BORS2016atUniversityofGlasgow2ndcallforabstracts.5-6thSeptember2016
Hosted by the GlasgowOrthopaedic Research Initiative(GLORI):Conference Chairs: Profs Matthew Dalby & ManuelSalmeron-Sachez and Mr Dominic Meek (Centre for CellEngineering,UniversityofGlasgowandQueenElizabethIIUniversityHospital).GLORI organisers: Dr Monica Tsimbouri and Mr PeterYoung FRCS (Centre for Cell Engineering, University ofGlasgow)Localorgainisingcommittee:ProfAshrafAyoubFRCS(DentalSchool)DrSylvieCoupard(StrathclydeBiomedicalEngineering)ProfHelenGrant(StrathclydeBiomedicalEngineering)MrFahdMahmood(GoldenJubileeNHSTrust)Prof Stuart Reid (SUPA, Institute for Thin Films, SensorsandImaging,UWS)DrPhilRiches(StrathclydeBiomedicalEngineering)MrNealMillarFRCS(InfectionandImmunity)ProfLizTanner(GlasgowBioengineering)
InvitedInternationalKeynote–ProfAndrésJ.GarcíaPh.D.,F.B.S.E.RaeS.andFrankH.NeelyChairandRegents’ProfessorWoodruffSchoolofMechanicalEngineering.GeorgiaInstituteofTechnology,USA.EngineeredHydrogelsforCellDeliveryandBoneRepairHydrogels,highlyhydratedcross-linkedpolymernetworks,haveemergedaspowerfulsyntheticanalogsofextracellularmatricesforbasiccellstudiesaswellaspromisingbiomaterialsforregenerativemedicineapplications.Acriticaladvantageoftheseartificialmatricesovernaturalnetworksisthatbioactivefunctionalities,suchascelladhesivesequencesandgrowthfactors,canbeincorporatedinprecisedensitieswhilethesubstratemechanicalpropertiesareindependentlycontrolled.Wehaveengineeredpoly(ethyleneglycol)[PEG]-maleimidehydrogelsforthecontrolleddeliveryoftherapeuticproteinsandhumanmesenchymalstemcellstohealcritical-sizedsegmentalbonedefectsinmice.Materialsengineeringtopresentintegrin-specific,cell-adhesivepeptidesenhancedmesenchymalstemcellsurvivalandengraftmentandresultedinimprovedbonerepair.Additionally,thesematerialscanbeengineeredtoreducebacterialinfectionsinthecontextofbonerepair.ThesestudiesestablishtheseengineeredPEGhydrogelsaspromisingbiomaterialcarriersforcelldelivery,engraftmentandenhancedtissuerepair.
Invited Clinical Keynote - Prof Jon Clasper CBEDPhil DM FRCSEd(Orth), Col L/RAMC -Emeritus Defence Professor & Consultant Orthopaedic Surgeon, Visiting Professor inBioengineering, Imperial College London, Clinical Lead, The Royal British Legion CentreforBlastInjuryStudies. 'BlastedBones'-Skeletalfailureafterexplosions!http://www.imperial.ac.uk/people/j.clasper
Invited Academic keynote - Prof Liam Grover - Professor in Biomaterials Science,DirectorofResearch,UniversityofBirmingham.ManipulatingossificationthroughchemistryAlthough inorganicmaterials such as hydroxyapatite and calcium sulphate are widelyusedforthereconstructionofhardtissuedefectsorforcoatingmetallicprosthetics,few
recognise the importance and therefore potential of a range of more complex inorganic materials tocontroltheprocessofossification.Thistalkwilldiscusshowmakingsubtlechangestothechainlengthofphosphate ions can generate materials that can bond bone, trigger extensive bone formation or evendemineralisehardtissue. Itwilldescribehowweareutilisingthiscomplexitytoaid intherepairofnon-unionandtheregenerationof largerbonedefects. Understandingthecomplexitiesofthemineralisationprocesshasalsoenabledustogenerate3Dinvitromodelsofbonethatcanmaintainosteocyteviabilityforin excess of one year. Thesemodels have been used as a platform to screen novel treatments for thedispersiononheterotopicossification.
BORSwillincludeaninvitedpubliclecturebyProfStuartReid,UWS.Stuartispartoftheinternationalteambehindthefirstdetectionofgravitationalwaves in2015,associatedwith twoblackholes colliding,andheraldedbymanyas the scientificbreakthroughofthe century. He has been centrally involved in developing interferometry-basedtechnology, which has been used alongside cell biologists to develop nanokicking, atechnologypioneeredinGlasgowforturningstemcellsintobone.“Gravitywaves,stemcellsandboneregeneration”
Sponsored Session: Precision Orthopaedics. Hosted by Mr Mark Blyth, ConsultantOrthopaedic Surgeon, Glasgow Royal Infirmary. This sessionwill focus on the drive forprecision and accuracy in orthopaedics, with presentations on implant design, throughmodernmanufacturingprocessestoprecisionsurgicaltechniques.ThefeaturetalkofthesessionwillbeareportontheTRUCKtrial-"TotalversusRoboticbi-UniCompartmentalKneearthroplasty".
BORS 2016will be held in the University of GlasgowUnion Building.Thevenue is in theUniversity’smainGilmorehill campus in theWestEndofthecity.TheWestEndofGlasgowisavery livelyenvironmentboastingmanygoodpubs,cafesandrestaurantsaswellasparkssuchasGlasgowBotanicalGardens.AbstractsshouldbesubmittedtoClaire.Osborne@glasgow.ac.ukby18thApril.TheywillappearinBJJProceedings.Titleshouldbeinboldcapitalflushtoleftmargin.Authorsnamesonnewlinestartingwithinitialandsurname(e.g.T.Smith).Nodegreesetc.Onefullcorrespondenceaddress.Leaveonespacebeforebeginningabstract,indenttextatbeginningofeachnewparagraphexceptthefirst.Nospaces.Wordlimit300.
Aswellasgeneralsessionsweareplanningthemedsessionssuchas:Advancedmanufacturing/precisionorthopaedicsMoleculartendinopathy–towardstranslation(seeover)StemcellsBiomechanicsSarcomaBlasttraumaBiomaterialsandtissueengineering
Registrationwillopenshortly.BORSstudent/traineemember£90Student/traineenonmember£120BORSmember£120Nonmember£150Plus£25fordinnerandceilidh
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Firstthemedsessionconfirmed:MolecularTendinopathy:towardstranslationChair:MrNealLMillarFRCS,PhD,UniversityofGlasgowInvitedSpeakers:DrStephanieGDiakin,UniversityofOxford-InflammationactivationandresolutionintendinopathyDrMandyPeffers,UniversityofLiverpool-ProteomicandtranscriptomicsignaturesintendondiseaseMrBenjaminJFDean,UniversityofOxford-NeuronalpathwaysintendinopathyThe session will also include 4 oral presentations on tendon research as judged from the abstractsubmissiontoBORS2016.SubmityourabstracttoClaire.osborne@glasgow.ac.ukby18thApril
