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BACKGROUND
The Advanced Molecular Pathology Laboratory (AMPL) is a joint e�ort between the Institute of Molecular and Cell Biology (IMCB) and SingHealth. The facility provides a wide range of pathology-related services in basic and translational research, therapeutic target validation and drug safety evaluation for biomedical research.
KEY OBJECTIVES
Provide pathology services as a one-stop facility for researchers as well as pharmaceutical and biotechnology companies that engage in exploratory, preclinical and early clinical studies.
Generate quality tissue bio resources in collaboration with SingHealth Tissue Repository (STR).
CORE STRENGTHS & SERVICES
AMPL@SingHealth provides pathology services as a one-stop facility for pharmaceutical and biotechnology companies. This is for both animal tissue and human tissue based research. Animal research services include GLP-grade animal necropsy, histology services, immunohistochemistry, in situ hybridization, image analysis and veterinary pathology evaluation.
At AMPL, researchers also have access to a CAP-compliant diagnostic facility with a variety of techniques necessary for human tissue-based research including histotechnology, histopathology consultation, immunodiagnostics and molecular assays. AMPL is also closely linked to the SingHealth Tissue Repository (the largest human tissue research biobank in Singapore).
Why use our services?
Our veterinary pathologists are either board certi�ed by American College of Veterinary Pathologists (ACVP) or American Board of Toxicology (ABT), with decades of experience in the pharmaceutical industry. AMPL is headed by an experienced histopathologist with local license and international quali�cations. We also provide consultation for project design, applications to IRB and tissue access committees. Our charges are competitive and we ensure 100% quality control.
OUR PARTNERSHIP
Institute of Medical Biology – Microscopy Unit (IMU) is a core technology platform of the Institute of Medical Biology, whose mission is to provide light and electron microscopy equipment. It o�ers image processing, analysis software and expertise to facilitate research in molecular, cell and developmental biology. IMU focuses on seven areas of advanced imaging:
3D imaging including light sheet imaging
F-techniques (FRET, FRAP, FLIM and FCS)
High content imaging
Live-cell imaging
Super-resolution microscopy (PALM, dSTORM and SIM)
Electron microscopy for details
Image analysis & processing
Rodent necropsy and veterinary pathology
Pathology and histological consultation
Immunodiagnostics
TUNEL assays for apoptosis
RNA In Situ Hybridisation (ISH) assays
Tissue microarray construction
Cellular array construction
Fluorescence In Situ Hybridisation (FISH)
Laser capture micro-dissection
Nucleic acid extraction
Antibody and probe evaluation services
Digital pathology and image analysis - Partnership with Institute of Molecular and Cell Biology (IMCB)
Type of Services
Tissue microarray construction process
DIRECTOR’S BIO
Assoc. Prof Tan Soo Yong is Director of SingHealth Tissue Repository (STR) and also heads Advanced Molecular Pathology Laboratory (AMPL). He is also Senior Principal Investigator at the Institute of Cell and Molecular Biology (IMCB), Chief Examiner in Pathology, Chairman of the Residency Advisory Committee for Pathology and Visiting Professor to University Malaya.
He is currently Associate Professor in Duke-NUS Graduate Medical School Singapore, a Senior Consultant and Clinician Investigator in the Department of Pathology, Singapore General Hospital and Senior Consultant to the Ministry of Health, Singapore. A member of the International Lymphoma Study Group (ILSG), his current research interest is in the pathology of NK/T cell and epitheliotropic intestinal T-cell lymphoma.
The content is correct at the time of printing.©2015 SingHealth O�ce of Research. All rights reserved.
–Human tissue-based bioresources and research servicesAMPL@SingHealth
20 College Road,The Academia,Discovery Tower, Level 10 Singapore 169856
For enquiries and research services, please contact:Tel: (+65) 6576 7116Email: [email protected]
–Animal tissue-based bioresources and research servicesAMPL@Biopolis
61 Biopolis Drive,Proteos Building Level 6Singapore 138673
For enquiries and research services, please contact:Tel: (+65) 6586 9629Email: [email protected]
