Chapter VIII

REFERENCES

204

REFERENCES

1. Mathers CD, Stein C, Ma Fat D, Rao C, et al. Global burden of

diseases - 2000. Version 2, methods and results. GPE discussion paper

No:50. Geneva world Health Organization; 2002.

2. Salomon lA, Murray ClL. The epidemiological transition revisited:

compositional models for causes of deaths by age and sex. Population

and Development review 2002; 28(2) : 205-228.

3. WHO World Health Report 2002. Reducing risks promoting healthy

life. Geneva: WHO 2002.

4. Ramzi S Cortan, Vinay Kumar and Stanley L Robbins. The liver and

Biliary Tract. In: Robbins Pathologic Basis of Disease. 4th ed. WB

Saunders Company: Philadelphia;1989.p. 911.

5. Anthony PP, et al. The morphology of Cirrhosis: Definition,

nomenclature and classification. Bull WHO 1977; 55: 521.

6. Ramzi S Cortan, Vinay Kumar and Stanley L Robbins. The Liver and

Biliary Tract. In: Robbins Pathologic Basis of Disease. 4th ed. WE

Saunders Company: Philadelphia;1989. p. 916.

205

7. Zimmerman HJ. Intrahepatic cholestasis. Arch Intern Med 1979;

139: 1038.

8. Cohen GH, d' Arcy Doherty M. Free radical mediated cell toxicity by

redox cycling chemicals. Br J Cancer Suppl1987 Jun; 8: 46-52.

9. Poole A, Leslie GB. In: Practical Approach to Toxicological

Investigations. Cambridge University Press. 1989. p. 65-66.

10. Ed A Wallace Hayes. In: Principles and Methods of Toxicology, (2nd

ed). Raven Press: New York; 1989. p. 599-628.

11. Ed Timbell JA. In: Principles of Biochemical Toxicology. Jaylor and

Francis Ltd: London; 1982.p. 130, 131, 184-188.

12. Macdonald TL. Chemical mechanisms of halocarbon metabolism. Crit

Rev Toxicoll982; 11: 85-120.

13. Wieland T. The toxic peptides of Amanita phalloides. Fortschr Chern

Org Naturstoffe 1967;25:214-250.

14. Wieland T. Poisonous principles of Mushrooms of the Genus Amanita.

Science 1968; 159 (3818): 946-952.

15. Tyler VE Jr. Poisonous Mushrooms. Progr Chern Toxic 1963; 1:

339-384.

206

16. William Charles Evans. Hallucinogenic, Allergenic, Teratogenic and

other Toxic plants. In: Trease and Evans' Pharmacognosy. is" ed.

Bailliere Tindall London;1989.p. 755.

17. Varro E Tyler, Lynn R Brady and James E Robbers. Poisonous plants.

In: Pharmacognosy. 7th ed Lea and Febiger: Philadelphia; 1976.

p.472-488.

18. Ramzi S Cortan, Vinay Kumar and Stanley L Robbins. Environmental

Pathology. In. Robbins Pathologic Basis of Disease. 4th ed. WB

Saunders Company: Philadelphia; 1989.p. 500.

19. Ashburn LL, MeQueency AJ, Faulkner RR. "Scarring and

precirrhosis" of the liver in chronic phosphorus poisoning of Guinea

pig. Proc Sot Exp BioI Med 1948; 67: 351-358.

20. Matsumura F and Madhukar BV. Exposure to Insecticides. Pharmacol

Ther 1980; 9:27.

21. Cummings AJ, Kind ML, Martin BK. A kinetic study of drug

elimination: the excretion of paracetamol and its metabolites in man.

Br J Pharmacol 1967 Feb; 29(2): 150-7.

22. Hinson JA, Nelson.SD. Mitchell SR. Studies on the microsomal

formation of arylating metabolites of acetaminophen and phenacetin.

Mol Pharmacol1977 Jul; 13(4) :625-33.

207

D. Davis M. Labadarios D. Williams RS. Metabolism of paraeetamol after

therapeutic and hepatotoxic doses in man. J Int Moo Res 1916; 4­

(4 suppl): 40-5.

241. Olynyk JK. Clarke SL. Iron overload impairs pro-infIammamll)"

cytokine responses by kupffer cells. J Gastroenterol Heparol2001; 16:

438-44.

n. Mi1tlChell. JR. et al, Isoniazid liver m]llllII}'. Clinical spectrum, pallhologJ

and probable pathogenesis. AIm Intem Moo 1916; 841-181.

26. Chedid A" Mendenhall CL. Gartside P, French SW. Cbm T" Rabfum L.

Prognostic factors in alcoholic liver diseases, VA Co-operatioa :s;1tnDdy

groUDp. Am J Gastroemerol 1991 Feb; 86 (1): 1106.

n. GaJrdmter HW. Oxygen radical! clnemiimy ofpol~fatt11.y mm.

Free RUc;aill BioD Mall 1989; 1: 65.

11. Arndii RL" eral, PunrifiCOllllioo of oleic acid fiIIIIIId lliioollcic acid.. J lipiid Res

]983; 141-:485.

29. Dix'TA :mmll MilIUC1lllettlt U. CollD.wen;iiollD. of llDooJleiic acid~Dk t1l.Ol

Bnydroxyl, lkdo" qroxybydroxy md 1rihydmxy ffattly aci4k by~

J BioI Cbem ll985;260:: 5351.

208

30. Gebicki JM and Bialski BHJ. Comparison of the capacities of the

perhydroxyl and the superoxide radicals to initiate chain oxidation of

linoleic acid. J Am Chern Soc 1981; 103:7020.

31. Drill VA. Toxic liver injury. Am Inst BioI Sci publ. 1958; 4:441.

32. Robert A Roth. Inflammation and Hepatotoxicity. Is there a connection

to Drug Idiosyncracy? 3rd International conference on Idiosyncratic

Drug Toxicity. June 16thto l8th.2004: Downtown San Diego: CA.USA.

33. Debra L Laskin. Cytokines in Drug induced Liver injury - 3rd

International conference on IDT_16th to is" 2004 ;Downtown San

Diego: CA.USA.

34. Mohammed Bourdi. Role of Immune and Non-Immune Mediator in

Drug -induced Liver Idiosyncratic Toxicity- 3rd International

Conference on IDT - 2004 .

35. Amacher DE. A toxicologist's guide to bio-markers of hepatic

response. Human Exp Toxicol 2002 May; 21(5) : 253-62.

36. Pang JM, Zaleski J, Kauffman Fe. Actions of selected hepatotoxicants

on freshly isolated and cryopreserved rat hepatocytes. Cryobiology

1996 Apr: 33(2) 226-35.

37. Denk H. Drug Induced liver injury. Verh Dtsch Gis Pathol 2002; 86;

120-5.

209

38. Zimmerman HJ. Chemical laboratory manifestations of hepatotoxicity.

Ann NY Acad .Sci 1963; 104,954.

39. Himsworth HP. Lectures on the liver and its diseases. Harward

University Press; 1947, p.19.

40. Zimmerman HJ.The Spectrum of hepatotoxicity perspectives. Biol

Med 1968;2: 135.

41. Mohd Ali. Herbal Pharmacy. Indian J of Pharmaceutical Education

1997 Mar; 31: 13-17.

42. Handa SS, Sharma A, Chakarborti KK. Natural products and plants as

liver protecting drugs. Fitoterapia 1986; 57 (5): 307-351.

43. Salmi H, Sarna S. Effect of Silymarin on Chemical, functional and

morphological alterations of the liver. Scand J Gestroenterol 1982; 17:

517-521.

44. Ferenci, P, Dragosics B, Dittrich H, Frank H, Benda L, Lochs H,et al.

Randomized controlled trial of silymarin treatment in patients with

cirrhosis of the liver. Journal of Hepatology 1989;9:105-113.

45. . Muriel P, Mourelle M. Prevention by Silymarin of membrane

alterations in acute carbon-tetrachloride (CCI4) liver damage. J Appl

ToxicoI1990;10:275-279.

210

46. Buzzelli G, Moscarella S, Giusti A, Duchini A, Marena C, Lampertico

M. A pilot study on the liver protective effect of silybin phosphatidyl­

choline complex (IdB 1016) in chronic active hepatitis. International J

of Clinical Pathology, Therapy and Toxicology 1993; 31: 456-60.

47. Wang M, La Grange L, Tao 1. Hepatoprotective properties of silymarin

herbal preparation on ethanol-induced liver damage. Fitoterapia 1996;

67(2):166-171.

48. Kim NJ, Youn WG, Hong NO. Pharmacological effects of Lycium

chinensis. Korean J of Pharmacognosy 1994; 25 (3): 264-271.

49. Bishayee A, Sarkar A, Chatterjee M. Protective activity of carrot

(Daucus carota Linn.) against CCI4- intoxication in mouse liver. J

Ethnopharmaco1 1995; 47(2) : 69-74.

50. Gilani AU, Janbaz KH. Effects of Rubia cordifolia extract on

acetaminophen and CClcinduced hepatotoxicity. Phytotherapy

Research 1995; 9(5) : 372-375.

51. Singh A, Handa SS. Hepatoprotective activity ofApium graviolens and

Hygrophila auriculata against paracetamol and thioacetamide

intoxication in rats. J Ethnopharmacol1995; 49 (3): 119-126.

52. Aggarwal SS, Prakash J. Hepatoprotective activity / antihepatotoxic

studies on Zingiber officinale, Rosaceae. International seminar on

211

Recent Trends in pharm. sciences, Ootacamund. Abstr. No: D. 21, 18­

26th Feb. 1995.

53. Saraf S, Dixit VK, Patnaik OK, Tripathi SC. Antihepatotoxic activity

of Euphorbia antisyphilitica. Ind J of Pharm Sciences 1996; 88(4):

137-141.

54. Shirwaikar A, Sreenivasan KK, Krishnanand BR, Vasanth Kumar A.

Chemical investigation and antihepatotoxic activity of the root bark of

Capparis spinosa. Fitoterapia 1996; 67(3): 200-204.

55. Liu OT. Pharmacological actions and clinical uses of Fructus

Schizandrae. Chin Med J 1989; 102:740-749.

56. Li XY. Bioactivity of neolignans from Fructus Schizandrae. Mem Ins

Oswaldo Cruz 1991; 86: 31-37.

57. Ko KM, Yick PK, Poon MKT, Che CT, Ng KH and Kong vc

Schizandra chinensis - derived antioxidant activities in 'Sheng Mai

San', a compound formulation in vivo and in vitro. Phytotherapy Res

1995; 9: 203-206.

58. Ko KM, Ip Sp, Poon MKT, We SS, Che CT, Ng KH, Kong vc.

Effect of lignan enriched Fructus Schizandrae extract on hepatic

glutathione status in rats: protection against CC14 toxicity. Planta Med

1995 April;61:134-137.

212

59. Ka-Ming KO, Michel KT Poon, Siu-Polp and Kim WU. Protection

against CCl4 liver toxicity by enantiomers of schizandrin B associated

with differential changes in Hepatic glutathione antioxidant system in

mice. Pharmaceutical Biology 2002; 40(4): 298-30.

60. Saenz Rodriguez T, Garcia Gimenez D, De la Puerta Vazquez R.

Choleretic activity and biliary elimination of lipids and bile acids

induced by an artichoke leaf extract in rats. Phytomedicine 2002 Dec;

9(8): 687-93.

61. Speroni E, Cervellati R., Govoni P, Guizzardi S. Renzulli e. Guerra

Me. Efficacy of different Cynara scolymus preparations on liver

complaints. J Ethnopharmacol 2003 ; 86 (2-3): 203-11.

62. Jimenez-Eserig A., Dragsted LO, Daneshvar B., Pulidom R, Saura­

Calixto F. In vitro antioxidant activities of edible artichoke (Cynara

scolymus L.) and effect on biomarkers of antioxidants in rats. J Agri

Food Chern 2003 Aug. 27; 51(18): 5540-5.

63. Autor AP. In: Lipid Peroxides in Biology and Medicine. Yagi K (ed)

Academic Press: INC; Orlando, Floride; 1982.

64. Halliwell Band Gutteridge JMe. In: Free Radicals in Biology and

Medicine. Clarendon Press :Oxford; 1985.

213

65. JA Imlay and I. Fridovich. Suppression of oxidative envelope damage

by pseudo reversion of a superoxide dismutase deficient mutant of

Escherichia coli. J Bacteriol1992 Feb; 174(3): 953-961.

66. Dionsi 0, Galeotti T, Terranova T, Azzi A. Superoxide radicals and

hydrogen peroxide formation in mitochondria from normal and

neoplastic tissues. Biochem Biophys Acta 1975; 403(2):292-300..

67. Sies H. In:"Oxidative stress, oxidants and Antioxidants". Sies H. (ed)

San Diego: CA; Academic press; 1991.p.15.

68. Miquel J, Quintanilha AT and Weber H. In:"CRC Handbook of free

radicals and Antioxidants in Biomedicine." Vol II. Boca Raton. FL:

CRC Press;1989.

69. Timothy J and Laurie C. In:"Phytochemistry of medicinal plants". John

TA, Rachel M and John TR (eds). 1995; 29: 161.

70. Barry Halliwell and John MC Gutteridge. Lipid peroxidation: a radical

chain reaction. In: Free radicals in Biology and Medicine. Clarendon

press :Oxford. 1989; p.188-236.

71. Mason RP. In:"Free radicals in Biology". Pryor WA (ed) Academic

press: New York; 1982.p. 161.

72. Slater TF. In: Free radical mechanism in tissue injury. Pion press Ltd.

London; 1972.

214

73. Barry Halliwell and John MC Gutteridge. Protection by enzymes. In:

Free radical in Biology and Medicine. Clarendon Press: Oxford;

1989.p.l09.

74. Meister A. In: Glutathione, Chemical, Biochemical and medical

aspects. Dolphin D, Paulson Rand Arramovic O. (eds). Vo1.3. Part A.

New York :John Wiley and Sons;1989;p. 367.

75. DR Lawrence, PN Bennett. Clinical pharmacology. ihed. Churchill

Livingstone: Medical Division of Longman group; UK, Ltd; 1992.p.

270-71.

76. Rao KS, Mishra SH. Hepatoprotective activity of the whole plant of

Fumaria indica. Indian J Pharmaceutical sciences 1979; 59(4) :

165-70.

77. Slater TF, KH Cheeseman and KU Ingold. Carbon tetrachloride

toxicity as a model for studying free-radical mediated liver injury.

Philosophical transactions of the Royal society of London-series. B

BioI Sci 1985; 311 (1152): 633-645.

78. Premkumar K, A Pachiappan, SK Abraham, ST Santhiya, PM

Gopinath and A Ramesh. Effect of Spirulina fusiformis on cyclo­

phosphamide and mitomycin C- induced genotoxicity and oxidative

stress in mice. Fitoterapia 2001; 72: 906-911.

215

79. Visen PKS, Shukla B, Patnaik GK, Chandra R., Singh V, Kapoor NK.

Hepatoprotective activity of picroliv isolated from Picrorrhiza kurroa

against thioacetamide toxicity on rat hepatocyte. Phytotherapy Res

1991; 5: 224-7.

80. Zimmerman HJ. In: Hepatotoxicity. Appleton century crafts, 1978;

p.167-259.

81. Grice HC, Berth ML, Coraish HH, Foster GV, Gray RH. Correlation

between serum enzymes patterns and histologically detectable organ

damage. Food Cosmet Toxicol1971; 9:847-52.

82. Priest RE, Smuckler EA, Iseri OA and Beneditt, EP. Liver Lipid

peroxide levels in Carbon tetrachloride poisoning. Proc Soc Exptl Biol

Med 1962; 111:50.

83. Recknagel RO and Ghoshal AK. Accumulation of lipoperoxidation by

Carbon-tetrachloride. Fedn Proc Fedn Amer Socs Expl Biol 1965;

24:249.

84. Recknagel RO and Ghoshal AK. Newdata on the question of

lipoperoxidation in carbontetrachloride poisoning. Expt Mol Pathol

1966;5:108.

85. Placer Z, Veselkova A and Rath R. Kinetic des Malandialdehyde in

organisms. Experientia 1965;21:19.

216

86. Butler TC. Reduction of CCl4 in vivo and reduction of CCl4 and

chloroform in vitro by tissues and tissue constituents. J Pharmacol

Exptl Therap 1961; 134:311.

87. Lieber CS, Teschke R, Hasumura. Y, Decarli LM. Differences in

hepatic and metabolic changes after acute and chronic alcohol

consumption. Fed Proc 1975; 34:2060-74.

88. Dhawan D, Goel A, Karkara K. Effect of CCl4 and Liv 52 on the

clearance rate of 1331-Rose Bengal in rat liver. AMPI Med Phys Bull

1991; 16: 27-29.

89. Indira Balachandran and VV Sivarajan. Ayurvedic Drugs and their

plant sources. (Isted). Oxford and IBH publishing Company Pvt. Ltd:

New Delhi; 1994.

90. Sane RT, Kuber VV, Challisary MS, Menon S. Hepatoprotection by

Phyllanthus amarus and Phyllanthus deblis in CC4-induced liver

dysfunctions.Current science 1995; 68: 1243- 1246.

91. Recknagel RO, Glende EA,. Hruszkewyez AM. In: Free radicals in

Biology. Vol.III.( Ed.) Prayer EA. Academic press: New york. 1976;

97-132.

92. Rees KR, Sinha KP and Spector WG. Effect of liver poisons on liver

cells. J Pathol Bacteriol 1961; 81: 108.

217

93. .Smuckler EA, Iseri OA and Beneditt P. An intracellular defect in

protein synthesis induced by Carbon tetrachloride. J Exptl Med 1962;

116: 55.

94. Comporti M, Saccocin C and Dianzani MW. Effect of CCl4 in vitro

and in vivo on lipid peroxidation of rat liver. Homogenate and sub­

cellular fraction. Enzymalgia 1965; 7:27.

95. Dianzani MD, Baccino FM and Comporti M. The direct effect of CCl4

on subcellular particles. Lab invest 1966; 15:149.

96. Glende EA Jr and Recknagel RO. Biochemical basis for the invitro

pro-oxidant action of CCI4. Expt Mol Pathol 1969; 11:172.

97. Vellarruel MC and Castro JA. Irreversible binding of CCl4 to

microsomal phospholipids:free radical nature of the reactive species

and alteration in the physicochemical properties of the target fatty

acids. Res Commu Chern Pathol Pharmacol1975; 101:105.

98. Harper HA. The functions and tests of the liver. In: Review of

Physiological chemistry. Los Altos: California: Lange Medical

Publisher ;1961.p.271-83.

99. Drotman RB, Lawhorn GT. Serum enzymes as indicators of

chemical-induced liver damage. Drug chern ToxicoI1978;1:163-71.

218

100. Annie Shirwaikar, KK Sreenivasan. Chemical investigation and

antihepatotoxic activity of the fruits of Lagenaria siceraria. Ind J

Pharm Science 1996;58(5):197-202.

101. BH Babu, BS Shylesh, J Padikkala. Antioxidant and hepato protective

effects of Acanthus elicifolius. Fitoterapia 2001; 72:272-277.

102. Bahar Ahmed, Tanveer Alam, Manoj Varshney, Shah Alam Khan.

Hepatoprotective activity of two plants belonging to the Apiaceae and

Euphorbiaceae family. J Ethnopharmacol 2002; 79:313-16.

103. MS Dhumal, IH Mane, SS Patel. Effect of Liv 52 on carbon

tetrachloride. Ind J Pharmacol 1989; 21:96-99.

104. Soni MG, Mahendale HM. Hepatic failure leads to lethality of

chlordecone - amplified hepatotoxicity of carbon tetrachloride.

Fundam Appl Toxicol 1993 Nov; 21(4):442-50.

105. Agostini C, Alfisi Moo Changes in serum proteins and in major liver

constituents following carbon tetrachloride and a high fat choline-free

diet in rats. Experientia 1979 Sep; 35(9):1225-6.

106. Ohta Y, Sasaki E, Nishida K, Kobayashi T, Nagata M, Ishiguro 1.

Preventive effect of dai-Saiko-to (da-chai-hu-tang) extract on

disrupted hepatic active oxygen metabolism in rats with CCl4 ­

induced liver injury. Am J Chin Med 1995;23(1):53-64.

219

107. K Ashok Shenoy, SN Somayaji, KL Bairy. Hepatoprotective effects

of Ginkgo biloba against carbon tetrachloride - induced hepatic injury

in rats. Ind J Pharmacol 2001;33:260-67.

108. Dhawan D, Goel A."Further evidence for zinc as a hepatoprotective

agent in rat liver toxicity. Exp Mol Pathol 1995 Oct; 63(2):110-7.

109. Wang DH, Ishii K, Zhen LX, Taketa K. Enhanced liver injury in

acatalasemic mice following exposure to carbon tetrachloride. Arch

Toxicol 1996;70(3-4): 189-94.

110. Rao KS, Recknagel RO. Early onset of lipoperoxidation in rat liver

after carbon tetrachloride administration. Exp Mol Pathol 1968 Oct;

9(2):271-8.

111. Campo GM, Squadrito F, Ceccarelli S,Calo M, Avenoso A,Campo

S,et al. Reduction of Carbon tetrachloride-induced rat liver injury by

IRFI 042, a novel dual vitamin-E like anti oxidant. Free Radic Res

2001 Apr; 34 (4): 379- 93.

112. Camps J, Bargallo T, Gimenez A, Alie S, Cavalleria J, Pares A, et

al. Relationship between hepatic lipid peroxidation and fibrogenesis

in carbontetra chloride-treated rats: effect of zinc administration.

Clinical Science 1992; 83: 695-700

220

113. Kiso Y, Tohkin M, Hikino H, et al. Mechanism of anti hepatotoxic

activity of Glycyrrhizin. Effect on free radical generation and lipid

peroxidation. Planta Medica 1984; 50: 298-302.

114. Vermeulen NPE, Bessems JGM, Vandestraat R. Molecular aspects of

paracetamol-induced hepatotoxicity and its mechanism-based

prevention. Drug metabolism Rev 1992; 3:367-407.

115. Liu J, Uu Y, Mao Q, Klaassen CD. The effects of triterpenoid

compounds on experimental liver injury in mice. Fundamental Appl

Toxicol 1994;22:34-40.

116. Walker Robin M, Reez WJ, MC Elligot TF. Scanning electron

microscopic examination of acetaminophen-induced hepatotoxicity

and congestion in mice. Am J Pathol 1983; 13:321-30.

117. Hong RW, Rounds JD, Helton WS, Robinson MK, Wilmore DW.

Glutamine preserves liver glutathione after lethal hepatic injury. Ann

Surg 1992; 215:114-19.

118. Miki ELY, Ichi FY, Simizu H, Karia K. Selective release of

glutathione transferase subunits from primary cultured rat hepatocytes

by carbon tetrachloride and deoxycholic acid.Toxicology 1991; 67:

37-48.

221

119. Dixon MF, Nimmo J, Prescott LF. Experimental paracetamol

induced hepatic necrosis-a histopathological study. J Pathol

1971;103:225-27.

120. Weishen B, Kamendulis LM, Sidharthan DR, Corcoran GB.

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes:

Effects of Ca2++ endonuclease DNA repair and glutathione depletion

inhibitors on DNA fragmentation and cell death. Toxicol Appl

Pharmacol 1992; 112:32-4.

121. Ryu BK, Ahn BO, Oh TY, Kim SH, Kim WB, Lee EB. Studies on

protective effect of DA-960 1, Artemisia asiatica extract, on

acetaminophen and CC14 -induced liver damage in rats. Arch Pharm

Res 1998 Oct; 21( 5):508-11.

122. Padma GM Rao, Gurumadhava Rao, Ramanarayan K and Sreenivasan

KK. Effect of hepatogard on paracetamol-induced liver injury in

male albino rats. Indian Drugs 1993;30(1):40-4.

123. James OWL, Pickering RW. The protective effect of a novel

compound Ru-18492 on galactosamine-induced hepatotoxicity in rat.

Arzneimittel Forschung (Drug Research) 1976; 26:2197-9.

222

124. Dwivedi Y, Rastogi R, Garg NK, et al. Picroliv and its components,

Kutkoside and Picroside I, protect liver injury against galactosamine­

induced damage in rats. Pharmacol ToxicoI1992;71:383-87.

125. Visen PK, Shukla B, Patnaik OK, et al. Prevention of galactosamine­

induced hepatic damage by picroliv: Study on bile flow and isolated

hepatocytes in vivo. Planta Medica 1993; 59:37-41.

125. M Sreeramamurthy, M Srinivasan. Hepatoprotective effect of

Tephrosia purpurea in experimental animals. Ind J Pharmacol

1993;25:34-36.

126. Aftab Ahmed, KK Pillai, Shibli Jameel Ahmed, DK Balani, AK

Najmi, Renuka Marwah, Abdul Hameed. Evaluation of the

hepatoprotective potential of Jigrine pretreatment on thioacetamide­

induced liver damage in rats. Ind J Pharmacol 1999;31:416-21.

127. Venkatesha Udupa, Kala Suhas Kulkarni, Md Rafiq, S

Gopumadhavan, MV Venkataranganna, SK Mitra. Effect of HD -03,

on levels of various enzymes in paracetamol - induced liver damage in

rats.Ind J Pharmacol 2000;32:361-64.

128. MR Venukumar, MS Latha. Hepatoprotective effect of the methanolic

extract of Curculgo orchioides in CCl4-treated male rats. Ind J

PharmacoI2002;34:269-75.

223

129. Doreswamy R, Sharma D.Plant drugs for liver disorder management.

Indian Drugs 1995;32: 139-144.

130. Handa SS, Sharma A, Chakraborty KK. Natural Products and plants

as liver protecting drugs. Fitoterapia 1989;57:307-51.

131. Vaidya AB, Sirsat SM, Doshi JC, Antarkar DS. Selected medicinal

plants and formulations as Hepato-biliary drugs- An overview. Ind J

Clin Pharmacol Ther 1996; 7-11.

132. Bhatt AD and Bhatt NS. Indigenous drugs and liver disease. Ind J

Gastroenterol 1996;15:65-67.

133. Hikino H, Kiso Y. Natural products for liver diseases. In: Economic

and Medical medicinal plant research. vol 2. Academic press: London;

1988;p. 39-72 .

134. Evans we. An overview of drugs having antihepatotoxic and oral

hypoglycemic activities. In: Trease and Evans' Pharmacognosy. 14th

ed. UK: WD Saunders Company Ltd; 1996.

135. Sharma A, Shing RT, Sehal V, Handa SS. Antihepatotoxic activities

of some plants used in herbal formulations. Fitoterapia 1991;

62:131-8.

136. A Subramoniam, P Pushpangadan. Development of phytomedicines

for liver diseases. Ind J Pharmacol 1999;31:166-75.

224

137. Chakaraborti KK, Handa SS. Antihepatotoxic activity of Boerhavia

diffusa and B. repanda. Indian Drugs 1989: 19-24.

138. Sharma AK, Anand KK, Pushpangadan P, Chandan BK, Chopra CL,

et al. Hepatoprotective effects of Wedelia calendulacea. J

Ethnopharmacol1989; 25: 93-102.

139. Handa SS, Anupam Sharma. Hepatoprotective activity of

Andrographolide from Andrographis paniculata against carbon tetra

chloride. Ind J Med Res 1990; 92 (B): 276-93.

140. Akintonwa A, Essien AR. Protective effect of Garcinia kola seed

extract against paracetamol-induced hepatotoxicity in rats. J

Ethnopharmol 1990 May; 29 (2): 207-11.

141. Sudhir S, Budhiraja RD. Protective effect of Withaferin aganist an

experimental model of hepatitis. Ind J Pharmacol 1991;23:16-20.

142. Saraf S, Dixit VK. Hepetoprotective activity of Tridax procumbens­

Part II. Fitoterapia 1991; 62: 534-36.

143. Chattopadhyay RR, Sarkar SK, Ganguly S, Medda C, Basu TK.

Hepatoprotective activity of Ocimum sanctum leaf extract against

paracetamol-induced hepatic damage in rats. Ind J Pharmaco1 1992;

24: 163-65.

225

144. Rana AC, Avadhoot A. Experimental evaluation of hepatoprotective

activity of Gymnema sylvester and Curcuma zedoeria. Fitoterapia

1992;63: 60-2.

145. Saxena AK, Singh B, Anand KK. Hepatoprotective effects of

Eclipta alba on subcelluar levels in rats. J Ethnophannacol

1993;40:155-61.

146. Mandal PK, Bishayee A, Chatterjee M. Stimulation of tissue repair by

Mikania cordata extract on CCl4.induced liver injury in mice.

Phytotherapy Res 1993:7: 103-5.

147. Reddy BP, Murthy VN, Venkateshwarlu V, Kokate CK, Rambhau

D. Antihepatotoxic activity of Phyllanthus niruri, Tinospora

cordifolia and Ricinus communis. Indian Drugs 1993;30:338-41.

148. Gulati PK, Agarwal S, Agarwal SS. Hepatoprotective studies on

Phyllanthus emblica Linn. and Quercetin. Ind J Exp BioI 1994; 33:

261-8.

149. Gadgoli C, Mishra SH. Preliminary screening of Achillea

millefolium, Cichorium intybus and Capparis spinosa for

antihepatotoxic activity. Fitoterapia 1995; 66: 319-23.

226

150. KH Janbaz, AH Gilani. Evaluation of the protective potential of

Artemisia maritima extract on acetaminophen and CC14jnduced liver

damage. J Ethnopharmacol 1995; 47 (1): 43-47.

151. Subramoniam A, Rajasekharan S, Vinodkumar TO, Puspangadan P.

Studies on the hepatoprotective activity of Geophila reniformis.

Proceedings of the 6th World Congress on Holistic life and

Medicine; 1996 Jan 5-7; Kozhikode, India, (Abstract)

152. Jayasekhar P, Mohanan PV, Rathinam K. Hepatoprotective activity

of ethyl acetate extract of Acacia catechu. J Pharmacol 1997; 29:

426-8.

153. Mitra S, Sur RK. Hepatoprotection with Glycosmis pentaphylla.

Ind J Exp BioI 1997; 35: 1306 -9.

154. Mukherjie S, Sur A, Maiti BR. Hepatoprotective effect of Swertia

chirata on rats. Ind J Expt Biol 1997;35: 384-8.

155. Kumar S Rao, SH Mishra. Anti inflammatory and hepatoprotective

activities of Sida rhombifolia Linn. Ind J Pharmacol 1997; 20:

110-16.

156. Singh B, Saxena AK, Chandran BK, Anand KK, Suri OP, et al.

Hepatoprotective activity of Verbenalin on experimental liver damage

in rodents. Fitoterapia 1998; 69: 135-41.

227

157. Santra A, Das S, Maity A, et al. Prevention of Carbon tetra

chloride-induced hepatic injury in mice by Picrorrhiza kurroa. Ind J

Gastroenterology 1998, 17:6-9.

158. Bindhuja Saraswath, PKS Visen, GK Padnaik, BN Dhwan. Ex vivo

and in vivo investigations of picrolive from Picrorrahiza kurroa in an

alcohol intoxication model in rats. J Ethnopharmacol 1999; 66 (3):

263-269.

159. Ruckmani K, Kavimani S, Anandan R, Jayakar B. Effect of

Moringa oleifera Lam. on Paracetamol-induced hepatotoxicity. Ind J

Pharm Sci 1998;60:33-5.

160. Rege NN, Javle H, Bapat RD, et al. Antiendotoxic effect of

Tinospora cordifolia; an experimental study in rats. Ind J Surg

1998; 60-303-5.

161. Deshpande DR, Gadre SO, Raste AS, et al. Protective effect of

Turmeric (Curcuma Zonga) extract on Carbon tetrachloride-induced

liver damage in rats. Ind J Exp Biol 1998;36(6):573-77.

162. Subramoniam A, Evans DA, Rajasekharan S, Pushpangdan P.

Hepatoprotetive activity of Tricopus zeylanicus extract against

paracetamol induced hepatic damage in rats. Ind J Expt Biol 1998;

36:385-9.

228

163. Fahim FA, Esmat AY, Fadel HM, Hassan KF. Allied studies on the

effect of Rosmarinus officinalis L. on experimental hepatotoxicity and

mutagenesis. Int J Food Sci Nutr 1999 Nov; 50(6):413-27.

164. Padma P, et al. Protective effect of Phyllanthus fraternus against

carbon tetrachloride- induced mitochondrial dysfunction. Life science

1999; 64(25):2411-17.

165. Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY.

Hepatoprotective effects of Arctium lappa (Linn) on carbon

tetrachloride and acetaminophen-induced liver damage. Am J Chin

Med 2000; 28(2):163-73.

166. Ahmed MB, Khater MR. Evaluation of the protective potential of

Ambrosia maritima extract on acetaminophen-induced liver damage. J

Ethnopharmacol 2001; 75: 169-74.

167. Prasanna Habbu, Hukkeri VI, Hunasegi BS. Screening of Hedychium

spicatum for hepatoprotective activity in albino rats. Indian Drugs

2002;39(2): 117-119.

168. Annie Shirwairkar, R Padma, A. Vasanth Kumar and Lakshmi Rao.

Hepatoprotective activity of Polygala elongata against CCl4-induced

hepatotoxicity in rats. Ind J Pharm Sci 2002;345-348.

229

169. Rajkapoor B, Anandan R and Jayakar B. Hepatoprotective activity of

Nigella sativa Linn. Indian Drugs 2002;39(7):398-399.

170. AI- Ghamdi MS. Protective effect of Nigella sativa against CCI4­

induced liver damage. Am J Chin Med 2003;31(5):721-28.

171. Ozbek H, Ugras S, Dulger H, Bayram I Tuncer I, Ozturk G, et al.

Hepatoprotective effect of Foeniculum vulgare essential oil.

Fitoterapia 2003 Apr: 74(3):317-19.

172. Bhanwra S. Singh J., Khosla P.: Effect of Azadiracta indica (Neem)

leaf aqueous extract on paracetamol - induced liver damage in rats.

Ind. J. Physiol. Pharmaco12000 Jan;44(1):64-8.

173. Yanpallewar SU, Sen S. Tapas S. Kumar M, Raju SS, Acharya SB.

Effect of Azadiracta indica on paracetamol - induced hepatic damage

in albino rats. Phytomedicine 2003;10(5):391-6.

174. Chauhan BL, Mohan AR, Kulkarni RD, Mitra SK. Bioassay for

evaluation of the hepatoprotective effect of Liv-52, a polyherbal

formulation, or ethanol metabolism in chronic alcohol exposed rats.

Ind J Pharmacol 1994:26: 117-20.

175. Kataria M, Singh LN. Hepatoprotective effect of Liv. 52 and

Kumaryasava on carbon tetrachloride induced hepatic damage in rats.

Ind J Expt BioI 1997; 35:655-7.

230

176. Suja V, Sharmila SL, Shyamala Devi C. Protective effect of Liv 52 and

Liv.lOO, Ayurvedic formulations on lipid peroxidation in rat liver

homogenate - an in vitro study. Ind Exp Bio11997;35:50-2.

177. Saraswathy SD, Suja V, Ourumurthy P, Shyamala Devi CS. Effect of

Liv-100 against antitubercular drugs isoniazid, rifampicin and

pyrazinamide) induced hepatotoxicity in rats. Ind J Pharmacol 1998;

30:233-38.

178. Kapur V, Pillai K.K, Hussain SZ, Balani DK. Hepatoprotective activity

of Jigrine on liver damage caused by alcohol- carbon tetrachloride and

paracetamol in rats. Ind J Pharmacol 1994; 26: 35-40.

179. Karunakar N, Pillai KK, Hussain SZ, et al. Further studies on the

antihepatotoxic activity of Jigrine. Ind J Pharmaco11997; 29: 222-27.

180. Sharma M, Tripathi P, Singh VP, Tripathi YS. Hepatoprotective and

toxicological evaluation of hepatomed, an ayurvedic drug. Ind J Exp

Bio11995; 33: 34-7.

181. Farooq S, Ahmed I, Pathak OK. In vivo protective role of Koflet (an

ayurvedic preparation) against cellular toxicity caused by CC14 and fly

ash. J Pharmaco11997; 58: 149-56.

231

182. Asha. V.V. Pushpangadan P. Preliminary evaluation of antihepatotoxic

activity of Phyllanthus madaraspatensis, P. kozhikodianus and

Solanum indicum.Fitoterapia 1998;6:16-18.

185. Kumar SR., Mishra SH. Isolation and assessment of hepatoprotective

activity of ursolic acid obtained for the first time from Sida cordifolia

Linn. Indian Drugs, 1997; 34: 702-6.

186. Shukla B, Visen PKS, Patnaik OK, Tripathi se, Srimal Re, et al.

Hepatoprotective activity of ursolic acid isolated from Eucalyptus

hybrid in the rat. Phytotherapy ResO 1992; 6: 74-9.

187. Saraswath B, Visan PKS, Dayal R, Agarwal DP, Patnaik OK.

Protective action of urolic acid against chemical induced

hepatotoxicity in rats. Ind J Pharmacol1996; 28: 232-9.

188. Lau KM, He ZD, Dong H, Fung KP, But PP. Antioxidative, anti­

inflammatory and hepatoprotective effects of Ligustrum robustum J

Ethnopharmacol2002 Nov; 93(1-2): 63-71.

189. Ye YN, Liu ES, Li Y, So HL, Cho cc, Sheng HP, et al. Protective

effect of polysaccharides -enriched fraction from Angelica sinensis on

hepatic injury. Life Science 2001 Jun: 69(6): 637-46.

190. Lin CC, Huang Pc. Antioxidant and hepatoprotective effects of

Acathopanax senticosus .Phytother Res 2000; 14(7): 489-94.

232

191. Sultana S, Perwaiz S, Iqbal H, Althar M. Crude extracts of

hepatoprotective plants, Solanum nigrum and Cichorium intybus that

inhibit free radical mediated DNA damage . J Ethnopharmacol 1995

Mar; 45 (3): 189-92.

192. Aktay G, Deliorman D, Ergun E, Ergun F, Yesilada E. Cevik C.

Hepatoprotective effects of Turkish folk remedies on experimental

liver injury. Pharmacol2000; 73(1-2) 121-9.

193. Trivedi WP, Rawal UM. Hepatoprotective and antitoxidant property of

Andrographis paniculata (Nees) in BHC- induced liver damage in

mice. Ind J Exp BioI 2001 Jan; 39(1): 41-6.

194. Lin CC, Hsu YF, Lin TC, Hsu HY. Antioxidant and hepatoprotective

effects of punicalgin and punicalin on acetaminophen -induced

damage in rats. Phytother Res 2001 May; 15(3) : 206-12.

195. Muriel P, Garciapina T, Perez -Alvarez V, Mourelle M. Silimarin

protects against paracetamol - induced lipid peroxidation and liver

damage. J Appl Toxicol1992 Dec; 12(6): 439-42.

196. Xiang ZX, He XQ, Zhou GF, et al. Protective effects of an ethanolic

extract and essential oil of Curcuma kwangsinensis against

experimental liver lesions in mice. Chung Kuo Chung Yao Isa Chih

1989; 14(5): 303,305,320.

233

197. Pulla Reddy Ach, Lokesh BR. Studies on spice principles and anti

oxidants in the inhibition of lipid peroxidation of rat liver microsomes.

Mol Cell Bio Chern 1992;111:117-124.

198. Piper JT, Singhal SS, Salameh MS, et al. Mechanisms of

anticarcinogenic properties of curcumin: the effect of curcumin on

glutathione-linked detoxification enzymes in rat liver Int J Biochem

Cell Bioi 1998; 30(4) : 445-456.

199. Sharma OP. Antioxidant activity of curcumin and related compounds.

Biochern Pharrnacol1976; 25(15): 1811-12.

200. Reddy AC, Lokesh BR. Effect of dietary turmeric (Curcuma Zonga) on

iron induced lipid peroxidation in the rat liver. Food Chern Toxicol

1994; 32: 279-283.

201. Soni KB, Lahiri M, Chackradeo P, et al. Protective effect of food

additives on aflatoxin-induced mutagenicity and hepato-

carcinogenicity. Cancer Lett 1997; 115: 129-133.

202. Chaudhury SK. Influence of Andrographis paniculata (kalmegh) on

bile flow and hexobarbitone sleeping time in experimental animals. Ind

J Exp Bioi 1978: 16: 830-6.

234

203. Ansari RA, Aswal BS, Chander R, Dhawan BN, Gark NK, et al.

Hepatoprotective activity of Picrorrhiza kurroa. Ind J Exp BioI 1997;

35: 1302-15.

204. James Eason, Ellis Williams, Orisa Haas and Timothea Beckerman.

Hepatitis C Focus. In: Campaign America, Home News Articles; Sept.

25,2003.

205. Savita Srivastava, Aravind K Srivastava, Sudhir Srivastava, GK,

Patnaik, BN Dhawan. Effect of picroliv and silymarin on liver

regeneration in rats. Ind J Pharmacol 1994; 26: 19-22.

206. S Srivastava, AK Srivastava, GK Patnaik, BN Dhawan. Effect of

picroliv on liver regeneration in rats. Fitoterapia 1996; Vol. LXVII (3):

252-56.

207. Singh V, Kapoor NK, Dhawan BN. Effect of Picroliv on protein and

nucleic acid synthesis. Ind J Exp Biolo 1992; 30: 68-9.

208. Sonnenbichler J, Goldberg M, Hane L, et al. Stimulatory effect of

bilirubin on the DNA synthesis in partially hepatectomised rat livers:

non response in hepatoma and other malignant cell lines. Biochem

PharmacoIl986; 35: 538-41.

209. Sonnenbichler J ,Zetl I. Biochemical effects of the flavolignan silibinin

on RNA, protein and DNA synthesis in rat livers. In: Cody V,

235

Middleton E and Harbourne JB.(ed).Plant flavonoids in Biology and

medicine; Biochemical, Pharmacological and structure activity

relationships. New York: Alan R; List, Inc; 1986:p. 319-331.

210. Susuki H, Ohta Y. Takine T, et al. Effects of Glycyrrhizin on

biochemical test in patients with chronic hepatitis - Double blood trial.

Asian Med J 1984; 26: 423-438.

211. Susuki H, Yamamoto S, Hirayama C, et al. Cinanidanol for HBe­

antigen positive chronic hepatitis: a multicentre, double blind study.

Liver 1986; 6: 35-44.

212. Kanai K, Morioka S, Nakajima T, et al. Treatment of chronic hepatitis

B with recombinant leukocyte interferon and cyanidanol. Gastroenterol

Jpn 1988; 23 : 44-8.

213. Mehrotra K, Rawat S, Kulshreshtha. DK, et al. In vitro studies on the

effect of certain natural products against hepatitis B virus. Ind J Med

Res 1990; 92: 133-138.

214. Thyagarajan SP, Subramoniam S, Thirunalasundar Venkateswarn PS,

Blumberg BS. Effects of Phyllanthus amarus on chronic carriers of

hepatitis B virus. Lancet 1988: 2: 764-6.

236

215. Doshi JC, Vaidya AB, Antarkar DS, et al. A two stage clinical trial of

Phyllanthus amarus in Hepatitis B carriers: failure to eradicate the

surface antigen. Ind J Gastroenterol1994; 13: 7-8.

216. Crance JM, Biziagos E, Passagot J, et al. Inhibition of Hepatitis A

replication in vitro by antiviral compounds. J Med Virol 1990; 31:

155-160.

217. Wang M, Chang H, Li Y., Meng L, Zhao G., Mai K. Herbs of the

genus Phyllanthus in the treatment of chronic hepatitis B: observations

with three preparation from different geographic sites. J Lab Clin Med

1995; 126 (4): 350-52.

218. Jayaram S, Thyagarajan SP. Inhibition of HBsAg secretion from

Alexander cell line by Phyllanthus amarus. Ind J Pathol Microbiol

1996; 39: 211-15.

219. Vaidya AB, Antarkar DS, et al. Picrorrhiza kurrora (Kutki). J Royle

ex. Benth as a protective agent - experimental and clinical studies. J

Postgrad Med 1996; 42: 105-108.

220. Wang BE. Treatment of chronic liver diseases with traditional Chinese

Medicine. J Gastroentero1 HepatoI2000May;( Suppl) E67-70.

237

221. Byung Tac Ahn, Seung Ho Lee, Jai Seup RO and Kyong Soon Lee: A

chemotaxonomic study on Euphorbiaceae in Korean Natural Product

Sciences.vol (l)1995.p. 86.

222. Cardiel JM. The herbaceous species of Acalypha (Euphorbiaceae) of

Colombia. Jard Annals Bot Madrid 1994; 52(2): 151-157.

223. Cardial JM. Tipification of the species of Acalypha (Euphorbiaceae)

described by Jacquin. Jard Annals Bot Madrid 1995;54(2): 230-233.

224. Standley Pc. Acalypha in trees and shrubs of Mexico. Contr US Natl

Herb 1923; 23 (3): 624-632.

225. The Wealth of India. A Dictionary of Indian raw materials and

Industrial products. Publication and Information Directorate, CSIR,

New Delhi 110012.

226. Caius JE. The medicinal and poisonous plants of India. Scientific

publishers. Jodhpur:India; 1986.p.186-87.

227. Kumar and Solomon. Poona agricultural college magazine; 1952-53.

p.43,61.

228. Panthong A., Kanjanapothi D, Taylor WC. Ethnobotanical review of

medicinal plants from Thai Traditional books, Part I. Plants with

antiinflamatory, antiasthmatic and antihypertensive properties. J

Ethnopharmacol 1986 Dec; 18(3): 213-28.

238

229. Chopra RN, Chopra IC, Handa KC, Kapur LD. Chopra's indigenous

drugs of India. Academic publishers: Calcutta; 1994.p. 661.

230. Pushpangadan P and Atal CK. Ethno-medicobotanical investigations in

Kerala. (1) Some primitive tribals of Western Ghats and their herbal

meidicine. J Ethnopharmacol1984 June;II(1):59-77.

231. Madhusudhana Rao Y and Krishnan DR. J of scientific research in

plants and medicine 1982; 3:51-52.

232. Edward Pollock Anshutz (ed) New old and forgotten remedies.

Papers by many writers. Pathogenesies de l'an ,Philadelphia; Jan 2,

1900.

233. KE Vaidyar. Role of Kuppameni in Sidha Vaidya. In: Glympses of

Indian Ethno pharmacology 1986; 99- 107.

234. K Ganapathi Raman,Baradwaj TPR,Purushothaman KK. A pilot study

of kuppameni (Acalypha indica) in swasakasam (bronchial asthma).

Journal of Research in Indian Medicine, Yoga and Hoemeopathy 1979;

14(3-4): 81-86.

235. BN Bhowmick, V Vardhan.Antifungal activity of some medicinal

plants on Curvularia lunata. Indian phytopathology 1981; 34 (3):

385-86.

239

236. BN Bhowmick, V Vardhan. Antimitotic activity of leaf extracts of

some medicinal plants on Drechslera turcica (parts).Biol Bull India

1982;4(1 ):58-60.

237. K. Nisteswar, SC Dhauani, AS Baxi. Preliminary study on the action

ofAcalypha indica Linn, a folklore drug. Nagarjun 1982;26(3):62-63

238. Shanmughasundaram KR, Seethapathy PG,Shanmughasundaram ER.

Annapavala sindhooram, an antiatherosclerotic Indian drug. J

Ethnopharmacol 1983 May; 7(3);247-264.

239. Aswal BS, Bhakuni DS, Goal AK, Kar K, Mehrotra BN, Mukharjee

KC. Screening of Indian plants for Biological acitivity: part x. Ind J

Expt Bioi 1984 Jun; 22(6):312-32.

240. Lambadusuriya SP, Jayantha UK. Acalypha indica induced hemolysis

in G6PD deficiency. Ceylon Med J 1994 March; 39(1):46-47.

241. Sellahewa K. Acalypha indica induced hemolysis in G6PD deficiency

Ceylon Med J 1994 Sep; 39 (3) :145.

242. Senanayake N, Sanmughanathan PS. Acute intravascular haemolysis

in glucose -6-phosphate dehydrogenase deficient patients following

ingestion of herbal broth containing Acalypha indica. Trop Doct

1996 Jan; 26(1):32.

240

243. Perumal Samy R., Ignacimuthu S, Raja DP, "Preliminary screening of

ethnomedicinal plants from India. J Ethnopharmacol 1999 Aug;

66(2):235 -40.

244. Hiremath SP, Rudresh K, Badami S, PatH SB, PatH SR. Post-coital

antifertility activity of Acalypha inidca Linn. J Ethnopharmacol 1999

Nov;67 (3) 253-8.

245. V Gopalakrishnan, KNV Rao, V Loganathan, S Shanmuganathan, VK

Bollu and T Bhavana Sharma, "Antimicrobial Activity of Extracts of

Acalypha indica Linn. Ind J Pharm Sciences 2000Sep-Oct

246. Reddy JS, Rao PR, Reddy MS. Wound healing effects of Heliotropium

indicum, Plumbago zeylanicum and Acalypha indica in rats. J

Ethnopharmocol 2002 Feb; 79 (2):249-51.

247. Banitala Patra, SP Goswami, SK Jalapatra. Acalyphamide, a new

amide and other clinical constituents. Ind J of chemistry 1981; 20 (B):

974-977.

248. Adolf Nahrastedt 'Acalyphin, a cyanogenetic glucoside from Acalypha

indica. Phytochemistry 1982; 21 (1): 101-105.

249. Papers presented for medicinal plants research, University Regensburg,

Fed Rep Germany 23-28 Sept 1985; Acta Argon Sci Hung 1985.

241

250. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal plants

(1980-84).1st ed. Vol III. Central Drug Research Institute Lucknow and

Publications and Information Directorate: New Delhi. 1993. p. 8-9.

251. Asima C, Satyesh CPo The Treatise of Indian Medicinal Plants. (Vol

III) Publications and Information Directorate; New Delhi. 1997.

p.20-22.

252. The Wealth of India. A dictionary of Indian raw materials and

industrial products: Vol 1.Publication and Information Directorate:

CSIR,New Delhi;1998.p. (A-B) : 21.

253. SK Jain. Medicinal Plants. l" ed. National Book Trust India. 1968.p.

7-8.

254. CK Kokate. Practical pharmacognosy. (2nd ed). Vallaba prakashan:

Delhi; 1988.p.111-115.

255. Peach K and Tracey M V. Modern methods of plant analysis.

1995.p. 152,471.

256. Egil Ramstad. Modern pharmacognosy. The Maple press company

York: 1959;p. 32, 112,215,331.-257. William Charles Evans. Quantitative microscopy. In: Trease and

Evans' Pharmacognosy. (l3th Ed) UK: WD Sounders company Ltd;

1996.p. 108-109.

242

258. Pharmacopoeia of India. (3rd ed) 1989;p. PA 74, Appendix XXI: 650.

259. CK Kokate. Evaluation of crude drugs. In: Practical Pharmacognosy.

(2nd ed). Vallabh prakashan, Delhi; 1988.p. 126-128.

260. CK Kokate, AP Purobit, SB Gokhale. "Pharmacognosy." i h ed. Nirali

Prakashan: Pune; 1997.p. 115-116

261. Arthur Osol, Grafton D Chase, Alfonso R Gennaro, Melvin R Gibson,

C Boyd Grauberg (editors). Instrumetnal methods of analysis In:

Remington's Pharmaceutical Sciences. 16th ed. Mack publishing

company: Pennsylvania; 1980.p. 596.

262. McCord, JM and Fridovich I. Superoxide dismutase, an enzymatic

function for erythrocyprin. J Biol Chern 1969; 244: 6049-55.

263. Halliwell B. How to Characterise a biological antioxidant free radical?

Res Commun 1990; 9:1.

264. Okhawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal

tissue by thiobarbituric acid reaction. Anal Biochem 1979; 95:

351-358.

265 r.d d). Ghosh MN. Fundamentals of experimental pharmacology. 2" (e .

Scientific book Ageny :1984.p.16,89, 154-156.

266. Robert Turner A. Screening methods in Pharmacology, Academic

press: New York; 1965.p. 22-41, 302.

243

267. Molly Mathew, KT Shenoy, TV Oopi. Hepatoprotective activity of

Acalypha indica- a comparative evaluation. Drug Lines Jan2002-Jan

2003;5(1&2):5-7.

268. Rao POM, Rao SO, Kumar V. Effects of Hepatogard against carbon

tetrachloride - induced liver damage in rats. Fitoterapia 1993;

LXIV:108-13.

269. Asha VV. Preliminary studies on the hepatoprotective activity of

Mamordica subangulata and Naragamia alata. Ind J Pharmacol

2001;33:276-79.

270. Higgins GH, Anderson RM. Restoration of the liver of the white rat

following partial surgical removal. Arch PathoI1931;12: 186-202.

271. Laurence DR and Bacharach AL. Evaluation of drug activities.

Pharmacometrics 19964;1:145-146.

272. Bowers ON Jr and Jr and McComb RB .Measurementof total alkaline

phosphatase activity in human serum. Clin Chern 1975; 21:1988-95.

273. Berg HU and Horder M. IFCC method for the measurement of

catalytic concentrations of enzymes. Part -3 . IFCC' method for

alanine amino transferase. J Chern Clin Biochem 1980; 18: 521-34.

244

274. Bergmeyer HU, Bowers S Jr, Horder M and Moss DW . Provsional

recommendations on IFCC methods for the measurement of catalytic

concentrations of enzymes. Part II. Clin Chern 1977; 23: 887-99.

275. Lathe GH and Ruthven CRJ. J Clin Path 1958. In :Harold Varley (in

Harold varely, ed). Julab Vazirani for Arnold Heiemann Publisher

:New Delhi. Practical Clinical Biochemistry, 4th ed. 1988;p. 278-279.

276. de la Huerga J, Smetters GW and Sherrick Je. In: Sunderman FW and

Sunderman SW Jr.(editors) Serum proteins and diproteinemias:

Philadalphia; JB Lippincott Co 1964.

277. J Jayaraman. Protein. In: Laboratory manual in Biochemistry. New

Age International Publishers: New Delhi 1981.p.78.

278. Wybenga DR, Giorgio DI, Pileggi JV. Clinical Chemistry 17: 891­

895, 1971. In: Monica chessbrough (Ed) Medical Laboratory Mannuel

for Tropical countries. 2nd edn.1992; p. 465-466m, 468.

279. Giorgio JD. In :Harper and Row. Clinical chemistry ;principles and

Techniques (Ed). Henry J. New York: 1974.p. 416-417,543.

280. Nichans WJ Jr and Samuelson B. Eur J Biochem 1968; 6: 126.

281. Kakkar P, Das Band Viswanathan PN. A modified spectrophotometric

assay for superoxide dismutase. Ind J Biochem Biophys 1984; 21:

130-32.

245

282. In: Methods of Biochemical Analysis,Glick D (Ed). Inter Science.

Maehaly AC and Chance B. Assay of Catalase and Peroxidase .

Methods of Biochemical Analysis. 1954 ; 2:357.

283. Lawrance RA and Burk RF. Glutathione Peroxidase In Selenium

deficient rat liver. Biochem Biophys Res Commun 1976;71: 952-60.

284. Agerguard Nand Jense. P. J Acta Vet Scand 1982; 23:551.

285. Bergmeyer HU . Methods of enzymatic analysis 1965; 875.

286. Benke GM Cheever KL, Mirer FE and Murphy SP.Comparative

toxicity,anticholinesterase action and metabolism of methyl parathione

and parathione in sunfish and mice. Toxicol Appl Pharmacol1974; 28:

97-109.

287. Lowry OH, Rosebrough NJ, Randall RJ, Farr AL. Protein

measurement with the Folins phenol reagent. J Biol Chern 1951; 193:

265-75.

288. Carr 11 and Drekter IJ . J Clin Chern 1956; 2: 353.

289. J Jayaraman. Laboratory Mannual in Biochemistry. International

Publishers: New Delhi. 1981.p. 114-17.

290. Culling CFA. In: Lynchs. Medical Laboratory Technology. WB

Saunders, Philadelphia: 1976.p.876.

246

291. Woolson RF. Statistcal Methods for the analysis for Biomedical data.

John Wilay and Son Inc; NewYork.1987.

292. Johnston DE,Kroening C. Mechanism of early CCl4 toxicity in cultured

rat hepatocytes. Phannacol Toxicol 1998;83: 231-39.

293. Srivastava SP, Chen N.O. Holtzman JL. The in vitro NADPH

dependent inhibition by CCl 4 of the ATP dependent calcium uptake of

hepatic microsomes from male rats. Studies on the mechanism of

inactivation of the hepatic microsomal calcium pumb by the CCh

radical. J BioI chern 1990; 265:8392-9.

294. Cortan RS, Kumar V, Robbins SL. Cell injury and cellular death. In:

Robbin's Pathologic Basis of Diseases.S" Ed. Prisim Book Pvt. Ltd

1994; p. 379-430.

295. Kaplowitz, N, Aw TY, Simon FR, Stolz A. Drug- induced

Hepatotoxicity. Ann Int Med 1986;104:826-39.

296. Rubia E, Hutterer F, Popper H. Cell proliferation and fibre formation

in Chronic CCl4 intoxication. A morphological and chemical study.

Am J Pathol 1963; 42: 715-28.

297. Recknagel RO. Hepatotoxicity: status quo and future prospects.Trends

Pharmacol Sci 1983;4:129-31.

247

298. Wolfgong OHI, Jolly RA , Donarski WJ, Ochoa R, petry TW.

Inhibition of carbon tetrachloride induced lipid peroxidation by novel

antioxidants III rat hepatic microsomes. Dissociation form

hepatoprotective effects in vivo. J Biochem ToxicoI1990;5:167-74.

299. Kapil A, Koul lB. Banerjii SK, Gupta BD. Antihepatotoxic effects of

major diterpenoid constitutents of Andrographis paniculata. Biochem

pharmacol1993; 46: 182-5.

300. Hiwawasam RP, Jayatilaka KA, Pathirana C and Mudduwa LK.

Protective effect of Asteracantha longifolia extract in mouse liver

injury induced by carbontetrachloride and paracetamol. J Pharm

Pharmacol2003 Oct; 55(10) : 1413-18.

301. Shah M, Patel P, Phadke M, Mary Francis and Sane RT.

Evaluation of the effect of aqueous extract from powders of root,

steam, leaves and whole plant of Phyllanthus deblis against CCI4­

induced rat liver dysfunction. Indian Drugs 2002 Jun ; 39(6):333-37.

302. Pandey VN and Chaturvedi GN. Effect of alcoholic extract of Kutkai

(P. kurroa) on experimentally induced abnormalities in the liver of

rabbits. J Res Ind· Med 1968; 3 : 25.

248

303. Adamska T, Mlynarczyk W, Jodynish Liebert J, Bylka W, Matlawska

I. Hepatoprotective effect of the extract and isocytisoside from

Aquilegia vulgaris. Pytother Res 2003 Jun; 17 (6) : 691-96.

304. Villaruel MC, Toranzo EG and Castro JA. Carbon tetrachloride

activation, lipid peroxidation and the mixed function oxygenase

activity of various rat tissues. Toxicol Appl PharmacoL 1971; 4D :331.

305. Tripathi BK, Srivastava S, Rastogi R, Raina D, et al. Hepatoprotecnee

by 3-bromo -6-(4-chlorophenyl)-4-methyl thio- 2H-p}T3JI]-l-<LD11ll'.e

against experimentally induced liver injury in rats. Acta PhamJl31(0)]

Jun;53(2) : 91-100.

306. Srinivasan S, Recknagel RO. Carbon tetrachloride hepatoxicity ]jJID

female rats. Exp Mol Pathol 1971 Oct; 15(2): 268-70.

307. Rodwell VW. In: Martin DW, Mayer P, Gannoor OK (Edr).H~

review of Biochem. zo" ed. Lange Medicinal plUbnnrc:atttii~:

Califomia.1983;p.62.

308. Awang D. Milk Thistle. Can Pharm J 1993; 23:749-54.

309. GHani AU, Janbaz KH. Studies on protective effect of ()JPfelfw,'

scariosus extract on acetaminophen and CC14 induced h~patOl~'X~~~..

Gen Pharmacol 1995 May; 26 (3): 627-31.

249

310. Hoefler C, Fleurentin J, Mortier F, Pelt JM, Guillemain 1. Comparative

Choleretic and hepatoprotective properties of young sprouts of and

total plant extracts of Rosmarinus officinalis in rats. J Ethnopharmacol

1989 Mar-Apr; 19 (2) : 133-43.

311. GHani AU, Janbaz KH. Preventive and curative effects of Artimisia

absinthium on acetaminophen and CCl4-induced hepatotoxicity. Gen

pharm 1995 Mar; 26(2) : 309-15.

312. Sinclair AJ Barnett AH, Lunie J. Free radicals and antioxidant

systems in health and disease. J Appl Med 1991; 17;409.

313. Kellog EW, Fridovich 1. Liposome oxidation and erythrocyte lysis by

enzymatically generated superoxide and hydrogen peroxide. J BioI

Chern 1977;252:6721-28.

314. Fridovich 1. Suproxide dismutase. Ann Rev Biochem 1975;44: 147-59.

315. I.B Koul, A Kapil. Effect of diterpenes from Andrographis paniculata

on antioxidant defense system and lipid peroxidation. Ind J Pharmacol

1994;26:296-300.

316. Keppler D. Liver morphology and enzyme release; further studies in

the isolated perfused rat liver. Schmidt E, Schmidt FW, Mohr J, Otto

P, Vido I, Wrogeman K, Herfarth C. (Editors) In: Pathogenesis and

250

mechanism of liver cell necrosis. 4th ed. Lancester, Medical and

Technical publications 1975;p.147.

317. Pauline T. Dipthi P, Anju B, Kavimani S, Sharma SK , et al. Studies

on toxicity; antistress and hepatoprotective properties of Kombucha

tea. Biomed Environ Sci 2001 Sep; 14(3): 207-13.

318. Cederbaum A I, Cohen G. Subs Ale Actions / Misuse 1981; 2; 269-72.

319. Mithra S.K Seshadri S1, Venkatranganna MU, Gopumadhavan S,

Venkartesha Udupa- Sharma DNK. Effect of HD-03- A herbal

formation inf galectosami induced hepatotoxicity in rats. Ind J Physiol

Phannacol 2000,44;82-86.

320. - Savides MC, Oehme FW. Acetaminophen and its toxicity.J Appl

Toxicol 1983;3:95111.

321. Zhou L, Erickson RR. Holtzman 11 Studies comparing the kinetics of

cysteine conjugation and protein binding of paracetamol by hepatic

microsomes from male mice. Biochem and Biophys Acta 1997;

1335:153-60.

322. Diallo Sall A, Gueya M, Sarr M, N'Diaye AK, N'Diaye M, Faye B.

Effect and mechanism of action of Tinospora bakis roots on biliary

secretion using in vivo models. Dakar Med 1999; 44 (2): 211-14.

251

323. Chandan BK, Sharma AK, Anand KK . Boerhavia diffusa : a study of

its hepatoprotective activity. J Ethnopharmacol 1991 Mar; 31(3) ;

299-307.

324. Aletti MG, Presta M, Ragnotti G. Liver growth after partial

hepatectomy; Influence of phenobarbital administration. Exp Mol

Pathol 1981; 34:216-25.

325. Harwell LH, Weinert TA. Check points: control that ensure the order

of cell cycle events. Science 1989; 246:629-34.

326. Mcintosh JR, Koonce MP,Blow JJ. Mitosis. Science 1989; 246:622-28.

327. Laskey RA,Fainnan MP,Blow JJ.S-phase of the cycle.Science

1989;246:609-21.

328. Compos R, Garrido A, Guerra R, Valenzuela A. Silybin

dihemisuccinate protects against glutathione depletion and lipid

peroxidation induced by acetaminophen on rat liver. Planta Medica

1987;53-135-40.

329. Chander R, Kapoor HK, Dhawan BN. Effect ofpicroliv on glutathione

metabolism in liver and brain of Mastomys natalensis infected with

Plasmodium berghe. Ind J Expt BioI 1992;30:711-14.

330. Stanislaw Burda and Wieslaw Oleszek . Anti oxidant and antiradical

activities offlavonoids. J Algric Food Chem 2001;49:2774-79.

252

331. Chung HS,Chang LC, Lee SK, Shamon LA, et al .Flavonoid

constituents of Chorizanthe diffusa with potential cancer

chemopreventive activity. J Agoric Food Chern 1999;47:36-41.

332. Russo N, Toscano H, Uccella N. Semi empirical molecular modeling

into quercetin reactive site: structural, confirmational and electronic

features. J Agric Food Chern 2000:48:3232-37.

333. Rice -Evans C. Screening of phenolics and flavonoids for antioxidant

activity. In Antioxidant food supplements in Human Health; Packer L,

Hiramatsu M, Yoshikawa T. (Eds) Academic press, San Diego, CA

1999 p. 239-253. Jovanovic SV, Steenken S, Tosic M.Flavonoids as

anti oxidants. J Am Chern SOC 1994; 16; 4846-4851.

334. Jovanovic SV,Steenken S,Tosic M.Flavonoids as anti oxidants.1 Am

Chern Soc 1994;16:4846-51.

335. Bors W, Heller W, Michel C, Saran C, Saran M. Flavonoids as

antioxidants; determination of radical scavenging efficiencies.

Methods Enzymoll990; 186;343-355.

336. Joyenx M, Lobstein A, Anton R, Mortier F. Comparative

antilipoperoxidant , antinecrotic and scavenging properties of terpenes

and biflavones from Ginkgo and some flavonoids. Planta Medica

1995;61: 126-129.

253

337. Sur-Altiner D, Yenice B.Effect of Black Tea on lipid peroxidation in

CC14 treated male rats. Drug Metabol Drug Interact 2000; 16:123-28.

338. Ho CT, Chen Q, Shi H, Zhang KQ, Rosen RT. Antioxidative effect of

polyphenol extract prepared from various Chinese Tea. . Prev Med

1992 July; 21(4): 520-25.

339. Festa F, Aglitti T, Duranti G, et al. Antioxidant activity of ellagic acid

in mammalian cells in vitro revealed by the comet assay. Anti cancer

Res.2001 Nov 21 (6A):3903-8.

340. Wada L, Ou B. Antioxidant activity and phenolic content of Origon

caneberriers. J Agric Food Chern 2002 June:50(l2):3495-500.

341. KR Conca, WL Porter and S Diotte. Antioxidant activity of Mango

puree and its component phenols. 2002 annual meeting and food

Expo.Anaheim;California, session 61 D; Neutracetical and functional

Foods II

342. Anand KK, Singh B, Saxena AK. Chandan BK, et al. 3,4,5­

trihydroxy benzoic acid (gallic acid) - the hepatoprotective principle

in the fruits of Terminalia balerica - bioassay guided activity.

Pharmacol Res 1997 Oct; 36(4) :315-321.

343. Thresiamma KC, Kuttan R. Inhibition of liver fibrosis by ellagic

acid. Ind J Physiol Pharmacol 1996 Oct; 40(4): 363-6.

254

344. Thresiamma KC, George J, Kuttan R. Protective effect of curcumin,

ellagic acid and bixin on radiation- induced toxicity. Ind J Exp Biol

1996 Sep ~ 34(9): 845-47.

345. Camps J, Bargallo T, Gimenerz A. Alie S. Caballeria J, pares A, Joyen

J et al Relationship between hepatic lipid peroxidation and fibrogenesis

in CCI4- treated rats; effect of Zinc administration. Clinical science

1992~83:695-70'O.

A. indica

ALKP

ALT

AST

CCh

CHCh

CMC

Cy P450

DMSO

DNA

DTNB

GSH

GSSG

H202

IC50

MDA

MFOS

NADP

NAPQI

O2 CCl 3

O~

RBC

RNA

ROS

SOD

TBA

TCA

Abbreviations

Acalypha indica

Alkaline Phosphatase

Alanine amino Transferase

Aspartate Amino Transferase

Trichloromethyl Radical

Chloroform

Carboxy Methyl Cellulose

Cytochrome P450

Dimethyl Sulphoxide

Deoxyribo Nucleic Acid

5,5 thiobis (2 - nitrobenzoic acid)

Reduced Glutathione

Oxidised glutathione

Hydrogen Peroxide

50% inhibitory concentration

Malondialdehyde

Mixed Function Oxidase System

Nicotinamide Adenine Dinucleotide Phosphate

N - Acetyl- p - benzoquinone - imine

Trichloromethyl Peroxy Radical

Superoxide Anion Radical

Red Blood Corpuscle

Ribo Nucleic Acid

Reactive Oxygen Species

Superoxide Disrnutase

Thiobarbituric Acid

Trichloro Acetic Acid