NeuroMed7®

Rapid-onset Topical Anesthetic (Lidocaine HCl 4%)

A time saving & cost effective solution

Peak onset begins 15 – 20 minutes after application

Background

Clinicians are increasingly using topical

anesthetics to decrease the pain

associated with minimally invasive

dermatologic, aesthetic, injection,

cannulation and laser procedures (among

others).

Numerous lidocaine-containing products

are available, but comprehensive studies

are lacking regarding their relative safety

and appropriate dermatologic uses.

Concept

Lidocaine-containing products play an

integral role in cutaneous anesthesia by

providing patient comfort with minimal side

effects. Careful attention must be paid to

the particular anatomic location, the total

surface area covered, active ingredient

concentration and the duration of

anesthetic skin contact.

Awareness

Topical anesthetics decrease pain during

superficial cutaneous procedures. As the

number of in-office dermatologic

procedures continues to grow, clinicians

will benefit from awareness of the

indications, pharmacologic mechanisms,

appropriate methods of application, and

safety profiles of the currently available

prescription and over-the-counter (OTC)

topical anesthetics.

Mechanism of Action

Once inside the dermis, ester and amide

anesthetics possess the same mechanism

of action. The anesthetic binds the voltage-

gated sodium ion channel of the free nerve

endings and blocks sodium influx. The

blockade of sodium influx inhibits nerve cell

depolarization and prevents propagation of

nerve cell impulses along the nerve. Meechan

JG. Intraoral topical anesthesia. Periodontal 2000 2008;46:6 - 79

NeuroMed7® OTC Rapid Onset

Topical Anesthetic can be used

for:

• Superficial aesthetic procedures

• Hair and tattoo removal

• Minimally invasive excisions

• Injections

• Cannulation procedures

• Other minimally invasive procedures

and uses as directed by a licensed

physician

Proprietary formulation

• Designed to improve absorption

• Rapid-onset of action – 15 – 20 minutes

• Medium duration of efficacy –

approximately 60 minutes

• Safe and effective

• Patent-pending

Designed to improve absorption

• Rapid-onset – 15 to 20 minutes

• Medium duration – 60 minutes

• Safe and effective

• Easy to apply and remove

• Free of oily or gritty residue

A time saving & cost effective solution

• Save time - peak onset of action – 15 –

20 minutes

• Save money – only $23 per 2.2 ounce

(63 gram) tube – as low as $19 per tube

for bulk orders

• Increase practice revenue – can be

dispensed as a retail item for clinician-

directed, patient self-application – at

high margins

• Increase efficiency– reduced onset of

action time can increase patient flow

efficiency

Proper application

• Clean treatment area with mild cleanser and

damp, clean cloth to remove any dirt, make-

up or other material that may impede

absorption.

• Use approximately a “US quarter

dollar”(or one packet) size amount per

4”x4” area 15 - 20 minutes prior to

procedure (recommended dose – 0.75 –

2.0 grams – or milliliters – per 1”X1”

square area

• Dosage will depend on the skin type,

aggressiveness of procedure, known

patient pain tolerance and surface area.

• Use the least amount of product necessary

to achieve the required amount of local

anesthesia

Proper application – cont’d

• Avoid use on open wounds, broken skin, eyes, ears, in the nostrils andmouth

• With a gloved hand, evenly distribute the cream and rub vigorously in acircular motion for at least 30 – 60 seconds to each area of the treatment surface

• Apply more aggressively to known pain-sensitive “hot spot” areas on the face and body

• The peak action begins in approximately 15 – 20 minutes

Proper application – cont’d

• Some clinicians use an occlusivedressing for an improved efficacy –occlusion should be determined by alicensed physician.

• It is important to note that applying a hot or warm compress to the treatment area prior to application of NeuroMed7® will increase cutaneous absorption. While this method will enhance the effect of the anesthetic, special care should be exercised in recognition of the potential for increased systemic entry of the active ingredient, lidocaine HCL 4%

• Do not exceed 10 grams (milliliters) per application

• Physician should take into account total anesthetic dose when using this product in combination with other anesthetic products

Contact Sambria

Pharmaceuticals or your local

representative

1075 Peachtree Street NE, Suite 3650

Atlanta, Georgia 30309

888.246.6601 | info@sambriapharma.com |

www.sambriapharma.com

THANK YOU!