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Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes...

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Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C. AdamsLauren Baker, Caroline Barnes, Ryan Beveridge, Emma Cambridge, Damian Carragher, Prabhjoat Chana, Kay Clarke, Yvette Hooks, Natalia Igosheva, Ozama Ismail, Hannah Jackson, Leanne Kane, Rosalind Lacey, David Tino Lafont, Mark Lucas, Simon Maguire, Katherine McGill, Rebecca E. McIntyre, Sophie Messager, Lynda Mottram, Lee Mulderrig, Selina Pearson, Hayley J. Protheroe, Laura-Anne Roberson, Grace Salsbury, Mark Sanderson, Daniel Sanger, Carl Shannon, Paul C. Thompson, Elizabeth Tuck, Valerie E. Vancollie, Lisa Brackenbury, Wendy Bushell, Ross Cook, Priya Dalvi, Diane Gleeson, Bishoy Habib, Matt Hardy, Kifayathullah Liakath-Ali, Evelina Miklejewska, Stacey Price, Debarati Sethi, Elizabeth Trenchard, Dominique von Schiller, Sapna Vyas, Anthony P. West, John Woodward, Elizabeth Wynn, Arthur Evans, David Gannon, Mark Griffiths, Simon Holroyd, Vivek Iyer, Christian Kipp, Morag Lewis, Wei Li, Darren Oakley, David Richardson, Damian Smedley, Chukwuma Agu, Jackie Bryant, Liz Delaney, Nadia I. Gueorguieva, Helen Tharagonnet, Anne J. Townsend, Daniel Biggs, Ellen Brown, Adam Collinson, Charles-Etienne Dumeau, Evelyn Grau, Sarah Harrison, James Harrison, Catherine E. Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, Tom Metcalf, Stuart Newman, Johanna Pass, Laila Pearson, Helen Reynolds, Caroline Sinclair, Hannah Wardle-Jones, Michael Woods, Liam Alexander, Terry Brown, Francesca Flack, Carole Frost, Nicola Griggs, Silvia Hrnciarova, Andrea Kirton, Jordan McDermott, Claire Rogerson, Gemma White, Pawel Zielezinski, Tia DiTommaso, Andrew Edwards, Emma Heath, Mary Ann Mahajan, Binnaz Yalcin, David Tannahill, Darren W. Logan, Daniel G. MacArthur, Jonathan Flint, Vinit B. Mahajan, Stephen H. Tsang, Ian Smyth, Fiona M. Watt, William C. Skarnes, Gordon Dougan, David J. Adams, Ramiro Ramirez-Solis, Allan Bradley, Karen P. SteelJacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C. AdamsLauren Baker, Caroline Barnes, Ryan Beveridge, Emma Cambridge, Damian Carragher, Prabhjoat Chana, Kay Clarke, Yvette Hooks, Natalia Igosheva, Ozama Ismail, Hannah Jackson, Leanne Kane, Rosalind Lacey, David Tino Lafont, Mark Lucas, Simon Maguire, Katherine McGill, Rebecca E. McIntyre, Sophie Messager, Lynda Mottram, Lee Mulderrig, Selina Pearson, Hayley J. Protheroe, Laura-Anne Roberson, Grace Salsbury, Mark Sanderson, Daniel Sanger, Carl Shannon, Paul C. Thompson, Elizabeth Tuck, Valerie E. Vancollie, Lisa Brackenbury, Wendy Bushell, Ross Cook, Priya Dalvi, Diane Gleeson, Bishoy Habib, Matt Hardy, Kifayathullah Liakath-Ali, Evelina Miklejewska, Stacey Price, Debarati Sethi, Elizabeth Trenchard, Dominique von Schiller, Sapna Vyas, Anthony P. West, John Woodward, Elizabeth Wynn, Arthur Evans, David Gannon, Mark Griffiths, Simon Holroyd, Vivek Iyer, Christian Kipp, Morag Lewis, Wei Li, Darren Oakley, David Richardson, Damian Smedley, Chukwuma Agu, Jackie Bryant, Liz Delaney, Nadia I. Gueorguieva, Helen Tharagonnet, Anne J. Townsend, Daniel Biggs, Ellen Brown, Adam Collinson, Charles-Etienne Dumeau, Evelyn Grau, Sarah Harrison, James Harrison, Catherine E. Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, Tom Metcalf, Stuart Newman, Johanna Pass, Laila Copyright © 2013 The Authors Terms and Conditions
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Page 1: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes 

Jacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C.

AdamsLauren Baker, Caroline Barnes, Ryan Beveridge, Emma Cambridge, Damian Carragher, Prabhjoat Chana, Kay Clarke, Yvette Hooks, Natalia Igosheva, Ozama Ismail, Hannah Jackson, Leanne Kane, Rosalind Lacey, David Tino Lafont, Mark Lucas, Simon

Maguire, Katherine McGill, Rebecca E. McIntyre, Sophie Messager, Lynda Mottram, Lee Mulderrig, Selina Pearson, Hayley J. Protheroe, Laura-Anne Roberson, Grace Salsbury, Mark Sanderson, Daniel Sanger, Carl Shannon, Paul C. Thompson, Elizabeth Tuck, Valerie E. Vancollie, Lisa Brackenbury, Wendy Bushell, Ross Cook, Priya Dalvi, Diane Gleeson, Bishoy Habib, Matt Hardy, Kifayathullah

Liakath-Ali, Evelina Miklejewska, Stacey Price, Debarati Sethi, Elizabeth Trenchard, Dominique von Schiller, Sapna Vyas, Anthony P. West, John Woodward, Elizabeth Wynn, Arthur Evans, David Gannon, Mark Griffiths, Simon Holroyd, Vivek Iyer, Christian Kipp, Morag Lewis, Wei Li, Darren Oakley, David Richardson, Damian Smedley, Chukwuma Agu, Jackie Bryant, Liz Delaney, Nadia I. Gueorguieva,

Helen Tharagonnet, Anne J. Townsend, Daniel Biggs, Ellen Brown, Adam Collinson, Charles-Etienne Dumeau, Evelyn Grau, Sarah Harrison, James Harrison, Catherine E. Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, Tom Metcalf, Stuart Newman, Johanna

Pass, Laila Pearson, Helen Reynolds, Caroline Sinclair, Hannah Wardle-Jones, Michael Woods, Liam Alexander, Terry Brown, Francesca Flack, Carole Frost, Nicola Griggs, Silvia Hrnciarova, Andrea Kirton, Jordan McDermott, Claire Rogerson, Gemma White, Pawel Zielezinski, Tia DiTommaso, Andrew Edwards, Emma Heath, Mary Ann Mahajan, Binnaz Yalcin, David Tannahill, Darren W. Logan, Daniel G. MacArthur, Jonathan Flint, Vinit B. Mahajan, Stephen H. Tsang, Ian Smyth, Fiona M. Watt, William C. Skarnes, Gordon Dougan, David J. Adams, Ramiro Ramirez-Solis, Allan Bradley, Karen P. SteelJacqueline K. White, Anna-Karin Gerdin,

Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C. AdamsLauren Baker, Caroline Barnes, Ryan

Beveridge, Emma Cambridge, Damian Carragher, Prabhjoat Chana, Kay Clarke, Yvette Hooks, Natalia Igosheva, Ozama Ismail, Hannah Jackson, Leanne Kane, Rosalind Lacey, David Tino Lafont, Mark Lucas, Simon Maguire, Katherine McGill, Rebecca E. McIntyre, Sophie Messager, Lynda Mottram, Lee Mulderrig, Selina Pearson, Hayley J. Protheroe, Laura-Anne Roberson, Grace

Salsbury, Mark Sanderson, Daniel Sanger, Carl Shannon, Paul C. Thompson, Elizabeth Tuck, Valerie E. Vancollie, Lisa Brackenbury, Wendy Bushell, Ross Cook, Priya Dalvi, Diane Gleeson, Bishoy Habib, Matt Hardy, Kifayathullah Liakath-Ali, Evelina Miklejewska,

Stacey Price, Debarati Sethi, Elizabeth Trenchard, Dominique von Schiller, Sapna Vyas, Anthony P. West, John Woodward, Elizabeth Wynn, Arthur Evans, David Gannon, Mark Griffiths, Simon Holroyd, Vivek Iyer, Christian Kipp, Morag Lewis, Wei Li, Darren Oakley,

David Richardson, Damian Smedley, Chukwuma Agu, Jackie Bryant, Liz Delaney, Nadia I. Gueorguieva, Helen Tharagonnet, Anne J. Townsend, Daniel Biggs, Ellen Brown, Adam Collinson, Charles-Etienne Dumeau, Evelyn Grau, Sarah Harrison, James Harrison,

Catherine E. Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, Tom Metcalf, Stuart Newman, Johanna Pass, Laila Pearson, Helen Reynolds, Caroline Sinclair, Hannah Wardle-Jones, Michael Woods, Liam Alexander, Terry Brown, Francesca Flack, Carole Frost,

Nicola Griggs, Silvia Hrnciarova, Andrea Kirton, Jordan McDermott, Claire Rogerson, Gemma White, Pawel Zielezinski, Tia DiTommaso, Andrew Edwards, Emma Heath, Mary Ann Mahajan, Binnaz Yalcin, David Tannahill, Darren W. Logan, Daniel G. MacArthur, Jonathan

Flint, Vinit B. Mahajan, Stephen H. Tsang, Ian Smyth, Fiona M. Watt, William C. Skarnes, Gordon Dougan, David J. Adams, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel 

Cell Volume 154, Issue 2, Pages 452-464 (July 2013)

DOI: 10.1016/j.cell.2013.06.022

Copyright © 2013 The Authors Terms and Conditions

Page 2: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure 1

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 3: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure 2

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 4: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure 3

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 5: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure 4

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 6: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure 5

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 7: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure 6

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 8: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure 7

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 9: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure S1

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 10: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure S2

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 11: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Figure S3

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions

Page 12: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes Jacqueline K. White, Anna-Karin Gerdin, Natasha A.

Cell 2013 154, 452-464DOI: (10.1016/j.cell.2013.06.022) Copyright © 2013 The Authors Terms and Conditions


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