Pathways Winter 2015

TULANE UNIVERSITY HEALTH SCIENCES CENTER

DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE

PATHWAYS

MESSAGE FROM THE CHAIRMAN

NEWSLETTER VOLUME 5, ISSUE 1 WINTER 2015

Dear Colleagues:

Taking a thoughtful and retrospective look at the past twelve months

that comprise the year 2014, it is gratifying to see that the Department

of Pathology has met many challenges and accomplished a number of

goals. In the midst of this, we said goodbye to a departed and respected

faculty member, Dr. Suzanne Meleg-Smith. As we remember our loss, we

also remember our achievements in the scope of clinical services, re-

search and teaching. We welcomed three new clinical faculty members

who bring new expertise to our existing strengths. The past year also

saw the graduation of several residents and fellows. We welcomed three

new Fellows and three PGY I residents. Our residents are committed and

dedicated to their learning and services while maintaining strong leader-

ship roles in the School. Four graduate students completed their disser-

tation studies and received their Ph.D. degrees. Our research activities

are diverse and robust, as reflected by the extramural grant support and

the high quality of publications. As 2015 dawns, the Department meets

this new year already strengthened by the achievement of the preceding

year; the challenges represented by this new year are to exceed the

achievements of the previous year. Not only are we committed to main-

tain an excellent standard of clinical, research and teaching accomplish-

ments, it is our goal to surpass it. Warmest wishes for a successful

2015!!

The 2013-2014 Resident/Fellow Graduation reception was held

last May at Pat Os on the River. Dr. Tong Wu, Chairman, pre-

sented the Outstanding Graduate Student Award to Ximena Qadir.

Dr. Erik Flemington bestowed the same Award to Christina

OGrady. Drs. Partha Chandra received The Outstanding Post

Doctoral Fellow Award from Dr Srikanta Dash; Dr. Xichun Liu re-

ceived the same award from Dr. Haitao Zhang.

Dr. Janet Schmid, Director of the Pathology Residency Program,

presented graduating fellow Dr. Zhuang Feng a certificate and

book; the same tribute was paid to graduating fellow Dr. Janet

McNaughton who could not be present. Dr Ronnie Self II, AP/CP

Resident and Chief Resident likewise received a graduating certifi-

cate and book from Dr. Schmid.

PATHWAYS NEWSLETTER WINTER 2015 PAGE 2

2014 COMMENCEMENT CEREMONY

Clockwise from top:

Drs. Dash; Chandra;

Zhang; Liu; Schmid;

Feng. Bottom from left:

Dr. Flemington; Ms.

OGrady; Drs. Schmid

and Self.

During the Commencement ceremony, the late Dr. Suzanne Meleg-

Smith, Head, Autopsy Service, Head, Renal Service, honored Drs.

Meggie Doucet and Eleanor Lewin by bestowing upon them the

Rokitansky Award for Excellence in Autopsy Pathology.

The Richard J. Reed Award for Surgical Pathology was given to Dr.

Zhuang Feng by Dr. Philip Daroca.

Dr. Wu announced that Dr. Krzysztof Moroz won the Pathology

Teaching Award. Dr. Moroz could not be present.

Chief Resident Dr. Ronnie Self presented the Philip J. Daroca

Award for Residency Education to Dr. Suzanne Meleg-Smith.


COMMENCEMENT (CONTINUED)

Clockwise from top: Drs. Lewin; Smith;

Doucet; Darcoa; Feng; Moroz. Bottom

from left: Drs. Self and Meleg-Smith

Michael Strong, (below, right ) a graduate student in the Fleming-

ton Lab, was selected to receive the 2015 American Association of

Neurological Surgeons (AANS) Young Neurosurgeons Committee

Mission Fellowship... Dr. Rajesh Panigrahi (below, left) presented

the poster, Persistently infected HCV cell culture impairs RBV antivi-

ral activity through clathrin mediated trafficking of ENT1 at the

AASLD Conference in Boston in November 2014. Virology. ac-

cepted it for publication

Not featured here are a number of other fellows/residents/

students who presented their works at national meetings (see Pres-

entations).

.


RESEARCH NEWS


NEW POST DOCTORALS

Lu Lu, Ph.D, (above left), Ximena

Vanegas Qadir, PhD. (above, right),

and Hanqing Zhu, Ph.D. (below, left),

all former graduate students in the

Wu Lab, received their Ph.D. degrees

in 2014. Dr. Lu is currently working

in China; Dr. Qadir is employed by

the NIH in Bethesda, MD; Dr. Zhu

works in the Wu Lab at Tulane.

(continued next page.)

RESEARCH NEWS (CONTINUED)


RESEARCH NEWS (CONTINUED)

BeiBei Xhu, Ph.D. (left), a former-

graduate student who worked in

the Morris Laboratory, success-

fully defended her dissertation

and received her Ph.D. degree in

2014. Dr. Xu now works with Dr.

Franck Mauvis-Jarvis in the En-

docrinology section of Tulane.

Subing Cao, Ph.D. (right), a

former graduate student

who worked in the Fleming-

ton Laboratory, received her

Ph.D.in 2014. Working with

Dr. Yan Dong, Dr. Cao has

remained at Tulane

RESIDENTS CORNER

NEWS, ACCOMPLISHMENTS,

MILESTONES

Dr. Janet Schmid (seen above), Associate Professor of Pathol-

ogy and Director of the Residency Program, reports: Former Fel-

low Dr. Zhuang Feng joined Oregon Health & Sciences University

to work as a Hematopathology Fellow...Dr. Janet McNaughton, a

former Cytopthology Fellow, will join the Pathology Professional

Practice of Columbia, SC this July...Dr. Ronnie Self, former Chief

Resident, joined the Department of Pathology at Leonard J.

Chabert Medical Center in Houma, LA43 excellent resident

candidates were interviewed in the Resident Recruitment process.


NEW FELLOWS AND RESIDENTS

PATHWAYS NEWSLETTER WINTER 2015 Page 8

ABOVE: Welcome to new Fellows. From left to right: Dr. Janet Herfel

(Cytopathology Service ); Dr,.Michael Lee (Dermatopathology Service )

and Dr. Thad Primeaux (Hematopathology Service ).

ABOVE: Welcome to new Residents. From left to right: Dr. Jeremy

Atkinson, Dr. Lucas Rifkin and Dr. Darshan Trivedi, all PGY Is.

2014-2015

Co-Chief Residents

Drs. Lacey Sullivan

(left) and Dr. Buu

Duong ( right).

GUEST SPEAKERS

During 2014, the Department of Pathology

and Laboratory Medicine was honored by

visits from several distinguished guest

speakers.

Dr. Daphne Bell, an Investigator at the

Reproductive Cancer Genetics & Genomics

Branch of the National Institutes of Health

(NIH), gave a Grand Rounds presentation

entitled, Uncovering Driver Mutations in

Clinically Endometrial Carcinomas: last September.

Dr. Jay K. Kolls, Director of the Richard King

Mellon Foundation Institute for Pediatric Re-

search, and a Professor of Pediatrics at the

University of Pittsburgh School of Medicine,

delivered a Grand Rounds Presentation. His

lecture, Type 17 Immunity at the Mucosa,

was presented to the Department last Novem-

ber.

Dr. Daphne Bell

Dr. Jay K. Kolls


GUEST SPEAKERS (CONTINUED)

Last December, Dr. Chen Liu was a guest Grand Rounds presenter. Dr. Liu, Professor

and Associate Chairman of the Department of

Pathology, Immunology and Laboratory Medi-

cine, University of Florida College of Medicine

at Gainesville, gave a talk on Liver Cancer in

the Era of Personalized Medicine.

In conjunction with Tulanes Research Days,

the annual Dr. & Mrs. Michael A. Gerber Memo-

rial Lecture was delivered by guest speaker, Dr.

Markus Grompe. Dr. Grompe, whose topic was,

Cell Therapy for Liver Diseases: Hepatocytes

vs. Stem Cells, is the Ray Hickey Chair and Di-

rector of the Pape Family Pediatric Research In-

stitute, Oregon Stem Cell Center at the Oregon

Health and Science University.

Dr. Chen Liu

DR. MARKUS

GROMPE


DR. & MRS. MICHAEL A. GERBER

MEMORIAL LECTURE

WELCOME NEW FACULTY

Yukihiro Nakanishi, M.D., Ph.D. (below, right), joins the Depart-

ment of Pathology and Laboratory Medicine as an Assistant Profes-

sor who will specialize in gastrointestinal pathology and surgical

pathology. Dr. Nakanishi received both his

M.D. and Ph.D. degrees from Japans

Gumma University School of Medicine. He

was a resident in pathology at the National

Cancer Center Research Institute and Hos-

pital, Tokyo, Japan. Following his resi-

dency training in surgical pathology, he

served as staff, then as section head of the

pathology division of the National Cancer

Center Research Institute and Hospital, Tokyo, Japan. Dr. Naka-

nishi then worked as a Visiting Fellow in the Department of Pa-

thology at UCLA School of Medicine. From there he went on to

work as a Research Fellow in the Department of Pathology at Mas-

sachusetts General Hospital. He has also worked as a Resident in

Anatomic Pathology at St. Louis University Medical Center and as

a Fellow in Oncological Surgical Pathology at Roswell Park Cancer

Institute. Dr. Nakanishi, who joins us after serving as a Fellow in

Gastrointestinal Pathology at the Indiana University School of

Medicine, has coauthored more than 150 papers published in the

English language. Dr. Nakanishi is board certified in Anatomic Pa-

thology and he will provide diagnostic services in GI and surgical

pathology.


WELCOME NEW FACULTY (continued)

Ramesh Bhagat, M.D. (seen right) joins the

Department as a Hematopathologist and

surgical pathologist at the rank of Assistant

Professor. Dr. Bhagat received his B.A. de-

gree in biochemistry from Occidental College

in Los Angels, CA, graduating Magnum Cum

Laude. He received his medical degree from the University of Texas

Southwestern Medical School at Dallas where he also completed a

residency in Anatomic and Clinical Pathology. Before joining our

Department, Dr. Bhagat completed his Hematopathology fellowship

at the Methodist Hospital in Houston, TX.

Laura Kidd, M.D. (below, left) joins the Department of Pathology

and Laboratory Medicine as Assistant Professor and serves as a re-

nal pathologist and surgical pathologist. Dr. Kidd received her

B.S. degree in Biomedical Engineering at Louisiana Tech Univer-

sity, Ruston, LA, graduating Summa Cum Laude. She then re-

ceived her medical degree from the University of Mississippi Medi-

cal Center at Jackson. Dr. Kidd completed

her residency and fellowship at the University

of Texas at Health Sciences Center, Houston

TX, where she also served as Chief Resident.

Dr. Kidd joins us from the same institution

where she has worked as a Renal Pathology

Fellow/Clinical Instructor. Board certified in

Anatomic and Clinical Pathology, Dr. Kidds

area of expertise includes renal pathology and

surgical pathology.


Tong Wu, M.D., Ph.D,Chairman

Byron Crawford, M.D.,Vice-Chairman

The Department of Pathology and

Laboratory Medicine

1430 Tulane Avenue Phone: 504-988-5224

Fax: 504-988-7862

Editor: Jeanne Frois

( [email protected])

DEPARTMENT NEWS

- Farewell to Dr. Hillary Kimbrell who relocated to Utah.

- Welcome to Samantha Hoekstra who joins the Department as

an Administrative Secretary..

Samantha Hoekstra,

Administrative Secretary


PUBLICATIONS

Cao S, Strong MJ, Wang X, Moss WN, Concha M, Lin Z, O'Grady T, Baddoo M, Fewell C,

Renne R, Flemington EK. High-throughput RNA sequencing-based virome analysis of 50

lymphoma cell lines from the Cancer Cell Line Encyclopedia project. J Virol. 2015 ;89

(1):713-29. PMID: 25355872

Grieshaber E, Nicotri T, Reina R, Rupley K, Wang A. Cutaneous embolization of doxorubi

cin drug-eluting beads. JAMA Dermatol. 2014 Oct;150(10):1118-20. PMID: 24989853

Xu B, Guenther JF, Pociask DA, Wang Y, Kolls JK, You Z, Chandrasekar B, Shan B,

Sullivan DE, Morris GF.Promotion of lung tumor growth by interleukin-17. Am J Physiol

Lung Cell Mol Physiol. 2014 Sep 15;307(6):L497-508. PMID: 25038189

Martin EC, Krebs AE, Burks HE, Elliott S, Baddoo M, Collins-Burow BM, Flemington EK,

Burow ME.miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line

leads to enhanced mitogen activated protein kinase signaling. Genes Cancer. 2014

Sep;5(9-10):353-64. PMID: 25352952

Sabahi A, Uprichard SL, Wimley WC, Dash S, Garry RF. Unexpected structural features

of the hepatitis C virus envelope protein 2 ectodomain. J Virol. 2014 Sep;88(18):10280-

8. doi: 10.1128/JVI.00874-14. Epub 2014 Jul 2. Review. PMID: 24991010

Egan A, Dong Y, Zhang H, Qi Y, Balk SP, Sartor O. Castration-resistant prostate cancer:

adaptive responses in the androgen axis. Cancer Treat Rev. 2014 Apr;40(3):426-33.

PMID: 24139549

Liu J, Boonkaew B, Arora J, Mandava SH, Maddox MM, Chava S, Callaghan C, He J,

Dash S, John VT, Lee BR. Comparison of Sorafenib-Loaded Poly (Lactic/Glycolic) Acid

and DPPC Liposome Nanoparticles in the in Vitro Treatment of Renal Cell Carcinoma. J

Pharm Sci. 2015 Jan. PMID: 25573425



PUBLICATIONS (CONTINUED)

Cao B, Qi Y, Zhang G, Xu D, Zhan Y, Alvarez X, Guo Z, Fu X, Plymate SR, Sartor O,

Zhang H, Dong Y. Androgen receptor splice variants activating the full-length receptor in

mediating resistance to androgen-directed therapy. Oncotarget. 2014 Mar 30;5(6):1646-

56.PMID: 24722067

Wysocki J, Agarwal R, Bratton L, Nguyen J, Weidenhaft MC, Shores N, Kimbrell HZ.

Mixed large cell neuroendocrine carcinoma and adenocarcinoma with spindle cell and

clear cell features in the extrahepatic bile duct. Case Rep Pathol. 2014;2014:347949.

PMID: 24804133

Qin Z, Dai L, Trillo-Tinoco J, Senkal C, Wang W, Reske T, Bonstaff K, Del Valle L, Rodri-

guez P, Flemington E, Voelkel-Johnson C, Smith CD, Ogretmen B, Parsons C. Targeting

sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary

effusion lymphoma. Mol Cancer Ther. 2014 Jan;13(1):154-64. PMID: 24140934

Mathur A, Abd Elmageed ZY, Liu X, Kostochka ML, Zhang H, Abdel-Mageed AB, Mondal

D. Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure aug-

ments docetaxel efficacy in castration resistant prostate cancer cells. PLoS One.

2014 Aug 14;9(8):e103109. PMID: 25121735

Saha D, Pal A, Biswas A, Panigrahi R, Sarkar N, Das D, Sarkar J, Guha SK, Saha B,

Chakrabarti S, Chakravarty R. Molecular characterization of HBV strains circulating

among the treatment-naive HIV/HBV co-infected patients of eastern India. PLoS One.

2014 Feb 28;9(2):e90432. PMID: 24587360

Strong AL, Shi Z, Strong MJ, Miller DF, Rusch DB, Buechlein AM, Flemington EK,

McLachlan JA, Nephew KP, Burow ME, Bunnell BA. Effects of the Endocrine-Disrupting

Chemical DDT on Self-Renewal and Differentiation of Human Mesenchymal Stem Cells.

Environ Health Perspect. 2015 Jan;123(1):42-8. PMID: 25014179

PATHWAYS Newsletter WINTER 2015 Page 16


Panigrahi R, Chandra PK, Ferraris P, Kurt R, Song K, Garry RF, Reiss K, Coe IR, Furihata

T, Balart LA, Wu T, Dash S. Persistent Hepatitis C Virus Infection Impairs Ribavirin Anti-

viral Activity through Clathrin-Mediated Trafficking of Equilibrative Nucleoside Trans-

porter 1. J Virol. 2015 Jan (1):626-42. PMID: 25339775

Park JH, Lee SB. An essential role for Ewing sarcoma gene (EWS) in early white adipo

genesis.Obesity (Silver Spring). 2015 Jan;23(1):138-44. PMID: 25407167

Strong MJ, Xu G, Morici L, Splinter Bon-Durant S, Baddoo M, Lin Z, Fewell C, Taylor CM,

Flemington EK. Microbial contamination in next generation sequencing: implications for

sequence-based analysis of clinical samples. PLoS Pathog. 2014 Nov 20;10

(11):e1004437. PMID: 25412476

Strong MJ, Lin Z, Flemington EK. Expanding the conversation on high-throughput vi-

rome sequencing standards to include consideration of microbial contamination sources.

MBio. 2014 Oct 28;5(6) PMID: 25352620

Zhuang Y, Nguyen HT, Burow ME, Zhuo Y, El-Dahr SS, Yao X, Cao S, Flemington EK,

Nephew KP, Fang F, Collins-Burow B, Rhodes LV, Yu Q, Jayawickramarajah J, Shan B.

Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of

MCF-7 breast cancer cells. Mol Carcinog. 2014 Oct 18. PMID: 25328122

Martin EC, Rhodes LV, Elliott S, Krebs AE, Nephew KP, Flemington EK, Collins-Burow

BM, Burow ME. microRNA regulation of mammalian target of rapamycin expression and

activity controls estrogen receptor function and RAD001 sensitivity. Mol Cancer. 2014

Oct 6;13:229. PMID: 25283550


Zhu H, Han C, Lu D, Wu T. miR-17-92 cluster promotes cholangiocarcinoma growth: evi-

dence for PTEN as downstream target and IL-6/Stat3 as upstream activator. Am J

Pathol. 2014 Oct;184(10):2828-39. PMID: 25239565 [

Sabahi A, Uprichard SL, Wimley WC, Dash S, Garry RF. Unexpected structural features

of the hepatitis C virus envelope protein 2 ectodomain. J Virol. 2014 Sep;88(18):10280-8.

PMID: 24991010

Kang HJ, Park JH, Chen W, Kang SI, Moroz K, Ladanyi M, Lee SB. EWS-WT1 oncoprotein

activates neuronal reprogramming factor ASCL1 and promotes neural differentiation.

Cancer Res. 2014 Aug 15;74(16):4526-35. PMID: 24934812

Qadir XV, Han C, Lu D, Zhang J, Wu T. Am J Pathol. miR-185 inhibits hepatocellular

carcinoma growth by targeting the DNMT1/PTEN/Akt pathway. 2014 Aug;184(8):2355-

64. PMID: 24911372

McCarthy M, Auda G, Agrawal S, Taylor A, Backstrom Z, Mondal D, Moroz K, Dash S. In

vivo anticancer synergy mechanism of doxorubicin and verapamil combination treatment

is impaired in BALB/c mice with metastatic breast cancer. Exp Mol Pathol. 2014 Aug;97

(1):6-15. PMID: 24780744

Castillo-Jorge S, Fauria-Robinson C, Palacios E, Nguyen J, Self R 2nd, Daroca P. Cal

varial plasmacytoma, an unusual manifestation of multiple myeloma. J La State Med

Soc. 2014 Jul-Aug;166(4):149-53. PMID: 25311457

Gunduz F, Mallikarjun C, Balart LA, Dash S.. Interferon alpha induced intrahepatic

pSTAT1 inversely correlate with serum HCV RNA levels in chronic HCV infection. Exp

Mol Pathol. 2014 Feb;96(1):36-41. PMID: 24211829



Bao L, Chandra PK, Moroz K, Zhang X, Thung SN, Wu T, Dash S. Impaired autophagy re

sponse in human hepatocellular carcinoma. Exp Mol Pathol. 2014 Apr;96(2):149-54.

PMID: 24369267

Lu D, Han C, Wu T. 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-

PGE2/PPAR-mediated activation of p21WAF1/Cip1. Oncogene. 2014 Feb 27;33(9):1101-

12. PMID: 23542179

O'Grady T, Cao S, Strong MJ, Concha M, Wang X, Splinter Bondurant S, Adams M, Bad-

doo M, Srivastav SK, Lin Z, Fewell C, Yin Q, Flemington EK. Global bidirectional tran-

scription of the Epstein-Barr virus genome during reactivation. J Virol. 2014 Feb;88

(3):1604-16. PMID: 24257595

Chandra PK, Bao L, Song K, Aboulnasr FM, Baker DP, Shores N, Wimley WC, Liu S,

Hagedorn CH, Fuchs SY, Wu T, Balart LA, Dash S. HCV infection selectively impairs type

I but not type III IFN signaling. Am J Pathol. 2014 Jan;184(1):214-29. PMID: 24215913

Kim KY, Hwang YJ, Jung MK, Choe J, Kim Y, Kim S, Lee CJ, Ahn H, Lee J, Kowall NW,

Kim YK, Kim JI, Lee SB, Ryu H. A multifunctional protein EWS regulates the expression

of Drosha and microRNAs. Cell Death Differ. 2014 Jan;21(1):136-45. PMID: 24185621

Zhang W, Edwards A, Flemington E, Zhang K. Somatic mutations favorable to patient

survival are predominant in ovarian carcinomas. PLoS One. 2014 Nov 12;9(11):e112561.

PMID: 25390899

Chandra PK, Gunduz F, Hazari S, Kurt R, Panigrahi R, Poat B, Bruce D, Cohen AJ, Be-

horquez HE, Carmody I, Loss G, Balart LA, Wu T, Dash S. Impaired expression of type I

and type II interferon receptors in HCV-associated chronic liver disease and liver cirrho-

sis. PLoS One. 2014 Sep 29;9(9) PMID: 25265476



Gandhi CR, Chaillet JR, Nalesnik MA, Kumar S, Dangi A, Demetris AJ, Ferrell R, Wu T,

Divanovic S, Stankeiwicz T, Shaffer B, Stolz DB, Harvey S, Wang J, Starzl TE. Liver-

Specific Deletion of Augmenter of Liver Regeneration Accelerates Development of Steato

hepatitis and Hepatocellular Carcinoma in Mice. Gastroenterology. 2014 Oct 13.

PMID:25448926.

Jeong S, Jing K, Kim N, Shin S, Kim S, Song KS, Heo JY, Park JH, Seo KS, Han J, Wu T,

Kweon GR, Park SK, Park JI, Lim K. Docosahexaenoic acid-induced apoptosis is medi

ated by activation of mitogen-activated protein kinases in human cancer cells. BMC

Cancer. 2014, 14(1):481. PMID:24993937.

Jing K, Shin S, Jeong S, Kim S, Song KS, Park JH, Heo JY, Seo KS, Park SK, Kweon GR,

Wu T, Park JI, Lim K. Docosahexaenoic acid induces the degradation of HPV E6/E7 on-

coproteins by activating ubiquitin-proteasome system. Cell Death D i s . 2 0 1 4 . N o v

13;5:e1524. PMID:25393480.

Yao L, Han C, Song K, Zhang J, Lim K, and Wu T. Omega-3 polyunsaturated fatty ac-ids upregulate 15-PGDH expression in cholangiocarcinoma cells by inhibiting miR-

26a/b expression. Cancer Res. In press.

Chen W, Han C, Zhang J, Song K, Wang Y, and Wu T. Deletion of mir-155 prevents

Fas-induced liver injury through upregulation of Mcl-1. Am J Pathol. In press.

Song K, Han C, Dash S., Balart LA, and Wu T. MiR-122 in hepatitis B virus and

hepatitis C virus dual infection. World J Hepatol. 2015, in press.

Xu G, Strong MJ, Lacey MR, Baribault C, Flemington EK, Taylor CM. RNA CoMPASS: a

dual approach for pathogen and host transcriptome analysis of RNA-seq datasets.

PLOS One. 2014 Feb 25;9(2) PMID: 24586784


PRESENTATIONS

Yao L, Han C, Song KS, Lim K and Wu T. -3 Polyunsaturated fatty acids regulate the

expression of 15-PGDH through miRNA26a and miRNA26b in cholangiocarcinoma

(Poster presentation). Hepatology 2014, 60(S1): 850A.The 65th Annual Meeting of the

American Association for the Study of Liver Diseases, Boston, MA. November 7 - 11,

2014

Song KS, Kwon HJ, Han C, Dash S and Wu T. Targeting CD133(+) cancer stem cells by

inhibiting glycolytic metabolism through miR-122 (AASLD Presidential Poster of Dis-

tinction). Hepatology 2014, 60(S1): 1185A-1186A.The 65th Annual Meeting of the

American Association for the Study of Liver Diseases, Boston, MA. November 7 - 11,

2014.

Yao l, Han C and Wu T. Microsomal prostaglandin E synthase-1 (mPGES-1) prevents

Fas-induced liver injury (AASLD Presidential Poster of Distinction). Hepatology

2014, 60(S1). 720 A. The 65th Annual Meeting of the American Associatin for the

Study of Liver Diseases, Boston MA. November 7-11, 2014.

Kwon HJ, Han C and Wu T. Role of Hedgehog signaling in hepatic steatosis (Poster

presentation). Tulane University Health Sciences Research Days, JBJ building Atrium.

New Orleans, LA. April 2-3, 2014.

Kwon HJ, Song KS, Han C and Wu T. Hedgehog pathway regulates hepatic inflamma-

tion in mice with nonalcoholic steatohepatitis (Poster presentation). Hepatology 2014,

60(S1): 759A.The 65th Annual Meeting of the American Association for the Study of

Liver Diseases, Boston, MA. November 7 - 11, 2014.

McNaughton J, Mayhall G, Schmid J: Red Blood Cell Transfusion and Red Blood Cell

Exchange in Sickle Cell Disease. Tulane Medical Center Sickle Cell Education Day,

September 2013.


PRESENTATIONS (CONTINUED)

Yao L, Han C and Wu T. -3 Polyunsaturated Fatty Acid Regulate the Expression of

15-PGDH through miRNA26a and miRNA26b in Cholangiocarcinoma (Oral

presentation). 2014 Tulane BMS (Graduate Program in Biomedical Sciences) Retreat,

Audubon Zoo. New Orleans, LA. October 17th, 2014.

Kwon HJ, Han C and Wu T. Hepatic Hedgehog signaling promotes macrophage-

mediate proinflammatory response through osteopontin regulation in mice with nonal-

coholic fatty liver diseases(NAFLD). (Poster presentation). 2014 Tulane BMS (Graduate

Program in Biomedical Sciences) Retreat, Audubon Zoo. New Orleans, LA. October

17th, 2014.

Ungerleider N, Han C and Wu T. TGFbeta sensitizes hepatocellular carcinoma cells to

growth factors, preventing sorafenib induced apoptosis. (Poster presentation). 2014

Tulane BMS (Graduate Program in Biomedical Sciences) Retreat, Audubon Zoo. New

Orleans, LA. October 17th, 2014.

Yao L, Han C and Wu T. DHA regulates the expression of 15-PGDH through miR26a/

b in cholangiocarcinoma (Oral presentation). FASEB J. 2014, 28: 144.12. Experimen-

tal Biology 2014, San Dieago, CA. April 26-30, 2014.

Ungerleider NA, Han C and Wu T. TGFbeta activates insulin-like growth factor1-

mediated signaling pathway in human liver cancer cells. (Oral presentation). FASEB J.

2014, 28: 144.9. Experimental Biology 2014, San Dieago, CA. April 26-30, 2014.

B. Xu, Y. Wang, B. Shan, D.E. Sullivan, and G.F. Morris. Regulation of MMP-9 in Lung

Tumor Cells by Interleukin-17. International Meeting of the American Thoracic Soci-

ety, San Diego, CA (2014).

PATHWAYS NEWSLETTER WINTER 2014


PRESENTATIONS (CONTINUED)

B. Xu, J.F. Guenther, Y. Wang, B. Chandrasekar, B. Shan, D.E. Sullivan, G.F. Morris.

IL-17 represses p53-dependent ribosomal stress in lung tumor cells. Tulane Univer -

sity Health Sciences Research Days (2014).

McNaughton J, Mayhall G, Schmid J: Red Blood Cell Transfusion and Red Blood Cell

Exchange in Sickle Cell Disease. American Federation for Medical Research, Southern

Regional Meeting 2014, February 20-22, 2014, New Orleans, LA

Panigrahi R: Persistently infected HCV cell culture impairs RBV antiviral activity

through clathrin mediated trafficking of ENT1. AASLD Meeting; November 7-11, 2014,

Boston, MA.

FACULTY INVITED PRESENTATIONS

Tong WU, M.D., PH.D.

Epigenetic Regulation of miRNA. AASLD Basic Research Single Topic Conference on

Non-coding RNAs in Liver Function and Dysfunction, Miami FL. March 7-8, 2014.

Erik Flemington, Ph.D.:

October 28th, 2014, "EBV lncRNAs in reactivation", University of North Carolina, Octo - ber 2014.

"Epstein Barr virus transcriptome discovery in reactivation and cancer, University of

Puerto Rico Medical Sciences, November 4, 2014,.


FACULTY INVITED PRESENTATIONS

(CONTINUED)

Sean Lee, Ph.D.

Department of Biochemistry and Molecular Biology, Tulane University School of

Medicine, New Orleans, LA (2014)

. Tulane Diabetes Research Program, Tulane University School of Medicine, New Or-

leans, LA (2014)

. Korean Society for Biochemistry and Molecular Biology Annual Meeting, Seoul, Ko-

rea (2014)

. Chungnam National University, School of Medicine, Daejeon, Korea (2014)

. The Catholic University of Korea, 60th Anniversary Symposium, Seoul, Korea (2014)

. Ilsong Institute of Life Science, Hallym University, Pyung Chon, Korea (2014)

. Tulane Hayward Genetics Center Grand Rounds, Tulane University, New Orleans,

LA (September 12, 2014)

Gil Morris, Ph.D.

Mechanisms of Matrix Metalloproteinase-9 Activation During Lung Tumor

Promotion by Interleukin-17. Lung Biology Group Meeting, April 28, 2014.

Cigarette Smoke Interaction with Inhaled Asbestos in a Murine Lung Disease

Model: Do E-cigarettes Have Similar Effects? Altria, Richmond, VA, July 14,

2014.

Molecular Aspects of Lung Cancer. Tulane University Pulmonary Fellows

Conference, October 8, 2014.

Cigarette Smoke Represses Activation of the NLRP3-Inflammasome by Inhaled As -

bestos. Lung Biology Group Meeting, October 22, 2014.



DR. SUZANNE MELEG-SMITH

IN MEMORIAM

Dr. Suzanne Meleg-Smith was born August 18, 1939 in Budapest, Hungary. Through the

course of her most dedicated and accomplished life, she would simultaneously hold three citi-

zenships: Hungarian, British and American.

Fluent in Spanish, Dr. Meleg-Smith graduated from the Javeriana Medical School at Bogota,

Colombia in 1957. For the next fourteen years, her time in Bogota was spent pursuing her

extraordinary medical career where she achieved several career milestones. She received her

M.D. in Medicine and Surgery in 1964, completed an internship at Samariana Hospital the

same year, and spent her residency St. San Jose Hospital from 19651968. From there she

went on to work as an Instructor of Pathology at the Javieriana School of Medicine and also

worked as an Oncological Pathology Fellow at Bogotas National Cancer Institute. She served

as an Associate Specialist of Pathology at the Military Hospital and University in Bogota.

When she later moved to North America, Dr. Meleg-Smith worked as a Visiting Scientist of

Nephropathology and Immunopathology at the University of New Mexico School of Medicine.

There she completed her residency in Anatomic Pathology and was named Chief Resident.

During her stint at the University of New Mexico School of Medicine, Dr. Smith, as an Assis-

tant Professor, was named the Director of Immunopathology and EM in the Department of

Pathology.

In 1992, she joined the Pathology Faculty at Tulane. Dr. Meleg-Smith was a dedicated and

committed member of the Department for twenty-two years. She was an excellent renal pa-

thologist and devoted teacher who always exhibited complete dedication to academic medi-

cine. Dr. Meleg-Smith mentored and taught many generations of students and residents who

later became excellent pathologists and nephrologists. She was a superb Professor of Pathol-

ogy, Head of Autopsy Service and Head of Renal Pathology. Her love and dedication to her

work was clear to all with whom she both worked and taught; her drive and energy were con-

tagious. Her colleagues have described her as someone who was a complete humanist with a

deep well of love and compassion for suffering.

Dr. Meleg-Smith is joined in death with her husband, Mr. Clive Smith. Their two children,

Anike and Paul, and four grandchildren survive them

Date post:	20-Nov-2015
Category:	Documents
Upload:	taliancich
View:	199 times
Download:	1 times

Pathways Winter 2015

Documents