Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 76, No. 3 (Mar., 1979), pp. v-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/69209 .

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MARCH 1979

VOLUME 76

NUMBER 3

OFOF THq

O ~ ~ t

-

OF THE UNITED STATES OF AMERICA

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Proceedings OF THE

National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers of the Academy

PHILIP HANDLER President SAUNDERS MAC LANE Vice President DAVID R. GODDARD Home Secretary THOMAS F. MALONE Foreign Secretary E. R. PIORE Treasurer

Editorial Board of the Proceedings

ROBERT L. SINSHEIMER Chairman HARRISON SHULL Vice Chairman DAVID R. GODDARD Home Secretary THOMAS F. MALONE Foreign Secretary E. R. PIORE Treasurer

K. FRANK AUSTEN JOHN R. BORCHERT P. D. BOYER JULIUS H. COMROE, JR. JOHN E. DOWLING HARRY EAGLE RICHARD M. HELD HENRY S. KAPLAN

DANIEL E. KOSHLAND, JR. S. M. LiUSET NEVIN S. SCRIMSHAW

E. R. STADTMAN ELIAS M. STEIN HOWARD M. TEMIN JAMES TOBIN CHARLES H. TOWNES

JAMES B. WYNGAARDEN

Managing Editor: BERNARD K. FORSCHER Associate Editor: GARY T. COCKS Associate Editor: MURRIE W. BURGAN Associate Editor: SHEILA L. ROSENTHAL Assistant Managing Editor: STEPHANIE G. PASSMAN

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? 1979 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.

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AUTHOR INDEX, MARCH 1979

Air, G. M. 1425 Allen, L. C. 1009 Aloe, L. 1246 Anderson, W. W. 1519 Antoniades, H. N. 1279 Appella, E. 141i Axel, R. 1373 Bacon, L. D. 1435 Bell, E. 1274 Bertolini, L. 1464 Bianchi, D. W. 1453 Bielinska, M. 1208 Black, B. 1395 Blobel, G. 1251 Boggs, R. T. 1233 Boime, 1. 1208 Bol, J. F. 1114 Bologna, M. 1256 Boublik, M. 1054 Bowen-Pope, D. F. 1308 Boynton, J. E. 1353 Brownstein, M. J. 1448 Brunso-Bechtold, J. K.

1494 Brunton, L. L. 1472 Brutlag, D. 1524 Burch, J. B. E. 1030 Burkhart-Schultz, K. J.

1382 Burton, W. G. 1390 Callaham, M. F. 1293 Cann, H. M. 1453 Capone, G. T. 1279 Carlson, M. 1524 Carrano, A. V. 1382 Cashman, J. S. 1169 Chang, C. N. 1251 Chan-Palay, V. 1485 Chasin, L. 1373 Chyn, T. L. 1241 Clemetson, K. J. 1069 Clift, S. M. 1074 Cohn, D. V. 1469 Cohn, Z. A. 1400 Cooper, H. A. 1069 Cordell, B. 1348 Correa, F. M. A. 1489 Crawford, C. L. 1122 Crepeau, R. H. 1140 Crewe, A. V. 1228 Davis, R. W. 1035 Deanin, G. G. 1318 de la Rosa, M. E. 1519 Demain, A. L. 1343 Dodgson, J. B. 1348 Dorfinan, A. 1261 Draper, D. E. 1040 Dressler, D. 1084 Dubrow, R. 1298 Dulbecco, R. 1256 Dunn, M. J. 1155 Durack, D. T. 1443 Edelman, G. M. 1223 Edelstein, S. J. 1140 Edgell, M. H. 1385 Elad, D. 1089 Emmnons, S. W. 1333 Engel, J. D. 1348 Enquist, L. W. 1363 Erbe, R. W. 1313 Esser, A F. 1410 Essigmann, J. M. 1343 Eyring, H. 1018 Farley, B. A. 1477 Farquhar, M. G. 1303 Fenyo, E. M. 1405 Feussner, G. K. 1482

Frankel, M. E. 1425 Friedman, D. I. 1122 Friend, C. 1464 Fruton, J. S. 1131 Fujiwara, M. 1145 Futai, M. 1126 Gajdusek, D. C. 1524 Garrell, R. L. 1140 Gaso, M. I, 1519 Gatti, M. 1377 Gazdar, C. 1099 Gerhard, W. 1425 Gibbs, C. J., Jr. 1524 Gildersleeve, D. 1448 Gillham, N. W. 1353 Gordon, M. W. 1318 Grabowy, C. T. 1390 Gray, J. W. 1382 Groer, P. G. 1524 Gudas, L. J. 1074 Gundy, R. F. 1026 Gurd, F. R. N. 1059 Guzman, J. 1519 Hackenbrock, C. R. 1236 Hahn, L.-H. E. 1160 Haigwood, N. L. 1385 Hakomori, S. 1524 Hamburger, V. 1494 Harrington, W. F. 1109 Hass, P. E. 1164 Hassid, A. 1155 Hayaishi, 0. 1145 Heidelberger, C. 1456 Helinski, D. R. 1150 Henes, J. B. 1131 Herlyn, D. 1438 Herlyn, M. 1438 Herman, M. M. 1164 Hermans, J. 1189 Herzenberg, L. A. 1453 Hess, B. 1045 Higashida, H. 1135 Hill, T. L. 1014 Hirata, F. 1145 Hirsh, D. 1333 Hochli, M. 1236 Hoffman, R. M. 1313 Hong, J.-s. 1213 Hood, J. M. 1395 Hood, L. - 1395 Hu, S. S. F. 1265 Huberman, E. 1293 Hudspeth, A. J. 1506 Hughes, S. H. 1348 Hunt, A.G. 1213 Hutchison, C. A., III

1385 Innis, R. B. 1489 Invernizzi, G. 1415 Isaacson, M. S. 1228 Ito, K. 1199 Itoyama, Y. 1510 Ivarsson, B. 1274 Iverson, G. M. 1453 Jack, J. W. 1368 Jacobs, R. 1506 Jacobsen, S. J. 1313 Jaffe, L. F. 1328 Jagus, R. 1094 Jan, L. Y. 1501 Jan, Y. N. 1501 Jazwinski, S. M. 1223 Jones,, C. 1358 Judd,i B. H. 1368 Jurss, R. 1064 Kabat, E. A. 1420 Kahn, P. C. 1009

Kanazawa, H. 1126 Kanwar, Y. S. 1303 Kaplan, G. 1400 Karr, T. 1109 Katz, D. H. 1430 Keren-Zur, M. 1054 Klass, M. R. 1333 Klebanoff, S. J. 1443 Kolb, W. P. 1410 Kolter, R. 1150 Konieczkowski, M. 1155 Koper-Zwarthoff, E. C.

1114 Koprowski, H. 1438 Kosciolek, B. 1477 Kowalski, K. 1204 Kreuzaler, F. 1049 Krieger, D. T. 1448 Kuffler, S. W. 1501 Kuhn, D. N. 1194 Kunkel, G. 1 1030 Lai, M. M. C. 1265 Lam, L. 1218 Langlois, R. G. 1382 Latarjet, R. 1524 Laver, W. G. 1425 Legg, A. 1284 Lever, J. E. 1323 Levi-Montalcini, R. 1246 Levine, L. 1519 Lieberman, M. A. 1213 Lingwood, C. A. 1524 Liotta, A. S. 1448 Liu, F.-T. 1430 Livneh, Z. 1089 Lockwood, A. H. 1184 Loh, E. 1395 London, 1. M. 1079 Luscher, E. F. 1069 Lust, W. D. 1482 McCandless, D. W. 1482 MacDermot, J. 1135 Maelicke, A. 1064 Mandel, G. 1199 Marangos, P. J. 1515 Markwell, J. P. 1233 Martin, D. W., Jr. 1074 Martinson, H. G. 1030 Martonosi, A. N. 1241 Masters, P. S. 1213 Matsuzawa, H. 1135 Mattis, J. A. 1131 Mayer, S. E. 1472 Merrill, C. 1274 Miki, T. 1126 Miles, D. L. 1018 Miles, D. W. 1018 Minna, J. 1135 Mirzabekov, A. D.

1118 Model, P. 1251 Moncada, V. 1515 Moran, R. G. 1456 Morimoto, T. 1241 Moriyon, R. 1022 Morrison, S. L. 1420 Morrissey, J. J. 1469 Mozola, M. A. 1122 Muller-Eberhard, H. J.

1410 Nash, H. 1363 Ng, A. 1524 Nirenberg, M. 1135 Nomiyama} V. 1145 Nordstrom, J. L. 1049 Ofengand, J. 1054 Ohlrogge, J. B. 1194

v

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AUTHOR INDEX, MARCH 1979

Ohlsson-Wilhelm, B. 1477

Ohtsuki, M. 1228 Olvera, 0. 1519 O'Malley, B. W. 1049 Palay, S. L. 1485 Pardee, A. B. 1298 Parmiani, G. 1415 Passonneau, J. V. 1482 Paugh, B. A. 1515 Paul, S. M. 1515 Payvar, F. 1348 Pellicer, A. 1373 Peterkofsky, A. 1099 Pettican, P. 1284 Pierotti, M. A. 1415 Pledger, W. J. 1279 Plutner, H. 1400 Podack, E. R. 1410 Potter, H. 1084 Powell, J. R. 1519 Prinz, H. 1064 Puck, T. T. 1358 Putnam, F. W. 1104 Quarles, R. H. 1510 Ranu, R. S. 1079 Ratnoff, 0. D. 1461 Reed, J. 1045 Reed, T. A. 1045 Revoltella, R. 1464 Riblet, R. 1395 Rich, A. 1118 Riddle, V. G. H. 1298 Rinard, G. A. 1472 Roder, J. C. 1405 Rogers, M. J. 1415 Rose, N. R. 1435 Rosen, A. 1405 Rosenberg, M. 1122 Rosenberg, R. D. 1218 Rothgeb, T. M. 1059 Rowley, P. T. 1477 Rozengurt, E. 1284 Rubin, A. H. 1308 Rubinfeld, A. R. 1472 Russell, J. 1204 Sabatini, D. D. 1241 Sabo, S. R. 1338

Safer, B. 1094 Sager, R. 1390 Saito, H. 1461 Salceda, V. M. 1519 Sanui, H. 1308 Scher, C. D. 1279 Scherer, S. 1035 Schimke, R. T. 1348 Schneider, A. B. 1204 Schoen, R. M. 1024 Schramm, M. 1174 Schroder, J. 1453 Senoh, S. 1145 Sharon, J. 1420 Shepherd, H. S. 1353 Sheridan, R. P. 1009 Sherwin, S. A. 1288 Sherwood, L. M. 1204 Shibata, M. 1145 Shimatake, H. 1122 Shooter, E. M. 1269 Silverstein, S. 1373 Skolnick, P. 1515 Skopek, T. R. 1343 Sliski, A. H. 1288 Smardo, F. L., Jr. 1469 Snyder, S. H. 1489 Spears, C. P. 1456 Spector, D. 1348 Sperling, J. 1089 Stalker, D. M. 1150 Stark, A. A. 1343 Stein, E. M. 1026 Stein, L. 1014 Steplewski, Z. 1438 Sternberger, N. H. 1510 Stiles, C. D. 1279 Stinchcomb, D. T. 1035 Struhl, K. 1035 Stubblefield, E. 1348 Stumpf, P. K. 1194 Sugimoto, T. 1145 Sumi, S. M. 1443 Sussman, H. H. 1164 Swaneck, G. E. 1049 Syapin, P. J. 1515 Szabo, A. 1059 Tamura, F. 1126

Thompson, W. C. 1318 Thornber, J. P. 1233 Tillotson, D. 1497 Todaro, G. J. 1288 Tokuyama, T. 1145 Troy, F. A. 1405 True, R. 1030 Tsai, M.-J. 1049 Tsong, T. Y. 1109 Tsuzukida, Y. 1104 Uhl, G. R. 1489 Ullman, B. 1074 Unger, M. 1256 Unkeless, J. C. 1400 Urlaub, G. 1373 Valentine, J. S. 1009 Van Dilla, M. A. 1382 Van Wyk, J. J. 1279 Varmus, H. E. 1348 Vertel, B. M. 1261 Vidair, C. 1308 Vogt, P. K. 1265 von Hippel, P. H. 1040 Wada, H. G. 1164 Waldren, C. 1358 Wang, C.-C. 1104 Weaver, S. 1385 Webster, H. deF. 1510 Webster, R. E. 1169 Webster, R. G. 1425 Weigert, M. 1395 Weisberg, R. A. 1363 Whittaker, R. H. 1338 Wickner, W. 1199 Wigler, M. 1373 Wilson, S. P. 1135 Wittebort, R. J. 1059 Wogan, G. N. 1343 Woodruff, R. I. 1328 Wu, R. 1179 Wulff, D. L. 1122 Yamada, K. M. 1160 Yang, R. C. A. 1179 Yankner, B. A. 1269 Yau, S.-T. 1024 Yura, T. 1126

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Contents (Continued from page ix)

POPULATION BIOLOGY

Evidence for selection by male mating success in natural populations of W. W. Anderson, L. Levine, 0. Olvera, 1519-1523 Drosophila pseudoobscura (components of selection/evolution/population J. R. Powell, M. E. de la Rosa, V. genetics) M. Salceda, M. I. Gaso, and J.

Guzman

Corrections

APPLIED BIOLOGY

Dose-response and competing risks (censored data/dependent risks/linear Peter G. Groer 1524 hypothesis)

B3IOCHEMISTRY

A gene adjacent to satellite DNA in Drosophila melanogaster (molecular Marian Carlson and Douglas Brutlag 1524 cloning/heterochromatin/transcription/repeated gene family)

CELL BIOLOGY

Monovalent antibodies directed to transformation-sensitive membrane C. A. Lingwood, A. Ng, and S. 1524 components inhibit the process of viral transformation (gangliosides! Hakomori galactoprotein a/tumor virus/phenotype)

MICROBIOLOGY

Unusual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt- Clarence J. Gibbs, Jr., D. Carleton 1524 Jakob disease, and scrapie (unconventional viruses) Gajdusek, and R. Latarjet

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Contents (Continued from page x)

MEDICAL SCIENCES

Neurotoxicity of human eosinophils (Gordon phenomenon/leukocytes/white David T. Durack, S. Mark Sumi, and 1443-1447 matter/Purkinje cells) Seymour J. Klebanoff

Biosynthesis in vitro of immunoreactive 31,000-dalton corticotropin/ Anthony S. Liotta, David 1448-1452 3-endorphin-like material by bovine hypothalamus (arcuate nucleus! Gildersleeve, Michael J.

f3-lipotropin/pro-opiocortin) Brownstein, and Dorothy T. Krieger

Fetal cells in the blood of pregnant women: Detection and enrichment by Leonard A. Herzenberg, Diana W. 1453-1455 fluorescence-activated cell sorting (Ychromatin/HLA/prenatal diagnosis! Bianchi, Jim Schr6der, Howard M. chromosome abnormalities) Cann, and G. Michael Iverson

Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive. Richard G. Moran, C. Paul Spears, 1456-1460 methods for the determination of 5-fluoro-2'-deoxyuridylate, and Charles Heidelberger 2'-deoxyuridylate, and thymidylate synthetase (competitive ligand binding assay/cancer chemotherapy/fluorinated pyrimidines/stoichiometric binding)

Amidolytic properties of single-chain activated Hageman factor (Factor XI/ Oscar D. Ratnoff and Hidehiko Saito 1461-1463 Factor XII/Fletcher factor/Fitzgerald factor)

In vitro transformation of mouse bone marrow cells by the polycythemic strain R. Revoltella, L. Bertolini, and C. 1464-1468 of Friend leukemia virus (spleen focus-forming virus) Friend

Evidence for internal homology in bovine preproparathyroid hormone David V. Cohn, Fred L. Smardo, Jr., 1469-1471 (parathyrin/peptide structure/evolution) and Jeremiah J. Morrissey

Depressed cyclic AMP levels in airway smooth muscle from asthmatic dogs Gilbert A. Rinard, Abe R. Rubinfeld, 1472-1476 (tracheal/bronchial/l-adrenergic/isoproterenol/relaxation) Laurence L. Brunton, and Steven

E. Mayer

Hemoglobin synthesis in cultures of hepatic erythroid cells from the human Peter T. Rowley, Betsy 1477-1481 fetus (differentiation/erythropoietin/cell culture/abortus/gene expression) Ohlsson-Wilhelm, Barbara A.

Farley, and Barbara Kosciolek

MICROBIOLOGY

Unusual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt- Clarence J. Gibbs, Jr., D. Carleton 1524 Jakob disease, and scrapie (Correction) (unconventional viruses) Gajdusek, and R. Latarjet

NEUROBIOLOGY

Sparing of metabolic stress in Purkinje cells after maximal electroshock David W. McCandless, Gretchen K. 1482-1484 (pyramidal neurons/energy stores in brain/seizures) Feussner, W. David Lust, and Janet

V. Passonneau

Immunocytochemical localization of cyclic GMP: Light and electron microscope V. Chan-Palay and S. L. Palay 1485-1488 evidence for involvement of neuroglia (cerebellum/cyclic AMP/ ,y-aminobutyric acid/harmaline/diazepam)

Bradykinin-like immunoreactive neuronal systems localized histochemically in Fernando M. A. Correa, Robert B. 1489-1493 rat brain (kinin distribution/indirect immunofluorescence/central nervous Innis, George R. Uhl, and Solomon system) H. Snyder

Retrograde transport of nerve growth factor in chicken embryo (dorsal root Judy K. Brunso-Bechtold and Viktor 1494-1496 ganglia/specificity/polyacrylamide gel pellets) Hamburger

Inactivation of Ca conductance dependent on entry of Ca ions in molluscan Douglas Tillotson 1497-1500 neurons (Ca channel inactivation/nystatin/cesium loading/Aplysia neurons)

A peptide as a possible transmitter in sympathetic ganglia of the frog Yuh Nung Jan, Lily Yeh Jan, and 1501-1505 [luteinizing hormone-releasing hormone (luliberin)/slow potentials] Stephen W. Kuffler

Stereocilia mediate transduction in vertebrate hair cells (auditory system/ A. J. Hudspeth and R. Jacobs 1506-1509 cilium/vestibular system)

Myelin-associated glycoprotein demonstrated immunocytochemically in myelin Nancy H. Sternberger, Richard H. 1510-1514 and myelin-forming cells of developing rat (central nervous system! Quarles, Yasuto Itoyama, and peripheral nervous system/oligodendroglia/Schwann cells/peroxidase- Henry deF. Webster antiperoxidase)

Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes Phil Skolnick, Peter J. Syapin, Beth 1515-1518 pentylenetetrazole-evoked seizures A. Paugh, Victoria Moncada, Paul

J. Marangos, and Steven M. Paul

(Continued on page viii)

ix,

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Contents (Continued from page xi)

Gene localization by chromosome fractionation: Globin genes are on at least two Stephen H. Hughes, Elton 1348-1352 chromosomes and three estrogen-inducible genes are on three chromosomes Stubblefield, Farhang Payvar, (chromosome isolation/gene mapping/flow microfluorimetry/endogenous James D. Engel, Jerry B. Dodgson, viral genes) Deborah Spector, Barbara Cordell,

Robert T. Schimke, and Harold E. Varmus

Mutations in nine chloroplast loci of Chlamydomonas affecting different Hurley S. Sheperd, John E. Boynton, 1353-1357 photosynthetic functions (chloroplast genetics/chloroplast ribosomes) and Nicholas W. Gillham

Measurement of mutagenesis in mammalian cells (environmental screening/ Charles Waldren, Carol Jones, and 1358-1362 carcinogenesis/genetic disease) Theodore T. Puck

Strand exchange in site-specific recombination (phage X/Holliday model) L. W. Enquist, H. Nash, and R. A. 1363-1367 Weisberg

Allelic pairing and gene regulation: A model for the zeste-white interaction in Joseph W. Jack and Burke H. Judd 1368-1372 Drosophila melanogaster (repressor/nuclear architecture/transvection)

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into Michael Wigler, Angel Pellicer, Saul 1373-1376 mammalian cells (biochemical transformation/unique genes/mutant cells) Silverstein, Richard Axel, Gail

Urlaub, and Lawrence Chasin

Genetic control of chromosome breakage and rejoining in Drosophila Maurizio Gatti 1377-1381 melanogaster: Spontaneous chromosome aberrations in X-linked mutants defective in DNA metabolism (recombination-defective meiotic mutants/ mutagen-sensitive mutants/chromosome aberrations in neuroblast cells)

Measurement and purification of human chromosomes by flow cytometry and A. V. Carrano, J. W. Gray, R. G. 1382-1384 sorting (isolated chromosomes/DNA cytophotometry/flow Langlois, K. J. Burkhart-Schultz, microfluorometer) and M. A. Van Dilla

DNA fragments of the Mus musculus ,B globin haplotypes Hbbs and Hbbd Steven Weaver, Nancy L. Haigwood, 1385-1389 (RPC-5 chromatography/restriction enzyme analysis/mouse 3 globin Clyde A. Hutchison III, and genes/embryonic globin genes) Marshall H. Edgell

Role of methylation in the modification and restriction of chloroplast DNA in William G. Burton, Constance T. 1390-1394 Chlamydomonas (genetics/maternal inheritance/5-methylcytosine) Grabowy, and Ruth Sager

IMMUNOLOGY

Myeloma proteins from NZB and BALB/c mice: Structural and functional E. Loh, B. Black, R. Riblet, M. 1395-1399 differences (protein sequence/genealogical analysis/NZB myeloma Weigert, J. M. Hood, and L. Hood immunoglobulins)

Fc-receptor variants of a mouse macrophage cell line (somatic cell genetics/ Jay C. Unkeless, Gilla Kaplan, Helen 1400-1404 complement receptor/antigen-antibody complexes/mouse IgG subclasses) Plutner, and Zanvil A. Cohn

Target-effector interaction in the natural killer cell system: Isolation of target John C. Roder, Anders Rosen, Eva 1405-1409 structures (tumor antigens/cell contact/NaDodSO4 gels/histocompatibility Maria Fenyo, and Frederic A. Troy antigens/oncornavirus antigens)

Molecular reorganization of lipid bilayers by complement: A possible Alfred F. Esser, William P. Kolb, 1410-1414 mechanism for membranolysis (immune cytolysis/membrane structure/spin Eckhard R. Podack, and Hans J. labeling) Muller-Eberhard

Biochemical characterization of alien H-2 antigens expressed on a Michael J. Rogers, Ettore Appella, 1415-1419 methylcholanthrene-induced tumor (histocompatibility antigens/detergent Marco A. Pierotti, Giovanni purification/immunoprecipitation) Invernizzi, and Giorgio Parmiani

Detection of specific hybridoma clones by replica immunoadsorption of their Jacqueline Sharon, Sherie L. 1420-1424 secreted antibodies (cloning in agarose/nitrocellulose filters/monoclonal Morrison, and Elvin A. Kabat antibodies/erythrocyte adherence assay/autoradiography)

Antigenic drift in type A influenza virus: Peptide mapping and antigenic W. G. Laver, W. Gerhard, R. G. 1425-1429 analysis of A/PR/8/34 (HONi) variants selected with monoclonal antibodies Webster, M. E. Frankel, and G. M. (antigenic variants/hemagglutinin/peptide maps/amino acid changes) Air

Immunological tolerance to allergenic protein determinants: A therapeutic Fu-Tong Liu and David H. Katz 1430-1434 approach for selective inhibition of IgE antibody production [ragweed antigen E-poly(D Glu,Lys)/ovalbumin-poly(D Glu,Lys)/IgE antibodies! human allergies/immunotherapyj

Influence of major histocompatibility haplotype on autoimmune disease varies Larry D. Bacon and Noel R. Rose 1435-1437 in different inbred families of chickens (major histocompatibility complex, B haplotype/thyroiditis)

Colorectal carcinoma-specific antigen: Detection by means of monoclonal Meenhard Herlyn, Zenon Steplewski, 1438-1442 antibodies (human cancer/hybridoma/anticolorectal antibodies) Dorothee Herlyn, and Hilary

Koprowski

(Continued on page ix)

x

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Contents (Continued from page xii)

Simultaneous localization of type II collagen and core protein of chondroitin Barbara M. Vertel and Albert 1261-1264 sulfate proteoglycan in individual chondrocytes (differentiation/cartilage Dorfman matrix/immunofluorescence)

Genome of avian myelocytomatosis virus MC29: Analysis by heteroduplex Sylvia S. F. Hu, Michael M. C. Lai, 1265-1268 mapping (genetic substitution/transforming gene/viral defectiveness) and Peter K. Vogt

Nerve growth factor in the nucleus: Interaction with receptors on the nuclear Bruce A. Yankner and Eric M. 1269-1273 membrane (pheochromocytoma/hormone internalization/receptor Shooter regulation)

Production of a tissue-like structure by contraction of collagen lattices by Eugene Bell, Bengt Ivarsson, and 1274-1278 human fibroblasts of different proliferative potential in vitro (tissue Charlotte Merrill structure/hydrated collagen lattice/fibroblast function/cell aging/ contractility)

Dual control of cell growth by somatomedins and platelet-derived growth factor C. D. Stiles, G. T. Capone, C. D. 1279-1283 (competence/progression/BALB/c 3T3/insulinlike activity/simian virus 40) Scher, H. N. Antoniades, J. J. Van

Wyk, and W. J. Pledger

Vasopressin stimulation of mouse 3T3 cell growth (DNA synthesis/growth Enrique Rozengurt, Ann Legg, and 1284-1287 control/epidermal growth factor/insulin/oxytocin) Patricia Pettican

Human melanoma cells have both nerve growth factor and nerve growth factor- Stephen A. Sherwin, Ann H. Sliski, 1288-1292 specific receptors on their cell surfaces (membrane immunofluorescence/ and George J. Todaro neural crest cell property/tumor-associated antigen)

Induction of terminal differentiation in human promyelocytic leukemia cells by Eliezer Huberman and Michael F. 1293-1297 tumor-promoting agents (myeloid differentiation/phagocytosis/phorbol Callaham diesters)

Changes in the synthesis of actin and other cell proteins after stimulation of Veronica G. H. Riddle, Robert 1298-1302 serum-arrested cells (3T3 mouse cells/polyacrylamide gels/marker Dubrow, and Arthur B. Pardee proteins)

Presence of heparan sulfate in the glomerular basement membrane Yashpal S. Kanwar and Marilyn G. 1303-1307 (glycosaminoglycans/anionic sites/glomerular filtration) Farquhar

Separate roles for calcium and magnesium in their synergistic effect on uridine D. F. Bowen-Pope, C. Vidair, H. 1308-1312 uptake by cultured cells: Significance for growth control (membrane Sanui, and A. H. Rubin permeability/transport and phosphorylation/DNA synthesis/intracellular Na+, K+)

Reversion to methionine independence in simian virus 40-transformed human Robert M. Hoffman, Stephen J. 1313-1317 and malignant rat fibroblasts is associated with altered ploidy and altered Jacobsen, and Richard W. Erbe properties of transformation (positive metabolic selection/human transformation revertants)

Intact microtubules are required for rapid turnover of carboxyl-terminal William C. Thompson, Grace G. 1318-1322 tyrosine of a-tubulin in cell cultures (tubulin:tyrosine ligase/post- Deanin, and Malcolm W. Gordon translation/myogenic cells/hypertonic initiation block/colchicine)

Inducers of mammalian cell differentiation stimulate dome formation in a Julia E. Lever 1323-1327 differentiated kidney epithelial cell line (MDCK) (sodium butyrate/cyclic AMP/cryoprotective solvents/purines/renal transepithelial transport)

Monovalent antibodies directed to transformation-sensitive membrane C. A. Lingwood, A. Ng, and S. 1524 components inhibit the process of viral transformation (Correction) Hakomori (gangliosides/galactoprotein a/tumor virus/phenotype)

DEVELOPMENTAL BIOLOGY

Large electrical currents traverse developing Cecropia follicles (pattern Lionel F. Jaffe and Richard I. 1328-1332 formation/oogenesis/Lepidoptera/vibrating probe/germ plasma) Woodruff

Analysis of the constancy of DNA sequences during development and evolution Scott W. Emmons, Michael R. Klass, 1333-1337 of the nematode Caenorhabditis elegans (Southern transfer/DNA-DNA and David I. Hirsh hybridization/DNA rearrangements/speciation/molecular evolution)

ECOLOGY

Bird niches in a subalpine forest: An indirect ordination (community structure/ Stephen R. Sabo and Robert H. 1338-1342 multivari ate technique/niche width and overlap) Whittaker

GENETICS

Aflatoxin B1 mutagenesis, DNA binding, and adduct formation in Salmonella A. A. Stark, J. M. Essigmann, A. L. 1343-1347 typhimurium (chemical carcinogens/mycotoxins) Demain, T. R. Skopek, and G. N.

Wogan

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Contents (Continued from inside back cover)

Bacteriophage fl infection of Escherichia coli: Identification and possible Jay S. Cashman and Robert E. 1169-1173 processing of fl-specific mRNAs in vivo (protein synthesis/gene V and VIII Webster proteins/rifampicin)

Transfer of glucagon receptor from liver membranes to a foreign adenylate Michael Schramm 1174-1178 cyclase by a membrane fusion procedure (hormone receptors/membrane hybridization/cell fusion/l3-adrenergic receptor/phospholipids)

BK virus DNA sequence: Extent of homology with simian virus 40 DNA (tumor Robert C. A. Yang and Ray Wu 1179-1183 virus/DNA sequence analysislviral proteins)

Molecules in mammalian brain that interact with the colchicine site on tubulin Arthur H. Lockwood 1184-1188 (microtubules/endorphins/spindle poisons/chemotherapeutic drugs/Vinca alkaloids)

Models of fibrin (fiber volume/helical protofibrils/space groups) Jan Hermans 1189-1193

Subcellular localization of acyl carrier protein in leaf protoplasts of Spinacia John B. Ohlrogge, David N. Kuhn, 1194-1198 oleracea (acyl carrier protein radioimmunoassay/acyl carrier protein- and P. K. Stumpf dependent fatty acid synthesis/chloroplast function/site of fatty acid synthesis in plants

Soluble precursor of an integral membrane protein: Synthesis of procoat protein Koreaki Ito, Gail Mandel, and 1199-1203 in Escherichia coli infected with bacteriophage M13 (membrane assembly/ William Wickner signal hypothesis/membrane trigger hypothesis)

Preparation of a disulfide-linked dimer of human placental lactogen fragment John Russell, Louis M. Sherwood, 1204-1207 1-134 with immunologic and biologic activity (plasmin/lactogenic activity/ Kazimierz Kowalski, and Arthur receptor assay) B. Schneider

Glycosylation of human chorionic gonadotropin in mRNA-dependent cell-free Malgorzata Bielinska and Irving 1208-1212 extracts: Post-translational processing of an asparagine-linked mannose-rich Boime oligosaccharide (carbohydrate processing in vitro/glycoprotein hormone/ cell-free protein synthesis)

Requirement of acetyl phosphate for the binding protein-dependent transport Jen-shiang Hong, Arthur G. Hunt, 1213-1217 systems in Escherichia coli [shock-sensitive transport system/phosphate Paul S. Masters, and Michael A. acetyltransferase (phosphotransacetylase)/acetate kinase/ecf mutant/ Lieberman acetyl coenzyme A]

Correlation between structure and function of heparin (mucopolysaccharide/ Robert D. Rosenberg and Lun Lam 1218-1222 anticoagulant function)

Replication in vitro of the 2-,um DNA plasmid of yeast (cell-free extracts/cell S. Michal Jazwinski and Gerald M. 1223-1227 cycle/growth control/cdc mutants/Saccharomyces) Edelman

A gene adjacent to satellite DNA in Drosophila melanogaster (Correction) Marian Carlson and Douglas Brutlag 1524 (molecular cloning/heterochromatin/transcription/repeated gene family)

BIOPHYSICS

Dark field imaging of biological macromolecules with the scanning transmission Mitsuo Ohtsuki, Michael S. Isaacson, 1228-1232 electron microscope (phase contrast/low-dose electron microscopy/ and A. V. Crewe unstained biological macromolecules/dark field contrast/thin carbon films)

BOTANY

Higher plant chloroplasts: Evidence that all the chlorophyll exists as John P. Markwell, J. Philip Thornber, 1233-1235 chlorophyll-protein complexes (Zea mays L./zwitterionic detergent/ and Russell T. Boggs electrophoretic fractionation)

CELL BIOLOGY

Lateral translational diffusion of cytochrome c oxidase in the mitochondrial Matthias Hochli and Charles R. 1236-1240 energy-transducing membrane (membrane structure/protein diffusion/ Hackenbrock electron transfer/immunoglobulin probes/freeze-fracture)

In vitro synthesis of the Ca2+ transport ATPase by ribosomes bound to Ted L. Chyn, Anthony N. Martonosi, 1241-1245 sarcoplasmic reticulum membranes (chicken embryonic muscle cells/ Takashi Morimoto, and David D. integral membrane proteins/tryptic peptide map/membrane biogenesis) Sabatini

Nerve growth factor-induced transformation of immature chromaffin cells in Luigi Aloe and Rita Levi-Montalcini 1246-1250 vivo into sympathetic neurons: Effect of antiserum to nerve growth factor (primitive sympathetic celts/pheochromoblasts/adrenal medulla)

Membrane biogenesis: Cotranslational integration of the bacteriophage fi coat Chung Nan Chang, Peter Model, and 1251-1255 protein into an Escherichia coli membrane fraction (bacteriophage fi DNA/ Gunter Blobel coupled transcription-translation system/post- translational proteolysisi sequence determination/topology of coat protein

Differentiation of a rat mammary cell line in vitro (stem celts/myoepithelial Renato D)ulbecco, Mauro Bologna, 1256-1260 cells/domes/immunofluorescence ) and Michael Unger

((Contirwzed onl pagfe Xi)

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