OXYGEN TRANSPORT TOTISSUE XXIV

Jeffrey F. DunnHarold M. Swartz

Library of Congress Cataloging-in-Publication Dat a

International Society on Oxygen Transport to Tissue . Meeting (27th : 1999 : Hanover, N.H. )

Oxygen transport to tissue XXIV/edited by Jeffrey F . Dunn and Harold M . Swartz .

p. ; cm . - (Advances in experimental medicine and biology ; v. 530)

"Presentations made at the 27th Annual Meeting of the International Society on Oxygen

Transport to Tissue (ISOTT) . . . . held in Hanover, NH, USA, at Dartmouth Medical School"-Pref .

Includes bibliographical references and index .

ISBN 0-306-47774- 2

1 . Oxygen-Physiological transport-Congresses . 2. Tissue respiration-Congresses . I.

Title: Oxygen transport to tissue 24 . II . Title : Oxygen transport to tissue twenty-four . III .

Dunn, Jeffrey F. (Jeffrey Frank) . 1956- IV. Swartz, Harold M . V. Title. VI . Series.

[DNLM: 1 . Oxygen Consumption-physiology-Congresses . 2. Biological

Transport-physiology-Congresses . 3. Oxygen-metabolism-Congresses . WF 110 161o 2004 ]

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This is a proceedings of the 27th annual meeting of the International Society on Oxygen Transport to Tissu e

(ISOTT), held at Dartmouth Medical School, Hanover, New Hampshire, from August 28-September 2, 1999 .

ISBN 0-306-47774- 2

©2003 Kluwer Academic /Plenum Publishers, New Yor k

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METHODS FOR ASSESSING OXYGEN IN TISSUES

1 . MEASUREMENTS OF OXYGEN IN TISSUES: OVERVIEW ANDPERSPECTIVES ON METHODS

1Harold M. Swartz and Jeff F . Dun n

2. QUANTITATIVE BRAIN TISSUE OXIMETRY, PHAS ESPECTROSCOPY AND IMAGING THE RANGE O FHOMEOSTASIS IN PIGLET BRAIN

1 3Britton Chance, Hon Yan Ma, and Shoko Nioka

3. TUMOR OXIMETRY : COMPARISON OF 19 F MAGNETICRESONANCE ECHO PLANAR IMAGING ANDELECTRODES

1 9Ralph P . Mason, Sandeep Hunjan, Anca Constantinescu, Yulin Song ,Dawen Zhao, Eric W . Hahn, Peter P . Antich, and Peter Peschke

4 . MAPPING CEREBRAL GLUTAMATE 13C TURNOVER ANDOXYGEN CONSUMPTION BY IN VIVO NMR

29Fahmeed Hyder, Peter Brown, Terennce W . Nixon, and Kevin L . Behar

5. MONTE-CARLO SIMULATION OF LIGHT TRANSPORT FO RNIRS MEASUREMENTS IN TUMORS OF ELLIPTI C

GEOMETRY

4 1Mojca Pavlin, Tomaz Jarm, and Dainijian Miklav~iir

6 . ARTERIAL PULSATIONS ARE PRESENT IN ONE THIRD OF TH EHUMAN CRANIAL VASCULAR VOLUME PENETRATE DBY NEAR-INFRARED LIGHT

5 1Robert Stingele, Emanuela Keller, Benedicht P . Wagner, Thorste nSteiner, Karoline Stingele, and Werner Hacke

7 . ABSOLUTE FREQUENCY-DOMAIN PULSE OXIMETRY OF THEBRAIN: METHODOLOGY AND MEASUREMENTS

6 1Martin Wolf, Maria A . Franceschini, Lelia A . Paunescu, Vlad Toronov ,Antonios Michalos, Ursula Wolf, Enrico Gratton, and Sergio Fantini

8 . THE INFLUENCE OF A CLEAR LAYER ON NEAR-INFRARE DSPECTROPHOTOMETRY : COMPARISON OFMEASUREMENTS IN A LIQUID NEONATAL HEA DPHANTOM TO INFANTS IN VIVO

75Martin Wolf, Matthias Keel, Vera Dietz, Kurt von Siebenthal, Jan Teller ,Hans-Ulrich Bucher, and Oskar Baenzige r

9 . STRATEGIES FOR ABSOLUTE CALIBRATION OF NEA RINFRARED TOMOGRAPHIC TISSUE IMAGING

8 5Troy O. McBride, Brian W . Pogue, Ulf L. Osterberg, and Keith D . Paulse n

10. BRAIN TISSUE AND SAGITTAL SINUS p02 MEASUREMENTSUSING THE LIFETIMES OF OXYGEN-QUENCHEDLUMINESCENCE OF A RUTHENIUM COMPOUND

10 1Casmiar I . Nwaigwe, Marcie A . Roche, Oleg Grinberg, and Jeff F . Dun n

11 . PRELIMINARY STUDIES ON THE PHOTON PATH IN BREAS TTISSUE MODEL BY NIR-TRS

11 3Arisha L . Honar, Cory Ricks, and Kyung A . Kan g

12. EPR SPECTROSCOPY AND IMAGING OF OXYGEN :APPLICATIONS TO THE GASTROINTESTINAL TRACT

12 3Jay L . Zweier, Guanglong He, Alexandre Samouilov, and Perianna nKuppusamy

PROTEIN C ENGINEERING ISSUE S

13 . EFFECTS OF BLOCKING BUFFERS AND PLASMA FACTORS O NTHE PROTEIN C BIOSENSOR PERFORMANCE

13 3Heath I . Balcer, James O . Spiker, and Kyung A . Kang

14 . PROTEIN C SEPARATION FROM HUMAN BLOOD PLASM ADERIVATIVES USING LOW COST CHROMATOGRAPHY

J4 3Huiping Wu and Duane F. Bruley

OXYGEN IN TUMORS

15. GLUTATHIONE DEPLETION OR RADIATION TREATMENTALTERS RESPIRATION AND INDUCES APOPTOSIS I NR3230AC MAMMARY CARCINOMA

15 3John E . Biaglow, Intae Lee, Jerry Donahue, Kathy Held, John Mieyal ,Mark Dewhirst, and Steve Tuttl e

16. OXYGENATION AND VASCULAR PERFUSION I NSPONTANEOUS AND TRANSPLANTEDTUMOR MODELS

16 5Bruce M . Fenton and Scott F . Paon i

17. EFFECT OF MILD HYPERGLYCEMIA ± META-IODO -BENZYLGUANIDINE ON THE RADIATION RESPONSEOF R3230 AC TUMORS

17 7Intae Lee, Jerry D. Glickson, Mark W. Dewhirst, Dennis B . Leeper ,Randy Burd, Harish Poptani, Lydie Nadal, W . Gillies McKenna, and JohnE . Biaglo w

18 . EFFECT OF ONCONASE t TAMOXIFEN ON ASPC-1 HUMA NPANCREATIC TUMORS IN NUDE MICE

187Intae Lee, Young H . Lee, Stanislaw M . Mikulski, and Kuslima Shoge n

19 OXYGENATION IN A HUMAN TUMOR XENOGRAFT :MANIPULATION THROUGH RESPIRATORYCHALLENGE AND ANTIBODY-DIRECTED INFARCTION

197Ralph P . Mason, Anca Constantinescu, Sophia Ran, and Philip E . Thorp e

20. TUMOR pO2 ASSESSMENTS IN HUMAN XENOGRAFT TUMOR SMEASURED BY EPR OXIMETRY : LOCATION OFPARAMAGNETIC MATERIALS

205Julia A . O'Hara, Rosalyn D . Blumenthal, Oleg Y . Grinberg, Stalin aGrinberg, Carmen Wilmot, David M . Goldenberg, and Harold M . Swartz

21. HEMOGLOBIN IMAGING WITH HYBRID MAGNETI CRESONANCE AND NEAR-INFRARED DIFFUSETOMOGRAPHY

21 5Brian W . Pogue, Haoqin Zhu, Casmair Nwaigwe, Troy O . McBride, Ul fL . Osterberg, Keith D . Paulsen, and Jeffrey F. Dun n

22. TUMOR OXYGEN DYNAMICS : COMPARISON OF 19F MR EP IAND FREQUENCY DOMAIN NIR SPECTROSCOPY

22 5Yulin Song, Kate L. Worden, Xin Jiang, Dawen Zhao, Anc aConstantinescu, Hanli Liu, and Ralph P . Mason

23 . MICROCIRCULATORY FUNCTION, TISSUE OXYGENATION ,MICROREGIONAL REDOX STATUS AND ATPDISTRIBUTION IN TUMORS UPON LOCALIZE DINFRARED-A-HYPERTHERMIA AT 42°C

237Oliver Thews, Yanping Li, Debra K . Kelleher, Britton Chance, and PeterVaupel

ENHANCING OXYGENATIO N

24 . ALLOSTERIC MODIFICATION OF HEMOGLOBIN BY RSR13 A SA THERAPEUTIC STRATEGY

24 9Robert P . Steffen, Jean-Francois Liard, Michael J . Gerber, and Stephen J .Hoffma n

25. THE PHARMACOLOGY OF TISSUE OXYGENATION B YBIOPURE'S HEMOGLOBIN-BASED OXYGEN CARRIER ,HEMOPURE® (HBOC-201)

26 1L. Bruce Pearce and Maria S . Gawry l

26 . THE CONCEPT OF HEMOGLOBIN EQUIVALENCY O FPERFLUOROCHEMICAL EMULSIONS

27 1N. Simon Faithful l

27. THE DOSE-DEPENDENT EFFECT OF RSR13, A SYNTHETICALLOSTERIC MODIFIER OF HEMOGLOBIN, O NPHYSIOLOGICAL PARAMETERS AND BRAIN TISSU EOXYGENATION IN RATS

287Oleg Y . Grinberg, Minoru Miyake, Huagang Hou, Robert P . Steffen, andHarold M . Swartz

28. COMPUTER MODELING OF RELATIONSHIP BETWEE NCRITICAL PVO2, VO2MAX AND BLOOD SUPPLY O FSKELETAL MUSCLE AT WORKING WITH A RIGHT -SHIFTED BLOOD 02 DISSOCIATION CURVE

29 7Katherine G. Lyabakh and Irinia N . Mankovskaya

29. SMALL-VOLUME RESUSCITATION WITH THE HEMOGLOBI NSUBSTITUTE HBOC-201 : EFFECT ON BRAIN TISSU EOXYGENATION

31 1Geoffrey T . Manley, J . Claude Hemphill, Diane Morabito, Vaness aErickson, John J . Holcroft, Nakita Derugin, and M . Margaret Knudson

30 . EFFECT OF RSR13, A SYNTHETIC ALLOSTERIC MODIFIER OFHEMOGLOBIN, ON BRAIN TISSUE pO2 (MEASURED BYEPR OXIMETRY) FOLLOWING SEVER EHEMORRHAGIC SHOCK IN RATS

31 9Minoru Miyake, Oleg Y . Grinberg, Huagang Hou, Robert P . Steffen ,Hisham Elkadi, and Harold M . Swartz

31 . EXPRESSION OF MYOGLOBIN IN THE TRANSGENIC MOUS EBRAIN

33 1Ross D . Shonat and Alan P. Koretsk y

CNS OXYGENATION

32 . THE CEREBRAL MICROCIRCULATION IN ISCHEMIA AN DHYPOXEMIA

347Antal G . Hudetz

33. INVESTIGATING THE ROLE OF NITRIC OXIDE INREGULATING BLOOD FLOW AND OXYGEN DELIVER YFROM IN VIVO ELECTROCHEMICAL MEASUREMENTSIN EYE AND BRAIN

35 9Donald G . Buerk, Dmitriy N . Atochin, and Charles E . Riva

34. NIRS MONITORING OF PILOTS SUBJECTED TO +G zACCELERATION AND G-INDUCED LOSS O FCONSCIOUSNESS (G-LOC)

37 1Paul B . Benni, John K-J . Li, Bo Chen, Joseph Cammarota, and David W .Amory

35. CORRELATION OF NIRS DETERMINED CEREBRA LOXYGENATION WITH SEVERITY OF PILOT +G zACCELERATION SYMPTOMS

38 1Paul B . Benni, John K-J . Li, Bo Chen, Joseph Cammarota, and David W .Amory

36. ALTERED GENE EXPRESSION FOLLOWIN GCARDIOPULMONARY BYPASS AND CIRCULATORYARREST

39 1Tatiana Zaitseva, Gregory Schears, Jin Shen, Jennifer Creed, David F .Wilson, and Anna Pastuszko

37. DOMINANT EVENTS THAT MODULATE MASS TRANSFE RCOEFFICIENT OF OXYGEN IN CERERAL CORTEX

40 1Fahmeed Hyder, Ikuhiro Kida, Kevin L . Behar, Richard P. Kennan, and

•

Douglas L . Rothma n

38. RELATIONSHIP BETWEEN REDOX BEHAVIOR OF BRAI NCYTOCHROME OXIDASE AND NEUROLOGICA LPROGNOSIS

41 3Yasuyuki Kakihana, Tomotsu Kuniyoshi, Sumikazu Isowaki, Kazum iTobo, Etsuro Nagata, Naoko Okayama, Kouichirou Kitahara, Takahir oMoriyama, Takeshi Omae, Masayuki Kawakami, Yuichi Kanmura, an dMamoru Tamura

39. ARE VEP CORRELATED FAST OPTICAL SIGNAL SDETECTABLE IN THE HUMAN ADULT BY NON -INVASIVE NEAR-INFRARED SPECTROSCOPY (NIRS)?

42 1Frank Syr6, Hellmuth Obrig, Jens Steinbrink, Matthias Kohl, RüdigerWenzel, and Arno Villringer

APPLICATION OF BOLD IMAGING

40. USING HIGH SPECTRAL AND SPATIAL RESOLUTION BOL DMRI TO CHOOSE THE OPTIMAL OXYGENATIN GTREATMENT FOR INDIVIDUAL CANCER PATIENTS

43 3Hania A . Al-Hallaq, Marta A . Zamora, Brian L . Fish, Howard J .Halpern, John E . Moulder, and Gregory S . Karczma r

41. ISSUES IN GRE & SE MAGNETIC RESONANCE IMAGING T OPROBE TUMOR OXYGENATION

44 1Franklyn A . Howe, Simon P . Robinson, Loreta M . Rodrigues, Mario nStubbs, and John R . Griffiths

42 . FMRI FOR MONITORING DYNAMIC CHANGES IN TISSUEOXYGENATION/BLOOD FLOW : POTENTIA LAPPLICATIONS FOR TUMOR RESPONSE T OCARBOGEN TREATMENT

44 9Jianhui Zhong, W .C .Edmund Kwok, and Paul Okunieff

43. COMPARISON STUDY OF OXYGEN-INDUCED MRI-SIGNA LCHANGES AND pO2 CHANGES IN MURINE TUMORS

46 1Lothar Weissfloch, Michael Peller, Juergen Weber, Hans-Juerge nFeldmann, Reingart Senekowitsch-Schmidtke, Karlheinz Tempel, Jeffre yA. Coderre , Michael Molls, and Michael Reiser

MUSCLE OXYGENATION AND METABOLIS M

44. VENOUS-ARTERIOLAR REFLEX IN HUMAN GASTROCNEMIUSSTUDIED BY LAIRS

467Tiziano Binzoni, Loan Ngo, Massimo Girardis, Roger Springett, Francoi sTerrier, and David Delp y

45. MUSCLE OXYGEN CONSUMPTION AT ONSET OF EXERCIS EBY NEAR INFRARED SPECTROSCOPY IN HUMANS

475Takafumi Hamaoka, Toshihito Katsumura, Norio Murase, Takayuk iSato, Hiroyuki Higuchi, Motohide Murakami, Kazuki Esake, Ryotar oKime, Toshiyuki Homma, Akiko Sugeta, Yuko Kurosawa, TeruichiShimomitsu, and Britton Chance

46 . MODELING OF OXYGEN DIFFUSION FROM THE BLOO DVESSELS TO INTRACELLULAR ORGANELLES

485Aleksander S . Pope], Daniel Goldman, and Arjun Vadapall i

47. MUSCLE REOXYGENATION RATE AFTER ISOMETRI CEXERCISE AT VARIOUS INTENSITIES IN RELATIONTO MUSCLE OXIDATIVE CAPACITY

497Ryotaro Kime, Toshihito Katsumura, Takafumi Hamaoka, TakuyaOsada, Takayuki Sako, Motohide Murakami, Sang Yong Bae, Koj iToshinai, Shukoh Haga, and Teruichi Shimomitsu

48. OXYGEN DIFFUSION COEFFICIENT AND OXYGE NPERMEABILITY OF METMYOGLOBIN SOLUTION SDETERMINED IN A DIFFUSION CHAMBER USING ANON-STEADY STATE METHOD

509Jolanda P .W .M . Lamers-Lemmers, Louis J .C . Hoofd, and Beren dOeseburg

49. PINACIDIL-INDUCED OPENING, LIKE GLIBENCLAMIDE-INDUCED CLOSURE OF CARDIAC K ATP CHANNELS ,PROTECTS CARDIAC FUNCTION AGAINS TISCHEMIA IN ISOLATED, WORKING, ERYTHROCYT EPERFUSED RAT HEARTS

51 9Roger J . Legtenberg, Ralph J .F . Houston, Paul Smits, and Berend Oesebur g

50 . EFFECT OF IRRADIATION ON ENZYMES OF THE CAPILLAR YBED IN RAT VENTRICLES

527Ming Gao, Hiroki Shirato, Kazuo Miyasaka, and Tomiyasu Koyama

CRITICAL pO2

51 . THE REDOX STATE OF CYTOCHROME OXYDASE IN BRAIN INVIVO : AN HISTORICAL PERSPECTIVE

53 5Jospeh C . LaManna

52. A QUANTITATIVE STUDY OF OXYGEN AS A METABOLICREGULATOR

54 7Krishnan Radhakrishnan, Joseph C . LaManna, and Marco E . Cabrer a

53. THE OXYGEN DEPENDENCY OF CEREBRAL OXIDATIV EMETABOLISM IN THE NEWBORN PIGLET STUDIEDWITH 3rP NMRS AND NIRS

555Roger J . Springett, Marzena Wylezinska, Ernest B . Cady, Veronica Hollis ,Mark Cope, and David T . Delpy

54. EFFECT OF MYOGLOBIN INACTIVATION ONINTRACELLULAR GRADIENTS OF NADHFLUORESCENCE AT CRITICAL MITOCHONDRIA LOXYGEN SUPPLY

565Eiji Takahashi, Hiroshi Endoh, Mizue Ishikawa, Machiko Kishi,andKatsuhiko Do i

55. EFFECTS OF ANESTHESIA ON CEREBRAL TISSUE OXYGENTENSION: USE OF EPR OXIMETRY TO MAKEREPEATED MEASUREMENTS

569Harold M . Swartz, Satoshi Taie, Minoru Miyake, Oleg Y . Grinberg ,Huagang Hou, Hisham El-Kadi, and Jeff F . Dun n

OXYGEN RELATED GENE ACTIVATIO N

56 . CAPILLARIZATION AND VASCULAR ENDOTHELIAL GROWT HFACTOR EXPRESSION IN HYPERTROPHYINGANTERIOR LATISSIMUS DORSI MUSCLE OF TH EJAPANESE QUAIL

577Hans Degens, Rebecca K . Anderson, and Stephen E . Alway s

57. EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGE NIN RAT HEARTS SUBJECTED TO TRANSIEN TISCHEMIA FOLLOWED BY REPERFUSION

587Tomiyasu Koyama, Zhonglin Xie, Jun'ichi Suzuki, and Kazuhiro Abe

58. FIBROBLAST GROWTH FACTORS (FGFS) INCREASE BREAS TTUMOR GROWTH RATE, METASTASES, BLOO DFLOW, AND OXYGENATION WITHOUT SIGNIFICANTCHANGE IN VASCULAR DENSITY

593Paul Okunieff, Bruce M . Fenton, Lurong Zhang, Francis G . Kern ,Timothy Wu, J. Robert Greg, and Ivan Din g

59 . MECHANISMS OF FGF1 AND VEGF MEDIATED ANGIOGENESI SKHT TUMOR BEARING MICE

60 3Ivan Ding, Weimin Liu, Jianzhong Sun, Scott F . Paoni, Eric Hernady ,Bruce M . Fenton, and Paul Okunieff

60. HIF-la AND VEGF EXPRESSION AFTER TRANSIENT GLOBA LCEREBRAL ISCHEMIA

61 1Paolo Pichiule, Faton Agani, Juan C . Chavez, Kui Xu, . and Joseph C .LaMann a

61. RELATIONSHIP BETWEEN THE GENE EXPRESSION OF C-FO SAND DEGREE OF HYPOXIA IN RAT BRAIN, A SREVEALED BY NEAR-INFRARED SPECTROSCOPY

61 9Yasutomo Nomura, Masataka Kinjo, and Mamoru Tamur a

OXYGEN METABOLISM AND PATHOPHYSIOLOGY

62 . BLOOD VOLUME CHANGES ARE CONTROLLED CENTRALLY ,NOT LOCALLY - A NEAR-INFRARED SPECTROSCOPYSTUDY OF ONE-LEGGED AEROBIC EXERCISE

627Chris E . Cooper and Caroline Angu s

63. A MODELING INVESTIGATION TO THE POSSIBLE ROLE O FMYOGLOBIN IN HUMAN MUSCLE IN NEAR INFRARE DSPECTROSCOPY (NIRS) MEASUREMENTS

63 7Louis Hoofd, Willy Colier, and Berend Oesebur g

64. TISSUE HYPOXIA DURING BACTERIAL SEPSIS I SATTENUATED BY PR-39, AN ANTIBACTERIA LPEPTIDE

645Philip E . James, Melani Madhani, Chris Ross, Linda Klei, Aaro nBarchowsky, and Harold M.Swartz

65. EFFECTS OF THE CONTRAST MEDIUM IOPROMIDE O NRENAL HEMODYNAMICS AND OXYGEN TENSION INTHE DIABETIC RAT KIDNEY

65 3Fredrick Palm, Per-Ola Carlsson, Angelica Fasching, Olof Hellberg,Anders Nygren, Peter Hansell, and Per Lis s

66. POSTOCCLUSIVE REACTIVE HYPEREMIA IN HEALTH YVOLUNTEERS AND PATIENTS WITH PERIPHERA LVASCULAR DISEASE MEASURED BY THRE ENONINVASIVE METHODS

66 1Tomai Jarm, Rudi Kragelj, Aadam Liebert, Piotr Lukasiewitz, Tatjan aErjavec, Marketa Preleren-Strukel, Roman Maniewski, Pavle Poredos ,and Damijan Miklavi ii;

67. ROLE OF MYOGLOBIN IN REGULATING RESPIRATION

67 1Thomas Jue and Youngran Chun g

68 . OXIDATIVE DEFENSES IN THE SEA BASS, DICENTRARCHUSLABRAX

681.Giulia Guerriero, Alessandra Di Finizio, and Gaetano Ciarci a

69. RHEOLOGIC DISSIMILARITIES IN FEMALE AND MAL EBLOOD : POTENTIAL LINK TO DEVELOPMENT OFCARDIOVASCULAR DISEASES

689Marina V . Kameneva, Mary J . Watach, and Harvey S . Borovetz

70. PRELIMINARY STUDIES OF THE APPLICATION OF NEA RINFRARED SPECTROSCOPY IN THE DIAGNOSIS OFDEEP VEIN THROMBOSIS

697Lino K . Korah, Frederick D. Scott, G . Melville Williams, and Kyung A .Kan g

71. CEREBROVASCULAR RESPONSE TO ACUTE METABOLI CACIDOSIS IN HUMANS

707Marjo J .T . Van de Ven, Willy N .J .M . Colier, Bregina T .P . Kersten ,Berend Oeseburg, and Hans Folgerin g

72 . FREE FLAP MONITORING IN PLASTIC AN DRECONSTRUCTIVE SURGERY

71 7John A . Pickett, Maureen S . Thorniley, Nigel Carver, and Deric P . Jones

73 . INHIBITION OF MITOCHONDRIAL RESPIRATION DURINGEARLY STAGE SEPSIS

72 5Nathan A . Davies, Chris E. Cooper, Ray Stidwill, and Mervyn Singe r

AUTHOR INDEX

73 7

SUBJECT INDEX

741