INDEX

Volume 252, January-March, 1990

A-64662, renin inhibition, renal hemody-namic and excretory responses (mon-

keys), 449Aass, H., see Skomedal, T., 853Abed, J. F., see Gruber, S. A., 733Abraham, R. T., see Oakes, S. G., 979Abrahamsson, T., see Nerme, V., 1341Acara, M., see Lohr, J., 154Acetaminophen

hepatotoxicity, methylxanthines, induc-

tion states (rats), 112

intestinal glucuronidation and sulfation

(rats), 201metabolites, altered hepatobiliary dispo-

sition, phenobarbital pretreatment(rats), 657

Acetylcholine

basal release, muscarinic receptor block-ade (rats), 739

contractile response to bombesin, longi-tudinal muscle, ileum (guinea pigs),339

inhibition of contractions but not relaxa-

tions, pertussis toxin, pulmonary ar-tery (rabbits), 260

rate perfusion pressure, substance P(guinea pigs), 179

release, inhibition from neocortex, co-con-otoxin GVIA (humans), 778

N-Acetyl--y-glutamyl prodrug, renal selec-tivity,1255

Adeagbo, A. S. 0., Breen, C. A., Cutz, E.,Lees, J. G., Olley, P. M. and Coceani,F.: Lamb ductus venosus: Evidenceof a cytochrome P-450 mechanism inits contractile tension, 875

Adeagbo, A. S. 0. and Malik, K. U.: Mech-anism of vascular actions of prosta-

cyclin in the rat isolated perfusedmesenteric arteries, 26

Adenine nucleosides, nucleotides and, nerve

and drug-induced release, aorta (rab-bits), 1060

Adenosine, angiotensin II and, vasocon-strictor response, hypertonic saline

infusions (dogs), 631

Adenosine monophosphate, cyclic, seeCyclic AMP

Adenylate cyclasebeta-2 adrenoceptor-mediated vasodila-

tion, aorta, clenbuterol treatment(rats), 758

coupling, beta adrenoceptor binding, pul-monary artery vs. aorta (rats), 86

desimipramine and lithium, serotonergicreceptor number, second messenger

function in brain (rats), 826

inhibition, muscarinic receptor subtypes,

myometrium (guinea pigs), 800intracellular cyclic AMP content, chronic

ethanol exposure, PC 12 cells, 1021mouse neuroblastoma x rat glioma hybrid

cells, cAMP accumulation, musca-

rinic cholinergic receptors, 616

prolonged reserpine treatment, adapta-

tive mechanisms, dopamine Dl and

D2 receptors (mice), 810

role of membrane lipid order, tetrahydro-

cannabinol, heart (rats), 1075Adham, N., see Blue, D. R., 1034Adler, M. W., see Tiseo, P. J., 539Adrenal medulla, effect of quinpirole, sym-

pathoadrenal system (dogs), 770Adrenoceptors

alphaaging, norepinephrine release (rats),

159

sympathetic control, proximal urethra(rats), 706

alpha-2, evidence for G-protein precou-pling (cows), 1184

alpha-2 Aadenylate cyclase coupling, pulmonary

artery vs. aorta (rats), 86antagonist characterization, ileum

(guinea pigs), 1034characterization, fats cells (humans),

312 betaG,-coupling, isoproterenol (guinea

pigs), 1341neural adaptation, imipramine (rats),

997prenatal propanolol exposure, fetal and

neonatal lung (rats), 42supersensitivity, right atria in early

sepsis (rats), 675beta-2, vasodilation in aorta, clenbuterol

(rats),758Adrenocorticotropic hormone, plasma,

fourth cerebroventricle, nicotine(rats), 623

AG-1749, inhibition of acid formation,mechanism, parietal cells (dogs),

1289Aging

ethanol consumption and, muscarinic

cholinergic receptors, brain (rats),869

prejunctional modulation, norepineph-rine release (rats), 159

-related changes in relaxant response,atrial natriuretic peptide, vascular

smooth muscle (rats), 1234Ahmad, S. and Ward, P. E.: Role of amino-

peptidase activity in the regulation of

the pressor activity of circulating an-giotensins, 643

Airwaypotassium channel activator, excitatory

noncholinergic and cholinergic neu-rotransmission (guinea pigs), 1207

potentiation of nonadrenergic neural re-

laxation, cAMP phosphodiesteraseinhibitor (guinea pigs), 396

Albumin, intratubular, furosemide-A mech-

anism, diuretic resistance in ne-

phrotic syndrome (rats), 1097

Albuquerque, E. X., see Costa, A. C. S., 507Albuquerque, E. X., see Kofuji, P., 517Alcohol, castration-induced changes in re-

sponse, hypothalamic-pituitary axis(rats), 456

Aldosterone, carbon tetrachloride-induced

cirrhosis (rats), 438

Alkaloids, Veratrum, nerve stimulation, iontransport in jejunum (mice), 636

Allen, C. N., see Bigornia, L., 586Allergy, dual antagonist, platelet-activating

factor and histamine, SCH 37370(guinea pigs), 1090

Allografts, renal model, pharmacodynamics,

local heparin infusion (dogs), 733Aiprenolol, antagonist characterization,

atypical beta adrenoceptors (guineapigs), 1034

Althaus, W. A., see Lindstrom, T. D., 1117Amiloride, imidazoline-guanidinium recep-

tive site, renal proximal tubule (rab-

bits), 293Amine, neural adaptation, imipramine,

forced swim test (rats), 997

-y-Aminobutyric acid

antagonism of GABAA receptor, amino--y-carbolines (mice), 1269

contractile response to bombesin, longi-tudinal muscle, ileum (guinea pigs),

339evoked release from striatal neurons,

NMDA receptor system (mice), 380Amino--y-carbolines, antagonism of -y-ami-

nobutyric acidA receptor (mice), 1269

p-Aminohippurate, transport in brush bor-der membrane, kidney (pigs), 792

Aminopeptidase, regulation of pressor activ-

ity, circulating angiotensins, 643

D-Amphetamine, fenfluramine and, toler-

ance, food intake (baboons), 960Analgesia

differential release, substance P and so-matostatin, spinal cord (rats), 539

E-2078 (mice), 1247morphine withdrawal

mu antagonist and kappa agonist prop-erties of �-funaltrexamine (rats),

1006SCH 23390 labeling, dopamine D1 re-

ceptors (rats), 901 spinal

Anatoxin-a, acetylcholine receptor-ion

channel, activation and blockade

(frogs),517Anderson, D. C., see Shappell, S. B., 531Anderson, J., see Malfroy, B., 462Anesthesia, urethane, duodenal motility,

cholecystokinin-octapeptide (rats),

1312

Angiogenesis, basement membrane biosyn-

thesis, target, tumor therapy, 753Angiotensin-converting enzyme, inhibitors,

biliary excretion, conjugation (rats),1202

Angiotensin IIadenosine and, vasoconstrictor response,

hypertonic saline infusions (dogs),

631-induced contractions, endogenous pros-

1387

1388 Index Vol. 252

taglandins, cerebral and mesenteric

arteries (dogs, monkeys), 374mechanism of action, proximal tubular

transport (rats), 689

tachyphylaxis to vasoconstrictor effect,arachidonic acid, kidney (rats), 241

Angiotensins, circulating, regulation ofpressor activity, aminopeptidase, 643

Anion, tachykinin-induced secretion, distal

colon (guinea pigs), 1Ansari, M. A., see Elias, A. N., 384Antidepressants

binding sites in brain (rats), 410

desimipramine and lithium, serotonergicreceptor number, second messengerfunction in brain (rats), 826

Antihypertensive agents, DuP 753, nonpep-

tide angiotensin II receptor antago-

nists (rats), 711, 719, 726Antinociception

inhibition of tail-flick response, f3-endor-

phin, morphine (rats), 546

parathyroid hormone peptide fragments,salmon calcitonin, morphine (mice),140

Aorta

adenylate cyclase coupling, beta adreno-ceptor binding (rats), 86

alpha-2 receptors, receptor G-protein cou-pling (cows), 1184

beta-2 adrenoceptor-mediated vasodila-tion, clenbuterol treatment (rats),

758

endothelial cells, cyclic GMP production,bradykinin (porcine), 581

nerve and drug-induced release, adeninenucleosides, nucleotides (rabbits),

1060receptor-mediated mutual-effect amplifi-

cation, phenylephrine and serotonin(rabbits), 500

thromboxane A2/prostaglandin H2 recep-

tor, vasoconstrictor response, endo-thelin (rats), 915

Aoyama, T., see Relling, M. V., 442Aracava, Y., see Costa, A. C. S., 507

Aracava, Y., see Kofuji, P., 517Arachidonic acid

indomethacin effects on neural and my-ogenic components, airway smoothmuscle (horses), 358

tachyphylaxis to vasoconstrictor effect,kidney (rats), 241

Arendt, J., see Welch, S. P., 370Arginine vasopressin, carbon tetrachloride-

induced cirrhosis (rats), 438Aronstam, R. S., see Costa, A. C. S., 507Aronstam, R. S., see Kofuji, P., 517Arrhythmia, cocaine-mediated impairment,

cardiac conduction (dogs), 185Artery

cerebral, endothelium-dependent vaso-

constriction, membrane depolariza-tion (cats), 93

cerebral and mesenteric, endogenousprostaglandins, angiotensin Il-in-

duced contractions (dogs, monkeys),374

contraction, Rb-86 efflux, BRL-34915(rats), 51

coronary

binding and functional studies, musca-rinic cholinoceptors (porcine), 765

calcium channel receptor sites, PN 200-110 (pigs), 327

endothelium effects, basal tone and ag-

onist (pigs), 1053

5-hydroxytryptamine-induced endo-thelium-dependent relaxation (pigs),

387receptor systems, epidermal growth fac-

tor-urogastrone (porcine, bovine),

1277

different tissues, 5-HT2 receptor hetero-geneity (rats, rabbits), 1083

inositol phosphate production, effect ofH-7, crossbridge phosphorylation

(rabbits), 253mesenteric

mechanism of vascular actions, prosta-

cyclin (rats), 26

smooth muscle sensitivity, calcium an-

tagonists (rabbits), 1167

pimobendan effects (rats), 1304pulmonary

adenylate cyclase coupling, beta adre-noceptor binding (rats), 86

endothelin-induced contractions, pina-

cidil antagonism (guinea pigs, rats),

1318

inhibition of contractions, pertussis

toxin (rabbits), 260

Na7K�-adenosine triphosphatase,monocrotaline (rats), 70

Arthritis, biologic properties of romazarit

(rats), 1331

Ashby, C. R., Jr., Jiang, L. H., Kasser, R. J.and Wang, R. Y.: Electrophysiologi-

cal characterization of 5-hydroxytryptamine2 receptors in therat medial prefrontal cortex, 171

Assays, spectrophotometric and biological,nitric oxide endothelium-derived re-

laxing factor, 922Asthma, potassium channel activator, excit-

atory noncholinergic and cholinergicneurotransmission (guinea pigs),

1207Atlas, D., see Coupry, I., 293Atria, right, supersensitivity, beta adre-

noceptors (rats), 675

Atrial natriuretic peptide

age-related changes in relaxant response,vascular smooth muscles (rats), 1234

carbon tetrachloride-induced cirrhosis

(rats), 438

cyclooxygenase products, modulation ofrenal response, endothelin (rats),1213

Atropine, rate perfusion pressure, substance

P (guinea pigs), 179Austin, M. C. and Kalivas, P. W.: Enke-

phalinergic and GABAergic modula-

tion of motor activity in the ventral

pallidum, 1370Autoradiography

antidepressant binding sites in brain(rats), 410

cellular localization of serotonin 1A,1B,cingulate cortex, uptake sites (rats),

651peripheral type benzodiazepine receptors,

lung (guinea pigs), 880

Ayaziki, K., see Toda, N., 374Azepexole, halothane and, pertussis toxin

effect (guinea pigs), 1156

Bachenheimer, L. C., see Jam, R. K., 147

Baker, R. C., Tucker, M. and Clay, K. L.:Ethanol inhibits zymosan-stimulated

and enhances nonstimulated plate-let-activating factor production in a

clonal macrophage cell line, 1028

Baister, R. L., see Beardsley, P. M., 953Barker, L. A., Winbery, S. L., Smith, L. W.

and McDonough, K. H.: Supersensi-tivity and changes in the active pop-

ulation of Beta adrenoceptors in ratright atria in early sepsis, 675

Barnes, P. J., see Chilvers, E. R., 786

Barnes, P. J., see Ichinose, M., 1207Barnes, P. J., see Mak, J. C. W., 880Barnes, P. J., see Rhoden, K. J., 396Barnette, M. S., Grous, M., Torphy, T. J.

and Ormsbee, H. S., III: Activation

of cyclic AMP-dependent protein ki-nase during canine lower esophageal

sphincter relaxation, 1160

Barrington, P. L. and Ten Eick, R. E.: Char-

acterization of the electrophysiologi-

cal effects of metoprolol on isolatedfeline ventricular myocytes, 1043

Basement membrane, biosynthesis, target,

tumor therapy, 753Bass, P., see Herman, J. R., 135

Batty, I. H., see Chilvers, E. R., 786

Baughman, R., see Malfroy, B., 462Beardsley, P. M., Hayes, B. A. and Balster,

R. L.: The self-administration ofMK-801 can depend upon drug-rein-forcement history and its discrimi-

native stimulus properties are phen-cyclidine-like in rhesus monkeys, 953

Behavior

drug-reinforcement history, self-adminis-

tration, MK-801 (monkeys), 953

enhanced sensitivity, naltrexone (rats), 8

low-dose caffeine discrimination (hu-mans), 970

phencyclidine-like, NMDA-induced con-

vulsions, NMDA and glycine antag-onists (mice), 349

smoked marijuana effects, tobacco ciga-rette smoking behavior (humans),

934

thermoregulatory set point, opioid ago-nists (rats), 696

Benet, L. Z., see Smith, P. C., 218Benzamide, sodium-dependent isomeriza-

tion, dopamine D-2 receptors, epide-

pride, 1108

Benzimidazole, inhibition of acid formation,AG-1749, parietal cells (dogs), 1289

Benzodiazepines, midazolam, tolerance and

physical dependence (rats), 1125

Berlan, M., see Galitzky, J., 312Bestatin, transport mechanisms, intestinal

brush-border membranes (rabbits),859

Betaine, disposition of choline, dimethylam-inoethanol, kidney (rats), 154

Bhargava, H. N. and Gulati, A.: Modifica-tion of brain and spinal cord dopa-

mine D1 receptors labeled with [3H]SCH 23390 after morphine with-drawal from tolerant and physically

dependent rats, 901

Bicarbonate, water secretion, gabexate and

camostat, pancreas (dogs), 320Bigornia, L., Allen, C. N., Jan, C.-R., Lyon,

R. A., Titeler, M. and Schneider, A.S.: D2 dopamine receptors modulate

calcium channel currents and cat-

echolamine secretion in bovine adre-

nal chromaffin cells, 586

1990 Index 1389

Bilder, G. E., Kasiewski, C. J. and Perrone,M. H.: Phorbol-12,13-dibutyrate-in-duced vasoconstriction in Vivo:Characterization of response in ge-netic hypertension, 526

Biliary excretion, conjugation and, diacid

angiotensin-converting enzyme in-

hibitors (rats), 1202

Billah, M. M., Chapman, R. W., Egan, R.W., Gilchrest, H., Piwinski, J. J.,Sherwood, J., Siegel, M. I., West, R.

E., Jr. and Kreutner, W.: Sch 37370:A potent, orally active, dual antago-nist of platelet-activating factor andhistamine, 1090

Bitran, J. A., see Gusovsky, F., 466Bjur, R. A., see Sedaa, K. 0., 1060Blanchard, S. M., see Kabas, J. S., 185Blood pressure, mediation of tachycardia, 5-

hydroxytryptamine, receptors (dogs),683

Bloom, A. S., see Hillard, C. J., 1075Bloxham, D. P., Bradshaw, D., Cashin, C.

H., Dodge, B. B., Lewis, E. J., West-macott, D. and Self, C. R.: Biologicproperties of Romazarit (Ro 31-

3948), a potential disease-modifyingantirheumatic drug, 1331

Blue, D. R., Bond, R. A., Adham, N., Del-mendo, R., Michel, A. D., Elgen, R.M., Whiting, R. L. and Clarke, D. E.:Antagonist characterization of “atyp-

ical” beta adrenoceptors in guinea pigileum: Blockade by alprenolol and

dihydroalprenolol, 10, 34Boarder, M. R., see Plevin, R., 1296Boisse, N. R., Quaglietta, N., Samoriski, G.

M. and Guarino, J. J.: Tolerance andphysical dependence to an ultra-

short-acting benzodiazepine, mida-zolam, 1125

Bombesin, mechanism of contractile re-sponse, longitudinal muscle, ileum

(guinea pigs), 339

Bond, R. A., see Blue, D. R., 1034Boulanger, C., see Schini, V. B., 581

Bowers, R. J., see Shubat, P. J., 70Boyer, D. R., see Hillard, C. J., 1075Bradshaw, D., see Bloxham, D. P., 1331Brady, J. V., see Kelly, T. H., 934Bradycardia, rate perfusion pressure, sub-

stance P (guinea pigs), 179Bradykinin

cyclic GMP production, B2 kinin recep-tors, aortic endothelial cells (por-

cine), 581esophageal longitudinal smooth muscle

(opossums), 1012

Brainactivation of ventral medullary serotonin

receptor subtypes, cardiovascular ac-

tivity (cats), 665

antidepressant binding sites (rats), 410

basal acetyicholine release, muscarinic re-

ceptor blockade (rats), 739cingulate cortex, cellular localization, Se-

rotonin 1A,1B (rats), 651dopamine D receptors, SCH 23390 label-

ing, morphine withdrawal (rats), 901dopaminergic and serotonergic mecha-

nisms, SCH 23390 and haloperidol(rats), 845

5-HT1, receptors, G -protein-linked sero-tonin receptors, kidney (mice), 1347

hypothalamic-pituitary axis, castration-induced changes, alcohol (rats), 456

medial prefrontal cortex, characteriza-tion, 5-hydroxytryptamine2 receptors(rats), 171

modulation of mesoprefrontal dopamine

neurons, central benzodiazepine re-

ceptors, 989

muscarinic cholinergic receptors, ethanol

consumption and aging (rats), 869role of fourth cerebroventricle, plasma

ACTH responses, nicotine (rats), 623second messenger function, serotonergic

receptor number, desimipramine and

lithium (rats), 826

substantia nigra and nucleus caudate,neurotensin-induced dopamine re-

lease (rabbits), 817

synaptosomes, sodium-dependent release,dopamine and noradrenaline (rats),1283

ventral pallidum, enkephalinergic and

GABAergic modulation, motor activ-

ity (rats), 1370

Branch, R. A., see Deray, G., 631Brater, D. C., see Kirchner, K. A., 1097Breeding, M., see Sanders-Bush, E., 984Breen, C. A., see Adeagbo, A. S. 0., 875Breese, G. R., Criswell, H. E., McQuade, R.

D., Iorio, L. C. and Mueller, R. A.:Pharmacological evaluation of SCH-

12679: Evidence for an in Vivo antag-onism of D1-dopamine receptors, 558

Breese, G. R., see Paul, I. A., 997Bremazocine, differential cross-tolerance,

shock titration schedule (monkeys),

845Bridenbaugh, R., see Malfroy, B., 462

BRL 34915, see CromakalimBronchoconstriction, inhibition of reflex,

airway opioid receptors (guinea pigs),863

Brosnihan, K. B., see Chatelain, R. E., 117Brouwer, K. L. R. and Jones, J. A.: Altered

hepatobiliary disposition of acetami-nophen metabolites after phenobar-

bital pretreatment and renal ligation:Evidence for impaired bilary excre-tion and a diffusional barrier, 657

Brown, D. R., Overend, M. F. and Treder,

B. G.: Neurohormonal regulation ofion transport in the porcine distaljejunum. Actions of somatostatin-14and its natural and synthetic homo-logs, 126

Brush-border membrane

intestinal, transport mechanisms, besta-tin (rabbits), 859

urate and p-aminohippurate transport,kidney (pigs), 792

vesicles, peptidases and peptide transport(rats), 98

Buchholz, J. and Piper Duckles, S.: Effectof age on prejunctional modulation of

norepinephrine release, 159

Buckner, C. K., Fedyna, J. S., Robertson, �J.

L., Will, �J. A., England, D. M., Krell,R. D. and Saban, R.: An examinationof the influence of the epithelium oncontractile responses to peptidoleu-

kotrienes and blockade by ICI 204,219 in isolated guinea pig trachea andhuman intralobar airways, 77

Buckpitt, A., see Plopper, C., 428Buja, L. M., see Shaul, P. W., 86

Burke, B. A., see Gruber, S. A., 733Burks, T. F., see Sheldon, R. J., 636Burks, T. F., see Spencer, R. L., 696Burton, C. K., Ho, I. K. and Hoskins, B.:

Evidence for involvement of cyclicGMP phosphodiesterase in morphinetolerance, 104

BW942C, kappa opioid partial agonist activ-ity (humans, rats, mice, monkeys),225

Caffeine, low-dose, discrimination (hu-

mans), 970Calcitonin, morphine and, parathyroid hor-

mone peptide fragments, antinoci-

ceptive tests (mice), 140Calcitonin gene-related peptide, -containing

nerves, vascular adrenergic neuro-

transmission (rats), 403Calcium

antagonists, sensitivity, mesenteric arterysmooth muscle (rabbits), 1167

displacement, catamphiphilic drug up-

take, erythrocytes and muscular tis-sue (humans), 333

intracellular, block by doxorubicin,neuroblastoma cells, 979

maitotoxin-stimulated phosphoinositide

breakdown, mechanism, HL-60 cells,

466mechanisms of vascular action, parathy-

roid hormone, 840nonpeptide angiotensin II receptor antag-

onists, DuP 753 (rats), 711, 719, 726pertussis toxin and vasomotion (rabbits),

260phospholipase C, modulation of automa-

ticity, cardiac Purkinje fibers (dogs),886

sodium-dependent release of dopamine,

noradrenaline, brain synaptosomes

(rats), 1283

Calcium channelantagonists, mechanisms, gastric proton

pump inhibition (rabbits), 1102

dihydropyridine antagonists, antiseizureactivity (rats), 1150

glycine-evoked neurotransmitter release,hippocampus (rats), 574

inhibition of norepinephrine and acetyl-choline release, co-conotoxin GVIA,neocortex (humans), 778

modulation of current, D2 dopamine re-ceptors, adrenal chromaffin cells (bo-

vine), 586potent blocking action of chiorpromazine,

neuroblastoma cells (mice), 1142

receptor sites, PN 200-110, coronary ar-

tery (pigs), 327Calcium current, cromakalim actions on

ionic currents, portal vein, smooth

muscle cells (rats), 832

Caliezi, A., see Scheurer, U., 1324Camostat, gabexate and, water and bicar-

bonate secretion, pancreas (dogs),

320Campbell, E. D., see Gennings, C., 208Canafax, D. M., see Gruber, S. A., 733Capsaicin

calcitonin gene-related peptide-contain-

ing nerves, vascular adrenergic neu-rotransmission (rats), 403

-induced miosis in eye, prevention, recom-

binant enkephalinase (rabbits), 462Captopril, vasoconstrictor response, angio-

1390 Index Vol. 252

tensin II and adenosine, hypertonicsaline infusions (dogs), 631

Carbolines, antagonism of -y-aminobutyric

acidA receptor, amino--y -carbolines(mice), 1269

Cardiovascular system

activation, ventral medullary serotoninreceptor subtypes (cats), 665

cocaine effects, central and autonomicneural mechanisms (monkeys), 491

Carini,D.J.,seeChiu,A.T., 711

Carini, D. J., see Wong, P. C., 719, 726Carlen, P. L., see Reynolds, J. N., 265Carter, W. H., Jr., see Gennings, C., 208Cashin, C. H., see Bloxham, D. P., 1331Cass, W. A., see Lupica, C. R., 1134Castration, -induced changes in response to

alcohol, hypothalamic-pituitary axis

(rats), 456

Catamphiphilic drugs, uptake into erythro-cytes and muscular tissue, calciumdisplacement, phosphatidylserine

monolayers (humans), 333

Catecholamineeffect of quinpirole on sympathoadrenal

system (dogs), 770

secretion, D2 dopamine receptors, adrenalchromaffin cells (bovine), 586

Cations, organic, transport by kidney epi-

thelial cells, 286

Caudle, R. M. and Chavkin, C.: Mu opioidreceptor activation reduces inhibi-

tory postsynaptic potentials in hip-pocampal CA3 pyramidal cells of rat

and guinea pig, 1361Cavero, I., see Le Monnier de Gouville, A.

C., 300Cavero, I., see Tahraoui, L., 1221Cephalosporins, renal mitochondrial toxic-

ity (rabbits), 65Cephradine, intestinal brush-border mem-

brane, transport mechanisms, besta-tin (rabbits), 859

Cerebellar granule cells, glutamate-induced

neuronal death (rats), 419CGS 21680, electrophysiology, cAMP for-

mation, hippocampus and striatum(rats), 1134

CGS 19281A, antihypertensive effects(rats),117

Chan, Y. L., see Wang, T., 689Chao, C. C., Sharp, B. M., Pomeroy, C.,

Filice, G. A., and Peterson, P. K.:

Lethality of morphine in mice in-

fected with Toxoplasma gondii, 605Chapman, R. W., see Billah, M. M., 1090Chatelain, R. E., Manniello, M. J., Dardik,

B. N., Rizzo, M. and Brosnihan, K.B.: Antihypertensive effects of CGS19281A, an inhibitor of phenyletha-nolamine-N-methytransferase, 117

Chavkin, C., see Caudle, R. M., 1361Chekal, M. A., see Verburg, K. M., 449Cheng, H.-Y., see Hoke, G. D., 908Chiba, S., see Horiuchi, A., 320Chilvers, E. R., Batty, I. H., Barnes, P. J.

and Nahorski, S. R.: Formation ofinositol polyphosphates in airwaysmooth muscle after muscarinic re-ceptor stimulation, 786

Chiu, A. T., McCall, D. E., Price, W. A.,Wong, P. C., Carini, D. J., Duncia, J.

V., Wexler, R. R., Yoo, S. E., John-son, A. L. and Timmermans, P. B.M. W. M.: Nonpeptide angiotensin II

receptor antagonists. VII. cellular

and biochemical pharmacology ofDuP 753, an orally active antihyper-tensive agent, 711

Chiu, A. T., see Wong, P. C., 719, 726Chloride, contractile responses, ethanol and

GABAA agonists, ileum longitudinalmuscle (guinea pigs), 474

Chlorpromazine, potent blocking action,

calcium channels, neuroblastomacells (mice), 1142

Cholecystokinin-octapeptide, dual effectson duodenal motility, urethane anes-thesia (rats), 1312

Choline, disposition in kidney, dimethylam-inoethanol (rats), 154

Cholinoceptors, muscarinic, binding andfunctional studies, coronary artery(porcine), 765

Choroid plexus, serotonin,� receptor reserve,receptor subsensitivity (rats), 984

Chow, Y.-K., see Viamonte, V. M., 886Christ, G. J., Goldfarb, J. and Maayani, S.:

Receptor-mediated mutual-effectamplification elicited by phenyleph-

rine and serotonin in isolated rabbitaorta, 500

Chromaffin cellsadrenal, D2 dopamine receptors, calcium

channel currents (bovine), 586noradrenalin release, phosphoinositide

turnover, cAMP accumulation, 1296

Ciaranello, R. D., Tan, G. L. and Dean, R.:

G-protein-linked serotonin receptors

in mouse kidney exhibit identicalproperties to 5-HTh receptors inbrain, 1347

Cicero, T. J., Greenwald, J., Nock, B. and

O’Connor, L.: Castration-inducedchanges in the response of the hypo-thalamic-pituitary axis to alcohol inthe male rat, 456

Cigarette smokingeffect of nicotine dose, withdrawal-

suppression (humans), 1175

tobacco, smoked marijuana effects, be-

havior (humans), 934Cingulate cortex, cellular localization of Se-

rotonin 1A,1B, uptake sites (rats),651

Cipkus-Dubray, L. A., see Meisheri, K. D.,1167

Cipolle, R. J., see Gruber, S. A., 733Cirrhosis, carbon tetrachloride-induced,

atrial natriuretic peptide, vasopressin

and aldosterone (rats), 438Clara cells, bronchiolar necrosis from naph-

thalene, lung (mice), 428

Clarke, D. E., see Blue, D. R., 1034Clarke, D. E., see Craig, D. A., 1378Clay, K. L., see Baker, R. C., 1028Clenbuterol, beta-2 adrenoceptor-mediated

vasodilation, aorta (rats), 758Clonidine, imidazoline-guanidinium recep-

tive site, renal proximal tubule (rab-bits), 293

Cocaine

cardiovascular effects, central and auto-nomic neural mechanisms (mon-keys), 491

-mediated impairment of cardiac conduc-tion (dogs), 185

potentiation of cardiac effects, neurallyreleased norepinephrine (cats), 147

Coceani, F., see Adeagbo, A. S. 0., 875

Coene, M. -C., see van Wauwe, J. P., 365Coffman, W. J., see Wilson, H., 683

Cohen, M. L., see Wilson, H., 683Cold, noxious, differential release, sub-

stance P and somatostatin (rats), 539Colon

different motor actions, dynorphins,kappa opioid receptor agonists (rats),1324

distal, tachykinin-induced anion secre-tion (guinea pigs), 1

Colpaert, F. C., see Koek, W., 349Cone, E. J., see Vaupel, D. B., 225co-Conotoxin GVIA, inhibition of norepi-

nephrine and acetylcholine release,neocortex (humans), 778

Convulsions, NMDA-induced, NMDA and

glycine antagonists (mice), 349Cooke, H. J., see Kuwahara, A., 1

Cools, W., see van Wauwe, J. P., 365Coma, D., see Vigan#{244},G., 344Costa, A. C. S., Swanson, K. L., Aracava,

Y., Aronstam, R. S. and Albuquerque,E. X.: Molecular effects of dimethy-lanatoxin on the peripheral nicotinicacetylcholine receptor, 507

Costa, E., see Manev, H., 419Cough, inhibition, airway opioid receptors

(guinea pigs), 863

Coupry, I., Atlas, D., Podevin, R.-A., Uzielli,

I. and Parini, A.: Imidazoline-guani-dinium receptive site in renal proxi-

mal tubule: Asymmetric distribution,regulation by cations and interaction

with an endogenous clonidine dis-

placing substance, 293

Coward, D. M., Dixon, A. K., Urwyler, S.,

White T. G., Enz, A., Karobath, M.and Shearman, G.: Partial dopamine-agonistic and atypical neurolepticproperties of the amino-ergolinesSDZ 208-911 and SDZ 208-912, 279

Cox, R. H.: Effects of putative K� channelactivator BRL-34915 on arterial con-traction and �RB efflux, 51

Craft, R. M. and Dykstra, L. A.: Differentialcross-tolerance to opioids in squirrelmonkeys responding under a shocktitration schedule, 945

Cragoe, E. J., Jr., see Jagadeesh, G., 1184Craig, D. A. and Clarke, D. E.: Pharmaco-

logical characterization of a neuronal

receptor for 5-HT in guinea pig ileumwith properties similar to the 5-HT4

receptor, 1378

Creatine kinase, cardioprotective effects ofsodium nitrite, myocardial ischemia,reperfusion (cats), 35

Crino, P. B., Vogt, B. A., Volicer, L. and

Wiley, R. G.: Cellular localization ofserotonin 1A, lB and uptake sites incingulate cortex of the rat, 651

Criswell, H. E., see Breese, G. R., 558Cromakalim

actions on ionic currents, single smoothmuscle cells, portal vein (rats), 832

arterial contraction and Rb-86 efflux,BRL-34915 (rats), 51

excitatory noncholinergic and cholinergicneurotransmission, airways (guineapigs), 1207

renal hemodynamics and function (dogs),

1240

Cubeddu, L. X., see Faggin, B. M., 817

Cutz, E., see Adeagbo, A. S. 0., 875

1990 Index 1391

Cyclic AMPaccumulation, phosphoinositide turnover,

noradrenalin release from adrenalchromaffin cells, 1296

adenylate cyclase activity, chronicethanol exposure, PC 12 cells, 1021

adenylate cyclase coupling, beta adreno-ceptor binding, pulmonary artery vs.aorta (rats), 86

-dependent protein kinase, activation,lower esophageal sphincter relaxa-

tion (dogs), 1160formation and dopamine release, CGS

21680 effects on electrophysiology,hippocampus and striatum (rats),1134

mechanisms of vascular action, parathy-roid hormone, 840

mouse neuroblastoma x rat glioma hybridcells, muscarinic cholinergic recep-

tom, 616neurohormonal regulation of ion trans-

port, distal jejunum (pigs), 126ontogeny of cortical muscarinic receptor

subtypes (rats), 482phosphodiesterase inhibitor, nonadre-

nergic neural relaxation, airway

(guinea pigs), 396Cyclic GMP

attenuation of vascular relaxation, cyclo-sporin A (rats), 165

stimulation of production by bradykinin,B2 kinin receptors, aortic endothelialcells (porcine), 581

Cyclic GMP phosphodiesterase, morphinetolerance (rats), 104

Cyclooxygenase, modulation of renal re-

sponse, atrial natriuretic peptide, en-

dothelin (rats), 1213Cyclosporin A, vascular relaxation and

cyclic GMP responses (rats), 165Cytochrome P-450

bronciolar Clara cell necrosis, naphtha-lene, lung (mice), 428

CYP2C subfamily, tolbutamide, mephen-ytoin hydroxylation (humans), 442

inhibitors, metabolism, all-trans-retinoicacid (rats), 365

mechanism in contractile tension, ductusvenosus (lambs), 875

Dadan, J., , see Perico, N., 1213Daly, J. W., see Gusovsky, F., 466Daniase-Michel, C., Montastruc, J.-L.,

Gharib, C., Geelen, G., de Saint-Blanquat, G. and Tran, M.-A.: Effectof quinpirole, a specific dopamineDA2 receptor agonist on the sympa-thoadrenal system in dogs, 770

Dardik, B. N., see Chatelain, R. E., 117Dean, R., see Ciaranello, R. D., 1347de Costa, B. R., see France, C. P., 600Delmendo, R., see Blue, D. R., 1034Denervation, chronic, electrophysiology, ad-

renergic neurotransmission (dogs),1197

de Paulis, T., see Nerve, K. A., 1108Deray, G., Sabra, R., Herzer, W. A., Jack-

son, E. K. and Branch, R. A.: Inter-action between angiotensin II andadenosine in mediating the vasocon-

strictor response to intrarenal hyper-

tonic saline infusions in the dog, 631

Dermorphin, respiratory and locomotorstimulation (rats), 235

de Saint-Blanquat, G., see Damase-Michel,C., 770

Desimipramine, lithium and, serotonergicreceptor number, second messengerfunction in brain (rats), 826

Deth, R. C., see Jagadeesh, G., 1184Dewey, W. L., see Welch, S. P., 140Dextrorphan, blockade of voltage-depend-

ent potassium currents, phencycli-dine, thymocytes (mice), 610

Diaphragm, activation of ventral medullaryserotonin receptor subtypes, cardio-vascular activity (cats), 665

Digoxin, inhibition of electrogenic Na�-pumping, atrial tissue (humans), 60

Dihydroalprenolol, antagonist characteriza-tion, atypical beta adrenoceptors(guinea pigs), 1034

Dihydropyridine, calcium channel antago-nists, antiseizure activity (rats), 1150

Diltiazemcatamphiphilic drug uptake, calcium cbs-

placement, erythrocytes and muscu-lar tissue (humans), 333

gastric proton pump inhibition, calciumchannel antagonists (rabbits), 1102

Dimethylaminoethanol, disposition of cho-

line in kidney (rats), 154

Dimethylanatoxin, molecular effects, pe-

ripheral nicotinic acetylcholine re-

ceptor, 5072,3-Diphosphoglycerate phosphatase/syn-

thase, elevation of diphosphoglycer-ate level, red blood cells (humans),192

Discrimination, low-dose caffeine (hu-

mans), 970Discriminative stimulus, phencyclidine-like

properties, self-administration, MK-801 (monkeys), 953

Diuresis

renal hemodynamics and function, cr0-makalim effects (dogs), 1240

resistance in nephrotic syndrome, furo-

semide-A, intratubular albumin(rats), 1097

Dixon, A. K., see Coward, D. M., 279Dodge, B. B., see Bloxham, D. P., 1331Doleial, V. and Wecker, L.: Muscarinic re-

ceptor blockade increases basal ace-tylcholine release from striatal slices,739

Domurat, E. S., see Elias, A. N., 384Dooley, D. J., see Feuerstein, T. J., 778Dopamine

-agonistic and neuroleptic properties,SDZ 208-911 and SDZ 208-912 (rats),279

mesoprefrontal neurons, modulation, cen-tral benzodiazepine receptors, 989

neurotensin-induced release, substantia

nigra, nucleus caudate (rabbits), 817release in hippocampus and striatum,

CGS 21680 effects, electrophysiology(rats), 1134

sodium-dependent release, noradrenaline,

brain synaptosomes (rats), 1283Doxorubicin, blockade of increase in intra-

cellular calcium, neuroblastoma cells,

979Drack, E., see Scheurer, U., 1324Drieman, J. C., Thijssen, H. H. W., Struy-

ker-Boudier, H. A. J.: Renal selectiveN-acetyl--y-glutamyl prodrugs. II.Carrier-mediated transport and in-

tracellular conversion as determi-nants in the renal selectivity of N-acetyl--y-glutamyl sulfamethoxazole,1255

Drummer, D., see Newman, M. E., 826Drummer, 0. H., Nicolaci, J. and Sakovidis,

D.: Biiary excretion and conjugationof DI-acid angiotensin-converting

enzyme inhibitors, 1202Ductus venosus, cytochrome P-450 mecha-

nism, contractile tension (lambs),875

Duncan, G. E., see Paul, I. A., 997Duncia, J. V., see Chiu, A. T., 711Duncia, J. V., see Wong, P. C., 719, 726Dunwiddie, T. V., see Lupica, C. R., 1134DuP 753, nonpeptide angiotensin II recep-

tsr antagonists (rats), 711, 719, 726Dykstra, L. A., see Craft, R. M., 945Dynorphin A, differential release, substance

P and somatostatin, spinal cord(rats), 539

Dynorphinsanalgesia produced by E-2078 (mice),

1247nonpeptide kappa opioid receptor agonists

and, different motor actions, colon(rats), 1324

E-2078, analgesia (mice), 1247Egan, R. W, see Billah, M. M., 1090Eglen, R. M., see Blue, D. R., 1034Eicosanoids

cytochrome P-450 mechanism in con-tractile tension, ductus venosus

(lambs), 875

thromboxane A2/prostaglandin H2 recep-tsr, endothelin, aorta (rats), 915

Electrophysiologyadrenergic neurotransmission, chronic

denervation, saphenous veins (dogs),1197

effects of CGS 21680, cAMP formation,hippocampus and striatum (rats),1134

effects of metoprolol, ventricular myo-cytes (cats), 1043

Elias, A. N., Vaziri, N. D., Domurat, E. S.,Pandian, M. R., Ansari, M. A. andYazdani, M.: Atrial natriuretic pep-tide; arginine vasopressin, aldoste-rone and plasma renin activity in car-bon tetrachloride-induced cirrhosisin rats, 384

Ellinwood, E. H., see Kabas, J. S., 185Enalapril, biliary excretion and conjugation

(rats), 1202$-Endorphin, -induced inhibition, tail-flick

response, mechanisms (rats), 546Endothelial cells, aortic, cyclic GMP pro-

duction, bradykinin (porcine), 581

Endothelin-induced contractions of smooth muscle,

pinacidil antagonism, lungs (guineapigs, rats), 1318

modulation of renal response, cyclooxy-genase products, atrial natriureticpeptide (rats), 1213

thromboxane A2/prostaglandin H2 recep-tor, vasoconstrictor response, aorta(rats), 915

Endothelin-1, hemodynamic and pharma-

cological evaluation, vasodilator andvasoconstrictor effects (rats), 300

Endothelium

1392 Index Vol. 252

basal tone and agonist, oxygen sensitivity,coronary artery (pigs), 1053

binding and functional studies, musca-rinic cholinoceptors, coronary artery(porcine), 765

-dependent modulation of vasoconstric-tion, membrane depolarization, cere-bral arteries (cats), 93

-dependent relaxation

5-hydroxytryptamine-induced, coro-nary arteries (pigs), 387

pertussis toxin, pulmonary artery (rab-bits), 260

endogenous prostaglandins, angiotensinIl-induced contractions, cerebral andmesenteric arteries (dogs, monkeys),374

mechanism of vascular actions, prostacy-din, mesenteric arteries (rats), 26

Endothelium-derived relaxing factor

cardioprotective effects, sodium nitrite,myocardial ischemia (cats), 35

nitric oxide, spectrophotometric and bio-logical assays, 922

Enero, M. A., see Kazanietz, M. G., 758England, D. M., see Buckner, C. K., 77English, J., see Welch, S. P., 370enhanced capacity of PGEI receptors to

stimulate cAMP accumulation, 616Enkephalin, GABAergic modulation of mo-

tor activity, ventral pallidum (rats),

1370Enkephalinase, recombinant, prevention,

capsaicin-induced miosis in eye (rab-bits), 462

Enz, A., see Coward, D. M., 279Epidepride, sodium-dependent isomeriza-

tion, dopamine D-2 receptors, 1108Epidermal growth factor, -urogastrone, cor-

onary artery receptor systems (por-cine, bovine), 1277

Epithelia, W-secreting, inhibition of acidi-fication, prostaglandin F� (frogs),929

Epithelial cells, renal, oxytocin stimulation,phosphoinositide hydrolysis, 552

Epithelium, contractile responses to pepti-doleukotrienes, blockade by IC! 204,219 (guinea pigs), 77

Erythrocytes, uptake of catamphiphilicdrugs, calcium displacement, phos-phatidylserine monolayers (humans),333

Esophaguslongitudinal smooth muscle, bradykinin

effect (opossums), 1012lower, sphincter relaxation, cAMP-de-

pendent protein kinase (dogs), 1160Esterase, inhibition, zomepirac glucuronide

disposition, plasma protein binding(guinea pigs), 218

17$-Estradiol, uremic bleeding (rats), 344Ethanol

chronic exposure of PC 12 cells, adenylatecyclase activity, cAMP content, 1021

consumption and aging, muscarinic cho-linergic receptors, brain (rats), 869

GABAA agonists and, contractile re-

sponses, ileum longitudinal muscle

(guinea pigs), 474inhibition of zymosan-stimulated PAF

production, clonal macrophage cellline, 1028

tolerance in hippocampal neurons (rats),265

Ethanol/chloral hydrate, isobolographic

characterization, drug interactions,biological variability (mice), 208

Ethylhexanol, 02-dependent hepatotoxicity,

mitochondria, liver (rats), 1355Ethylketazocine, differential cross-toler-

ance, shock titration schedule (mon-keys), 845

Evans, S. M., see Griffiths, R. R., 970Eye, capsaicin-induced miosis, prevention,

recombinant enkephalinase (rab-bits), 462

Eylers, J. P., see Kudlacz, E. M., 42

Faggin, B. M., Zubieta, J. K., Rezvani, A.H. and Cubeddu, L. X.: Neurotensin-induced dopamine release in Vivoand in Vitro from substantia nigraand nucleus caudate, 817

Fat cells, a�pha-2 A adrenoceptor character-ization (humans), 312

Fauth, C., see Fouda, A.-K., 286Favaron, see Manev, H., 419Fedyna, J. S., see Buckner, C. K., 77Fenfluramine, D-amphetamine and, toler-

ance, food intake (baboons), 960Fenwick, J. W., see Hughes, J. R., 1175Feuerstein, G., see Paakkari, P., 235Feuerstein, T. J., Dooley, D. J. and Seeger,

W.: Inhibition of norepinephrine andacetylcholine release from humanneocortex by w-conotoxin GVIA’, 778

Filice, G. A., see Chao, C. C., 605Fincher, A. S., see Frye, G. D., 474Fiorica-Howells, E., Gambale, F., Horn, R.,

Osses, L. and Spector, S.: Phencycli-

dine blocks voltage-dependent potas-sium currents in murine thymocytes,610

Fischman, M. W., see Kelly, T. H., 934Fisher, S. K., see Thompson, A. K., 744Flavahan, N. A., see Komori, K., 1197Flawia, M. M., see Rubinstein, M., 810Floch, A., see Tahraoui, L., 1221Flunarizine, catamphiphilic drug uptake,

calcium displacment, erythrocytesand muscular tissue (humans), 333

Foegh, M. L., see Rego, A., 165Foltin, R. W., see Kelly, T. H., 934Foltin, R. W.: Differential development of

tolerance to the effects of d-amphet-amine and fenfluramine on food in-

take in baboons, 960Formalin, transmission of nociceptive infor-

mation, substance P and somato-statin, spinal cord (mice), 1261

F#{246}rstermann, U., see Hohlfeld, J., 260Fouda, A.-K., Fauth, C. and Roch-Ramel,

F.: Transport of organic cations bykidney epithelial cell line LLC-PK,,286

Foy, B., see Hrdina, P. D., 410France, C. P., de Costa, B. R., Jacobson, A.

E., Rice, K. C. and Woods, J. H.:Apparent affinity of opioid antago-

nists in morphine-treated rehesusmonkeys discriminating between sa-

line and naltrexone, 600Frye, G. D., Fincher, A. S., Lorenzetti, M.,

Trzeciakowski, J. and Griffith, W.H.: Comparison of contractile re-sponses of the guinea pig ileum lon-gitudial muscle to ethanol and GA-BAA agonists, 474

Fujimoto, S. and Matsuda, T.: Effects of

pimobendan, a cardiotonic and vaso-dilating agent with phosphodiester-ase inhibiting properties, on isolatedarteries and veins of rats, 1304

Fujiwara, M., see Okada, M., 1283�3-Funaltrexamine, mu and kappa agonist

properties, spinal analgesia (rats),1006

Furosemide-A, mechanism for diuretic re-

sistance, intratubular albumin, ne-phrotic syndrome (rats), 1097

Furukawa, 0., see Takeuchi, K., 1228Furuya, Y., see Nakazawa, T., 1247

Gabanelli, M., see Perico, N., 1213Gabexate, camostat and, water and bicar-

bonate secretion, pancreas (dogs),

320Gainey Matta, S., McAllen, K. M. and

Sharp, B. M.: Role of the fourth cer-ebroventricle in mediating rat plasma

ACTH responses to intravenous nic-otine, 623

Galitzky, J., Larrouy, D., Berlan, M. andLafontan, M.: New tools for humanfat cell Alpha-2A adrenoceptor char-acterization. Identification on mem-branes and on intact cells using the

new antagonist [3H]RX821002, 312Gambale, F., see Fiorica-Howells, E., 610Gan, B. S. and Hollenberg, M. D.: Distinct

coronary artery receptor systems forepidermal growth factor-urogastrone,1277

Ganapathy, V., see Miyamoto, Y., 98Gangliosides, glutatmate-induced neuronal

death, cerebellar granule cells (rats),

419Garattini, S., see Vigan#{224},G., 344Garg, L. C., Wozniak, M. and Phillips, M.

I.: Stimulation of phosphoinositidehydrolysis by oxytocin in renal epi-

thelial cells, 552Geelen, G., see Dainase-Michel, C., 770Gennings, C., Carter, W. H., Jr., Campbell,

E. D., Staniswalis, J. G., Martin, T.J., Martin, B. R., and White, K. L.,Jr.: Isobolographic characterizationof drug interactions incorporating bi-

ological variability, 208Gershanik, 0., see Rubinstein, M., 810Gharib, C., see Damase-Michel, C., 770Gilchrest, H., see Billah, M. M., 1090Gill, K. K. and Kroeger, E. A.: Effects of

indomethacin on neural and my-

ogenic components in equine airway

smooth muscle, 358Gillis, R. A., see Jam, R. K., 147Giuliani, S., Lippe, I. Th., Maggi, C. A. and

Meli, A.: Dual effects of cholecysto-kinin-octapeptide on duodenal motil-ity ofurethane-anestheized rats, 1312

Glibenclamide, renal hemodynamics andfunction, cromakalim effects (dogs),1240

N-Glucuronides, norgallopamil and norver-apamil, 593

Glutamate-induced neuronal death, cerebellar gran-

ule cells (rats), 419NDMA receptor system, evoked GABA

release, striatal neurons (mice), 380

Glutathione

bronchiolar Clara cell necrosis, naphtha-

lene, lung (mice), 428

1990 Index 1393

inhibition ofacid formation, AG-1749, pa-

rietal cells (dogs), 1289Glycine, antagonists, NMDA-induced con-

vulsions, NMDA antagonists (mice),

349Goldberg, S. R., see Schindler, C. W., 8Goldberg, S. R., see Tella, S. R., 491Golfarb, J., see Christ, G. J., 500Gonzalez, F. J., see Relling, M. V., 442Goon, D. and Klaassen, C. D.: Dose-depend-

ent intestinal glucuronidation andsulfation of acetaminophen in the rat

in Situ, 201Goossens, J., see van Wauwe, J. P., 365Goyal, R. K., see Saha, J. K., 1012G-protein

-linked serotonin receptors in kidney, 5-HT1b receptors in brain (mice), 1347

pertussis toxin effect, interaction, azepex-ole and halothane (guinea pigs), 1156

Greenwald, J., see Cicero, T. J., 456Griffith, W. H., see Frye, G. D., 474Griffiths, R. R., Evans, S. M., Heishman, S.

J., Preston, K. L., Sannerud, C. A.,Wolf, B. and Woodson, P. P.: Low-dose caffeine discrimination in hu-

mans, 970Grous, M., see Barnette, M. S., 1160Gruber, S. A., Cipolle, R. J., Tzardis, P.,

Skjei, K., Jossart, G., Abed, J. F.,Canafax, D. M., Burke, B. A., Mates,

A. J. and Hrushesky, W. J. M.: Phar-macodynamics of local heparin infu-sion in a canine renal allograft model,733

Guarino, J. J., see Boisse, N. R., 1125Guidotti, A., see Manev, H., 419Gulati, A., see Bhargava, H. N., 901Gusovsky, F., Bitran, J. A., Yasumoto, T.

and Daly, J. W.: Mechanism of mai-totoxin-stimulated phosphoinositide

breakdown in HL-60 cells, 466Gust, S. W., see Hughes, J. R., 1175

H-7, effect on stress, crossbridge phosphor-ylation, inositol phosphate produc-

tion in arteries (rabbits), 253Haloperidol, SCH 23390 and, dopaminergic

and serotonergic mechanisms, brain(rats), 845

Halothane, azepexole and, pertussis toxineffect (guinea pigs), 1156

Halter, F., see Scheurer, U., 1324Hamosh, P., see Jam, R. K., 147Harada, Y., see Yamada, S., 327Harbon, S., see Leiber, D., 800Harder, D. R., see Kauser, K., 93Hartz, R. S., see Rasmussen, H. H., 60Hayashi, K., Matsumura, Y., Yoshida, Y.,

Ohyama, T., Hisaki, K., Suzuki, Y.and Morimoto, S.: Effects of BRL34915 (cromakalim) on renal hemo-

dynamics and function in anesthe-

tized dogs, 1240Hayes, B. A., see Beardsley, P. M., 953Heart

atrial tissue, electrogenic Na�-pumping

inhibition, digoxin (humans), 60

cocaine-mediated impairment (dogs), 185

potentiation of cardiac effects, cocaine,neurally released norepinephrine

(cats), 147prazosin-sensitive component, inotropic

response to norepinephrine (rabbits),853

rate perfusion pressure, substance P(guinea pigs), 179

role of membrane lipid order, tetrahydro-cannabinol, adenylate cyclase acti-vation (rats), 1075

Heat, noxious, differential release, sub-stance P and somatostatin (rats), 539

Heishman, S. J., see Griffiths, R. R., 970Hemodynamics

evaluation of endothelin-1 (rats), 300renin inhibition induced by A-64662, ex-

cretory responses (monkeys), 449Henningsen, R. A., see Nerve, K. A., 1108Heparin, local infusion, pharmacodynamics,

renal allograft model (dogs), 733Hepatocytes, altered hepatobiliary disposi-

tion, acetaminophen metabolites,phenobarbital pretreatment (rats),657

Hepatotoxicity

acetaminophen, methylxanthines, induc-

tion states (rats), 11202-dependent, ethylhexanol, mitochon-

dna (rats), 1355

Hepner, A., see Hrdina, P. D., 410Herczeg, T., see Yu, K. T., 192Herman, J. R. and Bass, P.: Pharmacologic

characterization of the changes in

cholinergic sensitivity of rat jejunalcircular muscle after myentericplexus ablation, 135

Hernandez, J. S., Van Loon, J. A., Otter-ness, D. M. and Weinshilboum, R.

M.: Mouse thiopurine methyltrans-ferase pharmacogenetics: Correlationof immunoreactive protein and en-

zymatic activity, 568

Herzer, W. A., see Deray, G., 631Heyman, J. S., see Jiang, Q., 1006Hieble, J. P., see Willette, R. N., 706Hietala, J., see Lappalainen, J., 845Hillard, C. J., Pounds, J. J., Boyer, D. R.

and Bloom, A. S.: Studies of the roleof membrane lipid order in the effects

of $�-tetrahydrocannabinol on eden-ylate cyclase activation in heart, 1075

HippocampusCA3 pyramidal cells, mu opioid receptor

activation, inhibitory postsynapticpotentials (rats, guinea pigs), 1361

CGS 21680 effects on electrophysiology,cAMP formation, dopamine release(rats), 1134

ethanol tolerance in neurons (rats), 265glycine-evoked neurotransmitter release

(rats), 574Hisaki, K., see Hayashi, K., 1240Histamine

block of increase in intracellular calcium,doxorubicin, neuroblastoma cells,

979dual antagonist, SCH 37370 (guinea pigs),

1090tachykinin-induced anion secretion, dis-

tal colon (guinea pigs), 1HL-60 cells, maitotoxin-stimulated phos-

phoinositide breakdown, mechanism,466

Ho, I. K., see Burton, C. K., 104Hoffman, B. B., see Thomas, J. M., 616Hoffman, G. W., Jr., see Kabas, J. S., 185Hohlfeld, J., Liebau, S. and F#{246}rstermann,

U.: Pertussis toxin inhibits contrac-tions but not endothelium-dependentrelaxations of rabbit pulmonary ar-

tery in response to acetylochline andother agonists, 260

Hoke, G. D., Cheng, H.-Y., Mirabelli, C. K.and Rush, G. F.: Mechanism of inhi-bition of rat liver mitochondrial res-

piration by oxmetidine, an H2-recep-tor antagonist, 908

Hollenberg, M. D., see Gan, B. S., 1277Holtman, J. R., Jr., see King, K. A., 665Hong, J.-S., see Paul, I. A., 997Hoover, D. B.: Effects of substance P on

rate and perfusion pressure in theisolated guinea pig heart, 179

Hori, R., see Tomita, Y., 859Horiuchi, A., Iwatsuki, K., Yonekura, H.,

Ran, L-M. and Chiba, S.: Gabexateand camostat, synthetic proteinaseinhibitors, as direct inducing factorsof water and bicarbonate secretion inthe isolated and blood-perfused dogpancreas, 320

Horn, R., see Fiorica-Howells, E., 610Hoskins, B., see Burton, C. K., 104Hoyer, D., see Schoeffter, P., 387Hrdina, P. D., Foy, B., Hepner, A. and Sum-

mers, R. J.: Antidepressant bindingsites in brain: Autoradiographic com-parison of [3Hjparoxetine and 13H1imipramine localization and relation-ship to serotonin transporter, 410

Hruby, V. J., see Spencer, R. L., 696Hrushesky, W. J. M., see Gruber, S. A., 733Hsu, C.-Y., see Tune, B. M., 65Hughes, H., see Shappell, S. B., 531Hughes, J. R., Gust, S. W., Keenan, R. M.

and Fenwick, J. W.: Effect of dose onnicotine’s reinforcing, withdrawal-

suppression and self-reported effects,1175

Hulihan-Giblin, B. A., Lumpkin, M. D. andKeller, K. J.: Effects of chronic ad-ministration of nicotine on prolactinrelease in the rat: Inactivation of pro-lactin response by repeated injectionsof nicotine, 21

Hulihan-Giblin, B. A., Lumpkin, M D. and

Kellar, K. J.: Acute effects of nicotineon prolactin release in the rat: Ago-nist and antagonist effects of a singleinjection of nicotine, 15

Hunter, J. B., see Scheufler, E., 333Huxtable, R. J., see Shubat, P. J., 705-Hydroxytryptamine2, receptor character-

ization, medial prefrontal cortex

(rats), 1715-Hydroxytryptamine, see also Serotonin

-induced endothelium-dependent relaxa-tion, coronary arteries (pigs), 387

receptors, see ReceptorsHyman, A., see Le Monnier de Gouville, A.

C., 300Hypertension

antihypertensive effects of CGS 19281A(rats), 117

genetic, phorbol-12,13-dibutyrate, vaso-

constriction (rats), 526nonpeptide angiotensin H receptor antag-

onists, DuP 753 (rats), 711, 719, 726

Ichinose, M. and Barnes, P. J.: A potassiumchannel activator modulates both ex-citatory noncholinergic and cholin-ergic neurotransmission in guinea pig

airways, 1207IC! 204,219, contractile responses to pepti-

1394 Index Vol. 252

doleukotrienes, epithelium (guinea

pigs), 77Ileum

atypical beta adrenoceptors, antagonistcharacterization (guinea pigs), 1034

comparison of contractile responses,ethanol and GABAA agonists, longi-tudinal muscle (guinea pigs), 474

contractile response te bombesin, longi-

tudinal muscle (guinea pigs), 339

pertussis toxin effect, interaction, azepex-ole and halothane (guinea pigs), 1156

pharmacological characterization, neu-ronal receptor, serotonin (guineapigs), 1378

Imidazoline, -guanidinium receptive site,renal proximal tubule (rabbits), 293

Imipramineantidepressant binding sites in brain

(rats), 410neural adaptation, forced swim test (rats),

997Indole, antagonism of -y-aminobutyric acidA

receptor, amino--y-carbolines (mice),1269

Indolealkylamines, melatonin analogs,

quantitative structure-activity rela-tionships, 370

Indomethacin, effects on neural and my-ogenic components, airway smoothmuscle (horses), 358

Inoki, R., see Ohkubo, T., 1261Inositol phosphate

agonist-induced muscarinic receptor loss,phosphoinositide turnover, neuro-blastoma (humans), 744

desimipramine and lithium, serotonergicreceptor number, second messengerfunction in brain (rats), 826

increased generation, muscarinic receptorsubtypes, myometrium (guinea pigs),800

production in arteries, effect of H-7,crossbridge phosphorylation (rab-bits), 253

Inositol polyphosphates, formation in air-way smooth muscle, muscarinic re-ceptor stimulation, 786

Intestinebrush-border membrane, transport mech-

anisms, bestatin (rabbits), 859duodenal motility, cholecystokinin-octa-

peptide, urethane (rats), 1312glucuronidation and sulfation, acetami-

nophen (rats), 201Inui, K.-!., see Tomita, Y., 859Ion channel

acetylcholine receptor, activation and

blockade, anatoxin-a (frogs), 517molecular effects of dimethylanatoxin,

peripheral nicotinic acetylcholine re-ceptor, 507

Ionic current, cromakalim actions, singlesmooth muscle cells, portal vein(rats), 832

Ionsneurohormonal regulation of transport,

distal jejunum (pigs), 126transport in jejunum, nerve stimulation,

Veratrum alkaloids (mice), 636Iorio, L. C., see Breese, G. R., 558Ischemia, myocardial, cardioprotective ef-

fects, sodium nitrite (cats), 35Isobologram, drug interactions, biological

variability (mice), 208

Isoproterenol, chronic administration, al-

tered beta adrenoceptor-G,-coupling,lung (guinea pigs), 1341

Iwatsuki, K., see Horiuchi, A., 320

Jackson, E. K., see Deray, G., 631Jacobson, A. E., see France, C. P., 600Jagadeesh, G., Cragoe, E. J., Jr. and Deth,

R. C.: Modulation of bovine aorticalpha-2 receptors by Na�,Gpp(NH)p, amiloride and ethyliso-propylamiloride: Evidence for recep-tor/G-protein precoupling, 1184

Jam, M. K., see Jam, R. K., 147Jam, R. K., Jam, M. K., Bachenheimer, L.

C., Visner, M. S., Hamosh, P., Tracy,C. M. and Gillis, R. A.: Factors deter-mining whether cocaine will poten-tiate the cardiac effects of neurallyreleased norepinephrine, 147

Jan, C.-R., see Bigornia, L., 586Janowsky, A., see Nerve, K. A., 1108Jejunum

circular muscle, cholinergic sensitivity,

myenteric plexus ablation (rats), 135distal, neurohormonal regulation, ion

transport (pigs), 126ion transport, nerve stimulation, Vera-

trum alkaloids (mice), 636

Jiang, L. H., see Ashby, C. R., Jr., 171Jiang, Q., Heyman, J. S., Sheldon, R. J.,

Koslo, R. J. and Porreca, F.: Mu an-tagonist and kappa agonist propertiesof fl-funaltrexamine in Long lasting

spine.! ana�gesla in mice, 1006Johns, R. A., see Tracey, W. R., 922Johnson, A. L., see Chiu, A. T., 711Johnson, A. L., see Wong, P. C., 719, 726Johnson, G., III, Tsao, P. S., Mulloy, D. and

Lefer, A. M.: Cardioprotective effects

of acidified sodium nitrite in myocar-

dial ischemia with reperfusion, 35Johnson, R. E., see Vaupel, D. B., 225Jones, J. A., see Brouwer, K. L. R., 657Jones, J. A., see Plevin, R., 1296Jossart, G., see Gruber, S. A., 733

Kabas, J. S., Blanchard, S. M., Matsuyama,Y., Long, J. D., Hoffman, G. W., Jr.,Ellinwood, E. H., Smith, P. K. andStrauss, H. C.: Cocaine-mediated im-pairment of cardiac conduction in thedog A potential mechanism for sud-

den death after cocaine, 185Kadam, J. R. C., see Verburg, K. M., 449Kado-Fong, H., see Malfroy, B., 462Kainate, phencyclidine-like behavioral ef-

fects, NMDA-induced convulsions,NMDA and glycine antagonists(mice), 349

Kajioka, S., see Okabe, K., 832Kalhorn, T. F., Lee, C. A., Slattery, J. T.

and Nelson, S. D.: Effect of meth-ylxanthines on acetaminophen he-patoxicity in various inductionstates, 112

Kalivas, P. W., see Austin, M. C., 1370Kanai, Y., Wada, 0. and Manabe, S.: An-

tagonism of -y-aminobutyric acidA re-ceptor-mediated responses by amino-y-carbolines, 1269

Kanekal, S., Plopper, C., Morin, D. andBuckpitt, A.: Metabolic activationand bronchiolar clara cell necrosis

from naphtahalene in the isolatedperfused mouse lung, 428

Kaneko, T., see Nakazawa, T, 1247Kanno, S., see Takahashi, H., 272Kaplan,D.S.,seeNandi,J., 1102Karakiulakis, G., see Maragoudakis, M. E.,

753Karlssson, J.-A., Lanner, A.-S. and Persson,

C. G. A.: Airway opioid receptors me-diate inhibition of cough and reflexbronchoconstriction in guinea pigs,863

Karobath, M., see Coward, D. M, 279Kasiewski, C. J., see Bilder, G. E., 526Kasser, R. J., see Ashby, C. R., Jr., 171Katsura, T., see Tomita Y., 859Katz, J. L., see Schindler, C. W., 8Kau, D., see Lindatrom T. D., 1117Kauffman, F. C., see Keller, B. J., 1355Kauser, K., Rubanyi, G. M. and Harder, D.

R.: Endothelium-dependent modula-tion of endothelin-induced vasocon-striction and membrane depolarize-tion in cat cerebral arteries, 93

Kawai, Y. and Ohhashi, T.: Age-relatedchanges in relaxant response of vas-cular smooth muscles to atrial natri-uretic peptide, 1234

Kawasaki, H., Nuki, C., Saito, A. and Tak-asaki, K.: Role of calcitonin gene-related peptide-containing nerves in

the vascular adrenergic neurotrans-mission, 403

Kazanietz, M. G. and Enero, M. A.: Desen-sitization ofthe Beta-2 adrenoceptor-mediated vasodilation in rat aorta

after prolonged treatment with theBeta-2 adrenoceptor agonist clenbu-terol, 758

Keenan, R. M., see Hughes, J. R., 1175Keith, R. A., see Mangano, T. J., 574Kellar, K. J., see Hulihan-Giblin, B. A., 15,

21

Keller, B. J., Yamanaka, H., Liang, D.,Kauffman, F. C. and Thurman, R.G.: Oxygen-dependent hepatotoxicitydue to ethylhexanol in the perfusedrat liver: Mitochondria as a site ofaction, 1355

Kelly, T. H., Foltin, R. W., Rose, A. J.,Fischman, M. W. and Brady, J. V.:

Smoked marijuana effects on tobaccocigarette smoking behavior, 934

Kessler, R. M., see Nerve, K. A., 1108Khanna, J. M., see Reynolds, J. N., 265Kidney

acute renal failure, peptidases, brush-bor-der membrane vesicles (rats), 98

disposition of choline, dimethylaminoe-

thanol (rats), 154epithelial cells

organic cation transport, 286oxytocin stimulation, phosphoinositide

hydrolysis, 552

G-protein-linked serotonin receptors, 5-HTIb receptors in brain (mice), 1347

hemodynamics and function, cromakalimeffects (dogs), 1240

mitochondrial toxicity, cephalosporins(rabbits), 65

modulation of renal response to endothe-lin, cycbooxygenase products, atrialnatriuretic peptide (rats), 1213

phenobarbital pretreatment, altered hep-

1990 Index 1395

atobiliary disposition, acetamino-phen metabolites (rats), 657

proximal tubular transport, mechanism,angiotensin II action (rats), 689

proximal tubule, imidazoline-guanidi-nium receptive site (rabbits), 293

renal allograft model, pharmacody-namics, local heparin infusion (dogs),733

renal selective N-acetyl--y-glutamyl pro-drug, 1255

renin inhibition by A-64662, hemody-namic and excretory responses (mon-keys), 449

tachyphylaxis to vasoconstrictor effect,arachidonic acid (rats), 241

urate and p-aminohippurate transport,brush border membrane (pigs), 792

Killam, A. L., Nikam, S. S., Lambert, G. M.,Martin, A. R. and Nelson, D. L.:Comparison of two different arterialtissues suggests possible 5-hydroxytryptamine2 receptor hetero-geneity, 1083

Kimura, R., see Yamada, S., 327King, K. A. and Holtman, J. R., Jr.: Char-

acterization of the effects of activa-tion of ventral medullary serotoninreceptor subtypes of cardiovascularactivity and respiratory motor out-flow to the diaphragm and larynx,665

King, R. L., see Nandi, J., 1102Kinins, cyclic GMP production, bradykinin,

aortic endothelial cells (porcine), 581Kinzie, J. M., see Nerve, K. A., 1108Kirchner, K. A., Voelker, J. R. and Brater,

D. C.: Intratubular albumin bluntsthe response to furosemide-A mech-anism for dieuretic resistance in thenephrotic syndrome, 1097

Kitamura, K., see Okabe, K., 832Klaassen, C. D., see Goon, D., 201Kleinert, H. D., see Verburg, K. M., 449Kook, W. and Colpaert, F. C.: Selective

blockade of N-methyl-D-aspartate(NMDA)-induced convulsions byNMDA antagonists and putative gly-cine antagonists: Relationship withphencyclidine-like behavioral effects,349

Kofuji, P., Aracava, Y., Swanson, K. L.,Aronstam, R. S., Rapoport, H. andAlbuquerque, E. X.: Activation andblockade of the acetylcholine recep-tor-ion channel by the agonists (+)-anatoxin-a, the N-methyl derivativeand the enantiomer, 517

Komori, K., Flavahan, N. A., Miller, V. M.and Vanhoutte, P. M.: Electrophysi-ological analysis of adrenergic neu-rotransmission and its modulation bychronic denervation in canine sa-phenous veins, 1197

Koslo, R. J., see Jiang, Q., 1006Koulu, M., see Lappalainen, J., 845Krell, R. D., see Buckner, C. K., 77Kreutner, W., see Billah, M. M., 1090Kroeger, E. A., see Gill, K. K., 358Kudlacz, E. M., Navarro, H. A., Eylers, J.

P. and Slotkin, T. A.: Prenatal ex-posure to propranolol via continuousmaternal infusion: Effects on phys-iological and biochemical processes

mediated by Beta adrenergic recep-

tom in fetal and neonatal rat lung, 42Kuhn, C., see Paul, I. A., 997Kuo, J. S., see Yang, M. C. M., 840Kuriyama, H., see Okabe, K., 832Kuwahara, A. and Cooke, H. J.: Tachykinin-

induced anion secretion in guinea pigdistal colon: Role of neural and in-flammatory mediators, 1

Lafontan, M., see Galitzky, J., 312Lambert, G. M., see Killam, A. L., 1083Lanner, A.-S., see Karlsson, J.-A., 863Lappalainen, J., Hietala, J., Koulu, M., Sep-

p#{228}i#{228},T., Sj#{246}holm,B. and Syv#{228}lahti,E.: Chronic treatment with SCH23390 and haloperidol: Effects on do-paminergic and serotonergic mecha-nisms in rat brain, 845

Larrouy, D., see Galitzky, J., 312Larynx, activation of ventral medullary se-

rotonin receptor subtypes, cardiovas-cular activity (cats), 665

Lee,C.A.,seeKalhorn,T.F., 112Lee, W., Nicklaus, K. L., Manning, D. R.

and Wolfe, B. B.: Ontogeny of corti-cal muscarinic receptor subtypes andmuscarinic receptor-mediated re-sponses in rat, 482

Lees, J. G., see Adeagbo, A. S. 0., 875Lefer, A. M., see Johnson, G., III, 35Legato, M. J., see Viamonte, V. M., 886Leiber, D., Marc, S. and Harbon, S.: Phar-

macological evidence for distinctmuscarinic receptor subtypes coupledto the inhibition of adenylate cyclaseand to the increased generation ofinositol phosphates in the guinea pigmyometrium, 800

Le Monnier de Gouville, A. C., Mondot, S.,Lippton, H., Hyman, A. and Cavero,I.: Hemodynamic and pharmacologi-cal evaluation of the vasodilator andvasoconstrictor effects of endothelin-1 in rats, 300

Lerer, B., see Newman, M. E., 826Leukotriene B4, lipoxygenase inhibitors,

neutrophil function (humans), 531Leukotrienes, indomethacin effects on

neural and myogenic components,airway smooth muscle (horses), 358

Levine, R. A., see Nandi, J., 1102Lewis, D. F. V., Arendt, J. and English, J.:

Quantitative structure-activity rela-tionships within a series of melatoninanalogs and related mdolealkylam-ines, 370

Lewis, E. J., see Bloxham, D. P., 1331Liang, D., see Keller, B. J., 1355Lidocaine, catamphiphilic drug uptake, cal-

cium displacement, erythrocytes andmuscular tissue (humans), 333

Liebach, F. H., see Miyamoto, Y., 98Liebau, S., see Hohlfeld, J., 260Liggitt, D., see Maifroy, B., 462Linden, J., see Tracey, W. R., 922Lindstrom, T. D., Althaus, W. A., Ruterbor-

ies, K. J. and Kau, D.: Phamacoki-netics and disposition of the KS1/4monoclonal antibody-desacetylvin-blastine hydrazide conjugateLY203725 in rats and monkeys, 1117

Lipids, membrane order, tetrahydrocanna-binol, adenylate cyclase activation inheart (rats), 1075

Lipolysis, characterization of aipha-2 Aadrenoceptors, fat cells (humans),312

Lipoxygenase, inhibitors, neutrophil func-tion (humans), 531

Lippe, I. Th., see Giuliani, S., 1312Lippton, H., see Le Monnier de Gouville, A.

C., 300Lisinopril, biliary excretion and conjugation

(rats), 1202Lithium

desimipramine and, serotonergic receptornumber, second messenger functionin brain (rats), 826

renal hemodynamics and function, cro-makalim effects (dogs), 1240

Liu-Chen, L.-Y., see Tiseo, P. J., 539Liver

altered hepatobiliary disposition, aceta-minophen metabolites, phenobarbi-tal pretreatment (rats), 657

biliary excretion and conjugation, diacidangiotensin-converting enzyme in-hibitors (rats), 1202

intestinal glucuronidation and sulfation,acetaminophen (rats), 201

mitochondrial respiration, inhibition byoxmetidine (rats), 908

02-dependent hepatotoxicity, ethyihex-anol, mitochondria (rats), 1355

Liver microsomes, covalent binding of phen-ytoin to protein, metabolism modu-lation, thiols (mice), 895

Locomotion, NMDA-induced convulsions,NMDA and glycine antagonists(mice), 349

Lohr, J. and Acara, M.: Effect of dimethy-laminoethanol, an inhibitor of be-tame production, on the dispositionof choline in the rat kidney, 154

Long, J. D., see Kabas, J. S., 185Lorenzetti, M., see Frye, G. D., 474Lumpkin, M. D., see Hulihan-Giblin, B. A.,

15, 21Lung

bronchiolar Clara cell necrosis, naphtha-lene (mice), 428

chronic isoproterenol administration,beta adrenoceptor-G1-coupling(guinea pigs), 1341

fetal and neonatal, prenatal exposure,propanolol (rats), 42

peripheral type benzodiazepine receptors(guinea pigs), 880

smooth muscle, endothelin-induced con-tractions, pinacidil antagonism(guinea pigs, rats), 1318

Lupica, C. R., Cass, W. A., Zahniser, N. Rand Dunwiddie, T. V.: Effects of theselective adenosine A2 receptor ago-nist CGS 21680 on in vitro electro-physiology, cyclic AMP formationand dopamine release in the rat hip-pocampus and striatum, 4, 113

LY203725, KS1/4 monoclonal antibody-de-sacetyl-vinbiastine hydrazide conju-gate, pharmacokinetics, disposition(rats, monkeys), 1117

Lyon, R. A., see Bigornia, L., 586

Maayani, S., see Christ, G. J., 500Mac-i, lipoxygenase inhibitors, neutrophil

function (humans), 531Macrophages, zymosan-stimulated PAF

1396 Index Vol. 252

production, inhibition by ethanol,1028

Maggi,C.A.,seeGiuliani,S., 1312Magnesium, depression of segmental poly-

synaptic reflex, phencyclidine (rats),246

Maitotoxin, -stimulated phosphoinositidebreakdown, mechanism, HL-60 cells,466

Mak, J. C. W. and Barnes P. J.: Peripheraltype benzoidazepine receptors in hu-man and guinea pig lung: Character-ization and autoradiographic map-ping, 880

Maki, Y., see Nagaya, H., 1289Malarchik, M. E., see Sheldon, R. J., 636Malfroy, B., Liggitt, D., McCabe, J., Baugh-

man, R., Kado-Fong, H., Mulholland,K., Bridenbaugh, R. and Anderson,J.: Administration of recombinantenkephalinase (neutral endopepti-dase) prevents capsaicm-inducedmiosis in the rabbit eye in Vivo, 462

Malik, K. U., see Adeagbo, A. S. 0., 26Manabe, S., see Kanai, Y., 1269Manev, H., Favaron, M., Vicini, S., Gui-

dotti, A. and Costa, E.: Glutamate-induced neuronal death in primarycultures of cerebellar granule cells:protection by synthetic derivatives ofendogenous sphingolipids, 419

Mangano, T. J., Patel, J., Salama, A. I. andKeith, R. A.: Glycine-evoked neuro-transmitter release from rat hippo-campal brain slices: Evidence for theinvolvement of glut.aminergic trans-mission, 574

Manniello, M. J., see Chatelain, R. E., 117Manning, D. R., see Lee, W., 482Maragoudakis, M. E., Missirlis, E., Sarmon-

ika, M., Panoutsacopoulou, M. andKarakiulakis, G.: Basement mem-brane biosynthesis as a target to tu-mor therapy, 753

Marc, S., see Leiber, D., 800Marijuana

effects on tobacco cigarette smoking be-havior (humans), 934

role of membrane lipid order, adenylatecyclase activation, heart (rats), 1075

Marriott, D. B., see Plevin, R., 1296Martin, A. R., see Killam, A. L., 1083Martin, B. R., see Gennings, C., 208Martin, T. J., see Gennings, C., 208Martinez, F., see Werner, D., 792Matas, A. J., see Gruber, S. A., 733Matsuda, T., see Fujimoto, S., 1304Matsumura, Y., see Hayashi, K., 1240Matsuyama, Y., see Kabas, J. S., 185McAllen, K. M., see Gainey Matta, 5., 623McCabe, J., see Maifroy, B., 462McCall, D. E., see Chiu, A. T., 711McDonagh, A. F., see Smith, P. C., 218McDonough, K. H., see Barker, L. A., 675McGiff, J. C., see Quilley, J., 241McQuade, R. D., see Breese, G. R., 558Mecamylamine, isobolographic character-

ization, drug interactions, biologicalvariability (mice), 208

Mecanylamine, role of fourth cerebroventri-cle, plasma ACTH responses, nic-otine (rats), 623

Meisheri, K. D., Sage, G. P.,!! and Cipkus-Dubray, L. A.: Factors affecting rab-bit mesenteric artery smooth muscle

sensitivity to calcium antagonists,

1167

Melatonin, analogs and related indolealky-

lamines, quantitative structure-ac-tivity relationships, 370

Meli, A., see Giuliani, S., 1312Membrane, lipid order, tetrahydrocannabi-

nol, adenylate cyclase activation inheart (rats), 1075

Mephenytoin, hydroxylation, tolbutamide,cytochrome P450s (humans), 442

Methadone, differential cross-tolerance,shock titration schedule (monkeys),845

N-Methyl-D-aspartatedepression of segmental polysynaptic re-

flex, phencyclidine (rats), 246-induced convulsions, NMDA antago-

nists, glycine antagonists (mice), 349

Methylxanthines, acetaminophen hepato-toxicity, different induction states(rats), 112

Metoprolol, electrophysiological effects,ventricular myocytes (cats), 1043

Meyer, U. A., see RaIling, M. V., 442Michel, A. D., see Blue, D. R., 1034Midazolam, tolerance and physical depend-

ence (rats), 1125Miller, V. M., see Komori, K., 1197Mine, K., see Okada, M., 1283Miosis, capsaicin-induced, prevention, re-

combinant enkephalinase (rabbits),

462

Mirabelli, C. K., see Hoke, G. D., 908Missirlis, E., see Maragoudakis, M. E., 753Mitchell, J. R., see Shappell, S. B., 531Mitochondria

02-dependent hepatotoxicity, ethylhex-anol (rats), 1355

renal toxicity of cephalosporins (rabbits),65

respiration inhibition by oxmetidine, liver

(rats), 908Miyamoto, Y., Ganapathy, V. and Leibach,

F. H.: Peptidases and peptide trans-

port in renal brush-border membranevesicles from rats with acute renal

failure, 98

MK-801glycine-evoked neurotransmitter release,

hippocampus (rats), 574self-administration, drug-reinforcement

history, discriminative stimulusproperties (monkeys), 953

Mok, L. L. S., see Reynolds, E. E., 915

Monbaliu, J., see van Wauwe, J. P., 365Mondot, S., see Le Monnier de Gouville, A.

C., 300Monoclonal antibodies, desacetyl-vinblas-

tine hydrazine conjugate LY203725,pharmacokinetics, disposition (rats,monkeys), 1117

Monocrotaline, Na�/K�-adenosine triphos-phatase activity, pulmonary arteries(rats), 70

Montastruc, J.-L., see Damase-Michel, C.,770

Morimoto, S., see Hayashi, K., 1240Morin, D., see Plopper, C., 428Moron, M. A., Stevens, C. W. and Yaksh,

T. L.: Antiseizure activity of dihydro-pyridine calcium channel antagonistsin the conscious rat, 1150

Morphineaffinity of opioid antagonists, saline and

naltrexone discrimination (mon-keys), 600

blockade of voltage-dependent potassiumcurrents, phencyclidine, thymocytes

(mice), 610differential cross-tolerance, shock titra-

tion schedule (monkeys), 845

-induced inhibition, tail-flick response,mechanisms (rats), 546

lethality, Toxoplasma gondii infection(mice), 605

salmon calcitonin and, parathyroid hor-

mone peptide fragments (mice), 140tolerance, cyclic GMP phosphodiesterase

(rats), 104

withdrawal, dopamine D1 receptors, brainand spinal cord (rats), 901

Mucosa, gastric alkaline secretion, influence

of stress (rats), 1228

Mueller, R. A., see Breese, G. R., 558Mueller, R. A., see Paul, I. A., 997Mulholland, K., see Malfroy, B., 462Mulloy, D., see Johnson, G., I!!, 35

Muntz, K. H., see Shaul, P. W., 86Muschietti, J. P., see Rubinstein, M., 810

Musclelongitudinal

contractile responses, ethanol and GA-

BAA agonists (guinea pigs), 474

contractile response to bombesin, ileum

(guinea pigs), 339nonpeptide angiotensin II receptor antag-

onists, DuP 753 (rats), 711, 719, 726

uptake of catamphiphilic drugs, calciumdisplacement, phosphatidylserine

monolayers (humans), 333Muscle, smooth

airway

indomethacin effects, neural and my-

ogenic components (horses), 358

inositol polyphosphate formation, mus-

carinic receptor stimulation, 786carotid medial, phorbol ester-induced

stress, myosin light chain phosphor-

ylation (swine), 1068coronary artery, endothelium effects,

basal tone and agonist (pigs), 1053endothelin-induced contractions, pinaci-

dil antagonism (guinea pigs, rats),1318

esophageal longitudinal, bradykinin effect(opossums), 1012

inositol phosphate production, effect ofH-7, crossbrdige phosphorylation(rabbits), 253

lower esophageal sphincter relaxation,cAMP-dependent protein kinase

(dogs), 1160mesenteric artery, sensitivity, calcium an-

tagonists (rabbits), 1167

vascular, age-related changes in relaxant

response, atrial natriuretic peptide

(rats), 1234Mutlib, A. E. and Nelson, W. L.: Synthesis

and identification of the N-glucuro-nides of norgallopamil and norvera-

pamil, unusual metabolites of gallo-pamil and verapamil, 593

Myeloperoxidase, cardioprotective effects of

sodium nitrite, myocardial ischemia,reperfusion (cats), 35

Myenteric plexus, ablation, cholinergic sen-

sitivity, jejunal circular muscle (rats),

135

1990 Index 1397

Nervescalcitonin gene-related peptide-contain-

Myocardium, neutrophil function, lipoxy-genase inhibitors (humans), 531

Myocytes

modulation of automaticity, phospholi-pase C, cardiac Purkinje fibers (dogs),886

ventricular, electrophysiological effects,

metoprolol (cats), 1043

Myometrium, muscarinic receptor subtypes,

inositol phosphate generation, aden-

ylate cyclase inhibition (guinea pigs),800

Myosininositol phosphate production, effect of

H-7, crossbridge phosphorylation

(rabbits), 253

light chain phosphorylation, phorbol es-

tar-induced stress, carotid medial

smooth muscle (swine), 1068

Nagaya, H., Satoh, H. and Maki, Y.: Possi-ble mechanism for the inhibition of

acid formation by the proton pumpinhibitor AG-1749 in isolated canine

parietal cells, 1289Nahorski, S. R., see Chilvers, E. R., 786Nakao, K., see Okabe, K., 832Nakayama, K., see Yamada, S., 327, 765Nakazawa, T., Furuya, Y., Kaneko, T., Ya-

matsu, K., Yoshino, H. and Tachi-

bans, S.: Analgesia produced by E-2078, a systemically active dynorphin

analog, in mice, 1247

Naloxone

analgesia produced by E-2078 (mice),1247

blockade of voltage-dependent potassiumcurrents, phencyclidine, thymocytes

(mice), 610

Naltrexone

saline discrimination, opioid antagonists,

morphine (monkeys), 600

sensitivity to behavioral effects (rats), 8

Nandi, J., King, R. L., Kaplan, D. S. andLevine, R. A.: Mechanisms of gastric

proton pump inhibition by calciumchannel antagonists, 1102

Naphthalene, bronchiolar Clara cell necro-sis, metabolic activation, lung (mice),428

Narahashi, T., see Ogata, N., 1142

Natriuresis, modulation of renal response to

endothelin, cycbooxygenase products,

atrial natriuretic peptide (rats), 1213

Navarro, H. A., see Kudlacz, E. M., 42Nelson, D. L., see Killam, A. L., 1083

Nelson, S. D., see Kalhorn, T. F, 112Nelson, W. L., see Mutlib, A. E., 593

Neocortex, inhibition of norepinephrine andacetylcholine release, w-conotoxinGVIA (humans), 778

Neostigmine, rate perfusion pressure, sub-

stance P (guinea pigs), 179Nephrotic syndrome, response to furose-

mide-A mechanism, intratubular al-

bumin (rats), 1097

Nephrotoxicity, renal mitochondria, cepha-losporins (rabbits), 65

Nerme, V., Abrahamsson, T. and Vauquelin,

G.: Chronic isoproterenol adminis-tration causes altered beta adreno-ceptor-G.-coupling in guinea piglung, 1341

ing, vascular adrenergic neurotrans-

mission (rats), 403

drug-induced release of adenine nucleo-

sides, nucleotides, aorta (rabbits),

1060indomethacin effects on neural and my-

ogenic components, airway smoothmuscle (horses), 358

stimulation, ion transport, jejunum

(mice), 636Neuroblastoma

agonist-induced muscarinic receptor loss,

phosphoinositide turnover (humans),

744

blockade of increase in intracellular cal-cium, doxorubicin, 979

potent blocking action of chlorpromazine,

calcium channels (mice), 1142

Neurokinin A, tachykinin-induced anion se-

cretion, distal colon (guinea pigs), 1

Neurons

hippocampal, ethanol tolerance (rats),

265

mesoprefrontal dopamine, modulation,

central benzodiazepine receptors, 989

striatal, NMDA receptor system, evoked

GABA release (mice), 380Neurotensin, -induced dopamine release,

substantia nigra, nucleus caudate

(rabbits), 817

Neurotoxicity, glutamate, cerebellar granule

cells (rats), 419

Neurotoxins, cellular localization of sero-

tonin 1A,1B, uptake sites, cingulate

cortex (rats), 651Neurotransmission

adrenergic, electrophysiology, saphenousveins (dogs), 1197

enkephalinergic and GABAergic modula-

tion, motor activity, ventral pallidum

(rats), 1370

excitatory noncholinergic and cholinergic,potassium channel activator, airways(guinea pigs), 1207

vascular adrenergic, calcitonin gene-re-lated peptide-containing nerves

(rats), 403

Neurotransmitter, glycine-evoked release,hippocampus (rats), 574

Neutrophils, function, lipoxygenase inhibi-

tors (humans), 531

Neve, K. A., Henningsen, R. A., Kinzie, J.M., de Paulis T., Schmidt, D. E., Kes-sler, R. M. and Janowsky, A.: So-dium-dependent isomerization of do-

pamine D-2 receptors characterized

using [1�IIepidepride, a high-affinity

substituted benzamide ligand, 1108

Newman, M. E., Drummer, D. and Lerer,B.: Single and combined effects of

desimipramine and lithium on sero-

tonergic receptor number and second

messenger function in rat brain, 826

Ngai, J. H., Roth, P. 5. and Paul, R. J.:

Effects of endothelium on basal tone,agonist- and 02-sensitivity in porcine

coronary artery, 1053

Nicklaus, K. J., see Lee, W., 482

Nicolaci, J., see Drummer, 0. H., 1202Nicotine

acute effects on prolactin release (rats),

15

chronic administration, prolactin release

(rats), 21

effect of dose, withdrawal-suppression(humans), 1175

isobolographic characterization, drug in-

teractions, biological variability

(mice), 208role of fourth cerebroventricle, plasma

ACTH responses (rats), 623Nifedipine, gastric proton pump inhibition,

calcium channel antagonists (rab-bits), 1102

Niida, H., see Takeuchi, K., 1228Nikam, S. S., see Killam, A. L., 1083Nitrendipine, catamphiphilic drug uptake,

calcium displacement, erythrocytesand muscular tissue (humans), 333

Nitric oxide, endothelium-derived relaxing

factor, spectrophotometric and bio-logical assays, 922

Nociception, transmission of information inspinal cord, substance P and soma-

tostatin, formalin (mice), 1261Nook, B., see Cicero, T. J., 456

Noradrenalinerelease from adrenal chromaffin cells,

phosphoinositide turnover, cAMPaccumulation, 1296

sodium-dependent release of dopamine,brain synaptosomes (rats), 1283

Norepinephrineacetylcholine release and, inhibition from

neocortex, w-conotoxin GVIA (hu-mans), 778

arterial contraction and Rb-86 efflux,BRL-34915 (rats), 51

cocaine-mediated impairment, cardiacconduction (dogs), 185

inotropic response, prazosin-sensitivecomponent, heart (rabbits), 853

neurally released, potentiation of cardiac

effects, cocaine (cats), 147prejunctional modulation ofrelease, effect

ofage (rats), 159Norgallopamil, norverapamil and, N-glucu-

ronides, 593

Nucleus caudate, substantia nigra and, neu-

rotensin-induced dopamine release(rabbits), 817

Nuki, C., see Kawasaki, H., 403

Oakes, S. G., Schlager, J. J., Santone, K. S.,Abraham, R. T. and Powis, G.: Dox-orubicin blocks the increase in intra-

cellular Ca�, part of a second mes-

senger system in NIE-115 murineneuroblastoma cells, 979

O’Connor, L., see Cicero, T. J., 456O’Donnell, S. R., Wanstall, J. C. and Zeng,

X.-P.: Pinacidil antagonism of endo-thelin-induced contractions of

smooth muscle in the lungs: Differ-

ences between tracheal and pulmo-

nary artery preparations, 1318Ogata, H., see Takahashi, H., 272Ogata, N. and Narahashi, T.: Potent block-

ing action of chlorpromazine on twotypes of calcium channels in cultured

neuroblastoma cells, 11428-OH-DPAT, activation of ventral medul-

lary serotonin receptor subtypes, car-diovascular activity (cats), 665

Ohhashi, T., see Kawai, Y., 1234Ohkubo, T., Shibata, M., Takahashi, H. and

Inoki, R.: Roles of substance P andsomatostatin on transmission of no-

1398 Index Vol. 252

ciceptive information induced by for-maIm in spinal cord, 1261

Ohno, Y. and Warnick, J. E.: Selectivedepression of the segmental polysy-naptic reflex by phencyclidine and itsanalogs in the rat in Vitro: Interac-tion with N-methyl-D-aspartate re-

ceptors, 246Ohyama, T., , see Hayashi, K. 1240Okabe, K., Kajioka, S., Nakao, K., Kits-

mura, K., Kuriyama, H. and Weston,A. H.: Actions of cromakalim on ioniccurrents recorded from single smoothmuscle cells of the rat portal vein,832

Okabe, S., see Takeuchi, K., 1228Okada, M., Mine, K. and Fujiwara, M.: Na�-

dependent release of endogenous do-pamine and noradrenaline from ratbrain synaptosomes, 1283

Okada, M., see Takeuchi, K., 1228Okamura, T., see Teds, N., 374Okano, T., see Tomita, Y., 859Okita, G. T., see Rasmussen, H. H., 60Olley, P. M., see Adeagbo, A. S. 0., 875Opioids

agonists, thermoregulatory set point(rats), 696

antagonists, saline and naltrexone dis-crimination, morphine (monkeys),

600

differential cross-tolerance, shock titra-

tion schedule (monkeys), 845kappa, partial agonist activity, BW942C

(humans, rats, mice, monkeys), 225Ormsbee, H. S., I!!, see Barnette, M. S.,

1160Osnes, J.-B., see Skomedal, T., 853Oases, L., see Fiorica-Howells, E., 610Otterness, D. M., see Hernandez, J. 5., 568Overend, M. F., see Brown, D. R, 126Owen, P. J., see Plevin, R., 1296Oxmetidine, inhibition of liver mitochon-

drial respiration (rats), 908Oxygen

-dependent hepatotoxicity, ethyihexanol,mitochondria (rats), 1355

elevation of diphosphoglycerate level, 2,3-diphosphoglycerate phosphatase/synthase, red blood cells (humans),192

sensitivity, endothelium effects, coronaryartery (pigs), 1053

Oxytocin, phosphoinositide hydrolysis,renal epithelial cells, 552

Paakkari, I., see Paakkari, P., 235Paakkari, P., Paakari, I., Sirmen, A.-L and

Feuerstein, G.: Respiratory and lo-comotor stimulation by low doses ofdermorphin, a Mu1 receptor-me-diated effect, 235

Page, R D. and Yorio, T.: PGF2,, inhibitsacidification ins W secreting epithe-ha, 929

Pancreas, water and bicarbonate secretion,gabexate and camostat (dogs), 320

Pandian, M. R., see Elias, A. N., 384Pang, P. K. T., see Yang, M. C. M., 840Panoutsacopoulou, M., see Maragoudakis,

M. E., 753Parathyroid hormone

mechanisms of vascular action, 840peptide fragments, salmon calcitonin and

morphine, antinociceptive tests(mice), 140

Parietal cellscalcium channel antagonists, mecha-

nisms, gastric proton pump inhibi-

tion (rabbits), 1102inhibition of acid formation, AG-1749

(dogs), 1289Parini, A., see Coupry, I., 293Paroxetine, antidepressant binding sites in

brain (rats), 410Patch clamp

D2 dopamine receptors, calcium channelcurrent, adrenal chromaffin cells (bo-

vine), 586molecular effects of dimethylanatoxin,

peripheral nicotinic acetylchohine re-ceptor, 507

Patel, J., see Mangano, T. J., 574Paul, I. A., Duncan, G. E., Kuhn, C., Muel-

ler, R. A., Hong, J.-S. and Breese, G.R.: Neural adaptation in imipramine-treated rats processed in the forcedswim test: Assessment of time course,handling, rat strain and amine up-take, 997

Paul, R. J., see Ngai, J. H., 1053PC 12 cells, chronic ethanol exposure, aden-

ylate cyclase activity, cAMP content,1021

Peach, M. J., see Tracey, W. R., 922Pegram, B. L., see Scheufler, E., 333Pendleton, R. G., see Yu, K. T., 192Pendley, C., II, see Yu, K. T., 192Peptidases, peptide transport and, renal

brush-border membrane vesicles(rats), 98

Peptides, fragments of parathyroid hor-mone, salmon calcitonin and mor-phine, antinociceptive tests (mice),140

Peptidoleukotrienes, contractile responses,IC! 204,219 blockade, epithehium(guinea pigs), 77

Perico, N., Dadan, J., Gabanelli, M. and

Remuzzi, G.: Cycbooxygenase prod-

ucts and atrial natriuretic peptide

modulate renal response to endothe-lin, 1213

Perindopril, biliary excretion and conjuga-tion (rats), 1202

Perrone, M. H., see Bilder, G. E., 526Persson, C. G. A., see Karlsson, J.-A., 863Pertussis toxin

inhibition of contractions but not relaxa-tions, acetylcholine, pulmonary ar-tery (rabbits), 260

interaction of azepexole and halothane(guinea pigs), 1156

Peters, T., see Scheufler, E., 333Peterson, P. K., see Chao, C. C., 605pH

gastric alkaline secretion, influence ofstress (rats), 1228

inhibition of acidification, W-secretingepithelia, prostaglandin F� (frogs),929

Phencychidine

blockade of voltage-dependent potassiumcurrents, thymocytes (mice), 610

depression, segmental polysynaptic reflex(rats), 246

discriminative stimulus properties, self-

administration, MK-801 (monkeys),953

-like behavioral effec