BORS 2016 at University of Glasgow 2 nd call for abstracts. 5-6 th September 2016 Hosted by the Glasgow Orthopaedic Research Initiative (GLORI): Conference Chairs: Profs Matthew Dalby & Manuel Salmeron-Sachez and Mr Dominic Meek (Centre for Cell Engineering, University of Glasgow and Queen Elizabeth II University Hospital). GLORI organisers: Dr Monica Tsimbouri and Mr Peter Young FRCS (Centre for Cell Engineering, University of Glasgow) Local orgainising committee: Prof Ashraf Ayoub FRCS (Dental School) Dr Sylvie Coupard (Strathclyde Biomedical Engineering) Prof Helen Grant (Strathclyde Biomedical Engineering) Mr Fahd Mahmood (Golden Jubilee NHS Trust) Prof Stuart Reid (SUPA, Institute for Thin Films, Sensors and Imaging, UWS) Dr Phil Riches (Strathclyde Biomedical Engineering) Mr Neal Millar FRCS (Infection and Immunity) Prof Liz Tanner (Glasgow Bioengineering) Invited International Keynote – Prof Andrés J. García Ph.D., F.B.S.E. Rae S. and Frank H. Neely Chair and Regents’ Professor Woodruff School of Mechanical Engineering. Georgia Institute of Technology, USA. Engineered Hydrogels for Cell Delivery and Bone Repair Hydrogels, highly hydrated cross-linked polymer networks, have emerged as powerful synthetic analogs of extracellular matrices for basic cell studies as well as promising biomaterials for regenerative medicine applications. A critical advantage of these artificial matrices over natural networks is that bioactive functionalities, such as cell adhesive sequences and growth factors, can be incorporated in precise densities while the substrate mechanical properties are independently controlled. We have engineered poly(ethylene glycol) [PEG]-maleimide hydrogels for the controlled delivery of therapeutic proteins and human mesenchymal stem cells to heal critical-sized segmental bone defects in mice. Materials engineering to present integrin-specific, cell-adhesive peptides enhanced mesenchymal stem cell survival and engraftment and resulted in improved bone repair. Additionally, these materials can be engineered to reduce bacterial infections in the context of bone repair. These studies establish these engineered PEG hydrogels as promising biomaterial carriers for cell delivery, engraftment and enhanced tissue repair.
Hosted by the GlasgowOrthopaedic Research Initiative(GLORI):Conference Chairs: Profs Matthew Dalby & ManuelSalmeron-Sachez and Mr Dominic Meek (Centre for CellEngineering,UniversityofGlasgowandQueenElizabethIIUniversityHospital).GLORI organisers: Dr Monica Tsimbouri and Mr PeterYoung FRCS (Centre for Cell Engineering, University ofGlasgow)Localorgainisingcommittee:ProfAshrafAyoubFRCS(DentalSchool)DrSylvieCoupard(StrathclydeBiomedicalEngineering)ProfHelenGrant(StrathclydeBiomedicalEngineering)MrFahdMahmood(GoldenJubileeNHSTrust)Prof Stuart Reid (SUPA, Institute for Thin Films, SensorsandImaging,UWS)DrPhilRiches(StrathclydeBiomedicalEngineering)MrNealMillarFRCS(InfectionandImmunity)ProfLizTanner(GlasgowBioengineering)
Invited Clinical Keynote - Prof Jon Clasper CBEDPhil DM FRCSEd(Orth), Col L/RAMC -Emeritus Defence Professor & Consultant Orthopaedic Surgeon, Visiting Professor inBioengineering, Imperial College London, Clinical Lead, The Royal British Legion CentreforBlastInjuryStudies. 'BlastedBones'-Skeletalfailureafterexplosions!http://www.imperial.ac.uk/people/j.clasper
Invited Academic keynote - Prof Liam Grover - Professor in Biomaterials Science,DirectorofResearch,UniversityofBirmingham.ManipulatingossificationthroughchemistryAlthough inorganicmaterials such as hydroxyapatite and calcium sulphate are widelyusedforthereconstructionofhardtissuedefectsorforcoatingmetallicprosthetics,few
recognise the importance and therefore potential of a range of more complex inorganic materials tocontroltheprocessofossification.Thistalkwilldiscusshowmakingsubtlechangestothechainlengthofphosphate ions can generate materials that can bond bone, trigger extensive bone formation or evendemineralisehardtissue. Itwilldescribehowweareutilisingthiscomplexitytoaid intherepairofnon-unionandtheregenerationof largerbonedefects. Understandingthecomplexitiesofthemineralisationprocesshasalsoenabledustogenerate3Dinvitromodelsofbonethatcanmaintainosteocyteviabilityforin excess of one year. Thesemodels have been used as a platform to screen novel treatments for thedispersiononheterotopicossification.
BORSwillincludeaninvitedpubliclecturebyProfStuartReid,UWS.Stuartispartoftheinternationalteambehindthefirstdetectionofgravitationalwaves in2015,associatedwith twoblackholes colliding,andheraldedbymanyas the scientificbreakthroughofthe century. He has been centrally involved in developing interferometry-basedtechnology, which has been used alongside cell biologists to develop nanokicking, atechnologypioneeredinGlasgowforturningstemcellsintobone.“Gravitywaves,stemcellsandboneregeneration”
Sponsored Session: Precision Orthopaedics. Hosted by Mr Mark Blyth, ConsultantOrthopaedic Surgeon, Glasgow Royal Infirmary. This sessionwill focus on the drive forprecision and accuracy in orthopaedics, with presentations on implant design, throughmodernmanufacturingprocessestoprecisionsurgicaltechniques.ThefeaturetalkofthesessionwillbeareportontheTRUCKtrial-"TotalversusRoboticbi-UniCompartmentalKneearthroplasty".
BORS 2016will be held in the University of GlasgowUnion Building.Thevenue is in theUniversity’smainGilmorehill campus in theWestEndofthecity.TheWestEndofGlasgowisavery livelyenvironmentboastingmanygoodpubs,cafesandrestaurantsaswellasparkssuchasGlasgowBotanicalGardens.AbstractsshouldbesubmittedtoClaire.Osborne@glasgow.ac.ukby18thApril.TheywillappearinBJJProceedings.Titleshouldbeinboldcapitalflushtoleftmargin.Authorsnamesonnewlinestartingwithinitialandsurname(e.g.T.Smith).Nodegreesetc.Onefullcorrespondenceaddress.Leaveonespacebeforebeginningabstract,indenttextatbeginningofeachnewparagraphexceptthefirst.Nospaces.Wordlimit300.
Firstthemedsessionconfirmed:MolecularTendinopathy:towardstranslationChair:MrNealLMillarFRCS,PhD,UniversityofGlasgowInvitedSpeakers:DrStephanieGDiakin,UniversityofOxford-InflammationactivationandresolutionintendinopathyDrMandyPeffers,UniversityofLiverpool-ProteomicandtranscriptomicsignaturesintendondiseaseMrBenjaminJFDean,UniversityofOxford-NeuronalpathwaysintendinopathyThe session will also include 4 oral presentations on tendon research as judged from the abstractsubmissiontoBORS2016.SubmityourabstracttoClaire.osborne@glasgow.ac.ukby18thApril
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