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List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

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The pale hand of a woman with severe anemia (right) in comparison to the normal hand of her husband (left) List of hematologic conditions From Wikipedia, the free encyclopedia This is an incomplete list, which may never be able to satisfy certain standards for completion. There are many conditions of or affecting the human Hematologic system — the Biological system that includes plasma, platelets, leukocytes, and erythrocytes, the major components of blood and the bone marrow. [1] Contents 1 Anemias 1.1 Nutritional anemias 1.2 Haemolytic, Aplastic and other anemias 2 Blood cancers 2.1 Lymphoma 2.2 Leukemia 2.3 Myeloma 2.4 Malignant immunoproliferative diseases 3 Coagulation, purpura, and other hemorrhagic conditions 4 Infection-related 4.1 Bacterium-related 4.2 Protozoan-related 5 Immune system regulation-related 5.1 Immunodeficiency with predominantly antibody defects 6 References Anemias Main article: Anemia An anemia is a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. [2][3] However; it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency. Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying causes. Anemia can be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, to mention a few. The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low- volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis). Based on 2005- 2006 estimates, the Centers for Disease Control and Prevention, has stated that approximately 5.5 million Americans a year are either admitted to a hospital or seen by a physician, with some form of anemia as their primary diagnosis. [4] Nutritional anemias A nutritional anemia refers to a type of anemia that can be directly attributed to either a nutritional disorder or a nutritional deficiency. Condition name ICD-10 coding number Diseases Database coding number Medical Subject Headings Iron deficiency anemia D50. (http://apps.who.int/classifications/apps/icd/icd10online/? gd50.htm+d50) 6947 (http://www.diseasesdatabase.com/ddb6947.htm) Iron deficiency anemia (or iron deficiency anaemia) is a common anemia that occurs when iron loss (often from intestinal bleeding or menses) occurs, and/or the dietary intake or absorption of iron is insufficient. In such a state, hemoglobin, which contains iron, cannot be formed. [5] Plummer-Vinson syndrome D50.1 (http://apps.who.int/classifications/apps/icd/icd10online/? gd50.htm+d501) 10134 (http://www.diseasesdatabase.com/ddb10134.htm) Plummer-Vinson syndrome (PVS), also called Paterson-Brown-Kelly syndrome or sideropenic dysphagia presents as a triad of dysphagia (due to esophageal webs), glossitis, and iron deficiency anemia. [6] It most usually occurs in postmenopausal women. Vitamin B12 deficiency anemia E53.8 (http://apps.who.int/classifications/apps/icd/icd10online/? ge50.htm+e538) 13905 (http://www.diseasesdatabase.com/ddb13905.htm) Vitamin B12 deficiency anemia occurs when a "lower-than-normal" amount of the vitamin B12 is available within the body, leading to a decreased production of healthy red blood cells. [7]
Transcript
Page 1: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

The pale hand of a woman withsevere anemia (right) incomparison to the normal hand ofher husband (left)

List of hematologic conditionsFrom Wikipedia, the free encyclopedia

This is an incomplete list, which may never be able to satisfy certain standards for completion.

There are many conditions of or affecting the human Hematologic system — the Biological system that includes plasma, platelets, leukocytes, and erythrocytes, the majorcomponents of blood and the bone marrow.[1]

Contents

1 Anemias1.1 Nutritional anemias1.2 Haemolytic, Aplastic and other anemias

2 Blood cancers2.1 Lymphoma2.2 Leukemia2.3 Myeloma2.4 Malignant immunoproliferative diseases

3 Coagulation, purpura, and other hemorrhagic conditions4 Infection-related

4.1 Bacterium-related4.2 Protozoan-related

5 Immune system regulation-related5.1 Immunodeficiency with predominantly antibody defects

6 References

Anemias

Main article: Anemia

An anemia is a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood.[2][3] However; itcan include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in someother types of hemoglobin deficiency.

Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying causes. Anemiacan be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, tomention a few. The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low-volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis). Based on 2005-2006 estimates, the Centers for Disease Control and Prevention, has stated that approximately 5.5 million Americans a year are eitheradmitted to a hospital or seen by a physician, with some form of anemia as their primary diagnosis.[4]

Nutritional anemias

A nutritional anemia refers to a type of anemia that can be directly attributed to either a nutritional disorder or a nutritional deficiency.

Condition name ICD-10 coding number Diseases Database coding numberMedicalSubject

Headings

Iron deficiency anemiaD50.(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d50)

6947(http://www.diseasesdatabase.com/ddb6947.htm)

Iron deficiency anemia (or iron deficiency anaemia) is a common anemia that occurs when iron loss (often from intestinal bleeding or menses) occurs, and/or the dietary intake orabsorption of iron is insufficient. In such a state, hemoglobin, which contains iron, cannot be formed.[5]

Plummer-Vinson syndromeD50.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d501)

10134(http://www.diseasesdatabase.com/ddb10134.htm)

Plummer-Vinson syndrome (PVS), also called Paterson-Brown-Kelly syndrome or sideropenic dysphagia presents as a triad of dysphagia (due to esophageal webs), glossitis, andiron deficiency anemia.[6] It most usually occurs in postmenopausal women.

Vitamin B12 deficiency anemiaE53.8(http://apps.who.int/classifications/apps/icd/icd10online/?ge50.htm+e538)

13905(http://www.diseasesdatabase.com/ddb13905.htm)

Vitamin B12 deficiency anemia occurs when a "lower-than-normal" amount of the vitamin B12 is available within the body, leading to a decreased production of healthy red bloodcells.[7]

Page 2: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

Vitamin B12 deficiency anemia due to intrinsic factordeficiency

D51.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d510)

vitamin B12 deficiency is caused by a lack of intrinsic factor, as seen in pernicious anemia, causes a vitamin B12 deficiency

Pernicious anemiaD51.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d510)

9870(http://www.diseasesdatabase.com/ddb9870.htm)

Pernicious anemia (also known as Macrocytic achylic anemia, Congenital pernicious anemia, Juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of thelarger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Pernicious anemia is the result of inadequate

production of the protein intrinsic factor needed by the body to absorb vitamin B 12, causing a reduction of new red blood cells.[8]

Vitamin B 12 deficiency anemia due to selectivevitamin B 12 malabsorption with proteinuria

Vitamin B 12 deficiency anemia due to selective vitamin B 12 malabsorption with proteinuria (also known as Imerslund-Gräsbeck syndrome) is a rare autosomal recessivedisorder which requires the indefinite administration of Vitamin B12 injections.[9]

Megaloblastic hereditary anemia

D51.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d511) , D52.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d520) , D53.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d531)

29507(http://www.diseasesdatabase.com/ddb29507.htm)

Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production.[10]

Transcobalamin II deficiencyD51.2(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d512)

Transcobalamin II deficiency (TCII) (also known as hereditary transcobalamin II deficiency) is a rare autosomal recessive disorder that results in neurological dysfunction.[11]

Transcobalamin II are a type of carrier proteins which bind with plasma vitamin B12 (cobalamin) in the production of red blood cells.[12]

Folate-deficiency anemia

D52.(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d52) E53.8(http://apps.who.int/classifications/apps/icd/icd10online/?ge50.htm+e538)

4894(http://www.diseasesdatabase.com/ddb4894.htm)

Folate-deficiency anemia (also known as dietary folate-deficiency anemia) is a condition that develops when the body does not have the adequate supply of folic acid available thatis needed for the production of new healthy blood cells.[13]

Nutritional megaloblastic anemia

D51.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d511) , D52.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d520) , D53.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d531)

29507(http://www.diseasesdatabase.com/ddb29507.htm)

D000749

Nutritional Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production.[10]

Drug-induced folate deficiency anemiaD52.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d521)

Protein deficiency anemia

Protein deficiency anemia is an anemia that results from an inadequate intake of dietary protein.[14]

ScurvyE54.(http://apps.who.int/classifications/apps/icd/icd10online/?ge50.htm+e54)

13930(http://www.diseasesdatabase.com/ddb13930.htm)

Scurvy is a disease resulting from a deficiency of vitamin C,[15] which is required for the synthesis of collagen in humans.

Haemolytic, Aplastic and other anemias

Condition name ICD-10 coding number Diseases Database coding numberMedicalSubject

Headings

Acanthocytosis

Acanthocytosis (also known as Abetalipoproteinemia, Apolipoprotein B deficiency, and Bassen-Kornzweig syndrome) is a rare, genetically inherited, autosomal recessive

Page 3: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

condition that causes the inability to fully digest dietary fats in the intestines. The gene responsible for this condition is the microsomal triglyceride transfer protein gene.[16]

Acute posthemorrhagic anemiaD62.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d620)

Acute posthemorrhagic anemia (also known as acute blood loss anemia) is a condition in which a person quickly loses a large volume of circulating hemoglobin. Acute blood lossis usually associated with an incident of trauma or a severe injury resulting in a large loss of blood. It can also occur during or after a surgical procedure.[17]

Alpha-thalassemia

D56.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d560)

448(http://www.diseasesdatabase.com/ddb448.htm) ,33334(http://www.diseasesdatabase.com/ddb33334.htm), 33678(http://www.diseasesdatabase.com/ddb33678.htm)

Alpha-thalassemia (α-thalassemia) is a form of thalassemia involving the genes HBA1 [18] and HBA2.[19] It is condition that causes a reduction of hemoglobin production. Thereare two types of Alpha-thalassemia named hemoglobin Bart hydrops fetalis syndrome (also known as Hb Bart syndrome) and HbH disease.[20]

Anemia

D50.(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d50) -D64.(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d64)

663(http://www.diseasesdatabase.com/ddb663.htm)

Anemia is a general medical term used to describe a number of conditions that result in a decrease in the number of red blood cells (RBCs) or less than the normal quantity ofhemoglobin in the blood.[2]

Anemia of chronic disease

Anemia of chronic disease (ACD) (also known as anemia of inflammatory response) is a condition where the body converts iron into unused ferrin, causing a drop in hemoglobinproduction, and as a result; decreased red blood cell production and count. This is caused by a natural defense mechanism initiated by an inflammatory response in response to theunderlying chronic disease.[21]

Anemia in Kidney Disease and Dialysis

Anemia in Kidney Disease and Dialysis results from the diseased kidney's inability to produce enough of the hormone erythropoietin. Erythropoietin is used to stimulate anadequate production of red blood cells from the bone marrow.[22]

Anemia of prematurityP61.2(http://apps.who.int/classifications/apps/icd/icd10online/?gp50.htm+p612)

Anemia of prematurity refers to a form of anemia affecting preterm infants[23] with decreased hematocrit.[24]

Aplastic anemia

D60.(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d60) -D61.(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d61)

866(http://www.diseasesdatabase.com/ddb866.htm)

Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells.[25]

Autoimmune hemolytic anemia

D59.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d590) -D59.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d591)

Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction(hemolysis).[26][27] Types of AIHA include Warm autoimmune hemolytic anemia, Cold agglutinin disease, and Paroxysmal cold hemoglobinuria.

Beta-thalassemiaD56.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d561)

3087(http://www.diseasesdatabase.com/ddb3087.htm)

Beta-thalassemia (β-thalassemia) is an autosomal dominant blood condition that results in the reduction of hemoglobin production. The cause for the disorder is related to a geneticmutation of the HBB gene. This gene is responsible for providing the instructions to produce beta-globin; one of the major components of hemoglobin. The two classification typesof beta thalassemia are thalassemia major (also known as Cooley's anemia) and thalassemia intermedia.[28]

Diamond-Blackfan anemiaD61.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d610)

29062(http://www.diseasesdatabase.com/ddb29062.htm)

Diamond–Blackfan anemia (DBA), (also known as Blackfan–Diamond anemia and Inherited erythroblastopenia) [29] is a congenital erythroid aplasia that usually presents ininfancy.[30]

Congenital dyserythropoietic anemiaD64.4(http://apps.who.int/classifications/apps/icd/icd10online/?

Page 4: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

gd60.htm+d644)

Congenital dyserythropoietic anemia (CDA) is a generically inherited autosomal recessive (types I and II) or autosomal dominant (type III) blood disorder that effects the normalmaturation process of red blood cell production. Mutations to the CDAN1 gene (type I), SEC23B gene (type II), and a currently unknown gene for type III causes a disruption inthe normal formation of erythropoiesis, thereby causing a reduction of circulating healthy mature red blood cells.[31]

Drug-induced autoimmune hemolytic anemiaD59.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d590)

Drug-induced autoimmune hemolytic anemia is a type of hemolytic anemia in which a mediated immune response triggers IgG and IgM antibody production in regards to thepresence of high doses of penicillin via the hapten mechanism causing the reduction of red blood cells in the spleen.[32]

Drug-induced nonautoimmune hemolytic anemia

Glucose-6-phosphate dehydrogenase deficiencyD55.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d550)

19674(http://www.diseasesdatabase.com/ddb19674.htm)

D005955

HemoglobinopathyD58.2(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d582)

5037(http://www.diseasesdatabase.com/ddb5037.htm)

Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule.[33] Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits.[34] Hemoglobinopathies imply structural abnormalities in the globin proteins themselves.[35]

Hemoglobinopathy variants include sickle-cell disease.[36]

Hemolytic anemia

D55.(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d55) -D59.(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d59)

5534(http://www.diseasesdatabase.com/ddb5534.htm)

Hemolytic anemia (also known as haemolytic anaemia) is an anemia due to hemolysis, the abnormal breakdown of red blood cells. A number of different mediating factors cancause this condition; either from within the blood cell itself ((intrinsic factors) or outside of the cell (extrinsic factors).[37]

Congenital hemolytic anemia

Fanconi's anemiaD61.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d610)

4745(http://www.diseasesdatabase.com/ddb4745.htm)

D005199

Fanconi's anemia is a rare genetic autosomal recessive aplastic anemia that involves chromosomes 9q and 20q.[38]

Hereditary spherocytosisD58.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d580)

5827(http://www.diseasesdatabase.com/ddb5827.htm)

Hereditary spherocytosis is a genetically-transmitted (autosomal dominant) form of spherocytosis, an auto-hemolytic anemia characterized by the production of red blood cells thatare sphere-shaped rather than bi-concave disk shaped (Donut-Shaped), and therefore more prone to hemolysis.[39]

Hereditary elliptocytosisD58.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d581)

4172(http://www.diseasesdatabase.com/ddb4172.htm)

Hereditary elliptocytosis (HE) (also known as ovalocytosis), is an inherited blood disorder in which an abnormally large number of circulating red blood cells are elliptical or cigarshaped rather than the typical biconcave disc shape. It is caused in part by mutations in the formation of specific Spectrin tetramers or proteins responsible for giving the red bloodcell its shape and elasticity causing continued deformation as the cell matures.[40] Subtypes of this condition include southeast Asian ovalocytosis and spherocytic elliptocytosis.

Hereditary pyropoikilocytosis

Hereditary pyropoikilocytosis (HPP) is an autosomal recessive form of hemolytic anemia which typically presents at infancy or early childhood, characterized by abnormal redblood cell morphology including "budding red cells, fragmented red cells, spherocytes, elliptocytes, triangular cells, and other bizarre-shaped red cells." [41]

Acquired hemolytic anemia

Cold hemagglutinin diseaseD59.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d591)

2949(http://www.diseasesdatabase.com/ddb2949.htm)

Cold hemagglutinin disease (also known as cold agglutinin disease and autoimmune anemia due to cold-reactive antibodies)is an autoimmune disease characterized by the presenceof high concentrations of circulating antibodies, usually IgM, directed against red blood cells.[42] It is a form of autoimmune hemolytic anemia, specifically one in which antibodiesonly bind red blood cells at low body temperatures, typically 28-31°C.

Paroxysmal cold hemoglobinuriaD59.6(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d596)

9679(http://www.diseasesdatabase.com/ddb9679.htm)

Paroxysmal cold hemoglobinuria (PCH) (also known as Donath-Landsteiner syndrome) is a rare condition characterized by the sudden presence of hemoglobin in the urine (called[43]

Page 5: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

hemoglobinuria), typically after exposure to cold temperatures.[43]

Hemolytic-uremic syndromeD59.3(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d593)

13052(http://www.diseasesdatabase.com/ddb13052.htm)

Hemolytic-uremic syndrome (HUS) (also known as haemolytic-uraemic syndrome) is a disease characterized by hemolytic anemia, acute renal failure (uremia) and a low plateletcount (thrombocytopenia). It predominantly but not exclusively affects children. Most cases are preceded by an episode of diarrhea caused by E. coli O157:H7, which is acquiredas a foodborne illness.[44]

Hereditary persistence of fetal hemoglobin

Hereditary stomatocytosis | |D58.8(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d588)

29710(http://www.diseasesdatabase.com/ddb29710.htm)

Hereditary stomatocytosis describes a number of inherited autosomal dominant human conditions which affect the red blood cell, in which the membrane or outer coating of the cell'leaks' sodium and potassium ions, causing cell lyses and eventual haemolytic anaemia.

Hexokinase deficiencyD55.2(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d552)

Hexokinase deficiency (also known as human erythrocyte hexokinase deficiency) is an anemia-causing condition associated with inadequate hexokinase.[45]

Hyperanaemia

Hypochromic anemia

Hypochromic anemia is a generic term for any type of anemia in which the red blood cells (erythrocytes) are paler than normal.[46] This is caused by a proportionally reducedamount of hemoglobin present in relation to the size of the red blood cell.

Ineffective erythropoiesis

Ineffective erythropoiesis is an anemia caused by the premature apoptosis of the body's mature red blood cells [47] and subsequent reduction in an adequate production and fullmaturation of new healthy red blood cells.[48]

Macrocytic anemia

Megaloblastic anemia

D51.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d511) , D52.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d520) , D53.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd50.htm+d531)

29507(http://www.diseasesdatabase.com/ddb29507.htm)

Megaloblastic anemia (or megaloblastic anaemia) is an anemia of macrocytic classification that results from inhibition of DNA synthesis in red blood cell production.[10]

Microangiopathic hemolytic anemia

Minkowski-Chauffard syndrome

Myelophthisic anemiaD61.9(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d619)

Myelophthisic anemia (also known as myelophthisis) is a severe kind of anemia found in some people with diseases that affect the bone marrow. Myelophythisis refers to thedisplacement of hemopoietic bone-marrow tissue into the peripheral blood,[49] either by fibrosis, tumors or granulomas.

Neuroacanthocytosis29707(http://www.diseasesdatabase.com/ddb29707.htm)

D054546

Neuroacanthocytosis (also known as Levine-Critchley syndrome) are a group of rare, genetic conditions that are characterized by movement disorders and acanthocytosis.[50]

Chorea acanthocytosis29707(http://www.diseasesdatabase.com/ddb29707.htm)

D054546

Chorea-acanthocytosis (ChAc)(also known as Levine-Critchley syndrome, acanthocytosis with neurologic disorder, neuroacanthocytosis, and choreoacanthocytosis)[51] is a rarehereditary disease caused by a mutation of the gene that directs structural proteins in red blood cells. It belongs to a group of four diseases characterized asneuroacanthocytosis.[52]

Non sideropenic hypochromic anaemia

Normocytic anemia

A normocytic anemia is a general term for an anemia with an Mean corpuscular volume (MCV) of 80-100.

Paroxysmal nocturnal hemoglobinuriaD59.5(http://apps.who.int/classifications/apps/icd/icd10online/?d55 h d595)

9688

(htt // di d t b /ddb9688 ht )

Page 6: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

Seven-year-old Nigerian boy withBurkitt's lymphoma presentingwith a severely ulcerated andswollen jaw.

gd55.htm+d595) (http://www.diseasesdatabase.com/ddb9688.htm)

Paroxysmal nocturnal hemoglobinuria (also known as Marchiafava-Micheli syndrome) is a rare, acquired

Pyruvate kinase deficiencyD55.2(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d552)

11090(http://www.diseasesdatabase.com/ddb11090.htm)

Pyruvate kinase deficiency, also called erythrocyte pyruvate kinase deficiency,[53] is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of redblood cells and causes them to deform into echinocytes on peripheral blood smears.

Rh deficiency syndrome

Rh deficiency syndrome is a type of hemolytic anemia that involves erythrocytes whom membranes are deficient in Rh antigens. It is considered a rare condition.[54]

Sickle-cell disease

Sideroblastic anemia

D64.0(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d640) -D64.3(http://apps.who.int/classifications/apps/icd/icd10online/?gd60.htm+d643)

12110(http://www.diseasesdatabase.com/ddb12110.htm)

Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes).[55] It may becaused either by a genetic disorder or indirectly as part of myelodysplastic syndrome.[56]

Southeast Asian ovalocytosisD58.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d581)

9416(http://www.diseasesdatabase.com/ddb9416.htm)

Southeast Asian ovalocytosis (also known as Stomatocytic ovalocytosis, stomatocytic elliptocytosis, and Melanesian ovalocytosis) is a form of hereditary elliptocytosis common insome communities in Malaysia and Papua New Guinea, as it confers some resistance to cerebral Falciparum Malaria.[57]

Spur cell hemolytic anemia

Spur cell hemolytic anemia is a form of hemolytic anemia that results when free cholesterol binds to the red blood cell's membrane increasing its surface area, causing laterdeformities such as rough or thorny projections on the erythrocyte named acanthocytes. This condition is caused by the deceased liver's decreased ability to esterificatecholesterol.[58]

ThalassemiaD56.(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d56)

D013789

Triosephosphate isomerase deficiencyD55.2(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d552)

30116(http://www.diseasesdatabase.com/ddb30116.htm)

Triosephosphate isomerase (TPI) deficiency is a genetically inherited autosomal recessive condition "characterized bychronic hemolytic anemia, cardiomyopathy, susceptibility toinfections, severe neurological dysfunction, and, in most cases, death in early childhood." [59]

Warm autoimmune hemolytic anemiaD59.1(http://apps.who.int/classifications/apps/icd/icd10online/?gd55.htm+d591)

29723(http://www.diseasesdatabase.com/ddb29723.htm)

Warm autoimmune hemolytic anemia is an autoimmune hemolytic anemia (AIHA) characterized by formation of antibodies that attack the body's own red blood cells in adestructive immune system response.[60]

Blood cancers

A blood cancer or hematological malignancy is a type of malignant cancer that originates, affects, or involves the blood, bone marrow, orlymph nodes.[61] These cancers include leukemias, lymphomas, and myelomas. These particular types of cancers can arise as defectedmature cell types that have differentiated from hematopoietic precursor cells (often in the bone marrow) and begin to quickly proliferatethrough the bloodstream where it can then often infiltrate other organs and tissues. Others can involve the formation of tumors fromlymphoblasts from within the lymphoid tissue.[62] Incidences of affected people with a form of blood cancer has been steady increasing overrecent years; however, due in part to early detection methods and subsequent advancements in the treatment of the diseases, mortality rateshave continued to decrease.[63]

Lymphoma

Condition name ICD-10 coding number

DiseasesDatabase

codingnumber

MedicalSubject

Headings

C81

Page 7: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

Hodgkin lymphomaC81.(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c81)

5973

Non-Hodgkin lymphoma

C82.(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c82) -C85.(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c85)

9065

The non-Hodgkin lymphomas (NHLs) are a diverse group of blood cancers that include any kind of lymphoma except Hodgkin's lymphomas.[64]

Anaplastic large cell lymphoma

Angioimmunoblastic T-cell lymphomaC84.4(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c844)

Angioimmunoblastic T-cell lymphoma (AILT) (also known as Angioimmunoblastic lymphadenopathy with dysproteinemia) [65]:747) is a mature T-cell lymphoma with systemiccharacterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemicinvolvement.[66] It is also known as immunoblastic lymphadenopathy (Lukes-Collins Classification) and AILD-type (lymphogranulomatosis X) T-cell lymphoma (KielClassification) [66]

Hepatosplenic T-cell lymphoma

Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver, spleen, and bonemarrow.[67] It is a rare and generally incurable form of lymphoma.[68]

B-cell lymphoma

reticuloendotheliosis

reticulosis

Microglioma

Diffuse large B-cell lymphoma

Follicular lymphomaC82.(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c82)

Follicular Lymphoma also known as (indolent follicular lymphoma) is a type of non-hodgkin's lymphoma that involves both large and small B-cell lymphocytes that spreads fromthe lymphatic system and into the blood, bone marrow, and internal organs. Approximately 20 to 30 percent of non-hodgkin's lymphomas are diagnosed as follicular lymphoma,with a majority of cases involving those 60 years of age or older.[69]

Mucosa-Associated Lymphatic Tissue lymphoma 31339

Mucosa-Associated Lymphatic Tissue lymphoma (as known as MALT lymphoma and extra-nodal marginal zone lymphoma) is a condition in which lymphatic tissue abnormallypresents outside the lymphatic system (extra-nodular) and instead within the mucosa of the gastrointestinal tract, typically as a lesion in the stomach.[70]

B-cell chronic lymphocytic leukemiaC91.1(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c911)

2641

B-cell chronic lymphocytic leukemia (also known as small cell lymphocytic lymphoma) is a blood cancer that involves the B-cell lymphocytes; responsible for the creation ofantibodies. Of the two general types of chronic lymphocytic leukemias (the other involving T-cells), B-cell chronic lymphocytic leukemia accounts for approximately 95 percent ofthe diagnoses.[71]

Mantle cell lymphomaC85.7(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c857)

Mantle cell lymphoma (MCL) is a type of B-cell lymphoma an and one of the rarest forms of non-Hodgkin's lymphomas comprising approximately 6% of diagnosed cases.[72]

Burkitt lymphoma

C83.7(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c837)

1784

Burkitt lymphoma (also known as Burkitt's tumor, Burkitt lymphoma or malignant lymphoma, Burkitt's type) is a type of B-cell lymphoma that is categorized into one of varianttypes. These are variants are endemic (occurring in equatorial Africa), sporadic ("non-African"), and immunodeficiency-associated (usually associated with HIV).

Mediastinal large B cell lymphoma

Waldenström's macroglobulinemiaC88.0(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c880)

14030

Waldenström's macroglob line (also kno n as l mphoplasmac tic l mphoma) is a l mphoproliferati e disease that in ol es an abnormal increase of l mphoc tes ithin the bone

Page 8: List of Hematologic Conditions - Wikipedia, The Free Encyclopedia

Waldenström's macroglobuline (also known as lymphoplasmacytic lymphoma) is a lymphoproliferative disease that involves an abnormal increase of lymphocytes within the bonemarrow, creasing disruption of normal red blood cell production.[73]

Nodal marginal zone B cell lymphoma

Splenic marginal zone lymphoma

Splenic marginal zone lymphoma (SMZL) (also known as well-differentiated lymphocytic lymphoma, small lymphocytic lymphoma, and splenic lymphoma with circulating villouslymphocytes) is a lymphoma made up of small B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes andlarger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. Frequently, the bonemarrow and splenic hilar lymph nodes are involved along with the peripheral blood.[74]

Intravascular large B-cell lymphoma

Primary effusion lymphoma 33904

Primary effusion lymphoma is a condition caused by Kaposi's sarcoma-associated herpesvirus (KSHV) [75]

Lymphomatoid granulomatosis

Nodular lymphocyte predominant Hodgkin's lymphoma

Leukemia

Condition name ICD-10 coding number

DiseasesDatabase

codingnumber

MedicalSubject

Headings

plasma cell leukemiaC90.1(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c901)

D007952

Plasma cell leukemia (PCL), a lymphoproliferative disorder,[76] is a rare cancer involving a subtype of white blood cells called plasma cells.[77]

Acute erythraemia and erythroleukaemia

Acute erythremic myelosis

Acute erythroid leukemiaC94.0(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c940)

Acute erythroid leukemia (also known as Guglielmo's disease, and acute Di Guglielmo syndrome) is a rare form of acute myeloid leukemia.

Heilmeyer-Schöner disease

Acute megakaryoblastic leukemia D007947

Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia where megakaryoblasts account for approximately 30% of the nucleated cells within the bonemarrow.[78]

Acute megakaryoblastic leukemia

Mast cell leukemia

PanmyelosisC94.4(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c944)

Acute panmyelosis with myelofibrosisC94.4(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c944)

Acute panmyelosis with myelofibrosis (APMF) is a poorly-defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow.

Lymphosarcoma cell leukemia

Acute leukaemia of unspecified cell type

Blastic phase chronic myelogenous leukemia

Blastic phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which more than 30% of the cells in the blood or bone marrow are blast cells.

Stem cell leukemia

Chronic leukaemia of unspecified cell type

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Subacute leukaemia of unspecified cell type

Accelerated phase chronic myelogenous leukemia

Acute myeloid leukemiaC92.0(http://apps.who.int/classifications/apps/icd/icd10online/?gc81.htm+c920)

203

Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal whiteblood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.[79]

Acute promyelocytic leukemia

Acute basophilic leukemia

Acute eosinophilic leukemia

Acute lymphoblastic leukemia

Acute monocytic leukemia

Acute myeloblastic leukemia with maturation

Acute myeloid dendritic cell leukemia

Adult T-cell leukemia/lymphoma

Aggressive NK-cell leukemia

B-cell prolymphocytic leukemia

B-cell chronic lymphocytic leukemia

B-cell leukemia

Chronic myelogenous leukemia

Chronic myelomonocytic leukemia

Chronic neutrophilic leukemia

Hairy cell leukemia

Myeloma

Condition name ICD-10 coding numberDiseasesDatabase

coding number

MedicalSubject

Headings

Multiple myeloma

Kahler's disease

Myelomatosis

solitary myeloma

Plasma cell leukaemia

Plasmacytoma, extramedullary

Malignant plasma cell tumour NOS

Plasmacytoma NOS

Solitary myeloma

Malignant immunoproliferative diseases

Di M di l

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Condition name ICD-10 coding numberDiseasesDatabase

coding number

MedicalSubject

Headings

Monoclonal gammopathy

Angiocentric immunoproliferative lesion

Lymphoid granulomatosis

Angioimmunoblastic lymphadenopathy

T-gamma lymphoproliferative disease

Waldenström's macroglobulinaemia

Alpha heavy chain disease

Gamma heavy chain disease

Franklin's disease

Immunoproliferative small intestinal disease

Mediterranean disease

Malignant immunoproliferative disease, unspecified

Immunoproliferative disease NOS

Coagulation, purpura, and other hemorrhagic conditions

Condition name ICD-10 coding number

DiseasesDatabase

codingnumber

MedicalSubject

Headings

Disseminated intravascular coagulation (DIC, Defibrination syndrome)

Protein C deficiency

Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease.[80]

Protein S deficiency

Thrombocytosis

Idiopathic thrombocytopenic purpuraD69.3(http://apps.who.int/classifications/apps/icd/icd10online/?gd65.htm+d693)

6673 D016553

Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count (thrombocytopenia) of no known cause (idiopathic).

Recurrent thrombosis

Hemophilia

Hemophilia A

Hemophilia B

Hemophilia C

Von Willebrand disease

Antiphospholipid syndrome

Thrombocytopenia

Glanzmann's thrombasthenia

Wiskott Aldrich syndrome

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Infection-related

Hematological disorders may be caused by a number of infection-related conditions involving the introduction of microorganisms into the host, such as bacteria and protozoa.[38]

Bacterium-related

Condition name ICD-10 coding numberDiseasesDatabase

coding number

MedicalSubject

Headings

Clostridium infection

Cholera infection

E. coli 0157:H7 infection

Typhoid fever

Protozoan-related

Condition name ICD-10 coding numberDiseasesDatabase

coding number

MedicalSubject

Headings

Leishmania infection *

Malaria infection (Plasmodium infection)

toxoplasmosis

Immune system regulation-related

Immunodeficiency with predominantly antibody defects

Condition name ICD-10 coding numberDiseasesDatabase

coding number

MedicalSubject

Headings

Hereditary hypogammaglobulinemia

Nonfamilial hypogammaglobulinemia

Selective deficiency of immunoglobulin A [IgA]

Selective deficiency of immunoglobulin G [IgG] subclasses

Selective deficiency of immunoglobulin M [IgM]

Immunodeficiency with increased immunoglobulin M [IgM]

Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

Transient hypogammaglobulinemia of infancy

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id=_HFyKIAN2p8C&pg=PA227&lpg=PA227&dq=Hereditary+pyropoikilocytosis&source=vrt&ots=115KXLCnCa&sig=Xgdw21VBHTRInD8CwkTkzWaTdl4&hl=en&ei=gmeiTaejH8OftwepuayQAw&sa=X&oi=book_result&ct=result&resnum=11&ved=0CGMQ6AEwCg#v=onepage&q=Hereditary%20pyropoikilocytosis&f=false) . Wiley-VCH. p. 227.http://books.google.com/books?id=_HFyKIAN2p8C&pg=PA227&lpg=PA227&dq=Hereditary+pyropoikilocytosis&source=vrt&ots=115KXLCnCa&sig=Xgdw21VBHTRInD8CwkTkzWaTdl4&hl=en&ei=gmeiTaejH8OftwepuayQAw&sa=X&oi=book_result&ct=result&resnum=11&ved=0CGMQ6AEwCg#v=onepage&q=Hereditary%20pyropoikilocytosis&f=false. Retrieved 11 April 2011.

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National Library of Medicine). PMC 371766 (http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=371766) . http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=371766.

46. ^ Wilson, William C.; Grande, Christopher M., Hoyt, David B. (2007). "Trauma: Critical Care" (http://books.google.com/books?id=3H3AIEtvc8YC&pg=PA962&lpg=PA962&dq=Hypochromic+anemia+pale+cells&source=bl&ots=p4J4yC2eRe&sig=mhgZnqQ65fbr25e7y2bbt0JD98A&hl=en&ei=T0GVTabbJom90QGotanxCw&sa=X&oi=book_result&ct=result&resnum=7&ved=0CEAQ6AEwBg#v=onepage&q=Hypochromic%20anemia%20pale%20cells&f=false) . Google books. CRC press.p. 962. http://books.google.com/books?id=3H3AIEtvc8YC&pg=PA962&lpg=PA962&dq=Hypochromic+anemia+pale+cells&source=bl&ots=p4J4yC2eRe&sig=mhgZnqQ65fbr25e7y2bbt0JD98A&hl=en&ei=T0GVTabbJom90QGotanxCw&sa=X&oi=book_result&ct=result&resnum=7&ved=0CEAQ6AEwBg#v=onepage&q=Hypochromic%20anemia%20pale%20cells&f=false. Retrieved 1 April 2011.

47. ^ Rivella, S. (May 2009). Ineffective erythropoiesis and thalassemias. National Center for Biotechnology Information, U.S. National Library of Medicine. PMID 19318943(http://www.ncbi.nlm.nih.gov/pubmed/19318943) .

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