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Spotfire DecisionSite Overview Dylan Cotter Application Specialist, Business Development [email protected]
Spotfire DecisionSite Overview
Dylan CotterApplication Specialist, Business Development
Spotfire Overview• Leader in Guided Analytic Applications and Services• 700+ Global 2000 Customers; 25,000+ users• 160+ World Wide Employees- Sales and Support• Headquartered in Somerville, MA and Göteborg, Sweden• Dominant in life science
– All major Pharmas + 250 Biotechs– Discovery: Proteomics, Genomics, HTS, Lead
Optimization, ADME/Tox– Development: Clinicals, Pilot, Manufacturing, Supply-
chain, Sales/Marketing
Product Overview Access to any data
– One-click data retrieval to ad-hoc querying
– Integrated– Multiple sources– Unified data view
Continuous data exploration and analysis
– Linked Visualization– Dynamic filtering– One-click analytic formulae
and computations– Drill down to details
DecisionSite PostersEnable teams to collaborate around data driven decisions
– Across geographies, – Across time zones– Across boundaries– Across disciplines
Extends the value of Guided Analytics across the enterprise to facilitate better, faster team decision-making
• Manages decisions as company assets creating Decision I.P.™
• Interactively filters data via range sliders, check boxes, or radio buttons with dynamic detail drill down
DecisionSite BenefitsUnifies information from
multiple sources into a single analytic interfaceProvides access to specific analytical tools to understand and interpret scientific dataEnvironment appropriate for specialists and end users
– Fast learning curve– Powerful analytics capabilities
Environment configurable for integration with existing core infrastructureCaptures critical analysis and decision IP™
Information links
DecisionSite Architecture
Information Interaction ServicesDecisionSite Server
DatamartOracle
DB
DecisionSite Browser
OracleModel StoreJoin Engine
JDBC
Oracle Features Used TodaySpotfire DecisionSite Server supports Oracle Enterprise/Standard Databases:
- Oracle9i Release 2 (9.2.0.x)- Oracle9i Release 1 (9.0.1)- Oracle8i Releases 8.1.7 and 8.1.6.
DecisionSite’s Information Interaction Services uses Oracle as as federated database access Query and Join Engine for multiple and disparate database accessStorage of the Meta Layer of Disparate data sources as an Information model that is a business representation of data sources
Oracle Features UsedUse of Oracle SQL functions for data manipulations
Oracle Chemistry cartridges in combination with partner companies provide:
– Chemical Storage technologies– Chemical content repositories– Integration capabilities– Screening data repositories
New in the DecisionSite 8.0 Release
Support for Oracle 10g
Enhanced Information Link APIs for Oracle name resolver service provides row level security to data retrieved for analysis
1. High-Throughput ScreeningSpotfire configuration
– High Throughput ScreeningShared users
– Biologists in primary & secondary screening
Solution Business Impact– Automated workflow/processing
of high throughput screening data– Multiple views and slices of the
processed data revealing inconsistencies
– Best practices for analyzing HTS data are institutionalized
– Better quality/confidence leads delivered to secondary screening and medicinal chemistry
2. Lead IdentificationSpotfire configuration
– Chemogenomic analyticsShared users
– Toxicologists, pharmacologists, chemists
Solution Business impact– Identify compounds with similar gene
expression signatures (“fingerprints”) – Incorporate chemical structure,
clinical chemistry and histopathology data into the analysis to better define relationships between compounds
– Use compound relationships to anticipate toxic behavior in unknown compounds
3. Compound ProfilingSpotfire configuration
– Lead DiscoveryShared users
– Medicinal ChemistsBusiness impact
– Compounds profiled acrossdepartmental and domain borders
– Chemists get insight into biology, biologists insight into chemistry
– Best practices for compound selection can be institutionalized
– Better quality leads delivered to ADME/Tox / pre-clinical areas
4. Functional GenomicsSpotfire configuration
– microarray data analysisShared users
– Biologists in target discoveryBusiness impact
– Identify data sources– Select methods of data
transformation– Incorporate appropriate tools
analysis to test hypothesis– Add known information to extend
the analysis– Identify subsets of genes for
further study– Decision process involves
identifying subsets of genes for further study, accept or reject hypothesis and share conclusions
5. Clinical Trials – Phase I, II, IIISpotfire configuration
– Adverse Event AnalysisShared users
– Clinical trial/data managers, statisticians, and medical monitors
Business impact– Identify types/frequency of adverse
events– Outliers indicating errors in data
recording– Explore frequency/severity of adverse
events, demographic influences, statistically significant dependencies between event type and dosage
– Issues in clinical trials can be detected earlier
6. Pharmaceutical Sales & MarketingSpotfire configuration
– Pharmaceutical Sales & MarketingShared users
– Business analysts, brand/product managers, sales/marketing managers
Business impact– Leverage very expensive IMS into
analytic environment– Drive informed sales force
deployment decisions– Integrate IMS / prescription data,
patient demographics, physician data, and GIS data
– Market and sell in area where effect is optimal
Analytic Applications Support Many Needs
Toxicogenomics
Compare microarray and rtPCR data
Extend the Analysis:– Validate microarray
results with rtPCR– Compare gene
expression with protein expression
– Chemogenomics: integrate chemistry support
– Toxicogenomics: integrate Toxicology data
Chemogenomics
Protein expression
SummaryPowerful data access
– access to many data sourcesState of the art visualizations
– multiple, linked, dynamic plotsEasy to use
– intuitive UI, Guides Extend analysis methods
– deploy new algorithms or toolsDevelop new Analytic Applications
– support future analysis processes
Share decisions– dynamic, interactive reports
Contact InformationThank you for your attention!
www.spotfire.com
/freedom to wonder_power to decide
