy, Martin S. Springer, and Julius Adler 4964-4968

Isolation and characterization of the opioid peptides from rat pituitary: 3-Endorphin (fluorescence/high- performance liquid chromatography/peptide maps) ............................................. .................................... .Menachem Rubinstein, Stanley Stein, and Sidney Udenfriend 4969-4972

Contacts between the lac repressor and thymines in the lac operator (E. coli genetic control/bromodeoxyuridine substitution/ultraviolet light crosslinking/DNA sequencing) ......... Ronald Ogata and Walter Gilbert 4973-4976

Synapse turnover: The formation and termination of transient synapses (adhesion of cells/synapse selec- tion/retina cells/myotubes/cell culture) ........................................................ .................. ..............Donald G. Puro, Fernando G. De Mello, and Marshall Nirenberg ........................ 4977-4981

Sequence arrangement of the 5' ends of simian virus 40 16S and 19S mRNAs (electron microscopy/RNA.DNA hybrid ization) ...............Ming- Ta Hsu and John Ford ........................ 4982-4985

Crosslinked histone octamer as a model of the nucleosome core (Correction) (chromatin/superhelical DNA/DNA flexibility) ...............Arnlold Stein, Minou Bina-Stein, and Robert T. Simpson ........................ 5198

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