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Alcohol Digestion  Not digested like other foods  It can go directly into the

bloodstream

 Alcohol absorption throughoutthe GI tract

 It is quickly distributed

throughout the body

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 Alcohol Metabolism: Pathways

 Alcohol Dehydrogenase AD!"#tomach

$i%er 

Microsomal &thanol '(idi)ing #ystemM&'#"$i%er 

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* Ethanol oxidized→with ADH & ALDH→2mol NADH (2x2,5 mol ATP=5 mol ATP).

* Aetat→Aet!l"#oA→atal!ze $! Aet!l

#oA %!ntetha%e (need 2 mol ATP).* Aet!l"#oA → T#A !le = ' mol ATP

*  Total o mol ethanol oxidized= *

mol ATP

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Microsomal &thanol '(idi)ing

#ystem M&'#" Alternate pathway used+ in addition to

 AD!+ when alcohol intake is e(cessi%e

&nd products include:

&thanol acetaldehydeNADP! , !, NADP,

No A-P formation . &nergy /asteful

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* +ate i% exeted ia 2 o-te% 0 /* Secretion into the gut , and %-$%e0-en

de1adation $! $ateial -ia%e to #2and NH*.

 0 2/* Renal excretion 

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The urate transport systemsin the proximal tubule. 

-he kidney e(cretes 123 of the daily urate production4Urate anion transport function of URAT1 in renal proximal tubule epithelial

cells. The organic anion transporter URAT1 exchanges tubular lumen urate

with anions inside proximal tubular epithelial cells.

56A-78 5rate Anion -ransporter78" is targeted by uricosuric and

antiuricosuric agents4

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