NEUROCHEM ISTRY INTERNATIONAL
The Journal for the publication of cellular and molecular aspects of neurochemistry in the form of
original and rapid research communications and also critical reviews and commentaries
Title Section, List of Contents
Author and Subject Index
Volume 23 (1993)
PERGAMON PRESS O x f o r d • N e w Y o r k • S e o u l • T o k y o
NEUROCHE~STRY INTERNATIONAL The Journal for the publication of cellular and molecular aspects of neurochemistry in the form of original and
rapid research communications and also critical reviews and commentaries
Executive Editors
For U.K. A l so for Rev iews , C o m m e n t a r i e s and R a p i d Papers N. N. O s b o r n e ( C h a i r m a n ) : Nuffield Laboratory o f Ophthalmology, University o f Oxfbrd,
Walton Street, Oxford OX2 6A W, U.K.
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L. F. Agnati, Modena T, Bartfai, Stockholm J. G. C. Bockaert, Montpellier J.-M. Bourre, Paris H. Breer, Stuttgart S. H. Buck, Tucson, AZ R. D. Burgoyne, Liverpool, U.K. A. P. Carvalho, Coimbra M. Ebadi, Omaha, NE M. Fillenz, Oxford, U.K. R. W. Fuller, Indianapolis, IN K. G. Fuxe, Stockholm M. Hadjiconstantinou, Columbus, OH M. Hamon, Paris R. J. Huxtable, Tucson, AZ P. M. Iuvone, Atlanta, GA D. M. Jacobowitz, Bethesda, MD G. Jaim-Etcheverry, Buenos Aires
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Editorial Advisorv Board B. Jarrot t , Clayton, Victoria G. Kapatos, Detroit, MI J. E. Krause, St Louis, MO D. M. Kuhn, Detroit,/VII P. J. Magistretti, Lausanne M. H. Makman, New York, NY N. Miki, Osaka N. Morel, Gif-sur-Yvette A. H. Muider, Amsterdam T. Nagatsu, Nagoya D. G. Nicholls, Dundee, U.K. B. Oderfeid-Nowak, Warsaw S. E. Poduslo, Lubbock, TX J. F. Pujol, Lyon M. Raiteri, Genoa T. A. Reader, Montrbal M. Recasens, Montpellier P. J. Richardson, Cambridge, U, K.
S. Rose, Milton Keynes, U.K. R. H. Roth, New Haven, CT E. Sanders-Bush, Nashville. TN A. Schousboe, Copenhagen J. P. Schwartz, Bethesda, MD R. Tanaka, Nagoya V. I. Teichberg, Rehovot G. Tettamanti, Milan G. Toffano, Abano Terme K. Uyemura, Tokyo J.-J. Vanderhaeghen, Brussels G. Vauquelin, Sint Genesius-Rode E. S. Vizi, Budapest G. P. Wiikin, London, U.K J.-Y. Wu, Lawrence, KS H. Zimmermann, Frankfurt am Main
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Number 1
Jean-Antoine Girault
Fabio Benfenati and Flavia Valtorta
Rosemarie Brett and Martin G. Rumsby
A. Muralikrishna Rao, Urule Igbavboa, Michael Semotuk, Friedhelm Schroeder and W. Gibson Wood
Wan-Wan Lin and De-Maw Chuang
J. D. Elsworth, J. R. Taylor, P. Berger and R. H. Roth
Kotaro Shimoda, Gregory H. Shen, Ronald F. Pfeiffer, Rodney D. McComb and Hsiu-Ying T. Yang
Eva Czerwiec, Jean-Paul de Backer, Werner de Potter and Georges Vauquelin
John A. Murphy, Rebecca Turner and Martin G. Rumsby
LIST OF C O N T E N T S
VOLUME 23 (1993)
27
35
45
53
61
71
Invited Review: Protein phosphorylation and dephosphorylation in mammalian central nervous system
Critique: Protein phosphorylation in the nerve terminal
Evidence of free radical damage in the central nervous system of guinea- pigs at the prolonged acute and early relapse stages of chronic relapsing experimental allergic encephalomyelitis
Kinetics and size of cholesterol lateral domains in synaptosomal membranes: modification by sphingomyelinase and effects on membrane enzyme activity
Agonist-induced desensitization of ATP receptor-mediated phos- phoinositide turnover in C6 glioma cells: comparison with the negative- feedback regulation by protein kinase C
Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum
Antiserum against neuropeptide Y enhances the nicotine-mediated release of catecholamines from cultured rat adrenal chromaffin cells
79
87
Selective masking of Ml-receptors in calf retina membranes by the venom of the marine snail Conus tessulatus
The protein kinase C, calcium-independent and calcium-dependent kinase activities of glial cells in primary culture and subculture
95 Book Review
97 News Items
Number 2
Ashok Kumar and Reinhard Schliebs
Yoshio Tokuda, Tohru Uozumi and Takashi Kawasaki
Stephen James and Peter J. Richardson
D. Maysinger, P. Piceardo, J. Filipovic-Grcic and A. C. Cuello
Dorothy K. Leong, Peter R. Dodd and Graham A. R. Johnston
99
107
Postnatal ontogeny of GABA~ and benzodiazepine receptors in individual layers of rat visual cortex and the effect of visual deprivation
The superoxide dismutase activities of cerebral tissues, assayed by the chemiluminescence method, in the gerbil focal ischemia/reperfusion and global isehemia models
115 The subcellular distribution of [3H]-CGS 21680 binding sites in the rat striatum: copurification with cholinergic nerve terminals
123 Microencapsulation of genetically engineered fibroblasts secreting nerve growth factor
131 Brain extracts containing a Huntington disease antigen inhibit [3H]kainate binding and block synaptosomal amino acid transport
iii
iv
Michele Zoli, Emilio Merlo Pich, Francesco Ferraguti, Giuseppe Biagini, Kjell Fuxe and Luigi F. Agnati
Yutaka Koyama, Tadashi lshibashi, Heitaroh Iwata and Akemichi Baba
139
149
G. Lupo, C. D. Anfuso and M. Alberghina 157
Sahebarao P. Mahadik, Basalingappa L. Hungund, Vinayak S. Gokhale, Astrid Ortiz, Tapas K. Makar and Stephen E. Karpiak
H. G. E. Lloyd, K. Lindstr6m and B. B. Fredholm
Li Hsueh Tsai, Wuhong Tsai and Jang-Yen Wu
163
173
hldcx
Indole-pyruvic acid treatment reduces damage in striatum but not in hippocampus after transient forebrain ischemia in the rat
Pretreatment of rat brain slices with ouabain decreases chloride- dependent L-glutamate transport in synaptic membrane
Aging does not affect the susceptibility to lipid peroxidation and lyso- somal enzyme release of rat visual system structures and sciatic nerve
Monosialoganglioside (GMI) restores membrane fatty acid levels in ischemic tissue after cortical focal ischemia in rat
lntracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion
187 Action ofmyenteric GABAergic neurons in the guinea pig stomach
195 News Items
Number 3
Sudhir Paul and Manuchair Ebadi
Sami I. Said
197
David R. Bolin
215
M. Alberghina, G. Lupo and C. D. Anfuso
Kohtaro Takei, Kunio Kitamura, Koji Banno and Keiichi Uyemura
A. M. Cimini, S. Moreno, M. Giorgi, B. Serafini and M. P. Certi
Marek Samochoeki and Joanna Strosznajder
D. Becquet, M. Hery, A. M. Francois-Bellan, P. Giraud, P. Deprez, M. Faudon, M. P. Fache and F. Hery
A. Gorodinsky, Y. Paas and V. I. Teichberg
221
229
239
invited Review: Vasoactive intestinal peptide: its interactions with calmodulin and catalytic antibodies
Critique: Vasoactive intestinal peptide: involvement of calmodulin and catalytic antibodies
Critique: Vasoactive intestinal peptide: role ofcalmodulin and catalytic antibodies
Lipid peroxidation inhibits oleoyl-CoA: 1-acyl-sn-glycero-3-phospho- choline O-acyltransferase in rat CNS axolemma-enriched fractions
Major glycoproteins in carp CNS myelin: homology to P0 protein with HNK-I/L2 carbohydrate epitope
249 Purification of peroxisomal fraction from rat brain
261
269
285
Modulatory action of arachidonic acid on GABAA/Chloride channel receptor function in adult and aged brain cortex membranes
Glutamate, GABA, glycine and taurine modulate serotonin synthesis and release in rostral and caudal rhombeneephalic raphe cells in primary cultures
A ligand binding study of the interactions of guanine nucleotides with non-NMDA receptors
293 Book Reviews
295 News Items
Number 4
Paul Bach-y-Rita
Tsutomu Araki, Fumie Murakami, Yasuo Kanai, Hiroyuki Kato and Kyuya Kogure
Nobutaka Motohashi, Yasumasa Okamoto, Masashi Osada and Shigeto Yamawaki
Erwin Tareilus, Juergen Schoch, Michael Adams and Heinz Breer
Jef Pinxteren, Marlene Jimenez Del Rio, Carlos Velez Pardo, Guy Ebinger, Georges Vauquelin and Wemer De Potter
A. Takada, M. Grdi~a, M. Diksic, A. Gjedde and Y. L. Yamamoto
Sui-Po Zhang, Long-Wu Zhou, Naoki Natsukari and Benjamin Weiss
Donald R. Gehlert, Douglas A. Schober, Susan L. Gackenheimer, Dale E. Mais, Gaetan Ladouceur and David W. Robertson
Danica B. Stanimirovic, Fatima Bacic, Sumio Uematsu and Maria Spatz
Index v
297
319
Commentary: Nonsynaptic diffusion neurotransmission (NDN) in the brain
Naloxone receptor binding in gerbil striatum and hippocampus follow- ing transient cerebral ischemia
327 Acute swim stress increases benzodiazepine receptors, but not GABAA or GABAB receptors, in the rat cerebral cortex
331 Analysis of rapid calcium signals in synaptosomes
343 Soluble serotonin and catecholamine binding proteins in the bovine adrenal medulla
351
361
373
Rapid steady-state analysis of blood-brain transfer of L-Trp in rat, with special reference to the plasma protein binding
Continuously infusing quinpirole decreases Ca2+/calmodulin-dependent phosphorylation in mouse striatum
Synthesis and evaluation of [~2~I]-(S)-iodozacopride, a high affinity radioligand for 5HT3 receptors
385 Profileofprostaglandinsinducedbyendothelin-1 inhumanbraincapillary endothelium
395 Book Reviews
397 News Items
Number 5
Toshiaki Iino, Masashi Katsura and Kinya Kuriyama
Brian Pearce and Sean Murphy
S. E. Poduslo, P. Decker, H. Astle, J. Kurth and M. LaBate
Sylvain Bartolami, Myriam Planche and R6my Pujol
Takeo Suzuki, Kiyokazu Ogita and Yukio Yoneda
Keith J. Brooks and Risto A. Kauppinen
Raman Pal, Ravindra Nath and Kiran Dip Gill
399 Effect of vinconate, an indolonaphthyridine derivative, on metabolism and function of cerebral cholinergic neurons in rat
407 Protein kinase C down-regulation in astrocytes: differential effects on agonist-stimulated inositol phosphate accumulation
413 Identification of a new polymorphism in the human proteolipid protein gene
419 Characterization of muscarinic binding sites in the adult and developing rat cochlea
427 Potentiation by polyamines of an interaction of noncompetitive antagonists at the N-methyl-D-aspartate receptor ionophore complex with phosphatidylserine
441 Calcium-mediated damage following hypoxia in cerebral cortex e x v i v o
studied by NMR spectroscopy. Evidence for direct involvement of voltage-gated Ca2--channels
451 Influence of ethanol on cadmium accumulation and its impact on lipid peroxidation and membrane bound functional enzymes (Na +, K +- ATPase and acetylcholinesterase) in various regions of adult rat brain
German A. Roth, Marcelo D. Gonzalez, Clara G. Monferran, Marta L. De Santis and Federico A. Cumar
Susan K. Hemrick-Luecke, Charles H. Mitch, Stephen J. Quimby and Ray W. Fuller
Jackson MOiler, Joao B. T. Rocha, Ana M. O. Battastini, Jo~o J. F. Sarkis and Renato D. Dias
C. Ghosh, R. M. Dick and S. F. All
Xiao Wen Tang, Mina Yarom, Robert G. Carlson, David Vander Velde, Po Yu Huang, Yi-Hsuan Lee, Ee-Ching Seah, David Deupree and Jang-Yen Wu
Index
459 Myelin basic protein domains involved in the interaction with actin
467
471
Effect of 4-(4-methoxy-l,2,5-thiadiazol-3-yl)-l-methyl-l,2,3,6-tetra- hydropyridine, an analog of MPTP, on mouse heart norepinephrine and brain catecholamines
Postnatal development of ATPase-ADPase activities in synaptosomal fraction from cerebral cortex of rats
479 lron/ascorbate-induced lipid peroxidation changes membrane fluidity and muscarinic cholinergic receptor binding in rat frontal cortex
485 Isolation of endogenous modulators for the GABAA and taurine receptors
495 Book Reviews
497 News Items
Number 6
Ferenc Jo6
Berislav V. Zlokovic
G. Brochier and N. Morel
Tsutomu Araki, Hiroyuki Kato, Yasuo Kanai and Kyuya Kogure
L. Leger, A. Cupo, Y. Charnay, K. Cucumel and M. Jouvet
M. Simonato, G. Bregola, A. Muzzolini, C. Bianchi and L. Beani
H. Shiraga, R. F. Pfeiffer and M. Ebadi
O. Bourde, P. Schmitt, F. Robert, F. Richard, A.-C. Carbonnele, C. Thai and J. F. Pujol S. Wang, F. M. Longo, J. Chen, M. Butman, S. H. Graham, K. G. Haglid and F. R. Sharp
Victor B. Cockcroft, Marcelo O. Ortells, Philip Thomas and George G. Lunt
499
523
525
541
549
555
561
567
575
Invited Review: The blood-brain barrier in vitro: the second decade
Critique: The blood-brain barrier in vitro: recent progress
The same 15 kDa proteolipid subunit is a constituent of two different proteins in Torpedo, the acetylcholine releasing protein mediatophore and the vacuolar H+ATPase
Selective changes of neurotransmitter receptors in middle-aged gerbil brain
Chromatographic analysis of the enkephalin immunoreactivity in the nucleus locus coeruleus of the cat after local colchicine administration
Characterization of K ~-evoked [3H]D-aspartate outflow in the rat hippo- campus in vitro
The effects of 6-hydroxydopamine and oxidative stress on the level of brain metallothionein
Long term effect of RU24722 on tyrosine hydroxylase in the rat locus coeruleus: differential effects of two enantiomeric forms
Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia
583 Homologies and disparities of Glutamate receptors: a critical analysis
595 Book Reviews
597 News Items
Adams M., 331 Agnati L.F., 139 Alberghina M., 157, 229 Ali S. F., 479 Anfuso C. D., 157, 229 Araki T., 319, 541 Astle H., 413
Baba A., 149 Bach-y-Rita P., 297 Bacic F., 385 de Backer J-P., 79 Banno K., 239 Bartolami S., 419 Battastini A. M. O., 471 Beani L., 555 Becquet D., 269 Benfenati F., 27 Berger P., 61 Biagini G., 139 Bienchi C., 555 Bolin D. R., 221 Bourde O., 567 Bree~ H., 331 Bregola G., 555 Brett R., 35 Brochier G., 525 Brooks K. J., 441 Butman M., 575
Carbonnele A-C., 567 Carlson R. G., 485 Cer6 M. P., 249 Charnay Y., 549 Chen J., 575 Cimini A. M., 249 Cockcroft V. B., 583 Cuello A.C., 123 Cumar F. A., 459 Cumcumel K., 549 Cupo A., 549 Czerwiec E., 79
De Santis M. L., 459 De-Maw Chuang., 53
A U T H O R I N D E X
Decker P., 413 Del Rio M.J., 343 Deprez P., 269 Deupree D., 485 Dies R. D., 471 Dick R.M., 479 Diksic M., 351 Dodd P. R., 131
Ebadi M., 197, 561 Ebinger G., 343 Ee-Ching Seah., 485 Elsworth J. D., 61
Fache M. P., 269 Faudon M., 269 Ferraguti F., 139 Filipovic-Grcic J., 123 Francois-Bellan A. M., 269 Fredholm B. B., 173 Fuller R. W., 467 Fuxe K., 139
Gackenheimer S. L., 373 Gehlert D. R., 373 Ghosh C., 479 Gill K. D, 451 Giorgi M., 249 Giraud P., 269 Girault J-A., 1 Gjedde A., 351 Gokhale V. S., 163 Gonzalez M. D., 459 Gorodinsky A., 285 Graham S. H., 575 Grdi[a M., 351
Haglid K. G., 575 Hemrick-Luecke S. K., 467 Hery F., 269 Hery M., 269 Hsiu-Ying T. Yang., 71 Hungund B. L., 163
Igbavboa U., 45
Iino T., 399 Ishibeshi T., 149 Iwata H., 149
James S., 115 Jan 8- Yen Wu 187, 485 Johnston G. A.R., 131 Jo6 F., 499 Jouvet M., 549
Kanai Y., 319, 541 Karpiak S. E., 163 Kato H., 319, 541 Katsura M., 399 Kauppinen R. A., 441 Kawesaki T., 107 Kitamura K., 239 Kogure K., 319, 541 Koyama Y., 149 Kumar A., 99 Kuriyama K., 399 Kurth J., 413
LaBate M., 413 Ladouceur G., 373 Leger L., 549 Leong D. K., 131 Li Hsueh Tsai., 187 Lindstr6m K., 173 Lloyd H. G.E., 173 Long-Wu Zhou., 361 Longo F. M., 575 Lunt G. G., 583 Lupo G., 157, 229
Mahadik S. P., 163 Mais D. E., 373 MakarT. K., 163 Maysinger D., 123 McComb R. D., 71 Milch C. H., 467 Monferran C. G., 459 Morel N., 525 Moreno S., 249
vii
Index
Motohashi N., 327 Mtlller J., 471 Murakami F., 319 Murphy J. A., 87 Murphy S., 407 Muzzolini A., 555
Nath R., 451 Natsukari N., 361
Ogita K., 427 Oktmoto Y., 327 Orteiht M. O., 583 Ortiz A., 163 Osada M., 327
P u s Y., 285 Pal R., 451 Pardo C.V., 343 Paul S., 197 Pearce B., 407 Pfeiffer R. F., 71,561 Piccardo P., 123 Pich E.M., 139 Pinxteren J., 343 Planehe M., 419 Po Yu Huan$., 485 Poduslo S. E., 413 de Potter W., 79, 343 Pujol J. F., 567 Pujol R., 419
Quimby S. J., 467
Rao A. M., 45 Richard F., 567 Richardson P.J., 115 Robert F., 567 Robertson D. W., 373 Rocha J. B. T., 471 Roth G. A., 459 Roth R. H., 61 Rumsby M. G., 35, 87
Said S. I., 215 Samochocki M., 261 Sarkis J. J. F., 471 Schliebs R., 99 Schmitt P.0 567 Schober D. A., 373 Schoch J., 331 Schroeder F., 45 Semotuk M., 45 Serafini B., 249 Sharp F. R., 575 Shen G. H., 71 Shimoda K., 71 Shiraga H., 561 Simonato M., 555 Spatz M., 385 Stanimirovic D. B., 385 Strosznajder J., 261 Sui-Po Zhang., 361 Suzuki T., 427
Takada A., 351 Takei K., 239 Tareilus E., 331 Taylor J. R., 61 Teichberg V. I., 285 Thal C., 567 Thomas P., 583 Tokuda Y., 107 Turner R., 87
Uematsu S., 385 Uozumi T., 107 Uyemura K., 239
Valmrta F., 27 Vander Velde D., 485 Vauquelin G., 79, 343
Wan-Wan Lin., 53 Wang S., 575 Weiss B., 361 Wood W. G., 45 Wuhong Tsai., 187
Xiao Wen Tang., 485
Yamamoto Y. L., 351 Yamawaki S., 327 Yarom M., 485 Yi-Hsuan Lee., 485 Yoneda Y., 427
Zlokovic B. V., 523 Zoli M., 139
viii
SUBJECT INDEX
N-acetyl aspartate - in hypoxia, 441 acetylation - of lysophosphatidylcholine, 229 acetylcholine content - in rat brain, 400 acetylcholine release - effect of sulpiride, 400 acetylcholine releasing protein - mediatophore, 525 acetylcholinesterase - in rat brain, 400
- influence of ethanol and cadmium, 451 actin - interaction with myelin basic protein, 459 adenosine release - by anoxia, 173 adenosine - formation in hippocampus, 173
- release from hippocampus, 173 ATPase activity - in synaptosomes, 471 adrenal chromaffin cells - release of catecholamines, 71 adrenal medulla - serotonin and catecholamine binding proteins, 343 age related changes - of receptors, 541
- of voltage dependent calcium channels, 541 aging - lipid peroxidation not altered, 157
- release of lysosomal enzyme not altered, 157 allergic encephalomyelitis - free radical damage, 35 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate - see AMPA ct. receptors - present on striatai cholinergic neurones, 115
,ca 3 o~2a-selective ligand - H-CGS 21680, 115 amino acid transport - in synaptosomes, 131 3H-amino acid transport - reduced by antigen from Huntington disease, 131 3H-AMPA binding - interactions with guanine nucleotides, 285 anoxia - release of adenosine, 173 antibodies - interaction with vasoactive intestinal peptide, 197 arachidonic acid - modulation of GABA A/chloride channel receptor, 261 ARPP- 16, 15 ARPP-21, 15 ascorbate - and lipid peroxidation, 479 aspartate - K+-induced release from hippocampus, 555 astrocytes - agonist stimulation of inositol phosphates, 407
- PKC, 407 ATP action on phosphoinositide turnover - effect of PKC activation, 53 ATP - effect on phosphoinositide turnover, 53
- in hypoxia, 441 - stimulates inositol phosphates accumulation, 53
ATPase activity - in synaptosomes, 471 autoantibodies - to vasoactive intestinal peptide, 204, 222 autoradiography - of 125I-(S)-iodozacopride binding, 373
3H-baclofen binding - to cerebral cortex, 327 benzodiazepine receptors - increase with swim stress, 327
- postnatal ontogeny, 99 binding proteins - to serotonin and catecholamines, 343 blood-brain harrier, 499
- recent progress, 523 blood-brain transfer of tryptophan, 351 35[S]-t-butylbicyclophosphorothionate - binding to synaptic membranes, 261
C~ glioma cells - phosphoinositide turnover, 53 ca-dmium accumulation - effect of calcium, 451 calcium signals - in synaptosomes, 331 calcium - involvement in VIP action, 215 calcium/phospholipid-dependent PKC - in glial cells, 87 calcium-dependent PKC - in glial cells, 87
ix
x Subject Index
ca lc ium-independent P K C - in glial cells, 87 ca lc ium-media ted damage - in hypoxia, 441 ca lc ium/calmodul in-dependent phosphorylat ion - decreased by quinpirote, 361 calmodulin - interaction with vasoactive intestinal peptide, 197 c A M P levels - in synaptosomes, 331 c A M P - involvement in VIP action, 215 catalytic antibodies - interaction with vasoactive intestinal peptide, 197 catecholamine binding proteins - in adrenal medulla, 343 catecholamine release - enhanced by nicotine, 71 catecholamines - effect o f MPTP and MZPT, 467
- released from adrenal chromaff in cells, 71 cerebral microvessels , 499 c G M P - factors influencing formation in microvessels , 506 3H-CGS 21680 - binding associated with acetylcholinesterase, 115
- binding o f the A~ -selective ligand, 115 channels - phosphorylat ion, ~a chemi luminescence method - for superoxide dismutase, 107 chlor ide-dependent glutamate transport - effect o f glutamate, 149 cholesterol domains , 45 cholesterol pools - effect o f the hydrolysis o f sphingomyelin, 45 cholesterol - in synaptosomal membranes , 45 choline acetyltransferase - in rat brain, 400 cholinergic markers - o f different brain areas, 529 cholinergic neurones - presence o f A. receptors, 115
- effect o f vinconate, 39~ chromatographic analysis - o f enkephal in immunoreactivity, 549 cocaine-insensi t ive - dopamine uptake, 61 cocaine-sensi t ive - dopamine uptake, 61 cochlea - muscarinic receptors, 419 coexistence - o f VIP with other transmitters, 216 colchicine - effect on enkephalin immunoreactivity, 549 Conus tessulatus venum - selectively maskes Ml- recep tors , 79 cortical membranes - binding o f muscimol and flunitrazepam, 100
DARPP-32, 13 DARPP-32 immunoreact ivi ty - effect o f ischemic insults, 139 diamine systems in the brain, 303 dopamine neurones - protein phosphorylat ion, 12 dopamine receptors - effect o f quinpirole, 361 dopamine uptake - cocaine sensitive and insensitive, 61
endothelial cells - o f microvesssels , 499 endothelin- 1 - st imulation o f prostaglandins, 385
- stimulation o f prostanoids, 385 endothel ium - formation o f prostaglandins, 385 enkephalin immunoreact ivi ty - in nucleus locus coeruleus o f the cat, 549
- influence o f colchicine, 549 enzymes - associated with peroxisomes, 249 ethanol - effect on cadmium accumulation, 451
fatty acid levels in membranes - restored by GM1, 163 - reduced fol lowing ischaemia, 163
3H-fenflunitrazepam binding, 485 fibroblasts - genetically engineered to secrete NGF, 123 3H-flunitrazepam binding - to cerebral cortex, 327
- to cortical membranes , 100 free radical damage - in allergic encephalomyeli t is , 35
G A B A receptors - not altered in cortex after swim stress, 327 G A B A - modulat ion o f serotonin synthesis and release, 269
- physiological effects on stomach muscle, 187 G A B A A receptors - in s tomach, 187
- isolation o f endogenous modulators, 485 - postnatal ontogeny, 99
Subject Index xi
GABAA/Chloride channel receptor - in adult and aged rats, 261 - modulation by arachidonic acid, 261
GABAergic neurones - in stomach, 187 genetically engineered fibroblasts, 123 gerbil - global ischaemia, 107 glial cells - PKC, 87 glial - neuronal communication, 302 global ischemia - in gerbil, 107 ~HlUCose regulated protein (grp78) nRNA - in seizures and ischaemia, 575
-glutamate binding, 485 glutamate receptors - pharmaoology, 591
- homologies and disparities, 583 glutamate transport - effect of ouabaln, 149
- in synaptic membrane, 149 glutamate - in hypoxia, 441 glycine - modulation of serotonin synthesis and release, 269 glycoprotein - PO-like in nature, 239 GM1 - see monosialoganglioside growth factors - receptors, 12 growth hormone releasing factor - receptors, 197, 222 guanine nucleotides - interaction with binding of 3H-AMPA and 3H-kainate, 285
heat shock protein (hsp70) mRNA - in seizures and ischaemia, 575 hippocampus - release of aspartate, 555
- synaptosomes, 556 HNK-l /L2 carbohydrate epitope - and PO-like glycoprotein in carp brian, 239 Huntington disease - an antigen reduces amino acid transport, 131 Huntington disease - an antigen reduces kainate binding, 131 5-HT3.receptors - binding of 125I-(S)-iodozacopride, 373 hypoxxa - calcium-mediated damage, 441
- metabolism monitored by NMR, 441 6-hyroxydopamine - effect on brain metallothionein, 561
indole-pyruvic acid - converted to kynurenic acid, 139 - reduces ischaemic damage, 139
inositol phosphates - stimulated by ATP, 53 - stimulation in asctrocytes, 407
inositol trisphosphate - levels in synaptosomes, 331 125I-(S)-iodozacopride - binding to 5-HT 3 receptors, 373 iron - and lipid peroxidation, 479 ischaemia - JH-nalaxone binding in striatum and hippocampus, 319
- effect on grp78 and hsp70 mRNAs, 575 - effect on learning, motor tests and DARPP-32, 139
ischaemia/reperfusion - effect on superoxide dismutase, 107 ischaemic damage - ,'educed by indole-pyruvic acid, 139 ischaemic tissue - membrane fatty acid levels reduced, 163
3H-kainate binding - in synaptosomes, 131 - inhibited by an antigen from Huntington disease, 131 - interactions with guanine nucleotides, 285
kainic acid-induced seizures, 575 kynurenic acid - formed from indole-pyruvic acid, 139
lactate - in hypoxia, 441 lipid peroxidation - influence of ethanol and cadmium, 451
- influence of iron/ascorbate, 479 - not affected in aging, 157
locus coeruleus - tyrosine hydroxylase activity, 567 long term potentiation, 306 lysophosphatidylcholine - peroxidation and acetylation, 229 lysosomal enzyme release - not affected in aging, 157
M l-receptors - selectively masked, 79 mediatophore - a lipoprotein, 525
- an acetylcholine releasing protein, 525 membrane fatty acids - reduced following ischaemia, 163
xii Subject Index
membrane fluidity, 479 metallothionein - effect of 6-hydroxydopamine or oxidative stress, 561
- in brain, 451 microvessels - cGMP, 506
- molecular biology, 509 - of the cerebrum, 499 - pathophysiology, 510
MK-801 - interaction with phosphatidylserine for NMDA receptor, 427 modulators - endogenous forms for GABA A and taurine receptors, 485 molecular biology - of brain microvessets, 509 monoamine systems in the brain, 303 monosialoganglioside (GM 1) - restores fatty acid levels, 163 motor tests - effect ofischaemia, 139 MPTP - effect on catecholamines, 467 muscarinic binding - in cochlea, 419 muscarinic Ml-receptors - in retina, 79 muscarinic receptors, 479 muscimol binding inhibitor, 485 3H-muscimol binding, 485
- to cerebral cortex, 327 - to cortical membranes, 100 - to synaptic membranes, 261
myelin basic protein -interaction with actin, 459 MZTP - effect on catecholamines, 467
3H-nalaxone binding - following iscbaemia, 319 to striatum and hippocampus, 319
nerve growth factor - released from fibroblasts, 123 neuromodulation, 301 ,qeuronal communication - role of glia, 302 neuronal cultures - of raphe cells, 269 neuropeptide Y antiserum - enhances catecholamine release, 71 nicotine - enhances catecholamine release, 71 nicotine-mediated catecholamine release - enhanced by NPY antiserum, 71 nitric oxide, 305 NMDA receptors - interactions of MK-801 and phosphatidylserine, 427 NMR - of brain components, 485
used to monitor metabolism in hypoxia, 441 nonsynaptic diffusion transmission, 297 nuclear magnetic resonance = NMR
ontogeny - of benzodiazepine and GABA A receptors, 99 ouabain - decreases chloride-dependent gIfitamate transport, 149
- effect on glutamate transport, 149 oxidative stress - effect upon metallothionein, 561
pathophysiology - of brain microvessels, 510 peroxidation - of lysophosphatidytcholine, 229 peroxisomes - enzyme activities, 249
purification from rat brain, 249 pH - intracellular levels in hypoxia, 441 phosphatidylserine - interaction with MK-801 for NMDA receptor, 427 phospbocreatine - in bypoxia, 441 phosphoinositide turnover - effect of ATP, 53
in C. glioma cells 53 phosphoinositides - involvement m VIP actaon, 215 phosphoprotein phosphatases, 6 phosphoproteins - presynaptic membranes, 30
synaptic vesicles, 27 phosphorylation - influence of quinpirole, 361
- of dopamine neurones, 12 regulation of ion channels, 9
3H-pirenzepine binding - to retinal membranes, 82 PKC - down regulation in astrocytes, 407 plasma proteins - binding of tryptophan, 351 plymerase chain reaction - identification of proteolipid protein, 413
Subject Index xiii
polymorphism -in gene for proteolipid protein, 413 postnatal development - of ATPase/ADPase activities, 471 potassium-induced release of aspartate, 555 PO-like glycoprotein - in carp brain, 239
- similarity to HNK-1/L2 carbohydrate epitope, 239 presynaptic membrane - phosphoproteins, 30 prostaglandin formation - in capillary endothelium, 385 prostaglandins - effect of endothelin-1,385 prostanoids - effect of endothelin- 1,385
- formed in endothelium, 385 protein dephosphorylation, 1 protein kinase C - involved in desensitization of ATP effect, 53 protein kinase C - see PKC protein kinase inhibitors, 5 protein kinases - classification, 2
- structure, 3 protein phosphorylation, 1
- in cerebral endothelium, 507 proteolipid protein gene, 413 .proteolipid - of 15 KDal identified as a subunit of mediatophore, 525
3H-QNB - binding, 479 - in cochlea, 419 - to retinal membranes, 81
quinpirole - decreases calcium/calmodulin-dependent phosphorylation, 361 - effect on dopamine receptors, 361
raphe primary neuronal cultures, 269 receptor plasticity, 302 receptors - age related changes, 541
- for growth factors, 12 - of neurotransmitters in gerbil brain, 541
receptor-coupled - responses in astrocytes, 407 retina - M 1-receptors, 79 retinal membranes - binding of muscarinic ligands, 81 RU24722 - effect on tyrosine hydroxylase, 567 RU24722 = vindeburnol
seizures - effect on grp78 and hsp70 mRNAs, 575 - induced by kainic acid, 575
serine/threonine kinases, 3 serine/threonine/tyrosine kinases, 3 serotonin binding proteins - in adrenal medulla, 343 serotonin release - modulation by GABA, glycine and taurine, 269 serotonin synthesis - modulation by GABA, glycine and taurine, 269 sodium/potassium ATPase - influence of ethanol and cadmium, 451 sphingomyelin - hydrolysis, 45
- hydrolysis on cholesterol pools, 45 stress - increases benzodiazepine receptors, 327 sulpiride - effect on acetylcholine release, 400 superoxide dismutase - activities in ischaemia insulted tissues, 107
- chemiluminescence method, 107 synapsins, 28 synaptic membranes - binding of ligands to GABAA/chloride channel, 261
- glutamate transport, 149 synaptic vesicles - phosphoproteins, 27 synaptophysins, 29 synaptosomal membranes - cholesterol, 45 synaptosomes - ATPase and ADPase activities, 471
- calcium signals, cAMP and inositol trisphosphate levels, 331 - of hippocampus, 556
synaptotagmin, 29
taurine binding, 485 3H taurine receptors -isolation of endogenous modulators, 485 taurine - modulation of serotonin synthesis and release, 269
xiv Subject Index
transient cerebral i schaemia - in geril, 319 tryptophan - binding to plasma proteins, 351 tyrosine hydroxylase - effect o f RU24722, 567
- in locus coeruleus, 567 tyrosine kinases, 3
vacuolar type H+ATPase, 525 vasoactive intestinal peptide - autoantibodies, 204, 222
- coexis tence with other transmitters, 216 - functions, 216 - receptors, 197 - second messengers , 215 - structure, 197, 222 - interactions with calmodulin and antibodies, 197
venum o f Conus tessulatus - selectively masks Ml- recep tors , 79 vinconate - ef fect on cholinergic neurones, 399 vindeburnol - see RU24722 V I P - see vasoactive intestinal pept ide visual cortical layers - benzodiazepine and GABAArecep to r s , 99 voltage dependent calcium channels - age related 6hanges, 541
water t-maze learning - effect o f ischaemia, 139
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