Tulane University Department of Pathology & Laboratory Medicine Winter 2014 Newsletter
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TULANE UNIVERSITY HEALTH SCIENCES CENTER DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE PATHWAYS MESSAGE FROM THE CHAIRMAN NEWSLETTER VOLUME 4, ISSUE 2 WINTER 2014 Dear Colleagues: As the Department of Pathology reaches mid-academic year, we can col- lectively look back over the summer and fall months with a sense of pride in the accomplishments of faculty, fellows and residents. Our re- search activities continue to be robust. Two of our faculty members were awarded R01 grants from the NIH; a number of our research fellows and graduate students received awards and recognition for their excel- lent work presented at national meetings. Another graduate student was awarded a NIH F31 fellowship. Our residency program continues to evolve as we witnessed the residents’ clinical commitment, their presen- tations at national meetings and their strong leadership roles. We wel- comed two new faculty members to the team and are awaiting the arrival of three more. These past six months also brought a wealth of knowl- edge to our Department in the form of several invited guest speakers who enriched us with their expertise. Our diagnostic pathology service remains consistent and strong as does our commitment to providing the finest teaching to students, residents and fellows. With the goal to even surpass these accomplishments, the Pathology Department will continue striving to achieve more excellence and growth over the coming months. Best wishes,
Transcript
TULANE UNIVERSITY HEALTH SCIENCES CENTER
DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE
PATHWAYS
MESSAGE FROM THE CHAIRMAN
NEWSLETTER VOLUME 4, ISSUE 2 WINTER 2014
Dear Colleagues:
As the Department of Pathology reaches mid-academic year, we can col-
lectively look back over the summer and fall months with a sense of
pride in the accomplishments of faculty, fellows and residents. Our re-
search activities continue to be robust. Two of our faculty members
were awarded R01 grants from the NIH; a number of our research fellows
and graduate students received awards and recognition for their excel-
lent work presented at national meetings. Another graduate student was
awarded a NIH F31 fellowship. Our residency program continues to
evolve as we witnessed the residents’ clinical commitment, their presen-
tations at national meetings and their strong leadership roles. We wel-
comed two new faculty members to the team and are awaiting the arrival
of three more. These past six months also brought a wealth of knowl-
edge to our Department in the form of several invited guest speakers
who enriched us with their expertise. Our diagnostic pathology service
remains consistent and strong as does our commitment to providing the
finest teaching to students, residents and fellows. With the goal to even
surpass these accomplishments, the Pathology Department will continue
striving to achieve more excellence and growth over the coming months.
Best wishes,
Dr. Srikanta Dash, Professor of Pathology,
(seen right) was awarded two RO1 Grants
from the NIH for his applications, IL-28B
genotype and HCV treatment clearance
($1.4 million), and for Hepatitis C and Hepa-
tocellular Carcinoma ($1.2 million). Major
grant goals of both projects
target research on HCV
treatment, and treatment resistance.
************************************************
A member of the Dash Laboratory, Dr. Par-
tha Chandra (left) was honored by the
American Association for the Study of Liver
Diseases (AASLD) Meeting last November at
their 64th annual gathering in Washington,
DC. Dr. Chandra received The Edmund J.
Bini HCV Travel Award for his abstract, Persistently in-
fected hepatitis C virus cell culture impairs type I but not
the type III IFN signaling. The award was presented to Dr.
Chandra at the November 2, 2013 reception. With Dr.
Chandra as first author, the full paper has just been pub-
lished in the American Journal of Pathology.
PATHWAYS NEWSLETTER WINTER 2014 PAGE 2
RESEARCH NEWS
Dr. Partha
Chandra
Dr. Srikanta
Dash
PATHWAYS NEWSLETTER WINTER 2014 PAGE 3
RESEARCH NEWS (CONTINUED)
- Dr. Erik Flemington (left) was awarded a NIH
R01 Grant entitled, Epstein-Barr virus antisense
transcription. The grant will provide $250,000 for
annual direct costs over the next five years...Dr.
Zhen Lin, (below, right) who works in the Fleming-
ton Laboratory, was awarded a Louisiana Clini-
cal and Translational Science Center (LA-CATS)
grant for his work, Analysis of the pathogenesis
of HIV/EBV associated DLBCL...Christina
O’Grady, (below, left) a graduate student in the
Flemington Lab, was awarded a NIH F31 fellow-
ship. She is also first author on a paper pub-
lished in J Virology entitled, Global bidirectional
transcription of the Epstein-Barr virus genome
during reactivation...Michael Strong, (below,
right) also a graduate student in the Flemington Lab, is first author
on a paper published in J Virology entitled, Epstein-Barr virus and
human herpes virus 6 detection in a non-Hodgkins diffuse large B-
cell lymphoma cohort using RNA sequencing. He is also a recipient
of the NIH F31 fellowship award.
RESEARCH NEWS (CONTINUED)
- Also achieving success at the AASLD annual meeting were Xi-
mena Vanegas Qadir and Lu Lu, graduate students who work in
the Wu Laboratory. They presented two separate posters that each
won the AASLD Presidential Poster of Distinction Award. Both
were published as abstracts in the journal Hepatology. Members
of the Wu Lab participated in presenting a total of four posters
that represented the collaborative efforts of Drs. Tong Wu, Chang
Han, Kyoung-Sub Song, and Jinqiang Zhang with graduate stu-
dents Qadir and Lu.
PATHWAYS NEWSLETTER WINTER 2014 PAGE 4
Graduate Student Ximena Vanegas Qadir
(above, right) with award winning poster
at the 64th Annual AASLD Meeting held
last November in Washington, DC.
Lu Lu, graduate
student and pre-
senter of award-
winning poster at
AASLD Meeting.
RESIDENTS’ CORNER
NEWS, ACCOMPLISHMENTS, MILE-
STONES
Dr. Janet Schmid (seen above), Associate Professor of Pathology
and Director of the Residency Program, reports... twenty-seven
(27) excellent applicants were interviewed to fill resident positions
opening in the July 2014 program...the Residency Education
Committee will spend the winter and spring months of 2014 busily
developing a plan to implement the new ACGME pathology training
milestones for 2014...Dr. Sharon Hirsh completed her pathology
training on 11/15/13 and is now working at the Thyroid Cytopa-
thology Partners in Austin, TX…Dr. Kim Mayhall is first author of
the published paper: A thirty-five-year-old woman with gastric sig-
net ring cell carcinoma secondary to the Chernobyl nuclear accident:
a case report, published in Case Reports in Oncology, 2013 March
21, and the abstract Overexpression of SirT3 and nicotinamide
phosphoribosyltransferase in melanoma published in Archives of
Pathology and Laboratory Medicine, 2013 October.
PATHWAYS NEWSLETTER WINTER 2014 PAGE 5
RESIDENT’S CORNER (CONTINUED)
POSTER PRESENTATIONS
Over the fall months, several residents were busy with the creation
and presentation of posters at the
CAP Annual Meeting (October 13,
2013) in Orlando, FL; the American
Society of Dermatopathology An-
nual Meeting (October 10-13, 2013) in
Washington, DC; the American So-
ciety of Clinical Pathologists An-
nual Meeting in Chicago, IL, and
the American Society of Cytopa-
thology in Orlando, FL. Presenters at
the CAP Meeting included Dr. Kim “Greg” Mayhall (above right)
and Dr. Laura Bratton (below left). Dr. Sharon Hirsh (below right)
presented at the American Society of Cytopathology Annual Meet-
ing.
PATHWAYS NEWSLETTER WINTER 2014 Page 6
PATHWAYS NEWSLETTER WINTER 2014 PAGE 7
RESIDENTS CORNER (CONTINUED)
EXCELLENCE IN LEADERSHP
Six Department of Pathology residents have assumed leadership
roles in various capacities at Tulane.
- Dr. Buu Duong (PGY III) is the President of the Tulane Resident
and Fellows Congress while also serving as a member of the CAP
Resident Executive Committee.
- Dr. Laura Bratton (PGY III) serves as both the Chair of the Social
Committee, Tulane Fellow and Resident Congress, and as an ASCP
Resident Representative.
- Dr. Greg Mayhall (PGY III) serves as a Representative on the CAP
Resident Forum.
- Dr. Evans Roberts (PGY II) is a Department Resident Represen-
tative, Tulane Resident and Fellow Congress.
- Dr. John Scopetta (PGY II) is a member of the Pathology Resi-
dent Education Committee.
- Dr. Ronnie Self (PGY IV), Chief Resident, is a Junior Ad Hoc
Member of the Public Affairs and Advocacy Committee of the
American Society of Cytopathology.
Dr. Buu Duong PGY III,
President of the Tulane
Resident and Fellows Con-
gress.
GUEST SPEAKERS
- The Department of Pathology and Labora-
tory Medicine was honored by visits from
several distinguished guest speakers. For-
mer Tulane Medical School alumnus, Dr.
Mary Beth Beasley visited her alma mater
from October 24-25, 2013. Dr. Beasley,
now an Associate Professor of Pathology
and Head of Pulmonary Pathology at
Mount Sinai Hospital in New York, gave a resident slide review en-
titled, Update on Interstitial Lung Disease—What’s New Since 2002.
Following her Pathology Grand Rounds seminar, Lung Cancer Di-
agnosis—Pitfalls and Priorities,” Dr. Beasley then conducted a di-
dactic conference on Problematic Pleural Pathology.
- Co-sponsored with the Office of Academic Affairs
and Provost Networking Seminar series, Dr. Chen
Dong, Associate Professor in the Department of
Immunology and Director of the Center of Inflam-
mation and Cancer, University of Texas, MD
Anderson Cancer Center, gave a Grand Rounds
seminar on October 4, 2013. Dr. Dong spoke on,
Regulation and Function of TH17 Cells in Inflam-
mation and Cancer.”
Dr. Mary Beth
Beasley
Dr. Cheng Dong
PATHWAYS NEWSLETTER WINTER 2014 PAGE 8
GUEST SPEAKERS (CONTINUED)
-On December 6, 2013, the Pathology Depart-
ment hosted Grand Rounds guest speaker invitee,
Dr. Ji Suk Chang. Dr. Chang, an instructor and
COBRE Project Principal Investigator at Baton
Rouge’s Pennington Biomedical Research Center,
spoke on, Regulation of Adaptive Thermogenesis
by the Short Isoform of PGC-I Alpha.
THE STERNBERG-REED LECTURE SERIES
- The third annual Sternberg- Reed Lecture Se-
ries was held December 12—13, 2013. Dr.
Christopher Crum, a professor of Pathology at
Harvard Medical School and Director of the Di-
vision of Women’s and Perinatal Pathology,
Brigham and Women’s Hospital, Boston, MA,
interacted with faculty and residents. Conduct-
ing two separate resident slide reviews entitled,
Diagnostic Problems in Gynecologic Pathology,
Parts I and II, Dr. Crum delivered the annual
lecture speaking on, Origins of Gynecologic Can-
cer: Discovery and Application.
Dr. Ji Suk Chang
Dr. Christopher
Crum
PATHWAYS NEWSLETTER WINTER 2014 PAGE 9
WELCOME NEW FACULTY
Dr. Suzana Savkovic joins us as a new Associate Professor in the
Department of Pathology and Laboratory Medicine. Having re-
ceived her B.S. degree in Molecular Biology and
Genetics Engineering at the University of Bel-
grade in Serbia, Dr. Savkovic then received her
Ph.D. from both the University of Belgrade and
the University of Illinois at Chicago. Just before
joining Tulane, Dr. Savkovic worked as an Assis-
tant Professor at the Northshore University
Health System in Evanston, IL. Dr. Savkovic
whose research areas are centered on metabo-
lism and colon carcinogenesis, joins us as the re-
cipient of an RO1 Grant awarded by the NIH.
Dr. Savkovic has published twenty-five articles in high-impact,
peer-reviewed journals and has been the recipient of several aca-
demic and professional awards.
The Pathology Department also welcomes Dr. Andrew Sholl as a
new Assistant Professor. In addition to teaching students and
appointed to the rank of Assistant Adjunct Profes-
sor of Pathology.
- Farewell to Dr. Meredith Lakey who left her full
time appointment but remains on staff as an As-
sistant Adjunct Professor.
- Farewell to Dr. Dongdong Lu who leaves the Wu Laboratory af-
ter four years to return home to his native
China.
- Welcome to Daniel Hoskins who joins us
as our Grant Management Analyst.
Dr. Haitao
Zhang
Daniel Hoskins,
Grant Management
Analyst
PATHWAYS NEWSLETTER WINTER 2014 PAGE 11
PUBLICATIONS
Lu DD, Han C, Wu T. 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interac-tion with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins. J Biol Chem. 2013 Jul 5;288(27): 19484-19502. PMID: 23687300
Panigrahi R, Hazari S, Chandra S, Chandra PK, Datta S, Kurt R, Cameron CE, Huang Z, Zhang H, Garry RF, Balart LA, Dash S. Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS One. 2013 Aug 23;8(8):e72791. PMID: 24009705
Shackelford R, Hirsh S, Henry K, Abdel-Mageed A, Kandil E, Coppola D. Nicotinamide phosphoribosyltransferse and SirT3 expressions are increased in well-differentiated thyroid carcinomas. Anticancer Res. August 2013 33(8): 3047-3052.
Gordon M, El-Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, Mohamed A, El-Kadi Ao, Liu L, Onyskiw C, Ghazaleh HA, Park J, Lee SB, Yu VC, Fernandez-Patron C, Alexander RT, Wine E, Bakash S. The tumor suppressor gene, RASS-F1A, is essential for protection against inflammation-induced injury. PLoS One. 2013 Oct 16;8(10):e75483. PMID: 24146755
Dash S, Chandra P, Ramaza K, Garry R, Balart L. Mechanisms of hepatitis C virus clearance by interferon and ribavirin combination: lessons learned from in Vvtro cell culture. Book chapter: Cancer Causing Viruses and Their Inhibi-tors, Gupta S editor. Textbook, CRC Press Publishing Company, 2013.
Whitling N, Shanesmith R, Jacob L, McBurney E, Sebastian S, Wang E, Wang A. Composite lymphoma of mycosis fungoids and cutaneous small B-cell lym-phoma in a 73-year-old male patient. Human Pathology 2013;44(4): 670-675.
Song K, Han C, Zhang J, Lu D, Dash S, Feitelson M, Lim K, Wu T. Epigenetic regulation of miR-122 by PPARgamma and hepatitis B virus X protein in hepato-ceullar carcinoma cells. Hepatology 2013 Nov: 58)5): 1681-92.
Mayhall K, Ghayouri M, Henry K, Margin V, Copolla D. Shackelford R. A thirty-sive-year-old woman with gastric signet ring cell carcinoma secondary to the Chernobyl nuclear accident: a case report. Case Reports in Oncology, 2013 March; 6(1):158-62.
PATHWAYS NEWSLETTER WINTER 2014 PAGE 12
PATHWAYS NEWSLETTER WINTER 2014 PAGE 13
PUBLICATIONS (CONTINUED) .
Whitling N, Shanesmith R, Jacob L, McBurney E, Sebastian S, Wang E, Wang A. Composite lymphoma of mycosis fungoids and cutaneous small B-cell lym-phoma in a 73-year-old male patient. Human Pathology 2013;44(4): 670-675.
Song K, Han C, Zhang J, Lu D, Dash S, Feitelson M, Lim K, Wu T. Epigenetic regulation of miR-122 by PPARgamma and hepatitis B virus X protein in hepato-ceullar carcinoma cells. Hepatology 2013 Nov: 58)5): 1681-92.
Alraiyes AH, Kheir F, Hirsh S, Salerno S, Bernal-Green LY, Daroca P. A 40-Year-Old Woman with Multiple Lung Nodules. Chest. 2013;143 (6): PMID: 23732596
Abd Elmageed ZY, Moroz K, Kandil E. Clinical significance of CD146 and latexin during different stages of thyroid cancer. Mol Cell Biochem. 2013 Sep 381(1-2):95-103. PMID: 23712706
Kook S, Cho J, Lee SB, Lee BC. The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells. J Clin Invest. 2013 Aug 1;123(8):3420-35.PMID: 23863713
Abd Elmageed ZY, Moroz K, Srivastav SK, Fang Z, Crawford BE, Moparty K, Thomas R, Abdel-Mageed AB. High circulating estrogens and selective expres-sion of ERβ in prostate tumors of Americans: implications for racial disparity of prostate cancer. Carcinogenesis. 2013 Sep;34(9):2017-2023. PMID: 23658372
Bhandary YP, Shetty SK, Marudamuthu AS, Ji HL, Neuenschwander PF, Bog-gram V, Morris GF, Fu J, Idell S, Shetty S. Regulation of lung injury and fibro-sis by p53-mediated changes in urokinase and plasminogen activator inhibito1. Am J Pathol. 2013 Jul;183(1): 131-143. PMID: 23665346.
Gunduz F, Malikarjun C, Balart LA, Dash S. Interferon alpha induced intra-hepatic pSTAT1 inversely correlates with serum HCV RNA levels in chronic HCV infection.. Exp Mol Pathol. 2013 Nov 8. PMID: 24211829
Bao L, Chandra PK, Moroz K, Zhang X, Thung SN, Wu T, Dash S. Impaired autophagy response in human hepatocellu- lar carcinoma. Exp Mol Pathol. 2013 Dec 23. PMID: 24369267
Park JH, Kang HJ, Sang SI, Lee JE, Hur J, Ge K, Mueller E. Li H, Lee S. A multifunctional protein, EWS, is essential for early brown fat lineage determina-tion. Dev Cell. 2013 August 26;26 (4):393-404 PMID 23987512
PATHWAYS Newsletter WINTER 2014 Page 14
PUBLICATIONS (CONTINUED)
Park BH, Kook S, Lee S, Jeong JH, Brufsky A, Lee BC. An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration. J Biol Chem. 2013 Oct 4;288(40):28656-67. PMID: 23966000
Zhang W, Edwards A, Flemington E, Zhang K. Inferring polymorphism-induced regulatory gene network active ni human lymphocyte cell lines by weighted linear mixed model analysis lysis of multiple RNA-Seq Datasets. PLosOne. 2013 Oct 30;8(10):e7886 PMID: 24205334
Zhan Y, Cao B, Qi Y, Liu S, Zhang Q, Zhou W, Xu D, Lu H, Sartor O, Kong W, Zhang H, Dong Y.Methylselenol prodrug enhances MDV3100 efficacy for treat-ment of castration-resistant prostate cancer. Int J Cancer. 2013 Nov;133(9): 2225-2233. PMID: 23575870
Feng Z, Zhang Z, Wu XC Lifetime risk of cutaneous melanoma by histological subtype and race/ethnicity in the United States. J La State Med Soc. 2013 Jul-Aug; 165(4): 201-208. PMID: 24133782
Strong MJ, O’Grady T, Lin Z, Xu g, Baddoo M, Parsons C, Zhang K, Taylor CM, Flemington EK. Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin’s diffuse large B-cell lymphoma cohort using RNA-seq. J Virol. 2013 Dec; 87(23): 13059-62. PMID: 24049168
OTHER CONTRIBUTIONS
Mayhall KG, Crawford BD.Systemic coccidiodomycosis. College of American Pathologists (CAP), Performance Improvement Program, (PIP). September 2013
Lakey M, Crawford BD. Signet Ring Cell Lymphoma. College of American Pa-thologists (CAP), Performance Improvement Program (PIP). October 2013
Crawford BE. Fibrosing Variant of Hashimoto’s Thyroiditis. College of Ameri-can Pathologist (CAP) Performance Improvement Program (PIP). September 2013
PRESENTATIONS
Wu Y, Cui A, Zhou X, Wang WH, Yao NN, Li HW, Han C, Wu T, Li GY. The single-chain antibody blocking cyclooxygenase-2 activity inhibits the growth of hepatocellular carcinoma. (Poster presentation) Hepatology 2013, 58(4): 1064A. The 64th Annual Meeting of the American Association for the Study of Liver Diseases, Washington, DC. November 1 - 5, 2013.
Zhang JQ, Han C, Song KS and Wu T. lncRNA MALAT1 inhibits Smad2/3 sig-naling in hepatic cells (Oral presentation). Hepatology 2013, 58(4): 235A: The 64th Annual Meeting of the American Association for the Study of Liver Dis-eases, Washington, DC. November 2-5, 2013.
Qadir XV, Han C and Wu T. MiR-223 deficiency prevents Fas-induced liver in-jury through activation of IGFR1. (Poster presentation) Hepatology 2013, 58(4): 346A.The 64th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD Presidential Poster of Distinction), Washington, DC. November 1 - 5, 2013.
Lu L, Han C and Wu T. MicroRNA-21 targets NAD+-linked 15 Hydroxypros-taglandin dehydrogenase (15-PGDH) and promotes cholangiocarcinoma growth. (Poster presentation) Hepatology 2013, 58(4): 1061A. The 64th Annual Meet-ing of the American Association for the Study of Liver Diseases (AASLD Presidential Poster of Distinction), Washington, DC. November 1 - 5, 2013.
Duong B, Bratton L, Self R, Whitling N, Wang A. Nevus comedonicus of labia majora. American Society of Dermatopathology Annual Meeting; October 10-13, 2013. Washington, DC.
Hirsh S and Shackelford R. “Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated Thyroid carcinomas”. American Society of Clinical Pathologists (ASCP) Annual Meeting 2013, Chi-cago, Illinois, USA.
McNaughton, J, Mayhall G., Schmid, J. Red blood cell transfusion and red blood cell exchange transfusion. Sickle Cell Education Day, Tulane’s Sickle Cell Center of Excellence, September 2013, New Orleans, LA.
Meng, X, Whitling N, Duong B, Wang, A. Mitosis-phase index in cutaneous malignancy. American Society of Dermatopathology Annual Meeting; October 10-13, 2013, Washington, DC.
PATHWAYS NEWSLETTER WINTER 2014 PAGE 15
PRESENTATIONS (CONTINUED)
Bratton L, Wysocki J, Shores N, Kimbrell H. Mixed large cell neuroendocrine carcinoma and adenocarcinoma with spindle cell and clear cell features in the extrahepatic bile duct: clinicopathologic correlation and review of the literature [poster]. CAP Annual Meeting October 13, 2013, Orlando FL
Hirsh S, Roberts E, Lacey M, Torrellas-Ruize N, Goswami M, Kimbrell H, Moroz K. The role of obesity in cytologic risk factor assessment of suspicious thyroid nodules. 2013 American Soceity of Cytopathology 61st Annual Meet-ing; November 8—12, 2013, Orlando, FL.
Duong T, Shackelford R, Wang A. A fatal drug reaction with eosinophilia and systemic symptoms (DRESS) induced by allopurinol. American Society of Der-matopathology Annual Meeting; October 10—13, Washington, DC
