Subject index to volume 22*1

Subject Index to Volume 22*

A

Abnormal expression Abnormal expression of PDC-E2 on the

apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis (Tsuyenama et al). 1995;22:1440-6

Absolute e thanol Portal vein embolization with steel coils

and absolute ethanol:a comparative experimental study with canine liver (Yamakado et al). 1995;22:1812-8

Acetaldehyde Sequential acetaldehyde production, lipid

peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease (Niemel~i et al). 1995;22:1208- 14

Acetaminophen Acetaminophen-induced microvascular

injury in the rat liver: protection with misoprostol (Lim et al). 1995;22:1776- 81

Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure (Zimmerman and Mad- drey). 1995;22:767-73

Sulfation of acetaminophen by the perfused rat liver: the effect of red blood cell carriage (Pang et al). 1995;22:267-82

Acetylaminofluorene Oval cell differentiation into hepatocytos

in the acetylaminofluorene-treatod regenerating rat liver (Golding et al). 1995;22:1243-53

Acetylcholine Acetylcholine-induced vasorelaxation in

portal hypertensive rats (Michielsen et al) (Letter); (Jimdnez) (Reply). 1995;22:1009-11

N.Acetylcysteine Protective effects of N-acetylcysteine on

hypothermic ischemia-reperfusion injury of rat liver (Nakano et al). 1995;22:539-45

N-Acetylglucosaminyltransferases IH- IV

Gene expression of N-acetylglucosaminyltransferases III and IV: a possible im- plication for liver regeneration (Miy- oshi et al). 1995;22:1847-55

Acute effects Dynamic measurements of the acute and

chronic effects of lysosomotropic agents on hepatocyte lysosomal pH using flow cytometry (Myers et al). 1995;22:1519-26

Acute feeding N-Ethyl-tauroursodeoxycholic acid, a

novel deconjugation-resistant bile salt analogue: effects of acute feeding in the rat (Angelico et al). 1995;22:887-95

Adenine arabinoside monophosphate Inhibition of woodchuck hepatitis virus

replication by adenine arabinoside monophosphate coupled to lactosami- natod poly-L-lysine and administered by intramuscular route (Flume et al). 1995;22:1072-7

Adenine nucleotides The effect ofprostaglandin E1 on liver ade-

nine nucleotides and cytoplasmic enzymes in a porcine model of normothermic hepatic ischemia (Helling et al). 1995;22:1554-9

Adenoma Management of focal nodular hyperplasia

and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations (Cherqui et al). 1995;22:1674-81

S-Adenosylmethionine Carbon tetrachloride-induced hepatic in-

jury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment (Varela-Moreiras et al). 1995;22:1310-5

Adenovirus Induction of sensitivity to ganciclovir in

human hepatoceUular carcinoma cells by adenovirus-mediatod gene transfer of herpes simplex virus thymidine kinase (Qian et al). 1995;22:118-23

Adolescents Chronic hepatitis and hepatic failure in a

14-year-old girl (Ludwig et al). 1995;22:1874-9 (Clinicopathology conference)

The liver in adolescents with al-antitrypsin deficiency (Sveger and Eriksson). 1995;22:514-7

Adriamycin Specific targeting of adriamycin conju-

gates with monoclonal antibodies to hepatoma associated antigens to in-

* July, 1-380; August, 381-686; September, 687-1020; October, 1021-1350; November, 1351-1622: De- cember, 1623-1954.

1918

trahepatic tumors in athymic mice (Adler et al). 1995;22:1482-7

Adults Effect of anti-ulcer drugs on DNA synthe-

sis in adult normal human hepatocytes in culture (Blanc et al). 1995;22:814-9

Prevalence of hypertransaminasemia in adult celiac patients and effect of glu- ton-free diet (Bardella et al). 1995;22:833-6

Adverse drug reactions Diclofenac-associated hepatotoxicity:

analysis of 180 cases reported to the Food and Drug Administration as adverse reactions (Banks et al). 1995;22:820-7

Aflatoxin B1 p53 proteins and aflatoxin BI: the good,

the bad, and the ugly (Liang). 1995;22:1330-2 (Editorial)

Age Effect of donor age and sex on the outcome

of liver transplantation (Marino et al). 1754-62

The significance of spontaneous hepatitis B e antigen seroconversion in child- hood; with special emphasis on the clearance of hepatitis B e antigen before three years of age (Chang et al). 1995;22:1387-92

A 28-year-old woman with a combined he- paticJcholestatic syndrome (Wurbs et al). 1995;22:1598-1605 (Clinicopa- thology conferences)

Aggregation, focal lymphocytic Focal lymphocytic aggregates in chronic

hepatitis C: occurence, immunohistochemical characterization, and relation to markers of autoimmunity (Freni et al). 1995;22:389-94

Aggregation, vesicle Mucin-vesicle interactions in model bile:

evidence for vesicle aggregation and fusion before cholesterol crystal formation (Afdhal et al). 1995;22:856-65

Albumin Beneficial effects of intravenous albumin

infusion on the hemodynamic and humoral changes after total paracento- sis (Luca et al). 1995;22:753-8

Alcohol Acetaminophen (paracetamol) hepatotox-

icity with regular intake of alcohol: analysis of instances of therapeutic misadventure (Zimmerman and Mad- drey). 1995;22:767-73

Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat (Bauer et al). 1995;22:1565-76

HEPATOLOGY Vol. 22, No. 6, 1995 SUBJECT INDEX 1919

Serum carbohydrate-deficient transferrin; mechanism of increase after chronic alcohol intake (Xin et al). 1995;22:1462-8

Alcoholism Immune mechanisms of alcohol-induced

liver disease (Klassen et al). 1995;22:355-7 (Editorial)

An investigation of whether polymorphisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population (Chao et al). 1995;22:1409-14

Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis (Yamauchi et al). 1995;22:1136-42

Relationship between cardiomyopathy and liver disease in chronic alcoholism (Estruch et al). 1995;22:532-8

Role of defective monocyte intorleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis (Le Moine et al). 1995;22: 1436-9 alcohol-induced liver disease (Niemel~ et al). 1995;22:1208-14

Alcoholism, experimental Cytokine gene expression by Kupffer cells

in experimental alcoholic liver disease (Kamimura and Tsukamoto). 1995;22:1304-9

Aldosterone Effect of upright posture and physical ex-

ercise on endogenous neurohormonal systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldosterene, and norepinephrine levels (Sal5 et al). 1995;22:479-87

Allografts Does interferon precipitate rejection of

liver allografts (Min and Boden- heimer)? 1995;22:1333-5 (Editorial)

Terminology for hepatic allograft rejection (International Working Party). 1995;22:648-54 (Special article)

a-fetoprotein A clinical study of lectin-reactive alpha

fetoprotoin as an early indicator ofhepatocellular carcinoma in the follow- up of cirrhotic patients (Shirake et al). 1995;22:802-7

Downregulation of phorbol 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-l~ production and gene expression in human monocytic cells by human alpha- fetoprotein (Wang and Alpert). 1995;22:921-8

Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by a-feteprotein but not insulinlike growth factor II regulatory sequences (Arbuthnot et al). 1995;22:1788-96

Alterations An array of mitochondrial alterations in

the hepatocytes of Long-Evans cinnamon rats (Sternlieb et al). 1995;22:1782-7

Integration of hepatitis B virus and alter- ation of the lp36 region found in can- cerous tissue of primary hepatocellular carcinoma with viral replication evidenced only in noncancerous, cirrhotic tissue (Simon and Carr). 1995;22:1393-8

Alveolar echinococcosis Alveolar echinococcosis (Mosimann et al)

(Letter); (Ammann) (Reply). 1995;22:1007-9

Amino acids Effects of branched-chain amino acid infu-

sion on protein metabolism in rats with acute hepatic failure (Miwa et al). 1995;22:291-6

Amino terminus Humoral response to linear B cell epitopes

in the amino terminus of the hepatitis C virus envelope glycoprotein gp72 (E2): Role in protective immunity still unknown (Weiner). 1995;22:369-71 (HEPATOLOGY Elsewhere)

Anastomosis Disruption of circadian locomotor activity

in rats after portocaval anastomosis is not gender dependent (Steindl et al). 1995;22:1763-8

Anemia Aplastic anemia after liver transplanta-

tion (Collins and Klintmalm) (Letter); (Cattral and Langnas) (Reply). 1995;22:1611-12

Parvovirus B19 as a possible causative agent of fulminant liver failure and associated aplastic anemia (Langnas et al). 1995;22:1661-5

Reduced serum levels of immunoreactive erythropoietin in patients with cirrhosis and chronic anemia (Siciliano et al). 1995;22:1132-5

Anesthesia Nitric oxide donor prevents hepatic and

systemic perfusion decrease induced by endotoxin in anesthetized rabbits (Pastor et al). 1995;22:1547-53

Angtotensin H receptors Loss of angiotonsin-II receptors in portal

hypertensive rabbits (Sitzmann et al). 1995;22:559-64

Antibodies Abnormal expression of PDC-E2 on the


Anti-hepatitis B virus activity of a mix- ture of two monoclonal antibodies in an "inhibition in solution" assay (Heijtink et al). 1995;22:1078-83

Efficacy of screening donors for antibodies to the hepatitis C virus to prevent transfusion-associated hepatitis: fi- nal report of a prospective trial (Gon- z~lez et al). 1995;22:439-45

Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2) (Ahmed et al).

Immunoglobulin M antibody to hepatitis C virus core antigen: correlations with viral replication, histological activity, and liver disease outcome (Quiroga et al). 1995;22:1635-40

The significance of immunoglobulin M antibody response to hepatitis C virus core protein in patients with chronic hepatitis C (Yukim et al). 1995;22:402-6

Specific targeting of adriamycin conjugates with monoclonal antibodies to hepatoma associated antigens to intrahepatic tumors in athymic mice (Adler et al). 1995;22:1482-7

Uridine diphosphate glucuronosyl transferases, candidate antigens of liver- kidney microsomal antibodies in hepatitis delta virus-infected patients (Bonino and Brunetto) 1995;22:674-6 (HEPATOLOGY Elsewhere)

Antigens Induction of T-helper cell response to hep-

atitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus (Marinos et al). 1995;22:1040-9

Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes (Amouzadeh and Pohl). 1995;22:936- 43

The significance of spontaneous hepatitis B e antigen seroconversion in child- hood; with special emphasis on the clearance of hepatitis B e antigen before three years of age (change et al). 1995;22:1387-92



Antimitochondrial antibodies Abnormal expression of PDC-E2 on the

apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary bili-

1920 SUBJECT INDEX HEPATOLOGY December 1995

ary cirrhosis (Tsuyanama et al). 1995;22:1440-6

Antioxidative capacity Reduced antioxidative capacity in liver

mitochondria from bile duct ligated rats (Kr/ihenbfihl et al. 1995;22:607- 12

Antipyrine clearance Antipyrine clearance and response to in-

terferon treatment in patients with chronic active hepatitis C (Coverdale et al). 1995;22:1065-71

Antisense oligonucleotides Specific inhibition of hepatitis C viral

gene expression by antisense phosphorothioate oligodeoxynucleotides (Alt et al). 1995;22:707-17

al-Anti t rypsin deficiency The liver in adolescents with ~l-antitryp-

sin deficiency (Sveger and Eriksson). 1995;22:514-7

Wherefore art thou liver disease associated with alpha-1 antitrypsin deficiency (Sharp)? 1995;22:666-8 (Edito- rial)

Anti-ulcer drugs Effect of anti-ulcer drugs on DNA synthe-


Antiviral agents Effect of immunosuppressive and antivi-

ral agents on hepatitis B replication in vitro (McMillan et al). 1995;22:36- 43

Antiviral effects An open trial of interferon alfa recombi-

nant for hepatitis C after liver transplantation: antiviral effects and risk of rejection (F~ray et al). 1995;22:1084-9

Aorta Endothelium-dependent vascular hypore-

sponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats (Weigert et al). 1995;22:1856-62

AP-1 transcription factor Differential activation of transcription

factors NK-KB and AP-1 in rat liver macrophages (Tran-Thi et al). 1995;22:613-9

Apical surface Abnormal expression of PDC-E2 on the


Aplastic anemia Aplastic anemia after liver transplanta-

tion (Collins and IGintmalm) (Letter); (Cattral and Langnas) (Reply). 1995;22:1011-12

Parvovirus B19 as a possible causative agent of fulminant liver failure and

associated aplastic anemia (Langnas et al). 1995;22:1661-5

Apoptosis Phenobarbital modulates the type of cell

death by rat hepatocytes during dep- rivation of serum in vitro (Chiao et al). 1995;22:297-303

Transforming growth factor zl increases the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes (Benedetti et al). 1995;22:1488-97

L-Arginine Systemic hypertension and diuresis by L-

arginine in cirrhotic patients with ascites; role of nitric oxide (Tajiri et al). 1995;22:1430-5

Array An array of mitochondrial alterations in


Arterial bed, forearm Inhibition of nitric oxide synthesis in the

forearm arterial bed of patients with advanced cirrhosis (Campillo et al). 1995;22:1423-9

Arterial embolization Changes in platelet kinetics after a partial

splenic arterial embolization in cirrhotic patients (Nognchi et al). 1995;22:1682-8

Arterial ketone body ratio In defense of the arterial ketone body ratio

(Saibara) (Letter); (Kawasaki) (Re- ply). 1995;22:1004-7

Ascorbate Ascorbic acid inhibits chemically induced

uroporphyria in ascorbato-requiring rats (Sinclair et al). 1995;22:565-72

Ascites Blunted natriuretic response to low-dose

brain natriuretic peptide infusion in nonazotemic cirrhotic patients with ascites and avid sodium retention (La Villa et al). 1995;22:1745-50

Increased production of nitric oxide by neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation (Laffi et al). 1995;22:1666-73

Ascorbic acid Ascorbic acid inhibits chemically induced

uroporphyria in ascorbate-requiring rats (Sinclair et al). 1995;22:565-72

Asialoglycoprotein receptor In vivo transfection of hepatitis C virus

complementary DNA into rodent liver by asialoglycoprotein receptor mediated gene delivery (Yamamoto et al). 1995;22:847-5

Ascites Long-term effect of nadolol or nadolol plus

isosorbide-5-mononitrate on renal function and ascites formation in pa-

tients with cirrhosis (Merkel et al). 1995;22:808-13

Systemic hypertension and diuresis by L- arginine in cirrhotic patients with ascites; role of nitric oxide (Tajiri et al). 1995;22:1430-5

Ascites, refractory Transjugular intrahepatic portosystemic

shunt for refractory ascites: tipping the sodium balance (Wong and Blendis). 1995;22:358-65 (Editorial)

Transjugular intrahepatic portosystemic shunt: is it the ultimate solution for refractory ascites (Wong and Blendis)? 1995;22:1613-15 (HEPA- TOLOGY Elsewhere)

Treatment of patients with cirrhosis and refractory ascites using LeVeen shunt with titanium tip: comparison with therapeutic paracentesis (Gin,s et al). 1995;22:124-31

Associations Organellar clusters formed by mitochon-

drial-rough endoplasmic reticulum associations: an ordered arrangement of mitochondria in hepatocytes (Cas- carano et al). 1995;22:837-46

Athymic mice Specific targeting of adriamycin conju-

gates with monoclonal antibodies to hepatoma associated antigens to intrahepatic tumors in athymic mice (Adler et al). 1995;22:1482-7

Atlas Text and atlas of endoscopic retrograde

cholangiopancreatography (Marcel). 1995;22:677-8 (Book review)

Atrial natriuretic peptide (ANP) High plasma levels of atrial natriuretic

peptide in preascitic cirrhosis: indi- rect evidence of reduced natriuretic effectiveness of the peptide (Trevisani et al). 1995;22:132-7

Reversal of atrial natriuretic peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis (Abraham et al). 1995;22:737-43

Autoantibodies Autoantibodies to BCOADC-E2 in pa-

tients with primary biliary cirrhosis recognize a conformational epitope (Leung et al). 1995;22:505-13

Efficacy and safety of interferon alfa therapy in chronic hepatitis C with autoantibodies to liver-kidney microsomes (Todros et al). 1995;22:1374-8

Autoimmune hepatitis Autoimmune hepatitis (Reddy).

1995;22:1616-7 (Book review) Evidence for spontaneous immunosup-

pression in autoimmune hepatitis (Lohse et al). 1995;22:381-8

Hepatocellular carcinoma complicating autoimmune hepatitis: role of hepati-


tis C virus (Ryder et al). 1995;22:718- 22

Limited usage of T-cell receptor B chains and sequences of the complementarity determining region 3 of lymphocytes infiltrating in the liver of autoimmune hepatitis (Hoshino et al). 1995;22:142-7

Autoimmunity Focal lymphocytic aggregates in chronic

hepatitis C: oecurence, immunohiste- chemical characterization, and relation to markers of autoimmunity (Freni et al). 1995;22:389-94

Autologous hepatotoxicity T-cell-mediated autologous hepatetoxicity

in patients with chronic hepatitis C virus infection (Liaw et al).

1995;22:1368-73 Autopsy

Intrahepatic cholangiographie appear- ance simulating primary sclerosing cholangitis in several hepatobiliary diseases: a postmortem cholangiographic and histopathologica] study in 154 livers at autopsy (Terada and Nakanuma). 1995;22:75-81

Avid sodium retention Blunted natriuretic response to low-dose


B

Bacterial infection Macrophage function in cirrhosis and the

risk of bacterial infection (Guarner and Runyon). 1995;22:367-8 (HEPA- TOLOGY Elsewhere)

Bacterial peritonitis Ciprofloxacin and long-term prevention of

spontaneous bacterial peritonitis: re- suits of a prospective controlled trial (Relachon et al). 1995;22:1171-4

B cell epitopes, linear Humoral response to linear B cell epitopes


BCOADC-E2 Auteantibodies to BCOADC-E2 in pa-


Behavioral responses Defective corticotropin-releasing hormone

mediated neuroendocrine and behavioral responses in cholestatic rats; implications for cholestatic liver disease-related sickness behaviors (Swain et al). 1995;22:1560-4

fl-adrenergic receptors

Cardiac plasma membrane physical prop- erties and fl-adrenergic receptor hmc- tion are unaltered in portal-hypertensive rats (Ma et al). 1995;22:188-93

Beta chain variable region genes The influence of a maternal chronic hepa-

titis B virus infection on the repertoire of transcribed T-cell receptor beta chain variable region genes in human cord blood (Abbott et al). 1995;22:1034-9

Bile Deoxycholic acid influences cholesterol

solubilization and microcrystal nucleation time in gallbladder bile (Hus- saini et al). 1995;22:1735-44

Effects of liver transplantation on bile formation and biliary lipid secretion in the Sprague-Dawley rat (Chan et al). 1995;22:1254-8

Excretion of F2-isoprostanes in bile: a novel index of hepatic lipid peroxidation (Awad and Morrow). 1995;22:962-8

Inhibition of gallbladder emptying decreases cholesterol saturation in bile in the Richardson ground squirrel (Pauietzki et al). 1995;22:325-31

Bile, model Mucin-vesicle interactions in model bile:


Bile acid analogues, fluorescent conjugated

Transport characteristics of three fluorescent conjugated bile acid analogs in isolated rat hepatocytes and couplets (Maglova et al). 1995;22:637-47

Bile acids Hepatebiliary transport of hepatic 3-hy-

droxy-3-methylglutaryl coenzyme A reductase inhibiters conjugated with bile acids (Petzinger et al). 1995;22:1801-11

Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7a-hydroxylase and sterol 27-hydroxylase (Shefer et al). 1995;22:121

Bile duct cancer p53 protein immunoreactivity in extrahe-

patic bile duct and gallbladder cancer: correlation with tumor grade and survival (Diasmantis et al). 1995;22:774- 9

Bile duct development, intrahepatic Expression of glycoconjugates during in-

trahepatic bile duct development in the rat: an immunohistochemical and lectin-histochemical study (Sanzen et al). 1995;22:944-51

Bile duct epithelial cells Toyota T. Confluent monolayers of bile

duct epithelial cells with tight junctions (Okamoto et al). 1995;22:153-9

Bile duct-Hgated rats Downregulation of male-specific cyto-

chrome P450s 2Cl l and 3A2 in bile duct-ligated male rats: importance to reduced hepatic content of cytochrome P450 in cholestasis (Chen et al). 1995;22:580-7

Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats (Kr~ihenbtihl et al. 1995;22:607- 12

Bile ductules, intrahepatic Brefeldin A inhibits the transcytotic vesic-

ular transport of horseradish peroxidase in intrahepatic bile ductuies isolated from rat liver (Benedetti et al). 1995;22:194-201

Bile salt analogue N-Ethyl-tauroursodeoxycholic acid, a


Bile salt uptake Tumor necrosis facter-alpha decreases he-

patocyte bile salt uptake and medi- ates endotoxin-induced cholestasis (Whiting et al). 1995;22:1273-8

Biliary excretion Impaired biliary excretion and whole body

elimination of methylmercury in rats with a congenital defect in biliary glutathione excretion (Ballatori et al). 1995;22:1469-73

Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes (Nakano et al. 1995;22:262-6

Biliary lipids Effects of liver transplantation on bile for-

mation and biliary lipid secretion in the Sprague-Dawley rat (Chan et al). 1995;22:1254-8

Biliary research Methods in biliary research (Apstein).

1995;22:1617 (Book review) Biliary tract

Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitechon- drial antibody-negative primary biliary cirrhosis (Tsuyenama et al). 1995;22:1440-6

Surgery of the liver and biliary tract (Rossi). 1995;22:1616 (Book review)

Binding Spl binding activity increases in activated

Ito cells (Rippe et al). 1995;22:241-51 74

Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding (Liu et al). 1995;22:1474-81

Biology The Liver. Biology and Pathobiology. Ed


3 (Riely et al). 1995;22:372 (Book review)

Biomatrix proteins, hepatic Rat hepatocytes attach to laminin present

in liver biomatrix proteins by an Mg+÷-dependent mechanism (De Lourdes Ponce and Rojkind). 1995;22:620-8

Blood The influence of a maternal chronic hepa-


Blood f low autoregulation Cerebral blood flow autoregulation and

transcranial Doppler sonography in patients with cirrhosis (Stolze Larson et al). 1995;22:730-6

Blood level monitoring Cyclosporine and liver transplantation:

will the midazolam test make blood level monitoring obsolete (Watkins)? 1995;22:994-6 (HEPATOLOGY Else- where

Blood volume Decreased right heart blood volume deter-

mined by magnetic resonance imaging: evidence of central underfilling in cirrhosis (M¢ller et al). 1995;22:472-8

Blunted response Blunted natriuretic response to low-dose


Bodies, apoptotic Transforming growth factor zl increases

the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes (Benedetti et al). 1995;22:1488-97

Bolus injections Effects of bolus injections and continuous

infusions of somatostatin and placebo in patients with cirrhosis: a double- blind hemodynamic investigation (Cirera et al). 1995;22:106-11

Book reviews, 1995;22:372, 1995;22:372-3, 1995;22:373, 1995;22:677, 1995;22:677-8, 1995;22:1000, 1995;22:1000-1, 1995;22:1001, 1995;22:1343, 1995;22:1343-4, 1995;22:1344, 1995;22:1616, 1995;22:1616-7, 1995;22:1617, 1995;22:1617-8, 1995;22:1891, 1995;22:1892, 1995;22:1892-3, 1995;22:1893-4, 1995;22:1894

Brain Proton spectroscopy of brain glutamine in

acute liver failure (McConnell et al). 1995;22:69-74

Brain natriuretic peptide

Blunted natriuretic response to low-dose brain natriuretic peptide infusion in nonazotemic cirrhotic patients with ascites and avid sodium retention (La Villa et al). 1995;22:1745-50

Branched-chain amino acid infusion Effects of branched-chain amino acid infu-


Brefeldin A Brefeldin A inhibits the transcytotic vesic-

ular transport of horseradish peroxidase in intrahepatic bile ductules isolated from rat liver (Benedetti et al). 1995;22:194-201

Bromosulfophthalein-glutathione Carrier-mediated uptake and excretion of

bromosulfophthalein-glutathione in perfused rat liver: a multiple indicator study (Geng et al). 1995;22:1188- 1207

Bystander effect Bystander effect caused by suicide gene

expression indicates the feasibility of gene therapy for hepatocellular carcinoma (Kuriyama et al). 1995;22:1838- 46

C

Calcium carbonate Calcium carbonate in cholesterol gall-

stones: polymorphism, distribution, and hypotheses about pathogenesis (Taylor et al). 1995;22:488-96

Cancer Integration of hepatitis B virus and alter-

ation of the lp36 region found in can- cerous tissue of primary hepatocellular carcinoma with viral replication evidenced only in noncancerous, cirrhotic tissue (Simon and Carr). 1995;22:1393-8

p53 protein immunoreactivity in extrahepatic bile duct and gallbladder cancer: correlation with tumor grade and survival (Diasmantis et al). 1995;22:774- 9

Capillaries Improved hepatocyte in vitro mainte-

nance in a culture model with woven multicompartment capillary systems: electron microscopy studies (Gerlach et al). 1995;22:546-52

Carbohydrate Serum carbohydrate-deficient trans-

ferrin; mechanism of increase after chronic alcohol intake (Xin et ai). 1995;22:1462-8

Carbon tetrachloride Carbon tetrachloride-induced hepatic in-


Vitamin E therapy of acute CC14-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding (Liu et al). 1995;22:1474-81

Cardiac plasma membrane Cardiac plasma membrane physical prop-

erties and/~-adrenergic receptor function are unaltered in portal-hypertensive rats (Ma et al). 1995;22:188-93

Cardiomyopathy Relationship between cardiomyopathy

and liver disease in chronic alcoholism (Estruch et al). 1995;22:532-8

Carrier-mediated uptake Carrier-mediated uptake and excretion of


CCAAT/enhancer binding proteins Tumor necrosis factor-alpha modulates

CCAAT/enhancer binding proteins- DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration (Diehl et al). 1995;22:252-61

CD4 ÷ Proliferative response of CD4 ÷ T cells and

hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (LShr et al). 1995;22:61-8

CD54 Differential expression and release of

CD54 induced by cytokines (Mickel- son et al). 1995;22:866-875

Cell-specific express ion Hepatoma cell-specific expression of a ret-

rovirally transferred gene is achieved by a-fetoprotein but not insulinlike growth factor II regulatory sequences (Arbuthnot et al). 1995;22:1788-96

Celiac disease Prevalence of hypertransaminasemia in

adult celiac patients and effect of gluten-free diet (Bardella et al). 1995;22:833-6

Cell cultures Cytotoxic activity ofT cells and non-T cells

from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac (Kretz- Rommel and Boelsterli). 1995;22:213- 22

Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture (Mun- tan~-Relat et al). 1995;22:1143-53

Effect of anti-ulcer drugs on DNA synthesis in adult normal human hepatocytes in culture (Blanc et al). 1995;22:814-9

Effects of extracellular matrices on tube formation of cultured rat hepatic si-


nusoidal endothelial cells (Shakado et al). 1995;22:969-73

Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture (Hillaire et al). 1995;22:82-7

Endothelin association with the cultured rat Kupffer cell: characterization and regulation (Stephenson et al). 1995;22:896-905

Feedback-inhibition of glucagon-stimu- lated glycogenolysis in hepatocyte/ Kupffer cell cocultures by glucagon- elicited prostaglandin production in Kupffer cells (Hespeling et al). 1995;22:1577-83

Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: electron microscopy studies (Gerlach et al). 1995;22:546-52

Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: characterization and expression in cultured cells (Win- wood et al). 1995;22:304-15

Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells (Gressner et al). 1995;22:1507-18

Regulation ofgene expression by interleukin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone (Roncero et al). 1995;22:1769-75

Vascular adhesion molecule-1 and intracellular adhesion molecule-1 expression on rat liver cells after lipopoly- saccharide administration in vivo (van Oosten et al). 1995;22:1538

Cell death Phenobarbital modulates the type of cell

death by rat hepatocytes during dep- rivation of serum in vitro (Chiao et al). 1995;22:297-303

Cell differentiation Coexpression of liver-specific and growth-

induced genes in perinatal and regenerating liver: attainment and maintenance of the differentiated state during rapid proliferation (Haber et al). 1995;22:906-14

A morphological study of differentiated hepatocytes in vitro (Arterburn et al). 1995;22:175-87

Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver (Golding et al). 1995;22:1243-53

The role of Kupffer cells in the differentiation process of hepatic natural killer cells (Vanderkerken et al). 1995;22:283-90

Cell proliferation Coexpression of liver-specific and growth-

induced genes in perinatal and regenerating liver: attainment and main-

tenance of the differentiated state during rapid proliferation (Haber et al). 1995;22:906-14

Flow-cytometric DNA-ploidy and proliferative activity of diethylnitrosamine- induced hepatocellular carcinoma and pulmonary metastases in mon- keys (Lapis et al). 1995;22:952-61

Proliferation-associated differences in the spatial and temporal expression of gap junction genes in rat liver (Neveu et al). 1995;22:202-12

Proliferative response of CD4 ÷ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (LiJhr et al). 1995;22:61-8

Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-l: potential role in liver injury (Marra et al). 1995;22:780-7

Cellular hydration state Metabolism of cysteinyl leukotrienes in

the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state (Wettstein et al). 1995;22:235-40

Central underfilling Decreased right heart blood volume deter-

mined by magnetic resonance imaging: evidence of central underfilling in cirrhosis (M¢ller et al). 1995;22:472-8

Cerebral blood flow Cerebral blood flow autoregnlation and


Chemoembolization Hepatic release of erythropoietin induced

by transarterial chemoembolization in patients with hepatocellular carcinoma (Pirisi et al). 1995;22:148-52

Chenodeoxycholic acid Effects of ursodeoxycholic acid and cheno-

deoxycholic acid on human hepatocytes in primary culture (Hillaire et al). 1995;22:82-7

Children Primary sclerosing cholangitis in 32 chil-

dren; clinical, laboratory, and radiographic features, with survival analysis (Wilsehanski et al). 1995;22:1415-22

Recombinant interferon-alfa therapy in children with chronic hepatitis C (Bortolotti et al). 1995;22:1623-7

Screening for hemochromatosis in children of homozygotes: prevalence and cost effectiveness (Adams et al). 1995;22:1720-7

The significance of spontaneous hepatitis B e antigen seroconversion in child- hood; with special emphasis on the clearance of hepatitis B e antigen be-

fore three years of age (change et al). 1995;22:1387-92

Chinese population An investigation of whether polymor-

phisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population (Chao et al). 1995;22:1409-14

Cholangiography Intrahepatic cholangiographic appear-

ance simulating primary sclerosing cholangitis in several hepatobiliary diseases: a postmortem cholangiographic and histopathological study in 154 livers at autopsy (Terada and Nakanuma). 1995;22:75-81

Cholangitis Intrahepatic cholangiographic appear-


Primary sclerosing cholangitis and ulcera- tive colitis; evidence for increased neoplastic potential (Broom~ et al). 1995;22:1404-8

Primary sclerosing cholangitis in 32 children; clinical, laboratory, and radiographic features, with survival analysis (Wilschanski et al). 1995;22:1415- 22

Cholecystokinin receptor gene The integrity of the cholecystokinin recep-

tor gene in gallbladder disease and obesity (Nardone et al). 1995;22:1751- 3

Cholestasis Closing in on the "familial cholestasis

gene" (Wagstaff and Jones). 1995;22:1611-13 (HEPATOLOGY Elsewhere)

Defective corticotropin-releasing hormone mediated neuroendocrine and behavioral responses in cholestatic rats; implications for cholestatic liver disease-related sickness behaviors (Swain et al). 1995;22:1560-4

Downregulation of male-specific cytochrome P450s 2Cll and 3A2 in bile duct-ligated male rats: importance to reduced hepatic content of cytochrome P450 in cholestasis (Chen et al). 1995;22:580-7

Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and medi- ates endotoxin-induced cholestasis (Whiting et al). 1995;22:1273-8

A 28-year old woman with a combined hepatic/cholestatic syndrome (Wurbs et al). 1995;22:1598-1605 (Clinicopa- thology conferences)

Cholesterol Deoxycholic acid influences cholesterol



Cholesterol crystals Mucin-vesicle interactions in model bile:


Cholesterol gallstones Calcium carbonate in cholesterol gall-


Cholesterol 7a-hydroxylase Regulation of bile acid synthesis by deoxy-

cholic acid in the rat: different effects on cholesterol 7a-hydroxylase and sterol 27-hydroxylase (Shefer et al). 1995;22:121

Cholesterol saturation Inhibition of gallbladder emptying de-

creases cholesterol saturation in bile in the Richardson ground squirrel (Pauletzki et al). 1995;22:325-31

Choline deficiency Choline deficiency; a cause of hepatic

steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation (Buchman et al. 1995;22:1399-1403

Cholitis Primary sclerosing cholangitis and ulcera-

tive colitis; evidence for increased neoplastic potential (Broom~ et al). 1995;22:1404-8

Chromosomes Integration of hepatitis B virus and alter-


Chronic effects Dynamic measurements of the acute and

chronic effects of lysosomotropic agents on hepatecyte lysosomal pH using flow cytometry (Myers et al). 1995;22:1519-26

Ciprofloxacin Ciprofloxacin and long-term prevention of

spontaneous bacterial peritonitis: re- suits of a prospective controlled trial (Relachon et al). 1995;22:1171-4

Ciprofloxacin prevents the inhibitory effects of acute ethanol exposure on hepatic regeneration in the rat (Minuk et al). 1995;22:1797-1800

Circadian locomotor activity Disruption of circadian locomotor activity


Circulation Increased production of nitric oxide by

neutrophils and monocytes from cir-

rhotic patients with ascites and hyperdynamic circulation (Laffi et al). 1995;22:1666-73

Cirrhosis, decompensated Pathogenic role of hepatitis B virus in

hepatitis B surface antigen--negative decompensated cirrhosis (Chung et al). 1995;22:25-9


Cirrhosis, experimental Role of nitric oxide and prostacyclin in the

control of renal perfusion in experimental cirrhosis (Ros et al). 1995;22:915-20

Cirrhosis, hepatic Blunted natriuretic response to low-dose

brain natrinretic peptide infusion in nonazotemic cirrhotic patients with ascites and avid sodium retention (La Villa et al). 1995;22:1745-50

Cerebral blood flow auteregulation and transcranial Doppler sonography in patients with cirrhosis (Stolze Larson et al). 1995;22:730-6

Changes in platelet kinetics after a partial splenic arterial embolization in cirrhotic patients (Noguchi et al). 1995;22:1682-8

A clinical study of lectin-reactive alpha fetoprotein as an early indicator ofhepatocellular carcinoma in the follow- up of cirrhotic patients (Shirake et al). 1995;22:802-7

Decreased right heart blood volume deter- mined by magnetic resonance imaging: evidence of central underfilling in cirrhosis (M¢ller et al). 1995;22:472-8

Does interferon therapy for chronic hepatitis B reduce the risks of developing cirrhosis and hepatocellular carcinoma (Lok). 1995;22:1336-8 (HEPA- TOLOGY Elsewhere)

Effect of upright posture and physical exercise on endogenous neurohormonal systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldosterone, and norepinephrine levels (Sal5 et al). 1995;22:479-87

Effects of bolus injections and continuous infusions of somatostatin and placebo in patients with cirrhosis: a double- blind hemodynamic investigation (Cirera et al). 1995;22:106-11

Endothelin and vascular reactivity in cirrhosis (Sieber). 1995;22:1609-11 (HEPATOLOGY Elsewhere)

Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in

aortas of cirrhotic rats (Weigert et al). 1995;22:1856-62


Inhibition of nitric oxide synthesis in the forearm arterial bed of patients with advanced cirrhosis (Campillo et al). 1995;22:1423-9

Integration of hepatitis B virus and alter- ation of the lp36 region found in can- cerous tissue of primary hepatecellular carcinoma with viral replication evidenced only in noncancerous, cirrhotic tissue (Simon and Carr). 1995;22:1393-8

Long-term effect of nadolol or nadolol plus isosorbide-5-mononitrate on renal function and ascites formation in patients with cirrhosis (Merkel et al). 1995;22:808-13

Macrophage function in cirrhosis and the risk of bacterial infection (Guarner and Runyon). 1995;22:367-8 (HEPA- TOLOGY Elsewhere)

Noninvasive 24-hour ambulatory arterial blood pressure monitoring in cirrhosis (M¢ller et al). 1995;22:88-95

Paraumbilical vein patency in cirrhosis: effects on hepatic hemodynamics evaluated by Doppler sonography (Sacerdoti et al). 1995;22:1689-94


Prognostic value of clotting and fibrino- lytic systems in a follow-up of 165 liver cirrhotic patients (Violi et al). 1995;22:96-100


Regulation of the a2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver (Inagaki et al). 1995;22:573-9

Role of defective monocyte interleukin-10 release in tumor necrosis facter-alpha overproduction in alcoholic cirrhosis (Le Moine et al). 1995;22:1436-9


Treatment of patients with cirrhosis and refractory ascites using LeVeen shunt with titanium tip: comparison with therapeutic paracentesis (Gin, se t al). 1995;22:124-31

Cirrhosis, preascitic High plasma levels of atrial natrinretic


peptide in preascitic cirrhosis: indi- rect evidence of reduced natriuretic effectiveness of the peptide (Trevisani et al). 1995;22:132-7

Clearance Proliferative response of CD4 + T cells and

hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (Lfhr et al). 1995;22:61-8


Clinical correlations Management of focal nodular hyperplasia


Clinical features Persistent hepatitis C virus infection after

liver transplantation: clinical and virological features (Gretch et al). 1995;22:1-9


Clinical significance The clinical significance of p53 gene muta-

tion in hepatocellular carcinomas from Japan (Hayashi et al). 1995;22:1702-7

Clinicopathologic correlations Hepatic involvement in mastocytesis: clin-

icopathologic correlations in 41 cases (Mican et al). 1995;22:1163-70

Clinicopathology conferences Chronic hepatitis and hepatic failure in a

14-year-old girl (Ludwig et al). 1995;22:1874-9

A 28-year old woman with a combined hepatic/cholestatic syndrome (Wurbs et al). 1995;22:1598-1605

Cloning Clonality in hepatocellular carcinoma:

analysis of methylation pattern of polymorphic X-chromosome-linked phosphoglycerate kinase gene in females (Kawai et al). 1995;22:112-7

Transport proteins and molecular biology: is cloning the beginning or the end (Stump et al)? 1995;22:669-71 (HEP- ATOLOGY Elsewhere)

Clotting Prognostic value of clotting and fibrino-

lytic systems in a follow-up of 165 liver cirrhotic patients (Violi et al). 1995;22:96-100

Coagulation factors An outbreak of hepatitis A among South

African patients with hemophilia; evidence implicating contaminated factor VIII concentrate as the source (Kedda et all). 1995;22:1363-7

Cocultures Feedback-inhibition of glucagon-stimu-

lated glycogenolysis in hepatocyte/ Kupffer cell cocultures by glucagon- elicited prostaglandin production in Kupffer cells (Hespeling et al). 1995;22:1577-83

Codon 249, human Introduction of a murine p53 mutation

corresponding to human codon 249 into a murine hepatocyte cell line re- suits in growth advantage, but not in transformation (Dumenco et al). 1995;22:1279-88

Coexpression Coexpression of liver-specific and growth-


Colchicine Synthesis of interleukin-1/~ in primary

biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression (Miller et al). 1995;22:518-24

Collagenase/gelatinase B Kupffer cell-derived 95-kd type IV colla-

genase/gelatinase B: characterization and expression in cultured cells (Win- wood et al). 1995;22:304-15

Collagen gene, a2(I) Regulation of the a2(I) collagen gene tran-

scription in fat-storing cells derived from a cirrhotic liver (Inagaki et al). 1995;22:573-9

Combined hepatic/cholestatic syndrome

A 28-year old woman with a combined hepatic]cholestatic syndrome (Wurbs et al). 1995;22:1598-1605 (Clinicopa- thology conferences)

Comparative experimental study Portal vein embolization with steel coils


Complementarity determining region 3 Limited usage of T-cell receptor/~ chains

and sequences of the complementarity determining region 3 of lymphocytes infiltrating in the liver of autoimmune hepatitis (Hoshino et al). 1995;22:142-7

Complementary DNA (cDNA) In vivo transfection of hepatitis C virus


Complications

The role of transjugular intrahepatic portosystemic shunt for treatment of portal hypertension and its complications: a conference sponsored by the national digestive diseases advisory board (Shiffman et al). 1995;22:1591- 7 (Special article)

Conference The role of transjugular intrahepatic por-

tosystemic shunt for treatment of portal hypertension and its complications: a conference sponsored by the national digestive diseases advisory board (Shiffman et al). 1995;22:1591- 7 (Special article)

Confluent monolayers Toyota T. Confluent monolayers of bile

duct epithelial cells with tight junctions (Okamoto et al). 1995;22:153-9

Conformational epitope Autoantibodies to BCOADC-E2 in pa-


Congenital defects Impaired biliary excretion and whole body


Conjugates Specific targeting of adriamycin conju-


Continuous infusions Effects of bolus injections and continuous


Contractile response, hepatic sinusoidal

Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat (Bauer et al). 1995;22:1565-76

Copper In vitro modeling of liver membrane cop-

per transports (Schilsky). 1995;22:1340-2 (HEPATOLOGY Elsewhere)

Cord blood, human The influence of a maternal chronic hepa-


Core antigen Immunoglobulin M antibody to hepatitis

C virus core antigen: correlations with viral replication, histological activity, and liver disease outcome (Quiroga et al). 1995;22:1635-40


Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus (Marinos et al). 1995;22:1040-9

Core gene mutations Hepatitis B virus infection: precore mu-

tants and its relation to viral geno- types and core mutations (Rodriguez- Frias et al). 1995;22:1641-7

Naturally occurring hepatitis B virus core gene mutations (Akarca and Lok). 1995;22:50-60

Core protein Interferon gamma production by periph-

eral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection (Iwata et al). 1995;22:1057-64

The significance ofimmunoglobulin M antibody response to hepatitis C virus core protein in patients with chronic hepatitis C (Yukim et al). 1995;22:402-6

Core variation Hepatitis B virus precore/core variation

and interferon therapy (Fattovich et al). 1995;22:1355-62

Corrections, 1995;22:1019, 1995;22:1898 Correspondence

Acetylcholine-induced vasorelaxation in portal hypertensive rats (Michielsen et al) (Letter); (Jim~nez) (Reply). 1995;22:1009-11

Alveolar echinococcosis (Mosimann et al) (Letter); (Ammann) (Reply). 1995;22:1007-9

Aplastic anemia after liver transplantation (Collins and Klintmalm) (Letter); (Cattral and Langnas) (Reply). 1995;22:1011-12

Creatine kinase BB: markedly increased in fulminant hepatic failure caused by massively disseminated lymphoma cells in the liver (Sugano and Suzuki) (Letter); (Vaubourdolle et al) (Reply). 1995;22:679-80

Gastric mucosal hemodynamics in portal- hypertensive gastropathy: the debate goes on (Guslandi and TittobeUo) (Letter); (Ohta et al) (Reply). 1995;22:1002-4

In defense of the arterial ketone body ratio (Saibara) (Letter); (Kawasaki) (Re- ply). 1995;22:1004-7

Retraction (Van Thiel) (Letter), 1995;21:1619

Ursodeoxycholic acid for chronic hepatitis C patients (Puoti et al) (Letter). 1995;22:1002

Corticotropin-releasing hormone Defective corticotropin-releasing hormone

mediated neuroendocrine and behavioral responses in cholestatic rats; implications for cholestatic liver dis-

ease-related sickness behaviors (Swain et al). 1995;22:1560-4

Cost effectiveness Screening for hemochromatesis in chil-

dren of homozygotes: prevalence and cost effectiveness (Adams et al). 1995;22:1720-7

Couplets Transport characteristics of three fluores-

cent conjugated bile acid analogs in isolated rat hepatocytes and couplets (Maglova et al). 1995;22:637-47

Creatine kinase BB Creatine kinase BB: markedly increased

in fulminant hepatic failure caused by massively disseminated lymphoma cells in the liver (Sugano and Suzuki) (Letter); (Vaubourdolle et al) (Reply). 1995;22:679-80

Crigler-Najjar syndromes The physiology of jaundice: molecular and

functional characterization of the Crigler-Najjar syndromes (Berg). 1995;22:1338-40 (HEPATOLOGY Elsewhere)

Cyclosporine Cyclosporine and liver transplantation:


Renal effects of dietary supplementation with fish oil in cyclosporine-treated liver transplant recipients (Badala- menti et al). 1995;22:1695-1701

CYP1A1 Differential effects of cytokines on the in-

ducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture (Mun- tan~-Relat et al). 1995;22:1143-53

CYPIA2 Differential effects of cytokines on the in-


CYP3A4 Differential effects of cytokines on the in-


Cysteinyl leukotrienes Metabolism of cysteinyl leukotrienes in


Cytochrome P402E1 polymorphisms An investigation of whether polymor-

phisms of cytochreme P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population (Chao et al). 1995;22:1409-14

Cytochrome P450s 2Cll and 3A2 Downregulation of male-specific cyto-

chrome P450s 2Cl l and 3A2 in bile duct-ligated male rats: importance to reduced hepatic content of cytochrome P450 in cholestasis (Chen et al). 1995;22:580-7

Cytokines Cytokine gene expression by Kupffer cells

in experimental alcoholic liver disease (Kamimura and Tsukarnoto). 1995;22:1304-9

Differential effects of cytokines on the inducible expression of CYPIA1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture (Mun- tand-Relat et al). 1995;22:1143-53

Differential expression and release of CD54 induced by cytokines (Mickel- son et al). 1995;22:866-875

Cytoplasmic enzymes The effect ofprostaglandin E1 on liver ade-


Cytotoxicity Cytotoxic activity ofT cells and non-T cells


D

Deconjugation resistance N-Ethyl-tauroursodeoxycholic acid, a


Deficiencies Choline deficiency; a cause of hepatic


The liver in adolescents with al-antitrypsin deficiency (Sveger and Eriksson). 1995;22:514-7

Peroxisome mosaicism in the livers of per- oxisomal deficiency patients (Espeel et al). 1995;22:497-504

Serum carbohydrate-deficient transferrin; mechanism of increase after chronic alcohol intake (Xin et al). 1995;22:1462-8

DeoxychoHc acid Deoxycholic acid influences cholesterol


Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7a-hydroxylase and


sterol 27-hydroxylase (Shefer et al). 1995;22:121

Dexamethasone Regulation of gene expression by interleu-

kin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone (Roncero et al). 1995;22:1769-75

Diclofenac Cytotoxic activity ofT cells and non-T cells


Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the Food and Drug Administration as adverse reactions (Banks et al). 1995;22:820-7

Diet Renal effects of dietary supplementation

with fish oil in cyclosporine-treated liver transplant recipients (Badala- menti et al). 1995;22:1695-1701

A fish oil diet minimizes hepatic reperfusion injury in the low-flow, reflow liver perfusion model (Zhong and Thurman). 1995;22:929-35

Prevalence of hypertransaminasemia in adult celiac patients and effect of gluten-free diet (Bardella et al). 1995;22:833-6

Diethyinitrosamine Flow-cytometric DNA-ploidy and prolifer-

ative activity of diethylnitrosamine- induced hepatocellular carcinoma and pulmonary metastases in mon- keys (Lapis et al). 1995;22:952-61

Differential activation Differential activation of transcription


Differential display Differential display and integrin alpha 6

messenger RNA overexpression in hepatocellular carcinoma (Begum et al). 1995;22:1447-55

Differential effects Differential effects of cytokines on the in-


The differential effects of three forms of interferon alfa on hepatic regeneration after partial hepatectomy in the rat (Wong et al). 1995;22:883-6

Differential expression Differential expression and release of

CD54 induced by cytokines (Mickel- son et al). 1995;22:866-875

Differential expression of A and B laminin chains during rat liver regeneration (Gim~nez et al). 1995;22:1259-62

Disease progression Serum concentration of intercellular ad-

hesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis (Shimizu et al). 1995;22:525-31

Synthesis of interleukin-lB in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression (Miller et al). 1995;22:518-24

Disruption Disruption of circadian locomotor activity


Distal tubules Reversal of atrial natriuretie peptide re-

sistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis (Abraham et al). 1995;22:737-43

Distinct pathways Interleukin-1 and nitric oxide protect

against tumor necrosis factor-a-induced liver injury through distinct pathways (Bohlinger et al). 1995;22:1829-37

Distribution Calcium carbonate in cholesterol gall-


Subcellular distribution of large and small hepatitis delta antigen in hepatocytes of hepatitis delta virus superinfected woodchucks (Cullen et al). 1995;22:1090-1100

Diuresis Systemic hypertension and diuresis by L-


Diversity Diversity of quasispecies in various dis-

ease stages of chronic hepatitis C virus infection and its significance in interferon treatment (Koizumi et al). 1995;22:30-5

DNA b ind ing activities Tumor necrosis factor-alpha modulates


DNA hypomethylat ion, global Carbon tetrachloride-induced hepatic in-


DNA-ploidy Flow-cytometric DNA-ploidy and prolifer-

ative activity of diethylnitrosamine-

induced hepatocellular carcinoma and pulmonary metastases in mon- keys (Lapis et al). 1995;22:952-61

DNA synthesis Effect of anti-ulcer drugs on DNA synthe-


Donor age Effect of donor age and sex on the outcome


Donor screening Efficacy of screening donors for antibodies

to the hepatitis C virus to prevent transfusion-associated hepatitis: fi- nal report of a prospective trial (Gon- z~lez et al). 1995;22:439-45

Donor selection l imits Donor selection limits use of living-related

liver transplantation (Renz et al). 1995;22:1122-6

Donor sex Effect of donor age and sex on the outcome


Doppler sonography Paraumbilical vein patency in cirrhosis:

effects on hepatic hemodynamics evaluated by Doppler sonegraphy (Sacerdoti et al). 1995;22:1689-94

Doppler sonography, transcranial Cerebral blood flow autoregulatien and


Double-blind hemodynamic investigation


Double-blind randomized placebo-controlled t r ial

A randomized double-blind, placebo-controlled trial of ursodeosycholic acid in primary biliary cirrhosis (Combes et al). 1995;22:759-66

Downregulation Downregulation of male-specific cyto-

chrome P450s 2Cll and 3A2 in bile duct-ligated male rats: importance to reduced hepatic content of cytochrome P450 in cholestasis (Chen et al). 1995;22:580-7

Downregulation of phorbot 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-l~ production and gene expression in human monocytic cells by human alpha- fetoprotein (Wang and Alpert). 1995;22:921-8

Dual hepat i t is virus infection Role of hepatitis C virus in dual and triple


hepatitis virus infection (Liaw). 1995;22:1101-8

Dynamic measurements Dynamic measurements of the acute and


E

E2 component Hepatic distribution of E2 component of

pyruvate dehydrogenase complex after transplantation (Neuberger et al). 1995;22:798-801

E2 glycoprotein Humoral response to linear B cell epitepes


Economic appraisal Treatment of chronic type B and C hepati-

tis with interferon alfa: an economic appraisal (Dusheiko and Roberts). 1995;22:1863-73 (Special article)

Economic modeling Economic modeling of treatment in

chronic hepatitis B and chronic hepatitis C: promises and limitations (Koff and Seeff). 1995;22:1880-2

Editorials Does interferon precipitate rejection of

liver allografts (Min and Boden- heimer)? 1995;22:1333-5

Economic modeling of treatment in chronic hepatitis B and chronic hepatitis C: promises and limitations (Koff and Seeff. 1995;22:1880-2

Endoscopic treatment of choice for patients with bleeding esophageal varices (Laine)? 1995;22:663-5

Fatigue associated with chronic liver disease: a riddle wrapped in a mystery inside an enigraa (Jones). 1995;22:1606-8

Hepatocellular carcinomas associated with hepatitis B and C virus infec- tions: are they any different (Okuda)? 1995;22:1883-4

Immune mechanisms of alcohol-induced liver disease (Klassen et al). 1995;22:355-7

Liver transplantation for hepatitis C: the promise and the challenge (Di Bisceg- lie). 1995;22:660-2

p53 proteins and aflatoxin BI: the good, the bad, and the ugly (Liang). 1995;22:1330-2

Predictors of a sustained beneficial response to interferon alfa therapy in chronic hepatitis C (Conjeevaram et al). 1995;22:1326-9

Wherefore art thou liver disease associ-

ated with alpha-1 antitrypsin deficiency (Sharp)? 1995;22:666-8

Electron microscopy Improved hepatocyte in vitro mainte-

nance in a culture model with woven multicompartment capillary systems: electron microscopy studies (Gerlaeh et al). 1995;22:546-52

Embolization Changes in platelet kinetics after a partial

splenic arterial embolization in cirrhotic patients (Noguehi et al). 1995;22:1682-8

Portal vein embolization with steel coils and absolute ethanol:a comparative experimental study with canine liver (Yamakado et al). 1995;22:1812-8

Encephalopathy, hepatic Advances in hepatic encephalopathy and

metabolic nitrogen exchange (Blei). 1995;22:1891 (Book review)

Portal-systemic shunting and portal-systemic encephalopathy: a predictable relationship (Conn). 1995;22:365-6 (HEPATOLOGY Elsewhere)

Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat (Oppong et al). 1995;22:553-8

Endoplasmic reticulum (ER) Processing of endoplasmic reticulum lu-

minal antigens associated with halothane hepatitis in rat hepatocytes (Amouzadeh and Pohl). 1995;22:936- 43

Endoscopic retrograde cholangiopancreatography

Text and atlas of endoscopic retrograde cholangiopanereatography (Marcel). 1995;22:677-8 (Book review)

Endoscopy Endoscopic treatment of choice for pa-

tients with bleeding esophageal varices (Laine)? 1995;22:663-5 (Editorial)

Endothelial cells, hepatic Effects of extracellular matrices on tube

formation of cultured rat hepatic sinusoidal endothelial cells (Shakado et al). 1995;22:969-73

Fc receptors in liver sinusoidal endothelial cells in NZBAV F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2) (Ahmed et al). 1995;22:316-24

Hepatic sinusoidal endothelial cells can store and metabolized serum immunoglobulin (Iwamura et al). 1995;22:1456-61

Mouse hepatitis virus type 3 infection pro- vokes a decrease in the number of sinusoidal endothelial cell fenestrae both in vivo and in vitro (Steffan et al). 1995;22:395-401

Endothelin Endothelin and vascular reactivity in cir-

rhosis (Sieber). 1995;22:1609-11 (HEPATOLOGY Elsewhere)


Endothelin-1 Chronic ethanol consumption increases

hepatic sinusoidal contractile response to endothelin-1 in the rat (Bauer et al). 1995;22:1565-76

Endotoxemia, acute Hepatic nitric oxide production following

acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression (Laskin et al).

Endotoxin Endotoxin and interleukin-1 related he-

patic inflammatory response promotes liver failure after partial hepatectomy. 1995;22:1499-1506"

Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state (Wettstein et al). 1995;22:235-40

Nitric oxide donor prevents hepatic and systemic perfusion decrease induced by endotoxin in anesthetized rabbits (Pastor et al). 1995;22:1547-53


End-stage organ damage An investigation of whether polymor-

phisms of cytochrome P4502EI are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population (Chao et al). 1995;22:1409-14

Enhancer binding proteins Tumor necrosis factor-alpha modulates


Envelope glycoprotein Humoral response to linear B cell epitopes


Enzymes The effect of prostaglandin E1 on liver ade-


Hepatitis C viral quasispecies in hepatitis C virus carriers with normal liver enzymes and patients with type C

HEPATOLOGY Vo1. 22, No. 6, 1995 SUBJECT INDEX 1929

chronic liver disease (Naito et al). 1995;22:407-12


Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes (Nakano et al). 1995;22:262-6

Epidermal growth factor (EGF) Intracellular pH regulation in Hep G2

cells: effects of epidermal growth factor, transforming growth factor-a, and insulinlike growth factor-II on Na+/H ÷ exchange activity (Strazza- bosco et al). 1995;22:588-97

Regulation ofgene expression by interleukin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone (Roncero et al). 1995;22:1769-75

Role ofheparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy (Kiso et al). 1995;22:1584-90

Epithelial cells, bile duct Confluent monolayers of bile duct epithe-

lial cells with tight junctions (Oka- moto et al). 1995;22:153-9

Epithelial cells, b i l iary Abnormal expression of PDC-E2 on the

apical surface of biliary epithelial cells in patients with antimitechon- drial antibody-negative primary biliary cirrhosis (Tsuyenama et al). 1995;22:1440-6

Epitopes Autoantibodies to BCOADC-E2 in pa-

tients with primary biliary cirrhosis recognize a conformational epitepe (Leung et al). 1995;22:505-13

Humoral response to linear B cell epitopes in the amino terminus of the hepatitis C virus envelope glycoprotein gp72 (E2): Role in protective immunity still unknown (Weiner). 1995;22:369-71 (HEPATOLOGY Elsewhere)

Erythropoietin Hepatic release of erythropoietin induced

by transarterial chemoembolization in patients with hepatecellular carcinoma (Pirisi et al). 1995;22:148-52


Escherichia coli Proteolytic activity ofNS3 serine protein-

ase of hepatitis C virus efficiently ex- pressed in Escherichia coli (Shoji et al). 1995;22:1648-55

Esophageal varices, bleeding Endoscopic treatment of choice for pa-

tients with bleeding esophageal varices (Laine)? 1995;22:663-5 (Editorial)

A prospective, randomized trial of sclerotherapy versus ligation in the management of bleeding esophageal vari- cos (Lo et al). 1995;22:466-71

Estradiol Parenchymal and nonparenchymal up-

take of technetium-99m, indium-i l l , and iodine-125 low-density lipopre- tein in the normal and estradiol-stim- ulated rat liver: tracer validation for quantitative low-density lipoprotein scintlgraphy (Leitha et al). 1995;22:1289-95

Ethanol consumption, chronic Chronic ethanol consumption increases

hepatic sinnsoidal contractile response to endothelin-1 in the rat (Bauer et al). 1995;22:1565-76


Portal vein embolization with steel coils and absolute ethanoha comparative experimental study with canine liver (Yamakado et al). 1995;22:1812-8

N-Ethyl.tauroursodeoxycholic acid N-Ethyl-tauroursodeoxycholic acid, a


Excretion Carrier-mediated uptake and excretion of

bremosulfophthalein-glutathione in perfused rat liver: a multiple indicator study (Geng et al). 1995;22:1188- 1207

Excretion of F2-isoprostanes in bile: a novel index of hepatic lipid peroxidation (Awad and Morrow). 1995;22:962-8

Extracel lular matr ices Effects of extracellular matrices on tube

formation of cultured rat hepatic sinusoidal endothelial ceils (Shakado et al). 1995;22:969-73

Extrahepatic bile duct cancer p53 protein immunoreactivity in extrahe-


F

F2-isoprostanes Excretion of F2-isoprostanes in bile: a

novel index of hepatic lipid perexidation (Awad and Morrow). 1995;22:962-8

Famil ial prevalence High familial prevalence of gallstones in

the first-degree relatives of gallstone patients (Sarin et al). 1995;22:138-41

Fat-s tor ing cells Regulation of the ~2(I) collagen gene tran-

scription in fat-storing cells derived from a cirrhotic liver (Inagaki et al). 1995;22:573-9

Thromhin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-l: potential role in liver injury (Marra et al). 1995;22:780-7

Fc receptors Fc receptors in liver sinnsoidal endothe-

lial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2) (Ahmed et al).

Factor VIII concentrate, contaminated An outbreak of hepatitis A among South

African patients with hemophilia; evidence implicating contaminated facter VIII concentrate as the source (Kedda et all). 1995;22:1363-7

Fnmillal cholestasis gene Closing in on the "familial cholestasis

gene" (Wagstaff and Jones). 1995;22:1611-13 (HEPATOLOGY Elsewhere)

Fasting, donor Inactivation of Kupffer cells after pro-

longed donor fasting improves viabil- ity of transplanted hepatic ailografts (Sankary et al). 1995;22:1236-42

Fat igue Fatigue associated with chronic liver dis-

ease: a riddle wrapped in a mystery inside an enigma (Jones). 1995;22:1606-8 (Editorial)

Feedback inhibition Feedback-inhibition of glucagon-stimu-


Females Clonality in hepatocellular carcinoma:


Fenestrae Mouse hepatitis virus type 3 infection pro-

vokes a decrease in the number of sinnsoidal endothelial cell fenestrae both in vivo and in vitro (Steffan et al). 1995;22:395-401

Fibrogenesis Sequential acetaldehyde production, lipid

perexidation, and fibrogenesis in micropig model of alcohol-induced liver disease (Niemel~t et al). 1995;22:1208- 14

Fibr inolyt ic systems Prognostic value of clotting and fibrino-

lytic systems in a follow-up of 165


liver cirrhotic patients (Violi et al). 1995;22:96-100

Fibrogenic cells, hepatic Human myofibroblastlike cells obtained

by outgrowth are representative of the fibrogenic cells in the liver (Bla- zejewski et al). 1995;22:788-97

First-degree relatives High familial prevalence of gallstones in


Fish oil diet A fish oil diet minimizes hepatic reperfu-

sion injury in the low-flow, reflow liver perfusion model (Zhong and Thurman). 1995;22:929-35


Flow cytometry Dynamic measurements of the acute and



Focal nodular hyperplasia Management of focal nodular hyperplasia

and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correla.tions (Cherqui et al). 1995;22:1674-81

Follow-up study The natural history of nonalcoholic fatty

liver: a follow-up study (Tell et al). 1995;22:1714-9

Food and Drug Administration (FDA) Diclofenac-associated hepatotoxicity:


Forearm Inhibition of nitric oxide synthesis in the


Fulminant hepatic failure Creatine kinase BB: markedly increased


Detection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failure (Villamil et al). 1995;22:1379-86

Fulminant hepatitis associated with hepatitis B virus e antigen-negative in-

fection: importance of host factors (Karayiannis et al). 1995;22:1628-34

Parvovirus B19 as a possible causative agent of fulminant liver failure and associated aplastic anemia (Langnas et al). 1995;22:1661-5

Functional characterizat ion The physiology of jaundice: molecular and


Fusion, vesic le Mucin-vesicle interactions in model bile:


G

Galactose-specific receptor Independent modulation of galactose-spe-

ciflc receptor expression in rat liver cells (Massimi et al). 1995;22:1819-28

Gallbladder bile Deoxycholic acid influences cholesterol


Gallbladder cancer p53 protein immunoreactivity in extrahe-


Gallbladder disease The integrity of the cholecystokinin recep-


Gallbladder emptying Inhibition of gallbladder emptying de-

creases cholesterol saturation in bile in the Richardson ground squirrel (Pauletzki et al). 1995;22:325-31

Gallstones High familial prevalence of gallstones in


Ganciclovir Induction of sensitivity to ganciclovir in

human hepatoeellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase (Qian et al). 1995;22:118-23

Gap junct ion genes Proliferation-associated differences in the

spatial and temporal expression of gap junction genes in rat liver (Neveu et al). 1995;22:202-12

Gastric mucosa Gastric mucosal hemodynamics in portal-

hypertensive gastropathy: the debate goes on (Guslandi and Tittobello) (Letter); (Ohta et al) (Reply). 1995;22:1002-4

Gastroenterology Bockus gastroenterology. Ed 5 (Koff).

1995;22:1343-4 (Book review) Gastropathy

Gastric mucosal hemodynamics in portal- hypertensive gastropathy: the debate goes on (Guslandi and Tittobetlo) (Letter); (Ohta et al) (Reply). 1995;22:1002-4

Gelatinase B Kupffer cell-derived 95-kd type IV colla-

genase/gelatinase B: characterization and expression in cultured cells (Win- wood et al). 1995;22:304-15

Gender Disruption of circadian locomotor activity


Effect of donor age and sex on the outcome of liver transplantation (Marino et al). 1754-62

Gene delivery In vivo transfection of hepatitis C virus


Gene express ion Cytokine gene expression by Kupffer cells


Downregulation of phorbol 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-lfl production and gene expression in human monocytic cells by human alpha- fetoprotein (Wang and Alpert). 1995;22:921-8

Elevated mitochondrial gene expression during rat liver regeneration after portal vein ligation (Shimizu et al). 1995;22:1222-9

Gene expression of N-acetylglucosaminyltransferases III and IV: a possible im- plication for liver regeneration (Mi- yoshi et al). 1995;22:1847-55

The growth inhibitory effects of vitamins K and their actions on gene expression (Wang et al). 1995;22:876-82

Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone (Roncero et al). 1995;22:1769-75

Tumor necrosis factor-alpha modulates CCAAT/enhancer binding proteins- DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration (Diehl et al). 1995;22:252-61

Genes Can a guest liver bring the gift of a gene

to disarm a hostile host (Guha and


Chowdhury)? 1995;22:1888-90 (HEP- ATOLOGY Elsewhere)

Clonality in hepatocellular carcinoma: analysis of methylation pattern of polymorphic X-chromosome-linked phosphoglycerate kinase gene in females (Kawai et al). 1995;22:112-7

Closing in on the "familial cholestasis gene" (Wagstaff and Jones). 1995;22:1611-13 (HEPATOLOGY Elsewhere)

Coexpression of liver-specific and growth- induced genes in perinatal and regenerating liver: attainment and maintenance of the differentiated state during rapid proliferation (Haber et al). 1995;22:906-14

Hepatic nitric oxide production following acute endotexemia in rats is mediated by increased inducible nitric oxide synthase gene expression (Laskin et al).

Hepatitis B virus precore/core variation and interferon therapy (Fattovich et al). 1995;22:1355-62

Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by a-fetoprotein but not insulinlike growth factor II regulatory sequences (Arbuthnot et al). 1995;22:1788-96

The influence of a maternal chronic hepatitis B virus infection on the repertoire of transcribed T-cell receptor beta chain variable region genes in human cord blood (Abbott et al). 1995;22:1034-9

The integrity of the cholecystokinin receptor gene in gallbladder disease and obesity (Nardone et al). 1995;22:1751- 3

Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation (Dumenco et al). 1995;22:1279-88

Naturally occurring hepatitis B virus core gene mutations (Akarca and Lok. 1995;22:50-60

Nuclear scaffold-associated protease: in situ nuclear localization and effects of a protease inhibitor on growth and morphology of a ras-transformed hepatocyte cell line (Clawson et al). 1995;22:1230-5



Regulation of the a2(I) collagen gene transcription in fat-storing cells derived

from a cirrhotic liver (Inagaki et al). 1995;22:573-9

Specific inhibition of hepatitis C viral gene expression by antisense phosphorothioate oligodeoxynucleotides (Alt et al). 1995;22:707-17

Genetic hemochromatosis Portal hypertension and iron depletion in

patients with genetic hemochromatosis (Fraeanzani et al). 1995;22:1127- 31

Genetic markers An investigation of whether polymor-

phisms of eytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population (Chao et al). 1995;22:1409-14

Gene therapy Bystander effect caused by suicide gene


Gene transfer Induction of sensitivity to ganciclovir in

human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase (Qian et al). 1995;22:118-23

Rapid and efficient gene transfer in human hepatocytes by herpes viral factors (Fong et al). 1995;22:723-9

Genotype Hepatitis B virus infection: preeore mu-

tants and its relation to viral geno- types and core mutations (Rodrignez- Frias et al). 1995;22:1641-7

Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C (Martinot-Peig- noux et al). 1995;22:1050-6

Glucagon Feedback-inhibition of glucagon-stimu-


Metabolic effect of sodium selenite: insu- lin-like inhibition of giucagon-stimu- lated glycogenolysis in the isolated perfused rat liver (Roden et al). 1995;22:169-74

Glutamate Synaptosomal glutamate transport in

thioacetamide-indueed hepatic encephalopathy in the rat (Oppong et al). 1995;22:553-8

Glutamine Proton spectroscopy of brain glutamine in


Glutathione Carrier-mediated uptake and excretion of


Impaired biliary excretion and whole body elimination of methylmercury in rats with a congenital defect in biliary glutathione excretion (Ballateri et al). 1995;22:1469-73

Gluten-free diet Prevalence of hypertransaminasemia in


Glycoconjugates Expression of glycoconjugates during in-

trahepatic bile duct development in the rat: an immunohistochemical and lectin-histochemica] study (Sanzen et al). 1995;22:944-51

Glycogenolysis Feedback-inhibition of glucagon-stimu-


Metabolic effect of sodium selenite: insu- lin-like inhibition of glucagon-stimu- lated glycogenolysis in the isolated perfused rat liver (Roden et al). 1995;22:169-74

Glycoproteins Humoral response to linear B cell epitopes


gp72 glycoprotein Humoral response to linear B cell epitopes


Graph design Elements of Graph Design (Koff).

1995;22:372-3 (Book review) Growth advantage


H

Halothane hepatitis Processing of endoplasmic reticulum lu-

minal antigens associated with halo-


thane hepatitis in rat hepatocytes (Amouzadeh and Pohl). 1995;22:936- 43

HBeAG Fulminant hepatitis associated with hep-

atitis B virus e antigen-negative infection: importance of host factors (Karayiannis et al). 1995;22:1628-34

HBsAG Pathogenic role of hepatitis B virus in

hepatitis B surface antigen--negative decompensated cirrhosis (Chung et al). 1995;22:25-9


HDAg Subcellular distribution of large and small

hepatitis delta antigen in hepatocytes of hepatitis delta virus superinfected woodchucks (Cullen et al). 1995;22:1090-1100

Hemochromatos is Iron-responsive element-binding protein

in hemochromatosis liver and intes- tine (Flanagan et al). 1995;22:828-32

Portal hypertension and iron depletion in patients with genetic hemochromatosis (Fracanzani et al). 1995;22:1127- 31


Hemodynamics Beneficial effects of intravenous albumin

infusion on the hemodynamic and humoral changes after total paracentesis (Luca et al). 1995;22:753-8


Gastric mucosal hemodynamics in portal- hypertensive gastropathy: the debate goes on (Guslandi and Tittobello) (Letter); (Ohta et al) (Reply). 1995;22:1002-4

Hemodynamics after orthotopic liver transplantation: study of associated factors and long-term effects (Gadano et al). 1995;22:458-65

Paraumbilical vein patency in cirrhosis: effects on hepatic hemodynamics evaluated by Doppler sonography (Sacerdoti et al). 1995;22:1689~94

Hemophil ia An outbreak of hepatitis A among South

African patients with hemophilia; evidence implicating contaminated factor VIII concentrate as the source (Kedda et al). 1995;22:1363-7

Heparin-binding epidermal growth factor-like growth factor

Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy (Kiso et al). 1995;22:1584-90

Hepatitis, chronic Chronic hepatitis and hepatic failure in a


Hepatit is A virus (HAV) An outbreak of hepatitis A among South

African patients with hemophilia; evidence implicating contaminated factor VIII concentrate as the source (Kedda et all). 1995;22:1363-7

Hepatit is B e-minus hepatit is B virus mutants

Proliferative response of CD4 + T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (LShr et al). 1995;22:61-8

Hepatit is B virus (I-IBV) Anti-hepatitis B virus activity of a mix-

ture of two monoclonal antibodies in an "inhibition in solution" assay (Heijtink et al). 1995;22:1078-83

Characteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in Japan (Shiratori et al). 1995;22:1027-33

A comparison of the surgical results in patients with hepatitis B virus versus hepatitis C-related hepatocellular carcinoma (Takenaka et al). 1995;22: 20-4


Economic modeling of treatment in chronic hepatitis B and chronic hepatitis C: promises and limitations (Koff and Seeff. 1995;22:1880-2 (Editorial)

Effect of immunosuppressive and antiviral agents on hepatitis B replication in vitro (McMillan et al). 1995;22:36- 43

Expression of transforming growth factor alpha in the liver before and after interferon alfa therapy for chronic hepatitis B (Morimitsu et al). 1995;22:1021-6

Hepatitis B virus infection in high-risk inner-city neighborhoods in San Fran- cisco (Siegel et al). 1995;22:44-9

Hepatitis B virus infection: preeore mutants and its relation to viral geno- types and core mutations (Rodriguez- Frias et al). 1995;22:1641-7

Hepatocellular carcinomas associated with hepatitis B and C virus infec-

tions: are they any different (Okuda)? 1995;22:1883-4 (Editorial)

Induction ofT-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus (Marinos et al). 1995;22:1040-9


In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin-2 production: implications for modeling immunity and therapy in hepatitis B virus infection (Cote and Gerin). 1995;22:687-99

In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA (Rosmorduc et al). 1995;22:10-19


Hepatitis B virus transgenic mice: in- sights into the virus and the disease (Chisari). 1995;22:1316-25 (Special article)


Pathogenic role of hepatitis B virus in hepatitis B surface antigen--negative decompensated cirrhosis (Chung et al). 1995;22:25-9

Proliferative response of CD4 ÷ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (L~hr et al). 1995;22:61-8

Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North Ameri- can urban population (Sherman et al). 1995;22:432-8

Treatment of chronic type B and C hepatitis with interferon alfa: an economic appraisal (Dusheiko and Roberts). 1995;22:1863-73 (Special article)

Hepatit is B e-minus hepatit is B virus mutants

Proliferative response of CD4 ÷ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (L~hr et al). 1995;22:61-8

Hepatit is C virus (HCV)


Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C (Coverdale et al). 1995;22:1065-71

Characteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in Japan (Shiratori et al). 1995;22:1027-33

A comparison of the surgical results in patients with hepatitis B virus versus hepatitis C-related hepatocelhilar carcinoma (Takenaka et al). 1995;22: 20-4


Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment (Koizumi et al). 1995;22:30-5

Does the healthy hepatitis C virus carrier state really exist? An analysis using polymerase chain reaction (Prieto et al). 1995;22:413-7

Economic modeling of treatment in chronic hepatitis B and chronic hepatitis C: promises and limitations (Koff and Seeff. 1995;22:1880-2 (Editorial)


Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level (Yamada et al). 1995;22:1351-4

Efficacy of screening donors for antibodies to the hepatitis C virus to prevent transfusion-associated hepatitis: fi- nal report of a prospective trial (Gon- zalez et al). 1995;22:439-45

Focal lymphocytic aggregates in chronic hepatitis C: occurence, immunohistochemical characterization, and relation to markers of autoimmunity (Freni et al). 1995;22:389-94

Hepatitis C: IIb (IV) or not IIb (IV) that is the question (Sallie). 1995;22:671- 4 (HEPATOLOGY Elsewhere)

Hepatitis C viral quasispecies in hepatitis C virus carriers with normal liver enzymes and patients with type C chronic liver disease (Naito et al). 1995;22:407-12

Hepatitis C virus (Davis). 1995;22:1343 (Book review)

Hepatocellular carcinoma complicating autoimmune hepatitis: role of hepatitis C virus (Ryder et al). 1995;22:718- 22

Hepatocellular carcinomas associated with hepatitis B and C virus infec- tions: are they any different (Okuda)? 1995;22:1883-4 (Editorial)

Humoral response to linear B cell epitopes in the amino terminus of the hepatitis C virus envelope glycoprotein gp72 (E2): Role in protective immunity still unknown (Weiner). 1995;22:369-71 (HEPATOLOGY Elsewhere)


Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection (Iwata et al). 1995;22:1057-64

In vivo transfection of hepatitis C virus complementary DNA into rodent liver by asialoglycoprotein receptor mediated gene delivery (Yamamoto et al). 1995;22:847-5

Liver transplantation for hepatitis C: the promise and the challenge (Di Bisceg- lie). 1995;22:660-2 (Editorial)

Long-term decrease in serum N-terminal propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alfa (Suou et al). 1995;22:426-31

Naturally occurring hepatitis B virus core gene mutations (Akarca and Lok). 1995;22:50-60

An open trial of interferon alfa recombinant for hepatitis C after liver transplantation: antiviral effects and risk of rejection (Fdray et al). 1995;22:1084-9

Persistent hepatitis C virus infection after liver transplantation: clinical and virological features (Gretch et al). 1995;22:1-9

Predictors of a sustained beneficial response to interferon alfa therapy in chronic hepatitis C (Conjeevaram et al). 1995;22:1326-9 (Editorial)


Proteolytic activity of NS3 serine proteinase of hepatitis C virus efficiently ex- pressed in Escherichia coli (Shoji et al). 1995;22:1648-55

Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C (Chemello et al). 1995;22:700-6

Recombinant interferon-alfa therapy in children with chronic hepatitis C (Bortolotti et al). 1995;22:1623-7

Role of hepatitis C virus in dual and triple hepatitis virus infection (Liaw). 1995;22:1101-8


The significance of immunoglobulin M antibody response to hepatitis C virus core protein in patients with chronic hepatitis C (Yukim et al). 1995;22:402-6


T-cell-mediated autologous hepatotoxicity in patients with chronic hepatitis C virus infection (Liaw et al). 1995;22:1368-73



The virological and histological states of anti-hepatitis C virus-positive sub- jects with normal liver biochemical values (Shindo et al). 1995;22:418-25

Utility of hepatitis C virus RNA determi- nations in hepatic tissue as an end point for interferon treatment of chronic hepatitis C (Gurakar et al). 1995;22:1109-12

Hepatitis delta virus (HDV) Evidence of transmission of hepatitis D

virus to spouses from sequence analysis of the viral genome (Wu et al). 1995;22:1656-60



Hepatobiliary diseases Intrahepatic cholangiographic appear-


Hepatobiliary malignancy Hepatobiliary malignancy: its multidisci-

plinary management (Meyers). 1995;22:1000 (Book review)

Hepatobiliary transport Hepatobiliary transport of hepatic 3-hy-

droxy-3-methylglutaryl coenzyme A


reductase inhibitors conjugated with bile acids (Petzinger et al). 1995;22:1801-11

Hepatocellular adenoma Management of focal nodular hyperplasia


Hepatocellular carcinoma (HCC) Bystander effect caused by suicide gene


Characteristic difference ofhepatocellular carcinoma between hepatitis B- and C-viral infection in Japan (Shiratori et al). 1995;22:1027-33

The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan (Hayashi et al). 1995;22:1702-7

A clinical study of lectin-reactive alpha fetoprotein as an early indicator ofhepatocellular carcinoma in the follow- up of cirrhotic patients (Shirake et al). 1995;22:802-7

Clonality in hepatocellular carcinoma: analysis of methylation pattern of polymorphic X-chromosome-linked phosphoglycerate kinase gene in females (Kawai et al). 1995;22:112-7

A comparison of the surgical results in patients with hepatitis B virus versus hepatitis C-related hepatocellular carcinoma (Takenaka et al). 1995;22: 20-4

Differential display and integrin alpha 6 messenger RNA overexpression in hepatocellular carcinoma (Begum et al). 1995;22:1447-55


Expression of intercellular adhesion molecule-1 in human hepatocellular carcinoma (Momosaki et al). 1995;22:1708-13


Hepatic release of erythropoietin induced by transarterial chemoembolization in patients with hepatocellular carcinoma (Pirisi et al). 1995;22:148-52

Hepatocellular carcinoma complicating autoimmune hepatitis: role of hepatitis C virus (Ryder et al). 1995;22:718- 22

Hepatocellular carcinomas associated

with hepatitis B and C virus infec- tions: are they any different (Okuda)? 1995;22:1883-4 (Editorial)

Increased liver iron stores in patients with hepatocellular carcinoma developed on a noncirrhotic liver (Turlin et al). 1995;22:446-50

Induction of sensitivity to ganciclovir in human hepatoceUular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase (Qian et al). 1995;22:118-23


Pathomorphologic characteristics of small hepatocellular carcinoma: a special reference to small hepatocellular with indistinct margins (Nakashima et al). 1995;22:101-5

Serum concentration of intercellular adhesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis (Shimizu et al). 1995;22:525-31

Specific targeting of human hepatocellular carcinoma cells by immunolipases in vitro (Moradpour et al). 1995;22:1527-37

Hepatocyte growth factor (HGF) Activation of Na+/I-I ÷ exchanger by hepa-

tocyte growth factor in hepatocytes (Kaneko et al). 1995;22:629-36

Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases (Arakaki et al). 1995;22:1728-34

Hepatocytes Activation of Na+/H + exchanger by hepa-

tocyte growth factor in hepatecytes (Kaneko et al). 1995;22:629-36

An array of mitochondrial alterations in the hepatocytes of Long-Evans cinnamon rats (Sterulieb et al). 1995;22:1782-7

Cytotoxic activity ofT cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac (Kretz- Rommel and Boelsterli). 1995;22:213- 22

Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture (Mun- tan~-Relat et al). 1995;22:1143-53

Dynamic measurements of the acute and chronic effects of lysosomotropic agents on hepatocyte lysosomal pH

using flow cytometry (Myers et al). 1995;22:1519-26

Effect of anti-ulcer drugs on DNA synthesis in adult normal human hepatocytes in culture (Blanc et al). 1995;22:814-9


Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream (Kennedy et al). 1995;22:160-8







Organellar clusters formed by mitochondrial-rough endoplasmic reticulum associations: an ordered arrangement of mitochondria in hepatocytes (Cas- carano et al). 1995;22:837-46

Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver (Golding et al). 1995;22:1243-53

Phenobarbital modulates the type of cell death by rat hepatocytes during dep- rivation of serum in vitro (Chiao et al). 1995;22:297-303

Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes (Amouzadeh and Pohl). 1995;22:936- 43

Rapid and efficient gene transfer in human hepatocytes by herpes viral factors (Fong et al). 1995;22:723-9

Rat hepatecytes attach to laminin present


in liver biomatrix proteins by an Mg÷+-dependent mechanism (De Lourdes Ponce and Rojkind). 1995;22:620-8






Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes (Gin,s et al). 1995;22:1296-1303


Hepatocytes, periporta l Transforming growth factor ~1 increases


Hepatocytes, perivenular Transforming growth factor ~1 increases


HEPATOLOGY Elsewhere Can a guest liver bring the gift of a gene

to disarm a hostile host (Guha and Chowdhury)? 1995;22:1888-90

Closing in on the "familial cholestasis gene" (Wagstaff and Jones). 1995;22:1611-13

Cyclosporine and liver transplantation: will the midazolam test make blood level monitoring obsolete (Watkins)? 1995;22:994-6

Does interferon therapy for chronic hepatitis B reduce the risks of developing

cirrhosis and hepatocellular carcinoma (Lok). 1995;22:1336-8

Endothelin and vascular reactivity in cirrhosis (Sieber). 1995;22:1609-11

Hepatitis C: IIb (IV) or not IIb (IV) that is the question (Sallie). 1995;22:671- 4

Humoral response to linear B cell epitopes in the amino terminus of the hepatitis C virus envelope glycoprotein gp72 (E2): Role in protective immunity still unknown (Weiner). 1995;22:369-71

Immunosuppression: now we have choices (Sher and Makowka). 1995;22:996-7

In vitro modeling of liver membrane copper transports (Schilsky). 1995;22:1340-2

Keratinocyte growth factor-just another mitogen or the "Holy Grail" that regu- lates liver regeneration (Diehl)? 1995;22:1764-77

The physiology of jaundice: molecular and functional characterization of the Crigler-Najjar syndromes (Berg). 1995;22:1338-40

Platelet-derived growth factor receptor expression in hepatic stellate cells: how too much of a good thing can be bad (Pinzani). 1995;22:997-9

Portal-systemic shunting and portal-systemic encephalopathy: a predictable relationship (Conn). 1995;22:365-6

Transjugular intrahepatic portosystemic shunt: is it the ultimate solution for refractory ascites (Wong and Blendis)? 1995;22:1613-15

Transport proteins and molecular biology: is cloning the beginning or the end (Stump et al)? 1995;22:669-71

Uridine diphosphate glucuronosyl transferases, candidate antigens of liver- kidney microsomal antibodies in hepatitis delta virus-infected patients (Bonino and Brunetto) 1995;22:674-6

Hepatoma Hepatoma cell-specific expression of a ret-



Hepatotoxicity Diclofenac-associated hepatotoxicity:


T-cell-mediated autologous hepatotoxicity in patients with chronic hepatitis C virus infection (Liaw et al).

1995;22:1368-73 Hepatotrophic factor

Rote ofheparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy (Kiso et al). 1995;22:1584-90

Hep G2 cells Intracellular pH regulation in Hep G2

cells: effects of epidermal growth factor, transforming growth factor-a, and insulinlike growth factor-II on Na+/H + exchange activity (Strazza- bosco et al). 1995;22:588-97

Herpes simplex virus thymidine kinase Induction of sensitivity to ganciclovir in


Herpes viral factors Rapid and efficient gene transfer in hu-

man hepatocytes by herpes viral factors (Fong et al). 1995;22:723-9

Histochemistry Expression of glycoconjugates during in-


Histological analysis Fc receptors in liver sinusoidal endothe-



The virological and histological states of anti-hepatitis C virus-positive sub- jects with normal liver biochemical values (Shindo et al). 1995;22:418-25

Histopathology Intrahepatic cholangiographic appear-


Homocysteinemia Carbon tetrachloride-induced hepatic in-


Homozygotes Screening for hemochromatosis in chil-

dren of homozygotes: prevalence and cost effectiveness (Adams et al). 1995;22:1720-7

Hormones


Defective corticotropin-releasing hormone mediated neuroendocrine and behavioral responses in cholestatic rats; implications for cholestatic liver disease-related sickness behaviors (Swain et al). 1995;22:1560-4

Horseradish peroxidase Brefeldin A inhibits the transcytotic vesic-


Host factors Fulminant hepatitis associated with hep-

atitis B virus e antigen-negative infection: importance of host factors (Karayiannis et al). 1995;22:1628-34

Host immune response Induction of T-helper cell response to hep-


Humoral immunity Beneficial effects of intravenous albumin


Humoral response to linear B cell epitopes in the amino terminus of the hepatitis C virus envelope glycoprotein gp72 (E2): Role in protective immunity still unknown (Weiner), 1995;22:369-71 (HEPATOLOGY Elsewhere)

Hydroxycholesterol Serum 7a-hydrexycholesterel as a new pa-

rameter of liver function in patients with chronic liver diseases (Kuroki et al). 1995;22:1182-7

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

Hepatobiliary transport of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors conjugated with bile acids (Petzinger et al). 1995;22:1801-11

Hyperdynamic circulation Increased production of nitric oxide by

neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation (Laffi et al). 1995;22:1666-73

Hyperplasia Management of focal nodular hyperplasia


Hypertransaminasemia Prevalence of hypertransaminasemia in


Hyporesponsiveness

Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats (Weigert et al). 1995;22:1856-62

Hypothermia Protective effects of N-acetylcysteine on


I

IgG-immune complexes Fc receptors in liver sinusoidal endothe-


IgM Immunoglobulin M antibody to hepatitis

C viruis core antigen: correlations with viral replication, histological activity, and liver disease outcome (Quiroga et al). 1995;22:1635-40


Immune complexes Fc receptors in liver sinusoidal endothe-


Immune mechanisms Immune mechanisms of alcohol-induced

liver disease (Klassen et al). 1995;22:355-7 (Editorial)

Immunity modeling In vitro activation of woodchuck lympho-

cytes measured by radiopurine incorporation and interleukin-2 production: implications for modeling immunity and therapy in hepatitis B virus infection (Cote and Gerin). 1995;22:687-99

Immunization Cytotoxic activity ofT cells and non-T cells


Immunoglobulins Hepatic sinusoidal endothelial cells can

store and metabolized serum immunoglobulin (Iwamura et al). 1995;22:1456-61


Immunohistochemistry Expression of glycoconjugates during in-


Focal lymphocytic aggregates in chronic hepatitis C: occurence, immtmohisto- chemical characterization, and relation to markers of autoimmunity (Freni et al). 1995;22:389-94

Immunolipases Specific targeting of human hepatocellu-

lar carcinoma cells by immunolipases in vitro (Moradpour et al). 1995;22:1527-37

Immunology Gastrointestinal and Hepatic Immunol-

ogy (Koff). 1995;22:373 (Book review) lmmunoreactivity

Humoral response to linear B cell epitopes in the amino terminus of the hepatitis C virus envelope glycopretein gp72 (E2): Role in protective immunity still unknown (Weiner). 1995;22:369-71 (HEPATOLOGY Elsewhere)


p53 protein immunoreactivity in extrahepatic bile duct and gallbladder cancer: correlation with tumor grade and survival (Diasmantis et al). 1995;22:774- 9


Immunosuppression Effect of immunosuppressive and antivi-


Evidence for spontaneous immunosuppression in autoimmune hepatitis (Lohse et al). 1995;22:381-8

Immunosuppression: now we have choices (Sher and Makowka). 1995;22:996-7 (HEPATOLOGY Elsewhere)

Inactivation Inactivation of Kupffer cells after pro-

longed donor fasting improves viabil- ity of transplanted hepatic allografts (Sankary et al). 1995;22:1236-42

Inactive precursor Evidence for the presence of an inactive

precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases (Arakaki et al). 1995;22:1728-34

Incidence Screening for hepatocellular carcinoma in

chronic carriers of hepatitis B virus:


incidence and prevalence of hepatocellular carcinoma in a North Ameri- can urban population (Sherman et al). 1995;22:432-8

Independent modulat ion Independent modulation of galactose-spe-

cific receptor expression in rat liver cells (Massimi et al). 1995;22:1819-28

Indist inct margins Pathomorphologic characteristics of small

hepatocellular carcinoma: a special reference to small hepatocelhilar with indistinct margins (Nakashima et al). 1995;22:101-5

I n d i u m - I l l Parenchymal and nonparenchymal up-

take of technetium-99m, indium-i l l , and iodine-125 low-density lipoprotein in the normal and estradiol-stim- ulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy (Leitha et al). 1995;22:1289-95

Induction Differential effects of cytokines on the in-


Differential expression and release of CD54 induced by cytokines (Mickel- son et al). 1995;22:866-875

Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats (Weigert et al). 1995;22:1856-62

Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression (Laskin et al).

Hepatic release of erythropoietin induced by transarterial chemoembolization in patients with hepatocellular carcinoma (Pirisi et al). 1995;22:148-52


Infants The significance of spontaneous hepatitis

B e antigen seroconversion in child- hood; with special emphasis on the clearance of hepatitis B e antigen before three years of age (change et al). 1995;22:1387-92

Infection Macrophage function in cirrhosis and the

risk of bacterial infection (Guarner and Runyon). 1995;22:367-8 (HEPA- TOLOGY Elsewhere)

Infectious diseases Principle and practice of infectious dis-

eases. Ed. 4 (Treadwell). 1995;22:1894 (Book review)

Infiltrates Limited usage of T-cell receptor ~ chains


InflAmmatory response, hepatic Endotoxin and interleukin-1 related he-

patic inflammatory response promotes liver failure after partial hepatectomy (Boermeester et al). 1995;22:1499-1506

Infusion Beneficial effects of intravenous albumin


Blunted natriuretic response to low-dose brain natriuretic peptide infusion in nonazotemic cirrhotic patients with ascites and avid sodium retention (La Villa et al). 1995;22:1745-50

Effects of branched-chain amino acid infusion on protein metabolism in rats with acute hepatic failure (Miwa et al). 1995;22:291-6

Inhibit ion Brefeldin A inhibits the transcytotic vesic-



The growth inhibitory effects of vitamins K and their actions on gene expression (Wang et al). 1995;22:876-82


Inhibition of gallbladder emptying decreases cholesterol saturation in bile in the Richardson ground squirrel (Pauletzki et al). 1995;22:325-31






"Inhibition in solution" assay Anti-hepatitis B virus activity of a mix-

ture of two monoclonal antibodies in an "inhibition in solution" assay (Heijtink et al). 1995;22:1078-83

Injury Acetaminophen-induced microvascular


Inner-city neighborhoods Hepatitis B virus infection in high-risk in-

ner-city neighborhoods in San Fran- cisco (Siegel et al). 1995;22:44-9

In situ nuclear local ization Nuclear scaffold-associated protease: in

situ nuclear localization and effects of a protease inhibitor on growth and morphology of a ras-transformed hepatocyte cell line (Clawson et al). 1995;22:1230-5

Insul in l ike growth factor II (IGF-II) Hepatoma cell-specific expression of a ret-


Intracellular pH regulation in Hep G2 cells: effects of epidermal growth factor, transforming growth factor-a, and insulinlike growth factor-II on Na+/H ÷ exchange activity (Strazza- bosco et al). 1995;22:588-97

Integration Integration of hepatitis B virus and alter-

ation of the lp36 region found in can- cerous tissue of primary hepatocellular carcinoma with viral replication evidenced only in noncancerous, cirrhotic tissue (Simon and Cart). 1995;22:1393-8

In tegr in alpha 6 Differential display and integrin alpha 6


Integr i ty The integrity of the cholecystokinin recep-


Intercellular adhesion molecule-1 (ICAM-1)

Expression of intercellular adhesion molecule-1 in human hepatocellular carcinoma (Momosaki et al). 1995;22:1708-13


In ter feron (IFN) Antipyrine clearance and response to in-

terferon treatment in patients with chronic active hepatitis C (Coverdale et al). 1995;22:1065-71

Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment (Koizumi et al). 1995;22:30-5

Does interferon precipitate rejection of liver allografts (Min and Boden- heimer)? 1995;22:1333-5 (Editorial)




Interferon a (IFN-a) The differential effects of three forms of

interferon alfa on hepatic regeneration after partial hepatectomy in the rat (Wong et al). 1995;22:883-6



Expression of transforming growth factor alpha in the liver before and after interferon alfa therapy for chronic hepatitis B (Morimitsu et al). 1995;22:1021-6

Long-term decrease in serum N-terminal propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alfa (Suou et al). 1995;22:426-31

An open trial of interferon alfa recombinant for hepatitis C after liver transplantation: antiviral effects and risk of rejection (F~ray et al). 1995;22:1084-9

Predictors of a sustained beneficial re~ spouse to interferon alfa therapy in chronic hepatitis C (Conjeevaram et al). 1995;22:1326-9 (Editorial)


Recombinant interferon-alfa therapy in

children with chronic hepatitis C (Bortolotti et al). 1995;22:1623-7


Interferon 2a (IFN-2a) Randomized trial comparing three differ-

ent regimens of alpha-2a-interferon in chronic hepatitis C (Chemello et al). 1995;22:700-6

Interferon ~/(IFN- T) Interferon gamma production by periph-


In te r leuk in 1 (IL-1) Endotoxin and interleukin-1 related he-

patic inflammatory response promotes liver failure after partial hepa- toctomy. 1995;22:1499-1506

Interleukin-1 and nitric oxide protect against tumor necrosis factor-a-induced liver injury through distinct pathways (Bohlinger et al). 1995;22:1829-37

Interleukin 1~ (IL-lfl) Downregulation of phorbol 12-myristate

13-acetate-induced tumor necrosis factor-alpha and interleukin-l~ production and gene expression in human monocytic cells by human alpha- fetoprotein (Wang and Alpert). 1995;22:921-8

Synthesis of interleukin-l~ in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression (Miller et al). 1995;22:518-24

In te r leuk in 2 (IL-2) In vitro activation of woodchuck lympho-


In te r leuk in 6 (IL-6) Regulation of gene expression by interleu-

kin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone (Roncero et al). 1995;22:1769-75

Interleukin 10 (IL-10) Role of defective monocyte interleukin-10

release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis (Le Moine et al). 1995;22:1436-9

Intest ine Iron-responsive element-binding protein

in hemochromatosis liver and intes- tine (Flanagan et al). 1995;22:828-32

Intracellular adhesion molecule 1 (ICAM-1)

Serum concentration of intercellular ad-

hesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis (Shimizu et al). 1995;22:525-31


Intravenous infusion Beneficial effects of intravenous albumin


In t ravenous supplementat ion Choline deficiency; a cause of hepatic


I n v i t ro activation In vitro activation of woodchuck lympho-


I n v i t ro expression In vivo and in vitro expression of defective

hepatitis B virus particles generated by spliced hepatitis B virus RNA (Rosmorduc et al). 1995;22:10-19

In v i t ro maintenance Improved hepatocyte in vitro mainte-

nance in a culture model with woven multicompartment capillary systems: electron microscopy studies (Gerlach et al). 1995;22:546-52

In v i t ro model ing In vitro modeling of liver membrane cop-


I n v i t ro study A morphological study of differentiated

hepatocytes in vitro (Arterburn et al). 1995;22:175-87

In v i t ro targeting Specific targeting of human hepatocellu-

lar carcinoma cells by immunolipases in vitro (Moradpour et al). 1995;22:1527-37

In vivo express ion In vivo and in vitro expression of defective


In vivo transfection In vivo transfection of hepatitis C virus


Iodine-125 Parenchymal and nonparenchymal up-


take of technetium-99m, indium-Il l , and iodine-125 low-density lipoprotein in the normal and estradiol-stim- ulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy (Leitha et al). 1995;22:1289-95

Iron depletion Portal hypertension and iron depletion in

patients with genetic hemochromatosis (Fracanzani et al). 1995;22:1127- 31

Iron-responsive element-binding protein

Iron-responsive element-binding protein in hemochromatosis liver and intes- tine (Flanagan et al). 1995;22:828-32

Iron stores, hepatic Increased liver iron stores in patients with

hepatocellular carcinoma developed on a noncirrhotic liver (Turlin et al). 1995;22:446-50

Ischemia The effect of prostaglandin E1 on liver ade-


Ischemia-reperfusion in ju ry Protective effects of N-acetylcysteine on


Isoprostanes Excretion of F2-isoprostanes in bile: a

novel index of hepatic lipid peroxidation (Awad and Morrow). 1995;22:962-8

Isosorbide-5-mononitrate Long-term effect of nadolol or nadolol plus

isosorbide-5-mononitrate on renal function and ascites formation in patients with cirrhosis (Merkel et al). 1995;22:808-13

Ito cells Spl binding activity increases in activated


J

Japanese populations Characteristic difference of hepatocellular

carcinoma between hepatitis B-and C-viral infection in Japan (Shiratori et ai). 1995;22:1027-33

The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan (Hayashi et ai). 1995;22:1702-7


Jaundice

The physiology of jaundice: molecular and functional characterization of the Crigler-Najjar syndromes (Berg). 1995;22:1338-40 (HEPATOLOGY Elsewhere)

K

Keratinocyte growth factor (KGF) Keratinocyte growth factor-just another

mitogen or the "Holy Grail" that regu- lates liver regeneration (Diehl)? 1995;22:1764-77 (HEPATOLOGY Elsewhere)

Kidneys Efficacy and safety of interferon alfa ther-

apy in chronic hepatitis C with autoantibodies to liver-kidney microsomes (Todros et al). 1995;22:1374-8

Long-term effect of nadolol or nadolol plus isosorbide-5-mononitrate on renal function and ascites formation in patients with cirrhosis (Merkel et al). 1995;22:808-13


Kinetics Changes in platelet kinetics after a partial

splenic arterial embolization in cirrhotic patients (Noguchi et al). 1995;22:1682-8

Kupffer cells Cytokine gene expression by Kupffer cells




Inactivation of Kupffer cells after pro- longed donor fasting improves viabil- ity of transplanted hepatic allografts (Sankary et al). 1995;22:1236-42

Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: characterization and expression in cultured cells (Win- wood et al). 1995;22:304-15

The role of Kupffer cells in the differentiation process of hepatic natural killer cells (Vanderkerken et al). 1995;22:283-90

L

Laboratory features Primary sclerosing cholangitis in 32

children; clinical, laboratory, and radiographic features, with survival analysis (Wilschanski et al). 1995;22:1415-22

Lactosaminated polyoL-lysine Inhibition of woodchuck hepatitis virus

replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route (Fiume et al). 1995;22:1072-7

Lamin in Differential expression of A and B laminin

chains during rat liver regeneration (Gim~nez et al). 1995;22:1259-62

Rat hepatocytes attach to laminin present in liver biomatrix proteins by an Mg+÷-dependent mechanism (De Lourdes Ponce and Rojkind). 1995;22:620-8

Lectin-histochemical study Expression of glycoconjugates during in-


Lectins A clinical study of lectin-reactive alpha

fetoprotein as an early indicator ofhepatocellular carcinoma in the follow- up of cirrhotic patients (Shirake et al). 1995;22:802-7

Leukotrienes Metabolism of cysteinyl leukotrienes in


LeVeen shunt Treatment of patients with cirrhosis and

refractory ascites using LeVeen shunt with titanium tip: comparison with therapeutic paracentesis (Gin,s et al). 1995;22:124-31

Ligation A prospective, randomized trial of sclero-

therapy versus ligation in the management of bleeding esophageal varices (Lo et al). 1995;22:466-71

Lipid peroxidation, hepatic Excretion of F2-isoprostanes in bile: a

novel index of hepatic lipid peroxidation (Awad and Morrow). 1995;22:962-8

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease (Niemel~i et al). 1995;22:1208- 14

Lipids Effects of liver transplantation on bile for-

mation and biliary lipid secretion in the Sprague-Dawley rat (Chan et al). 1995;22:1254-8

Lipopolysaccharides Vascular adhesion molecule-1 and intra-


cellular adhesion molecule-1 expression on rat liver cells after lipopoly- saccharide administration in vivo (van Oosten et al). 1995;22:1538

Liver, fatty nonalcohol ic The natural history of nonalcoholic fatty

liver: a follow-up study (Teli et al). 1995;22:1714-9

Liver, noncirrhotic Increased liver iron stores in patients with

hepatocellular carcinoma developed on a noncirrhotic liver (Turlin et al). 1995;22:446-50

Liver, normal The virological and histological states of

anti-hepatitis C virus-positive sub- jects with normal liver biochemical values (Shindo et al). 1995;22:418-25

Liver, perinatal Coexpression of liver-specific and growth-


Liver, postnatal growth Experiments in transgenic mice show that

hepatocytes are the source for postnatal liver growth and do not stream (Kennedy et al). 1995;22:160-8

Liver disease Diagnosis and management of liver dis-

ease (Koff). 1995;22:1893-4(Book review)


Fatigue associated with chronic liver disease: a riddle wrapped in a mystery inside an enigma (Jones). 1995;22:1606-8 (Editorial)


Intrahepatic mast cells in chronic liver diseases (Farrell et al). 1995;22:1175- 81

Relationship between cardiomyopathy and liver disease in chronic alcoholism (Estruch et al). 1995;22:532-8

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease (Niemel~i et al). 1995;22:1208- 14

Serum 7a-hydroxycholesterol as a new pa- rameter of liver function in patients with chronic liver diseases (Kuroki et al). 1995;22:1182-7

Viral hepatitis and liver disease (Koff). 1995;22:1000 (Book review)

Liver disease, end-stage


Liver disease, outcome Immunoglobulin M antibody to hepatitis

C virus core antigen: correlations with viral replication, histological activity, and liver disease outcome (Quiroga et al). 1995;22:1635-40

Liver distribution Hepatic distribution of E2 component of


Liver enzymes, normal Hepatitis C viral quasispecies in hepatitis

C virus carriers with normal liver enzymes and patients with type C chronic liver disease (Naito et al). 1995;22:407-12

Liver failure Chronic hepatitis and hepatic failure in a




Endotexin and interleukin-1 related hepatic inflammatory response promotes liver failure after partial hepatectomy. 1995;22:1499-1506

Effects of branched-chain amino acid infusion on protein metabolism in rats with acute hepatic failure (Miwa et al). 1995;22:291-6

Proton spectroscopy of brain glutamine in acute liver failure (McConnell et al). 1995;22:69-74

Liver function Serum 7a-hydroxycholesterol as a new pa-

rameter of liver function in patients with chronic liver diseases (Kuroki et al). 1995;22:1182-7

Liver function test The liver-spleen scan as a quantitative

liver function test: correlation with liver severity at peritoneoscopy (Hoers et al). 1995;22:1113-21

Liver genes Coexpression of liver-specific and growth-


Liver in jury Acetaminophen-induced microvascular


Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment (Varela-Moreiras et al). 1995;22:1310-5


Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver (Nakano et al). 1995;22:539-45

Thrombin stimulates proliferation of liver fat-stering cells and expression of monocyte chemotactic protein-l: potential role in liver injury (Marra et al). 1995;22:780-7


Liver-kidney microsomes Efficacy and safety of interferon alfa ther-



Liver perfusion Nitric oxide donor prevents hepatic and

systemic perfusion decrease induced by endotoxin in anesthetized rabbits (Pastor et al). 1995;22:1547-53

Liver severity The liver-spleen scan as a quantitative

liver function test: correlation with liver severity at peritoneoscopy (Hoers et al). 1995;22:1113-21

Liver-spleen scan The liver-spleen scan as a quantitative

liver function test: correlation with liver severity at peritoneoscopy (Hoefs et al). 1995;22:1113-21

Liver surgery Surgery of the liver and biliary tract

(Rossi). 1995;22:1616 (Book review) Localization



Locomotor activity Disruption of circadian locomotor activity


Long.Evans cinnamon rats An array of mitochondrial alterations in


Low-density Hpoprotein Parenchymal and nonparenchymal up-


Low-flow, reflow liver perfusion model A fish oil diet minimizes hepatic reperfu-


Luminal antigens Processing of endoplasmic reticulum lu-

minal antigens associated with halothane hepatitis in rat hepatocytes (Amouzadeh and Pohl). 1995;22:936- 43

Lungs Flow-cytometric DNA-ploidy and prolifer-


Lymphocytes Interferon gamma production by periph-


In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin-2 production: implications for modeling immunity and therapy in hepatitis B virus infection (Cote and Gerin). 1995;22:687-99

Limited usage of T-cell receptor/~ chains and sequences of the complementarity determining region 3 of lymphocytes infiltrating in the liver of autoimmune hepatitis (Hoshino et al). 1995;22:142-7

Lymphoma cells, massively disseminated


Lysosomes Dynamic measurements of the acute and

chronic effects of lysosomotropic

agents on hepatocyte lysosomal pH using flow cytometry (Myers et al). 1995;22:1519-26

Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes (Nakano et al. 1995;22:262-6

Lysosomotropic agents Dynamic measurements of the acute and


M

Macrophages Differential activation of transcription


Macrophage function in cirrhosis and the risk of bacterial infection (Guarner and Runyon). 1995;22:367-8 (HEPA- TOLOGY Elsewhere)

Magnetic resosnance imaging (MRI) Decreased right heart blood volume deter-

mined by magnetic resonance imaging: evidence of central underfllling in cirrhosis (M¢ller et al). 1995;22:472-8

Massive dissemination Creatine kinase BB: markedly increased


Mast cells, intrahepatie Intrahepatic mast cells in chronic liver

diseases (Farrell et al). 1995;22:1175- 81

Mastocytosis Hepatic involvement in mastocytosis: clin-

icopathologic correlations in 41 cases (Mican et al). 1995;22:1163-70

Maternal infection The influence of a maternal chronic hepa-


Mechanism of increase Serum carbohydrate-deficient trans-

ferrin; mechanism of increase after chronic alcohol intake (Xin et al). 1995;22:1462-8

Membrane, hepatic In vitro modeling of liver membrane cop-


Messenger RNA Differential display and integrin alpha 6

messenger RNA overexpression in he-

patocellular carcinoma (Begum et al). 1995;22:1447-55

Meta.analytic review The treatment of portal hypertension: a

meta-analytic review (D'Amico et al). 1995;22:332-54 (Special article)

Metabolic nitrogen exchange Advances in hepatic encephalopathy and


Metabolism Effects of branched-chain amino acid infu-





Metastases Flow-cytometric DNA-ploidy and prolifer-


Methotrexate The combination of ursodeoxycholic acid

and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study (Lindor et al). 1995;22:1158-62

Synthesis of interleukin-1/3 in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression (Miller et al). 1995;22:518-24

Metbylation Clonality in hepatocellular carcinoma:


Methylmercury Impaired biliary excretion and whole body


Mg+ +-dependent mechanism Rat hepatocytes attach to laminin present

in liver biomatrix proteins by an Mg+÷-dependent mechanism (De Lourdes Ponce and Rojkind). 1995;22:620-8

Microcrystals Deoxycholic acid influences cholesterol



Micropig model Sequential acetaldehyde production, lipid


Microsomes Efficacy and safety of interferon alfa ther-



Microvascular injury Acetaminophen-induced microvascular

injury in the rat liver: protection with misoprostel, Lira et al). 1995;22:1776- 81

Midazolam test Cyclosporine and liver transplantation:


Misoprostol Acetaminophen-induced microvascular

injury in the rat liver: protection with misoprosto1, Lira et al). 1995;22:1776- 81

Mitochondria Abnormal expression of PDC-E2 on the


An array of mitechondrial alterations in the hepatocytes of Long-Evans cinnamon rats (Sternlieb et al). 1995;22:1782-7


Organellar clusters formed by mitochondrial-rough endoplasmic reticulum associations: an ordered arrangement of mitechondria in hepatocytes (Cas- carano et al). 1995;22:837-46

Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats (Kr~ihenbtihl et al). 1995;22:607- 12

Mitogens Keratinocyte growth factor-just another

mitogen or the "Holy Grail" that regu- lates liver regeneration (Diehl)? 1995;22:1764-77 (HEPATOLOGY Elsewhere)



Modulation Independent modulation of galactose-spe-

cific receptor expression in rat liver cells (Massimi et al). 1995;22:1819-28

Molecular biology Transport proteins and molecular biology:

is cloning the beginning or the end (Stump et al)? 1995;22:669-71 (HEP- ATOLOGY Elsewhere)

Molecular characterization The physiology of jaundice: molecular and


Molecular dissection Molecular dissection of the mitogenic ef-

fect of hepatocytes on cultured hepatic stellate cells (Gressner et al). 1995;22:1507-18

Monoclonal antibodies Fc receptors in liver sinusoidal endothe-



Monocyte chemotactic protein-1 Thrombin stimulates proliferation of liver

fat-storing cells and expression of monocyte chemotactic protein-l: potential role in liver injury (Marra et al). 1995;22:780-7

Monocytes Dowuregnlation of phorbol 12-myristate

13-acetate-induced tumor necrosis factor-alpha and interleukin-l~ production and gene expression in human monocytic cells by human alpha- fetoprotein (Wang and Alpert). 1995;22:921-8


Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis (Le Moine et al). 1995;22:1436-9

Morphology



Mosaicism Peroxisome mosaicism in the livers of per-

oxisomal deficiency patients (Espeel et al). 1995;22:497-504

Mouse hepatitis virus type 3 Mouse hepatitis virus type 3 infection pro-

vokes a decrease in the number of sinusoidal endothelial cell fenestrae both in vivo and in vitro (Steffan et al). 1995;22:395-401

Mucin-vesicle interactions Mucin-vesicle interactions in model bile:


Mult idiscipl inary management Hepatobiliary malignancy: its multidisci-

plinary management (Meyers). 1995;22:1000 (Book review)

Multivariate analysis Polymorphisms in alcohol metabolizing

enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis (Yamauchi et al). 1995;22:1136-42

Murine mutations Introduction of a murine p53 mutation

corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation (Dumenco et al). 1995;22:1279-88

Mutations The clinical significance of p53 gene muta-


Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line re- suits in growth advantage, but not in transformation (Dumenco et al). 1995;22:1279-88

Naturally occurring hepatitis B virus core gene mutations (Akarca and Lok. 1995;22:50-60

Proliferative response ofCD4 ÷ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (LShr et al). 1995;22:61-8

Myofibroblastlike cells Human myofibroblastlike cells obtained

by outgrowth are representative of the fibrogenic cells in the liver (Bla- zejewski et al). 1995;22:788-97


N

Na÷/H ÷ exchange Activation of Na+/H + exchanger by hepa-

tocyte growth factor in hepatocytes (Kaneko et al). 1995;22:629-36

Intracellular pH regulation in Hep G2 cells: effects of epidermal growth factor, transforming growth factor-a, and insulinlike growth factor-II on Na÷/H ÷ exchange activity (Strazza- bosco et al). 1995;22:588-97

Nadolol Long-term effect of nadolol or nadolol plus


National Digest ive Diseases Advisory Board


Natriuretic response Blunted natriuretic response to low-dose


Natural history The natural history of nonalcoholic fatty

liver: a follow-up study (Teli et al). 1995;22:1714-9

Natural ki l ler cel ls The role of Kupffer cells in the differentia-

tion process of hepatic natural killer cells (Vanderkerken et al). 1995;22:283-90

Neoplast ic potential Primary sclerosing cholangitis and ulcera-


Neuroendocrine responses Defective corticotropin-releasing hormone


Neurohormonal sys tems Effect of upright posture and physical ex-

ercise on endogenous neurohormonal systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldosterone, and norepinephrine levels (Sal6 et al). 1995;22:479-87

Neutrophils Increased production of nitric oxide by

neutrophils and monocytes from cirrhotic patients with ascites and hy-

perdynamic circulation (Laffi et al). 1995;22:1666-73

Nitric oxide Hepatic nitric oxide production following

acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression (Laskin et al).





Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis (Ros et al). 1995;22:915-20


Nitric oxide synthase Endothelium-dependent vascular hypore-


Enhanced nitric oxide synthase activity in portal hypertensive rabbits (Cahill et al). 1995;22:598-606

Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression (Laskin et al).

Nitrogen Advances in hepatic encephalopathy and


NK-KB transcription factor Differential activation of transcription


Nodular hepatocel lular les ions Terminology of nodular hepatocellular le-

sions (International Working Party).1995;22:983-93 (Special article)

Nodular hyperplasia Management of focal nodular hyperplasia

and hepatocellular adenoma in young women: a series of 41 patients with

clinical, radiological, and pathological correlations (Cherqui et al). 1995;22:1674-81

Nonazotemia Blunted natriuretic response to low-dose


Noncancerous t issue Integration of hepatitis B virus and alter-


Noninvasive 24-hour ambulatory arterial blood pressure monitor ing

Noninvasive 24-hour ambulatory arterial blood pressure monitoring in cirrhosis (M¢ller et al). 1995;22:88-95

Norepinephrine Effect of upright posture and physical ex-


Normothermic hepatic i schemia The effect of prostaglandin E1 on liver ade-


North American urban population Screening for hepatocellular carcinoma in

chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North Ameri- can urban population (Sherman et al). 1995;22:432-8

Notices, 1995;22:374-9, 1995;22:681-6, 1995;22:1013-8, 1995;22:1345-9, 1995;22:1620-2, 1995;22:1895-7

NS3 serine proteinase Proteolytic activity of NS3 serine protein-


N-terminal propeptide Long-term decrease in serum N-terminal

propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alfa (Suou et al). 1995;22:426-31

Nuclear factor kappa B Vitamin E therapy of acute CC14-induced

hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding (Liu et al). 1995;22:1474-81

Nuclear scaffold-associated protease Nuclear scaffold-associated protease: in

situ nuclear localization and effects of


a protease inhibitor on growth and morphology of a ras-transformed hepatocyte cell line (Clawson et al). 1995;22:1230-5

Nucleation time Deoxycholic acid influences cholesterol


Nucleotides The effect of prostagiandin E1 on liver ade-


NZB/W F1 lupus mice Fc receptors in liver sinusoidal endothe-

lial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2) (Ahmed et al). 1995;22:316-24

O

Obesity The integrity of the cholecystokinin recep-


Oligonucleotides Specific inhibition of hepatitis C viral


lp36 region Integration of hepatitis B virus and alter-


Open t r ial An open trial of interferon alfa recombi-


Ordered arrangement Organellar clusters formed by mitochon-


Organellar clusters Organellar clusters formed by mitechon-


Outcome Effect of donor age and sex on the outcome


Outgrowth

Human myoflbroblastlike cells obtained by outgrowth are representative of the fibrogenic cells in the liver (Bla- zejewski et al). 1995;22:788-97

Oval cells Oval cell differentiation into hepatocytes

in the acetylaminofluorene-treated regenerating rat liver (Golding et al). 1995;22:1243-53

Overexpression Differential display and integrin alpha 6


Overproduction Role of defective monocyte interleukin-10

release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis (Le Moine et al). 1995;22:1436-9

P

p53 gene The clinical significance of p53 gene muta-



p53 proteins p53 protein immunoreactivity in extrahe-


p53 proteins and aflatoxin BI: the good, the bad, and the ugly (Liang). 1995;22:1330-2 (Editorial)

Paracetamol Acetaminophen (paracetamol) hepatotox-

icity with regular intake of alcohol: analysis of instances of therapeutic misadventure (Zimmerman and Mad- drey). 1995;22:767-73

Parenchyma Pareuchymal and nonparenchymal up-

take of technetium-99m, indium-i l l , and iodine-125 low-density lipopro- rein in the normal and estradiol-stim- ulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy (Leitha et al). 1995;22:1289-95

Parenteral nutrition Choline deficiency; a cause of hepatic


Paraumbilical vein patency Paraumbilical vein patency in cirrhosis:

effects on hepatic hemodynamics

evaluated by Doppler sonography (Sacerdoti et al). 1995;22:1689-94

Par t ia l hepatectomy The differential effects of three forms of

interferon alfa on hepatic regeneration after partial hepatectomy in the rat (Wong et al). 1995;22:883-6

The effect of partial hepatectomy on tumor growth in rats: in vivo and in vitro studies (deJong et al). 1995;22:1263-72

Endotoxin and interleukin-1 related hepatic inflammatory response promotes liver failure after partial hepatectomy. 1995;22:1499-1506


Par t ia l splenic ar ter ia l embolization Changes in platelet kinetics after a partial


Parvovirus B19 Parvovirus B19 as a possible causative

agent of fulminant liver failure and associated aplastic anemia (Langnas et al). 1995;22:1661-5

Patency Paraumbilical vein patency in cirrhosis:

effects on hepatic hemodynamics evaluated by Doppler sonography (Sacerdoti et al). 1995;22:1689-94

Pathobiology The Liver. Biology and Pathobiology. Ed

3 (Riely et al). 1995;22:372 (Book review)

Pathogenesis Calcium carbonate in cholesterol gall-


Pathological correlations Management of focal nodular hyperplasia


Pathology Pathology: state of the art reviews. Diag-

nostic problems in liver pathology (Lis). 1995;22:1892 (Book review)

Pathomorphologic characteristics Pathomorphologic characteristics of small

hepatocellular carcinoma: a special reference to small hepatocellular with indistinct margins (Nakashima et al). 1995;22:101-5

PDC-E2 Abnormal expression of PDC-E2 on the

apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary bill-


ary cirrhosis (Tsuyenama et al). 1995;22:1440-6

Perfusion Carrier-mediated uptake and excretion of


A fish oil diet minimizes hepatic reperfusion injury in the low-flow, reflow liver perfusion model (Zhong and Thurman). 1995;22:929-35


Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state (Wettstein et al). 1995;22:235-40


Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis (Ros et al). 1995;22:915-20

Sulfation of acetaminophen by the perfused rat liver: the effect of red blood cell carriage (Pang et al). 1995;22:267-82

Peripheral blood lymphocytes Interferon gamma production by periph-


Peritonescopy The liver-spleen scan as a quantitative


Peritonitis Ciprofloxacin and long-term prevention of

spontaneous bacterial peritonitis: results of a prospective controlled trial (Rolachon et al). 1995;22:1171-4

Peroxisomes Alterations of peroxisomes in steatosis of

the human liver: a quantitative study (De Craemer et al). 1995;22:744-52

Peroxisome mosaicism in the livers ofper- oxisomal deficiency patients (Espeel et al). 1995;22:497-504

Persistence Persistent hepatitis C virus infection after

liver transplantation: clinical and virological features (Gretch et al). 1995;22:1-9

pH, intracel lular Dynamic measurements of the acute and

chronic effects of lysosomotropic agents on hepatocyte lysosomal pH

using flow cytometry (Myers et al). 1995;22:1519-26

Intracellular pH regulation in Hep G2 cells: effects of epidermal growth factor, transforming growth factor-a, and insulinlike growth factor-II on Na+/H + exchange activity (Strazza- bosco et al). 1995;22:588-97

Transforming growth factor B1 increases the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes (Benedetti et al). 1995;22:1488-97

Phenobarbital Phenobarbital modulates the type of cell

death by rat hepatocytos during dep- rivation of serum in vitro (Chiao et al). 1995;22:297-303

Phorbol esters Tyrosine kinase growth factor receptors

but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes (Gin,s et al). 1995;22:1296-1303

Phorbol 12-myristate 13-acetate Downregulation of phorbol 12-myristate

13-acetate-induced tumor necrosis factor-alpha and interleukin-1/3 production and gene expression in human monocytic cells by human alpha- fetoprotein (Wang and Alpert). 1995;22:921-8

Phosphoglycerate kinase gene Clonality in hepatocellular carcinoma:


Phosphorothioate Specific inhibition of hepatitis C viral


Physical exercise Effect of upright posture and physical ex-

ercise on endogenous neurohormonal systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldostorone, and norepinephrine levels (Sal5 et al). 1995;22:479-87

Physiology The physiology of jaundice: molecular and


Placebo Effects of bolus injections and continuous


A randomized double-blind, placebo-con-

trolled trial of ursodeosycholic acid in primary biliary cirrhosis (Combes et al). 1995;22:759-66

Plasma Effect of upright posture and physical ex-



High plasma levels of atrial natriuretic peptide in preascitic cirrhosis: indi- rect evidence of reduced natriuretic effectiveness of the peptide (Trevisani et al). 1995;22:132-7

Plasma membrane Cardiac plasma membrane physical prop-

erties and/~-adrenergic receptor function are unaltered in portal-hypertensive rats (Ma et al). 1995;22:188-93

Platelet-derived growth factor receptor

Platelet-derived growth factor receptor expression in hepatic stellate cells: how too much of a good thing can be bad (Pinzani). 1995;22:997-9 (HEPA- TOLOGY Elsewhere)

Platelets Changes in platelet kinetics after a partial


Plexiform neurofibromatosis Plexiform neurofibromatosis of the liver:

case report and review of the litera- ture (Ghalib et al). 1995;22:1154-7

Ploidy Flow-cytometric DNA-ploidy and prolifer-


Polymerase chain reaction (PCR) Detection of hepatitis C virus with RNA

polymerase chain reaction in fulminant hepatic failure (Villamil et al). 1995;22:1379-86

Does the healthy hepatitis C virus carrier state really exist? An analysis using polymerase chain reaction (Prieto et al). 1995;22:413-7

Polymorphisms Calcium carbonate in cholesterol gall-


Clonality in hepatocellular carcinoma: analysis of methylation pattern of polymorphic X-chromosome-linked


phosphoglycerate kinase gene in females (Kawai et al). 1995;22:112-7



Porcine model The effect of prostaglandin El on liver ade-


Portal hypertension Acetylcholine-induced vasorelaxation in

portal hypertensive rats (Michielsen et al) (Letter); (Jim~nez) (Reply). 1995;22:1909-11

Cardiac plasma membrane physical prop- erties and ~-adrenergic receptor function are unaltered in portal-hypertensive rats (Ma et al). 1995;22:188-93

Enhanced nitric oxide synthase activity in portal hypertensive rabbits (Cahill et al). 1995;22:598-606

Gastric mucosal hemodynamics in portal- hypertensive gastropathy: the debate goes on (Guslandi and Tittobello) (Letter); (Ohta et al) (Reply). 1995;22:1002-4

Loss of angiotensin-II receptors in portal hypertensive rabbits (Sitzmann et al). 1995;22:559-64

The role of transjugnlar intrahepatic portosystemic shunt for treatment of portal hypertension and its complications: a conference sponsored by the national digestive diseases advisory board (Shiffman et al). 1995;22:1591- 7 (Special article)

The treatment of portal hypertension: a meta-analytic review (D'Amico et al). 1995;22:332-54 (Special article)

Portal-systemic encephalopathy Portal-systemic shunting and portal-sys-

temic encephalopathy: a predictable relationship (Conn). 1995;22:365-6 (HEPATOLOGY Elsewhere)

Portal-systemic shunting Portal-systemic shunting and portal-sys-

temic encephalopathy: a predictable relationship (Corm). 1995;22:365-6 (HEPATOLOGY Elsewhere)

Portal vein embolization Portal vein embolization with steel coils


Portal vein ligation Elevated mitochondrial gene expression

during rat liver regeneration after portal vein ligation (Shimizu et al). 1995;22:1222-9

Portocaval anastomosis Disruption of circadian locomotor activity

in rats after portocaval anastomosis is not gender dependent Steindl et al). 1995;22:1763-8

Postmortem Intrahepatic cholangiographic appear-

ance simulating primary sclerosing cholangitis in several hepatobiliary diseases: a postmortem cholangiographic and histepathological study in 154 livers at autopsy (Terada and Nakanuma). 1995;22:75-81

Precore mutants Hepatitis B virus infection: precore mu-

tants and its relation to viral geno- types and core mutations (Rodriguez- Frias et al). 1995;22:1641-7 Hepatitis B virus precoreYcore variation and in- torferon therapy (Fattovich et al). 1995;22:1355-62

Precursor Evidence for the presence of an inactive


Prevalence Pretreatment serum hepatitis C virus

RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C (Martinot-Peig- noux et al). 1995;22:1050-6

Prevalence of hypertransaminasemia in adult celiac patients and effect of gluten-free diet (Bardella et al). 1995;22:833-6



Pr imary biliary cirrhosis (PBC) Abnormal expression of PDC-E2 on the


Auteantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope (Leung et al). 1995;22:505-13

The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results

of a pilot study (Lindor et al). 1995;22:1158-62

A randomized double-blind, placebo-controlled trial of ursodeosycholic acid in primary biliary cirrhosis (Combes et al). 1995;22:759-66

Synthesis of interleukin-1/~ in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression (Miller et al). 1995;22:518-24

Pr imary cultures Differential effects of cytokines on the in-

ducible expression of CYPIA1, CYPIA2, and CYP3A4 in human hepatocytes in primary culture (Mun- tan~-Relat et al). 1995;22:1143-53

Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture (HiUaire et al). 1995;22:82-7


Pr imary sclerosing cholangitis (PSC) Intrahepatic cholangiographic appear-


Primary sclerosing cholangitis and ulcera- tive colitis; evidence for increased neoplastic potential (Broom~ et al). 1995;22:1404-8

Processing Processing of endoplasmic reticulum lu-

minal antigens associated with halothane hepatitis in rat hepatecytes (Amouzadeh and Pohl). 1995;22:936- 43

Procollagen, type IH Long-term decrease in serum N-terminal

propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alfa (Suou et al). 1995;22:426-31

Prognostic factors Pretreatment serum hepatitis C virus


Prognostic value Prognostic value of clotting and fibrino-

lytic systems in a follow-up of 165 liver cirrhotic patients (Violi et al). 1995;22:96-100

Prognosis Serum concentration of intercellular ad-

hesion molecule-1 in patients with he-


patocellular carcinoma is a marker of the disease progression and prognosis (Shimizu et al). 1995;22:525-31

Prostacyclin Role of nitric oxide and prostacyclin in the


Pros taglandin El The effect ofprostaglandin E1 on liver ade-

nine nucleotides and cytoplasmic enzymes in a porcine mode] of normothermic hepatic ischemia (Helling et al). 1995;22:1554-9

Prostaglandins Feedback-inhibition of glucagon-stimu-


Protease inhibitor Nuclear scaffold-associated protease: in


Protective immunity Humoral response to linear B cell epitopes


Prote in kinase, mitogen-activated Tyrosine kinase growth factor receptors

but not seven-membrane-spanning receptors or phorbol esters activate mitegen-activated protein kinase in rat hepatocytes (Gin,s et al). 1995;22:1296-1303

Proteins Effects of branched-chain amino acid infu-


Iron-responsive element-binding protein in hemochromatosis liver and intes- tine (Flanagan et al). 1995;22:828-32

p53 proteins and aflatoxin BI: the good, the bad, and the ugly (Liang). 1995;22:1330-2 (Editorial)

Rat hepatocytes attach to laminin present in liver biomatrix proteins by an Mg++-dependent mechanism (De Lourdes Ponce and Rojkind). 1995;22:620-8


Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-l: po-

tential role in liver injury (Marra et al). 1995;22:780-7

Transport proteins and molecular biology: is cloning the beginning or the end (Stump et al)? 1995;22:669-71 (HEP- ATOLOGY Elsewhere)


Proteolysis Proteolytic activity of NS3 serine protein-

ase of hepatitis C virus efficiently ex- pressed in Eseherichia coli (Shoji et al). 1995;22:1648-55

Proton spectroscopy Proton spectroscopy of brain glutamine in


Pu lmonary metastases Flow-cytometric DNA-ploidy and prolifer-


Pyruvate dehydrogenase Hepatic distribution of E2 component of


Q

Quantitative liver function test The liver-spleen scan as a quantitative


Quantitative low-density lipoprotein scintigraphy

Parenehymal and nonparenchymal uptake of technetium-99m, indium-i l l , and iodine-125 low-density lipopre- tein in the normal and estradiol-stim- ulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy (Leitha et al). 1995;22:1289-95

Quantitative study Alterations of peroxisomes in steatosis of


Quasispecies Diversity of quasispecies in various dis-

ease stages of chronic hepatitis C virus infection and its significance in interferon treatment (Koizumi et al). 1995;22:30-5


R

Radiographic features Primary sclerosing cholangitis in 32

children; clinical, laboratory, and radiographic features, with survival analysis (Wilschanski et al). 1995;22:1415-22

Radiologcal correlations Management of focal nodular hyperplasia

and hepatoeellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations (Cherqui et al). 1995;22:1674-81

Radiopur ine incorporation In vitro activation of woodchuck lympho-


Randomized t r ia l A randomized double-blind, placebo-con-

trolled trial of ursodeosycholic acid in primary biliary cirrhosis (Combes et al). 1995;22:759-66

Randomized trial comparing three different regimens of alpha-2a-interferon in chronic hepatitis C (Chemello et al). 1995;22:700-6

ras-transformed hepatocyte cell line Nuclear scaffold-associated protease: in


Receptors Cardiac plasma membrane physical prop-

erties and ~-adrenergic receptor function are unaltered in portal-hypertensive rats (Ma et al). 1995;22:188-93

Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2) (Ahmed et al). 1995;22:316-24

Independent modulation of galactese-specific receptor expression in rat liver cells (Massimi et al). 1995;22:1819-28


The integrity of the cholecystokinin receptor gene in gallbladder disease and obesity (Nardone et al). 1995;22:1751- 3

In vivo transfection of hepatitis C virus complementary DNA into rodent liver by asialoglycoprotein receptor medi-


ated gene delivery (Yamamoto et al). 1995;22:847-5

Limited usage of T-cell receptor/3 chains and sequences of the complementarity determining region 3 of lymphocytes infiltrating in the liver of autoimmune hepatitis (Hoshino et al). 1995;22:142-7

Loss of angiotensin-II receptors in portal hypertensive rabbits (Sitzmann et al). 1995;22:559-64



Recombinat ion An open trial of interferon alfa recombi-


Red blood cell carriage Sulfation of acetaminophen by the per-

fused rat liver: the effect of red blood cell carriage (Pang et al). 1995;22:267-82

Regeneration, hepatic Ciprofloxacin prevents the inhibitory ef-

fects of acute ethanol exposure on hepatic regeneration in the rat (Minuk et al). 1995;22:1797-1800

Coexpression of liver-specific and growth- induced genes in perinatal and regenerating liver: attainment and maintenance of the differentiated state during rapid proliferation (Haber et al). 1995;22:906-14

The differential effects of three forms of interferon alfa on hepatic regeneration after partial hepatectomy in the rat (Wong et al). 1995;22:883-6

Differential expression of A and B laminin chains during rat liver regeneration (Gim6nez et al). 1995;22:1259-62


Gene expression of N-acetylglucosaminyltransferases III and IV: a possible im- plication for liver regeneration (Mi- yoshi et al). 1995;22:1847-55

Keratinocyte growth factor-just another mitogen or the "Holy Grail" that regu- lates liver regeneration (Housley et al)? 1995;22:1764-77 (HEPATOL- OGY Elsewhere)

Oval cell differentiation into hepatecytes in the acetylaminofluorene-treated

regenerating rat liver (Golding et al). 1995;22:1243-53



Regulat ion Regulation of gene expression by interleu-

kin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone (Rencero et al). 1995;22:1769-75


Regulatory sequences Hepatoma cell-specific expression of a ret-


Rejection, allograft Does interferon precipitate rejection of

liver allografts (Min and Boden- heimer)? 1995;22:1333-5 (Editorial)

Terminology for hepatic allograft rejection (International Working Party). 1995;22:648-54 (Special article)

Rejection risk An open trial of interferon alfa recombi-

nant for hepatitis C after liver transplantation: antiviral effects and risk of rejection (F6ray eta]). 1995;22:1084-9

Renal effects Renal effects of dietary supplementation

with fish oil in cyclosporine-treated liver transplant recipients (Badala- menti et al). 1995;22:1695-1701

Renal function Long-term effect of nadolol or nadolol plus


Renal perfusion Role of nitric oxide and prostacyclin in the


Ren in Effect of upright posture and physical ex-


Reperfusion injury, hepatic A fish oil diet minimizes hepatic reperfu-


Repertoire The influence of a maternal chronic hepa-


Replication Effect of immunosuppressive and antivi-



Resistance Reversal of atrial natriuretic peptide re-

sistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis (Abraham et al). 1995;22:737-43

Retention Blunted natriuretic response to low-dose


Retrovirally-transferred gene Hepatoma cell-specific expression of a ret-

rovirally transferred gene is achieved by a-feteprotein but not insulinlike growth factor II regulatory sequences (Arbuthnot et al). 1995;22:1788-96

Right heart blood volume, decreased Decreased right heart blood volume deter-

mined by magnetic resonance imaging: evidence of central underfilling in cirrhosis (M011er et al). 1995;22:472-8

Risk reduction Does interferon therapy for chronic hepa-

titis B reduce the risks of developing cirrhosis and hepatocellular carcinoma (Lok). 1995;22:1336-8 (HEPA- TOLOGY Elsewhere)

RNA Detection of hepatitis C virus with RNA

polymerase chain reaction in fulminant hepatic failure (Villamil et al). 1995;22:1379-86

Differential display and integrin alpha 6 messenger RNA overexpression in hepatocellular carcinoma (Begum et al). 1995;22:1447-55


In vivo and in vitro expression of defective

HEPATOLOGY Vol. 22, No, 6, 1995 SUBJECT INDEX 1949




Rodent liver In vivo transfection of hepatitis C virus


Rough endoplasmic reticulum (RER) Organellar clusters formed by mitochon-

drial-rough endeplasmie retieulum associations: an ordered arrangement of mitochondria in hepatocytes (Cas- carano et al). 1995;22:837-46

S

Scintigraphy Parenchymal and nonparenchymal up-

take of technetium-99m, ind ium-I l l , and iodine-125 low-density lipoprotein in the normal and estradiol-stim- ulated rat liver: tracer validation for quantitative low-density lipoprotein scintigraphy (Leitha et al). 1995;22:1289-95

Sclerosing cholangitis Liver transplantation for sclerosing chol-

angitis (Narumi et al). 1995;22:451-7 Sclerotherapy

A prospective, randomized trial of sclerotherapy versus ligation in the management of bleeding esophageal varices (Lo et al). 1995;22:466-71

Screening Efficacy of screening donors for antibodies




Sensitivity induction Induction of sensitivity to ganciclovir in

human hepatocellular carcinoma

cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase (Qian et al). 1995;22:118-23

Sequential production Sequential acetaldehyde production, lipid


Serine proteinase Proteolytic activity of NS3 serine protein-


Seroconversion The significance of spontaneous hepatitis

B e antigen seroconversion in child- hood; with special emphasis on the clearance of hepatitis B e antigen before three years of age (Chang et al). 1995;22:1387-92

Serum Evidence for the presence of an inactive



Phenobarbital modulates the type of cell death by rat hepatocytes during dep- rivation of serum in vitro (Chiao et al). 1995;22:297-303



Serum concentration of intercellular adhesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis (Shimizu et al). 1995;22:525-31

Serum 7a-hydroxycholesterol as a new pa- rameter of liver function in patients with chronic liver diseases (Kuroki et al). 1995;22:1182-7

Sequence analysis Evidence of transmission of hepatitis D


Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by a-fetoprotein but not insulinlike growth factor II regulatory sequences (Arbuthnot et al). 1995;22:1788-96

Limited usage of T-cell receptor/3 chains and sequences of the complementarity determining region 3 of lymphocytes infiltrating in the liver of autoimmune hepatitis (Hoshino et al). 1995;22:142-7

Seven-membrane-spanning receptors Tyrosine kinase growth factor receptors

but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes (Gin, s et al). 1995;22:1296-1303

Sex Effect of donor age and sex on the outcome


Shunts Portal-systemic shunting and portal-sys-

temic encephalopathy: a predictable relationship (Conn). 1995;22:365-6 (HEPATOLOGY Elsewhere)


Sickness behaviors Defective corticotropin-releasing hormone


Sinusoidal cells, hepatic Effects of extracellular matrices on tube


Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2) (Ahmed et al). 1995;22:316-24


Mouse hepatitis virus type 3 infection pro- vokes a decrease in the number of sinusoidal endothelial cell fenestrae both in vivo and in vitro (Steffan et al). 1995;22:395-401

Small hepatocellular carcinoma Pathomorphologic characteristics of small

hepatocellular carcinoma: a special reference to small hepatocellular with indistinct margins (Nakashima et al). 1995;22:101-5

Sodium Blunted natriuretic response to low-dose

brain natriuretic peptide infusion in nonazotemic cirrhotic patients with


ascites and avid sodium retention (La Villa et al). 1995;22:1745-50

Effect of upright posture and physical exercise on endogenous neurohormonal systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldosterone, and norepinephrine levels (Sal5 et al). 1995;22:479-87


Transjugular intrahepatic portosystemic shunt for refractory ascites: tipping the sodium balance (Wong and Blendis). 1995;22:358-65 (Editorial)

Sodium selenite Metabolic effect of sodium selenite: insu-

lin-like inhibition of glucagon-stimu- lated glycogenolysis in the isolated perfused rat liver (Roden et al). 1995;22:169-74

Solitary mass, hepatic A young man with a solitary hepatic mass

(Geders et al). 1995;22:655-9 (Clinico- pathology conferences)

Solubilization Deoxycholic acid influences cholesterol

so]ubilization and microcrystal nucleation time in gallbladder bile (Hus- salni et al). 1995;22:1735-44

Somatostatin Effects of bolus injections and continuous

infusions of somatostatin and placebo in patients with cirrhosis: a double- blind hemodynamic investigation (Cirera et al), 1995;22:106-11

Sonography Cerebral blood flow autoregulation and


Paraumbilical vein patency in cirrhosis: effects on hepatic hemodynamics evaluated by Doppler sonography (Sacerdoti et al). 1995;22:1689-94

South African patients An outbreak of hepatitis A among South

African patients with hemophilia; evidence implicating contaminated factor VIII concentrate as the source (Kedda et al). 1995;22:1363-7

Spl Sp 1 binding activity increases in activated


Spatial expression Proliferation-associated differences in the

spatial and temporal expression of gap junction genes in rat liver (Neveu et al). 1995;22:202-12

Special articles Hepatitis B virus transgenic mice: in-

sights into the virus and the disease (Chisari). 1995;22:1316-25

How to tell the truth and avoid the urge to lie: planning a career in medical research (Sonnenburg). 1995;22:974- 82

The role of transjugular intrahepatic portosystemic shunt for treatment of portal hypertension and its complications: a conference sponsored by the national digestive diseases advisory board (Shiffman et al). 1995;22:1591- 7

Terminology for hepatic allograft rejection (International Working Party). 1995;22:648-54

Terminology of nodular hepatocellular le- sions (International Working Party).1995;22:983-93

Treatment of chronic type B and C hepatitis with interferon alfa: an economic appraisal (Dusheiko and Roberts). 1995;22:1863-73

Specific targeting Specific targeting of adriamycin conju-


Specific targeting of human hepatocellular carcinoma cells by immunolipases in vitro (Moradpour et al). 1995;22:1527-37

Spectroscopy Proton spectroscopy of brain glutamine in


Spleen The liver-spleen scan as a quantitative


Splenic arterial embolization Changes in platelet kinetics after a partial


Splicing In vivo and in vitro expression of defective

hepatitis B virus particles generated by spliced hepatitis B virus RNA (Rosmorduc eta]). 1995;22:10-19

Spontaneous bacterial peritonitis Ciprofloxacin and long-term prevention of

spontaneous bacterial peritonitis: re- suits of a prospective controlled trial (Rolachon et al). 1995;22:1171-4

Spouses Evidence of transmission of hepatitis D


Sprague-Dawley rat Effects of liver transplantation on bile for-

mation and biliary lipid secretion in

the Sprague-Dawley rat (Chan et al). 1995;22:1254-8

Steatosis, hepatic Alterations of peroxisomes in steatosis of


Choline deficiency; a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation (Buchman et al). 1995;22:1399-1403

Steel coils Portal vein embolization with steel coils

and absolute ethanoha comparative experimental study with canine liver (Yamakado et al). 1995;22:1812-8

Stellate cells, hepatic Molecular dissection of the mitogenic ef-

fect of hepatocytes on cultured hepatic stellate cells (Gressner et al). 1995;22:1507-18


Sterol 27-hydroxylase Regulation of bile acid synthesis by deoxy-

cholic acid in the rat: different effects on cholesterol 7a-hydroxylase and sterol 27-hydroxylase (Shefer et al). 1995;22:121

Storage Hepatic sinusoidal endothelial cells can

store and metabolized serum immunoglobulin (Iwamura et al). 1995;22:1456-61

Streaming Experiments in transgenic mice show that


Subcellular distribution Subcellular distribution of large and small

hepatitis delta antigen in hepatocytes of hepatitis delta virus superinfected woodchucks (Cullen et al). 1995;22:1090-I100

Suicide genes Bystander effect caused by suicide gene


Sulfation Sulfation of acetaminophen by the per-

fused rat liver: the effect of red blood cell carriage (Pang et al). 1995;22:267-82

Superinfection Subcellular distribution of large and small

hepatitis delta antigen in hepatocytes of hepatitis delta virus superinfected woodchucks (Cullen et al). 1995;22:1090-1100

Supplementation


Choline deficiency; a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation (Buchman et al). 1995;22:1399-1403


Surgery A comparison of the surgical results in pa-

tients with hepatitis B virus versus hepatitis C-related hepatocellular carcinoma (Takenaka et al). 1995;22: 20-4

Surgery of the liver and biliary tract (Rossi). 1995;22:1616 (Book review)

Survival analysis p53 protein immunoreactivity in extrahe-



Susceptibility An investigation of whether polymor-

phisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population (Chao et al). 1995;22:1409-14

Sustained response Pretreatment serum hepatitis C virus


Synaptosomes Synaptosomal glutamate transport in

thioacetamide-induced hepatic encephalopathy in the rat (Oppong et al). 1995;22:553-8

Syngeneity Cytotoxic activity ofT cells and non-T cells

from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac (Kretz- Remmel and Boelsterli). 1995;22:213- 22

Synthesis Inhibition of nitric oxide synthesis in the


Systemic hypertension Systemic hypertension and diuresis by L-


Systemic perfusion


T

Targeting Specific targeting of adriamycin conju-


Specific targeting of human hepatocetlu- lar carcinoma cells by immunolipases in vitro (Moradpour et al). 1995;22:1527-37

T-cell-mediated autologous hepatotox. icity

T-cell-mediated autologous hepatotoxicity in patients with chronic hepatitis C virus infection (Liaw et al). 1995;22:1368-73

T-cell receptor fl chains Limited usage of T-cell receptor/~ chains


T-cell receptor beta chain variable region genes


T-cells Cytotoxic activity ofT cells and non-T cells

from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to dielofenac (Kretz- Rommel and Boelsterli). 1995;22:213- 22

Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus (Marinos et al). 1995;22:1040-9

Proliferative response of CD4 ÷ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants (L5hr et al). 1995;22:61-8

Technetium-99m Parenchymal and nonparenehymal up-


Temporal expression


Terminology Terminology for hepatic allograft rejection

(International Working Party). 1995;22:648-54 (Special article)

Terminology of nodular hepatoceUular le- sions (International Working Party). 1995;22:983-93 (Special article)

T-helper cells Induction of T-helper cell response to hep-


Therapeutic paracentesis Treatment of patients with cirrhosis and


Thioacetamide Synaptosomal glutamate transport in

thioacetamide-induced hepatic encephalopathy in the rat (Oppong et al). 1995;22:553-8

Three years of age, before The significance of spontaneous hepatitis

B e antigen seroconversion in child- hood; with special emphasis on the clearance of hepatitis B e antigen before three years of age (Chang et al). 1995;22:1387-92

Thrombin Thrombin stimulates proliferation of liver

fat-storing cells and expression of monocyte chemotactic protein-l: potential role in liver injury (Marra et al). 1995;22:780-7

Thymidine kinase Induction of sensitivity to ganciclovir in


Titanium Treatment of patients with cirrhosis and


Total paracentesis Beneficial effects of intravenous albumin


Tracer validation Parenchymal and nonparenchymal up-

take of technetium-99m, indium-i l l , and iodine-125 low-density hpoprotein in the normal and estradiol-stim- ulated rat liver: tracer validation for


quantitative low-density lipoprotein scintigraphy (Leitha et al). 1995;22:1289-95

Transaminases Prevalence of hypertransaminasemia in


Transarterial chemoembolization Hepatic release of erythropoietin induced

by transarterial chemoembolization in patients with hepatocellular carcinoma (Pirisi et al). 1995;22:148-52

Transcranial sonography Cerebral blood flow autoregulation and


Transcription The influence of a maternal chronic hepa-



Transcription factors Differential activation of transcription


Transcytotic vesicular transport Brefeldin A inhibits the transcytotic vesic-


Transfection In vivo transfection of hepatitis C virus


Transferrin Serum carbohydrate-deficient trans-

ferrin; mechanism of increase after chronic alcohol intake (Xin et al). 1995;22:1462-8

Transformation Introduction of a murine p53 mutation

corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation (Dumenco et al). 1995;22:1279-88


Transforming growth factor ~ (TGF-a) Expression of transforming growth factor

alpha in the liver before and after interferon alfa therapy for chronic hepatitis B (Morimitsu et al). 1995;22:1021-6

Intracellular pH regulation in Hep G2 cells: effects of epidermal growth factor, transforming growth factor-a, and insulinlike growth factor-II on Na÷/H ÷ exchange activity (Strazza- bosco et al). 1995;22:588-97

Transforming growth factor m (TGF-~I) Transforming growth factor ~1 increases


Transfusion-associated hepatitis Efficacy of screening donors for antibodies


Transgenic mice Experiments in transgenic mice show that


Hepatitis B virus transgenic mice: in- sights into the virus and the disease (Chisari). 1995;22:1316-25 (Special article)

Transjugular intrahepatic portosystemic shunt (TIPS)


Transjugular intrahepatic portosystemic shunt for refractory ascites: tipping the sodium balance (Wong and Blendis). 1995;22:358-65 (Editorial)

Transjugular intrahepatic portosystemic shunt: is it the ultimate solution for refractory ascites (Wong and Blendis)? 1995;22:1613-15 (HEPA- TOLOGY Elsewhere)

Transmission Evidence of transmission of hepatitis D


Transplantation, liver Aplastic anemia after liver transplanta-

tion (Collins and Klintmalm) (Letter); (Cattral and Langnas) (Reply). 1995;22:1011-12

Can a guest liver bring the gift of a gene to disarm a hostile host (Guha and Chowdhury)? 1995;22:1888-90 (HEP- ATOLOGY Elsewhere)

Cyclosporine and liver transplantation: will the midazolam test make blood

level monitoring obsolete (Watkins)? 1995;22:994-6 (HEPATOLOGY Else- where

Effect of donor age and sex on the outcome of liver transplantation (Marino et al). 1754-62

Effects of liver transplantation on bile formation and biliary lipid secretion in the Sprague-Dawley rat (Chan et al). 1995;22:1254-8

Hepatic distribution of E2 component of pyruvate dehydrogenase complex after transplantation (Neuberger et al). 1995;22:798-801

Liver transplantation for hepatitis C: the promise and the challenge (Di Bisceg- lie). 1995;22:660-2 (Editorial)

Liver transplantation for sclerosing cholangitis (Narumi et al). 1995;22:451-7

An open trial of interferon alfa recombinant for hepatitis C after liver transplantation: antiviral effects and risk of rejection (F6ray et al). 1995;22:1084-9



Transplantation of the liver. Ed. 2 (Koff). 1995;22:1892-3 (Book review)

Transplantation, liver, living-related Donor selection limits use of living-related

liver transplantation (Renz et al). 1995;22:1122-6

Transplantation, liver, orthotopic Hemodynamics after orthotopic liver

transplantation: study of associated factors and long-term effects (Gadano et al). 1995;22:458-65

Transport Brefeldin A inhibits the transcytotic vesic-



In vitro modeling of liver membrane copper transports (Schilsky). 1995;22:1340-2 (HEPATOLOGY Elsewhere)

Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat (Oppong et al). 1995;22:553-8



Transport in the liver (Kof0. 1995;22:1344 (Book review)

Transport proteins Transport proteins and molecular biology:

is cloning the beginning or the end (Stump et al)? 1995;22:669-71 (HEP- ATOLOGY Elsewhere)

Triple hepat i t is virus infection Role of hepatitis C virus in dual and triple

hepatitis virus infection (Liaw). 1995;22:1101-8

Tube formation Effects of extracellular matrices on tube


Tumor grade p53 protein immunoreactivity in extrahe-


Tumor growth The effect of partial hepatectomy on tu-

mor growth in rats: in vivo and in vitro studies (deJong et al). 1995;22:1263-72

Tumor necrosis factor a (TNF-a) Downregulation of phorbol 12-myristate

13-acetate-induced tumor necrosis factor-alpha and interleukin-13 production and gene expression in human monoeytic cells by human alpha- fetoprotein (Wang and Alpert). 1995;22:921-8


Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholic cirrhosis (Le Moine et al). 1995;22:1436-9

Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and medi- ates endotexin-induced cholestasis (Whiting et al). 1995;22:1273-8


Tumors, intrahepatic Specific targeting of adriamycin conju-

gates with monoclonal antibodies to hepatoma associated antigens to intrahepatic tumors in athymie mice (Adler et al). 1995;22:1482-7

2.4G2 monoclonal antibody Fe receptors in liver sinusoidal endothe-

lial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes

and a monoclonal antibody (2.4G2) (Ahmed et al).

Tyrosine kinase growth factor receptors

Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes (Gin, se t al). 1995;22:1296-1303

U

Ulcerat ive cholit is Primary sclerosing cholangitis and ulcera-


Ulcer8 Effect of anti-ulcer drugs on DNA synthe-


Upright posture Effect of upright posture and physical ex-

ercise on endogenous neurohormonal systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldosterone, and norepinephrine levels (SaM et al). 1995;22:479-87

Urban population Screening for hepatocellular carcinoma in

chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North Ameri- can urban population (Sherman et al). 1995;22:432-8

Uridine diphosphate glucuronosyl transferases

Uridine diphosphate glucuronosyl transferases, candidate antigens of liver- kidney microsomal antibodies in hepatitis delta virus-infected patients (Bonino and Brunette) 1995;22:674-6 (HEPATOLOGY Elsewhere)

Uroporphyria, chemical ly induced Ascorbic acid inhibits chemically induced

uroporphyria in aseorbate-reqniring rats (Sinclair et al). 1995;22:565-72

Ursodeoxychol ic acid The combination of ursodeoxycholic acid

and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study (Lindor et al). 1995;22:1158-62


A randomized double-blind, placebo-controlled trial of ursodeosycholic acid in primary biliary cirrhosis (Combos et al). 1995;22:759-66


V

Vaccines Human vaccines and vaccination (Koff).

1995;22:1617-8 (Book review) Variable region genes


Vascular adhesion molecule 1 (VCAM- 1)

Vascular adhesion molecule-1 and intracellular adhesion molecule-1 expression on rat liver cells after lipopoly- saecharide administration in vivo (van Oosten et al). 1995;22:1538

Vascular hyporespons iveness Endothelium-dependent vascular hypore-


Vascular react ivi ty Endothelin and vascular reactivity in cir-

rhosis (Sieber). 1995;22:1609-11 (HEPATOLOGY Elsewhere)

Vasorelaxation Acetylcholine-indueed vasorelaxation in

portal hypertensive rats (Michielsen et al) (Letter); (Jim~nez) (Reply). 1995;22:1009-11

Vein patency Paraumbilical vein patency in cirrhosis:

effects on hepatic hemodynamics evaluated by Doppler sonography (Sacerdoti et al). 1995;22:1689-94

Vesicles Mucin-vesicle interactions in model bile:


Vesicular transport Brefeldin A inhibits the transcytotie vesic-


Viral genome Evidence of transmission of hepatitis D


Viral hepatit is Viral hepatitis and liver disease (Koff).

1995;22:1000 (Book review) Virological features


Virological state The virological and histological states of

anti-hepatitis C virus-positive sub-


jects with normal liver biochemical values (Shindo et al). 1995;22:418-25

Viral replication Integration of hepatitis B virus and alter-


Virological state The virological and histological states of

anti-hepatitis C virus-positive sub- jects with normal liver biochemical values (Shindo et al). 1995;22:418-25

Vitamin E Vitamin E therapy of acute CC14-induced

hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding (Liu et al). 1995;22:1474-81

Vitamins K The growth inhibitory effects of vitamins

K and their actions on gene expression (Wang et al). 1995;22:876-82

W

Whole body e l iminat ion Impaired biliary excretion and whole body


Woodchuck hepatit is virus Inhibition of woodchuck hepatitis virus

replication by adenine arabinoside monophosphate coupled to lactosaminated poly-L-lysine and administered by intramuscular route (Fiume et al). 1995;22:1072-7

Woodchuck lymphocytes In vitro activation of woodchuck lympho-


Women Management of focal nodular hyperplasia


A 28-year old woman with a combined hepatic/cholestatic syndrome (Wurbs et al). 1995;22:1598-1605 (Clinicopa- thology conferences)

Woven mult icompartment capil lary systems


X

X-chromosome Ctonality in hepatocellular carcinoma:


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