Faculty of Chemistry University of Belgrade
Center for Chemistry
Institute for Chemistry,
Technology and Metallurgy
Belgrade
Laboratory for Instrumental Analysis (founded 1966), former Center for Instrumental Analysis = “CIA”
accredited to ISO 17025 standard
Studentski trg 12 - 16 Belgrade, Serbia
Prof. Milutin
Stefanović
1924 - 2009
Prof. Dragoslav
Jeremić
Dr. Vlatka Vajs
Dr. Vele Tešević
Dr. Nina Todorović
Dr. Snežana Trifunović
Dr. Ivan Vučković
Dr. Dejan Gođevac
Miroslav Novaković,
M. Sci.
Milka Jadranin, M.Sci.
Danica Bajić
Marina Blagojević
Dejan Vučetić
Dr. Iris Djordjević
Dr. Ivana Aljančić Boris Mandić, M.Sci.
Ljubodrag Vujisić,
M.Sci. Boris Mandić, M.Sci.
Dr. Slobodan Milosavljević
LC/MS ESI TOF
500 MHz NMR FT IR
GC/MS
Equipment of CIA
Activities of CIA:
1. Service: running spectra, chromatograms and microanalysis interpretation of spectra miscellaneous (Police, Medicine and Medical Devices
Agency of Serbia)
UV
NMR
IR
2. Teaching: • “Structural instrumental methods” • “Chemistry of secondary metabolites”
O
CH3
Cl
Example of an exam problem for
a third-year student of chemistry
MS
13C NMR
1H NMR
UV
IR
3. Phytochemistry Scientific project (No 172053, Ministry of Science and Technological Development, Serbia): “Bioactive natural products of wild-growing, cultivated and edible plants: structure and bioctivity determination”
Mountain Orjen, Montenegro 2006
Photo smilo
Dr. Vlatka Vajs
•Institute for Medicinal Plant Research “Dr Josif Pančić", Belgrade
•Botanic Garden Dulovine, Kolašin, Montenegro
•Mayo Clinic Rochester, Minnesota, USA
•Faculty of Biology, University of Belgrade
•Faculty of Pharmacy, University of Belgrade
•Institute for Biological Research “Siniša Stanković”, Belgrade
•Faculty of Natural Sciences and Mathematics, Niš
•School of Medicine, University of Belgrade
•The Institiute for Oncology and Radiology, Belgrade
•The Institute for Nuclear Sciences, Vinča
•Faculty of Science, Podgorica
•National Park, Galičica, Ohrid
Collaboration with the following institutions :
Joint project of Serbian Academy of Sciences and Arts
and Bulgarian Academy of Sciences: "Natural products
from plants and marine organisms: medicinal and
ecological significance".
1. Asteraceae: Achillea (11), Ambrosia (1), Amphoricarpos (2), Anthemis
(6), Artemisia (7), Centaurea (8), Cicerbita (2), Eupatorium (1), Inula (3),
Senecio (7), Ptilostemon (2), Tanacetum (6), Telekia (1)
2. Apiaceae: Angelica (1), Athamanta (1), Cherophyllum (1), Laserpitium
(4), Peucedanum (1), Seseli (3)
3. Gentianaceae: Gentiana (2), Gentianella (5), Swertia (1)
4. Guttiferae: Hypericum (4)
5. Lamiaceae: Lycopus (1), Phlomis (1)
6. Dipsacaceae: Cephalaria (3)
7. Boraginaceae: Rindera (1)
Phytochemical investigations: studied genera
initiated by M. Stefanović and D. Jeremić by the
beginning of seventies
Artemisia annua L. O
O
OO
O
H
H
Artemisinin
8. Anacardiaceae: Cotinus (1)
Serbia and Montenegro
•Galičica, Ohrid
Macedonia
Phytochemistry
•Tara mountain
•Montenegro mountains
•Šar-Planina, (Šara Mountain)
•Sićevačka klisura (Sićevo
gorge)
•Stara Planina (Old mountain)
•Deliblatska peščara (Deliblato
sand)
Sesquiterpene
lactones
O
O
RO
H
H
OH
R1
O
OH
MeO
MeO
R3'
OR4'
O
OMe
Flavonoids
O
O
R5
OR8
R3O
OR1
R7
O
O
OGlc
H
O
CH2OH
R1O
O
OR2
R1= β-D-Xyl(1-3)- α-L-Rha(1-2)- α-L-Ara-
R2= β-D-Glc-
Triterpenoid
saponins
Xanthones Secoiridoids H H
O
OHO
O
1
23
4
5
6
78
9
10
1'
2'
3'
4'
5'
6'
1" 2"
3"
1''' 2'''
3'''
4'''5'''
4"
Prenylated
phloroglucinols N
OO
1R
O
R2O
O OO
OMe
Coumarins Pyrrolizidine alkaloids
Compounds
1. Antibacterial
2. Antifungal
3. Cytotoxic
4. Тubuline test
4. Radioprotective
5. Antioxidative
Bioactivities
Recent topics
Grape seeds
Vitis vinifera
Еxtr.: EtOAc + H2O (10%)
LC/UV/ESI-TOF MS 13C NMR
17 polyphenols
Antioxidants in healthy food of Balcans
HPLC of grape seed
extract
13C NMR of grape seed
extract
M. Stanković et al., "Antioxidant properties
of grape seed extract on human lymphocyte
oxidative defence", Planta Medica, 74, 730-
735 (2008)
1. R. Matović, R. N. Saičić: An efficient semisynthesis of 7-deoxypaclitaxel
from taxine, J. Chem. Soc., Chem. Commun. 1998, 1745-1746.
2. R. N. Saičić, R. Matović, Ž. Čeković: Semisynthesis of Taxol: an
improved procedure for the isolation of 10-deacetylbaccatin III, J. Serb.
Chem. Soc. 1999, 64, 497-503; Natural Products Updates 2000,
34343.
3. R. N. Saičić, R. Matović: An efficient semisynthesis of 7-deoxypaclitaxel
from taxine, J. Chem. Soc., Perkin Trans. 1, 2000, 59-65.
4. Z. Ferjančić, R. Matović, Z. Čeković, J. P. Snyder and R. N. Saičić:
Synthesis, biological evaluation and modeling of a C,D-seco-taxoid,
Tetrahedron Lett. 2005, 46, 5049-5052.
5. Z. Ferjančić, R. Matović, Ž. Čeković, Y. Jiang, J. P. Snyder, V. Trajković
and R. N. Saičić: Synthesis, biology and modeling of C-4 carbonyl C,D-
seco-taxoid, Tetrahedron 2006, 62, 8503-8514.
6. Z. Ferjančić, R. Matović, Ž. Čeković and R. N. Saičić: Reactions of -
4(20)-epoxy-5-O-mesyltriacetyltaxicine I induced by BF3•Et2O/Bu4NBr,
J. Serb. Chem. Soc. 2006, 71, 705-711.
dr. Radomir N. Saičić
Organic Synthesis
A view of Prokletije mountains (over Plav lake), Montenegro
Photo smilo
The End
