811

INDEX

Volume 228, January-March, 1984

Acara, M., see Rennick, B., 387Acetaminophen, glucuronidation

and biliary excretion (rats),407

N.Acetylation, isoniazid toxicityand (rabbits), 588

Acetylcholineintrapulmonary artery relaxa-

tion and, cyclic GMP accu-mulation (cows), 682

nictotinic, receptor, bicyclo-oc-

tane analogs on ionic chan.nels (frogs), 73

release, neurotransmitter regu-

lation (rats), 209sensitization to, electroconvul-

sive shock, hippocampus(rat), 230

N-Acetyltransferase, benzodiaxe-

pine effects on, pinealocytes(rats), 434

Adenosineanalogs, sleep and (rats), 268isoproterenol-induced electro-

physiological changes and(dogs), 792

relaxation, cyclic AMP proteinkinase, coronary arterial

smooth muscle (cows), 342Adenosine-5’-N-ethylcarboxam-

ide, sleep and (rats), 268Na�,K�-adenosine triphospha-

tase, methanethiol effects(rats), 103

regulation, sympathetic ner-

vous system (rats), 304Adenylate cylase

interaction with G-protein, al-cohol effects on (mice), 579

isoproterenol, beta blockade

(humans), 461receptor-mediated inhibition,

N-ethylmaleimide and, 425

Adipose tissue, brown, adenosinetriphosphatase regulation

and (rats), 304Adrenalectomy, norepinephrine

release, negative feedback

control (rats), 287Adrenal medulla, dopamine ana-

log-induced hyperglycemia(rate), 551

Adrenoceptor

a4.tha and beta, spontaneous hy-pertension and (rats), 454

alpha-i and a�pha-2, rauwol-seine, RX 781094 and RS21361 as antagonists (rats),739

alpha-2, activation with norepi-nephrine (rats), 725

a�pha-2 agonists, hypergly-cemia (rats), 168

beta, blockade by propafenone

(humans), 461

beta-i and beta-2, vascular(rats), 733

Agonista�pha-2 adrenoceptor, 5-hy-

droxytryptamine release and(rats), 725

a�pha-2 adrenoceptor, hyper-glycemia and (rats), 168

beta adrenergic receptors and(rats), 640

dopamine, hyperglycemia in-duced by (rats), 551

opiate, behavior and (monkey),669

opiate, kindled amygdaloid sei-zures and (rats), 620

Aguayo, L. G., Weinstein, H.,Maayani, S., Glick, S. D.,Warnick, J. E. and Albuquer-que, E. X.: Discriminant ef-fects of behaviorally activeand inactive analogs of phen-

cyclidine on membrane excit-

ability, 80Ahmed, K., Zieve, L. and Quar-

forth, G.: Effects of metha-nethiol on erythrocyte mem-brane stabilization and onNa�,K�-adenosine triphos-phatase: Relevance to he-patic coma, 103

Airway

calcium antagonists and(guinea pigs), 612

nasal, resistance, prostaglandin

E1 and (dogs), 215smooth muscle contraction, im-

munoglobulin G- and E-me-diated (guinea pig), 116

Alkylating agent, renal functionand ultrastructure, acute ef-fects (dogs), 799

Akaike, N., Yatani, A., Nishi, K.,

Oyama, Y. and Kuraoka, S.:Permeability to various cat-

ions ofthe voltage-dependentsodium channel of rat singleheart cells, 225

Akera T., see Kim, D., 537Albertson, T. E., Joy, R. M. and

Stark, L. G.: Modification ofkindled amygdaloid seizures

by opiate agonists and antag-onists, 620

Albuquerque, E. X., see Aguayo,

L. G., 80Albuquerque, E. X., see Warnick,

J. E., 73Alderdice, M. T., see Talbot, P.

A., 121

Amantadine, bicyclo-octane ana-logs, ionic channels (frogs),73

‘y-Aminobutyric acid

response augmentation, norepi-

nephrine and benzodiazepineeffects (rats), 257

sensitization to, electroconvul-sive shock, hippocampus(rats), 230

uptake, inhibitors (rats, mice),109

p-Aminohippurate, urate excre-tion (monkeys), 252

Aminopyridine, synaptic Ca�� de-pendence (frogs), 573

AMP, cyclic, see Cyclic AMPAmphetamine, halogenated deny-

atives, pituitary-adrenocorti-cal activity (rats), 593

Amrinone, congestive heart fail-ure and (humans), 319

Analgesia, opioid, meptazinol

(rats, mice), 414Anderson, G. F. and Marks, B.

H.: Beta adrenoreceptors inthe rabbit bladder detrusormuscle, 283

Anderson, K. E., Simionatto, C.S., Drummond, G. S. andKappas, A.: Tissue distnibu-

tion of tin-protoporphyrin, apotent competitive inhibitorof heme oxygenase, 327

Andersson, K.-E., see Hogest#{228}tt,

E.D., 187Angiotensin, enzyme converting,

inhibitor, CI-907 (guinea

pigs), 312

Antagonista�pha-1/aZpha-2 adrenoceptor,

rauwolscine, RX 781094 andRS 21361 (rats), 739

bronchoconstriction, SK&F88046 (guinea pigs), 128

calcium, airway responses and(guinea pigs), 612

calcium, cardiac injury and(rats), 761

calcium renal tubular site of ac-

tion of felodipine (rats), 420narcotic, opiate withdrawal and

intestinal fluid exchange

(rats), 364opiate, behavior and (monkey),

669opiate, kindled amygdaloid sei-

nines and (rats), 620serotonin, quipazine cue and

(rats), 628serotonin, receptors and (rats),

133

thromboxane A2/prostaglandin

H2 receptor, platelet aggre-gation (humans), 240

Antiallergic agent, Ro 22-3747,immediate hypersensitivity

diseases (rats), 57Antiasthmatic agent, Ro 22-3747,

immediate hypersensitivity

diseases (rats), 57Anticonvulsants

‘y-aminobutynic acid inhibition

(rats, mice), 109phenytoin, sodium channel

blocking (mice), 523quantal release (frogs), 121

Antidepressants, chronic, pinealgland and (rats), 545

Antidepressive treatment, sero-tonin, electroconvulsiveshock and (rats), 230

Antihemolysis, methanethiol, he-patic coma and (rats), 103

Antihypertensive drugsCI-907, angiotensin converting

enzyme inhibitor (guineapigs), 312

negative feedback control,(rats), 287

Aorta, beta receptor mechanisms(rats), 733

Apomorphine, dopamine receptoractivation, kidney (rat), 161

AQ-A 39, cardiac action (dogs),484

Arachidonic acid

metabolism and myocardial sal-vage (dogs), 510

metabolism and renal blood

flow (dogs), 140platelet aggregation and (hu-

mans), 240Arneric, S. P., Chow, S. A., Long,

J. P. and Fischer, L. J.: Do-pamine analog-induced hy-perglycemia in rats: Involve-

ment of the adrenal medullaand the endocrine pancreas,551

Aromatic L-amino acid decarbox-ylase, intrarenal serotonin

formation (rats), 53Atria, isolated, papaverine effects

(rabbits, guinea pigs, rats),500

Automaticity

diltiazem effects, myocardialmembrane (ferrets), 245

ventricular, AQ-A 39 effects(dogs), 484

Aut.onomic nervous system, see

Nervous system

Autoreceptors, dopamine, thiori-dazine and (rabbits), 636

13-Azaprostnoic acid, thrombox-

ane A2-induced platelet ag-gregation and (humans), 240

Bailey, J. C., see Rardon, D. P.,792

Barorfiex, arterial, calcium chan-nel inhibition (dogs), 491

Barrett, R. J., see Friedman, R.

L., 628

812 Index Vol. 228

Bartsch, W., see Sponer, G., 235Baruth, see Welton, A. F., 57

Basophil, histamine release, pros-

taglandin D2 and (human),400

Behaviornoncatecholic phenylethyla-

mine administration and(dogs), 691

opiate agonist/antagonist ef-fects on (monkey), 669

Benzodiazepine

-y-aminobutyric acid augmen-tation (rats), 257

N-acetyltransferaae and, pinealgland (rats), 434

Benzoyl-phenylalanyl-alanyl-

proline, pulmonary angioten-sin-converting enzyme (rab-

bit), 154

Bepridil, membrane electrical ex-citability, phencyclidine an-alogs and (frogs, crayfish), 80

Berry, P. N., see Wolf, C. R, 202Bile, blood, liver cell sidedness

(rats), 19Bile duct, ligation, sulindac and

renal prostaglandin excretion(dogs, swine), 560

Biliary excretion, glucuronidation

and, acetaminophen (rats),

407

Biliary transport, morphine glu-

curonide excretion (rats), 19

Binding assay, radioreceptor,spontaneous hypertensionand (rats), 454

Bladder, detrusor, beta adrenore-ceptors in (rabbit), 283

Bleomycin, pulmonary disposi-tion (mice), 13

Blockadealpha adrenergic, norepineph-

nine release (rats), 287beta adrenoceptor, propafenone

(humans), 461calcium channel, cardiac injury

and (rats), 761calcium channel, diltiazem,

myocardium (ferrets), 245calcium channel, FR 34235, is-

chemia and (dogs), 531calcium channel, phencyclidine

analogs and (frogs, crayfish),80

dynorphin neurotensin excita-bility, myentenic plexus

(guinea pigs), 293ganglionic afterdischarges by

tyramine (hamsters), 376neuromuscular, fragment C of

tetanus toxin and (mice), 600neuromuscular, ORG. 6368,

end plate conductance and(frogs), 567

potency and selectivity, a�pha-

1/a�pha-2 adrenoceptor

(rats), 739sodium channel, phenytoin,

neuroblastoma (mice), 523Blood flow

regional, microspheres (dogs),

28

renal, arachidonic acid metab-olism and (dogs), 140

transmural, calcium blockersand (dogs), 531

Blood pressure

capsaicin-induced changes,

central nervous system site of

action (cats), 719carbachol effects (rats), 354

hormone effects (rats), 348pergolide effects (rats), 779

Blood vesselnitroglycerin uptake and me-

tabolism (rats), 334relaxation, cyclic AMP-de-

pendent protein kinase

(cows), 342resistance, prostaglandin E1 ef-

fecta, nasal (dogs), 215Boucher, D. M., see Ryan, M. J.,

312

Brainbeta adrenergic receptors in

(rats), 640carbachol effects (rats), 354muscaninic cholinergic recep-

tom, I3Hjpirenzephine and[3Hjquinuclidinylbenzilate

binding to (rats), 648neurotransmitter regulation,

presynaptic muscarinic re-

ceptor (rats), 209Breath analysis, scoparone radio-

isomers in (mice), 769Bretz, N. S., see Koechel, D. A.,

799

Brocco, M. J., see Slikker, W., Jr.,43

Bromobenzene, metabolism, hep-

atocytes (rats), 393Bromobenzene-3,4-oxide, stabil-

ity (rats), 393Bromocriptine, depressor mecha-

nism, hypertension and(rats), 370

Bronchoconstniction, leukotniene,

thromboxane and prosta-glandin effects (guinea pigs),128

Bronchus, sensitivity and respon-siveness, calcium antagonists

and (guinea pigs), 612

Brown, D. R., see Chang, E. B.,364

Budd, G. C., see Koechel, D. A.,799

Buprenorphine, behavior and(monkey), 669

Burke, T. M., see Ignarro, L. J.,

682Bylund, D. B., see Feller, D. J.,

275

Calcium

current, diltiazem, myocardium(ferrets), 245

dependence of synaptic trans-mission, aminopyridine ef-

fects (frogs), 573Calcium antagonist

airway responses and (guinea

pigs), 612renal tubular site of action of

felodipine (rats), 420Calcium channel

blocking, cardiac injury and(rats), 761

blocking, diltiazem, myocar-dium (ferrets), 245

blocking, FR 34235, ischemiaand (dogs), 531

blocking, phencylidine analogsand (frogs, crayfish), 80

inhibitors, baroreflex effects(dogs), 491

potassium depolarization, cere-bral artery (rats), 187

voltage- and receptor-operateduterine smooth muscle (rats),

439Calcium paradox, diltiazem and,

heart (rats), 220cAMP, see cyclic AMPCapasaicin, central nervous sys-

tem site of action (cats), 719Carbachol, presser responses

(rats), 354

Carbidopa, aromatic L-amino aciddecarboxylase inhibition, in-trarenal serotonin formation

(rats), 53

Carcinogen, kidney, glutathioneconjugation of hexachloro-butadiene (rats), 202

Cardiac conduction, encainide ef-fects (rabbits, dogs), 180

Cardioprotection, calcium and(rats), 761

Catecholamine

bromocriptine depressor mech-

anism, hypertension and(rats), 370

cardiovascular control (rats),348

endogenous, ganglionic block-ade by tyramine (hamsters),376

Catella, F., see Patrignani, P., 472Cation, monovalent, permeability

to, single heart cells (rats),225

Catto, B. A., Valencia, C. I.,Hafez, K., Fairchild, E. H.and Webster, L. T., Jr.: 4-Keto niridazole: A major nir-idazole metabolite with cen-tral nervous system toxicitydifferent than niridazole, 662

Cavero, I., Lefevre-Borg, F.,Lhoste, F., Sabatier, C.,Richer, C. and Giudicelli, J.-F.: Pharmacological, hemo-dynamic and autonomic ner-

vous system mechanisms re-sponsible for the blood pros-sure and heart rate loweringeffects of pergolide in rats,779

Central nervous system, see Ner-vous system

Cerebral arterypotassium depolarization (rat),

187vasopressin on (humans,

goats), 749Chan, R., see Tyson, C. A., 676Chang, E. B., Brown, D. R., Field,

M. and Miller, R. J.: An an-tiabsorptive basis for precip-

itated withdrawal diarrhea inmorphine-dependent rats,364

Chelator, ionophore-polymenic,iron overload and (rats), 676

Chen, Y.-F., see Nagahama, S.,370

fl-Chlornaltrexamine, selective

protection, dynorphin genepeptides (guinea pigs), 88

p-Chloroamphetamine, corticos-

terones and (rats), 5931-(3-Chloroanilino).4-phenyl-

phthalazine, platelet aggre-gation and (humans), 467

Chow, S. A., see Arneric, S. P.,551

Chremos, A. N., see Zambraski,

E. J., 560Christ, D. and Zitaglio, T.: Block-

ade of ganglionic afterdis-charges by tyramine may bemediated by endogenouscatecholamines, 376

Chromatography

high-performance liquid, sco-

parone radioisomers inbreath analysis (mice), 769

reverse-phase high-perform-

ance, bleomycin pulmonarydisposition (mice), 13

Chronotrophy, papaverine, (rab-bits, guinea pigs, rats), 500

CI-907, nonsulfhydryl angioten-sin converting enzyme inhib-

itor, antihypertensive effects(guinea pigs), 312

Cieslinski, L., see DiTullio, N. W.,169

Ciguatoxin, Spanish mackerel,ileum and vas deferens(guinea pigs), 756

Cimetidine, transport, kidney tu-bules (chickens), 387

Cirrhosis, sulindac and renalprostaglandin excretion(dogs, swine), 560

Clarkson, T. W., see Magos, L.,478

Clearance, metoprolol, estimates(monkey), 774

Clonidine, hyperglycemia and(rats), 168

Cobaltous chloride, scoparone ra-

dioisomers in breath analysis(mice), 769

Cocaine, responding maintained

by, reinstatement (monkeys),43

Cohen, D. M., see Ryan, M. J.,312

Coma, hepatic, methanethiol ef-fects (rats), 103

Conde, M. V., see Lluch, S., 749Conductance, end-plate, ORG.

6368 and (frogs), 567Cone, E. J., McQuinn, R. L. and

Shannon, H. E.: Structure-activity relationship studiesof phencyclidine derivativesin rats, 147

Cooper, T. B., see Friedman, E.,545

Coronary artery

ligation, digoxin toxicity (cats),537

smooth muscle, adenosine re-

la.xation (cows), 342

1984 Index 813

stenosis, calcium blockers and(dogs), 531

stenosis, ischemia (dogs), 28

Corticosterone, 5-hydroxytrypta-mine releasers and (rats), 593

Corynanthine, hyperglycemia and

(rats), 168Crowley, H. J., see Welton, A. F.,

57Cubeddu, L. X., see Niedzwiecki,

D. M., 636Curley, W. H., Standaert, F. G.

and Dretchen, K. L.: Physo.stigmine inhibition of 3’,5’-

cyclic AMP phosphodiester-ase from cat sciatic nerve,656

Cyclic AMPinteraction with G-protein, al-

cohol effects on (mice), 579protein kinase dependent on,

adenosine relaxation (cows),342

3’,5’-Cycic AMP phosphodies-terase, inhibition by physo-stigmine (cats), 656

Cyclic GMPacetylcholine and arterial re-

laxation (cows), 682vasodilators and, intrapulmo-

nary artery relaxation(cows), 33

Cyclic GMP phosphodiesterase,inhibition and purification(humans), 467

Cyclohexyladenosine, sleep and(rats), 268

Cyclooxygenase, renal activity,

arachidonic acid and (dogs),140

Cytochrome P.450, induction bywarfanin (mice), 769

Dawson, M. I., see Tyson, C. A.,676

Dazoxiben, platelet and renalthromboxane (humans), 472

Dellavedova, L., see Groppetti, A.,

446de Montigny, C.: Electroconvul-

sive shock treatments en-hance responsiveness of fore-brain neurons to serotonin,230

Depression, major, sensitizationto drugs by electroconvulsive

shock, hippocampus (rat),230

Depressor mechanism, bromo-

cniptine, hypertension and(rats), 370

DeRossett, S. E. and Holtzman,

S. G.: Effects of naloxone, di-prenorphine, buprenorphineand etorphine on unpunished

and punished fty,yi.reinforcedresponding in the squirrel

monkey, 669

Diarrhea, precipitated with-drawal, opiates and (rats),364

Dias-Souza, J., see Quest, J. A.,719

Dibona, G. F. and Sawin, L. L.:Renal tubular site of action

of felodipine, 420Di#{233}guez,G., see Lluch, S., 749Dietmann, K., see Sponer, G., 235Digitalis, toxicity, ischemia and

(cats), 537Digitoxin, renal clearance (rats),

174Digoxin, toxicity, ischemia and

(cats), 537

Dihydroethacrynic acid, renalfunction and ultrastructure(dogs), 799

2 - (3 - 4 - Dihydroxyphenylimino)

imidazoline, hyperglycemiaand (rats), 168

Diltiazemarterial baroreflexes, calcium

channel inhibition (dogs),491

calcium paradox and, heart(rats), 220

isehemia and (dogs), 531

myocardial membrane (ferrets),

2456,7-Dimethoxycoumarin, radioi-

somers, breath analysis(mice), 769

Diprenorphine, behavior and

(monkey), 669

DiSalvo, J., see Silver, P. J., 342DiTullio, N. W., Cieslinski, L.,

Matthews, W. D. and Storer,B.: Mechanisms involved inthe hyperglycemic responseinduced by clonidine andother a�pha-2 adrenoceptor

agonists, 168Djuricic-Nedelson, M., see Radu-

lovacki, M., 268Dobutamine, amninone or, con-

gestive heart failure (hu-mans), 319

Dopamine

alcoholeffects on G-protein-ad-

enylate cyclase interaction(mice), 579

analog, hyperglycemia inducedby (rats), 551

receptor activation, LY-141865,kidney (rat), 161

receptor stimulation, pergolide

and (dogs), 696

release, neurotransmitter regu-lation (rats), 209

Douglas, J. S., see Duncan, P. G.,612

Dresel, P. E.: Effect of encainideand its two major metaboliteson cardiac conduction, 180

Dretchen, K. L., see Curley, W.H., 656

Drugabuse, cocaine and thiamylal

reinstatement of drug-in-duced responding (monkeys),43

antihypertensive, negativefeedback control (rats), 287

anti-inflammatory, myocardialsalvage (dogs), 510

discrimination, phencyclidine(rats), 147

excretion, cimetidine transport,kidney tubules (chickens),387

hallucinogenic, raphe unit ac-tivity and (cats), 94

Drummond, G. S., see Anderson,

K. E., 327Duncan, P. C. and Douglas, J. S.:

Sensitivity and responsive-

ness of tracheal and bron-chial tissues from young andold guinea pigs: Effect of cal-cium antagonists, 612

Dunn, M. J., see Zambraski, E. J.,560

Durant, N. N. and Horn, R:ORG. 6368: A nondepolaniz-

ing neuromuscular blockingagent with a novel effect onend-plate conductance, 567

Dynorphin

neurotensin contractile activity

inhibition, myentenic plexus(guinea pigs), 293

peptides, opioid receptor selec-tivity (guinea pigs), 88

Edwards, J. C., Ignarro, L. J., Hy-man, A. L. and Kadowitz, P.J.: Relaxation of intrapul-monary artery and vein bynitrogen oxide-containingvasodilators and cyclic GMP,33

Eicosanoid, arachidonic acid and

renal blood flow (dogs), 140Encainide

metabolites, cardiac conduction

(rabbits, dogs), 180polymorphic metabolism (hu-

mans), 605Endean, R., see Lewis, R. J., 756Endele, R., see Sponer, G., 235Endo, T., see Hagiwara, M., 467Endothelium, relaxation, acetyl-

choline and cyclic GMP ef-fects (cows), 682

Engelhardt, D. L., see Matthew,E., 434

Enzymeangiotensin-converting, inhibi-

ton, CI-907 (guinea pigs), 312angiotensin-converting, pul-

monary kinetics (rabbit), 154Erythrocyte, membrane stabili-

zation, methanethiol effects

(rats), 103Essenburg, A. D., see Ryan, M. J.,

312

Estrada, C., see Lluch, S., 749Ethacrynic acid, renal function

and ultrastructure (dogs),799

Ethanol, G-protein-adenylate cy-class interaction and (mice),

579

N-Ethylmaleimide, adenylate cy-clase inhibition and, 425

Etorphine, behavior and (mon-

key), 669

Faden, A. I., see Feuerstein, G.,348

Fairchild, E. H., see Catto, B. A.,662

Feigen, L. 0.: Influence of renallipoxygenase activity on the

renal vascular response to an-

achidonic acid, 140Feller, D. J. and Bylund, D. B.:

Comparison of a�pha-2 adre-nergic receptors and theirregulation in rodent and por-

cine species, 275Felodipine, site of action, renal

tubules (rats), 420Fenfluramine

corticosterones and (rate), 593tolerance, food intake and

(rats), 446

Feuerstein, G., Zerbe, R. L. andFaden, A. I.: Central cardio-vascular effects of vasotocin,oxytocin and vasopressin inconscious rats, 348

Fibrosis, pulmonary, bleomycin-induced (mice), 13

Field, M., see Chang, E. B., 364Filabozzi, P., see Patrignani, P.,

472Fischer, L. J., see Arneric, S. P.,

551Fischli, W., see James, I. F., 88Fitzpatrick, D. B. and Karmazyn,

M.: Comparative effects ofcalcium channel blockingagents and varying extracel-lular calcium concentrationon hypoxia/roeoxygenationand ischemia/reperfusion-in-

duced cardiac injury, 761

Flaim, S. F., see Kanda, K., 711

p-Fluoroamphetamine, corticos-

terones and (rats), 593Forskolin, N-ethylmaleimide and

adenylate cyclase inhibition,425

Fowler, P. J., see Yunger, L. M.,109

FR 34235, ischemia and (dogs),531

Fraser, A., see Lucki, I., 133Fraser, A., see O’Donnell, J. M.,

640Freidnian, E., Yocca, F. D. and

Cooper, T. B.: Anti-depres-sent drugs with varying phar-macological profiles after rat

pineal beta adrenergic-medi-

ated function, 545Freidman, R. L., Barrett, R. J.

and Sanders-Bush, E.: Dis-cniminative stimulus proper-ties of quipazine: Mediationby serotonin2 binding sites,628

Fuhrman-Lane, C., see Sweeney,

E.F., 19Fujimoto, J. M., see Sweeney,

E.F., 19Fung, H.-L., Sutton, S. C. and

Kamiya, A.: Blood vessel up-take and metabolism of or-

ganic nitrates in the rat, 334Funke, E., see Legrum, W., 769

Galzin, A. M., Monet, C. and Lan-

ger, S. Z.: Evidence that ex-ogenous but not endogenous

norepineprhine activates thepresynaptic a�pha-2 adreno-

ceptors on serotonergic nerveendings in the rat hypothal-

814 Index Vol. 228

amus, 725Ganglion

afterdischarge, blockade by ty-ramine (hamsters), 376

sympathetic, aminopyridines

and Ca� (frogs), 573Geller, H. M., see Waterhouse,

B. D., 257

Genetics, polymorphic metabo-lism of encainide (humans),605

Gillette, J. R., see Monks, T. J.,393

Gillis, C. N., see Howell, R. E.,154

Gillis, R. A., see Quest, J. A., 719

Gleason, J. G., see Weichman,B.M., 128

Glick, S. D., see Aguayo, L. G., 80

Gluconeogenesis, hyperglycemiaand a�pha-2 adrenoceptor ag-onists (rats), 168

Glucuronidation, biliary excre-tion and, acetaminophen(rats), 407

Glucuronide, morphine-morphine

pools, Triton X-100 effects(rats), 19

Glucuronyl transferase, liver mor-phine pool effects (rats), 19

Glutathione, conjugation, biliaryexcretion of acetaminophen(rats), 407

Glutathione S-transferase, micro-somal and cytosolic, hexa-chlorobutadiene conjugation(rats), 202

Gomez, B., see Lluch, S., 749Gonzalez, M. C., see Lluch, S., 749GMP, cyclic, see Cyclic GMPGoldstein, A., see James, I. F., 88Green, R. D., see Radulovacki, M.,

268Green, T., see Wolf, C. R., 202Groppetti, A., Parenti, M., Della-

vedova, L. and Tirone, F.:Possible involvement of en-

dogenous opiates in the tol-erance to the anorectic effectof fenfluramine, 446

Gross, G. J. and Warltier, D. C.:Selective improvement in

subendocardial perfusion dis-tal to a flow-limiting coro-nary artery stenosis: Effectsof the new calcium channelblocking agent, FR 34235, ni-fedipine and diltiazem, 531

Gross, G. J., see Lamping, K. A.,

28

Guanabenz, hyperglycemia and(rats), 168

Giudicelli, J.-F., see Cavero, I.,779

Hafez, K., see Catto, B. A., 662Hagiwara, M., Endon, T., Kan-

ayama, T. and Hidaka, H.:Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor ofcyclic GMP phosphodiester-see, on human platelet aggre-gation, 467

Hall, S. and Rowland, M.: Rela-tionship between renal clear-

ance, protein binding andurine flow for digitoxin, acompound of low clearance in

the isolated perfused rat kid-ney, 174

Hallucinogens, raphe unit activityand (cats), 94

Harden, T. K., see Smith, M. M.,

425Hayashi, E., see Yamada, S., 454Hayashi, M., see Yamada, S., 454Heart

adenosine tniphosphatase regu-lation, sympathetic nervous

system and (rats), 304alpha and beta adrenoceptors,

spontaneous hypertension

(rats), 454

AQ-A 39 effects (dogs), 484congestive failure, amrinone

treatment (humans), 319diltiazem and calcium parodox

(rats), 220

injury, calcium and (rats), 761norepinephnine release, nega-

tive feedback control (rats),287

output distribution, nifedipineeffects (rats), 711

Purkinje fibers, isoproterenol-induced electrophysiologicalchanges, adenosine attentua-

tion of (dogs), 792rate, capsaicin-induced changs,

central nervous system site ofaction (cats), 719

rate, hormone effects on (rats),348

rate, pergolide effects (rats),

779

single cell, sodium channel in(rats), 225

Hedner, J., Hed.ner, T., Wessberg,P. and Jonason, J.: Interac-

tion of substance P with therespiratory control system in

the rat, 196Hedner, T., see Hedner, J., 196Hem, D. W. and Weber, W. W.:

Relationship between N-ace-tylator phenotype and sue-ceptibility toward hydrazine-

induced lethal central ner-vous system toxicity in therabbit, 588

Heme oxygenase, inhition, tin-protophorphynin and (rats),327

Hepatocyte

iron-loaded (rats), 676reactive metabolites, bromo-

benzene (rats), 393

Hepatotoxicity, biliary excretion

of acetaminophen (rats), 407Hermiller, J. B., Leithe, M. E.,

Magonien, R. D., Unverferth,D. V. and Leier, C. V.: Amri-none in severe congestiveheart failure: Another look atan intriguing new cardioac-tive drug, 319

Hexachloro-1:3-butadiene, gluta-

thione conjugation of (rats),202

Hidaka, H., see Hagiwara, M., 467Hippocampus, serotonin sensiti-

zation by electroconvulsiveshock (rat), 230

His bundle potentials, cardiacconduction, encainide effects(rabbits, dogs), 180

Histamine, release, basophil,prostaglandin D2 and (hu-man), 400

Hjelle, J. J. and Klaassen, C. D.:Glucuronidation and biliary

excretion of acetaminophenin rats, 407

Hobbs, P. D., see Tyson, C. A.,676

Holtman, J. R., Jr., see Quest,J. A., 719

Holtzman, S. G., see DeRossett,S. E., 669

Hope, W. C., see Welton, A. F., 57Hormone, neurohypophyseal,

cardiovascular control (rats),

348Horn, R., see Durant, N. N., 567

Howell, R. E., Moalli, R. and Gil-lis, C. N.: Analysis of rabbitpulmonary angiotensin con-verting enzyme kinetics invivo, 154

Hudson, A. R., see Magos, L., 478Huidobro-Toro, J. P., Zhu, Y.-X.,

Lee, N. M., Loh, H. H. andWay, E. L.: Dynorphin inhi-bition of the neurotensincontractile activity on themyentenic plexus, 293

Hogestdtt, E. D., and Andersson,K.-E.: Mechanism behind thebiphasic contractile response

to potassium depolarizationin isolated rat cerebral arter-ies, 187

Hogstedt, S., see Rane, A., 774Hydrazine, toxicity, acetylator

status and (rabbits), 58812-Hydroxyeicosatetraenoic acid,

myocardial salvage and

(dogs), 510

5-Hydroxytryptamine, release, at-

pha-2 adrenoceptor agonists

and (rats), 725

5-Hydroxytryptophan, kidney in-fusion with, serotonin for-mation (rats), 53

Hyman, A. L., see Edwards, J. C.,33

Hyperemia, reactive, calciumblockers in ischemia (dogs),

531

Hyperglycemia

atpha-2 adrenoceptor agonists

and (rats), 168dopamine agonist-induced

(rats), 551

Hypersensitivity, immediate, an-tiallergic agent Pu 22-3747(rats), 57

Hypertension

dopamine receptor activation,kidney (rat), 161

spontaneous, bromocniptine de-pressor mechanism (rats),370

spontaneous, cardiac atpha andbeta adrenoceptors (rats), 454

Hypothalamus, serotonergic

nerve endings, a�pha-2 adre-

noceptor activation on (rats),

725

Hypoxia, reoxygenation and, cal-

cium and cardiac injury(rats), 761

Ibuprofen, renal prostaglandin

excretion and (dogs, swine),560

Ichida, S., Moriyama, M. andTerao, M.: Characteristics ofCa influxes through voltage-and receptor-operated Cachannels in ut2nine smooth

muscle, 439Ignarro, L. J., Burke, T. M.,

Wood, K. S., Wolin, M. S.

and Kadowitz, P. J.: Associ-ation betwen cyclic GMPaccmulation and acetylcho-line-elicited relaxation of bo-vine intrapulmonary artery,682

Ignarro, L. J., see Edwards, J. C.,

33

Ileumciguatoxin on (guinea pigs), 756selectivity of dynorphin pep-

tides (guinea pigs), 88Imipramine, chronic, pineal func-

tion (rats), 545Immunoglobulin, G and E, airway

contraction (guinea pigs),

116

Indolapril, CI-907, antihyperten-sive effects (guinea pigs), 312

Inotropy, positive, amrinone incongestive heart failure (hu.mans), 319

Intestinesecretion, opiate withdrawal

and (rats), 364transport, opiate withdrawal

and (rats), 364

Intrapulmonary artery

cyclic GMP and vasodilatation(cows), 33

relaxation, cyclic GMP accu-mulation and (cows), 682

lodocyanopindolol, binding, beta

adrenoreceptors, bladder de-trusor muscle (rabbit), 283

Ion flux, intestinal, opiate with-drawal and (rats), 364

Ionic channels, bicyclo-octane an-alogs on (frogs), 73

Ionic selectivity, sodium channel,single heart cells (rats), 225

Ionophore, Fe(III), iron overloadreduction and (mice), 676

Iprindole, chronic, pineal func-

tion (rats), 545Iron, overload, ionophore-poly-

menic chelators in (mice), 676Ischemia

calcium blockers in (dogs), 531myocardial, digoxin toxicity

and (cats), 537myocardial segment function,

nifedipine effects (dogs), 28reperfusion and, calcium and

cardiac injury (rats), 761

Ishima, T., see Yamada, T., 454Isoniazid, toxicity,acetylator sta-

tue and (rabbits), 588Isoproterenol

510

1984 Index 815

adenylate cyclase, propafenonebeta blockade (humans), 461

electrophysiological changes

induced by, adenosine atten-uation of (dogs), 792

Isosorbide-5-mononitrate, phar-macokinetics (dogs), 235

Itskovitz, H. D., see Stier, C. T.,Jr., 53

James, I. F., Fischli, W. and Gold-stein, A.: Opioid receptor se-lectivity of dynorphin geneproducts, 88

Jandhyala, B. S., see Lokhand-wala, M. F., 696

Jonason, J., see Hedner, J., 196Jorulf, H., see Rane, A., 774Joy, R. M., see Albertson, T. E.,

620Jusko, W. J., see Shum, L., 380

Kadowitz, P. J., see Edwards, J.C., 33

Kadowitz, P. J., see Ignarro, L. J.,682

Kagey-Sobotka, A., see Peters,S. P., 400

Kaloyanides, G. J., see Pastoniza-

Munoz, E., 65Kamiya, A., see Fung, H.-L., 334Kanaide, H., see Meno, H., 220Kanaya, S. and Katzung, B. G.:

Effects of diltiazem on trans-membrane potential and cur-rent of right ventricular pap-illary muscle of ferrets, 245

Kanayama, T., see Hagiwara, M.,

467

Kanda, K. and Flaim, S. F.: Ef-fects of nifedipine on totalcardiac output distribution inconscious rat, 711

Kaplan, H. R., see Ryan, M. J.,312

Kappas, A., see Drummond, G. S.,

327

Karmazyn, M., see Fitzpatrick,

D. B., 761Katzung, B. G., see Kanaya, S.,

245Kawada, M., Satoh, K. and Taira,

N.: Analyses of the cardiacaction of the bradycardicagent, AQ-A 39, by use of iso-lated blood-perfused dog-heart preparations, 484

Ketansenin, sympatholytic action(cats), 704

4-Keto niridazole, central nervoussystem toxicity (rats), 662

6-Ketoprostaglandin F,,,, dazoxi-

ben effects (humans), 472Kidney

carcinogen, glutathione conju-

gation of hexachlorobuta-diene (rats), 202

clearance, digitoxin and (rats),174

clearance, netilmicin (rats), 65function and ultrastructure, al-

kylating agent effects on(dogs), 799

lipoxygenase and arachidonicacid (dogs), 140

metabolite, cimetidine transport

(chickens), 387nonblood-perfused, serotonin

formation (rats), 53prostaglandin excretion, sulin-

dec and (dogs, swine), 560thromboxane, dazoxiben on

(humans), 472transport, inhibition (mon-

keys), 252transport, netilmicin (rats), 65tubule, cimetidine disposition

(chickens), 387

tubule, felodipine site of action(rats), 420

vascular resistance, serotoninformation (rats), 53

Killam, K. F., Jr., see Slikker, W.,Jr., 43

Kim, D., Akera, T. and Weaver,L. C.: Role of sympatheticnervous system in ischemia-induced reduction of digoxintolerance in anesthetizedcats, 537

Kivlighn, S. D., see Lokhandwala,

M. F., 696Klaassen, C. D., see Hjelle, J. J.,

407

Klein, D. C., see Matthew, E., 434Kling, L., see Legrum, W., 769

Koechel, D. A., Budd, G. C. andBretz, N. S.: Acute effects ofalkylating agents on canine

renal function and ultra-structure: High-dose etha-crynic acid vs. dihydroetha-

crynic acid and ticrynafen,799

Kowalski, T. E., see Taylor, D. G.,491

K#{252}hnle,H.-F., see Sponer, G., 235Kuraoka, S., see Akaike, N., 225

Langer, S. Z., see Galzin, A. M.,725

Lau, S. S., see Monks, T. J., 393Lamping, K. A. and Gross, G. J.:

Differential effects of intra-venous us. intracoronary ni-fedipine on myocardial seg-ment function in ischemic ca-nine hearts, 28

Lazo, J. S. and Pham, E. T. Pul-monary fate of [3H�bleomy-cm A2 in mice, 13

Leardi, R, see Raiteri, M., 209La Breton, G. C., see Panise, L V.,

240Lee, N. M., see Huidobro-Toro,

J. P., 293Lefevre-Borg, F., see Cavero, I.,

779

Legrum, W., Kling, L. and Funke,E.: Radioisomers of scopa-rone (6,7-dimethoxycou-mann) as a tool for in vivodifferentiation of various

hepatic monooxygenase in-ducers in mice using breathtest technique, 769

Leier, C. V., see Hermiller, J. B.,319

Leithe, M. E., see Hermiller, J. B.,319

Leukocyte, polymorphonuclear,

myocardial infarction (dogs),

Leukotriene

arachidonic acid and renalblood flow (dogs), 140

thromboxane involvement,

bronchoconstriction (guineapigs), 128

LeValley, S. E., see Tyson, C. A.,676

Lewis, R. J. and Endean, R.:Mode of action of ciguatoxinfrom the Spanish mackerelScomberomoru.s commersoni,on the guinea-pig ileum andvan deferens, 756

Lhoste, F., see Cavero, I., 779Lichtenstein, L. M., see Peters,

S. P., 400Lindberg, B., see Rane, A., 774

Lipoxygenasemyocardial salvage (dogs), 510

renal activity, arachidonic acidand (dogs), 140

Livercoma, methanethiol effects

(rats), 103

monooxygenase inducers, sco-

parone radioisomers inbreath analysis (mice), 769

morphine metabolism (rat), 19weight, obesity and (rats), 380

Lluch, S., Conde, M. V., Di#{233}guez,G., Lopez de Pablo, A. L.,Gonzalez, M. C., Estrada, C.and Gomez, B.: Evidence forthe direct effect of vasopres-sin on human and goat cere-bral arteries, 749

Lock, E. A., see Wolf, C. R., 202Loh, H. H., see Huidobro-Toro, J.

P., 293Lokhandwala, M. F. and Steen-

berg, M. L.: Selective activa-tion by LY-141865 and ape-morphine presynaptic dopa-mine receptors in the rat kid-ney and influence of stimu-lation parameters in the ac-tion of dopamine, 161

Lokhandwala, M. F., Kivlighn, S.

D. and Jandhyala, B. S.:Characterization of the neu-rogenic vasodilatation elic-ited by central dopamine re-ceptor stimulation with per-golide, 696

Long, J. P., see Arneric, S. P., 551

Lopez de Pablo, A. L., see Lluch,S., 749

Lucki, I., Nobler, M. S. and Fra-zer, A: Differential actions ofserotonin antagonists on twobehavioral models of seroto-nm receptor activation in therat, 133

Lungangiotensin-converting enzyme

(rabbit), 154bleomycin disposition (mice),

13

Lung, M. A. K. Y. and Wang, J.C. C.: Effects of prostaglan-din E1 on canine nasal vas-

cular and airway resistances,215

Luthin, G. R. and Tabakoff, B.:

Activation of adenylate cy-

clam by alcohols requires thenucleotide-binding protein,

579

Luthin, G. R. and Wolfe, B. B.:Comparison of [3H]pirenze-phine and [3H]quinuclidinyl-benzilate binding to musca-

rinic cholinergic receptors inrat brain, 648

LY-141865, dopamine receptoractivation, kidney (rat), 161

Lysergic acid diethylamide, rapheunit activity and (cats), 94

Maayani, S., see Aguayo, L. G., 80MacGlashan, D. W., Jr., see Pe-

ters, S. P., 400Magorien, R. D., see Hermiller,

J. B., 319

Magos, L., Clarkson, T. W. andHudson, A. R.: Differences inthe effects of selenite and bi-ological selenium on the

chemical form and distribu-tion of mercury after the si-multaneous administration

of HgCl2 and selenium to

rats, 478Mailman, R. B., see Neidzwiecki,

D. M., 636Major, T. C., see Ryan, M. J., 312Maleque, M. A., see Warnick, J.

E., 73

Marchi, M., see Raiteni, M., 209

Marks, B. H., see Anderson, G. F.,283

Matsuki, N., Quandt, F. N., TenEick, R. E. and Yeh, J. Z.:Characterization of the block

of sodium channels byphenytoin in mouse neuro-

blastoma cells, 523

Matsumoto, M. and Riker, W. K.:

Effects of several aminopyni-dines and analogs on the cal-cium dependence of synaptic

transmission, 573

Matthew, E., Parfitt, A. G., Sug-den, D., Engelhardt, D. L.,Zimmerman, E. A. and Klein,D. C.: Benzodiazepines: Ratpinealocyte binding sites and

augmentation of norepineph-

nine-stimulated N-acetyl-transferase activity, 434

Matthews, W. D., see DiTullio, N.W., 169

McCall, R. B. and Schuette, M.R.: Evidence for an alpha-i

receptor-mediated central

sympathoinhibitory action of

ketanserin, 704

McElroy, J. F., Miller, J. M. andMeyer, J. S.: Fenfluramine,p-chloroamphetamine and p-fluoroamphetamine stimula-tion of pituitary-adrenocor-tical activity in rat: Evidencefor differences in site andmechanism of action, 593

McKendall, G., see Slier, C. T.,

Jr., 53McLeod, A. A., Stiles, G. L. and

Shand, D. G.: Demonstration

of beta adrenoceptor block-

816 Index Vol. 228

ade by propafenone hydro-chloride: Clinical pharmaco-logic, radioligand bindingand adenylate cyclase acti-vation studies, 461

McQuinn, R. L., see Cone, E. J.,147

Meno, H., Kanaide, H. and Nak-amura, M.: Effects of dilti-azem on the calcium paradoxin isolated rat hearts, 220

Meptazinol, Mu-I selective opioid

analgesic (rats, mice), 4143-Mercaptopicolinic acid, hyper-

glycemia and (rats), 168Mercuric chloride, HgCl2-biologi-

cal selenium interaction(rats), 478

Mercury selenide, estimation(rats), 478

Mercury, selenium effects on die-tribution (rats), 478

Mertz, T. E., see Ryan, M. J., 312Mescaline, raphe unit activity and

(cats), 94Mesoridazine, potency, striatal

dopamine autoreceptors

(rabbits), 636Metabolite, reactive, hepatocytes,

bromobenzene (rats), 393

Methanethiol, erythrocyte mem-

brane stabilization andNa�,K�-adenosine triphos-

phatase (rats), 103

Methoxamine, hyperglycemia and(rats), 168

5-Methoxydimethyltryptamine,

electroconvulsive shock andhippocampus (rat), 230

5 - Methoxy - N , N - dimethyltryp

tamine, raphe unit activityand (cats), 94

Metiamide, hyperglycemia and(rats), 168

Metoprolol, clearance estimates(monkey), 774

Meyer, J. F., see McElroy, J. F.,593

Microiontophoresis

norepinephrine and benzodi-

azepine action on y-amino-butyric acid inhibition (rats),257

sensitization to serotonin byelectroconvulsive shock

(rats), 230

Miller, D. A., see Welton, A. F.,57

Miller, J. M., see McElroy, J. F.,593

Miller, R. J., see Chang, E. B., 364Minipump, osmotic, presser re-

sponses to carbachol and(rats), 354

Moalli, R., see Howell, R. E., 154Moises, H. C., see Waterhouse,

B. D., 257

Moncada, S., see Mullane, K. M.,510

Monks, T. J., Lau, S. S. and Gil-lette, J. R.: Diffusion of re-active metabolites out of hep-atocytes: Studies with bro-mobenzene, 393

Monooxygenase, hepatic, scopa-

none radioisomers in breath

analysis (mice), 769Moret, C., see Galzin, A. M., 725Morphine

dependence, intestinal fluid ex-change and (rats), 364

isotope dilution effects (rats),19

meptazinol and (rats, mice),414

Mullane, K. M., Read, N.,Salmon, J. A. and Moncada,S.: Role of leukocytes in

acute myocardial infarctionin anesthetized dogs: Rela-tionship to myocardial sal-vage by anti-inflammatorydrugs, 510

Muscleadenosine triphosphatase regu-

lation and sympathetic ner-vous system (rats), 304

bladder detrusor, beta adreno-receptors in (rabbit), 283

cardiac, conduction (rabbits,dogs), 180

papillary, adrenoreceptors andspontaneous hypertension

(rats), 454skeletal, action potentials and

quantal content, phencycli-dine analogs (frogs, crayfish),

80smooth, coronary artery, aden-

osine relaxation (cows), 342smooth, immunoglobulin G-

and E-mediated airway con-traction (guinea pigs), 116

smooth, voltage- and receptor-operated calcium channels,

uterine (rats), 439ventricular papillary, diltiazem

(ferrets), 245ventricular, propafenone beta

blockade (humans), 461My-5445, platelet aggregation in-

hibition by (humans), 467Myocardium

infarction, leukocyte role

(dogs), 510

ischemia, digoxin toxicity and

(cats), 537

segment function, nifedipineand (dogs), 28

ventricular papillary muscle,diltiazem effects (ferrets),245

Nagahama, S., Chen, Y.-F. and

Oparil, S.: Mechanism of the

depressor effect of bromo-criptine in the spontaneouslyhypertensive rat, 370

Nakamura, M., see Meno, H., 220Naloxonazine, meptazinol anal-

gesis and (rats, mice), 414Naloxone

antagonism, selectivity of dy-

norphin peptides (guinea

pigs), 88behavior and (monkey), 669dynorphin blockade of neuro-

tensin excitability and,

myenteric plexus (guinea

pigs), 293spinal opiate receptor systems

(rats), 1

Naltrexone, opiate withdrawaland intestinal fluid exchange

(rats), 364Naproxen, renal prostaglandin

excretion and (dogs, swine),560

Nash, J. A., see Wolf, C. R., 202Nephrotoxicity, glutathione con-

jugation of hexachlorobuta-diene (rats), 202

Nerve, sciatic, phosphodiesteraseinhibition by physostigmine(cats), 656

Nervous system

autonomic, pergolide cardiovas-cular effects (rats), 779

central, capsaicin-induced car-diovascular changes, site ofaction (cats), 719

central, lethal toxicity, acetyla-

tor status and (rabbits), 588central, sympatholytic action of

ketanserin (cats), 704central, toxicity, 4-keto nirida-

sole (rats), 662

sympathetic, adenosine tn-phosphatase regulation and

(rats), 304

sympathetic, ischemia and di-goxin tolerance (cats), 537

Netilmicin, renal transport (rats),65

Neuroblastoma, sodium channelblocking, phenytoin (mice),523

Neuroblaetoma x glioma cell, N-ethylmaleimide and adenyl-ate cyclase inhibition, 425

Neuromuscular junction, stimu-

lated, anticonvulsant effectson (frogs), 121

Neuronforebrain, sensitization to sero-

tonin by electroconvulsive

shock (rats), 230Purkinje, response to a-amino-

butyric acid (rats), 257

Neuronal membrane, alcohol ef-fects on G-protein-adenylatecyclase interaction (mice),579

Neurotensin, contractile activity,dynorphin inhibition of,myenteric plexus (guineapigs), 293

Neurotransmitterregulation, presynaptic musca-

rinic receptors, brain (rats),209

sympathetic, dopamine recep-tor activation, kidney (rats),161

NG1O8-15 neuroblastoma xglioma cell, N-ethylmaleim-ide and adenylate cyclase in-hibition, 425

Niedzwiecki, D. M., Mailman,

R B. and Cubeddu, L. X.:Greater potency of mesori-dazine and sulforidazine

compared with the parent

compound, thioridazine, onstriatal dopamine autorecep-tors, 636

Nifedipine

arterial baroreflexes, calcium

channel inhibition (dogs),491

cardiac output distribution and(rats), 711

intravenous us. intracoronary,myocardial segment function(dogs), 28

ischemia and (dogs), 531

membrane electrical excitabil-

ity, phencyclidine analogsand (frogs, crayfish), SO

potassium depolarization, cere-bral artery (rats), 187

Nimodipine, arterial baroreflexes,

calcium channel inhibition(dogs), 491

Niridazole, major metabolite, cen-tral nervous system toxicity(rats), 662

Nishi, K., see Akaike, N., 225Nitrate, organic, blood vessel up-

take and metabolism (rats),334

Nitrogen oxide, vasodilators con-

taming, intrapulmonary ar-tery relaxation (cows), 33

Nitroglycerin, blood vessel, up-

take and metabolism (rats),334

Nobler, M. S., see Lucki, I., 133Norepinephrine

N-acetyltransferase and, ben-

zodiazepines (rats), 434adenosine tniphosphatase and

sympathetic nervous system

(rats), 304atpha-2 adrenoceptor activa-

tion and 5-hydroxytrypta-mine release (rabbits), 725

a-aminobutynic acid augmen-

tation (rats), 257chronotropy (rabbits, guinea

pigs, rats), 500release, negative feedback con-

trol (rats), 287

sensitization to, electroconvul-

sive shock, hippocampus(rats), 230

Norman, W. P., see Quest, J. A.,719

Nose, vascular and airway resist-ances, prostaglandin E1 ef-fects (dog), 215

Nucleus centralis superior, hallu-cinogens and (cats), 94

Nucleus raphe pallidus, hallucin-

ogens and (cats), 94

Obesity, theophylline disposition(rats), 380

O’Donnell, J. M., Wolfe, B. B. andFrazer, A.: Agonist interac-tions with beta adrenergic re-

ceptors in rat brain, 640O’Donnell, M., see Welton, A. F.,

57O’Donnell, S. R. and Wanstall,

J. C.: Beta-i and beta-2 ad-renoceptor-mediated re-sponses in preparations ofpulmonary artery and aorta

from young and aged rats,733

Okada, T., see Yamada, S., 454Olszewski, B. J., see Ryan, M. J.,

312

1984 Index 817

Oparil, S., see Nagahama, S., 370

Opiateagonista and antagonists, be-

havior and (monkeys), 669agonists and antagonists, kin-

died amygdaloid seizures and(rats), 620

alkaloids, dynorphin inhibition

of neurotensin excitability,myenteric plexus (guineapigs), 293

dependence and withdrawal, in-

testinal fluid exchange and(rats), 364

endogenous, fenfluramine tol-erance and (rats), 446

receptor, N-ethylmaleimideand adenylate cyclase inhi-bition, 425

receptor, meptazinol (rats,mice), 414

receptor, selectivity of dynor-phin peptides (guinea pigs),88

receptor, spinal (rats), 1Opiopeptins, neurotensin con-

tractile activity inhibition,

myenteric plexus (guinea

pigs), 293

ORG. 6368, neuromuscular block-ing agent, effect on end-plateconductance (frogs), 567

Oxytocin, central cardiovasculareffects (rats), 348

Oyama, Y., see Akaike, N., 225

Pain, visceral, spinal opioid re-ceptors (rats), 1

Pancreas, endocrine, dopamineanalog-induced hyperglyce-mia (rats), 551

Papaverine, membrane action po-tentials, chronotropy, inhibi-tion (rabbits, guinea pigs,rats), 500

Parenti, M., see Groppetti, A., 446Parfitt, A. G., see Matthew, E.,

434

Panise, L. V., Venton, D. L andLa Breton, G. C.: Arachi-donic acid-induced plateletaggregation is mediated by athromboxane A2/prostaglan-din H2 receptor interaction,240

Pasternak, G. W., see Spiegel, K.,414

Paetoniza-Munoz, E., Timmer-man, D. and Kaloyanides, G.J.: Renal transport of netil-micin in the rat, 65

Patrignani, P., Filabozxi, P., Ca-

tella, F., Pugliese, F. and Pa-trono, C.: Differential effectsof dazoxiben, a selectivethromboxane-synthase in-

hibitor, on platelet and renalprostaglandin - endoperox-

ide metabolism, 472Patrono, C., see Patrignani, P.,

472

Peptide, dynorphin, opioid recep-tor selectivity (guinea pigs),

88Pergolide

cardiovascular effects (rats),

779

central inhibition of neurogenictone by (dogs), 696

Peters, S. P., Kagey-Sobotka, A.,MacGlashan, D. W., Jr. andLichtenstein, L. M.: Effect ofprostaglandin D2 in modulat-ing histamine release fromhuman basophils, 400

Pham,E.T.,seeLazo,J.S., 13

Pharmacokinetics, isosorbide-5-mononitrate (dogs), 235

Phencyclidineactive and inactive analogs,

membrane electrical excita-

bility and (frogs, crayfish), 80derivatives, structure-activity

relationship (rats), 147Phenobarbital, neuromuscular

junction and transmitterrelease (frogs), 12i

Phentolamine, hyperglycemiaand (rats), 168

Phenylethylamine, endogenous

noncatecholic, intravenousinjection (dogs), 691

Phenylethylmalonamide, neuro-muscular junction and trans-mitter release (frogs), 121

N6-L-(Phenylisopropyl)adeno-sine, sleep and (rats), 268

Phenytoin, sodium channel block,

neuroblastoma (mice), 523Phosphodiesterase, inhibition by

physostigmine (cats), 656Phosphorylation, protein, coro-

nary arterial smooth muscle(cows), 342

Physostigmine, phosphodiester-

see inhibition by (cats), 656Pineal gland

antidepressant drugs and

(rats), 545benzodiazepine binding sites

(rats), 434Pinealocyte, benzodiazepine

binding sites (rats), 434[3HJPirenzephine, binding, mus-

carinic cholinergic receptors(rats), 648

Plasma, prolactin, bromocriptinedepressor mechanism (rats),370

Plateletaggregation inhibition (hu-

mans), 467aggregation, thromboxane A2-

induced (humans), 240thromboxane, dazoxiben on

(humans), 472Plexus, myenteric, dynorphin

blockade of neurotensin cx-

citability (guinea pigs), 293Polymer, resin, iron overload re-

duction and (mice), 676Polymorphism, genetic, encainide

metabolism (humans), 605Potassium

conductance, phencyclidine an-

alogs and calcium channelblockers (frogs, crayfish), SO

contraction, cerebral artery(rats), 187

transport, renal tubular site ofaction of felodipine (rats),420

Potentialsaction, diltiazem, myocardium

(ferrets), 245action, papaverine (rabbits,

guinea pigs, rats), 500skeletal muscles, phencycidine

analogs and calcium channelblockers (frogs, crayfish), 80

Prazosin, hyperglycemia and(rats), 168

Preussler, D. W., see Trulson, M.

E., 94

Primidone, metabolites, neuro-muscular junction and trans-

mitten release (frogs), 121Prolactin, plasma, bromocriptine

depressor mechanism (rats),

370

Propafenone, beta blockade (hu-mans), 461

Propranolol, hyperglycemia and

(rats), 168Prostaglandin

arachidonic acid and renalblood flow (dogs), 140

excretion, kidney, sulindac and(dogs, swine), 560

Prostaglandin D2, basophil hista-mine release and (human),400

Prostaglandin E1, nasal vascular

and airway resistance (dog),215

Prostaglandin-endoperoxide, me-tabolism, dazoxiben effects(humans), 472

Prostaglandins F2 and D2, effectson bronchoconstniction (gui-nea pigs), 128

Prostaglandin H2, platelet aggre-gation and (humans), 240

Proteinbinding, digitoxin renal clear-

ance and (rats), 174nucleotide-binding, adenylate

cyclase activation by alcoholsand (mice), 579

Protein kinase, cyclic AMP-de-pendent, coronary arterialsmooth muscle (cows), 342

Psilocin, raphe unit activity and(cats), 94

Pugliese, F., see Patrignani, P.,472

Pulmonary artery, beta receptor

mechanisms (rats), 733Pupil, diameter, phencyclidine ef-

fects (rats), 147Purkinje cell, a-aminobutynic

acid inhibition, norepineph-rime and benzodiazepine ef-fects (rats), 257

Purkinje conduction, encainideeffects (rabbits, dogs), 180

Purkinje fiber, isoproterenol-in-

duced electrophysiologicalchanges, adenosine attenua-

tion of (dogs), 792Pyrazinoate, urate excretion

(monkeys), 252Pyridoxyl isonicotinoyl acid hy-

drazone, ionophoretic activ-

ity (rats), 676

Qian, J. Q., see Timmermans, P.

B. M. W. M., 739

Quandt, F. N., see Matsuki, N.,523

Quest, J. A., Dias-Souza, J., Nor-

man, W. P., Holtzman, J. R.,Jr. and Gillis, R. A.: Centralnervous system site of action

of capsaicin-induced cardio-vascular changes in the cat,

719[3HlQuinuclidinylbenzilate, bind-

ing, muscarinic cholinergic

receptors (rats), 648Quipazine, discriminative prop-

erties, serotonin binding and(rats), 628

Radioisomer, scoparone, breathanalysis (mice), 769

Radulovacki, M., Virus, R. M.,

Djuricic-Nedelson, M. and

Green, R. D.: Adenosine an-alogs and sleep in rats, 268

Raiteri, M., Leardi, R. and Mar-chi, M.: Heterogeneity of pro-synaptic muscarinic recep-

tors regulating neurotrans-mitter release in the ratbrain, 209

Randolph, A. E., see Ryan, M. J.,312

Rane, A., Hogstedt, S., Kindberg,B., Reg#{226}rdh, C.-G. and Jo-rulf, H.: Comparison of dif-

ferent clearance estimates formetoprolol in the rhesusmonkey, 774

Rardon, D. P. and Bailey, J. C.:Adenosine attenuation of theelectrophysiological effects ofisoproterenol on canine car-diac Purkinje fibers, 792

Rauwolscine

hyperglycemia and (rats), 168selectivity and potency, alpha-

1 and atpha-2 adenoceptorantagonists (rats), 739

Read, N., see Mullane, K. M., 510Receptor

alpha-i, sympatholytic action

of ketanserin (cats), 704

a�pha-2 adrenergic, regulation

(rats, pigs), 275beta adrenergic, agonist inter-

actions (rats), 640beta adrenergic, antidepressant

drugs and pineal function(rats), 545

beta adrenergic, bladder detru-son muscle (rabbit), 283

calcium channels operated by(rats), 439

dopamine, activation in kidney

(rats), 161dopamine, stimulation with

pergolide (dogs), 696kappa, selectivity of dynorphin

peptides (guinea pigs), 88

modulated, diltiazem, myocar-dium (ferrets), 245

Mu-i, opioid analgesic (rats,mice) 414

muscarinic cholinergic, adenyl-ate cyclase inhibition, 425

muscarinic cholinergic, [3H]pi-renzephine and [3Hjquinucli-dinylbenzilate binding to

818 Index Vol. 228

(rats), 648muscarinic, cyclic GMP (cows),

682muscarinic, spontaneous hy-

pertension (rats), 454nicotinic acetylcholine, bicyclo-

octane analogs on ionic chan-nels (frogs), 73

noradrenergic, adenosine tri-

phosphatase regulation and(rats), 304

opiate, antinociception media-tion by (rats), 1

opiate, N-ethylmaleimide andadenylate cyclase inhibition,425

opiate, meptazinol and (rats,mice), 414

opioid, selectivity of dynorphin

peptides (guinea pigs), 88presynaptic muscarmnic, neuro-

transmitter regulation, brain(rats), 209

serotonin, activation (rats), 133serotonin, quipazine cue and

(rats), 628surface contour, phencyclidine

(rats), 147thromboxane A�prostaglandin

H2, platelet aggregation (hu-man), 240

Regal, J. F.: Immunoglobulin G-and immunoglobulin E-me-diated airway smooth musclecontraction in the guinea pig,116

R.eg#{224}rdh,C.-G., see Rane, A., 774

Renin, bromocriptine depressor

activity, hypertension and(rats), 370

Rennick, B., Ziemniak, J., Smith,

I., Taylor, M. and Acara, M.:Tubular transport and me-tabolism of cimetidine inchicken kidneys, 387

Reoxygenation, hypoxia and, cal-

cium and cardiac injury(rats), 761

Reperfusion, ischemia and, cal-

cium and cardiac injury(rats), 761

Resistance, nasal vascular and

airway, prostaglandin E1 ef-fects (dog), 215

Respiratory duty cycle, substance

Pand (rat), 196Respiratory system

depression, meptazinol and(rats, mice), 414

regulation, substance P and(rats), 196

Richer, C., see Cavero, I., 779Riker, W. K., see Mataumoto, M.,

573

Ro 22-3747, antiallergic agent,immediate hypersensitivitydiseases (rats), 57

Roden, D. M., see Wang, T., 605Rowland, M., see Hall, S., 174ES 21361, selectivity and potency,

alpha-i and alpha-2 adreno-

ceptor antagonists (rats), 739Ruffolo, R. R., Jr., see Timmer-

mans, P. B. M. W. M., 739RX 781094, selectivity and po-

tency, alpha-i and alpha-2

adrenoceptor antagonists(rats), 739

Ryan, M. J., Boucher, D. M.,Cohen, D. M., Essenberg, A.D., Major, T. C., Mertz, T.E., Olszewski, B. J., Ran-dolph, A. E., Singer, R. M.and Kaplan, H. R: Antihy-pertensive effects of CI-907:

A novel nonsulfliydryl angio-tensin converting enzyme in-

hibitor, 312

849 cyC lymphoma cell, N-ethyl-maleimide and adenylate cy-clam inhibition, 425

Sabatier, C., see Cavero, I., 779Salmon, J. A., see Mullane, K. M.,

510Sanders-Bush, E., see Friedman,

R. L., 628Sanguinetti, M. C. and West, T.

C.: Influence of papavenineon spontaneous activity ofisolated right atria fromsmall mammals, 500

Satoh, K., see Kawada, M., 484

Sawin, L. L., see Dibona, G. F.,420

Schmauss, C. and Yaksh, T. L.:In vivo studies on spinal opi-ate receptor systems mediat-ing antinociception. II. Phar-macological profiles suggest-ing a differential associationof mu, delta and kappa recep-tors with visceral chemicaland cutaneous thermal slim-uli in the rat, 1

Schuette, M. R., see McCall, R.B., 704

Scoparone, radioisomers, breathanalysis (mice), 769

Seizure, amygdaloid, opiate an-tagonist and agonist effects(rats), 620

Selenium, mercury effects on dis-tribution (rats), 478

Selenomethionine, effects on

mercury (rats), 478Serotonin

antagonists and receptors acti-

vation (rats), 133binding sites, quipazine cue and

(rats), 628intrarenal formation (rats), 53neurons containing, hallucino-

gens and raphe unit activity(cats), 94

opiates and, fenfluramine tol-erance (rats), 446

sensitization to, electroconvul-sive shock, hippocampus(rats), 230

Serum, thromboxane B2, dazoxi-

ben effects (humans), 472Setler, P. E., see Yunger, L. M.,

109

Sex differences, theophylline dis-tribution, obesity and (rats),380

Shand, D. G., see McLeod, A. A.,461

Shannon, H. E. and Thompson,W. A.: Behavior maintainedunder fixed-interval and see-

ond-order schedules by intra-

venous injections of endoge-

nous noncatecholic phenyl-ethylamines in dogs, 691

Shannon, H. E., see Cone, E. J.,147

Shock, electroconvulsive, sensiti-ration to serotonin, hippo-

campus (rats), 230Shum, L. and Jusko, W. J.: The-

ophylline disposition in obese

rats, 380Silver, P. J., Walus, K. and Di-

Salvo, J.: Adenosine-medi-ated relaxation and activa-tion of cyclic AMP-depend-ent protein kinase in coro-nary arterial smooth muscle,342

Simionatto, C. S., see Anderson,K. E., 327

Simpson, L. L.: Fragment C oftetanus toxin antagonizes theneuromuscular properties of

native tetanus toxin, 600Singer, R. M., see Ryan, M. J.,

312

Sinoatrial node, cardiac action of

AQ-A 39 (dogs), 484SK&F 88046, mechanism of ac-

tion (guinea pigs), 128Sleep, adenosine analog effects

(rats), 268Slikker, W., Jr., Brocco, M. J. and

Killam, K. F., Jr.: Reinstate-ment of responding main-tamed by cocaine or thiamy-lal, 43

Smith I., see Rennick, B., 387Smith, M. M. and Harper, K.:

Modification of receptor-me-diated inhibition of adenylatecyclase on NG-i0815 neuro-blastoma x glioma cells by N-ethylmaleimide, 425

Sodium, transport, renal tubularsite of action of felodipine(rats), 420

Sodium channelblocking, phenytoin, neuroblas-

toma (mice), 523voltage-dependent single heart

cells (rats), 225Spanish mackerel, ciguatoxin

from, ileum and vas deferens(guinea pigs), 756

Spiegel, K. and Pasternak, G. W.:Meptazinol: A novelMu-i se-

lective opioid analgesic, 414Spinal cord, opiate receptor sys-

tems, antinociception media-tion by (rats), 1

Sponer, G., K#{252}hnle,H.-F., Strom,K., Bartsch, W., Endele, Rand Dietmann, K.: Pharma-cokinetic aspects of isosor-bide-5-mononitrate in dogs,235

Standaert, F. G., see Curley, W.H., 656

Stark, L. G., see Albertson, T. E.,620

Steenberg, M. L., see Lokhand-wala, M. F., 161

Stenosiscoronary artery, calcium block-

ers and (dogs), 531

coronary artery, ischemia

(dogs), 28Stier, C. T., Jr., McKendall, G.

and Itskovitz, H. D.: Seroto-nin formation in nonblood-perfused kidneys, 53

Stiles, G. L., see McLeod, A. A.,461

Storer, B., see DiTullio, N. W.,

169Strein, K., see Sponer, G., 235Stniatum, dopamine autorecep-

tors, thioridazine and (nab-bits), 636

Substance P, respiratory regula-

tion and (rats), 196Sugden, D., see Matthew, E., 434Sulfation, biliary excretion of

acetaminophen (rats), 407

Sulfonidazine, potency, striataldopamine autoreceptors(rabbits), 636

Sulindac, renal prostaglandin ex-cretion and (dogs, swine), 560

Sutton, S. C., see Fung, H.-L., 334Swann, A. C.: (Na�,K�)-Adeno-

sine tniphosphatase regula-tion by the sympathetic ncr-vous system: Effects of nor-adrenergic stimulation andlesions in vivo, 304

Sweeney, E. F., Fuhrman-Lane,C. and Fujimoto, J. M.: Mor-phine-morphine glucuronidepools in the rat liver: EffectsofTriton X-100, 19

Sympathetic nervous system, seeNervous system

Synaptosomes, superfused, neu-rotransmitter regulation(rats), 209

Tabakoff, B., see Luthin, G. R.,579

Taira, N., see Kawada, M., 484Talbot, P. A. and Alderdice,

M. T.: Effects of pnimidone,phenobarbital and phenyle-

thylmalonamide in the stim-ulated frog neuromuscularjunction, 121

Taylor, D. G. and Kowalski, T. E.:Comparison of calcium chan-nd inhibitors on vagal heartrate responses elicited by ar-tenial baroreceptor reflexes inanesthetized dogs, 491

Taylor, M., see Rennick, B., 387

Ten Eick, R. E., see Matsuki, N.,523

Terao, M., see Ichida, S., 439Tetanus, toxin, fragment C, neu-

romuscular blocking and(mice), 600

Theophylline, disposition, obesity

(rats), 350Thiamylal, responding main-

tamed by, reinstatement(monkeys), 43

Thionidazine, dopamine autore-

ceptors and (rabbits), 636Thompson, W. A., see Shannon,

H. E., 691

Thromboxaneeffects on bronchoconstriction

1984 Index 819

(guinea pigs), 128platelet and renal, dazoxiben

effects (humans), 472Thromboxane A2, platelet aggre-

gation and (humans), 240Ticrynafen, renal function and ul-

trastructure (dogs), 799Timmerman, D., see Pastoriza-

Munoz, E., 65Timmermans, P. B. M. W. M.,

Qian, J. Q., Ruffolo, R. R., Jr.and van Zwieten, P. A.: Astudy of the selectivity andpotency of rauwolscine, RX781094 and RS 21361 as an-

tagonists of alpha-i and at-

pha-2 adrenoceptors, 739Tin-protoporphyrin, tissue distri-

bution and disposition,(rats), 327

Tirone, F., see Groppetti, A., 446Tomita, T., see Yamada, S., 454Toxin, tetanus, fragment C, neu-

romuscular blocking and(mice), 600

Trachea, sensitivity and respon-siveness, calcium antagonistsand (guinea pigs), 612

Transmitterrelease, anticonvulsant effects

on (frogs), 121

release, sympathetic, presyn-aptic control (rats), 287

Transmural nerve, stimulation,

isolated atria (rabbits, guineapigs, rats), 500

Transport, see specific type andsite

Triton X-iOO, liver (rats), 19Trulson, M. E., Preussler, D. W.

and Trulson, V. M.: Differ-ential effects of hallucino-genic drugs on the activity ofserotonin-containing neu-

rons in the nucleus centralissuperior and nucleus raphepallidus in freely movingcats, 94

Trulson, V. M., see Trulson, M.E.,94

Tyramine, ganglionic afterdis-charge blockade by (ham-sters), 376

Tyson, C. A., LeValley, S. E.,Chan, R, Hobbs, P. D. andDawson, M. I.: Biologicalevaluation of some iono-

phore-polymeric chelatorcombinations for reducingiron overload, 676

Unverferth, D. V., see Hermiller,

J. B., 319Urate, excretion, p-aminohippur-

ate and pyrazinoate effects(monkey), 252

Urineflow, digitoxin renal clearance

and (rats), 174thromboxane B2, dazoxiben ef-

fects (humans), 472Uterus, smooth muscle, voltage-

and receptor-operated cal-cium channels (rats), 439

Valencia, C. I., see Catto, B. A.,662

van Zwieten, P. A., see Timmer-mans, P. B. M. W. M., 739

Vas deferens, ciguatoxin on(guinea pigs), 756

Vasodilatationcyclic GMP and (cows), 682

neurogenic, central inhibitionby pergolide (dogs), 696

Vasodilator, nitrogen oxide-con-taming intrapulmonary ar-tery relaxation (cows), 33

Vasopressin

central cardiovascular effects

(rats), 348cerebral vessels (humans,

goats), 749pressor responses to carbachol

(rats), 354Vasotocin, central cardiovascular

effects (rats), 348Venton, D. L., see Panise, L. V.,

240Ventricle, automaticity, AQ-A 39

effects (dogs), 484Verapamil

arterial baroreflexes, calciumchannel inhibition (dogs),491

chronotropic effects (rabbits,guinea pigs, rats), 500

membrane electrical excitabil-

ity, phencyclidine analogsand (frogs, crayfish), 80

Virus, R. M., see Radulovacki, M.,

268Vitamin B6, deficiency, isoniazid

toxicity and acetylator status

(rabbits), 588

Wakade, A. R. and Wakade, T.D.: Reduction in norepineph-rime content of sympatheticneuroeffector organs by alpha

adrenergic antagonists andnerve stimulation: Evidencefor presynaptic control of

sympathetic transmitter re-lease in intact animal, 287

Wakade, T. D., see Wakade, A.R., 287

Walus, K., see Silver, P. J., 342Wang, J. C. C., see Lung, M. A.

K. Y., 215

Wang, T., Roden, D. M., Wolfen-den, H. T., Woosley, R. L.,Wood, A. J. J. and Wilkin-son, G. R.: Influence of ge-netic polymorphism on themetabolism and disposition

of encainide in man, 605Wanstall, J. C., see O’Donnell,

S. R., 733Warfanin, scoparone radioisomers

in breath analysis (mice), 769Warltier, D. C., see Gross, G. J.,

531

Warnick, J. E., Maleque, M. A.and Albuquerque, E. X.: In-teractions of bicyclo-octane

analogs of amantadine withionic channels of the nico-tinic acetylcholine receptorand electrically excitablemembrane, 73

Wannick, J. E., see Aguayo, L. G.,80

Wasserman, M. A., see Weich-man, B. M., 128

Water, deprivation, arachidonicacid and renal blood flow(dogs), 140

Waterhouse, B. D., Moises, H. C.,Yeh, H. H., Geller, H. M. andWoodward, D. J.: Compari-son of norepinephrine- andbenzodiazepine-induced aug-mentation of Purkinje cell re-

sponses to a-aminobutynic

acid (GABA), 257Way, E. L., see Huidobro-Toro,

J. P., 293Weaver, L. C., see Kim, D., 537Weber, W. W., see Hem, D. W.,

558Webster, L. T., Jr., see Catto, B.

A., 662

Wei, E. T., see Wu, Y. Y., 354Weichman, B. M., Wasserman,

M. A. and Gleason, J. G.:SK&F 88046: A unique phar-macologic antagonist of

bronchoconstriction inducedby leukotniene D4, thrombox-ane and prostaglandins F�and D2 in vitro, 126

Weinstein, H., see Aguayo, L. G.,80

Welton, A. F., Hope, W. C.,O’Donnell, M., Baruth, H.,Crowley, H. J., Miller, D. A.and Yaremko, B.: Ro 22-3747: A new antiallergic

agent for the treatment ofimmediate hypersensitivitydiseases, 57

Wessberg, P., see Hedner, J., 196West, T. C., see Sanguinetti, M.

C., 500Wilkinson, G. R., see Wang, T.,

605Wolf, C. R, Berry, P. N., Nash,

J. A., Green, T. and Lock, E.A.: Role of microsomal andcytosolic glutathione S-transferases in the conjuga-

tion of hexachloro-1:3-buta-diene and its possible role-

vance to toxicity, 202

Wolfe, B. B., see Luthin, G. R.,648

Wolfe, B. B., see O’Donnell, J. M.,640

Wolfenden, H. T., see Wang, T.,605

Wolin, M. S., see Ignarro, L. J.,

682Wood, A. J. J., see Wang, T., 605Wood, K. S., see Ignarro, L. J.,

682Woodward, D. J., see Waterhouse,

B. D., 257

Woosley, R. L., see Wang, T., 605Wu, Y. Y. and Wei, E. T.: Mech-

anisms underlying the pros-son responses to acute and

chronic intraventnicular ad-ministration of carbachol in

the rat, 354

Yaksh, T. L., see Schmauss, C., 1

Yamada, S., Ishima, T., Tomita,T., Hayashi, M., Okada, T.and Hayashi, E.: Alterationsin cardiac alpha and beta ad-renoceptors during the devel-

opment of spontaneous hy-pertension, 454

Yaremko, B., see Welton, A. F.,57

Yatani, A., see Akaike, N., 225Yeh, H. H., see Waterhouse, B.

D., 257

Yeh, J. Z., see Matsuki, N., 523Yocca, F. D., see Friedman, E.,

545Yohimbine, hyperglycemia and

(rats), 168Yunger, L. M., Fowler, P. J., Zar-

evics, P. and Setlen, P. E.:Novel inhibitors of a-amino-butyric acid (GABA) uptake:Anticonvulsant actions in

rats and mice, 109

Zambraski, E. J., Chremos, A. N.

and Dunn, M. J.: Comparisonof the effects of sulindac withother cycbooxygenase inhibi-tors on prostaglandin excre-tion and renal function innormal and chronic bile duct-ligated dogs and swine, 560

Zarevics, P., see Yunger, L. M.,109

Zenbe, R L., see Feuerstein, G.,348

Zhu, Y.-X., see Huidobro-Toro, J.P., 293

Ziemnak, J., see Rennick, B., 387Zimmerman, E. A., see Matthew,

E., 434

Zitaglio, T., see Christ, D., 376