Literatur zu Teil 1

Bargmann W (1943) Der Thymus. In: MollendorffW v (Hrsg) Handbuch der mikroskopi­schen Anatomie des Menschen, Bd. 6/IV, S 1-172. Berlin, Springer

Bassius H (1731) Observationes anatomico chirurgico medicae in quatuor decades di­gestae variis observatis rarioribus exornatae et solidis medicae scientiae principiis superstructae, cum figuris aeneis. Halae, Renger

Becker FG (1826) De glandulis thoracis lymphaticis atque thymo. Specimen patholo­gicum. Berolini, A. Hirschwaldium

Blalock A, Mason MF, Morgan HI, Riven SS (1939) Myasthenia gravis and tumors of the thymic region. Report of a case in which the tumor was removed. Ann Surg 110:544--561

Buzzard EF (1905/1906) The clinical history and post-mortem examination of five cases of myasthenia gravis. Brain 28: 438-483

Cappell DF (1934) On lympho-epithelioma of nasopharynx and tonsils. 1 Pathol Bact 39:49-64

Cappell DF (1938) Pathology of nasopharyngeal tumours. 1 Laryngol Otol 53: 558-580 Cooper A (1832) The anatomy of the thymus gland. Longman, Rees, Orme, Green,

and Brown, London Cruveilhier JB (1829) L'anatomie pathologique du corps humain. Livr. 15. Bailliere,

Paris 1829-42 Derigs P (1923) Lymphoepitheliales Carcinom des Rachens mit Metastasen. Virchows

Arch [Pathol Anat] 244: 1-7 Doerr W (1956) Uber lymphoepitheliale Geschwiilste Schmincke-Regaud. Artztl Wo­

chenschr 11: 169-182 Doerr W (1979) Homologiebegriff und pathologische Anatomie. Virchows Arch [Pathol

Anat] 383: 5-29 Dohnert G (1977) Uber lymphoepitheliale Geschwiilste. Erkenntnisse anhand der Gewe­

bekultur und vergleichender klinischer, morphologischer und virologischer Untersu­chungen. Sitzungsberichte der Heidelberger Akademie der Wissenschaften. Springer, Berlin Heidelberg New York

Ebner V v (1902) A. Koelliker's Handbuch der Gewebelehre des Menschen. 6. umgearbei­tete Aufl, 3. Band. Wilhelm Engelmann, Leipzig

Friedleben A (1858) Die Physiologie der Thymusdriise in Gesundheit und Kranheit yom Standpunkte experimenteller Forschung und klinischer Erfahrung. Ein Beitrag zur Lebensgeschichte der Kindheit. Literarische Anstalt [1. Riitten], Frankfurt

Friedmann I, Osborn DA (1966) The nasopharynx. In: Wright GP, Symmers WStC (eds) Systemic Pathology, Vol. I. Longmans, London, Chap 8, pp 309-316

Frisk H (1960) Griechisches etymologisches Worterbuch. Carl Winter, Universitiitsverlag, Heidelberg

Gastpar H, Wilmes E, Wolf H (1981) Epidemiologic, etiologic and immunologic aspects of nasopharyngeal carcinoma [NPC]. 1 Med 12: 257-284

Glisson F (1671) De rhachitide. Lugd. Batav. 1671, pag. 15 [zit. n. Friedleben (1858)] Grundmann E, Krueger GRF, Ablashi DV (eds) (1981) Nasopharyngeal carcinoma.

In: Grundmann E (ed) Cancer Campaign, Vol. 5. Fischer, Stuttgart New York Haller A v (1757-1766) Elementa physiologiae corporis humani. 8 Vols. Bousquet Lau­

sanne Hammar lA (1905) Zur Histogenese und Involution der Thymusdriise. Anat Anz

27:23-30 und 41-89 Hammar lA (1909) Fiinfzig lahre Thymusforschung. Kritische Ubersicht der normalen

Morphologie. Ergeb Anat Entwickl-Gesch 19: 1-274 Hammar lA (1911) Zur groberen Morphologie und Morphogenie der Menschenthymus.

Anat Histol EmbryoI32:201-242 Hammar lA (1926) Die Menschenthymus in Gesundheit und Krankheit. Ergebnisse der

numerischen Analyse von mehr als tausend menschlichen Thymusdriisen. Teil I: Das normale Organ. Zugleich eine kritische Beleuchtung der Lehre des "Status thymicus". Z Mikrosk Anat Forsch 6 [Suppl] 1-570

242 Literatur zu Teill

Hammar JA (1929) Die Menschenthymus in Gesundheit und Krankheit. Ergebnisse der numerischen Analyse von mehr als tausend menschlichen Thymusdriisen. Teil II: Das Organ unter anormalen K6rperverhaltnissen. Zugleich Grundlagen der Theorie der Thymusfunktion. Z Mikrosk Anat Forsch 16 [Suppl] 1-1114

Hammar JA (1936) Die normal-morphologische Thymusforschung im letzten Vierteljahr­hundert. Analyse und Synthese nebst einigen Worten zu der Funktionsfrage. Joh. Ambros. Barth, Leipzig

Hammett FS (1928) Die Physiologie der Thymus. In: Abderhalden E (Hrsg) Fortschritte der naturwissenschaftlichen Forschung. N.F., Heft 4. Urban & Schwarzenberg, Berlin Wien

Hart C (1912) Thymusstudien. II. Die Thymuselemente. Virchows Arch [Pathol Anat] 210:255-277

Hart C (1913) Thymusstudien. III. Die Pathologie der Thymus. Virchows Arch [Pathol Anat] 214: 1-83

Hart C (1915) Thymusstudien. V. Thymusbefunde bei Myasthenia gravis pseudoparaly­tica. Virchows Arch [pathol Anat] 220:185-213

Hartmann A (1914) Neue Untersuchungen iiber den lymphoiden Apparat des Kaninchen­darmes. Anat Anz 47: 65-90

Hassall AH (1846-1849) The microscopic anatomy of the human body, in health and disease. 2 Vois. S. Highley, London - Deutsche Ausgabe: (1851) Arthur Hill Hassall's Mikroskopische Anatomie des menschlichen K6rpers im gesunden und kranken Zu­stande. Aus dem Englischen iibersetzt von Dr. O. Kohlschiitter. Ernst Schafter, Leip­zig

Haugsted FrChr (1812) Thymi in homine ac per seriem animalium Descriptio Anatomica, Pathologica et Physiologica, iconibus XXXIV ad naturam delineatis illustrata. Reitzel, Hafniae

Henle J (1841) Allgemeine Anatomie. L. Voss, Leipzig Henle J (1846) Handbuch der rationellen Pathologie. Friedrich Vieweg u. Sohn, Braun­

schweig Hirsch A (1884-1888) Biographisches Lexikon der hervorragenden Arzte aller Zeiten

und VOlker. 6 Vois. Urban & Schwarzenberg, Wien Leipzig (Reprint Miinchen 1962) His W (1858) Ueber die Thymusdriise. Verh Naturf Ges. Zweiter Theil. Erstes Heft.

523-532 His W (1862) Zur Anatomie der menschlichen Thymusdriise. Z Zooll1: 164 His W (1886) Ueber den Sinus praecervicalis und iiber die Thymusanlage. Arch Anat

Entwickl.-Gesch Anat Abt 421-427 His W (1880-1885) Anatomie menschlicher Embryonen. Vogel, Leipzig Hoppe HH (1892) Ein Beitrag zur Kenntnis der Bulbar-Paralyse. Berl Klin Wochenschr

29:332-336 Hyrtl J (1880) Onomatologia Anatomica. Geschichte und Kritik der anatomischen Spra­

che der Gegenwart. Wilhelm Braumiiller, Wien (Reprografischer Nachdruck: Georg Olms, Hildesheim New York 1970)

Jendrassik AE (1856) Unersuchungen iiber den Bau der Thymusdriise. Sitzungsberichte der Wiener Akademie der Wissenschaften, Math.-Nat. Klasse, Bd. 22

Jolly J (1911) Les organes lympho-epitheliaux. CrAss Anat 13: 164-176 Jolly J (1913) Sur les organes lympho-epitheliaux. C r Soc BioI (Paris) 65: 540-543 Jolly J (1914/15) La bourse de Fabricius et les organes lympho-epitheliaux. Arch Anat

Microsc Morphol Exp 16:363-547 Jolly J (1924) Le thymus et les organes lymphoides. CrAss Anat 19: 167-173 Klose H (1912) Chirurgie der Thymusdriise. In: Bruns P von (Hrsg) Neue Deutsche

Chirurgie, 3. Bd. Ferdinand Enke, Stuttgart Kneringer E, Priesel A (1923) Ein Beitrag zur Kenntnis der Thymome (Lymphoepithe­

lioma thymi). Virchors Arch [pathol Anat] 241: 475-487 K6lliker A (1852) Mikroskopische Anatomie oder Gewebelehre des Menschen. Wilhelm

Engelmann, Leipzig K6lliker A (1861) Entwicklungsgeschichte des Menschen und der h6heren Thiere. Akade­

mische Vortrage. Wilhelm Engelmann, Leipzig

Literatur zu Teil1 243

Kopp IH (1830) Denkwurdigkeiten in der iirztlichen Praxis. 10h. Christ. Hermann'sche Buchhandlung, Frankfurt a. M.

Krueger GRF, Kottaridis SD, Wolf H, Ablashi DV, Sesterhenn K, Bertram G (1981) Histological types of nasopharyngeal carcinoma as compared to EBVserology. Anti­cancer Res 1: 187-194

Laquer L, Weigert C (1901) Beitriige zur Lehre von der Erb'schen Krankheit. I. Ueber die Erb'sche Krankheit (Myasthenia gravis). II. Pathologisch-anatomischer Beitrag zur Erb'schen Krankheit (Myasthenia gravis). Neurol Zentralbl20: 594-601

Leydig F (1852) 1. Beitriige zur mikroskopischen Anatomie und Entwicklung der Rochen und Haie. Wilhelm Engelmann, Leipzig

Leydig F (1857) Lehrbuch der Histologie des Menschen und der Tiere. Meidinger, Sohn u. Co, Frankfurt a.M.

Liddell HG, Scott R (1940) A Greek-English Lexicon. A new edition, revised and augmen­ted throughout by Sir H.St. 10nes. Clarendon Press, Oxford

Lucae SChr (1811) Anatomische Untersuchungen der Thymus in Menschen und Thieren. Heinrich Ludwig Bronner, Frankfurt a.M.

Madri lA, Barwick KW (1982) An immunohistochemical study of nasopharyngeal neo­plasms using keratin antibodies. Epithelial versus nonepithelial neoplasms. Am 1 Surg Pathol6: 143-149

Maximow A (1909) Untersuchungen uber Blut und Bindegewebe. II. tiber die Histogenese der Thymus bei Siiugetieren. Arch Mikroskop Anat 74:525-621

Mayer S (1888) Zur Lehre der Schilddriise und Thymus bei den Amphibien. Anat Anz 3:97-103

Meckel IF (1812) Handbuch der pathologischen Anatomie. Carl Heinrich Rec1am, Leipzig Meckel IF (1815-1820) Handbuch der menschlichen Anatomie, 4 Bd. In den Buchhand­

lungen des Hallischen Waisenhauses, Halle und Berlin Metzger GB (1679) Historia anatomico medica Thymi. 10. Conr. Remmelin, Tubingae Miettinen M, Lehto V-P, Virtanen 1(1982) Nasopharyngeal lymphoepithelioma. Histolo­

gical diagnosis as aided by immunohistochemical demonstration of keratin. Virchows Arch [Cell Pathol] 40: 163-169

Miloslavich E (1912) Ein weiterer Beitrag zur pathologischen Anatomie der militiirischen Selbstmorder. Virchows Arch [Pathol Anat] 208:44-53

Mollier S (1913) Die Iymphoepithelialen Organe. Sitzgsber Ges Morph u Physiol Mun­chen. 29:14-37

Morton LT (1970) A medical bibliography (Garrison and Morton). An annotated check­list of texts illustrating the history of Medicine. 3rd ed. Grafton Book, Andre Deutsch, Edinburgh

Muir CS (1967) Nasopharyngeal cancer - a historical vignette. In: Muir CS, Shanmuga­ratnam K (eds) Cancer of the nasopharynx. UICC Monograph Series, Vol. 1. Munks­gaard, Copenhagen, pp 13-17

Muir CS, Shanmugaratnam K (eds) (1967) Cancer of the nasopharynx. UICC Mono­graph Series, Vol. 1. Munksgaard, Copenhagen

Muller 1 (1830) De glandularum secernentium structura pentiori. L. Vossii, Lipsiae New GB, Kirch W (1928) Tumors of nose and throat: A review of literature. Arch

Otolaryngol 8: 600-607 Paltauf A (1889) Ueber die Beziehungen der Thymus zum plotzlichen Tod. Wien Klin

Wochenschr 2: 877-881 Paltauf A (1890) Ueber die Beziehungen der Thymus zum plotzlichen Tod. Wien Klin

Wochenschr 3:172-175 Passow F (1970) Handworterbuch der griechischen Sprache. Wissenschaftliche Buchge­

sellschaft, Darmstadt Platter F (1614) Observationum in hominis affectibus. L. Konig, Basileae Portriit 2. Der Arzt. Graphische Bildnisse des 16.-20. larhunderts aus dem Portriitarchiv

Diepenbroick. Landschaftsverband Westfalen-Lippe, Westfiilisches Landesmuseum fUr Kunst und Kulturgeschichte. Ausstellungskatalog 1979

Prenant A (1893) Recherches sur Ie developpement organique et histologique des derives branchiaux. I. Thymus. Compt rend hebdom Soc Bioi 9: 5

244 Literatur zu Teil 2

Prenant A (1894) Contribution a l'etude organique et histologique du thymus, de la glande thyroide et de la glande carotidienne. La Cellule 10

Quick D, Cutler M (1927) Transitional cell epidermoid carcinoma. Surg Gynec Obstet 45:320-331

Regaud C (1921) Diskussionsbemerkung zu Reverchon und Coutard Remak R (1855) Untersuchungen tiber die Entwicklung der Wirbelthiere. G. Reimer,

Berlin Reverchon L, Coutard H (1921) Lymphoepitheliome de l'hypopharynx traite par Ie roent­

gentherapie. Bull Soc Fran~ Oto-Rhino-Lar 34:209-214 Schmincke A (1921) Uber lymphoepitheliale Geschwiilste. Beitr. Pathol Anat 68: 161-169 Schmincke A (1926) Pathologie des Thymus. In: Henke F, Lubarsch 0 (Hrsg) Drusen

mit innerer Sekretion. Springer, Berlin. (Handbuch der speziellen pathologichen Ana­tomie und Histologie, Achter Band, S 760-809)

Schumacher Roth (1913) Thymektomie bei einem Fall von Morbus Basedowi mit Myas­thenie. Mitteil Grenzgeb Med Chir 25:746-765

Shanmugaratnam K, Sobin LH (1978) Histological typing of upper respiratory tract tumours. International Histological Classification of Tumours, No. 19. World Health Organization, Geneva

Shanmugaratnam K, Chan SH, The G de, Goh JFH, Khor TH, Simons MJ, Tye CY (1979) Histopathology of nasopharyngeal carcinoma. Correlations with epidemiology, survival rates and other biological characteristics. Cancer 44: 1029-1044

Simon J (1845) A physiological essay on the thymus gland. Henry Renshaw, Strand, London

Sobotta J (1914) Die Thymusdruse (Glandula thymus). In: Bardeleben K v (Hrsg) Hand­buch der Anatomie des Menschen. 6. Bd, 3. Abteilung, 3. Teil. Fischer, Jena

Stieda L (1881) Untersuchungen tiber die Entwicklung der Glandula thymus, Glandula thyreoidea und Glandula carotica. Wilhelm Engelmann, Leipzig

Tesseraux H (1959) Physiologie und Pathologie des Thymus. In: Zwanglose Abhand­lungen aus dem Gebiet der inneren Sekretion, Bd. 9. Joh. Ambros. Barth, Leipzig

Toldt C (1877) Lehrbuch der Gewebelehre. Ferdinand Enke, Stuttgart Verhandlungen der Deutschen Gesellschaft fUr Pathologie. 65. Tagung (Dhom, G Hrsg).

Fischer, Stuttgart New York Watney H (1878) Note on the minute anatomy of the thymus. Proc Roy Soc (London)

27:369-370 Watney H (1881) Further note on the minute anatomy of the thymus. Proc Roy Soc

(London) 31: 326-327 Watney H (1882) The minute anatomy of the thymus. Proc Roy Soc (London) 33: 349-352 Watney H (1883) The minute anatomy of the thymus. Philosoph. Transactions of the

Royal Society of London 173, Part III: 1063-1123 Wolf H (1981) Die Verwendung verschiedener Nukleinsiiure-Hybridisierungstechniken

am Beispiel von Epstein-Barr-Virus korrelierter Erkrankungen. Verh Dtsch Ges Pa­thoI65:47-57

Wolf H, Bayliss GJ, Wilmes E (1981) Biological properties of Epstein-Barr virus. In: Grundmann E, Krueger GRF, Ablashi DV (eds) Nasopharyngeal Carcinoma. In: Grundmann E (ed) Cancer Campaign, Vol. 5, Fischer, Stuttgart New York, p 101-109

Yeh S (1962) A histological classification of carcinomas of the nasopharynx with a critical review as to the existence oflymphoepitheliomas. Cancer 15:895-920

Literatur ZU Teil2

Entwicklungsgeschichte

Alteniihr E (1981) Nebenschilddrusen. In: Doerr W, Seifert G (Hrsg) Spezielle pathologi­sche Anatomie, Bd. 14/I. Springer, Berlin Heidelberg New York, S 417-521

Bargmann W (1943) Der Thymus. In: MollendorffW v (Hrsg) Handbuch der mikroskopi­schen Anatomie des Menschen, Bd. 6/IV. Springer, Berlin, S 1-172

Entwicklungsgeschichte 245

Bryant BJ (1971) Lymphoproliferative cycles in the thymus cortex. J Immunol 107: 1791-1794

Cordier AC (1974) Ultrastructure of the thymus in "nude" mice. J Ultrastruct Res 47:26--40

Cordier AC (1975) Ultrastructure of the cilia of thymic cysts in "nude" mice. Anat Rec 181 :227-250

Cordier AC, Haumont StM (1980) Development of thymus, parathyroids, and ultimo­branchial bodies in NMRI and nude mice. Am J Anat 157:227-263

Cordier AC, Heremans JF (1975) Nude mouse embroy: Ectodermal nature of the primor­dial thymic defect. Scand J Immunol 4: 193-196

Crisan C (1935) Die Entwicklung des thyreo-parathyreo-thymischen Systems der weiBen Maus. Z Anat Entwikl-Gesch 104: 327-358

Dearth OA (1928) Late development of the thymus in the cat: Nature and significance of the corpuscles of Hassall and cystic formations. Am J Anat 41: 321-352

Ebner Vv (1902) Von der Thymus. In: A. Koelliker's Handbuch der Gewebelehre des Menchen. 6. Aufl. Bd. III, Wilhelm Engelmann, Leipzig, S 328-340

Ford CE, Micklein HS, Evans EP (1966) The inflow of bone marrow cells to the thymus. Studies with part body irradiated mice infected with chromosome marked bone mar­row and subjected to antigenic stimulation. Ann NY Acad Sci 129: 283-296

Frazier JA (1973) Ultrastructure of the chick thymus. Z Zellforsch 136: 191-205 Gatien JG, Schneeberger EE, Merler E (1975) Analysis of human thymocyte subpopula­

tions using discontinuous gradients of albumin: Precursor lymphocytes in human thymus. Eur J ImmunoI5:312-317

Gaudecker B v, Miiller-Hermelink HK (1980) Ontogeny and organization of the statio­nary non-lymphoid cells in the human thymus. Cell Tissue Res 207:287-306

Gilmour JR (1937) The embryology of the parathyroid glands, the thymus and certain associated rudiments. J Pathol Bact 45: 502-522

GroschuffK (1900) Uber das Vorkommen eines Thymussegmentes der vierten Kiementa­sche beim Menschen. Anat Anz 17: 161-170

Groscurth P, Kistler G (1975a) Histogenese des Immunsystems der "nude" Maus. I. Priinatale Entwicklung des Thymus: eine lichtmikroskopische Studie. Beitr Pathol 154:109-124

Groscurth P, Kistler G (1975b) Histogenese des Immunsystems der "nude" Maus. IV. Ultrastruktur der Thymusanlage 12- und 13tiigiger Embryonen. Beitr. Pathol 156:359-375

Groscurth P, Miintener M, Tondury G (1975) Histogenese des Immunsystems der "nude" Maus. II. Postnatale Entwicklung des Thymus: eine lichtmikroskopische Studie. Beitr PathoI154:125-139

Haar JL (1974) Light and electron microscopy of the human fetal thymus. Anat Rec 179:463-476

Hammar JA (1905) Zur Histogenese und Involution der Thymusdriise. Anat Anz 27:23-30 und 41-89

Hammar JA (1909) Fiinfzig Jahre Thymusforschung. Kritische Ubersicht der normalen Morphologie. Ergeb Anat Entwickl-Gesch 19: 1-274

Hammar JA (1911 a) Zur Kenntnis der Elasmobranchierthymus. Zool Jb Anat u Ontog 32:135-180

Hammar JA (1911 b) Zur groberen Morphologie und Morphogenie der Menschenthymus. Anat Histol Embryol43 :201-242

Hayward AR, Ezer G (1974) Development of lymphocyte popUlations in the human foetal thymus and spleen. Clin Exp Immunol 97: 169-178

Hemmingsson EJ, Aim GV (1973) Migration of haemopoietic cells from the yolk sac to the thymus and the bursa of Fabricius in the chick embryo. Acta Pathol Microbiol Scand [A] 81 :79-84

Hess MW (1970) Lymphatischer Apparat, insbesondere Thymus, in der Pathogenese der Defektimmunopathien. In: Studer A, Cottier H (Hrsg) Immunreaktionen. Sprin­ger, Berlin Heidelberg New York (Handbuch der allgemeinen Pathologie, Bd. Vllj3. S 182-236)

246 Literatur zu Teil 2

Hirokawa K (1969) Electron microscopic observation of the human thymus of the fetus and the newborn. Acta Pathol Jpn 19: 1-13

Hirokawa K, Hatakeyama S (1969) Immuno-cytochemical study on the development and differentiation of the immune system of the human fetus. Acta Pathol Jpn 19:151-160

His W (1886) Uber den Sinus praecervicalis und iiber die Thymusanlage. Arch Anat Entwickl-Gesch, Anat Abt 421-427

Hoshino T, Takeda M, Abe K, Ito T (1969) Early development of thymic lymphocytes in mice, studied by light and electron microscopy. Anat Rec 164:47-66

Jedlicka V (1928) Sur la persistance chez I'homme de restes du metamere thymique IV dans la vie postfoetale. Rev Frany Endocrin 6: 122-148

Kay HEM, Doe J, Hockley A (1970) Response of human foetal thymocytes to phythae­magglutinin (PHA). Immunology 18: 393-396

Kendall MD (1980) Avian thymus glands: A review. Develop Comp Immunol4: 191-210 Kolliker A (1852) Mikroskopische Anatomie oder Gewebelehre des Menschen. Zweiter

Band: Spezielle Gewebelehre. Zweite Halfte. 1. Abtheilung, Wilhelm Engelmann, Leipzig, S 333-346

Kolliker A (1869) Entwicklungsgeschichte des Menschen und der hoheren Thiere. Akade­mische Vortrage, 1. Auflage, Wilhelm Engelmann, Leipzig, 2. Aufl. 1879

Kostowiecki M (1967) Secretory component in the thymus on the pregnant white rats. Z Mikrosk Anat Forsch 76:141-183

Krech WG, Storey CF, Umiker WC (1954) Thymic cysts. Review of the literature and report of two cases. J Thorac Surg 27: 477-493

LeDouarin NM, Jotereau FV (1975) Tracing of cells of the avian thymus through embryo­nic life in interspecific chimera. J Exp Med 142: 17-40

Moore MAS, Owen JJT (1967) Experimental studies on the development of the thymus. J Exp Med 126:715-725

Norris EH (1938) The morphogenesis and histogenesis of the thymus gland in man: In which the origin of the Hassall's corpuscles of the human thymus is discovered. Carnegie Inst. Wsh. Pub!. no. 496. Contrib Embryol27:191-221

Owen JJT (1970) Ontogenesis of immunobiological systems. In: Studer A, Cottier H (Hrsg) Immunreaktionen. Springer, Berlin Heidelberg New York (Handbuch der all­gemeinen Pathologie, Bd. VII/3, S 129-181)

Owen JJT, Ritter MA (1969) Tissue interaction in the development of thymus lymphocy­tes. J Exp Med 129 :431-442

Papiernik M (1972) Ontogeny of the human lymphoid system: Study of the cytological maturation and the incorporation of tritiated thymidine and uridine in the foetal thymus and lymph node and in the infantile thymus. J Cell Physiol 80: 235-242

Pearse AGE (1977) Das diffuse endokrine (parakrine) System: Feyrter's Konzept und seine moderne Geschichte. Verh Dtsch Ges Pathol61 :2-6

Pinkel D (1968) Ultrastructure of human fetal thymus. Am J Dis Child 115:222-238 Politzer G, Hann F (1935) Uber die Entwicklung der branchiogenen Organe beim

Menschen. Z Anat 104:670-708 Ropke C, Deurs B van, H0yer PE (1977) DNA-synthesizing cells in human fetal thymus.

Cell Tissue Res 178: 333-339 Schambacher A (1903) Uber die Persistenz von Driisenkanalen in der Thymus und ihre

Beziehung zur Entstehung der Hassallschen Korperchen. Virchows Arch [Pathol Anat]172 : 368-394

Shier KJ (1963) The morphology of the epithelial thymus. Observations on Iymphocyte­depleted and fetal thymus. Lab Invest 12:316-326

Shier KJ (1981) The thymus according to Schambacher: Medullary ducts and reticular epithelium of thymus and thymomas. Cancer 48: 1183-1199

Sobotta J (1914) Anatomie der Thymusdriise (Glandula thymus). In: Bardeleben K v (Hrsg) Handbuch der Anatomie des Menschen, Bd. V1/3. Dritter Teil. Gustv Fischer, Jena, S 103-154

Tesseraux H (1959) Physiologie und Pathologie des Thymus. In: Zwanglose Abhand­lungen aus dem Gebiet der inneren Sekretion, Bd. 9. Joh. Ambr. Barth, Leipzig

Fehlbildungen 247

Weller GL (1933) Development of the thyroid, parathyroid, and thymus glands in man. Carnegie Inst Wsh Publ no 443. Contrib EmbryoI24:93-143

Wiesel J (1912) Pathologie des Thymus. In: Lubarsch 0, Ostertag R (Hrsg) Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie des Menschen und der Tiere. xv. Jahrgang. II. Abteilung. J.F. Bergmann, Wiesbaden, S 416-782

Wright RK (1976) Phylogenetic origin of the vertebrate lymphocyte and lymphoid tissue. In: Wright RK, Cooper EL (eds) Phylogeny of thymus and bone marrow-bursa cells. North-Holland Publ, Amsterdam New York Oxford, p 57-70

Zimmermann A, Brun del Re G, Biirki H, Keller HU, Hess MW, Cottier H (1975) Lymphozytenformen. Morphologische und funktionelle Charakterisierungsmog­lichkeiten, Herkunft und Entwicklung. In: Theml H, Begemann H (Hrsg) Lymphozyt und klinische Immunologie. Physiologie-Pathologie-Therapie. Springer, Berlin Heidel­berg New York, S 2-15

Fehlbildungen

Altenahr E (1981) Nebenschilddriisen. In: Doerr W, Seifert G (Hrsg) Spezielle pathologi­sche Anatomie, Bd. 14/1, Springer, Berlin Heidelberg New York, S 417-521

Arnheim EE, Gemson BL (1950) Persistent cervical thymus gland, thymectomy. Surgery 27:603-608

Bay V (Hrsg) (1969) Der autonome und regulative Hyperparathyreoidismus in patholo­gisch-anatomischer, interner und chirurgischer Sicht. Enke, Stuttgart

Bhaskar SN, Bernier JL (1959) Histogenesis of branchial cysts. A report of 468 cases. Am J Pathol 35: 407-423

Dietel M (1982) Person!' Mitteilung Dustin AP, Gerard P (1921) Sur I-existence des rapports de continuite directe entre

parathyroides, thyroide et nodules thymiques chez les mammiferes. C r Soc BioI (Paris) 85: 876-877

Dyke JH van (1941) On the origin of accessory thymus tissue, thymus IV. The occurence in man. Anat Rec 79: 179-204

Dyke JH van (1945) Behavior of ultimobrancial tissue in the postnatal tyroid gland: Epithelial cysts, their relation to thyroid parenchyma and to "new-growths" in the thyroid gland of young sheep. Am J Anat 76:201-251

Dyke JH van (1952) Origin of accessory tyroid tissue from thymus IV in adult baboon. Arch Pathol 54: 248-258

Dyke JH van (1953) Experimental aberrant mediastinal goiters (thymic) in the rat. Arch PathoI55:412-422

Erdheim J (1904) I. Uber Schilddriisenaplasie. II. Geschwiilste des Ductus thyreoglossus. III. Uber einige menschliche Kiemendarmderivate. Beitr Pathol Anat AUg Pathol 35:366-433

Freeman JB, Sherman BM, Mason EE (1976) Transcervical thymectomy: An integral part of neck exploration for hyperparathyroidism. Arch Surg 111 :359-364

Gilmour JR (1937) The embryology of the parathyroid glands, the thymus and certain associated rudiments. J Pathol Bact 45:502-522

GroschuffK (1900) Uber das Vorkommen eines Thymussegmentes der vierten Kiementa­sche beim Menschen. Anat Anz 17: 161-170

Gruber GB (1920) Uber Variationen der Thymusform und -lage. Z Angew Anat 6:320-332

Gruber GB (1932) Die Entwicklungsstorungen der Thymusdriise. In: Schwalbe E, Gruber GB (Hrsg) Die Morphologie der Missbildungen des Menschen und der Tiere. III. Teil: Die Einzelmissbildungen. XV. Lieferung, 3. Abteilung. Fischer, Jena, S 710-757

Hagens EW (1932) Malformation of the auditory apparatus in the newborn associated with ectopic thymus. Arch OtolaryngoI15:671-680

Hammar JA (1936) Die normal-morphologische Thymusforschung im letzten Vierteljahr­hundert. Analyse und Synthese nebst einigen Worten zu der Funktionsfrage. Joh. Ambr. Barth, Leipzig

248 Literatur zu Teil 2

Kurtay M, Crile G (1969) Aberrant parathyroid glands in relationship to the thymus. Am J Surg 117:705

Laage-Hellman JE (1952) Accessory thymus tissue of the neck. Acta Otolaryngol (Stockh) 42:375-378

Lewis MR (1962) Persistance of the thymus in the cervical area. J Pediatr 61: 887-893 Maruta M, Yoshino K, Mimura T, Yoshimatsu H, Oekusa M (1972) A case of intra thy­

mic parathyroid adenoma with hyperparathyroidism. Keio J Med 21: 181-188 Nathaniels EK, Nathaniels AM, Wang Ch-A (1970) Mediastinal parathyroid tumors:

A clinical and pathological study of 84 cases. Ann Surg 171: 165-170 Norris EH (1938) The morphogenesis and histogenesis of the thymus gland in man:

In which the origin of the Hassall's corpuscles of the human thymus is discovered. Carnegie Inst. Wsh. Publ. no. 496. Contrib EmbryoI27:191-221

Politzer G, Hann F (1935) Uber die Entwicklung der branchiogenen Organe beim Menschen. Z Anat 104:670-708

Ridenhour CE, Henzel JH, DeWeese MS, Earl Kerr S (1970) Thymoma arising from undescended cervical thymus. Surgery 67:614-619

Rosai J, Levine GD (1976) Tumors of the thymus. In: Atlas of Tumor Pathology. Sec. Ser., Fasc. 13. Armed Forces Institute of Pathology, Wshington, DC

Rothmund M (1980) Therapie des primiiren Hyperparathyreoidismus. In: Rothmund M (Hrsg) Hyperparathyreoidismus. Thieme, Stuttgart New York, S 161-200

Schmincke A (1926) Pathologie des Thymus. In: Henke F, Lubarsch 0 (Hrsg) Handbuch der speziellen pathologischen Anatomie und Histologie. Bd. 8. S. 760-809. Springer, Berlin

Tesseraux H (1959) Physiologie und Pathologie des Thymus. In: Zwanglose Abhand­lungen aus dem Gebiet der inneren Sekretion, Bd. 9. Joh. Ambr. Barth, Leipzig

Tsuchiya M, Kamegaya K, Shimabukuro K, Takagi K, Yoshimatsu H (1971) Intrathymic parathyroid tissue in man: Clinical significance and report of a case of intrathymic parathyroid adenoma. Keio J Med 20:91-102

Wadon A (1934) Thymoma intratracheale. Zentralbl Allg PathoI60:308-312 Wang Ch-A (1971) Surgery of the parathyroid glands. Adv Surg 5: 109-127 Wang Ch-A (1976) The anatomic basis of parathyroid surgery. Ann Surg 183:271-275 Weller GL (1933) Development of the thyroid, parathyroid, an thymus glands in man.

Carnegie Inst. Wash. Publ. no. 443. Contrib EmbryoI24:93-143

Topographie, makroskopisch~ Anatomie, Histologie

Abbot A, Burnet FM (1964) Electron microscopy of the thymus leions in NZB mice. J Pathol Bact 88:243-245

Abe K, Ito T (1970) Fine structure of small lymphocytes in the thymus of the mouse: Qualitative and quantitative analysis by electron microscopy. Z Zellforsch Mikrosk Anat 110:321-335

Abraham R, Morris M, Hendy R (1969) Lysosomal changes in epithelial cells of the mouse thymus after hydrocortisone treatment. Histochemie 17:295-311

Asma GEM, Pichler W, Schuit HRE, Knapp W, Hijmans W (1977) The development of lymphocytes with T - or B-membrane determinants in the human foetus. Clin Exp ImmunoI29:278-285

Aubertin Ch, Bordet E (1909) Uber die Einwirkung der X-Strahlen auf die Thymus. Zentralbl Inn Med 40: 977-989

Baak JPA, Kater L (1975) The central thymus area. A hitherto undescribed region in the Guinea-pig thymus. BioI Med Sci 78: 123-129

Baak JP A, Meijer ChJLM, Nieuwenhuyzen Kruseman AC, Langevoort HL, Kater L (1976) B lymphocytes in the Guinea pig thymus are specifically localized in the central area.JImmunoI117:463-466

Baak JPA, Meijer ChJLM, Scheper RJ, Mullink R, Kater L (1978) Production and traffic of B-Iymphocytes in the extracortical central area of the Guinea pig thymus. Int Archs Allergy Appl ImmunoI56:423-434

Topographie, makroskopische Anatomie, Histologie 249

Balfour BM, Drexhage HA, Kamperdijk EWA, Hoefsmit EChM (1981) Antigen-presen­ting cells, including Langerhans cells, veiled cells and interdigitating cells. In: Micro­environments in haemopoietic and lymphoid differentiation. Ciba Foundation Sympo­sium 84. Pitman, London, pp 281-301

Bargmann W (1943) Der Thymus. In: MollendorffW v (Hrsg) Handbuch der mikroskopi­schen Anatomie des Menchen, Bd. 6jIV. Springer, Berlin, S 1-172

Bearman RM, Bensch KG, Levine GD (1975) The normal thymic vasculature: An ultra­structural study. Anat Rec 183:485-498

Bearman RM, Levine GD, Bensch KG (1978) The ultrastructure of he normal human thymus: A study of 36 cases. Anat Rec 190: 755-782

Betel I, Mathieson BJ, Sharrow SO, Asofsky R (1980) Distribution of Lyt phenotypes in thymocyte subpopulations as measured by flow microfluorometry: Selective enrich­ment ofLyt 1 +2r thymocytes. J ImmunoI124:2209-2217

Bhathal PS, Campbell PE (1965) Eosinophil leucocytes in the child's thymus. Austr NZJ Med 14:210-213

Blau IN (1967a) The dynamic behaviour of Hassall's corpuscles and the transport of particulate matter in the thymus of the guinea pig. Immunology 13: 281-292

Blau IN (1967b) Antigen and antibody localisation in Hassall's corpuscles. Nature 215:1073-1075

Blau IN (1973) Hassall's corpuscles - a site of thymocyte death. Brit J Exp Pathol 54:634-637

Blau IN, Jones RN, Kennedy LA (1968) Hassall's corpuscles: A measure of activity in the thymus during involution and reconsitution. Immunology 15:561-570

Bloodworth JMB, Hiratsuka H, Hickey RC, Wu J (1975) Ultrastructure of the human thymus, thymic tumors, and myasthenia gravis. Pathol Annu 10:329-391

Bradfield JW (1973) Altered venules in the stimulated human thymus as evidence of lymphocyte recirculation. Clin Exp ImmunoI13:243-252

Bradstock KF, Janossy G, Pizzolo G, Hoffbrand AV, McMichael A, Pilch JR, Milstein C, Beverley P, Bollum FJ (1980) Subpopulations of normal and leukemic human thymocytes: An analysis with the use of monoclonal antibodies. J Natl Cancer Inst 65:33-42

Brent L, Davies AJS (1975) Die Regulation des lymphatischen Systems. In: Theml H, Begemann H (Hrsg) Lymphozyt und klinische Immunologie. Physiologie-Pathologie­Therapie. Springer, Berlin Heidelberg New York, S 41-49

Buerki H, Massner B, Cottier H, Chanana AD, Foel DD, Cronkite EP (1977) Lymphope­nia and lymph node histology following repetitive extracorporeal irradiation of blood in normal and thymectomized calves. Beitr Pathol 160: 38-49

Burnet FM (1965) Mast cells in the thymus ofNZB mice. J Pathol Bact 89:271-284 Burnet FM (1966) Mast cells in the mouse thymus. In: Wolstenholme GEW, Porter

R (eds) The Thymus: Experimental and clinical studies. Ciba Foundation Symposium. J. & A. Churchill, Ldt, London, pp 335-340

Burnet FM (1969) Cellular immunology. Books one and two. University Press, Melbourne and Cambridge

Burnet FM, Holmes MC (1964) Thymic changes in the mouse strain NZB in relation to the auto-immune state. J Pathol Bact 88:229-241

Cantor H, Boyse EA (1977a) Lymphocytes as models for the study of mammalian cellular differentiation. Immunol Rev 33: 105-124

Cantor H, Boyse EA (1977b) Regulation of cellular and humoral immune responses by T cell subclasses. Cold Spring Harbor Symp Quant BioI 41 : 23-32

Cantor H, Weissmann I (1976) Development and function of sub populations ofthymocy­tes and T lymphocytes. Prog Allergy 20: 1-64

Chapman WL, Allen JR (1971) The fine structure of the thymus of the fetal and neonatal monkey (Macaca mulatta). Z Zellforsch 114:220-223

Charipper HA, Mayes HE (1946) The time of occurrence and method for formation of the thymic corpuscles in the albino rat. Anat Rec 96: 569

Ciaccio C (1906) Ricerche istologiche e citologiche suI timo degli Uccelli. Anat Anz 29:597-600

250 Literatur zu Teil2

Ciaccio C (1942) Contributo all'istochimica delle cellule enterocromaffini. II. Cellule cromaffini del timo di Gallus domesticus. Boll Soc Ital BioI Sper 17: 619-620

Clark SL (1963) The thymus in mice of strain 129/J, studied with the electron microscope. Am J Anat 112: 1-33

Clark SL (1966) Cytological evidences of secretion in the thymus. In: Wolstenholme GEW, Porter R (eds) The Thymus: Experimental and clinical studies. Ciba Founda­tion Symposium. J. & A. Churchill Ltd, London, pp 3-30

Clark SL (1968) Incorporation of sulfate by the mouse thymus: Its relation to secretion by medullary epithelial cells and to thymic lymphopoiesis. J Exp Med 128: 927-958

Clark SL (1973) The intrathymic environment. In: Davies AJS, Carter RL (eds) Thymus Dependency. Contemp. Topics Immunobiol. Vol. II. Plenum Press, New York Lon­don, pp 77-79

Cordier AC (1974) Ultrastructure of the thymus in "nude" mice. J Ultrastruct Res 47:26-40

Cordier AC (1975) Ultrastructure of the cilia of thymic cysts in "nude" mice. Anat Rec 181 :227-250

Cottier H (1980) Pathogenese. Bd. 2. Springer, Berlin Heidelberg New York Cowan WJ, Sorenson GD (1964) Electron microscopic observations of acute thymic

involution produced by hydrocortisone. Lab Invest 13: 353-370 Cremieu R (1912) Etude des effets produits sur Ie thymus par les rayons X. Recherches

experimentales. Deductions histo-physiologiques. Applications therapeutiques. These de Lyon

Curtis SK, Volpe EP, Cowden RR (1972) Ultrastructure of the developing thymus of the leopard frog (Rana pipiens). Z Zellforsch 127:323-346

Deanesly R (1929) Experimental studies on the histology of the mammalian thymus. Quart J Micr Sci 72:247-275

Djaczenko W, Garaci E (1976) Dark reticular epithelial cells of the thymus as the primary target of heterologous anti-lymphocyte serum in BALB/c mice. An ultrastructural study correlated with data on thymus substitution. Clin Immunol Immunopathol 6:213-230

Dourov N (1974) Study of the cytoplasmic lipids in thymic involution. Pathol Europ 9:43-57

Drenckhahn D, Unsicker K, Griesser GH, Schumacher U, Gr6schel-Stewart U (1978) Different myosins in myoid and entodermal reticular epithelial cells of the thymus. An immunocytochemical study using specific antibodies against striated and smooth muscle myosin. Cell Tiss Res 187:97-103

Drenckhahn D, Gaudecker B v, Miiller-Hermelink HK, Un sicker K, Gr6schel-Stewart U (1979) Myosin and actin containing cells in the human postnatal thymus. Ultra­structural and immunohistochemical findings in normal thymus and in myasthenia gravis. Virchows Arch [Cell Pathol] 32: 33--45

Dung HC (1973) Electron microscopic study of involuting thymus of "lethargic" mutant mice. Anat Rec 177: 585-601

Dustin AP (1909) Contribution a l'etude du thymus des reptiles. Arch Zool Exp Gen 2:43-227

Engel WK, Trotter JI, McFarlin DE, McIntosh CI (1977I) Thymic epithelial cells contains acetylcholine receptor. Lancet 1310-1311

Ewijk W v, Soest PL v, Engh GJ v d (1981) Fluorescence analysis and anatomic distribu­tion of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200. J ImmunoI127:2594-2604

Feltkamp-Vroom T (19661) Myoid cells in human thymus. Lancet 1320-1321 Fennell RA, Pearse AGE (1961) Some histochemical observations on the bursa of Fabri­

cius and thymus of the chicken. Anat Rec 139: 93-104 Franke WW, Schiller DL, Moll R, Winter S, Schmid E, Engelbrecht I, Denk H, Krepler

R, Platzer B (1981) Diversity of Cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J Mol BioI 153: 933-959

Frazier JA (1973) Ultrastructure of the chick thymus. Z Zellforsch 135: 191-205

Topographie, makroskopische Anatomie, Histologie 251

Furth R v, Cohn ZA, Hirsch JG, Humphrey JH, Spector WG, Langevoort HL (1972) The mononuclear phagocyte system: A new classification of macrophages, monocytes, and their precursor cells. Bull WHO 46:845-852

Furth Rv, Langevoort HL, Schaberg A (1975) Mononuclear phagocytes in human pathol­ogy, proposal for an approach to improved classification. In: Furth R v (ed) Mono­nuclear Phagocytes in Immunity, Infection and Pathology. Blackwell Scientific Publi­cations, Oxford, pp 1-15

Gad P, Clark SL (1968) Involution and regeneration of the thymus in mice, induced by bacterial endotoxin and studied by quantitative histology and electron microscopy. Am J Anat 122:573-606

Garaci E, Pecci G, Rinaldi-Garaci C, DelGobbo V, Tonietti G (1978) Ultrastructural and functional changes of the mouse thymus following treatment with an antiserum specific for thymic epithelial cells. Clin Immunol Immunopathol 11 : 157-167

Gaudecker B v (1977) Die fortschreitende Erweiterung mesodermaler perivascuHirer Raume im Thymus des Menschen. Verh Anat Ges 71 :783-787

Gaudecker B v (1978) Ultrastructure of the age-involuted adult human thymus. Cell Tissue Res 186: 507-525

Gaudecker B v, Hinrichsen K (1965) Elektronenmikroskopische Untersuchungen zur Cytologie von Thymusrinde und Keimzentrum. Z Zellforsch 65: 139-162

Gaudecker B v, Miiller-Hermelink HK (1979) Ontogenetic differentiation of epithelial and non-epithelial cells in the human thymus. Adv Exp Med Bioi 114: 19-23

Gaudecker B v, Miiller-Hermelink HK (1980) Ontogeny and organization of the statio­nary non-lymphoid cells in the human thymus. Cell Tissue Res 207:287-306

Gaudecker B v, Schmale EM (1974) Similarities between Hassall's corpuscles of the human thymus and the epidermis. An investigation by electron microscopy and histo­chemistry. Cell Tissue Res 151 :347-368

Gervaso MV (1969) Contributo alla conoscenza delle cellule enterocromaffini e pre­enterocormaffini argentofile nel timo dei rettili. Riv Istochim Norm Pathol 15: 20-23

Gilmore RStC, Bridges JB (1974) Histological and ultrastructural studies on the myoid cells of the thymus of the domestic fowl (Gallus domesticus). J Anat 118:409-416

Gilmour JR (1937) The embryology of the parathyroid glands, the thymus and certain associated rudiments. J Pathol Bact 45: 502-522

Ginsburg H, Sachs L (1963) Formation of pure suspensions of mast cells in tissue culture by differentiation of lymphoid cells from the mouse thymus. J Natl Cancer Inst 31:1--40

Gitlin D, Landing BH, Whipple A (1953) The localization of homologous plasmaproteins in the tissue of young human beings as demonstrated with fluorescent antibodies. J Exp Med 97:163-176

Goldstein G, Abbot A, Mackay IR (1968) An electron-microscope study of the human thymus: Normal appearances and findings in myasthenia gravis and systemic lupus erythematosus. J Pathol Bact 95:211-215

Gorgoll6n P, Ottone-Anaya M (1978) Fine structure of canine thymus. Acta Anat (Basel) 100: 136-152

Groscurth P (1980a) Non-lymphatic cells in the lymph node cortex of the mouse. I. Morphology and distribution of the interdigitating cells and the dendritic reticular cells in the mesenteric lymph node of the adult ICR mouse. Pathol Res Pract 169:212-234

Groscurth P (1980b) Non-lymphatic cells in the lymph node cortex of the mouse. II. Postnatal development of the interdigitating cells and the dendritic reticular cells. Pathol Res Pract 169:235-254

Groscurth P (1980c) Non-lymphatic cells in the lymph node cortex of the mouse. III. Interdigitating cells and dendritic reticular cells in the mesenteric lymph node of the homozygous "nude" (nu/nu) mouse. Pathol Res Pract 169:255-268

Haar JL (1974) Light and electron microscopy of the human fetal thymus. Anat Rec 179:463--476

Haelst UJG v (1967a) Light and electron microscopic study of the normal and pathologi­cal thymus of the rat. I. The normal thymus. Z Zellforsch 77: 534--553

252 Literatur zu Teil2

Haelst UJG v (1967b) Light and electron microscopic study of the normal and pathologi­cal thymus of the rat. II. The acute thymic involution. Z Zellforsch 80: 153-182

Haelst UJG v (1969) Light and electron microscopic study of the normal and pathological thymus of the rat. IlL A mesenchymal histiocytic type of cell. Z Zellforsch 99: 198-209

Hakanson R, Larsson L-I, Sundler F (1974) Peptide and amine producing endocrine-like cells in the chicken thymus. A chemical, histochemical and electron microscopic study. Histochemistry 39: 25-34

Hammar JA (1905) Zur Histogenese und Involution der Thymusdriise. Anat Anz 27:23-30 und 41-89

Hammar JA (1909) Fiinfzig Jahre Thymusforschung. Kritische Ubersicht der normalen Morphologie. Ergeb Anat Entwickl.-Gesch 19: 1-274

Hammar JA (1911) Zur graberen Morphologie und Morphogenie der Menschenthymus. Anat Hefte 43: 201-242

Hammar JA (1921) The new views as to the morphology of the thymus gland and their bearing on the problem of the function of the thymus. Endocrinology 5: 543-573, und 731-760

Hammar JA (1924) Uber progressive und regressive Formen Hassallscher Karper. Z Anat Entw 70:466-488

Hammar JA (1926) Die Menschenthymus in Gesundheit und Krankheit. Ergebnisse der numerischen Analyse von mehr als tausend menschlichen Thymusdriisen. Teil I: Das normale Organ. Zugleich eine kritische Beleuchtung der Lehre des "Status thymicus". Z Mikr-Anat. Forsch 6 [Suppl] 1-570

Hammar JA (1929) Die Menschenthymus in Gesundheit und Krankheit. Ergebnisse der numerischen Analyse von mehr als tausend menschlichen Thymusdriisen. Teil II: Das Organ unter anormalen Karperverhiiltnissen. Zugleich Grundlagen der Theorie der Thymusfunktion. Z Mikr-Ant Forsch 16 [Suppl] 1-1114

Hammar JA (1936) Die normal-morphologische Thymusforschung im letzten Vierteljahr­hundert. Analyse und Synthese nebst einigen Worten zu der Funktionsfrage. Joh. Ambros. Barth Leipzig

Haynes BF (1981) Human T lymphocyte antigens as defined by monoclonal antibodies. Immunol Rev 57:127-161

Hayward AR (1972) Myoid cells in the human foetal thymus. J Pathol106:45-49 Hayward AR (1981) Development oflymphocyte responses and interactions in the human

fetus and newborn. Immunol Rev 57: 39-60 Heiniger HJ, Riedwyl H, Giger H, Sordat B, Cottier H (1967) Ultrastructural differences

between thymic and lymph node small lymphocytes of mice: Nucleolar size and cyto­plasmic volume. Blood 30:288-300

Henry K (1966 I) Mucin secretion and striated muscle in the human thymus. Lancet 183-185

Henry K (1968 I) Striated muscle in human thymus. Lancet 638-639 Henry K (1972) An unusual thymic tumor with a striated muscle (myoid) component

(with a brief review of the literature on myoid cells). Brit J Dis Chest 66:291-299 Henry K, Farrer-Brown G (1981) A colour atlas of thymus and lymph node histopatho­

logy with ultrastrucure. Wolfe Medical Publications Ltd, London Hess MW (1970) Lymphatischer Apparat, insbesondere Thymus, in der Pathogenese

der Defektimmunopathien. In: Studer A, Cottier H (Hrsg) Immunreaktionen. Sprin­ger, Berlin Heidelberg New York (Handbuch der allgemeinen Pathologie, Bd. VII/3, S 182-236)

Hinrichsen K (1965) Zellteilungen und Zellwanderungen im Thymus der erwachsenen Maus. Z Zellforsch 68: 427-444

Hirokawa K (1969) Electron microscopic observation of the human thymus of the fetus and the newborn. Acta Pathol Jpn 19: 1-13

Hoshino T (1962) The fine structure of ciliated vesicle-containing reticular cells in the mouse thymus. Exp Cell Res 27: 615-617

Hoshino T (1963) Electron microscopic studies of the epithelial reticular cells of the mouse thymus. Z Zellforsch 59: 513-529

Topographie, makroskopische Anatomie, Histologie 253

Hoshino T, Kukita A, Sato S (1970) Cells containing Birbeck granules (Langerhans cell granules) in the human thymus. J Electron Microsc (Tokyo) 19:271-276

Humble JG, Jayne WHW, Pulvertaft RJV (1956) Biological interaction between lympho­cytes and other cells. Br J Haematol 2: 283-294

Hwang WS, Ho TY, Luk SC, Simon GT (1974) Ultrastructure of the rat thymus. A transmission, scanning electron microscope, and morphometric study. Lab Invest 31:473--487

Irvine WJ (1970) The thymus in autoimmune disease. Proc Roy Soc Med 63:718-722 Ito T, Hoshino T (1962) Histological changes of the mouse thymus during involution

and regeneration following administration of hydrocortisone. Z Zellforsch 56: 445-464

Ito T, Hoshino T (1966) Fine structure of the epithelial reticular cells of the medulla of the thymus in the golden hamster. Z Zellforsch 69:311-318

Ito T, Hoshino T, Abe K (1969) The fine structure of myoid cells in the human thymus. Arch Histol Jpn 30:207-215

Janossy G, Thomas JA, Bollum FJ, Granger S, Pizzolo G, Bradstock KF, Wong L, McMichael A, Ganeshaguru K, Hoffbrand AV (1980) The human thymic microenvi­ronment: An immunohistologic study. J ImmunoI125:202-212

Janossy G, Thoms JA, Goldstein G, Bollum FJ (1981) The human thymic microenviron­ment. In: Microenvironments in haemopoietic and lymphoid differentiation. Ciby Foundation Symposium 84. Pitman, London, pp 193-207

Jaroslow BN (1967) Genesis of Hassall's corpuscles. Nature 215:408--409 Joel DD, Hess MW, Cottier H (1971) Thymic origin oflymphocytes in developing Peyer's

patches of newborn mice. Nature New Biology 231 :24-25 Joel DD, Hess MW, Cottier H, (1972) Magnitude and pattern of thymic lymphocyte

migration in neonatal mice. J Exp Med 135: 907-923 Joel DD, Chanana AD, Cottier H, Cronkite EP, Laissue JA (1977) Fate of tymocytes:

Studies with 125I-Iododeoxyuridine and 3H-Thymidine in mice. Cell Tissue Kinet 10:57-69

Jones DL, Thomas K, Jones Williams W (1975) A fine structure of human thymus. Beitr Pathol 156: 387--400

Jordan HE, Horsley GW (1927) Significance of concentric corpuscles of Hasall. Anat Rec 35:279-303

Kaiserling E, Lennert K (1974) Die interdigitierende Retikulumzelle im menschlichen Lymphknoten. Eine spezifische Zelle der thymusabhiingigen Region. Virchows Arch [Cell Pathol] 16:51-61

Kaiserling E, Stein H, Miiller-Hermelink HK (1974) Interdigitating reticulum cells in the human thymus. Cell Tissue Res 155:47-55

Kameda Y (1971) The occurrence and distribution of the parafollicular cells in the thy­roid, parathyroid IV and thymus IV in some mammals. Arch Histol Jpn 33: 283-299

Kameya T, Watanabe Y (1965) Electron microscopic observations on human thymus and thymoma. Acta Pathol Jpn 15:223-246

Kao I, Drachman DB (1977) Thymus muscle cells bear acetylcholine receptors: Possible relation to myasthenia gravis. Science 195:74-75

Kapa E, Oh'th I, Toro I (1968) Electron microscopic investigation of the thymus of adult frog (Rana esculenta). Acta BioI Acad Sci Hung 19:203-213

Kater L (1973) A note on Hassall's corpuscles. In: Davies AJS, Carter RL (eds) Thymus dependency. Contemporary Topics in Immunobiology, Vol. II. Plenum Press, New York, London, pp 101-109

Kater L, Gorp LHM v (1969) Morphological aspects of Hassall's corpuscles. Pathol Europ 4: 361-369

Kato K, Ikeyama S, Takaoki M, Shino A, Takeuchi M, Kakinuma A (1981) Epithelial cell components immunoreact with anti-serum thymic factor (FTS) antibodies: Possi­ble association with intermediate-sized filaments. Cell 24: 885-895

Kohnen P, Weiss L (1964) An electron microscopic study of thymic corpuscles in the guinea pig and the mouse. Anat Rec 148:29-57

254 Literatur zu Teil 2

Kostowiecki M (1962) Development and degeneration of the second type of Hassall's corpuscles in the thymus of guinea pigs. Anat Rec 142: 195-203

Kostowiecki M (1964) Variety of central cells in Hasall's corpuscles of the human thymus. Z Mikr-Anat Forsch 71: 10-23

Kostowiecki M (1965) Primary human lyinphocytes as derivatives of the thymic epithelial cords. Z Mikr-Anat Forsch 73: 404--432

Kostowiecki M (1967) Development of the so-called double-walled blood vessels of the thymus. Z Mikr-Anat Forsch 77:401-431

Kotani M, Fukumoto T, Brandon MR (1981) Destruction of Hassall's corpuscles by macrophages in the sheep thymus. Cell Tissue Res 217:49-54

Kouvalainen K (1967) Significance of Hassall's corpuscles in the light of their morphologi­cal and histochemical appearance. Ann Med Exp Fenn 42:177-184

Kramarsky B, Siegler R, Rich MA (1967) Presence of endothelial fenestrations in thymic capillaries of mice. J Cell BioI 35: 464--467

Laissue JA, Chanana AD, Cottier H, Cronkite EP, Joel DD (1976) The fate of thymic radioactivity after local labeling with 125Iododeoxyuridine. Blood 47:21-30

LaPushin RW, DeHarven E (1971) A study of glucocorticosteroid-induced pyknosis in the thymus and lymph node of the adrenalectomized rat. J Cell BioI 50: 583-597

Ledbetter JA, Rouse RV Micklem HS, Herzenberg LA (1980) T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. J Exp Med 152:280-295

LeDouarin NM, Jotereau FV (1975) Tracing of cells of the avian thymus through embryo­nic life in interspecific chimera. J Exp Med 142: 17-40

Levine GD, Bearman RM (1980) The tliymus. In: Johannessen JV (ed) Electron micro­scopy in human medicine, Vol. 5: Cardiovascular system, lymphoreticular and hema­topoietic system. McGraw-Hill International Book Company, New York etc., pp 214-254

Levine GD, Rosai J (1978) Thymic hyperplasia and neoplasia: A review of current concepts. Hum PathoI9:495-515

London J, Berrih S, Bach J-F (1978) Peanut agglutinin. I. A new tool for studying T-lymphozyte subpopulations. J Immunol121 :438-443

Loning Th (1982) Immun- und Ultrastrukturpathologie der Mundschleimhaut. Regenera­tion, Entziindung, Hyperplasie, Priicancerose, Carcinom. Med-Habil-Schrift, Ham­burg

Loning Th, Caselitz J, Otto HF (1981) The epithelial framework of the thymus in normal and pathologic conditions. Immunohistochemical demonstration of keratin in an au­topsy series. Virchows Arch [pathol Anat] 392:7-20

Loning Th, Viac J, Caselitz J, Thivolet J, Otto HF, Seifert G (1982) Comparative investi­gation of keratinfilaments in normal tissues and tumours of skin, oral mucosa, salivary glands and thymus. Pathol Res Pract 175: 256-265

Lundin PM, Schelin U (1965) Ultrastructure of the rat thymus. Acta Pathol Microbiol Scand 65: 379-394

Mandel T (1968a) Ultrastructure of epithelial cells in the cortex of guinea pig thymus. Z Zellforsch 92: 159-168

Mandel T (1968b) Ultrastructure of epithelial cells in the medulla of the guinea pig thymus. Aust J Exp Bioi Med Sci 46:755-767

Mandel T (1968c) The development and structure of Hasall's corpuscles in the guinea pig. A light and electron microscopic study. Z Zellforsch 89: 180-192

Mandel T (1970) Differentiation of epithelial cells in the mouse thymus. Z Zellforsch 106:498-515

Marshall AHE, White RG (1961 Ia) Experimental thymic lesion resembling those of myasthenia gravis. Lancet, 1030

Marshall AHE, White RG (1961 Ib) The immunological reactivity of the thymus. Brit J Exp PathoI42:379-385

Mayer S (1888) Zur Lehre von der Schilddriise und Thymus bei den Amphibien. Anat Anz 3:97-103

Mayrhofer G, Bazin H (1981) Nature of the thymus dependency of mucosal mast cells.

Topographie, makroskopische Anatomie, Histologie 255

III. Mucosal mast cells in nude mice and nude rats, in B rats and in a child with the DiGeorge syndrome. Int Archs Allergy Appl Immuno164:320-331

McKenzie IFC, Potter T (1979) Murine lymphocyte surface antigens. Adv Immunol 27: 179-338

McMichael AJ, Pilch JR, Galfre G, Mason DY, Fabre JW, Milstein C (1979) A human thymocyte antigen defined by a hybrid myeloma monoclonal antibidy. Europ J Immu­noI9:205-210

McMillan EM, Wasik R, Everett MA (1982) OKT 6-positive cells. Their demonstration in human thymus, and the effect of fixation on the immunoperoxidase reaction. Arch Pathol Lab Med 106:9-12

Meihuizen SP, Burek JD (1978) The epithelial cell component of the thymuses of aged female BN/Bi rats. A light microscopic, electron microscopic, and autoradiographic study. Lab Invest 39: 613-622

MetcalfD (1966a) The nature nd regulation oflymphopoiesis in the normal and neoplas­tic thymus. In: Wolstenholme GEW, Porter R (eds) The thymus: Experimental and clinical studies. Ciba Foundation Symposium. J. and A. Churchill, Ltd. London, pp 242-263

Metcalf D (1966b) The thymus. Its role in immune responses, leukaemia development and carcinogenesis. Recent Results Cancer Res 5: 1-144

MetcalfD, Ishidate M (1961) Periodic Acid-Schiff positive giant cells in the mouse thymus cortex. Nature 191:305

Michalke WD, Hess MW, Riedwyl H, Stoner RD, Cottier H (1969) Thymic lymphopoie­sis and cell loss in newborn mice. Blood 33: 541-554

Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper MD (1977) Functional analysis of two human T-cell subpopulations: Help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG. J Exp Med 146:184-200

Miiller-Hermelink HK, Kaiserling E (1980) Different reticulum cells of the lymph node: Microecological concept of lymphoid tissue organization. In: Tweel JG van den (ed) Malignant lymphoproliferative diseases, Leiden University Press, The Hague Boston London, pp 57-70

Norris EH (1938) The morphogenesis and histogenesis of the thymus gland in man: In which the origin of the Hassall's corpuscles of he human thymus is discovered. Carnegie Inst. Wsh. Pub!. no. 496. Contrib Embryol 27: 191-221

Nossal GJV, Abbot A, Mitchell J (1968a) Antigens in immunity. XIV. Electron micro­scopic radioautographic studies of antigen capture in the lymph node medulla. J Exp Med 127: 263-276

Nossal GJV, Abbot A, Mitchell J, Lummus Z (1968b) Antigens in immunity. XV. Ultra­structural features of antigen capture in primary and secondary lymphoid follicles. J Exp Med 127:277-290

Ohih I, Rohlich P, Taro I (1975) Ultrastructure of lymphoid organs. An electron-micro­scopic atlas. Masson, Paris

Otto HF (1978) Untersuchungen zur Ultrastruktur lymphoepithelialer Thymustumoren unter besonderer Beriicksichtigung der sog. "Emperipolesis". Virchows Arch [pathol Anat] 379: 335-349

Palestro G, Valente G, Botto Micca F, Novero D, Arisio R (1980) Detection and distribu­tion of alfanaphthyl acetate esterase acitivity in thymocytes of normal, myasthenic thymus and thymoma. Histochemical and cytochemical study in relation to E-roset­ting. Virchows Arch [Cell Pathol] 35: 33---43

Pappenheimer AM (1910) A contribution to the normal and pathological histology of the thymus gland. J Med Res 22: 1-73

Pereira G, Clermont Y (1971) Distribution of cell webcontaining epithelial reticular cells in the rat thymus. Anat Rec 169:613-626

Pfoch M (1971) Vergleichende elektronenmikroskopische Untersuchung an entodermalen Thymus-Retikulumzellen neugeborener und alter Wistar-Ratten. Z Zellforsch 114:271-280

Pinkel D (1968) Ultrastructure of human fetal thymus. Am J Dis Child 115:222-238

256 Literatur zu Teil2

Puchtler H, Meloan SN, Branch BW, Gropp S (1971) Myoepithelial cells in human thymus: Staining, polarization and fluorescence microscopic studies. Histochemistry 45:163-176

Quaroni E (1956) Presenza di cellule preenterocromaffini argentofile nel timo di polIo. Riv Istochim Norm Pathol2: 185-187

Raff MC (1971) T and B lymphocytes in mice studied by using antisera against surface antigenic markers. Am 1 PathoI65:467-478

Ranga V, Ispas AT, Chirulesca ARM (1981) Elements of structure and ultrastructure of the blood-thymus barrier in ACTH involuted thymus. Acta Anat 111: 177-189

Rausch E, Kaiserling E, Goos M (1977) Langerhans cells and interdigitating reticulum cells in the thymus-dependent region in human dermatopathic lymphadenitis. Vir­chows Arch [Cell Pathol] 25:327-343

Raviola E, Karnovsky Ml (1972) Evidence for a blood-thymus barrier using electron­opaque tracers. 1 Exp Med 136: 466-498

Raviola E, Raviola G (1967) Striated muscle cells in the thymus of reptiles and birds: An electron microscopic study. Am 1 Anat 121: 623-646

Regaud CI, Cremieu R (1911 a) Evolution des corpuscles de Hassall dans Ie thymus rontgenise du chat. 1. Mechnanisme de l'accroissement de ces corpuscules. C r Soc BioI (paris) 71: 325-326

Regaud CI, Cremieu R (1911 b) Regression, instabilite, signification de ces corpuscles de Hassall. C r Soc BioI (Paris) 71: 383-384

Reggiani M (1946) Contributo alIa conoscenza delle cellule cromaffini del timo nel polIo. Boll Soc Ital BioI Sper 22: 108-109

Reinherz EL, Schlossman StF (1980a) The differentiation and function of human T lymphocytes. Cell 19 : 821-827

Reinherz EL, Schlossman StF (1980b) Regulation of the immune response. Inducer and suppressor T -lymphocyte subsets in human beings. New Eng! 1 Med 303: 370-373

Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman StF (1980a) Discrete stages of human intra thymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T -cell lineage. Proc N atl Acad Sci (USA) 77: 1588-1592

Reinherz EL, Kung PC, Goldstein G, Schlossman StF (1980b) A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2 • 1 Immunol124: 1301-1307

Renaut LJ (1899) Traite d'histologie practique, 2. Lecroenier et Babe, Paris Ritter MA, Sauvage CA, Cotmore SF (1981) The human thymus microenvironment:

In vivo identification of thymic nurse cells and other antigenically-distinct subpopula­tions of epithelial cells. Immunology 44: 439-446

Rosai 1, Higa E (1972) Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid tumor. Clinicopathologic study of 8 cases. Cancer 29: 1061-1074

Rosai 1, Levine GD (1976) Tumors of the thymus. In: Atlas of Tumor Pathology, Sec Ser, Fasc. 13. Armed Forces Institute of Pathology, Washington, DC

Rosai 1, Higa E, Davie 1 (1972) Mediastinal endocrine neoplasm in patients with mul­tiple endocrine adenomatosis. A previously unrecognized association. Cancer 29: 1075-1083

Rosai 1, Levine GD, Weber WR, Higa E (1976) Carcinoid tumors and oat cell carcinomas of the thymus. Pathol Annu 11 : 201-226

Rouse RV, Weissman IL (1981) Microanatomy of the thymus: Its relationship to T cell differentiation: In: Microenvironments in haemopoietic and lymphoid differentia­tion. Ciba Foundation Symposium 84. Pitman, London, pp 161-173

Sainte-Marie G (1966) The auto fluorescent cells of the rat thymus under certain experi­mental conditions. Proc Soc Exp BioI Med 122:696-700

Schambacher A (1903) Uber die Persistenz von Driisenkaniilen in der Thymus und ihre Beziehung zur Entstehung der Hassallschen Korperchen. Virchows Arch [Pathol Anat] 172:368-394

Schmitt D, Monier lC, Dardenne M, Pleau 1M, Deschaux P, Bach IF (1980) Cytoplasmic localization of FTS (facteur thymique serique) in thymic epithelial cells. An immuno­electronmicrscopical study. Thymus 2:177-186

Topographie, makroskopische Anatomie, Histologie 257

Shier KJ (1963) The morphology of the epithelial thymus. Observations On lymphocyte­depleted and fetal thymus. Lab Invest 12:316-326

Shier KJ (1981) The thymus according to Schambacher: Medullary ducts and reticular epithelium of thymus and thymomas. Cancer 48: 1183-1199 .

Sobotta J (1914) Anatomie der Thymusdriise (Glandula thymus). In: Bardeleben K v (Hrsg) Handbuch der Anatomie des Menschen, Bd. VI/3. Dritter Teil. Gustav Fischer, Jena, S 103-154

Soderstrom N, Axelsson JA, Hagelquist E (1970) Postcapillary venules of the lymph node in the thymus in myasthenia. Lab Invest 23:451-458

Steinman RM, Cohn ZA (1973) Identification of a novel cell type in peripheral lymphoid organs of mice, I. Morphology, quantitation, tissue distribution. J Exp Med 137: 1142-1162

Steinman RM, Witmer MD, Nussenzweig MC, Chen LL, Schlesinger S, Cohn ZA (1980) Dendritic cells of the mouse: Identification and characterization. J Invest Dermatol 75:14-16

Stutman 0 (1978) Intrathymic and extrathymic T cell maturation. Immunol Rev 42: 138-184

Sun T-T, Green H (1978) Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation. J BioI Chem 253:2053-2060

Thorbecke GJ, Silberberg-Sinakin I, Flotte ThJ (1980) Langerhans cells as macrophages in skin and lymphoid organs. J Invest Dermatol 75: 32-43

Tidman N, Janossy G, Bodger M, Granger S, Kung PC, Goldstein G (1981) Delineation of human thymocyte differentiation pathways utilizing double-staining techniques with monoclonal antibodies. Clin Exp ImmunoI45:457-467

Tomasi TB, Yurchak AM (1972) The synthesis of secretory component by the human thymus. J ImmunoI108:1132-1135

Veerman AJP, Ewijk W van (1975) White pulp compartments in the spleen of rats and mice. A light and electron microscopic study of lymphoid and nonlymphoid cells in T- and B-areas. Cell Tissue Res 156:417-441

Velde RL van de, Friedman NB (1966) The thymic "Myoidzellen" and myasthenia gravis. JAm Med Ass 198 :287-288

Velde RL van de, Friedman NB (1970) Thymic myoid cells and myasthenia gravis. Am J PathoI59:347-368

Veldman JE (1970) Histophysiology and electron microscopy of the immune response. Ph.D. Thesis Groningen. Drukkerij Dijkstra-Niemeyer, Groningen

Veldman JE, Molenaar I, Keuning FJ (1978) Electron microscopy of cellular immunity reactions in B-cell deprived rabbits. Thymus derived antigen reactive cells, their micro­environment and progeny in the lymph node. Virchows Arch [Cell Pathol] 28: 217-228

Vetters JM, MacAdam RF (1973) Fine structural evidence for hormone secretion by the human thymus. J Clin PathoI26:194-197

Viac J, Schmitt D, Staquet MJ, Thivolet J (1980) Epidermis-thymis antigenic relations with special reference to Hassall's corpuscles. Thymus 1: 319-328

Vialli M, Quaroni E (1956) Azione della reserpine sulle cellule enterocromaffini nel polIo. Riv Istochim Norm Pat 2: 111-116

Virchow R (1851) Die endogene Zellenbildung beim Krebs. Arch Pathol Anat Physiol 3: 197-227

Virchow R (1858) Die Cellularpathologie in ihrer Begriindung auf physiologische und pathologische Gewebelehre. August Hirschwald, Berlin

Waheed A (1936) Zur Topographie der Brustorgane beim menschlichen Fetus. Z Anat 106:558-574

Wassjutotschkin A (1918) Untersuchungen tiber die Histogenese der Thymus. Anat Anz 50:547-551

Watney H (1883) The minute anatomy of the thymus. Philosophical Transactins of the Royal Society of London. For the year MDCCCLXXXII. Vol. 173: 1063-1123 [Plates 83-95]

Weber K, Osborn M (1979) Microfilaments, micro tubules, and intermediate filaments

258 Literatur zu Teil 2

in immunofluorescence microscopy. In: Sato H (ed) Cell motility: Molecules and organization. University of Tokyo Press, pp 483--490

Weiss L (1963) Electron microscopic observations on the vascular barrier in the cortex of the thymus of the mouse. Anat Rec 145:413--437

Weiss L (1972) The cells and tissues of the immune system. Prentice-Hall Inc, Englewoods Cliffs., N.J

Weiss L (1977) The thymus. In: Weiss L, Greep RO (eds) Histology, 5th edn. McGraw­Hill, New York, pp 503-522

Weissman IL (1967) Thymus cell migration. J Exp Med 126:291-311 Wekerle H, Paterson B, Ketlsen U-P, Feldman M (1975) Striated muscle fibers differen­

tiate in monolayer cultures of adult thymus reticulum. Nature 256:493--494 Wekerle H, Ketelsen U-P, Ernst M (1980) Thymic nurse cells. Lymphoepithelial cell

complexes in murine thymuses: Morphological and serological characterization. J Exp Med 151:925-944

Wekerle H, Hohlfeld R, Ketelsen U-P, Kalden JR, Kalies I (1981) Thymic myogenesis, T-Iymphocytes and the pathogenesis of myasthenia gravis. Ann NY Acad Sci 377:455--475

White RG, Marshall AHE (1962 II) The autoimmune response in myasthenia gravis. Lancet, 120-123

Wiesel J (1912) Pathologie des Thymus. In: Lubarsch 0, Ostertag R (Hrsg) Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie des Menschen und der Tiere. 15. Jahrg., 2. Abt.: 1911. J.F. Bergmann, Wiesbaden, S 416-782

Funktion

Bach J-F, Papiernik M (1981) Cellular and molecular signals in T cell differentiation. In: Microenvironments in haemopoietic and lymphoid differentiation. Ciba Founda­tion Symposium 84. Pitman, London, pp 215-230

Cottier H (1980) Pathogenese. Bd. 2. Springer, Berlin Heidelberg New York Dardenne M, Pleau JM, Blouquit JY, Bach JF (1970) Characterization of facteur thy­

mique serique (FTS) in the thymus. II. Direct demonstration of the presence of FTS in thymosin fraction V. Clin Exp ImmunoI42:477--482

Dardenne M, Papiernik M, Bach J-F, Stutman 0 (1974) Studies on thymus products. III. Epithelial origin of the serum thymic factor. Immunology 27: 299-304

Davies AJS (1969) The thymus and the cellular basis of immunity. Transplant Rev 1 :43-91

Doherty PC, Blanden RV, Zinkernagel RM (1976) Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: Implications for H-antigen diver­sity. Transplant Rev 29:89-124

Duijvestijn AM, Hoefsmit ECM (1981) Ultrastructure of the rat thymus: The micro­environment of T -lymphocyte maturation. Cell Tissue Res 218: 279-292

Ewijk W v, Rouse RV, Weissman IL (1980) Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells. J Histochem Cytochem 28: 1089-1099

Goldstein AL, Asanuma Y, White A (1970) The thymus as an endocrine gland: Properties ofthymosin, a new thymus hormon. Rec Progr Hormone Res 26:505-532

Goldstein AL, Thurman GB, Cohen GH, Rossio JL (1976) The endocrine thymus: Poten­tial role for thymosin in the treatment of autoimmune disease. Ann NY Acad Sci 274:390--401

Goldstein G, Mackay IR (1969) The human thymus. William Heinemann Medical Books Ltd, London

Good RA, Gabrielsen AE (eds) (1967) The thymus in immunobiology. Structure, func­tion, and role in disease. Hoeber Medical Division, Harper & Row, Publishers, New York Evanston London

Good RA, Gabrielsen AE, Peterson RDA, Finstad J, Cooper MD (1966) The develop­ment of the central and peripheral lymphoid tissue: Ontogenetic and phylogenetic

Funktion 259

considerations. In: Wolstenholme GEW, Porter R (eds) The thymus: Experimental and clinical studies, Ciba Foundation Symposium. J. & A. Churchill Ltd, London, pp 181-206

Grouix B, Charreire J, Erard D, Galanaud P, Bach J-F (1981) Serum thymic factor (FTS) restores the ability of adult thymectomized mice to be suppressed by hapten­modified self. Cell Immunol 64: 144--149

Hammar JA (1912) Die Thymusliteratur im Referatenjahr 1911. Zentralbl Exp Med 1:23-33,175-182,458-467,743-751

Hammar JA (1936) Die normal-morphologische Thymusforschung im letzten Vierteljahr­hundert. Analyse und Synthese nebst einigen Worten zu der Funktionsfrage. Joh. Ambros. Barth, Leipzig

Hess MW (1968) Experimental thymectomy. Possibilities and limitations. Springer, Berlin Heidelberg New York

Hess MW (1970) Lymphatischer Apparat, insbesondere Thymus, in der Pathogenese der Defektimmunopathien. In: Studer A, Cottier H (Hrsg) Immunreaktionen. Sprin­ger, Berlin Heidelberg New York (Handbuch der allgemeinen Pathologie, Bd. VII/3, S 182-236)

Incefy GS, O'Reilly RJ, Kapoor N, Iwata T, Good RA (1981) In vitro differentiation of human marrow T cell precursors by thymic factors in severe combined immunodefi­ciency. Transplantation 32:299-305

Janossy G, Thomas JA, Bollum FJ, Granger S, Pizzolo G, Bradstock, KF, Wong L, McMichael A, Ganeshaguru K, Hoffbrand AV (1980) The human thymic microenvi­ronment: An immunohistologic study. J ImmunoI125:202-212

Janossy G, Thomas JA, Goldstein G, Bollum FJ (1981) The human thymic microenviron­ment. In: Microenvironments in haemopoietic and lymphoid differentiation. Ciba Foundation Symposium 84. Pitman, London, pp 193-207

Jenkinson EJ (1981) Expression and function of major histocompatibility complex anti­gens in the developing thymus: Studies on normal and nude mice. In: Microenviron­ments in haemopoietic and lymphoid differentiation. Ciba Foundation Symposium 84. Pitman, London, pp 178-187

Kato K, Ikeyama Sh, Takaoki M, Shino A, Takeuchi M, Kakinuma A (1981) Epithelial cell components immunoreact with anti-serum thymic factor (FTS) antibodies: Possi­ble association with intermediate-sized filaments. Cell 24: 885-895

Metcalf D (1966) The Thymus. Its role in immune responses, leukaemia development and carcinogenesis. Recent Results Cancer Research, 5: 1-144

Miller JFAP (196111) Immunological function of the thymus. Lancet, 748-749 Miller JFAP (1962) Effect of neonatal thymectomy on the immunological responsiveness

of the mouse. Proc Roy Soc 156:415-428 Miller JFAP (1966) The thymus in relation to the development of immunological capacity.

In: Wolstenholme GEW, Porter R (eds) The thymus: Experimental and clinical stu­dies. Ciba Foundation Symposium. J. and A. Churchill Ltd, London, pp 153-174

Miller JFAP, Dukor P (1964) Die Biologie des Thymus nach dem heutigen Stand der Forschung. Akademische Verlagsgesellschaft, Frankfurt a.M.

Miller JFAP, Mitchell GF (1969) Thymus and antigen-reactive cells. Transplant Rev 1:3-42

Miller JFAP, Osoba D (1963) The role of the thymus in the origin of immunological competence. In: Wolstenholme GEW, Knight J (eds) The immunologically competent cell: Its nature and origin. Ciba Foundation Study Group No. 16. J. & A. Churchill, London, pp 61-70

Miller JFAP, Osoba D (1967) Current concepts of the immunological function of the thymus. Physiol Rev 47:437-520

Monier JC, Dardenne M, Pleau JM, Schmitt D, Deschaux P, Bach JF (1980) Characteri­zation of facteur thymique serique (FTS) in the thymus. I. Fixation of anti-FTS antibodies on thymic reticulo-epithelial cells. Clin Exp ImmunoI42:470-476

Oosterom R, Kater L, Rademarks LHPM (1981) How unique is the thymus? Conditioned media from thymus and tonsil epithelial cultures share biological activities in T-cell maturation. Clin Immunol ImmunopathoI19:428-436

260 Literatur zu Teil2

Owen JJT (1970) Ontogenesis of immunobiological systems. In: Studer A, Cottier H (Hrsg) Immunreaktionen. Springer, Berlin Heidelberg New York (Handbuch der all­gemeinen Pathologie, Bd. VII/3, S 129-181)

Parrott DMV, East J (1962) Strain variation in mortality and runt disease in mice thymec­tomized at birth. Tansplantation 29: 102-104

Ritter MA, Sauvage CA, Cotmore SF (1981) The human thymus microenvironment: In vivo identification of thymic nurse cells and other antigenically-distinct subpopula­tions of epithelial cells. Immunology 44:439-446

Rouse RV, Weissman IL (1981) Microanatomy of the thymus: Its relationship to T cell differentiation. In: Microenvironments in haemopoietic and lymphoid differentia­tion. Ciba Foundation Symposium 84. Pitman, London, pp 161-173

Schmitt D (1981) Interactions peau-Iymphocytes T-thymus: Une nouvelle approche en immunopathologie cutanee? Pathol BioI 29: 393-397

Schmitt D, Monier JC, Dardenne M, Pleau JM, Deschaux P, Bach JF (1980) Cytoplasmic localization of FTS (facteur thymique serique) in thymic epithelial cells. An immuno­electronmicroscopical study. Thymus 2:177-186

Sherman JD, Turner M (1969) Post-thymectomy wasting disease and intestinal bacterial flora. Arch PathoI87:29-34

Teodorczyk JA, Potoworowski EF, Siculis A (1975) Cellular localisation and antigenic species specificity of thymic factors. Nature 258: 617-619

Tidman N, Janossy G, Bodger M, Granger S, Kung PC, Goldstein G (1981) Delineation of human thymocyte differentiation pathways utilizing double-staining techniques with monoclonal antibodies. Clin Exp Immunol 45: 457-467

Viac J, Schmitt D, Staquet MJ, Thivolet J (1980) Epidermis-thymus antigenic relations with special reference to Hassall's corpuscles. Thymus 1 :319-328

Zinkernagel RM (1978a) Thymus and lymphohemopoietic cells: Their role in T cell maturation, in selection of T cells, H-2-restriction-specificity and in H-2-linked Ir gene control. Immunol Rev 42: 224--270

Zinkernage1 RM (1978b) Speculations on the role of major transplantation antigens in cell-mediated immunity against intracellular parasites. Curr Top Microbiol Immu­noI82:113-138

Thymus-Involution

Boyd E (1936) Weight of the thymus and its component parts and number of Hassall corpuscles in health and disease. Am J Dis Child 51: 313-335

Constantian MB, Menzoian JO, Nimberg RB, Schmid K, Mannick JA (1977) Association of a circulating immunosuppressive polypeptide with operative and accidental trauma. Ann Surg 185:73-79

Cowan WK, Sorenson GD (1964) Electron microscopic observations of acute thymic involution produced by hydrocortisone. Lab Invest 13:353-370

Dourov N (1970) L'atrophie thymo-Iymphatique chez Ie nourrisson aprt!s traitement prolonge Ii l'ACTH. Pathol Europ 5:216-231

Dourov N (1974) Study of the cytoplasmic lipids in thymic involution. Pathol Europ 9:43-57

Goldstein G, Mackay IR (1969) The human thymus. William Heinemann Medical Books Ltd, London

Grouls V, Helpap B (1978) DNA-synthesis in the rat thymus after focal thermolesions on abdominal organs. Res Exp Med (Bed) 173:229-237

Haelst U v (1967) Light and electron microscopic study of the normal and pathological thymus of the rat. II. The acute thymic involution. Z Zellforsch 80: 153-182

Hammar JA (1905) Zur Histogenese und Involution der Thymusdriise. Anat Anz 27: 23-30 und 41-89

Hammar JA (1909) Fiinfzig Jahre Thymusforschung. Kritische Ubersicht der normalen Morphologie. Ergebn Anat Entwickl-Gesch 19: 1-274

Hammar JA (1936) Die normal-morphologische Thymusforschung im letzten Vierteljahr­hundert. Analyse und Synthese nebst einigen Worten zu der Funktionsfrage. Joh. Ambros. Bart, Leipzig

Defektimmunopathien 261

He1pap B, Dachselt U (1978) The pattern of lymphocytes in the thymus and spleen after labeling with 3H-Thymidine and 3H-Deoxycytidine. Virchows Arch [Cell Pathol] 28:287-299

Helpap B, Grouls V (1980a) Cell kinetic investigations of the thymus after different tissue lesions in parenchymal organs. Virchows Arch [Cell Pathol] 34: 277-289

Helpap B, Grouls V (1980b) Der EinfluB einer granulierenden und resorbierenden Ent­ziindung auf den Thymus. Verh Dtsch Ges PathoI64:236-240

Henry L (1968) "Accidental" involution of the human thymus. J Pathol Bact 96: 337-343 Hiesche KD, Revesz L (1979) Effect of cortisone and X-irradiation on cellular depletion

and regeneration in the thymus of mice: Experimental discrimination between thymus lymphocyte precursors in the bone marrow and in the thymus. Pathol Rec Pract 164:157-166

Ito T, Hoshino T (1962) Histologic changes of the mouse thymus during involution and regeneration following administration of hydrocortisone. Z Zellforsch 56: 445-464

Jonson A (1909) Studien iiber die Thymusinvolution. Die akzidentelle Involution bei Hunger. Arch Mikr Anat 73: 390-443

LaPushin RW, DeHarven E (1971) A study of gluco-corticosteroid-induced pycnosis in the thymus and lymph node of the adrenalectomized rat. J Cell BioI 50:583-597

Lundin M, Schelin U (1966) The effect of steroids on the histology and ultrastructure of lymphoid tissue. I. Acute thymic involution. Pathol Europ 1: 15-28

Lundin M, Schelin U (1968) The effect of steroids on the histology and ultrastructure of lymphoid tissue. II. Regeneration of the rat thymus after pronounced involution. Pathol Europ 3: 531-541

Lundin M, Schelin U (1969) The effect of steroids on the histology and ultrastructure oflymphoid tissue. III. Thymus in prolonged steroid induced involution. Pathol Europ 4:58-68

Meyer JA, Meyer JD (1978) Splenectomy and the thymic involution of increasing age. Arch Surg 113:972-975

Meyer JD, Meyer JA (1977) Prevention by splenectomy of thymus weight depe1etion in the presence of progressively growing tumor in rats: Brief communication. J Natl Cancer Inst 59: 1023-1026

Myking AO (1979a) Responses of the thymus and the paracortex of draining lymph nodes to repeated applications of Oxazolone to mouse skin. Virchows Arch [Cell Pathol] 32:11-20

Myking AO (1979b) Dose dependency of the responses in draining lymph nodes and skin to repeated application of Oxazolone. A quantitative and histological study in mice. Virchows Arch [Cell Pathol] 32:21-31

Seemayer ThA, Lapp WS, Bolande RP (1977) Thymic involution in murine graft-versus­host reaction. Am J Pathol 88: 119-134

Tosi P, Luzi P, Miracco C, Vecchio MT del, Vindigni C (1982) Effects of 7,12-dimethyl­benz (A) anthracene on thymus cortex in the rat. Virchows Arch [Cell Pathol] 39: 125-136

Trowell QA (1961) Radiosensitivity of the "Cortical and medullary lymphocytes in the thymus. Int J Radiat BioI 4: 163-169

Defektimmunopathien

Adkins WY, Gussen R (1974) Temporal bone findings in the third and fourth pharyngeal pouch (DiGeorge) syndrome. Arch OtolaryngoI100:206-208

Aldrich RA, Steinberg A, Campbell DC (1954) Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics 13: 133-138

Ambrus JL, Ambrus CM (1973) Disorders of the thymus gland and thymus transplanta­tion in man. In: Luckey TD (ed) Thymic hormones. Urban & Schwarzenberg, Miin­chen Berlin Wien, pp 19-38

Ammann AJ, Fudenberg HH (1978) Immunodeficiency diseases. In: Fudenberg HH, Stites DP, Daldwell JL, Wells JV (eds) Basis and clinical immunology. Lange Medical Publications, Los Altos, pp 391-421

262 Literatur zu Teil 2

Ammann AJ, Good RA, Bier D, Fudenberg HH (1969) Longterm plasma infusions in a patient with Ataxia te1eangiectasia and deficient IgA and IgE. Pediatrics 44:672-676

Ammann AJ, Wara DW, Doyle NE, Golbus MS (1975) Thymus transplantation in patients with thymic hypoplasia and abnormal immunoglobulin synthesis. Transplant 20:457-466

Ammann AJ, Wara DW, Allen T (1978) Immunotherapy and immunopathologic studies in a patient with nucleoside phosphorylase deficiency. Clin Immunol Immunopathol 10:262-269

Beschorner WE, Hutchins GM, Elfenbein GJ, Santos GW (1978) The thymus in patients with allogenic bone marrow transplants. Am J Pathol 92: 173-186

Bienenstock J, McDermott M, Befus AD, O'Neill M (1978) A common mucosal immuno­logic system involving the bronchus, breast and bowel. In: McGhee JR, Mestecky J, Babb JL (eds) Secretory immunity and infection. Plenum Press, New York, pp 53-66

Black FO, Spanier SS, Kohut RI (1975) Aural abnormalities in partial DiGeorge syn­drome. Arch Otolaryngol101: 129-134

Blaese RM, Strober W, Brown RS, Waldmann TA (19681) The Wiskott-Aldrich syn­drome: A disorder with a possible defect in antigen processing or recognition. Lan­cet: 1056-1061

Blaese RM, Strober W, Levy AL, Waldmann TA (1971) Hypercatabolism of IgG, 19A, IgM and albumin in the Wiskott-Aldrich syndrome. J Clin Invest 50:2331-2338

Blaese RM, Strober W, Waldmann TA (1975) Immunodeficiency in the Wiskott-Aldrich syndrome. Birth Defects 11 :250-254

Bochkov NP, Lopukhin YM, Kovalchuk NP (1974) Cytogenetic study of patients with Ataxia-teleangiectasia. Humangenetik 24:225-238

Bockman DE, Lawton AR, Cooper MD (1972) Fine structure of thymus after bone marrow transplantation in an infant with severe combined immunodeficiency. Lab Invest 26: 227-239

Boder E (1975) Ataxia-teleangiectasia: Some historic, clinical, and pathologic observa­tions. Birth Defects 11: 255-270

Boder E, Sedgwick RP (1958) Ataxia-teleangiectasia. A familial syndrome of progressive cerebellar ataxia, oculocutaneous teleangiectasia and frequent pulmonary infection. Pediatrics 21: 526-554

Boder E, Sedgwick RP (1963) Ataxia-teleangiectasia: A review of 101 cases. In: Walsh G (ed) Cerebellum posture and cerebral palsy, Vol 8. London: Little Club Clin Deve­lop Med, National Spastics Society, Medical, Education and Information Unit, pp 110-118

Borzy MS, Hong R, Horowitz SD, Gilbert E, Kaufman D, DeMendonca W, Oxelius V-A, Dictor M, Pachman L (1979 a) Fatal lymphoma after transplantation of cultured thymus in children with combined immunodeficiency disease. New Engl J Med 301:565-568

Borzy MS, Schulte-Wissermann H, Gilbert E, Horowitz SD, Pellett J, Hong R (1979b) Thymic morphology in immunodeficiency diseases: Results of thymic biopsies. Clin ImmunollmmunopathoI12:31-51

Brand MM, Marinkovich VA (1969) Primary malignant reticulosis of the brain in Wis­kott-Aldrich syndrome. Report of a case. Arch Dis Childh 44:536-542

Broder S, Uchiyama T, Waldmann TA (1979) Neoplasms of immunoregulatory cells. Am J Clin Pathol 72:724-731

Buckley RH, Gilbertsen RB, Schiff RI, Ferreira E, Sanal SO, Waldmann TA (1976) Heterogeneity of lymphocytes subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect. J Clin Invest 58: 130-136

Burnet M (1961) The immunological recognition of self. Science 133:307 Burnet M (1970) The concept of immunological surveillance. Prog Exp Tumor Res

13:1-27 Chandra RK, Cooper MD, Hitzig WH, Rosen FS, Seligmann M, Soothill JF, Terry

RJ (1979) Immunodeficiency. Report of a WHO Scientific Group. Clin Immunol Immunopathol 13: 296-359

Defektimmunopathien 263

Cohen SR, Stenn KS, Braverman 1M, Beck GJ (1980) Mycosis fungoides: Clinicopatholo­gic relationship, survival, and therapy in 59 patients with observations on occupation as a new prognostic factor. Cancer 46:2654-2666

Cooper MD, Chase HP, Lowman JT, Krivit W, Good RA (1968) Wiskott-Aldrich syn­drome. An immunologic deficiency disease involving the afferent limb of immunity. Am J Med 44:499-513

Cooper MD, Perrey DY, Peterson RDA, Gabrielsen AE, Good RA (1968) The two­component concept of the lymphoid system. In: Bergsma D, Good RA (eds) Immuno­logic deficiency diseases in man. US Natl Found Original Article Series IV, pp 7-12

Cooper MD, Faulk WP, Fudenberg HH, Good RA, Hitzig HW, Kunkel H, Rosen FS, Seligmann M, Soothill J, Wedgwood RJ (1973a) Classification of primary im­munodeficiencies. New Engl J Med 288: 966-967

Cooper MD, Keightley RG, Wu L-Y, Lawton AR (1973b) Developmental defects of T and B cell lines in humans. Transplant Rev 16:51-84

Cooper MD, Faulk WP, Fudenberg HH, Good RA, Hitzig HW, Kunkel HG, Roitt 1M, Rosen FS, Seligmann M, Soothill JF, Wedgwood RJ (1974) Primary immunodefi­ciencies. Meeting report of the second International Workshop on primary immuno­deficiency diseases in man. Clin Immunol ImmunopathoI2:416-445

Cottier H (1957) Zur Histopathologie des Antikorpermagelsyndroms. Trans 6th Congr Europ Soc Haemat, Copenhagen, pp 41-46

Cottier H (1980) Pathogenese, Bd 2. Springer, Berlin Heidelberg New York Cottier H, Hess MW, Roos B, Gretillat PA (1969) Regeneration, Hyperplasie und Onko­

genese der lymphoretikuliiren Organe. In: Buchner F (Hrsg) Handbuch der allgemei­nen Pathologie, Bd VI/2. Springer, Berlin Heidelberg New York, S 496-766

Daguillard F, Garneau R, Deschenes L, Chouinard C, Fudenberg HH, Schanfield M (1973) Hyperactive production of antibody of a boy with thymic dysplasia undergoing graft versus host reaction. Clin Immunol Immunopathol 2: 52-61

DeVaal OM, Seynhaeve V (1959 II) Reticular dysgenesia. Lancet 1123-1125 DiGeorge AM (1965) A new concept of the cellular basis of immunity. J Pediatr

67:907-908 DiGeorge AM (1968) Congenital absence of the thymus and its immunologic consequen­

ces: Concurrence with congenital hypoparathyroidism. Birth Defects 4: 116-121 Doherty PC, Korngold R, Schwartz DH, Bennink JR (1981) Development and loss

of virus-specific thymic competence in bone marrow radiation chimeras and normal mice. Immunol Rev 58:37-72

Dosch HM, Lee JWW, Gelfand EW, Falk JA (1978) Severe combined immunodeficiency disease. A model ofT cell dysfunction. Clin Exp Immuno134:260---267

Dunn HG, Meuwissen H, Liningstone CS, Pump KK (1964) Ataxia-teleangiectasia. Can Med Assoc J 91: 1106-1117

Filipovich AH, Krivit W, Kersey JH, Burke BA (1979) Fatal arthritis as a complication of Wiskott-Aldrich syndrome. J Pediatr 95: 742-744

Fireman Ph, Johnson HA, Gitlin D (1966) Presence of plasma cells and YlM-globulin synthesis in a patient with thymic alymphoplasia. Pediatrics 37:485-492

Fogh J, Giovanella BC (eds) (1978) The nude mouse in experimental and clinical reserach. Academic Press, New York San Francisco London

Freedom RM, Rosen FS, Nadas AS (1972) Congenital cardiovascular disease and anoma­lies of the third and fourth pharyngeal pouch. Circulation 46: 165-172

Fudenberg HH, Good RA, Goodman HC, Hitzig W, Kunkel HG, Roitt 1M, Rosen FS, Rowe DS, Seligmann M, Soothill JR (1971) Primary immunodeficiencies. Report of a World Health Organization Committee. Pediatrics 47:927-946

Gatti RA, Good RA (1971) Occurrence of malignancy in immunodeficiency diseases. Cancer 28: 89-98

Gatti RA, Gershanik n, Levkoff AH, Wertelecki W, Good RA (1972) DiGeorge syn­drome associated with combined immunodeficiency: Dissociation of phytohemagglu­tinin and mixed leukocyte culture responses. J Pediatr 81 :920---926

Gatti RA, Gershanik n, Levkoff AH, Wertelecki W, Good RA (1973) Combined system immunodeficiency with DiGeorge syndrome and dissociation of PHA/MCC respon­ses. Adv Exp Med BioI 29:327-336

264 Literatur zu Teil 2

Geha RS (1976) Is the B-cell abnormality secondary to T-cell abnormality in severe combined immunodeficiency? Clin Immunol Immunopathol11 : 292-302

Gitlin D, Craig JM (1963) The thymus and other lymphoid tissues in congenital agamma­globulinemia. I. Thymus alymphoplasia and lymphocytic hypoplasia and their relation to infection. Pediatrics 32:517-530

Gitlin D, Rosen FS, Janeway CA (1964) The thymus and other lymphoid tissues in congenital agammaglobulinemia. II. Delayed hypersensitivity and homograft survival in a child with thymic alymphoplasia. Pediatrics 33: 711-720

Gitlin D, Vawter G, Craig JM (1964) Thymic alymphoplasia and congenital aleukocyto­sis. Pediatrics 33:184-192

Glanzmann E, Riniker P (1950) Essentielle Lymphocytophthise. Wien Med Wochenschr 100:35-36

Goldsmith CI, Hart WR (1975) Ataxia-teleangiectasia with ovarian gonadoblastoma and contralateral dysgerminoma. Cancer 36: 1838-1842

Good RA (1972) Relations between immunity and malignancy. Proc Nat! Acad Sci (USA) 69:1026-1032

Good RA, Cooper MD, Peterson RDA (1966) The role of the thymus in immune process. Ann NY Acad Sci 135:451-478

Good RA, Peterson RDA, Perrey DY, Finstad J, Cooper MD (1968) The immunological deficiency diseases of man: Consideration of some questions asked by these patients with an attempt at classification. Birth Defects 4: 17-30

Gosseye S, Nezelof C (1981) T system immunodeficiencies in infancy and childhood. Pathol Res Pract 171: 142-158

Grogan THM, Broughton DD, Doyle WF (1975) Graft-versus-host reaction (GVHR). A case report suggesting GVHR occurred as a result of matemofetal cell transfer. Arch Patho199:330-334

Gupta S, Good RA (1978) Subpopulations of human T lymphocytes. V. T lymphocytes with receptors for immunoglobulin M or G in patients with primary immunodeficiency disorders. Clin Immunol Immunopathol11 :292-302

Haerer AF, Jackson JF, Evers CG (1969) Ataxia-teleangiectasia with gastric carcinoma. JAm Med Ass 210: 1884-1887

Haferkamp 0 (1974) Der schutzlose Organismus. Dtsch med Wochenschr 99:203-210 Harhaway WE, Brangle RW, Nelson TL, Roeckel IE (1966) Aplastic anemia and alym­

phocytosis in an infant with yhpogammaglobulinemia: Graft-versus-host reaction? J Pediatr 68: 713-722

Hathaway WE, Fulginiti VA, Pierce CW, Githens JH, Pearlman DS, Muschenheim F, Kempe CH (1967) Graft-versus-host reaction following a single blood transfusion. JAm Med Ass 201 :1015-1020

Hausen H zur (1981) Virusinfektionen des hiimatopoietischen Systems: das Epstein-Barr­Virus und andere bisher wenig charakterisierte Virusinfektionen. Verh Dtsch Ges PathoI65:146-151

Haworth JC, Hoogstraten J, Taylor H (1967) Thymic alymphoplasia. Arch Dis Child 42:40-54

Hecht F, McCaw B, Koler RD (1973) Ataxia-teleangiectasia: Clonal growth oftransloca­tion lymphocytes. New Engl J Med 289:286-291

Heremans JF (1975) The secretory immune system: A critical appraisal. In: Neter E, Milgram F (eds) The immune system and infectious disease. Karger, Basel, pp 91-100

Hess MW (1970) Lymphatischer Apparat, insbesondere Thymus, in der Pathogenese der Defektimmunopathien. In: Studer A, Cottier H (Hrsg) Immunreaktionen. Sprin­ger, Berlin Heidelberg New York (Handbuch der allgemeinen Pathologie, Bd VII/3, S 182-236)

Hess MW, Schiideli J, Cottier H (1971) Pathogenese und Pathomorphologie kindlicher Immunopathien. Verh Dtsch Ges Pathol55: 175-189

Heymer B, Niethammer D, Haas R, Meister H, Haferkamp 0 (1976) Pathomorphologic findings in severe combined immunodeficiency and reticular dysgenesia. Virchows Arch [Pathol Anat] 370: 151-162

Defektimmunopathien 265

Hirschhorn R, Vawter GF, Kirkpatrick JA, Rosen FS (1979) Adenosine deaminase defi­ciency: Frequency and comparative pathology in autosomally recessive severe combi­ned immunodeficiency. Clin Immunol Immunopathol14: 107-120

Hitzig WH (1973) Congenital thymic and lymphocytic deficiency disorders. In: Stiehm ER, Fulgininiti V (eds) Immunologic disorders in infants and children. Saunders, Philadelphia, pp 215-235

Hitzig WH (1974) Immunmangel-Krankheiten. Pathophysiologie und Klinik. In: Schwiegk H (Hrsg) Handbuch der inneren Medizin, Bd VII/1. Springer, Berlin Heidel­berg New York, S 681-760

Hitzig WH (1979) Angeborene und erworbene Immundefekte des Magen-Darm-Kanals. Z Gastroenterol Verh-Bd 14:25-36

Hitzig WH, Biro Z, Bosch H, Huser HJ (1958) Agammaglobuliniimie und Alymphocytose mit Schwund des lymphatischen Gewebes. Helv Paediatr Acta 13:551-585

Hitzig WH, Barandun S, Cottier H (1968) Die schweizerische Form der Agammaglobulin­iimie. Ergebn Inn Med Kinderheilkd 27: 79-154

Hong R, Gatti RA, Good RA (1968 II) Hazards and potential benefits ofblood-transfu­sion in immunological deficiency. Lancet 388-389

Hong R, Santosham M, Schulte-Wissermann H, Horowitz S, Hsu SH, Winkelstein JA (1976 II) Reconstitution of Band T lymphocyte function in severe combined immuno­deficiency disease after transplantation with thymic epithelium. Lancet 1270-1272

Hong R, Horowitz SD, Borzy MF, Gilbert EF, Arya S, McLod N, Peterson RDA (1981) The cerebrohepato-renal syndrome of Zellweger: Similarity to and differentia­tion from the DiGeorge syndrome. Thymus 3:97-104

Hoover R, Fraumeni JF (197311) Risk of cancer in renaltransplant recipients. Lancet 55-57

Houchens DP, Ovejera AA (eds) (1978) Proceedings of the Symposium on the use of athymic (nude) mice in cancer research. Fischer, New York Stuttgart

Janeway ChA (1968) Progress in immunology: Syndromes of diminished resistance to infection. J Pediatr 72: 885-903

Kaufman DB, Miller HC (1977) Ataxia teleangiectasia: An autoimmune disease associa­ted with a cytotoxic antibody to brain and thymus. Clin Immunol Immunopathol 7:288-299

Kersey JH, Spector BD, Good RA (1973) Primary immunodeficiency diseases and cancer: The immunodeficiency-cancer registry. Int J Cancer 12:333-347

Kersey JH, Spector BD, Good RA (1973) Immunodeficiency and cancer. Adv Cancer Res 18:211-230

Knutsen AP, Rosse WF, Kinney ThS, Buckley RH (1981) Immunologic studies before and after splenectomy in a patient with the Wiskott-Aldrich syndrome. J Clin Immu­noll: 13-19

Kondo K, Horikawa Y (1975) Spinocerebellar degeneration: Ataxia-teleangiectasia and malignant tumor. Naika (lnt Med) (Jpn) 35:623-626

Konorza GG, Krueger GRF, Evers KG (1978) Combined immune deficiency snydromes with primary T-cell defect and partial B-cell reactive hyperactivity. Immunological and morphological analysis of two unusual cases. Virchows Arch [pathol Anat] 378:329-340

Kretschmer R, Say B, Brown D (1978) Congenital aplasia of the thymus gland (DiGeor­ge's syndrome). New Engl J Med 279:1295-1301

Kumar GK, Saadi AA, Sheng A Y, McCaughery RS (1979) Ataxia-teleangiectasia and hepatocellular carcinoma. Am J Med Sci 278: 157-160

Lamvik J, Moe PJ (1969) Thymic dysplasia with immunological deficiency. Acta Pathol Microbiol Scand 76: 349-360

Lancet editorial: A.D.A. deficiency. Lancet 1976/1, 895-896 Lawlor GJ, Ammann AJ, Wright WC, LaFranchi S, Bilstrom D, Stiehm ER (1974)

The syndrome of cellular immunodeficiency with immunoglobulins. J Pediat 84:183-192

Lennert K, Schwarze E-W, Kruger G (1981) Lymphknotenveriinderungen durch Virus­infektionen. Verh Dtsch Ges PathoI65:151-171

266 Literatur zu Teil 2

Levin S, Perlov S (1971) Ataxia-teleangiectasia in Israel: with observation on its relation­ship to malignant disease. Isr J Med Sci 7: 1535--1541

Lischner HW (1972) DiGeorge syndrome(s). J Pediatr 81: 1041-1044 Lischner HW, DiGeorge AM (196911) Role of the thymus in humoral immunity: Obser­

vations in complete or partial congenital absence of the thymus. Lancet 1044-1049 Lischner HW, Dacou C, DiGeorge AM (1967) Normal lymphocyte transfer (NLT) test:

negative response in a patient with congenital absence of the thymus. Transplantation 5:555--557

Lischner HW, Punnett HR, DiGeorge AM (1967) Lymphocytes in congenital absence of the thymus. Nature (Lond) 214: 580-582

Little BW, Tihen WS, Dickerman JD, Craighead JE (1981) Giant cell pneumonia associa­ted with parainfluenza virus type 3 infection. Hum PathoI12:478-481

Louis-Bar D (1941) Sur un syndrome progressif comprenant des teleangiectasies capillai­res cutanees et conjunctivales symmetriques, a disposition naevoide et de troubles cerebelleux. Confin Neurol (Basel) 4: 32-42

Lum LG, Tubergen DG, Carcish L, Blaese RM (1980) Splenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome. New Engl J Med 302:892-896

MacFarlin DE, Strober W, Waldmann TA (1972) Ataxia-teleangiectasia. Medicine 51:281-314

McCaw BK, Hecht F, Harnden DG, Teplitz R (1975) Somatic rearrangement of chromo­some 14 in human lymphocytes. Proc Natl Acad Sci (USA) 72:2071-2075

McKusick VA, Cross HE (1966) Ataxia-teleangiectasia and Swiss-type agammaglobulin­emia. Two genetic disorders of the immune mechanism in related Amish sibships. JAmMed Ass 195:739-745

Meuwissen HJ, Pollara B (1978) Combined immunodeficiency and inborn errors of purine metabolism. Blut 37:173-181

Meuwissen HJ, Pollara B, Pickering RJ (1975) Combined immunodeficiency disease asso­ciated with adenosine-deaminase deficiency. J Pediatr 86:169-181

Miller JFAP, Dukor P (1964) Die Biologie des Thymus nach dem heutigen Stande der Forschung. Akademische Verlagsgesellschaft, Frankfurt

NezelofC (1968) Thymic dysplasia with normal immunoglobulins and immunologic defi­ciency: pure almyphocytosis. Birth Defects 4: 104-112

Nezelof C, Jammet ML, Lortholary P, Labrune B, Lamy M (1964) L'hypoplasia heredi­taire du thymus. Sa place et sa responsabilite dans une observation d'aplasie lympho­cytaire normo-plasmocytaire et normoglobulinemique du nourrisson. Arch Fr Pediatr 21:897-920

Niethammer D, Goldmann SF, Flad H-D, Meigel W, Tollner U, Pohlandt F, Heymer B, Kleihauer E (1979) Graft-versus-host reaction after blood transfusion in a patient with cellular immunodeficiency: The role of histocompatibility testing. Europ J Pe­diatr 132:43-48

Ochs HD, Slichter SJ, Harker LA, Behrens WE von, Clark RA, Wedgwood RJ (1980) The Wiskott-Aldrich syndrome: Studies of lymphocytes, granulocytes and platelets. Blood 55: 243-252

Oppenheim n, Blaese RM, Waldmann TA (1970) Defective lymphocyte transformation and delayed hypersensitivity in Wiskott-Aldrich syndrome. J ImmunoI104:835-844

Page AR, Hansen AE, Good RA (1963) Occurrence of leukemia and lymphoma in patients with agammaglobulinemia. Blood 21: 197-261

Pahwa RN, Pahwa SG, Good RA (1978) T-Iymphocyte differentiation in severe combined immunodeficiency: Defects of the thymus. Clin Immunol Immunopathol 14:437-444

Pahwa R, Pahwa S, O'Reilly R, Good RA (1978) Treatment of the immunodeficiency diseases - Progress toward replacement therapy emphasizing cellular and macromole­cular engineering. Springer Semin Immunopathol 1: 355-404

Pahwa S, Pahwa R, Incefy G, Reece E, Smithwick E, O'Reilly R, Good RA (1979) Failure of immunologic reconstitution in a patient with the DiGoerge syndrome after fetal thymus transplantation. Clin Immunol Immunopathol 14: 96-106

Defektimmunopathien 267

Perry GS, Spector BD, Schuman LM, Mandel JS, Anderson VE, McHugh RB, Hanson MR, Fahlstrom SM, Krivit W, Kersey JH (1980) The Wiskott-Aldrich syndrome in the United States and Canada (1892-1979). J Pediatr 97:72-78

Perryman LE, Buening GM, McGuire TC, Torbeck RL, Poppie MJ, Sale GE (1979) Fetal tissue transplantation for immunotherapy of combined immunodeficiency in horses. Clin Immunol ImmunopathoI12:238-251

Peterson RDA, Kelly WD, Good RA (1964 I) Ataxia-teleangiectasia. Its association with a defective thymus, immunological deficiency disease and malignancy. Lancet 1189-11193

Polmar SH, Stein RC, Schwartz AL, Wetzler EM, Chase PA, Hirschhorn R (1976) Enzyme replacement therapy for adenosine deaminase deficiency and servere combi­ned immunodeficiency. New Engl J Med 295: 1337-1343

Purtilo DT (1981) Malignant lymphoproliferative diseases induced by Epstein-Barr virus in immunodeficient patients, including X-linked, cytogenetic, and familial syndormes. Review article. Cancer Genet Cytogenet 4:251-268

Pyke KW, Dosch HM, Ipp MM, Gelfand EW (1975) Demonstration of an intrathymic defect in a case of severe combined immunodeficiency disease. New Engl J Med 293:424-428

Radaszkiewicz Th, Eibl M, Jarisch R, Lachmann D (1975) Inkompletter, kombinierter, familiarer Immundefekt mit generalisierter Impftuberkulose durch Bacille Calmette Guerin. Virchows Arch [Pathol Anatj366:341-351

Radl J, Dooren LJ, Morell A, Skvaril F, Vossen MJJ, Vittenbogaart CH (1976) Immuno­globulins and transient paraproteins in sera of patients with the Wiskott-Aldrich syndrome: A follow-up study. Clin Exp ImmunoI25:256-263

Rivat-Peran L, Buriot D, Salier J-Ph, Rivat C, Dumitresco S-M, Griscelli C (1981) Immunoglobulins in Ataxia-teleangiectasia: Evidence for IgG4 and IgA2 subclass deficiencies. Clin Immunol Immunopathol 20: 99-110

Robinson HB (1975) DiGorge's or the III-IV pharyngeal pouch syndrome: Pathology and a theory of pathogenesis. Perspect. Pediatr Pathol 2: 173-206

Rosen FS (1972) Immunity deficiency in children. Brit J Clin Pract 26:315-322 Rosen FS, Gitlin D, Janeway CA (1962 II) Alymphocytosis, agammaglobulinemia, homo­

grafts and delayed hypersentivity: Study of a case. Lancet 380-381 Rosen FS, Craig JM, Vawter G, Janeway CA (1968) The dysgammaglobulinemias and

X-linked thymic hypoplasia. In: Bergsma D, Good RA (eds) Immunologic diseases in man. US Natl Found Original Article Series IV, pp 67-70

Ross IN, Asquith P (1979) Primary immune deficiency. In: Asquith P (ed) Immunology of the gastrointestinal tract. Chruchill Livingstone, Edinburgh, London New York, pp 152-182

RossIe R (1932) Uber gleichzeitige MiBbildungen der branchiogenen Organe und fiber angeborenen Mangel der Epithelkorperchen. Virchows Arch [Pathol Anatj283 :41-57

RossIe R (1938) Uber den angeborenen Mangel der Epithelkorperchen. Schweiz Med Wochenschr 68: 848-849

Rygaard J (1973) Thymus and self. Immunobiology of the mouse mutant nude. F.A.D.L, Copenhagen

Saulsbury FT, Winkelstein JA, Yolken RH (1980) Chronic rotavirus infection in immuno­deficiency. J Pediatr 97: 61-65

Schwartz RS (1972 I) Immunoregulation, oncogenic viruses, and malignant lymphomas. Lancet 1266-1269

Schwartz RS (1975) Another look at immunologic surveillanc. New Engl J Med 293:181-184

Sedgwick RP, Boden E (1972) Ataxia-teleangiectasia. In: Vinicen PJ, Bruyn GW (eds) A handbook of clinical neurology, Vol 14. North Holland Publishing Company, Amsterdam, pp 267-339

Seeger RC, Robins RA, Stevens RH, Klein RB, Waldman DJ, Zeltzer PM, Kessler SW (1976) Severe combined immunodeficiency with B lymphocytes: In vitro correc­tion of defective immunoglobulin production by addition of normal T lymphocytes. Clin Exp ImmunoI26:1-10

268 Literatur zu Teil2

Seligmann M, Hitzig WH (eds) (1980) Primary immunodeficiencies. ElsevierfNorth Hol­land, Amsterdam

Seligmann M, Fudenberg HH, Good RA (1968) A proposed classification of primary immunologic deficiencies. Am J Med 45: 817-824

Snover DC, Frizzera C, Spector BD, Perry GS, Kersey JH (1981) Wiskott-Aldrich syn­drome: Histopathologic findings in the lymph nodes and spleens of 15 patients. Hum PathoI12:821-831

Souteyrand P, Thivolet J (1981) Mycosis fungoides and Sezary syndrome. Pathol Res Pract 171:240-261

Spector BD, Good RA, Kersey JH (1978) Immunodeficiency diseases and malignancy. In: Lipkin M, Good RA (eds) Gastrointestinal tract cancer. Plenum Medical Book Comp, New York London, pp 51-70

Spector BD, Perry GS, Kersey JH (1978) Genetically determined immunodeficiency disea­ses (GDID) and malignancy: Report from the immunodeficiency-cancer registry. Clin Immunol Immunopatholll : 12-29

Spitler LE, Levin AS, Stites DP, Fudenberg HH, Huber H (1975) The Wiskott-Aldrich syndrome: Immunologic studies in nine patients and selected family members. Cell ImmunoI19:201-218

Swift M, Sholman L, Perry M, Chase C (1976) Malignant neoplasma in the families of patients with ataxia-teleangiectasia. Cancer Res 36:209-215

Takemoto KK, Rabson AS, Mullarkey MF, Blaese RM, Garon CF, Nelson D (1974) Isolation of papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome. J Natl Cancer Inst 53: 1205-1207

Thomas L (1959) Reactions to homologous tissue antigens in relation to hypersensitivity. In: Lawrence HS (ed) Cellular and humoral aspects of the hypersensitive states. Hoeber-Harper, New York, pp 529-532

Tobler R, Cottier H (1958) Familiare Lymphopenie mit Agammaglobulinamie und schwe­rer Moniliasis. Die "essentielle Lymphocytophthise" als besondere Form der friihkind­lichen Agammaglobulinamie. Helv Pediatr Acta 13:313-338

Touraine J-L (1979) Human T-Iymphocyte differentiation in immunodeficiency diseases and after reconstitution by bone marrow or fetal thymus transplantation. Clin Immu­noIImmunopathoI12:228-237

Touraine J-L, Betuel H (1981) Immunodeficiency diseases and expression of HLA anti­gens. Hum ImmunoI2:147-153

Touraine J-L, Betuel H, Souillet G, Jeune M (1978) Combined immunodeficiency disease associated with absence of cell-surface HLA-A and -B antigens. J Pediatr 93 :47-51

Waldmann TA, McIntire KR (1972 II) Serum-alpha-fetoprotein levels in patients with ataxia-teleangiectasia. Lancet 1112-1115

Watanabe A, Hanazono H, Sogawa H, Takaya H (1977) Stomach cancer ofa 14-year-old boy with ataxia-teleangiectasia. Tohoku J Exp Med 121: 121-131

Wiskott A (1937) Familiarer, angeborener Morbus Werlhofii? Monatsschr Kinderheilkd 68:212-216

Yoshitomi F, Zaitsu Y, Tanaka K (1980) Ataxia-teleangiectasia with renal cell carcinoma and hepatoma. Virchows Arch [pathol Anat] 389:119-125

Zinkernagel RM (1981) Die Bedeutung virusindizierter zellularer Immunreaktionen. Verh Dtsch Ges PathoI65:11-14

Thymushyperplasie

Aarli JA, Heimann P, Matre R, Thunold S, Tonder 0 (1979) Lymphocyte subpopulations in thymus and blood from patients with myasthenia gravis. J Neurol Neurosurg Psychiat 42:29-34

Abbot A, Burnet FM (1964) Electron microscopy of the thymus lesions in NZB mice. J Pathol Bact 88: 243-245

Abdou NI, Lisak RP, Zweiman B, Abrahamsohn I, Penn AS (1974) The thymus in myasthenia gravis. Evidence for altered cell populations. New Engl J Med 291: 1271-1275

Thymushyperplasie 269

Alpert LI, Papatestas A, Kark A, Osserman RS, Osserman K (1971) A histologic reap­praisal of the thymus in myasthenia gravis. A correlative study of thymic pathology and response to thymectomy. Arch Pathol 91: 55-61

Althoff H (1980) Sudden infant death syndrome (SIDS). Forensic-medical experience, research and conclusions regarding a general medical problem. In: Biingeler W, Eder M, Lennert K, Peters G, Sandritter W, Seifert G (Hersg) Veroffentlichungen aus der Pathologie. Progress in Pathology, Vol 114, 2nd ed. Fischer, Stuttgart New York

Balzereit F, Bay V, Otto HF, Rittmeyer P, Sobirey Chr (1972) Die Thymektomie im Behandlungsplan der Myasthenie. Z Neurol201: 136-159

Bargman W (1943) Der Thymus. In: MollendorffW v (Hrsg) Handbuch der mikroskopi­schen Anatomie des Menschen, Bd VI/4. Springer, Berlin, S 1-172

Bell ET (1917) Tumors of the thymus in myasthenia gravis. J Nerv Ment Dis 45: 130--143 Bender AN, Ringel StP, Engel WK, Daniels MP, Vogel Z (1975 I) Myasthenia gravis:

A serum factor blocking acetylcholine receptors of the human neuromuscular junction. Lancet 607-608

Bender AN, Ringel StP, Engel WK, Vogel Z, Daniels MP (1976) Immunoperoxidase localization of alpha Bungarotoxin: A new approach to myasthenia gravis. Ann NY Acad Sci 274:20--30

Beutner EH, Fazekas G, Scott A, Witebsky E (1966) Direct fluorescent antibody studies of gamma globulin localization in muscle of patients with myasthenia gravis. Ann NY Acad Sci 135: 588-600

Biggart JD, Nevin NC (1967) Hyperplasia of the thymus in progressive systemic sclerosis. J Pathol Bact 93:334-337

Boyd E (1936) Weight of the thymus and its component parts and number of Hassall corpuscles in health and in disease. Am J Dis Child 51: 313-335

Bratton AB (1925) The normal weight of the human thymus. J Pathol Bact 27:609-620 Burnet FM (1966) Mast cells in the mouse thymus. In: Wolstenholme GEW, Porter

R (eds) The thymus: Experimental and clinical studies. Ciba Foundation Symposium. Churchill, London, pp 335-340

Burnet FM, Holmes MC (1964) Thymic changes in the mouse strain NZB in relation to the auto-immune state. J Pathol Bact 88:229-241

Burnet FM, Mackay IR (1962 II) Lymphoepithelial structures and autoimmune disease. Lancet 1030--1033

Buzzard EF (1905) The clinical history and postmortem examination of five cases of myasthenia gravis. Brain 28: 438-483

Castleman B (1966) The pathology of the thymus gland in myasthenia gravis. Ann NY Acad Sci 135:496-505

Castleman B, Norris EH (1949) The pathology of the thymus in myasthenia gravis. Medicine 28:27-58

Christensson B, Biberfeld P, Matell G (1978) Immunological characteristics ofa subpopu­lation of thymus cells in myasthenia gravis. Scand J Immunol 8: 153 (Abstr)

Christensson B, Matell G, Biberfeld P (1980) Immunological studies on human thymus. Occurence and distribution of immunoglobulins and immunological receptors in myasthenia gravis and control patients. Acta Med Scand 208: 161-168

Chused ThM, Moutsopoulos HM, Sharrow SO, Hansen CT, Morse HC (1978) Mecha­nism of autoimmune disease in New Zealand Black mice. In: Rose NR, Bigazzi PE, Warner NL (eds) Genetic control of autoimmune disease. Developments in Immu­nology, Vol I. Elsevier/North-Holland, New York Amsterdam Oxford, pp 177-190

Clarke RR, Velde RL van de (1971) Congenital myasthenia gravis. A case report with thymectomy and electron microscopic study of resected thymus. Am J Dis Child 122:356-361

Corridan M (1963) The thymus in hepatic cirrhosis. J Clin PathoI16:445-447 Datta SK, Schwartz RS (1978) Genetic, viral and immunologic aspects of autoimmune

disease in NZB mice. In: Rose NR, Bigazzi PE, Warner NL (eds) Genetic control of autoimmune disease. Developments in Immunology, Vol I. Elsevier/North-Hol­land, New York Amsterdam Oxford, pp 193-203

Dawkins RL (1975) Experimental autoallergic myositis, polymyositis and myasthenia

270 Literatur zu Teil2

gravis. Autoimmune muscle disease associated with immunodeficiency and neoplasia. Clin Exp Immunol 21: 185-201

Doerr W (1974) Thymus. In: Doerr W (Hrsg) Organpathologie, Bd III. Thieme, Stuttgart, S 12.1-12.8

Drachman DB, Angus CW, Adams RN, Michelson JD, Hoffman GJ (1978) Myasthenic antibodies cross-link acetylcholine receptors to accelerate degradation. New Engl J Med 298: 1116-1122

Engel AG, Tsujihata M, Lindstrom JM, Lennon VA (1976) The motor end plate in myasthenia gravis and in experimental autoimmune myasthenia gravis. A quantitative ultrastructural study. Ann NY Acad Sci 274:60-79

Engel AG, Lindstrom JM, Lambert EH, Lennon VP (1977a) Ultrastructural localization of the acetylcholine receptor in myasthenia gravis and in its experimental autoimmune model. Neurology 27: 307-325

Engel AG, Lambert EH, Howard FM (1977b) Ultrastructural localization of immune complexes (IgG and C3) at the neuromuscular junction in myasthenia gravis. Neuro­logy 27: 364 (Abstr)

Engel AG, Lambert EH, Howard FM (1977c) Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis. Ultrastructural and light microscopic locali­zation and electrophysiologic correlations. Mayo Clin Proc 52: 267-280

Engel AG, Lambert EH, Gomez MR (1977 d) A new myasthenic syndrome with end-plate acetylcholinesterase deficiency, small nerve terminals and reduced acetylcholine re­lease. Ann NeuroI1:315-330

Engel AG, Lambert EH, Mulder DM, Gomez MR, Whitaker IN, Hart Z, Sahashi K (1981 a) Recently recognized congenital myasthenic syndromes: (A) End-plate acetyl­choline (ACh) esterase deficiency (B) Putative abnormality of the ACh induced ion channel (C) Putative defect of ACh resynthesis or mobilization - Clinical features, ultrastructure and cytochemistry. Ann NY Acad Sci 377:614-637

Engel AG, Sahashi K, Fumagalli G (1981 b) The immunopathology of acquired myasthe­nia gravis. Ann NY Acad Sci 377:158-174

Fambrough DM, Drachman DB, Satyamurti S (1973) Neuromuscular junction in myas­thenia gravis: Decreased acetylcholine receptors. Science 182: 293-295

Freeman StS, Engel AG, Drachman DB (1976) Experimental acetylcholine blockade of the neuromuscular junction. Effects on end plate and muscle fiber ultrastructure. Ann NY Acad Sci 274:46-59

Fulpius BW, Zurn AD, Granato DA, Leder RM (1976) Acetylcholine receptor and myasthenia gravis. Ann NY Acad Sci 274:116-129

Gelfand DW, Goldman AS, Law EJ, MacMillian BG, Larson D, Abston S, Schreiber JT (1972) Thymic hyperplasia in children recovering from thermal bums. J Trauma 12:813-817

Genkins G, Papatestas AE, Horowitz StH, Kornfeld P (1975) Studies in myasthenia gravis: Early thymectomy. Electrophysiologic and pathologic correlations. Am J Med 58:517-524

Goldstein AL, Slater FD, White A (1966) Preparation, assay and partial purification of a thymus lymphocytopoietic factor. Proc Natl Acad Sci (USA) 56: 1010-1017

Goldstein AL, Asanuma Y, White A (1970) The thymus as an endocrine gland: Properties of thymosin, a new thymus hormone. Rec Prog Horm Res 26: 505-538

Goldstein AL, Thurman GB, Cohen GH, Rossio JL (1976) The endocrine thymus: Poten­tial role for thymosin in the treatment of autoimmune disease. Ann NY Acad Sci 274:390-401

Goldstein G (1966a) Plasma cells in the human thymus. Aust J Exp BioI Med Sci 44:695-699

Goldstein G (1966 lIb) Thymitis and myasthenia gravis. Lancet 1164-1167 Goldstein G (1968 II) The thymus and neuromuscular function. A substance in thymus

which causes myositis and myasthenic neuromuscular block in guinea pigs. Lancet 119-123

Goldstein G, Hoffmann WW (1968) Electrophysiological changes similar to those of myasthenia gravis in rats with experimental autoimmune thymitis. J Neurol Neurosurg Psychiat 31 :453-459

Thymushyperplasie 271

Goldstein G, Hoffmann WW (1969) Endocrine function of the thymus affecting neuro­muscular transmission. Clin Exp Immunol4: 181-189

Goldstein G, Mackay IR (1965) Contrasting abnormalities in the thymus in systemic lupus erythematosus and myasthenia gravis. A quantitative histological study. Aust J Exp BioI Med Sci 43:381-390

Goldstein G, Mackay IR (1967 II) The thymus in systemic lupus erythematosus: A quantitative histopathological analysis and comparison with stress involution. Brit Med J 475-478

Goldstein G, Mackay IR (1969) The human thymus. W. Heinemann Medical Books Ltd,London

Goldstein G, Abbot A, Mackay IR (1968) An electron-microscope study of the human thymus: Normal appearances and findings in myasthenia gravis and systemic lupus erythematosus. J PathoI95:211-215

Gomez CH, Richman DP, Burres SA, Amason BGW, Berman PW, Fitch FW (1981) Monoclonal hybridoma antiacetylcholine recoptor antibodies: Antibody specificity and effect of passive transfer. Ann NY Acad Sci 377:97-109

Greenwood M, Woods HM (1927) "Status thymico-Iymphaticus" considered in the light of recent work on the thymus. J Hyg 26:305-326

Grob D, Brunner NG, Namba T (1981) The natural course of myasthenia gravis and effect of therapeutic measures. Ann NY Acad Sci 377: 652-669

Habu S, Kameya T, Tamaoki N (1971) Thymic lymphoid follicles in autoimmune disea­ses. I. Quantitative studies with special reference to myasthenia gravis. Keio J Med 20:45-56

Haller JA, Mazur DO, Morgan WW (1969) Diagnosis and management of mediastinal masses in children. J Thorac Cardiovasc Surg 58: 385-393

Hammar JA (1926) Die Menschenthymus in Gesundheit und Krankheit. Ergebnisse der numerischen Analyse von mehr als tausend menschlichen Thymusdriisen. Teil I: Das normale Organ. Zugleich eine kritische Beleuchtung der Lehre des "Status thymicus". Z Mikrosk Anat Forsch 6 [Suppl] 1-570

Hammarstrom L, Smith E, Moller E, Franksson C, Matell G, Reis G von (1975) Myasthe­nia gravis: Studies on HL-A antigens and lymphocyte subpopulations in patients with myastenia gravis. Clin Exp Immunol21 :202-215

Hare WSC, Mackay IR (1969) Thymic size in systemic lupus erythematosus. Arch Intern Med 124:60--63

Hart C (1912) Thymusstudien. II. Die Thymuselemente. Virchows Arch [pathol Anat] 210:255-277

Hart C (1913) Thymusstudien. III. Die Pathologie der Thymus. Virchows Arch [Pathol Anat] 214: 1-83

Hart C (1915) Thymusstudien. V. Thymusbefunde bei Myasthenia gravis pseudoparaly­tica. Virchows Arch [Pathol Anat] 220: 185-213

Henry K (1972) An unusual thymic tumour with a striated muscle (myoid) component (with a brief review of the literature on myoid cells). Brit J Dis Chest 66:291-299

Hertel G, Mertens HG, Ricker K, Schimrigk K (Hrsg) (1977) Myasthenia gravis und andere Storungen der neuromuskularen Synapse. Thieme, Stuttgart

Hutchins GM, Harvey AM (1964) The thymus in systemic lupus erythematosus. Johns Hopkins Med J 115:355-378

Kalden JR (1970) Die Pathogenese der Myasthenia gravis als immunologisches Problem. Klin W ochenschr 48: 4--13

Kalden JR (1977) Immunpathogenetische Mechanismen. In: Hertel G, Mertens HG, Ricker K, Schimrigk K (Hrsg) Myasthenia gravis und andere Storungen der neuro­muskularen Synapse. Thieme, Stuttgart, S 10--19

Kalies I, Kalden JR, Heinz F, Janzen RWCh, Lachenmayer L (1979) Nachweis von Acetylcholin-Rezeptor-Antikorpern im Serum von Myasthenia gravis-Patienten unter Verwendung affinitatschromatographisch gereinigter humaner Acetylcholin-Rezep­tor-Praparationen. Klin Wochenschr 57: 875-881

Kamegaya K, Tsuchiya M, Sambe K (1971) Thymic abnormalities and the chronicity of liver disease. Report of 10 cases and follow-up study. Keio J Med 20:77-90

Katz SM, Chatten J, Bishop HC, Rosenblum H (1977) Massive thymic enlargement.

272 Literatur zu Teil 2

Report of a case of gross thymic hyperplasia in a child. Am J Clin Pathol 68: 786-790

Klose H (1912) Chirurgie der Thymusdriise. In: Bruns P von (Hrsg) Neue Deutsche Chirurgie, Bd 3. Ferdinand Enke, Stuttgart

Kouvalainen K, Wallgren GR (1967) The thymus in myasthenia gravis with special reference to the significance of Hassall's corpuscles. Ann Med Exp BioI Fenn 45:112-116

Lack EE (1981) Thymic hyperplasia with massive enlargement. Report of two cases with review of diagnostic criteria. J Thorac Cardiovasc Surg 81: 741-746

Lamesch AJ Massive thymic hyperplasia in infants. J Pediat Surg (im Druck) Laquer L, Weigert C (1901) Beitrage zur Lehre von der Erb'schen Krankheit. I. Ueber

die Erb'sche Krankheit (Myasthenia gravis). II. Pathologisch-anatomischer Beitrag zur Erb'schen Krankheit (Myasthenia gravis). Neurol Zentralbl 20: 594-601

Lee Y, Moallem S, Clauss RH (1979) Massive hyperplastic thymus in a 22-month-old infant. Ann Thorac Surg 27: 356-358

Lennon VA (1978) The immunopathology of myasthenia gravis. Hum Pathol 9: 541-551 Lennon VA, Lambert EH (1981) Monoclonal autoantibodies to acetylcholine receptors:

Evidence for a dominant idiotype and requirement of complement for pathogenicity. Ann NY Acad Sci 377:77-95

Lennon VA, Lindstrom JM, Seybold ME (1975) Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs. J Exp Med 141: 1365-1375

Lennon VA, Lindstrom JM, Seybold ME (1976) Experimental autoimmune myasthenia gravis: Cellular and humoral immune responses. Ann NY Acad Sci 274: 283-299

Levine GD, Bearman RM (1980) The thymus. In: Johannessen JV (ed) Electron micro­scopy in human medicine, Vol 5. McGraw-Hill International Book Comp, New York etc., pp 214-254

Levine GD, Dorfman RF (1975) Follicular (nodular) lymphoma. An ultrastructural study of its relationship to germinal centers and a correlation of light and electron microsco­pic findings. Cancer 35: 148-164

Levine GD, Rosai J (1978) Thymic hyperplasia and neoplasia: A review of current concepts. Hum PathoI9:495-515

Lindstrom J, Lennon VA, Seybold ME, Whittingham S (1976) Experimental autoimmune myasthenia gravis and myasthenia gravis: Biochemical and immunochemical aspects. Ann NY Acad Sci 274:254-274

Lindstrom J, Tzartos S, Gullick W (1981) Structure and function of the acetylcholine receptor molecule studied using monoclonal antibodies. Ann NY Acad Sci 377: 1-19

Lisak RP, Abdou NI, Zweiman B, Zmijewski Ch, Penn AS (1976) Aspects of lymphocyte function in myasthenia gravis. Ann NY Acad Sci 274:402-410

Lisak RP, Zweiman B, Phillips SM (1977) Thymic and peripheral blood T-cell and B-celllevels in myasthenia gravis. Neurology 27: 365-366 (Abstr)

Lisak RP, Zweiman B, Phillips SM (1978) Thymic and peripheral blood T- and B-cell levels in myasthenia gravis. Neurology 28: 1298-1301

Mackay IR (1966) Histopathology of the human thymus. In: Wolstenholme GEW, Porter R (ed) The thymus: Experimental and clinical studies. Ciba Foundation Symposium. Churchill, London, pp 449-464

Mackay IR, Gail P de (1963 II) Thymic "germinal centers" and plasma cells in systemic lupus erythematosus. Lancet 667

Mackay IR, Whittingham S, Goldstein G, Currie TT, Hare WSC (1968) Myasthenia gravis: Clinical, serological, and histological studies in relation to thymectomy. Aust NZJ Med 17:1-11

Matsuno K, Yamanaka N, Kotani M (1981) Demonstration of B lymphocytes in rat thymic lymph follicles. Arch Histol J pn 44: 369-372

Middleton G (1967) The incidence of follicular structures in the human thymus at autopsy. Aust J Exp BioI Med Sci 45: 189-199

Mizuno Y, Shimabukuro K, Kurita K, Tsuchiya M (1976) Thymus abnormalities in ulcerative colitis - comparative study with other autoimmune diseases. Gastroenterol Jpn 11 :208-214

Monnier VM, Fulpius BW (1977) A radioimmunoassay for the quantitative evaluation

Thymushyperplasie 273

of antihuman acetylcholine receptor antibodis in myasthenia gravis. Clin Exp Immu­noI29:1&-22

Nastuk WL, Stra,us~ . .AJI:" Osserman KE (1959) Search for a neuromuscular blocking agent in the blood of patients with myasthenia gravis. Am J Med 26: 394-409

Okabe H (1966) Thymic lymph follicles: A histopathological study of 1,356 autopsy cases. Acta Pathol Jpn 16:109-130

Oosterhuis HJGH (1977) Ergebnisse der Thymektomie in Beziehung zur Thymushistolo­gie. In: Hertel G, Mertens HG, Ricker K, Schimrigk K (Hrsg) Myasthenia gravis und andere Storungen der neuromuskuliiren Synapse. Thieme, Stuttgart, S 237-241

Oosterhuis HJ (1981) Observations of the natural history of myasthenia gravis and the effect of thymectomy. Ann NY Acad Sci 377: 678-690

O'Shea PA, Pansatiankul B, Farnes P (1978) Giant thymic hyperplasia in infancy: Immu­nologic, histologic, and ultrastructural observations. Lab Invest 38: 391 (Abstr)

Paltauf A (1889) Ueber die Beziehungen der Thymus zum plotzlichen Tod. Wien Klin Wochenschr 2:877-881

Paltauf A (1890) Ueber die Beziehungen der Thymus zum plotzlichen Tod. Wien klin Wochenschr 3: 172-175

Papatestas AE, Alpert LI, Osserman KE, Osserman RS, Kark AE (1971) Studies in myasthenia gravis: Effects of thymectomy. Results on 185 patients with nonthymoma­tous and thymomatous myasthenia gravis, 1941-1969. Am J Med 50:465-474

Papatestas AE, Genkins G, Horowitz StH, Kornfeld P (1976) Thymectomy in myasthenia gravis: Pathologic, clinical, and electrophysiologic correlations. Ann NY Acad Sci 274:555-573

Papatestas AE, Genkins G, Kornfeld P (1981) Comparison of the results of the transcervi­cal and transsternal thymectomy in myasthenia gravis. Ann NY Acad Sci 377: 76&-778

Patrick J, Lindstrom J (1973) Autoimmune response to acetylcholine receptor. Science 180:871-872

Perlo VP, Amason B, Castleman B (1975) The thymus gland in elderly patients with myasthenia gravis. Neurology 25:294-295

Perlo VP, Amason B, Poskanzer D, Castleman B, Schwab RS, Osserman KE, Papatestas AE, Alpert L, Kark A (1971) The role of thymectomy in the treatment of myasthenia gravis. Ann NY Acad Sci 183:308-315

Porter CW, Barnard EA (1976) Ultrastructural studies on the acetylcholine receptor at motor end plates of normal and pathologic muscles. Ann NY Acad Sci 274:85-107

Potter EL (1961) Pathology of the fetus and infant, 2nd ed. Year Book Medical Pub­lishers, Chicago

Rash JE, Hudson CS, Albuquerque EX, Eldefrawi ME, Mayer RF, Graham WF, John­son TJA, Giddings FD (1981) Freeze-fracture, labelled-replica, and electrophysiologi­cal studies of junctional fold destruction in myasthenia gravis and experimental auto­immune myasthenia gravis. Ann NY Acad Sci 377: 38-59

Reinglass JL, Brickel AC (1973) The prognostic significance of thymic germinal center proliferation in myasthenia gravis. Neurology 23: 69-72

Rosai J, Levine GD (1976) Tumors of the thymus. In: Atlas of Tumor Pathology, Sec Ser, Fasc 13. Armed Forces Institute of Pathology, Washington DC

Rubin JW, Ellison RG, Moore HV, Pai GP (1981) Factors affecting response to thymec­tomy for myasthenia gravis. J Thorac Cardiovasc Surg 82: 720-728

Sack W, Staber FG (1977) B-Lymphoyten im Thymusgewebe. In: Hertel G, Mertens HG, Ricker K, Schimrigk K (Hrsg) Myasthenia gravis und andere Storungen der neuromuskuliiren Synapse. Thieme, Stuttgart, S 2&-32

Sambrook MA, Reid H, Mohr PD, Boddie HG (1976) Myasthenia gravis: Clinical and histological features in relation to thymectomy. J Neurol Neurosurg Psychiat 39: 38-43

Sanders DB, Kim YI, Howard JF, Johns TR, Muller WH (1981) Intercostal muscle biopsy studies in myasthenia gravis: Clinical correlations and the direct effects of drugs and myasthenic serum. Ann NY Acad Sci 377: 544-565

Schadewald H (1977) Zur Geschichte der Myasthenia gravis. In: Hertel G, Mertens HG, Ricker K, Schimrigk K (Hrsg) Myasthenia gravis und andere Storungen der neuromuskuliiren Synapse. Thieme, Stuttgart, S 1-4

Schmid KO (1970) Thymus und Colitis ulcerosa. Verh Dtsch Ges PathoI54:313-318

274 Literatur zu Teil 2

Schmincke A (1922) Uber Thymushyperplasie. Klin Wochenschr 1 :2025-2029 Schmincke A (1926) Pathologie des Thymus. In: Henke F, Lubarsch 0 (Hrsg) Drusen

mit innerer Sekretion. Springer, Berlin Heidelberg New York (Handbuch der speziel­len pathologischen Anatomie und Histologie, Bd VIII, S 760-809

Simpson JA (1960) Myasthenia gravis. A new hypothesis. Scot Med J 5:419-436 Simpson JA, Behan PO, Dick HM (1976) Studies on the nature of autoimmunity in

myasthenia gravis. Evidence for an immunodeficiency type. Ann NY Acad Sci 274:382-389

Sloan HE (1943) The thymus in myasthenia gravis with observations on the normal anatomy and histology of the thymus. Surgery 13: 154-174

Smithers DW (1959) Tumours of the thyroid gland in relation to some general concepts of neoplasia. J Facult Radiol 10: 3-16

Soderstrom N, Axelsson J-A, Hagelqvist E (1970) Postcapillary venules of the lymph node type in the thymus in myasthenia. Lab Invest 23:451-458

Staber FG, Fink U, Sack W (1975) B lymphocytes in the thymus of patients with myasthe­nia gravis. New Engl J Med 292:1032-1033

Strauss AJL, van der Geld HWR (1966) The thymus and human diseases with auo­immune concomitants, with special reference to myasthenia gravis. In: Wolstenholme GEW, Porter R (eds) The thymus: Experimental and clinical studies. Ciba Foundation Symposium. Churchill, London, pp 416-439

Strauss AJL, Seegal BC, Hsu KC, Burkholder PM, Nastuk WL, Osserman KE (1960) Immunofluorescence demonstration of a muscle binding, complement-fixing serum globulin fraction in myasthenia gravis. Proc Soc Exp BioI Med 105:184-191

Strauss AJL, Smith ChW, Cage GW, van der Geld HWR, McFarlin DE, Barlow M (1966) Further studies on the specificity of presumed immune associations of my as the­nia gravis and consideration of possible pathogenic implications. Ann NY Acad Sci 135:557-579

Talal N (1976) Disordered immunologic regulation and autoimmunity. Transplant Rev 31:240-263

Tamaoki N, Habu S, Kameya T (1971) Thymic lymphoid follicles in autoimmune disea­ses. II. Histological, histochemical and electron microscopic studies. Keio J Med 20:57-68

Tesseraux H (1959) Physiologie und Pathologie des Thymus unter besonderer Berucksich­tigung der pathologischen Morphologie. In: Zwanglose Abhandlungen aus dem Ge­biete der Inneren Sekretion, Bd 9. Joh. Ambr. Barth, Leipzig

Twomey JJ, Lewis VM, Patten BM, Goldstein G, Good RA (1979) Myathenia gravis, thymectomy and serum thymic hormone activity. Am J Med 66:639-643

Ueno S, Kang J, Takeuchi H, Takahashi M, Tarui S (1980a) Specificities of antibody to acetylcholine rceptor in rabbits with experimental myasthenia gravis. Clin Exp Immunol41: 13-18

Ueno S, Wada K, Takahashi M, Tarui S (1980b) Acetylcholine receptor in rabbit thymus: Antigenic similarity between acetylcholine receptors of muscle and thymus. Clin Exp Immunol 42: 463-469

Valdes-Dapena M (1982) The pathologist and the sudden infant death syndrome. Am J PathoI106:118-131

Van de Velde RL, Friedman NB (1966) The thymic "Myoidzellen" and myasthenia gravis. J Am Med Ass 198:287-288

Van de Velde RL, Friedman NB (1970) Thymic myoid cells and myasthenia gravis. Am J PathoI59:347-368

Van der Geld HWR, Strauss AJL (1966 I) Myasthenia gravis. Immunological relationship between striated muscle and thymus. Lancet 57-60

Vetters M, Barclay RS (1973) The incidence of germinal centers in thymus glands of patients with congenital heart disease. J Clin Pathol 26: 583-591

Vetters JM, Simpson JA (1974) Comparison of thymic histology with response to thymec­tomy in myasthenia gravis. J Neurol Neurosurg Psychiat 37: 1139-1145

Wegelin C (1918) Ueber Lymphfollikel mit Keimzentren im Thymusmark. Zentralbl Allg PathoI29:441-447

Epitheliale Thymustumoren (Thymome) 275

Wiesel J (1912) Pathologie des Thymus. In: Lubarsch 0, Ostertag R (Hrsg) Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie des Menschen und der Tiere. 15. Jahrg, 2. Abt, 1911. JF Bergmann, Wiesbaden, S 416-782

Young M, Turnbull HM (1931) An analysis of the data collected by the status lymphaticus investigation committee. J PathoI34:213-258

Epitheliale Thymustumoren (Thymome)

Adams JE (1963) Leukemogenic thymoma. Report of a unique case. Am J Clin Pathol 40: 173-182

Albertini A v, Roulet FC (1974) Histologische Geschwulstdiagnostik. Systematische Mor­phologie der menschlichen Geschwiilste als Grundlage fiir die klinische Beurteilung, 2. Aufl. Thieme, Stuttgart

Alpert LI, Papatestas A, Kark A, Osserman RS, Osserman K (1971) A histologic reap­praisal of the thymus in myasthenia gravis. A correlative study of thymic pathology and response to thymectomy. Arch Pathol 91: 55-61

Andersen V, Pedersen H (1967) Thymoma and acute leukaemia. Acta Med Scand 182:581-590

Andritsakis GD, Sommers SC (1959) Criteria of thymic cancer and clinical correlations of thymic tumors. J Thorac Surg 37: 273-290

Andrus WDW, Foot NC (1937) Report of a large thymic tumor successfully removed by operation. J Thorac Surg 6: 648-659

Aronson IK, Soltani K, Paik K-I, Rubenstein D, Lorincz AL (1978) Triad of lichen planus, myasthenia gravis, and thymoma. Arch Dermatol114:255-258

Atsmon A, Pinkhas J, Djaldetti M (1962) Sudden death caused by pressure of a thymoma on the right atrium. Arch Intern Med 110:295-298

Barcos MP, Lukes RJ (1975) Malignant lymphoma of convoluted lymphocytes - A new entity of possible T-cell type. In: Sinks LF, Godden JO (eds) Conflicts in Child­hood Cancer. An Evaluation of Current Management. Vol. 4. Alan R. Liss Inc., New York, pp 147-178

Baroni CD, Rigato P, Ruco L, Uccini S, Mineo T, Ricci C (1980) PHA and ConA lymphocyte response in normal, hyperplastic and neoplastic human thymus: Morpho­logic and functional correlations. Cancer 46:2055-2061

Batata MA, Martini N, Huvos AG, Aguilar RI, Beattie EJ (1974) Thymomas: Clinicopa­thologic features, therapy, and prognosis. Cancer 34:389-396

Baud M, Stamenkovic I, Kapanci Y (1981) Malignant Thymomas: Clinicopathologic study of 13 cases. In: Fenoglio CM, Wolff M (eds) Progress in Surgical Pathology, Vol III. Masson Publishing USA, Inc., New York Paris Barcelona Milan Mexico City Rio de Janeiro, pp 129-146

Bell ET (1917) Tumors of the thymus in myasthenia gravis. J Nerv Ment Dis 45: 130-143 Benjamin SP, McCormack LJ, Effier DB, Groves LK (1972) Primary tumors of media­

stinum. Chest 62: 297-303 Berard CW, Dorfman RF (1974) Histopathology of malignant lymphomas. Clin Hematol

3:39-76 Bergh NP, Gatzinsky P, Larsson S, Lundin P, Ridell B (1978) Tumors of the thymus

and thymic region: I. Clinicopathological studies on thymomas. Ann Thorac Surg 25:91-98

Bernatz PhE, Harrison EG, Clagett OTh (1961) Thymoma: A clinicopathologic study. J Thorac Cardiovasc Surg 42: 424-444

Bernatz PhE, Khonsari S, Harrison EG, Taylor WF (1973) Thymoma: Factors influenc­ing prognosis. Surg Clin North Am 53:885-892

Bertelsen S, Malmstron J, Heerfordt J, Pedersen H (1975) Tumors of the thymic region. Thorax 30: 19-25

BettendorfU, Bauer K-H (1981) Thymomdiagnostik unter besonderer Beriicksichtigung der computertomographisch gesteuerten perthorakalen Biopsie. Dtsch Med W 0-

chenschr 106: 84-88

276 Literatur zu Teil 2

Bloodworth JMB, Hiratsuka H, Hickey RC, Wu J (1975) Ultrastructure of the human thymus, thymic tumors, and myasthenia gravis. Pathol Annu 10: 329-391

B6hm W, Strauch G (1962) Zur Morphologie der epithelialen Thymusgeschwiilste. Vir­chows Arch [Pathol Anat] 335: 632-641

B6ttiger LE, Rausing A (1972) Pure red cell anemia, immunosuppressive treatment. Ann Intern Med 76:593-597

Boston B (1976) Chemotherapy of invasive thymoma. Cancer 38:49-52 Burrows S, Carroll R (1971) Thymoma associated with pancytopenia. Arch Pathol

92 :465--468 Butler WM, Diehl LF, Taylor HG, Weltz MD (1981) Metastatic thymoma with mysthenia

gravis. Complete remission with combination chemotherapy. Cancer 50:419-422 Campbell MG, Pollard R, Al-Sarraf M (1981) A complete response in metastatic malig­

nant thymoma to cisplatinum, doxorubicin and cyclophosphamide: A case report. Cancer 48: 1315-1317

Castleman B (1955) Tumors of the thymus gland. In: Atlas of Tumor Pathology. Sec. V, Fasc 19. Armed Forces Institute of Pathology, Washington, DC

Castleman B (1966) The pathology of the thymus gland in myasthenia gravis. Ann NY Acad Sci 135: 496-503

Castleman B, Norris EH (1949) The pathology of the thymus in myasthenia gravis. A study of 35 cases. Medicine 28: 27-58

Chahinian APh, Bhardwaj S, Meyer RJ, Jaffrey IS, Kirschner PA, Holland JF (1981) Treatment of invasive or metastatic thymoma: Report of eleven cases. Cancer 47:1752-1761

Chatten J, Katz SM (1976) Thymoma in a 12-year-old boy. Cancer 37:953-957 Chen KTK (1979) Metastasizing thymoma. Arch Pathol Lab Med 103:153-154 Chopek MW, Rosai J, Levine GD (1976) Malignant thymoma with rhabdomyosarcoma­

tous ("myoid cell") differentiation: Report of a case and review of the literature. Lab. Invest. 34: 343 (Abstr)

Cocconi G, Boni C, Cuomo A (1982) Long-lasting response to cis-platinum in recurrent malignant thymoma. Case report. Cancer 49: 1985-1987

Cooper GN, Narodick BG (1972) Posterior mediastinal thymoma, case report. J Thorac Cardiovasc Surg 63: 561-563

Cossman J, Deegan MJ, Schnitzler B (1978) Thymoma: An immunologic and electron microscopic study. Cancer 41 :2183-2191

Cowan RJ, Maynard CD, Witcofski RL, Janeway R, Toole JF (1971) Selenomethionine Se75 thymus scans in myasthenia gravis. J Am Med Ass 215:978-979

Danisch F, Nedelmann E (1928) B6sartiges Thymom bei einem 31/~ii.hrigen Kind mit eigenartiger Metastasierung ins Zentralnervensystem (Zugleich ein Beitrag zur Klinik und pathologischen Anatomie der Geschwulstmetastasierung auf dem Liquorwege). Virchows Arch [Pathol Anat] 268 :492-514

Dehner LP, Martin SA, Sumner HW (1977) Thymus related tumors and tumor-like lesions in childhood with rapid clinical progression and death. Hum Pathol 8: 53-66

Effler DB, McCormack LJ (1956) Thymic neoplasms. J Thorac Surg 31 :60--82 Ehrenreich Th, Allen AC (1958) Myasthenia gravis following extirpation of an asympto­

matic thymoma. Cancer 11 : 173-180 Ellman P, Hodgson DC (1958) Myasthenia gravis occuring in association with a malig­

nant thymic tumour. Brit Med J 1 : 626-628 Evans WK, Thompson DM, Simpson WJ, Feld R, Phillips MJ (1980) Combination

chemotherapy in invasive thymoma. Role of COPP. Cancer 46: 1523-1527 Ewing J (1916) The thymus and its tumors. Report of three cases of thymoma. Surg

Gynec Obstet 22:461-472 Fechner RE (1969) Recurrence of noninvasive thymomas. Report of four cases and

review of literature. Cancer 23: 1423-1427 Feltkamp CA, van Heerde P, Feltkamp-Vroom ThM, Koudstaal J (1981) A malignant

tumor arising from interdigitating cells; Light microscopical, ultrastructural, immuno­and enzyme-histochemical characteristics. Virchows Arch [Pathol Anat] 393: 183-192

Epitheliale Thymustumoren (Thymome) 277

Fershtand JB, Shaw RR (1951) Malignant tumor of thymus gland, myasthenia gravis developing after removal. Ann Intern Med 34: 1025-1035

Fisher ER (1968) The thymus. In: Bloodworth JMB (ed) Endocrine pathology. The Williams and Wilkins Co, Baltimore, pp 197-219

Frank HA, Reiner L, Fleischner FG (1956) Co-occurrence of large leiomyoma of the esophagus and squamouscell carcinoma of the thymus: Report of a case, with roentge­nologic, pathological and clinical discussion. New Engl J Med 255:159-164

Friedman NB (1967) Tumors of the thymus. J Thorac Cardiovasc Surg 53: 163-182 Geary CG, Byron PR, Taylor G, MacIver JE, Zervas J (1975) Thymoma associated

with pure red cell aplasia, immunoglobulin deficiency and an inhibitor of antigen-induced lymphocyte transformation. Brit J HaematoI29:479--485

Gilbert EF, Harley JB, Anido V, Mengoli HF, Hughes JT (1968) Thymoma, plasma cell myeloma, red cell aplasia and malabsorption syndrome. Am J Med 44: 820-829

Goel Y, Sims J, Pittman JA (1971) Mediastinum scanning with 75Se-selenomethionine. J Nucl Med 12:644-645

Goldstein G, Mackay IR (1969) The human thymus. William Heinemann Medical Books Ltd, London

Gonzalez-Crussi F (1982) Extragonadal teratomas. In: Atlas of Tumor Pathology. Sec. Ser., Fasc. 18. Armed Forces Institute of Pathology, Washington, DC

Good RA (1954) Agammaglobulinaemia: A provocative experiment of nature. Bull Univ Minn Hosp 26: 1-19

Gould ThS, Tanguay PR, DeLellis RA (1977) Thymoma and primary lymphoma of the small intestine. Cancer 40:1755-1758

Grandhomme F (1900) Ueber Tumoren des vorderen Mediastinums und ihre Beziehungen zu der Thymusdruese. Inaug. Diss., Heidelberg. L.C. Wittich'sche Hofbuchdruckerei, Darmstadt

Gravanis MB (1968) Metastasizing thymoma. Report of a case and review of the litera­ture. Am J Clin Pathol 49: 690-696

Gray GF, Gutowski WTh (1979) Thymoma. A clinicopathologic study of 54 cases. Am J Surg Pathol 3: 235-249

Griffin JD, Aisenberg AC, Long JC (1978) Lymphocytic thymoma associated with T-cell lymphocytosis. Am J Med 64: 1075-1079

Guerin RA, Guerin MTh (1966) Tumeurs du thymus. A propos de 12cas irradies par telecobalt-thCrapie. Presse MCd 74: 2875-2881

Guillan RA, Zelman S, Smalley RL, Iglesias PA (1971) Malignant thymoma associated with myasthenia gravis, and evidence of extrathoracic metastases. An analysis of published cases and report of a case. Cancer 27: 823-830

Giirtler K-F, Janzen RWC, Hagemann J, Otto HF (1982) Computertomographie des Mediastinums bei Myasthenia gravis pseudoparalytica. Normalbefund-Thymushyper­plasie-Thymustumoren. Fortschr Rontgenstr 136: 35--40

Hale JF (1968) Tumours of the thymus. Proc Roy Soc Med 61: 871-874 Halpern SR, Schoelzel E, Johnson RB (1966) Thymoma in a young child producing

symptoms of asthma. Am J Dis Child 111 : 99-104 Hasner E, Westengard E (1963) Thymomas. Acta Chir Scand 126:58-65 Hasse W (1968) Die Geschwiilste des Mediastinums im Kindesalter. Langenbecks Arch

Klin Chir 322:1236-1247 Heine J (1949) Uber gutartige spezifische Thymusgewiichse (Thymusreticulome). In: Hol­

thusen H (Hrsg) Aktuelle Probleme der Pathologie und Therapie. Thieme, Stuttgart Hellwig CA (1941) Malignant thymoma. Clinical-pathological study of eight cases. Surg

Gynec Obstet 73:851-863 Henderson DW, Papadimitriou JM (1982) Ultrastructural appearances of tumours. A

diagnostic atlas. Churchill Livingstone, Edinburgh, London, Melbourne, New York Henry K (1972) An unusual thymic tumour with a striated muscle (myoid) component

(with a brief review of the literature on myoid cells). Brit J Dis Chest 66: 291-299 Henry K, Farrer-Brown G (1981) A colour atlas of thymus and lymph node histopathol­

ogy with ultrastructure. Wolfe Medical Publications Ltd, London

278 Literatur zu Teil 2

Higasi T, Nakayama Y, Murata A, Nakamura K, Sugiyama M, Kawaguchi T, Suzuki S (1972) Clinical evaluation of 67Ga-citrate scanning. J Nucl Med 13: 196--201

Hirst E, Robertson TI (1967) The syndrome of thymoma and erythroblastopenic anemia. A review of 56 cases including 3 case reports. Medicine 46: 225-264

Holmes Sellors T, Thackray AC, Thomson AD (1967) Tumours of the thymus. A review of 88 operation cases. Thorax 22: 193-220

Holt S, Deverall PB, Boddy JE (1978) A teratoma of the lung containing thymic tissue. J PathoI126:85-89

Homer MJ, Wechsler RJ, Carter BL (1978) Mediastinal lipomatosis. CT confirmation of a normal variant. Radiology 128: 657-661

Hubbell DS, Liebow AA (1952) Thymic tumors characterized by lymphangioendothelial structure. Am J Pathol 28: 321-345

Iverson L (1956) Thymoma. A review and reclassification. Am J Pathol 32:695-719 Jain U, Frable WJ (1974) Thymoma. Analysis of benign and malignant criteria. J Thorac

Cardiovasc Surg 67: 310-321 Janzen RWCh, Lachenmayer L (1976) Parathymische Syndrome. Dtsch Med Wochenschr

101: 1292-1294 Janzen RWCh, Lachenmayer L (1977) Friih- und Spatsyndrome bei Thymomen. In:

Hertel G, Mertens HG, Ricker K, Schimrigk K (Hrsg) Myasthenia gravis und andere Storungen der neuromuskulaten Synapse. Thieme, Stuttgart, S 132-139

Kameya T, Watanabe Y (1965) Electron microscopic observations on human thymus and thymoma. Acta Pathol Jpn 15:223-246

Katz JH (1953) Malignant thymoma in myasthenia gravis. Report of an unusual case with a brief discussion of the role of the thymus in the disease. New Engl J Med 248: 1059-1064

Kaung DT, Cech RF, Peterson RE(1968) Benign thymoma and erythroid hypoplasia, thirteen-year "cure" following thymectomy. Cancer 22: 445-450

Keller AR, Castleman B (1974) Hodgkin's disease of the thymus gland. Cancer 33:1615-1623

Kilman JW, Klassen PK (1971) Thymoma. Am J Surg 121 :710-711 Kneringer E, Priesel A (1923) Ein Beitrag zur Kenntnis der Thymome (Lymphoepithe­

lioma thymi). Virchows Arch [Pathol AnatJ241 :475-487 Knowles DM (1976) Thymoma and chronic myelogenous leukemia. A case report. Cancer

38:1414-1419 Krantz SB (1974) Pure red-cell aplasia. New Engl J Med 291: 345-350 Krantz SB (1976) Diagnosis and treatment of pure red cell aplasia. Med Clin North

Am 60: 945-958 Krantz SB, Kao V (1967) Studies on red cell aplasia. I. Demonstration of a plasma

inhibitor to heme synthesis and an antibody to erythroblast nuclei. Proc Natl Acad Sci (USA) 58:493-500

Krantz SB, Moore WH, Zaentz SD (1973) Studies on red cell aplasia. V. Presence of erythroblast cytotoxicity in yG-globulin fraction of plasma. J Clin Invest 52: 324-336

Lattes R (1962) Thymoma and other tumors of the thymus. An analysis of 107 cases. Cancer 15: 1224-1260

Lauriola L, Piantelli M, Carbone A, Dina MA, Scoppetta C, Musiani P (1979) Subpopu­lations oflymphocytes in human thymomas. Clin Exp Immunol 37: 502-506

Lauriola L, Maggiano N, Marino M, Carbone A, Piantelli M, Musiani P (1981) Human thymoma: Immunologic characteristics of the lymphocytic component. Cancer 48:1992-1995

Leder L-D (1965) Fermenthistochemische Befunde bei chronischer Erythroblastose und akuter Erythramie. Klin Wochenschr 43:795-796

Legg MA, Brady WJ (1965) Pathology and clinical behavior of thymomas. A survey of 51 cases. Cancer 18:1131-1144

LeGolvan DP, Abell MR (1977) Thymomas. Cancer 39:2142-2157 Lehar ThJ, Heard JL (1970) Agammaglobulinemia and thymoma associated with nonthy­

mic cancer. Cancer 25: 875-879

Epitheliale Thymustumoren (Thymome) 279

Lemos LB, Hamoudi AB (1978) Malignant thymic tumor in an infant (malignant histiocy­toma). Arch Pathol Lab Med 102:84-89

Levasseur Ph, Kaswin R, Rojas-Miranda A, N'Guimbous J-F, Merlier M, LeBrigand H (1976) Profil des tumeurs chirurgicales du mediastin. A propos d'une serie de 742 operes. Nouv Presse Med 5:2857-2859

Levine GD, Bearman RM (1980) The thymus. In: Johannessen JV (ed) Electron Micro­scopy in Human Medicine. Vol 5: Cardiovascular System, Lymphoreticular and He­matopoietic System. McGraw-Hill International Book Comp, New York etc., pp 214-254

Levine GD, Bensch KG (1972) Epithelial nature of spindlecell thymoma. An ultrastructu­ral study. Cancer 30:500-511

Levine GD, Polliack A (1975) The T-cell nature of the lymphocytes in two human epithe­lial thymomas: A comparative immunologic, scanning and transmission electron mi­croscopic study. Clin Immunol Immunopathol4: 199-208

Levine GD, Rosai J (1978) Thymic hyperplasia and neoplasia: A review of current concepts. Hum PathoI9:495-515

Levine GD, Rosai J, Bearman RM, Polliack A (1975) The fine structure of thymoma, with emphasis on its differential diagnosis. Am J Pathol81 :49-86

Lindstrom FD, Williams RC, Brunning RD (1968) Thymoma associated with multiple myeloma. Arch Intern Med 122: 526--531

Livesay 11, Mink JH, Fee HJ, Bein ME, Sample WF, Mulder DG (1979) The use of computed tomography to evaluate suspected mediastinal tumors. Ann Thorac Surg 27:305-311

Llombart-Bosch A (1975) Epithelio-reticular cell thymoma with lymphocytic "emperipo­lesis". An ultrastructural study. Cancer 36:1794-1803

Lowenhaupt E (1948) Tumors of the thymus in relation to the thymic epithelial anlage. Cancer 1: 547-563

Lowenhaupt E, Brown R (1951) Carcinoma of the thymus of granulomatous type. A clinical and pathological study. Cancer 4: 1193-1209

Lukes RJ, Collins RD (1974) Immunologic characterization of human malignant lympho­mas. Cancer 34:1488-1503

Mackey L (1975) Clear-cell thymoma and thymic hyperplasia in a cat. J Comp Pathol 85:367-371

Margolis HM (1931) Tumors of the thymus: Pathology, Classification and report of cases. Am J Cancer 15 [Suppl] 2106--2142

Marks RD, Wallace KM, Pettit HS (1978) Radiation therapy control of nine patients with malignant thymoma. Cancer 41: 117-119

Masaoka A, Nagaoka Y, Maeda M, Monden Y, Seike Y (1977) Study on the ratio of lymphocytes to epithelial cells in thymoma. Cancer 40: 1222-1228

Masaoka A, Monden Y, Nakahara K, Tanioka T (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48: 2485-2492

Matani A, Dritsas C (1973) Familial occurrence of thymoma. Arch Pathol 95: 90-91 McBurney RP, Clagett OT, McDonald JR (1951) Primary intrapulmonary neoplasm

(thymoma?) associated with myasthenia gravis: Report of a case. Mayo Clin Proc 26:345-353

Middleton G (1966) Involvement of the thymus by metastatic neoplasms. Brit J Cancer 20:41--46

Miller JFAP, Dukor P (1964) Die Biologie des Thymus nach dem heutigen Stande der Forschung. Karger, Basel

Min K-W, Waddell CC, Pircher FJ, Granville GE, Gyorkey F (1978) Selective uptake of 75Se-Selenomethionine by thymoma with pure red cell aplasia. Cancer 41: 1323-1328

Minkowitz S, Solomon L, Nicastri AD (1968) Cytologically malignant thymoma with distant metastasis. Cancer 21 : 426--433

Mottet NK (1964) Malignant thymoma. Am J Clin Pathol41 :61-71 Namba T, Brunner NG, Grob D (1978) Myasthenia gravis in patients with thymoma,

with particular reference to onset after thymectomy. Medicine 57:411--433

280 Literatur zu Teil 2

Neale AE, Menten ML (1948) Tumors of the thymus in children. Am 1 Dis Child 76: 102-108

O'Gara RW, Horn RC, Enterline HT (1958) Tumors of the anterior mediastinum. Cancer 11 :562-590

Otto HF (1978) Untersuchungen zur Ultrastruktur lymphoepithe1ialer Thymustumoren unter besonderer Berucksichtigung der sog. "Emperipolesis". Virchows Arch [Pathol Anat] 379: 335-349

Pascoe HR, Miner MS (1976) An ultrastructural study of nine thymomas. Cancer 37:317-326

Pedraza MA (1977) Thymoma immunological and ultrastructural characterization. Can­cer 39:1455-1461

Penn CRH, Hope-Stone HF (1972) The role of radiotherapy in the management of malignant thymoma. Brit 1 Surg 59: 533-539

Peterson RDA, Cooper MD, Good RA (1965) The pathogenesis of immunologic defi­ciency diseases. Am 1 Med 38: 579-604

Pons A, Armand 1-P, Voigt 1-1, Combes P-F (1977) Radiotherapy results in 14 cases of malignant thymomas. Therapeutic prospect. Bull Cancer 54: 79-82

Pope RH, Osgood R (1953) Reticular perithelioma of the thymus. Am 1 Pathol 29: 85-103

Posner MR, Prout MN, Berk S (1980) Thymoma and the nephrotic syndrome. A report of a case. Cancer 45: 387-391

Rachmaninoff N, Fentress V (1964) Thymoma with metastasis to the brain. Am 1 Clin Pathol 41: 618-625

Ridenhour CE, Henzel 1H, DeWeese MS, Kerr SE (1970) Thymoma arising from undes­cended cervical thymus. Surgery 67:614-619

Robins-Browne RM, Green R, Katz 1, Becker D (1977) Thymoma, pure red cell aplasia, pernicious anaemina and candidiasis: a defect in immunohomeostasis. Brit 1 Haematol 36:5-13

Rogers BHG, Manaligod 1R, Blazek WV (1968) Thymoma associated with pancytopenia and hypogammaglobulinemia: Report of a case and review of the literature. Am 1 Med 44: 154-164

Rosai 1 (1981) Mediastinum. In: Rosai 1 (ed) Ackmerman's surgical pathology, Vol I. The C.V. Mosby Comp, St. Louis Toronto London, pp 295-329

Rosai 1, Levine GD (1976) Tumors of the thymus. In: Atlas of tumor pathology. Sec. Ser., Fasc. 13. Armed Forces Institute of Pathology, Washington, DC

Rosen V1, Christiansen TW, Hughes RK (1966) Metastatic thymoma presenting as a solitary pulmonary nodule. Cancer 19: 527-532

Rosenberger A, Adler D (1978) Fine needle aspiration in the diagnosis of mediastinal lesions. Am 1 Roentgenol131 :239-242

Rubin 1W, Ellison RG, Moore HV, Pai GP (1981) Factors affecting response to thymec­tomy for myasthenia gravis. 1 Thorac Cardiovasc Surg 82: 720-728

Salyer WR, Eggleston 1C (1976) Thymoma. A clinical and pathological study of 65 cases. Cancer 37: 229-249

Sawyers 1L, Foster 1H (1968) Surgical treatment of thymomas. Arch Surg 96: 814-817 Schmid 1R, Kiely 1M, Harrison EG, Bayrd ED, Pease GL (1965) Thymoma associated

with pure red cell agenesis: Review of literature and report of 4 cases. Cancer 18:216-230

Schmincke A (1926) Pathologie des Thymus. In: Henke F, Lubarsch 0 (Hrsg) Drusen mit innerer Sekretion. Springer, Berlin (Handbuch der speziellen pathologischen Ana­tomie und Histologie, Bd VIII, S 760-809)

Schumpelick V, 1anzen RWC, Lachenmayer L, Gurtler KF, Otto HF, Schontag G (1982) Thymektomie bei Myasthenia gravis. Indikation-Technik-Ergebnisse. Akt Chir 17: 175-182

Seybold WD, McDonald 1R, Clagett OT, Good CA (1950) Tumors of the thymus. 1 Thorac Surg 20:195-215

Shimosato Y, Kameya T, Nagai K, Suemasu K (1977) Squamous cell carcinoma of the thymus. An analysis of eight cases. Am 1 Surg Patholl: 109-121

Epitheliale Thymustumoren (Thymome) 281

Shirai T, Miyata M, Nakase A, !toh T (1976) Lymphocyte subpopulation in neoplastic and non-neoplastic thymus and in blood of patients with myasthenia gravis. Clin Exp ImmunoI26:118-123

Silverman NA, Sabiston DC (1980) Mediastinal masses. Surg Clin North Am 60:757-777 Simmonds M (1913) Uber maligne Thymusgeschwiilste. Z Krebsforsch 12:280-285 Skinnider LF, Alexander S, Horsman D (1982) Concurrent thymoma and lymphoma:

A report of two cases. Hum Pathol13:163-166 Slater G, Papatestas AE, Genkins G, Kornfeld P, Horowitz StH, Bender A (1978) Thy­

moma in patients with myasthenia gravis. Ann Surg 188: 171-174 Smith WF, DeWall RA, Krumholz RA (1970) Giant thymoma. Chest 58:383-385 Snover DC, Levine GD, Rosai J (1982) Thymic carcinoma. Five distinctive histological

variants. Am J Surg PathoI6:451-470 Souadjian JV, Silverstein MN, Titus JL (1968) Thymoma and cancer. Cancer

22: 1221-1225 Souadjian JV, Enriquez P, Silverstein MN, Pepin J-M (1974) The spectrum of diseases

associated with thymoma. Coincidence or syndrome? Arch Intern Med 134: 374-379 Stein H, Staudinger M, Tolksdorf G, Lennert K (1981) Immunologic markers in the

differential diagnosis of non-Hodgkin's lymphomas. J Cancer Res Clin Oncol 101:29-42

Sternberg C (1916) Leukosarkomatose und Myeloblastenleukiimie. Beitr Pathol Anat 61:75-100

Sundstrom C (1976) Thymoma in a case of scleroderma. Acta Pathol Microbiol Scand Sect A 84:317-321

Symmers D (1932) Malignant tumors and tumor-like growths of the thymic region. Ann Surg 95:544-572

Talerman A, Amigo A (1968) Thymoma associated with aregenerative and aplastic an­emia in a five-year-old child. Cancer 21: 1212-1218

Thomson AD (1955) The thymic origin of Hodgkin's disease. Brit J Cancer 9:37-50 Thomson AD, Thackray AC (1957) The histology of tumours of the thymus. Brit J

Cancer 11: 348-357 Toker C (1968) Thymoma. An ultrastructural study. Cancer 21: 1157-1163 Vessey MP, Doll R (1972) Thymectomy and cancer - a followup study. Brit J Cancer

26:53-58 Wadon A (1934) Thymoma intratracheale. Zentralbl Allg PathoI60:308-312 Waldmann TA, Strober W, Blaese RM, Strauss AJL (1967) Thymoma, hypogammaglo­

bulinemia and absence of eosinophils. J Clin Invest 46: 1127-1128 Walther E (1980) Das Thymom: therapeutische und prognostische Aspekte. Schweiz

Med Wochenschr 110:1764-1771 Wasserman P, Epstein JW (1939) Congenital carcinoma of the thymus with extensive

generalized metastases. J Pediatr 14: 798-804 Watanabe H (1966) A pathological study of thymomas. Acta Pathol Jpn 16: 323-358 Watanabe H (1971) Thymoma and thymic germinal center. Keio J Med 20:69-75 Weissberg D, Goldberg M, Pearson FG (1973) Thymoma. Ann Thorac Surg 16:141-147 Wekerle H, Hohlfeld R, Ketelsen U-P, Kalden JR, Kalies I (1981) Thymic myogenesis,

T -lymphocytes and the pathogenesis of myasthenia gravis. Ann NY Acad Sci 377:455-475

Whitaker JA, Vogler WR, Werner JH (1970) Red cell aplasia and osteoblastic metastases in a patient with thymoma. Cancer 26: 427-435

Wick MR, Nichols WC, Ingle IN, Bruckman JE, Okazaki H (1981) Malignant, predomi­nantly lymphocytic thymoma with central and peripheral nervous system metastases. Cancer 47: 2036-2043

Wick MR, Weiland LH, Scheithauer BW, Bernatz PhE (1982) Primary thymic carcino­mas. Am J Surg Pathol 6: 613-630

Wilkins EW, Castleman B (1979) Thymoma: A continuing survey at the Massachusetts General Hospital. Ann Thorac Surg 28: 252-255

Wilkins EW, Edmunds LH, Castleman B (1966) Cases of thymoma at the Massachusetts General Hospital. J Thorac Cardiovasc Surg 52: 322-330

282 Literatur zu Teil2

Willnow U; Tischer W (1973) Thymusgeschwiilste 1m Kindesalter. Zentralbl Chir 98:581-589

Yeoh CB, Ford JM, Lattes R, Wyle RH (1966) Intrapulmonary thymoma. J Thorac Cardiovasc Surg 51: 131-136

Zeok JV, Todd EP, Dillon M, DeSimone P, Utley JR (1979) The role of thymectomy in red cell aplasia. Ann Thorac Surg 28: 257-260

Thymus-Karzinoide

Bernatz PhE, Harrison EG, Clagett OTh (1961) Thymoma: A clinicopathologic study. J. Thorac. Carciovasc. Surg 42:424-444

Bernatz PhE, Khonsari S, Harrison EG, Taylor WF (1973) Thymoma: Factors influen­cing prognosis. Surg Clin North Am 53: 885-892

Bolande RP (1974) The neurocristopathies. A unifying concept of disease arising in neural crest maldevelopment. Hum PathoI5:409--429

Chalk S, Donald KJ (1977) Carcinoid tumour of the thymus. A case report including discussion of the morphological diagnosis and the cell of origin. Virchows Arch [pa­thol Anat] 377:91-96

Cohen RB, Toll GD, Castleman B (1960) Bronchial adenomas in Cushing's syndrome: their relation to thymomas and oat cell carcinomas associatd with hyperadrenocorti­cism. Cancer 13:812-817

DeLellis RA, Wolfe HJ (1976) Calcitonin in spindle cell thymic carcinoid tumors. Arch Pathol Lab Med 100:340

Dry J, Pradalier A, Herman D, Leynadier F (1976) La polyadenomatose endocrinienne avec tumeur carcinoide. Sem Hop (Paris) 52: 1691-1695

Duguid JB,Kennedy AM (1930) Oat-cell tumours of mediastinaiglands. J Pathol Bact 33:93-99

FetissofF, Boivin F, Jobard P,Arbeille-Brassatt B, Romet JL, Maillet M (1982) Microfi­lamentous carcinoid of the thymus: Correlation of ultrastructural study with Grime­lius stain. UltrastructPathoI3:9-15

Fisher ER (1964) Pathology of the thymus and its relation to human disease. In: Good RA, Gabrielsen AE (eds) The thymus in immunobiology. Structure, function, and role in disease. Hoeber Medical Division, Harper and Row Publishers, New York

. Evanston London, pp 67fr-726 Fishman ML, Rosenthal S (1976) Optic nerve metastasis from a mediastinal carcinoid

tumour. Brit J Ophthalmol 60: 583-688 Heitz PhU, Steiner H (1981) Pluriglanduliire endokrine Regulationsstorungen. In: Doerr

W, Seifert G (Hrsg) Spezielle pathologische Anatomie, Bd 14/11, S 1137-1203. Sprin­ger, Berlin Heidelberg New York

Heitz PhU, Kloppel G, Polak JM, Staub J-J (1981) Ectopic hormone production by endocrine tumors: Localization of hormones at the cellular level by immunocyto­chemistry. Cancer 48: 2029-2037

Ho FCS, Ho JCI (1977) Pigmented carcinoid tumour of the thymus. Histopathology 1:363-369

Hosoda S, Suzuki H, Kito H, Hiai H, Akamine Y, Murakami M, Kosukegawa K, Kato N, Yura J, Miyachi Y (1975) Argyrophilic thymic carcinoid. Clinicopathologic study of four cases. Acta Pathol Jpn 25:717-740

Hughes JP, Ancalmo N, Leonard GL, Ochsner JL (1975) Carcinoid tumor of the thymus gland: Report of a case. Thorax 30: 470--475

Judge DM, Changaris DG, Harvey HR, Trapukdi S (1976) Malignant APUDoma (carci­noid) of the anterior mediastinum. Simplified methods of demonstrating biogenic amines in endocrine neoplasms. Arch Pathol Lab Med 100:491--494

Kaneko H, Ishikawa S, Sumida T, Sekiya M, Toshima M, Kobayashi H, Naka Y (1980) Ultrastructural studies of a thymic carcinoid tumor. Acta Pathol Jpn 30:651-658

Kay S, Willson MA (1970) Ultrastructural studies of an ACTH-secreting thymic tumour. Cancer 26: 445--452

Thymus-Karzinoide 283

Kloppel G (1981) Paraganglien. In: Doerr W, Seifert G (Hrsg) Spezielle pathologische Anatomie, Bd 14/11, S 1049-1077. Springer, Berlin Heidelberg New York

Lack EE, Cubilla AL, Woodruff JM (1979) Paragangliomas of the head and neck region. A pathologic study of tumors from 71 patients. Hum Patholl0: 191-218

Levine GD, Rosai J (1976) A spindle cell variant of thymic carcinoid tumor. A clinical, histologic, and fine structural study with emphasis on its distinction from spindle cell thymoma. Arch Pathol Lab Med 100:293-300

Levine GD, Rosai J (1978) Thymic hyperplasia and neoplasia: A review of current concepts. Hum PathoI9:495-515

Lokich JJ, Li F (1978) Carcinoid of the thymus with hereditary hyperparathyroidism. Ann Intern Med 89: 364-365

Lowenthal RM, Gumpel JM, Kreel L, McLaughlin JE, Skeggs DBL (1974) Carcinoid tumour of the thymus with systemic manifestations: A radiological and pathological study. Thorax 29:553-558

Macadam RF, Vetters JM (1969) Fine structural evidence for hormone secretion by a human thymic tumour. J Clin PathoI22:407-409

Manes JL, Taylor HB (1973) Thymic carcinoid in familial multiple endocrine adenomato­sis. Arch Pathol 95: 252-255

Marchevsky AM, Dikman StH (1979) Mediastinal carcinoid with an incomplete Sipple's syndrome. Cancer 43: 2497-2501

Otto HF (1978) Klinisch-pathologische Studie zur Klassifikation und Prognose von 57 Thymustumoren. 2. Prognostische Kriterien. Z Krebsforsch 91 : 103-115

Otto HF (1980) Zur histologischen Klassifikation der primiir thymischen Geschwiilste. Pathologe 1: 131-141

Otto HF (1982) Zur Klassifikation und Prognose mediastinaler Tumoren. Arzt u Kran­kenhaus55:246-252

Otto HF, Hiisselmann H (1976) Thymus-Carcinoid. Fallbericht und Literaturiibersicht. Z Krebsforsch 88: 55-67

Otto HF, Hiisselmann H, Gebbers J-O (1977) Thymus-Carcinoide. Ultrastrukturelle und histochemische Untersuchungen. Verh Dtsch Ges Pathol61: 122-126

Pearse AGE (1974) The APUD cell concept and its implications in pathology. Pathol Annu 9:27-41

Pearse AGE (1977) Das diffuse endokrine (parakrine) System: Feyrter's Konzept und seine moderne Geschichte. Verh Dtsch Ges Pathol 61 : 2-6

Pimstone BL, Uys CJ, Vogelpoel L (1972) Studies in a case of Cushing's syndrome due to an ACTH-producing thymic tumour. Am J Med 53:521-528

Ranchod M, Levine GD (1980) Spindle-cell carcinoid tumors of the lung. A clinicopatho­logic study of 35 cases. Am J Surg Pathol4: 315-331

Rao U, Takita H (1977) Carcinoid tumour of possible thymic origin: Case report. Thorax 32:771-776

Rosai J, Higa E (1972) Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid tumor. Cancer 29: 1061-1074

Rosai J, Levine GD (1976) Tumors of the thymus. In: Atlas of tumor pathology, Sec. Ser., Fasc. 13. Armed Forces Institute of Pathology, Washington, DC

Rosai J, Higa E, Davie J (1972) Mediastinal endocrine neoplasm in patients with multiple endocrine adenomatosis. A previously unrecognized association. Cancer 29: 1075-1083

Rosai J, Levine G, Weber WR, Higa E (1976) Carcinoid tumors and oat cell carcinomas of the thymus. Pathol Annu 11 :201-226

Salyer WR, Salyer DC, Eggleston JC (1976) Carcinoid tumors of the thymus. Cancer 37:958-973

Scholz DA, Bahn RC (1959) Thymic tumors associated with Cushing's syndrome: Review of three cases. Mayo Clin Proc 34:433-441

Stewart CA, Kingston CW (1980) Carcinoid tumour of the thymus with Cushing's syn­drome. Pathology 12:487-494

Sundstrom C, Wilander E (1976) Thymic carcinoid. A case report. Acta Pathol Microbiol Scand Sect A 84:311-316

284 Literatur zu Teil 2

Tanaka T, Tanaka S, Kimura H, Ito J (1974) Mediastinal tumor of thymic origin and related to carcinoid tumor. Acta Pathol Jpn 24:413-426

Wick MR, Scheithauer BW (1982) Oat-cell carcinoma of the thymus. Cancer 49: 1652-1657

Wick MR, Scott RE, Li C-Y, Carney JA (1980) Carcinoid tumor of the thymus. A clinicopathologic report of seven cases with a review of the literature. Mayo Clin Proc 55: 246-254

Wick MR, Bernatz PhE, Carney JA, Brown LR (1982) Primary mediastinal carcinoid tumors. Am J Surg Pathol 6: 195-205

Mesenchymale Thymustumoren

Allen PhW (1981) Tumors and proliferations of adipose tissue. A clinicopathologic ap­proach. Masson Publishing USA Inc. New York Paris Barcelona Milan Mexico City Rio de Janeiro

Almog Ch, Weissberg D, Herczeg E, Pajewski M (1977) Thymolipoma simulating cardio­megaly: a clinicopathological rarity. Thorax 32: 116-120

Barnes RDS, O'Gorman P (1962) Two cases of aplastic anaemia associated with tumors of the thymus. J Clin Pathol 15: 264-268

Benton C, Gerard P (1966) Thymolipoma in a patient with Graves' disease. Case report and review of the literature. J Thorac Cardiovasc Surg 51 :428-433

Bigelow NH, Ehler AA (1952) Lipothymoma: An unusual benign tumor of the thymus gland. J Thorac Surg 23: 528-538

Boetsch CH, Swoyer GB, Adams A, Walker JH (1966) Lipothymoma. Report of two cases. Dis Chest 50: 539-543

Bohut V, Bohutova J, Kolar J (1980) Idiopathische fibrose Mediastinitis mit Hilus­und Lungenbefall (Langfristige Verlaufsbeobachtung). Fortschr Rontgenstr 132: 463-465

Chen W, Chan CW, Mok CK (1982) Malignant fibrous histiocytoma of the mediastinum. Cancer 50: 797-800

Chopek MW, Rosai J, Levine GD (1976) Malignant thymoma with rhabdomyosarcoma­tous ("myoid cell") differentiation: Report of a case and review of the literature. Lab Invest 34: 343 (Abstr)

Doerr W (1974) Thymus. In: Doerr W (Hrsg) Organpathologie, Bd III, S 12-1-12-8. Stuttgart: Thieme

Dunn BH, Frkovich G (1956) Lipomas of the thymus gland. Am J PathoI32:41-51 Feltkamp CA, Heerde P van, Feltkamp-Vroom ThM, Koudstaal J (1981) A malignant

tumor arising from interdigitating cells; Light microscopical, ultrastructural, immuno­and enzyme-histochemical characteristics. Virchows Arch [Pathol Anat] 393: 183-192

Friedman NB (1967) Tumors of the thymus. J Thorac Cardiovasc Surg 53: 163-182 Gurtler K-F, Janzen RWC, Hagemann J, Otto HF (1982) Computertomographie des

Mediastinums bei Myasthenia gravis pseudoparalytica. Fortschr Rontgenstr 136:35-40

Hall GFM (1948) A case of thymolipoma with observations on a possible relationship to intrathoracic lipomata. Brit J Surg 36: 321-324

Harris M (1981) Differential diagnosis of spindle cell tumours by electron microscopy - personal experience and a review. Histopathology 5: 81-105

Hashimoto H, Enjoji M (1981) Recurrent malignant fibrous histiocytoma. A histologic analysis of 50 cases. Am J Surg Pathol 5: 753-760

Henry K (1972) An unusual thymic tumour with a striated muscle (myoid) component (with a brief review of the literature on myoid cells). Brit J Dis Chest 66:291-299

Henry K (1981) The human thymus in disease with particular emphasis on thymitis and thymoma. In: Kendall MD (ed) The thymus gland. The Anatomical Society of Great Britain and Ireland Symposium No. 1. Academic Press, London New York Toronto Sydney San Francisco, pp 85-111

Hernandez FJ, Fernandez BB (1974) Localized fibrous tumors of pleura: A light and electron microscopic study. Cancer 34: 1667-1674

Mesenchymale Thymustumoren 285

Homer MJ, Wechsler RJ, Carter BL (1978) Mediastinal lipomatosis. CT confirmation of a normal variant. Radiology 128: 657-661

Kim H, Pangalis GA, Payne BC, Kadin ME, Rappaport H (1982) Ultrastructural identifi­cation of neoplastic histiocytes-monocytes. Am J PathoI106:204--223

Korhonen LK, Laustela E (1968) Thymolipoma. Scand J Thorac Cardiovasc Surg 2:147-150

Lange I (1916) Ueber ein Lipom des Thymus. Zentralbl AUg PathoI27:97-101 Lemos LB, Hamoudi AB (1978) Malignant thymic tumor in an infant (malignant histiocy­

toma). Arch Pathol Lab Med 102:84--89 Light AM (1978) Idiopathic fibrosis of mediastinum: a discussion of three cases and

review of the literature. J Clin Pathol 31: 78-88 Mathey J, Renaud P (1962) Concerning 61 cases of thymic surgery. Nouv Presse Med

47:2191-2193 Mendez G, Isikoff MB, Isikoff SK, Sinner WN (1979) Fatty tumors of the thorax demon­

strated by CT. Am J Roentgenol133:207-212 Moigneteau C, Cornet E, Gordeef A, Dubigeon P, Delajarte A, Guillement JM (1967)

Le thymo-lipome. J Chir (Paris) 94:509-520 Otto HF, Loning Th, Lachenmayer L, Janzen RWCh, Gurtler KF, Fischer K (1982)

Thymolipoma in association with myasthenia gravis. Cancer 50: 1623-1628 Pachter MR, Lattes R (1963a) Mesenchymal tumors of the mediastinum. I. Tumors

of fibrous tissue, adipose tissue, smooth muscle, and striated muscle. Cancer 16:74--94

Pachter MR, Lattes R (1963b) Mesenchymal tumors of the mediastinum. II. Tumors of blood vascular origin. Cancer 16: 95-107

Pachter MR, Lattes R (1963c) Mesenchymal tumors of the mediastinum. III. Tumors of lymph vascular origin. Cancer 16: 108-117

Politis J, Funahashi A, Gehlsen JA, DeCock D, Stengel BF, Choi H (1979) Intrathoracic lipomas. J Thorac Cardiovasc Surg 77: 55~556

Prohm P, Winter J, Ulatowski L (1981) Liposarcoma of the mediastinum. Case report and review of the literature. Thorac Cardiovasc Surg 29: 119-121

Reintgen D, Fetter BF, Roses A, McCarty KS (1978) Thymolipoma in association with myasthenia gravis. Arch Pathol Lab Med 102:463-466

Ringe B, Dragojevic D, Frank G, Borst HG (1979) Thymolipoma - A rare, benign tumor of the thymus gland. Two case reports and review of the literature. Thorac Cardiovasc Surg 27:369-374

Ringertz N, Lidholm SO (1956) Mediastinal tumors and cysts. J Thorac Surg 31 :458-487 Rosai J, Levine GD (1976) Tumors of the thymus. In: Atlas of tumor pathology, Sec.

Ser., Fasc. 13. Armed Forces Institute of Pathology, Washington, DC RoseffI, Levine B, Gilbert L (1958) Lipothymoma simulating cardiomegaly: Case report.

Am Heart J 56: 119-125 Rubaschow S (1911) Eine bosartige Thymusgeschwulst. Virchows Arch [pathol Anat]

206:141-157 Rubin M, Mishkin S (1954) The relationship between mediastinal lipomas and the thy­

mus. J Thorac Surg 27:494--502 Schmincke A (1926) Pathologie des Thymus. In: Henke F, Lubarsch 0 (Hrsg) Drusen

mit innerer Sekretion. Springer, Berlin (Handbuch der spezieUen pathologischen Ana­tomie und Histologie, Bd VIII, S 76~809)

Schowengerdt CG, Suyemoto R, Main FB (1969) Granulomatous and fibrous mediastini­tis. A review and analysis of 180 cases. J Thorac Cardiovasc Surg 57:365-379

Snover DC, Levine GD, Rosai J (1982) Thymic carcinoma. Five distinctive histological variants. Am J Surg PathoI6:451-470

Teplick JG, Nedwich A, Haskin ME (1973) Roentgenographic features of thymolipoma. Am J Roentgenol117: 873-877

Tesseraux H (1959) Physiologie und Pathologie des Thymus. In: Zwanglose Abhand­lungen aus dem Gebiet der inneren Sekretion, Bd 9. Joh. Ambros. Barth, Leipzig

Trites AEW (1966) Thyrolipoma, thymolipoma and pharyngeal lipoma: A syndrome. Can Med Assoc J 95:1254--1259

286 Literatur zu Teil2

Triiber E, Sadony V, Donhuijsen K (1979) Mediastinales Lipom: Ein diagnostisches Problem? Fortschr Rontgenstr 130:617-619

Wassner UJ (1970) Mediastinalgeschwiilste. Hiiufigkeit, Klinik, Gestalt und Charakter. Schattauer, Stuttgart New York

Weiss SW, Enzinger FM (1978) Malignant fibrous histiocytoma. An analysis of 200 cases. Cancer 41 : 2250-2266

Whittaker LD, Lynn HB (1973) Mediastinal tumors and cysts in the pediatric patients. Surg Clin North Am 53:893-904

Yamanoi S (1921) Zur Lehre der Thymuslipome. Zentralbl Clin 48:785-787

Tumorartige Thymus-Lasionen

Bailey LL, Lynn Hilde R, Smith TR, Thompson RJ (1977) Cervico-mediastinal thymic cyst with vocal cord paralysis. Cancer 39:347-349

Baron RL, Sagel StS, Baglan RJ (1981) Thymic cysts following radiation therapy for Hodgkin disease. Radiology 141: 593-597

Behring C, Bergman F (1963) Thymic cyst of the neck. Acta Pathol Microbiol Scand 59:45-50

Bieger RC, McAdams AJ (1966) Thymic cysts. Arch Pathol 82: 535-541 Breckler lA, Johnston DG (1956) Choristoma of the thymus. Am J Dis Child 92: 175-178 Cote R, Fortin C (1961) Thymic cysts of the neck. Can J Surg 4: 566-569 Duprez A, Cordier R, Schmitz P (1962) Tuberculoma of the thymus. First case of surgical

excision. J Thorac Cardiovasc Surg 44: 115-120 Dyer NH (1967) Cystic thymomas and thymic cysts. Thorax 22:408-421 Ewing J (1940) Neoplastic diseases, 4th ed. Saunders, Philadelphia, p 1000 Fahmy S (1974) Cervical thymic cysts: their pathogenesis and relationship to branchial

cysts. J Laryngol Otol 88: 47-60 Fielding JF, Farmer A W, Lindsay WK, Conen PE (1963) Cystic degeneration in persistent

cervical thymus: A report of four cases in children. Can J Surg 6: 178-186 Froboese C (1969) Mediastinum. In: Doerr W, Seifert G, Uehlinger E (Hrsg) Spezielle

pathologische Anatomie, Bd 4, S 431-634. Springer, Berlin Heidelberg New York Furuya S, Baba S (1971) Cervical thymic cysts and parathyroid cysts. Keio J Med

20: 103-114 Gaeckle DJ, Gerber ML (1962) Thymic cyst of the neck. Am J Surg 103:755-757 Gilmour JR (1941) Some developmental abnormalities of the thymus and parathyroids.

J Pathol Bact 52:213-218 Giraud G, Negre E, Thevenet A, Beraud P (1963) Kyste hydatique du thymus. Presse

Med 71: 1375-1376 Herlitzka AJ, Gale JW (1958) Tumors and cysts of the mediastinum. AMA Arch Surg

76:697-706 Hyde TL, Sellers ED, Owen M (1944) Thymic cyst of the neck. Texas State J Med

39:539-540 Indeglia RA, Shea MA, Grage TB (1967) Congenital cysts of the thymus gland. AMA

Arch Surg 94:149-152 Kopac Z (1939) Beitrag zur Kenntnis des Thymus cysticus bei Erwachsenen. Beitr Pathol

Anat 102:560-572 Krech WG, Storey CF, Umiker WC (1954) Thymic cysts: Review of the literature and

report of two cases. J Thorac Surg 27: 477-493 Lamesch A, Capesius C, Theisen-Aspesberro MC (1974) Cervical thymic cysts in infants

and children. Z Kinderchir 14:213-219 Ribbert H (1912) Die Entwicklungsstorung der Thymusdriise bei kongenitaler Lues.

Frankf Z Path 11 :209-218 Ringertz N, Lidholm SO (1956) Mediastinal tumors and cysts. J Thorac Surg 31 :458-487 Schambacher A (1903) Uber die Persistenz von Driisenkaniilen in der Thymus und ihre

Beziehung zur Entstehung der Hassallschen Korperchen. Virchows Arch [pathol Anat] 172:368-394

Differentialdiagnostisch wichtige Mediastinaltumoren und tumorartige Liisionen 287

Shier KJ (1981) The thymus according to Schambacher: Medullary ducts and reticular epithelium of thymus and thymomas. Cancer 48: 1183-1199

Sieger L, Higgins RG, Adelsberg S van, Isaacs H (1974) Acute thymic hemorrhage. An unusual cause of respiratory distress in infancy. Am J Dis Child 128: 86-87

Simmonds M (1908) Die Thymus bei kongenitaler Syphilis. Virchows Arch [Pathol Anat] 194 (Beiheft): 213-224

Speer FD (1938) Thymic cysts: Report of a thymus presenting cysts of three types. NY Med ColI Flower Hosp Bull 1: 142-150

Tesseraux H (1959) Physiologie und Pathologie des Thymus. In: Zwanglose Abhand­lungen aus dem Gebiet der inneren Sekretion, Bd 9. Joh. Ambros. Barth, Leipzig

Weller RW, Pearce AE, Rapoport M (1951) Thymic cyst of the neck. Arch Pathol 52:569-573

Whittaker LD, Lynn HB (1973) Mediastinal tumors and cysts in the pediatric patient. Surg Clin North Am 53: 893-904

Woolley MM, Isaacs H, Lindesmith G, Wollmer DM, Adelsberg S van (1974) Sponta­neous thymic hemorrhage in the neonate: Report of two cases. J Pediatr Surg 9:231-233

Differentialdiagnostisch wichtige Mediastinaltumoren und tumorartige Liisionen

Abel H, Mall W, Zieger G, Kruger R, Volkmer I (1980) Das Castleman-Lymphom. Angiofollikuliire Lymphknotenhyperplasie als diagnostisches und therapeutisches Problem. Dtsch Med Wochenschr 105: 1536-1541

Albrich W, Schmid KO, Friehs G, KOle W, Seewann HL (1973) Das Castleman-Lym­phom. Virchows Arch [Pathol Anat] 358: 163-171

Banerjee D, Silva E (1981) Mediastinal mass with acute leukemia. Myeloblastoma mas­querading as lymphoblastic lymphoma. Arch Pathol Lab Med 105: 126-129

Barcos MP, Lukes RJ (1975) Malignant lymphoma of convoluted lymphocytes - A new entity of possible T-cell type. In: Sinks LF, Godden JO (eds) Conflicts in child­hood cancer. An evaluation of current management. Vol 4. Alan R. Liss Inc, New York, pp 147-178

Bartoli E, Massarelli G, Soggia G, Tanda F (1980) Multicentric giant lymph node hyper­plasia. A hyperimmune syndrome with a rapidly progressive course. Am J Clin Pathol 73:423--426

Battaglia S, Barbolini G, Botticelli AR (1981) Thymoma mimicking Hodgkin's disease of the thymus. Pathol Res Pract 172: 205-210

Berard CW, Dorfman RF (1974) Histopathology of malignant lymphomas. Clin Hematol 3:39-76

Bergh NP, Gatzinsky, P, Larsson S, Lundin P, Ridell B (1978a) Tumors of the thymus and thymic region: II. Clinicopathological studies on Hodgkin's disease of the thymus. Ann Thorac Surg 25: 99-106

Bergh NP, Gatzinsky P, Larsson S, Lundin P, Ridell B (1978b) Tumors of the thymus and thymic region: III. Clinicopathological studies on teratomas and tumors of germ cell type. Ann Thorac Surg 25:107-111

Buerki H, Locher GW, Graepel P, Ruchti Ch, Brun del Re G, Hess MW (1977) Humoral antibodies against spermatopoietic cells associated with mediastinal germinoma. J PathoI121:183-186

Bush SE, Martinez A, Bagshaw MA (1981) Primary mediastinal seminoma. Cancer 48:1877-1882

Canty TG, Siemens R (1978) Malignant mediastinal teratoma in a 15-year-old girl. Cancer 41: 1623-1626

Carter D, Bibro MC, Touloukian RJ (1982) Benign clinical behavior of immature media­stinal teratoma in infancy and childhood: Report of two cases and review of the literature. Cancer 49: 398--402

Castleman B (1955) Tumors of the thymus gland. In: Atlas of tumor pathology. Sec V, Fasc. 19. Armed Forces Institute of Pathology, Washington DC

288 Literatur zu Teil 2

Castleman B, Towne VW (1954) Case records of the Massachusetts General Hospital. Case 40011 [Hyperplasia of mediastinal lymph nodes]. New Engl J Med 250:26-30

Castleman B, Iverson L, Menendez VP (1956) Localized mediastinal lymph-node hyper­plasia resembling thymoma. Cancer 9: 822-830

Couch WD (1980) Giant lymph node hyperplasia associated with thrombotic thrombocy­topenic purpura. Am J Clin Pathol 74:340-344

Cox JD (1975) Primary malignant germinal tumors of the mediastinum. Cancer 36: 1162-1168

Crane AR, Carrigan PT (1953) Primary subpleural intrapulmonic thymoma. J Thorac Surg 25: 600-605

Diamond LW, Braylan RC (1980) Immunological markers and DNA content in a case of giant lymph node hyperplasia (Castleman's disease). Cancer 46:730-735

Dorfman RF, Warnke R (1974) Lymphadenopathy simulating the malignant lymphomas. Hum PathoI5:519-550

Dura WT, Mioduszewska 0, Porwit-Ksiazek A (1981) Cytoplasmic immunoglobulins in giant lymph node hyperplasia (Castleman's tumour). Virchows Arch [Cell Pathol] 38:239-246

Emson HE (1973) Extrathoracic angiofollicular lymphoid hyperplasia with coincidental myasthenia gravis. Cancer 31 :241-245

Ewing J (1916) The thymus and its tumors. Report of three cases of thymoma. Surg Gynec Obstet 22:461--472

Fechner RE (1969) Hodgkin's disease of the thymus. Cancer 23: 16-23 Fisher ER, Sieracki JC, Goldenberg DM (1970) Identity and nature of isolated lymphoid

tumors (so-called nodal hyperplasia, hamartoma, and angiomatous hamartoma) as revealed by histologic, electron microscopic, and heterotransplantation studies. Cancer 25: 1286-1300

Flendrig JA (1969) Het benigne reuzenlymfoom (the benign giant lymphoma). Proef­schrift, Katholieke Universiteit te Nijmegen. N.V. Drukkerij Helmond, Helmond, The Netherlands

Forsee JH, Farinacci CJ, Blake HA (1953) Ectopia of primary thymic tumors. Ann Surg 138: 922-924

Friedman NB, Velde RL Van de (1981) Germ cell tumors in man, pleiotropic mice, and continuity of germplasm and somatoplasm. Hum Pathol12: 772-776

Frizzera G, Rosai J, Banks PM, Bayrd ED, Massarelli G (1980) A multicentric lympho­proliferative disorder with the morphologic features of Castleman's disease: A clinico­pathologic study of ten patients. Lab Invest 42: 118 (Abstr.)

Gaba AR, Stein RS, Sweet DL, Variakojis D (1978) Multicentric giant lymph node hyperplasia. Am J Clin Pathol 69: 86-90

Geary CG, Fox H (1978) Giant lymph node hyperplasia of the mediastinum and refrac­tory anaemia. J Clin Pathol31 :757-760

Gonzalez-Crussi F (1982) Extragonadal teratomas. In: Atlas of tumor pathology. Sec. Ser., Fasc. 18. Armed Forces Institute of Pathology, Washington, DC

Harrison EG, Bernatz PhE (1963) Angiofollicular mediastinal lymph-node hyperplasia resembling thymoma. Arch Pathol 75: 284-292

Henderson DW, Papadimitriou JM (1982) Ultrastructural appearances of tumours. A diagnostic atlas. Churchill Livingstone, Edinburgh London Melbourne New York

Hurt RD, Bruckman JE, Farrow GM, Bernatz PhE, Hahn RG, Earle JD (1982) Primary anterior mediastinal seminoma. Cancer 49: 1658-1663

Irie T, Watanabe H, Kawaoi A, Takeuchi J (1982) Alpha-fetoprotein (AFP), human chorionic gonadotropin (RCG), and carcinoembryonic antigen (CEA) demonstrated in the immature glands of mediastinal teratocarcinoma. A case report. Cancer 50: 1160-1165

Karcher DS, Pearson CE, Butler WM, Hurwitz MA, Cassell PF (1982) Giant lymph node hyperplasia involving the thymus with associated nephrotic syndrome and mye­lofibrosis. Am J Clin Pathol 77: 100-104

Keller AR, Castleman B (1974) Hodgkin's disease of the thymus gland. Cancer 33:1615-1623

Differentialdiagnostisch wichtige Mediastinaltumoren und tumorartige Lasionen 289

Keller AR, Hochholzer L, Castleman B (1972) Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 29:670--683

Kitzis M, Weiss AM, Michel F, Giul R, Nussaume 0, Monteau M, Dournovo P, Thibault Ph (1981) Les seminomes thymiques. Nouv Presse Med 10:3397-3400

Knapp RH, Fritz SR, Reiman HM (1982) Primary embryonal carcinoma and choriocarci­noma of the mediastinum. A case report. Arch Pathol Lab Med 106:507-509

Knowles DM, Halper JP (1982) Human T-cell malignancies. Correlative clinical, histopa­thologic, immunologic, and cytochemical analysis of 23 cases. Am J Pathol 106:187-203

Kountz SL, Connolly JE, Cohn R (1963) Seminomalike (or seminomatous) tumors of the anterior mediastinum. Report of 4 cases and review of the literature. J Thorac Cardiovasc Surg 45:289-301

Lattes R, Pachter MR (1962) Benign lymphoid masses of probable hamartomatous na­ture. Analysis of 12 cases. Cancer 15: 197-214

Leder L-D (1965) Fermenthistochemische Befunde bei chronischer Erythroblastose und akuter Erythramie. Klin Wochenschr 43: 795-796

Lee SL, Rosner F, Rivero I, Feldman F, Hurwitz A (1965) Refractory anemia with abnormal iron metabolism. Its remission after resection of hyperplastic mediastinal lymph nodes. New Engl J Med 272:761-766

Lennert K (1964) Pathologie der Halslymphknoten. Ein Abriss fUr Pathologen, Kliniker und praktizierende Arzte. Springer, Berlin Gattingen Heidelberg

Lennert K (1976) Klassifikation und Morphologie der non-Hodgkin-Lymphome. In: Lamer H (Hrsg) Maligne Lymphome und monoklonale Gammopathien. J.F. Leh­manns, Miinchen S 145-166

Lennert K (in collaboration with Mohri N, Stein H, Kaiserling E, Miiller-Hermelink HK) (1978) Malignant lymphomas, other than Hodgkin's disease. Histology, cytology, ultrastructure, immunology. In: Uehlinger E (Hrsg) Handbuch der speziellen patholo­gischen Anatomie und Histologie. Bd 1/3. Bandteil B. Springer, Berlin Heidelberg New York

Lennert K (in Zusammenarbeit mit Stein H) (1981) Histopathologie der non-Hodgkin­Lymphome (nach der Kiel-Klassifikation). Springer, Berlin Heidelberg New York

Levasseur Ph, Kaswin R, Rojas-Miranda A, N'Guimbous J-F, Merlier M, LeBrigand H (1976) Profil des tumeurs chirurgicales du mediastin. A propos d'une serie de 742 operes. Nouv Presse Med 5:2857-2859

Levine GD (1973) Primary thymic seminoma - A neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma. Cancer 31 :729-741

Levine GD, Bearman RM (1980) The thymus. In: Johannessen JV (ed) Electron micro­scopy in human medicine. Vol 5: Cardiovascular system, lymphoreticular and hemato­poietic system. McGraw-Hill International Book Comp, New York etc., pp 214-254

Levine GD, Rosai J (1978) Thymic hyperplasia and neoplasia: A review of current concepts. Hum Pathol 9:495-515

Lowenhaupt E, Brown R (1951) Carcinoma of the thymus of granulomatous type. A clinical and pathological study. Cancer 4: 1193-1209

Lukes RJ, Collins RD (1974) Immunologic characterization of human malignant lympho­mas. Cancer 34: 1488-1503

Marshall AHE, Wood C (1957) The involvement of the thymus in Hodgkin's disease. J Pathol 73: 163-166

Martin C, Pena ML, Angulo F, Garcia F, Vaca D, Serrano R (1982) Castleman's disease in identical twins. Virchows Arch [Pathol Anat] 395: 77-85

Martini N, Golbey RB, Hajdu SI, Whitmore WF, Beattie EJ (1974) Primary mediastinal germ cell tumors. Cancer 33:763-769

Mason DY, Biberfeld P (1980) Technical aspects oflymphoma immunohistology. J Histo­chern Cytochem 28:731-745

Moir DH (1981) Giant lymph node hyperplasia. Pathology 13:655-656 Moir DH, Choy T, Dalton WR (1982) Giant lymph node hyperplasia: Persistence of

symptoms for 15 years. Cancer 49:748-750

290 Literatur zu Teil 2

Mufarrij A, Fazzini E, Feiner HD (1982) Giant lymph node hyperplasia. An immunopa­thologic and ultrastructural study of a case of the multicentric plasma cell variant. Arch Pathol Lab Med 106:92-95

Mukai K, Adams WR (1979) Yolk sac tumor of the anterior mediastinum. Case report with light- and electronmicroscopic examination and immunohistochemical study of alpha-fetoprotein. Am J Surg Pathol 3: 77-83

Nathwani BN, Kim H, Rappaport H (1976) Malignant lymphoma, lymphoblastic. Cancer 38:964-983

Nickels J, Franssila K, Hjelt L (1973) Thymoma and Hodgkin's disease of the thymus. Acta Pathol Microbiol Scand Sect A 81: 1-5

Null JA, LiVolsi VA, Glenn WWL (1977) Hodgkin's disease of the thymus (granuloma­tous thymoma) and myasthenia gravis. A unique association. Am J Clin Pathol 67:521-525

Pachter MR, Lattes R (1964) "Germinal" tumors of the mediastinum: A clinicopatho­logic study of adult teratomas, teratocarcinomas, choriocarcinomas and seminomas. Dis Chest 45:30f-310

Polansky SM, Barwick KW, Ravin CE (1979) Primary mediastinal seminoma. Am J Roentgenol 132: 17-21

Prym P (1927) Spontanheilung eines bosartigen, wahrscheinlich chorionepitheliomatosen Gewachses im Hoden. Virchows Arch [pathol Anat] 265:239-258

Raghavan D, Barrett A (1980) Mediastinal seminomas. Cancer 46: 1187-1191 Recondo J, Libshitz HI (1978) Mediastinal extragonadal germ cell tumors. Urology

11 :369-375 Remigio PA (1971) Granulomatous thymoma associated with erythroid hypoplasia. Am

J Clin Pathol 55: 68-72 Ridell B, Larsson S (1980) Coexistence of a thymoma and Hodgkin's disease of the

thymus. Acta Pathol Microbiol Scand Sect A 88: 1-4 Rosai J, Levine GD (1976) Tumors of the thymus. In: Atlas of tumor pathology. Sec.

Ser., Fasc. 13. Armed Forces Institute of Pathology, Washington, DC Rosen PJ, Feinstein DI, Pattengale PK, Tindle BH, Williams AH, Cain MJ, Bonorris

JB, Parker JW, Lukes RJ (1978) Convoluted lymphocytic lymphoma in adults. A clinicopathologic entity. Ann Intern Med 89:319-324

Saegesser F, Zoupanos G, Jayet A, Gardiol D (1972) Tumeurs germinales malignes du mediastin. Ann Chir Thorac Cardiovasc 11 :71-82

Schantz A, Sewall W, Castleman B (1972) Mediastinal germinoma. A study of 21 cases with an excellent prognosis. Cancer 30: 1189-1194

Schlumberger HG (1946) Teratoma of the anterior mediastinum in the group of military age. A study of sixteen cases, and review of theories of genesis. Arch Pathol 41:398-444

Schlumberger HG (1951) Tumors of the mediastinum. In: Atlas of tumor pathology, Fasc. 18. Armed Forces Institute of Pathology, Washington, DC

Schmid KO, Albrich W, Repp P, Polzl J, ZeiteIberger P (1973) Retroperitoneal Castleman lymphoma. Beitr Pathol 149:196-205

Scully RE, Galdabini JJ, McNeely BU (1976) Case records of the Massachusetts General Hospital. Case 50-1976. New Engl J Med 295:1367-1374

Stein H, Tolksdorf G, Lennert K (1980) T-cell neoplasia in the perspective of normal T-cell differentiation. In: Tweel JG van den (ed) Malignant lymphoproliferative disea­ses. Leiden University Press, The Hague Boston London, pp 315-329

Stein H, Staudinger M, Tolksdorf G, Lennert K (1981) Immunologic markers in the differential diagnosis of non-Hodgkin's lymphomas. J Cancer Res Clin Oncol 101 :29-42

Steiner PE (1943) Hodgkin's disease. The incidence, distribution, nature and possible significance of the lymphogranulomatous lesions in the bone marrow: A review with original data. Arch Pathol 36:627-637

Sternberg C (1916) Leukosarkomatose und Myeloblastenleukamie. Beitr Pathol Anat 61:75-100

Differentialdiagnostisch wichtige Mediastinaltumoren und tumorartige Liisionen 291

Symmers WStC (1978) The lymphoreticular system. In: Symmers WStC (ed) Systemic pathology, 2nd ed, Vol 2. Churchill Livingstone, Edinburgh London New York, pp 50~891

Thomas WJ, Kelleher JF, Duval-Arnould B (1981) Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood. Cancer 48:2371-2374

Thomson AD (1955) The thymic origin of Hodgkin's disease. Brit J Cancer 9: 37-50 Weisenburger DD, DeGowin RL, Gibson DPh, Armitage JO (1979) Remission of giant

lymph node hyperplasia with anemia after radiotherapy. Cancer 44:457-462 Wychulis AR, Payne WS, Clagett OTh, Woolner LB (1971) Surgical treatment of media­

stinal tumors. A 40 year experience. J Thorac Cardiovasc Surg 62:379-391 Yu GSM, Carson JW (1976) Giant lymph-node hyperplasia, plasma-cell type, of the

mediastinum, with peripheral neuropathy. Am J Clin PathoI66:4~53 Zettergren L (1961) Probably neoplastic proliferation of lymphoid tissue (follicular lym­

pho-reticuloma). Acta Pathol Microbiol Scand 51: 113-126

Sachverzeichnis

Aa. thymicae 38 Adenosin-Desaminase-Mangel 95 "Afferent limb defect" 102 Agammaglobuliniimie, Schweizer Form

95,97ff. Akzessorisches Thymusgewebe 31,33,36 Aleukozytose, kongenitale 95 Alters-Atrophie, Thymus 83 Alters-Involution, Thymus 83 Alymphoplasie, thymische 95, 98 Angio-follikuliire Lymphknoten-

Hyperplasie 128,228ff. Aplastische Aniimie 185, 188, 213, 216 Apoplexia thymica 115,218 Ataxia teleangiectatica 101, 105

IgA-Mangel 101, 102 IgA-Mangel-Sprue 102 onkofetale Differenzierungsantigene

102 Sezary-Zellen 102 Syndrom-assoziierte Befunde 102

Ataxie, progressive zerebellare 101 Autoimmunthymitis 109

Basedow's disease, thymic form of 108 BCG-Tuberkulose, generalisierte 98 Blut-Thymus-Barriere 56, 77 Brustthymus 36 Brutons Hypogammaglobulinamie 91,

105

"Carcinoid tumours of of the thymus" 197

Castleman-Lymphom 228ff. "Choristome" 219 Circumscribed thymoma 125, 149 Clark-packet's 48, 49 "Clear cell thymoma" 138 Clear epithelial cells 48 "Clinical staging of thymoma" 167 "Common mucosal immunologic system"

102 Common thymocyte 64 Cytotoxische Lymphozyten 62

Defektimmunopathien 31,81, 89ff. Autoimmunerkrankungen 91 Inzidenz maligner Erkrankungen 104

Klassifikation 92 lympho-proliferative Syndrome 91 maligne Erkrankungen 103 Neoplasien 105 Pathogenese 90 phiinotypische Manifestationen 91 Tumormortalitiit 106

Dendritische Zellen 66ff. morphologische Charakteristika 67

Differenzierungsantigene,onkofetale 102 DiGeorge-Syndrom 100ff., 105 Disease, Glanzmann-Riniker 97 Diversifizierung I. Ordnung 58 Diversifizierung II. Ordnung 59 Diversifizierung III. Ordnung 65, 79 Dottersacktumoren 224 Duboissche Abszesse 115 Ductus thymo-pharyngeus 29 Dysgenesie, retikuliire 95, 96ff. Dysgerminome 222 ff. Dysplasie, thymische 99

Early thymocyte 64 Echinococcus-Zysten 219 Ektopisches Thymusgewebe 31, 36 Emperipolesis 49 Endokrine-like cells 73 Endokrinopathie, paraneoplastische 199 Enhancement-Phiinomene 104 Enlarged thymus 37 Entwicklung immunkompetenter Zellen

90 Entwicklungsgeschichte 29 ff.

Immigration 31 Pseudomorphose 31 Pseudotransformation 31 Transformation 31

Entziindungen 114 Eosinophiles Granulom 219 Epitheliale Retikulumzellen 41 ff. Epitheliale Thymustumoren 127ff. Epithelk6rperchen 33 Epithelzellen 41 ff.

"epitheloide" 48 gland-like spaces 47 Intermediiirfilamente 41 intrazytoplasmatische Zysten 47 Mikrofilamente 44

294 Sachverzeichnis

Epithelzellen "squamoide" 48 "synzytiale" 48 Tissue polypeptid antigen 44 zytoplasmatische Vakuolen 47

Etymologie, Thymus 1 Extended thymectomy 36, 175 Extra cortical central area 40

Facteur thymique serique 57, 59, 80 Fehlbildungen 31ff. Fettgewebskorper, thymischer 84 Fiber-associated reticulum cells 66 Fibrillary epithelial cells 48 Fireman-Syndrom 99 Follikelhyperplasie 108 Funktionseinheit, lymphoepitheliale 49

Giant lymph node hyperplasia 228,231 Synonyma 231

Gitlin-Syndrom 95, 98 Glandula parathyreoidea 29 Glanzmann-Riniker disease 97 Good-Syndrom 91, 105 "Graft-versus-host" -Reaktionen 96 Granulom, eosinophiles 219 Granulozyten, eosinophile 72

Halsthymus 31 Hassallsche Korperchen 29, 49ff., 144

" Blut-Thymus-Barriere" 56 conglomerierte 51 cystische 51 "dense-core granules" 53 funktionelle Bedeutung 56 Histogenese 54 immunhistologische Keratinbefunde 56 Intermediarfilamente 53 Keratine 53 ff. Keratinosomen 52 kompakte 51 "membrane-coating granules" 52 Mikrofilamente 53 multizellulare 51 Odland bodies 52 progressive 51 "quantitative Morphologie" 53 regressive 51 "secretory-like granules" 53 solide 51 unizellulare 51

Helfer-(inducer-)Zellen 65 Heterogenitat, lymphozytare 58 Histiozytare Tumoren 206 Histologie 38 ff. HLA-ABC 57 HLA-DR (la-like antigen) 57 Homeostatic thymic hormone (HTH) 80

Human thymic epithelial conditioned medium (HTECM) 80

Hydatid disease 219 Hyperplasie, numerische 107 Hypogammaglobulinamie 185, 188,213 Hypogammaglobulinamie, transitare 105

IgA-Mangel 101 IgA-Mangel, selektiver 91, 105 IgA-Mangel-Sprue 102 Ig-Mangel mit Hyper-IgM 105 IgM-Mangel, selektiver 91, 105 Immundefekte, assoziierte Fehlbildungen

99 Chondrodysplasie 100 epiphysare Dysostosen 100 Knorpel-Haar-Hypo-jDysplasie 100 kombinierte 91

Immune surveillance 103, 104 Immunglobulinmangel-Syndrome 91 Immunkompetente Zellen, Entwicklung

90 "Zwei-Komponenten-Theorie" 90

Immunmangel mit normalen Serum-y-Globulinen 105

Immunmangel, Thymome 91 Immunmangel-Syndrome 89ff., 91, 105

Einteilung 91 "graft-versus-host" Reaktionen 96 inkomplette Formen 95 inkomplette/sporadische Formen 99 Knochenmarkstransplantation 96 "lamina flow unit" 96 metabolische Defekte 95 schwere kombinierte 95, 105 sporadische Formen 95 Thymom assoziiert 188 T-Zellen-Defizienz 91 variable 105

Imprint-Zytologie 193, 233 Inborn errors of metabolism 95 Inborn errors of purine metabolism 95 "Incidental microscopic thymoma" 130 Indeterminate dendritic cells 67 Infarzierungen, hamorrhagische 115 Inter cortical central area 40 Interleukin 80 Intermediarfilamente 53, 133 Involution, Thymus 83

lugularthymus 31

Karzinoide, Thymus 197ff. Karzinom, sarkomatoides 126, 139, 206 Keimzelltumoren 220

Differenzierungsmuster 221 extragonadale 123

Sachverzeichnis 295

Histogenese 220 mediastinale 126

Keimzentrums-H yperplasie 109 Keimzentrumsreaktion, medulliire 109 Kompartiment, extraparenchymales 39,

111 intraparenchymales 39, 111 subkapsuliires 39

Krankheiten, extrathymische 183 Thymom-assoziiert 190

Kultschitzky-Zellen 72ff.

Lambert-Eaton-Syndrom 188 Langerhans-Zellen 67,72

Birbeck-Granula 72 "Leukemogenic thymoma" 189 Lipopigment cells 68 Louis-Bar-Syndrom 101 Lupus erythematodes 185 L ymphknoten-H yperplasie,

angiofollikuliire 128 Lymphocyte-stimulating hormone (LSH)

80 Lymphome, maligne 220, 225ff.

T-Iymphoblastische 227 Lymphopenie, episodische 105 Lymphorrhagien 112 Lymphozyten 144

cytotoxische 62 myotoxische 112

L ymphozytendifferenzierung, intrathymische 60 tierexperimentelle Befunde 60

LymphozytenjThymozyten 57ff. Lymphozytophthise, essentielle 97

Makrophagen 66 ff. Typ I 48,66 Typ II 68 Typ III 68 Typ IV 69

Maligne Erkrankungen, Defektimmunopathien 103

Maligne Thymome 125, 178 Basaloid carcinoma 125 Category I 125 Category II 125 "Clear cell carcinoma" 125 Lymphoepithelioma-like carcinoma

125 Mixed small cell and undifferentiated-

squamous cell carcinoma 125 Mucoepidermoid carcinoma 125 sarcomatoid carcinoma 125 squamous cell carcinoma 125 Undifferentiated carcinoma 125

Malignes Histiozytom, Thymus 209 Mark (Medulla) 39

Mastzellen 72 Mature thymocyte 65 Mediastinalfibrose, idiopathische 206 Mediastinaltumoren 129

Differentialdiagnose 220 Lokalisation 129 Ultrastruktur 196

Mediastinitis, fibrose 206 granulomatose 206

Mesenchymale Thymustumoren 206ff. Metaplasie, thyreo-parathyreo-thymische

36 Metastasen, Thymus 191 Methoden 232ff.

Elektronenmikroskopie 240 Immunhistologie 237 Imprint-Zytologie 233 Paraffin-Histologie 233

Microenvironment, Thymus 59, 79, 81, 82,95

Morbus Hodgkin 123, 227 Multiple endokrine Adenopathie, Typ 1

(MEA 1) 199 Myasthenia gravis 36, 130, 148, 167, 185,

186,213 Acety1cholinrezeptoren 112 Altersverteilung 187 "Autoimmun-Thymitis" 112 Q(-Bungarotoxin 113 experimentelle Modelle 114 Immunpathogenese 112 Keimzentrumsreaktion 187 "Lymphorrhagien" 112 myoide Thymuszellen 112 myotoxische Lymphozyten 112 non-thymomatous 186 Serumantikorper 113 Thymitis 111 Thymotoxikose 112

Myo-Blastom 206 "Myogene Korper" 51,73 Myoide Thymuszellen 73 Myosarkome 206

Nebenschilddriisen-Aplasie 101 Nezelof-Syndrom 95,100 Non-thymomatous myasthenia gravis 111 Nossal's follicular dendritic reticulum

cells 66,67 nude-Miiuse 30, 101 Nurse cells, mesenchymale 67

Oat cell-Karzinom, Thymus 205

Parathymische Syndrome 176ff., 182, 189 Parathyreoidea, Aplasie 101 Perivaskuliire Spaltriiume 76ff., 142

296 Sachverzeichnis

Perivaskuliire Spaltriiume Blut-Thymus-Barriere 77, 79 "Schleusenfunktion" 78

"Pharyngeal pouch syndrome" 100 Phythiimagglutinin 59 Plasmazellen 72 Pleuratumoren, fibrose 206 Polymyositis 185 Postthymektomie-Syndrome 168, 186,

189 "Post-thymectomy wasting syndrome" 81 Potentially secretory epithelial cells 48 Prothymozyten 59 Purin-N uc1eosid -Phosphorylase-Mangel

95

Retikuliire Dysgenesie 95, 96ff. Retikulumzellen 66ff.

dendritische 66 fibroblastische 66 interdigitierende 66, 67, 69 ff. phagozytierende (histiozytische) 66

Rheumatoide Arthritis 185 Rinde (Cortex) 39 Rinden-Mark-Index 84 Rindenzone, iiuBere 39

innere 39

Sanduhrthymus 33 Sarcolyten 51, 73 Sarkom, myoidzelliges 126 Sarkome, myoidzellige 206 Schlundtaschenepithel, Homodynamie 30 Schwere kombinierte Immunmangel-

Syndrome 105 Selektiver IgA-Mangel 105 Selektiver IgM-Mangei 105 "Seminomatous thymoma" 126 Seminome 222 fT.

IX-Fetoprotein 224 Karzinoembryonales Antigen 224 Tumormarker 224 Seminomes thymiques 224 Human Chorionic Gonadotropin 224

Severe combined immunodeficiency disease (SCID) 95ff.

Sezary-Zellen 102 Sinustumoren, endodermale 224 Sipple-Syndrom 199 Spaltriiume, perivaskuliire 40, 76 Speicherungen, Thymus 88 Spindle epithelial cells 48 Spindle-shaped-cell area 40 Status thymico-lymphaticus 106 Status thymicus 108 Steinman-Cohns' dendritic cells 66, 67 Sternberg's lymphoma of the thymus 127,

227

Stoffablagerungen, Thymus 88 Stress-Involution, Thymus

akute 87 akzidentelle 87 chronische 87 Hunger 87

"Sudden infant death syndrome" 108 Suppressor /zytotoxische T -Lymphozyten

65 Syndrome, parathymische 189

T cell growth factor (TCGF) 80 Tardieusche Flecke 115 Teratome 130, 220 T-Helferzellen 61 Third area 40 Thorakalthymus 36 "Thymectomy, extended" 175 Thymektomie 36, 177

Ausfallserscheinungen 81 neonatale 97

"Thymic education" 59, 79, 81 Thymic factor (TF) 59 Thymic humoral factor (THF) 59, 80 Thymic hypocalemic factor 80 Thymic hypoplasia 100 Thymic leukemia (TL-) antigen 61 "Thymic nurse cells" 48 Thymische Alymphoplasie 98 Thymische Dysplasie 99 Thymitis 108,109,111,114

experimentelle Modelle 114 Myasthenia gravis 111

Thymo-Blastom 126,206 Thymogene Geschwiilste

Klassifikation 126 Thymogene Zysten 31,216 Thymolipome 206, 210ff.

Aniimie 213 Aplastische Aniimie 216 Histogenese 214 Hyperthyreose 216 Hypogammaglobuliniimie 213 Myasthenia gravis 213 Pathogenese 214

Thymom 36, 116, 127ff. Altersverteilung 128 Anmerkungen zur Therapie 197 aplastische Aniimie 188 assoziierte extrathymische Tumoren

189 assoziierte Immunmangel-Syndrome

188 assoziierte Krankheiten 185, 190 assoziierte Syndrome 183, 185 asymptomatisches 185 Begriffsinhalte 124 "blande Neoplasie" 125, 178

Sachverzeichnis 297

"clinical staging" 167 Diagnose 191 "en bloc"-Resektion 175 "epitheliales" 145 epitheloide Tumorzellen 133 extrathorakale Metastasen 182 Geschlechtsverteilung 128 "granulomatoses" 123 Hassallsche Korperchen 144 histiozyHire Schaumzellen 144 histologische Befunde 132ff. histologische Malignitiitskriterien 177 Hypogammaglobuliniimie 188 infiltratives Tumorwachstum 130 Intermediiirfilamente 133 "karzinoides" 123 Klassifikation 120 klinisches Staging 170, 173 lokale Symptome 182, 185 Lokalisation 128 "Lympho-epitheliales" 145 lymphozytiire Assoziation 146 "lymphozytiires" 145 Lymphozyten 144ff. "Lymphozyten/Epithel-Index" 180 Makroskopie 130 malignes 125, 178 Malignitiit 149 "Medullary differentiation" 140 morphologisch-funktionelle

Korrelationen 182 ff. Myasthenia gravis 186 parathymische Syndrome 176ff.,182 perivaskuliire Spaltriiume 142 Prognose 149, 169 Pseudozysten 132 regressive Veriinderungen 143 sarkomatoides 139 "seminomatoses" 123 spindelformige Tumorzellen 138

Differentialdiagnose 138 "starry sky pattern" 147 strukturelle Differenzierungsmuster 140 Therapieergebnisse 174 "transitional cell forms" 139 Wachstumsverhalten 167 zelluliire Differenzierungsmuster 133,

139 Zysten 132

Thymoma, circumscribed 125, 149 incidental microscopic 130 intratracheale 36 leukemogenic 189

Thymomektomie 168, 177 Thymopoietin 45,59,80 Thymoptose 33 Thymosin 45, 80 Thymosterin 80

Thymostimulin 80 Thymotoxikose 111 Thymozyten 59

Enzymmarker 62 immature 60 immunhistologische Befunde 64 kortikale 62

phiinotypische Merkmalsmuster 63 Kortikosteroid-sensitive 60 medulliire 63

phiinotypische Merkmalsmuster 64 Membranrezeptoren 62 IX-Naphthyl-Azetat-Esterase 62 "Peripheralisation" 66

Thymozytendifferenzierung intrathymische 63, 65

Thymozyten/Lymphozyten 57 ff. Thymus

Etymologie 1 Funktion 79ff. lymphatische Drainage 38 venoser AbfluB 38

Thymus magnus 106 Thymusaplasie 101 Thymus-Dysplasie 109 Thymusforschung, Geschichte 1 ff.

"Centrale Cavitiiten" 9 Etymologie 1 Lympho-epitheliales Gewebe 22 Pathologie 19 Physiologie 19 "Reticuliirer Bau" 13 Rinde und Mark 16

Thymusfragmentationen 33 Thymushormone 80ff. Thymushyperplasie 36,37, 106, 109

mors subita 106, 108 mors thymica 108

Thymushyperplasie, lymphofollikuliire Akromegalie 114 Aniimien 114 Autopsiestudien 114 Colitis ulcerosa 114 Lebererkrankungen 114 Lupus erythematodes 113 Morbus Addison 114 Morbus Basedow 113 Morbus Behcet 114 rheumatoide Arthritis 114 Sjogren-Syndrom 114 Sklerodermie 114 Thyreoiditis Hashimoto 113

Thymushypoplasie 92, 100, 101 Thymus-Involution 29,83

experimentelle Modelle 88 Thymus-Karzinoide 123, 138, 197ff.

Argyrophile Reaktionen 203 Chemotherapie 205

298 Sachverzeichnis

Thymus-Karzinoide Differentialdiagnose 204 F ormaldehyd-induzierte Fluoreszenz

203 Histochemische Befunde 202 Immunhistologische Befunde 202 Spindelzellige Variante 204

Thymus-Karzinome 125, 182 extrathorakale Metastasen 182

Thymus-Metastasen 191 Thymuspersistenz 37 Thymussyndrome, primare 183 Thymus-Tuberkulom, isoliertes 219 Thymustumoren 116ff.

epitheliale 123, 127ff. mesenchymale 206ff.

Thymuszelle, myoepitheliale 51 Thymuszellen, myoide 73,112 Thymus-Zysten 216 Topographie 36ff. True secretory cells 48 T -Suppressorzellen 62 Tuberkulose 219 Tumorartige Lasionen 31 Tumorartige Thymus-Lasionen 216ff.

"Tumorbildung im vorderen Mediastinum ... " 227

Tumoren 116ff. Definitionen 116 Klassifikation 116

T-Zell-Maturation, intrathymische 82

Undifferentiated epithelial cells 48

Vaccinia generalisata necroticans 98 Variable Immunmangel-Syndrome 105 Varied immunodeficiencies, common and

largely unclassified 99

Wermer-Syndrom 199 Wiskott-Aldrich-Syndrom 102,105

Paraproteine 103

Yolk -sac-Tumoren 224

Zellweger-Syndrom 100 Zervikaler Thymus 31 Zervikal-Thymome 36 Zysten, thymogene 216

Einteilung 217

Spezielle pathologische Anatomie Ein Lehr- und Nachschlagewerk

Begriindet von W. Doerr, E. Uehlinger Herausgeber: W. Doerr, G. Seifert

Gesamttibersicht

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12. Band: G.O.H.Naumann Pathologie des Auges Unter Mitarbeit zahlreicher Fachwissenschaftler 1980. 546 Abbildungen in 1003 Einzeldarstellun­gen, davon 115 zweifarbige schematische Skizzen, 1 Farbtafel, 188 differentialdiagnostische Tabellen. XLIX, 994 Seiten Gebunden DM 680,-; approx. US $ 263.90 Subskriptionspreis: Gebunden DM 544,-; approx. US $ 211.10 ISBN 3-540-09209-9

13. Band: 1. Teil: Pathologie des Nervensystems I. DurchblutungsstOmngen und GefaBerkrankungen des Zentralnervensystems Von J.Cerv6s-Navarro, H.Schneider Redigiert von G. Ule 1980.263 Abbildungen in 374 Einzeldarstellungen, 4 Tabellen. XXI, 665 Seiten Gebunden DM 320,-; approx. US $ 124.20 Subskriptionspreis: Gebunden DM 256,-; approx. US $ 99.40 ISBN 3-540-09788-0

2. Teil: Pathologie des Nervensystems II. Entwickiungsstomngen, chemische und physikalische Krankheitsursachen Von H.Berlet, et at. Redigiert von G. Ule 1983.281 Abbildungen in 522 Einzeldarstellungen. XX, 964 Seiten Gebunden DM 680,-; approx. US $ 263.90 Subskriptionspreis: Gebunden DM 544,-; approx. US $ 211.10 ISBN 3-540-11536-6

14. Band: Pathologie der endokrinen Organe Von E.A1teniihr, et aI. Redigiert von G. Seifert 1981. 660 Abbildungen in 886 Einzeldarstellungen. XLIII, 1309 Seiten (In zwei minden, die nur zusam­men abgegeben werden). Gebunden: DM 780,-; approx. US $ 302.70 Subskriptionspreis: Gebunden DM 624,-; approx. US $ 242.20 ISBN 3-540-10132-2

15. Band: J.M.Schriider Pathologie der Muskulatur 1982. 190 Abbildungen in 582 Einzeldarstellungen, 18 Farbtafeln, 1 Falttafel. XXIII, 813 Seiten Gebunden DM 660,-; approx. US $ 256.10 Subskriptionspreis: Gebunden DM 528,-; approx. US $ 204.90 ISBN 3-540-11 069-0

16. Band: Pathologie der Lunge Von S.Bliimcke, et at. 1983.609 Abbildungen in 920 Einzeldarstellungen. XLVII, 1424 Seiten (In zwei Banden, die nur zusammen abgegeben werden). Gebunden DM 980,-; approx. US $ 380.30 Subskriptionspreis: Gebunden DM 784,-; approx. US $ 304.20 ISBN 3-540-11538-2

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