User Guide - SRTR€¦ · St. Luke's Medical Center (WISL). The report has three main sections: A....

Aurora St. Luke's Medical CenterCenter Code: WISLTransplant Program (Organ): KidneyRelease Date: October 9, 2018Based on Data Available: July 31, 2018

SRTR Program-Specific ReportFeedback?: [email protected] (7787)http://www.srtr.org

The data reported here were prepared by the Scientific Registry of Transplant Recipients (SRTR)under contract with the Health Resources and Services Administration (HRSA). Page: i

User Guide

This report contains a wide range of useful information about the kidney transplant program at AuroraSt. Luke's Medical Center (WISL). The report has three main sections:

A. Program SummaryB. Waiting List InformationC. Transplant Information

The Program Summary is a one-page summary highlighting characteristics of the program, includingthe number of candidates on the waiting list, the number of transplants performed at the program, thenumber of patients being cared for by the program, and patient outcomes, including outcomes while onthe waiting list (the transplant rate and the death rate while on the waiting list) and outcomes aftertransplant (patient and graft survival probabilities). If the program performed transplants in both adultsand children, survival probabilities for adults and children (pediatrics) are provided separately. For eachof the outcomes measures presented, a comparison is provided showing what would be expected atthis program if it were performing as similar programs around the country perform when treating similarpatients. More details regarding these outcome measures are provided in Sections B and C of thereport.

The Waiting List Information section contains more detailed information on how many candidates areon the waiting list at the program, the types of candidates on the waiting list, how long candidatestypically have to wait for a transplant at this program, how frequently candidates successfully receive atransplant, and how often candidates on the waiting list die before receiving a transplant.

Table B1 shows the activity on this program's waiting list during two recent 1-year periods and providescomparisons to all programs within this program's OPTN region (seehttp://optn.transplant.hrsa.gov/members/regions.asp for information on OPTN regions) and the nationas a whole. Tables B2 and B3 describe the candidates on the waiting list at this program, withcomparisons to candidates waiting in the same donor service area (OPO/DSA) the OPTN region, andthe nation as a whole.

Table B4 shows how many candidates were removed from the waiting list because they received atransplant. The program's transplant rate is calculated as the number of candidates who received atransplant divided by the person-years observed at the program (person-years is a combination of howmany candidates were on the waiting list along with how long each candidate was followed since somecandidates are not on the waiting list for the entire year). The transplant rate and comparisons to whatwould be expected at this program are presented in Figures B1 and B2. Figure B1 shows thetransplant rate compared to what was expected at this program. The expected transplant rate is anestimate of what we would expect at this program if it were performing transplants at rates similar toother programs in the US with similar candidates on their waiting lists. The expected rate is only anestimate, and is made with a certain level of uncertainty. This uncertainty is shown in Figure B2. FigureB2 displays the ratio of the observed to the expected transplant rate. A ratio of 1 indicates that theobserved transplant rate was equal to the expected transplant rate, while a ratio less than 1 indicatesthe observed rate was lower than expected rate and a ratio greater than 1 indicates the observed ratewas higher than the expected rate. However, the level of uncertainty must be considered wheninterpreting these numbers. The 95% interval is also shown on Figure B2. This interval provides arange within which the true ratio of observed to expected transplant rates is likely to be. If this



The data reported here were prepared by the Scientific Registry of Transplant Recipients (SRTR)under contract with the Health Resources and Services Administration (HRSA). Page: ii

User Guide

confidence interval includes (crosses) 1.0, then we cannot say that this program's observed transplantrate is different from what would be expected. The observed transplant rate at this program was 13.6per 100 person-years. Transplant rates are also provided for adult and pediatric patients separatelyalong with comparisons to adult and pediatric rates in the DSA, the OPTN region, and the nation.Transplant rates are also presented excluding transplants from a living donor (Table B4D and FiguresB1D-B3D). Please refer to the PSR Technical Methods documentation available at http://www.srtr.orgfor more detail regarding how expected rates are calculated.

The death rate (also known as the mortality rate) for candidates on the waiting list is presented in TableB5 and Figures B4-B6. These data are presented in the same way as the transplant rate data in theprevious section. The intent of these tables and figures is to describe risk of death once candidates arelisted rather than while they are listed. Therefore, time at risk and deaths after removal from the waitinglist for reasons other than transplant, transfer to another transplant program, or recovery (no longerneeding a transplant), and before any subsequent transplant, are included. As with transplant rates,mortality rates should be interpreted carefully taking into consideration the interval displayed in FigureB5. For a complete description of how observed and expected mortality rates are calculated, pleaserefer to the technical documentation available at http://www.srtr.org.

Table B6 presents information on what happens to candidates on the waiting list by three different timepoints after listing: 6 months, 12 months, and 18 months. The table displays percentages of candidateswho have died, been removed from the waiting list, been transplanted, or been transferred orlost-to-follow-up. Tables B7 and B8 provide more detail regarding how many candidates have receiveda deceased donor transplant by certain time points during the first 3 years after being put on thetransplant waiting list. Each row of Tables B7 and B8 presents the percent of candidates who receiveda deceased donor transplant by each time point. Table B9 presents data on the time it took for differentpercentages of patients to be transplanted for candidates added to the list between 01/01/2012 and06/30/2017. The time it took for 5% (the 5th percentile) of patients to receive a transplant at thisprogram was 1.6 months. If "Not Observed" is displayed in the table, then too few candidates receivedtransplants before 12/31/2017 to calculate a particular percentile of transplant times.

Table B10 contains a summary of the offer acceptance practices of the program. The offer acceptanceratio indicates whether the program is more or less likely to accept offers than the average program. Ifthe offer acceptance ratio is greater than 1.0, then the program tends to accept more offers thanaverage; if the offer acceptance ratio is less than 1.0, then the program tends to accept fewer offersthan average. Figures B7 shows the distribution of program offer acceptance rates as well as the offeracceptance rate for this program. Figures B8 - B11 similarly show offer acceptance rates for subsets ofoffers.

The Transplant Information section begins with descriptions of transplant recipients in Tables C1 andC2. Data on recipients of deceased donor transplants are presented (Tables C1D and C2D); ifapplicable, data on recipients of living donor transplants are presented separately (Tables C1L andC2L). Comparisons to the region and the nation as a whole are provided. A description of thedeceased donors used at this program is provided in Table C3D, along with characteristics of livingdonors in Table C3L, if applicable. Finally, information on the transplant procedure for deceased andliving donor transplants is presented in Tables C4D and C4L, respectively.



The data reported here were prepared by the Scientific Registry of Transplant Recipients (SRTR)under contract with the Health Resources and Services Administration (HRSA). Page: iii

User Guide

Starting with Table C5, transplant outcomes are presented along with comparisons to what would beexpected at this program and what happened in the nation as a whole. Tables C5-C10 presentinformation on graft survival (survival of the transplanted organ), with data presented separately foradult and pediatric recipients. Patients are followed from the time of transplant until either failure of thetransplanted organ or death, whichever comes first. Please refer to the technical methods for moreinformation on these calculations (http://www.srtr.org).

While Tables C5-C10 present data on graft survival, Tables C11-C16 present information on patientsurvival. For these tables, patients are followed from the time of transplant until death, regardless ofwhether the transplant is functioning or the patient required another transplant to survive.

Tables C17 and C18 summarize the multiorgan transplant outcomes at this program. The summarystatistics in these tables are descriptive and are not risk-adjusted for different donor and candidatecharacteristics.

Table D1 shows the rates of follow-up for living donors.

Additional information regarding the technical methods and the risk adjustment models used toestimate expected event rates is available on the SRTR website at http://www.srtr.org. We welcomeand encourage feedback on these reports. Please feel free to share feedback with the SRTR at thefollowing e-mail: [email protected].



The data reported here were prepared by the Scientific Registry of Transplant Recipients (SRTR)under contract with the Health Resources and Services Administration (HRSA). Page: iv

Table of Contents

Section Page

User Guide iA. Program SummaryProgram Summary 1B. Waiting List InformationWaiting list activity 2Demographic characteristics of waiting list candidates 3Medical characteristics of waiting list candidates 4Transplant rates 5Deceased donor transplant rates 6Waiting list mortality rates 7Waiting list candidate status after listing 8Percent of candidates with deceased donor transplants: demographic characteristics 9Percent of candidates with deceased donor transplants: medical characteristics 10Time to transplant for waiting list candidates 11Offer acceptance practices 12C. Transplant InformationDeceased donor transplant recipient demographic characteristics 14Living donor transplant recipient demographic characteristics 15Deceased donor transplant recipient medical characteristics 16Living donor transplant recipient medical characteristics 17Deceased donor characteristics 18Living donor characteristics 19Deceased donor transplant characteristics 20Living donor transplant characteristics 21Graft survival 22Patient survival 40Multi-organ transplant graft survival 58Multi-organ transplant patient survival 58D. Living Donor InformationLiving donor follow-up summary 59



The data reported here were prepared by the Scientific Registry of Transplant Recipients (SRTR)under contract with the Health Resources and Services Administration (HRSA). Page: 1

A. Program Summary

Figure A1. Waiting list and transplant activity

Living donortransplants

Deceased donortransplants

Totaltransplants

New additionsto the waiting list

Activeon waiting list*

Totalon waiting list*

1510

2029

3539

8988

135131

213288

* At the end of the 12-month period01/01/2016 - 12/31/2016 01/01/2017 - 12/31/2017

Table A1. Census of transplant recipients

01/01/2016- 01/01/2017-Recipients

12/31/2016 12/31/2017

Transplanted at this center 39 35Followed by this center* 295 309

...transplanted at this program 277 291

...transplanted elsewhere 18 18

* Recipients followed are transplant recipients for whom thecenter has submitted a post-transplant follow-up form for atransplant that took place before the 12-month interval foreach column.

Figure A2. Transplant rates01/01/2016 - 12/31/2017

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Totaltransplant rate

Deceased donortransplant rate

0

5

10

15

20

25

13.6

19.2

9.0

14.4

Observed Expected

Figure A3. Waiting list mortality rates01/01/2016 - 12/31/2017

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Waiting listmortality rate

0

2

4

6

8

10

5.8 8.4

Observed Expected

Figure A4. First-year adult graft and patientsurvival: 01/01/2015 - 06/30/2017

Graft Failures(56 transplants)

Patient Deaths(54 transplants)

0.0

0.5

1.0

1.5

2.0

2.00

1.50

1.00

0.67

Observed Expected

Figure A5. First-year pediatric graft and patientsurvival: 01/01/2015 - 06/30/2017

This center did not perform anytransplants relevant to

this figure during01/01/2015-06/30/2017




B. Waiting List Information

Table B1. Waiting list activity summary: 01/01/2016 - 12/31/2017

Activity for 01/01/2017 to 12/31/2017Counts for

as percent of registrants on waiting listthis center

on 01/01/2017Waiting List Registrations 01/01/2016- 01/01/2017- This Center OPTN Region U.S.

12/31/2016 12/31/2017 (%) (%) (%)

On waiting list at start 313 288 100.0 100.0 100.0Additions

New listings at this center 88 89 30.9 35.6 35.3Removals

Transferred to another center 5 10 3.5 1.3 1.3Received living donor transplant* 10 15 5.2 8.0 5.5Received deceased donor transplant* 29 20 6.9 12.9 13.5Died 6 2 0.7 4.0 4.2Transplanted at another center 9 10 3.5 3.4 3.0Deteriorated 31 61 21.2 4.3 4.6Recovered 2 2 0.7 0.3 0.2Other reasons 21 44 15.3 6.5 5.6

On waiting list at end of period 288 213 74.0 94.8 97.5

* These patients were removed from waiting list with removal code indicating transplant; this may not equal thenumber of transplants performed at this center during the specified period.





Table B2. Demographic characteristics of waiting list candidatesCandidates registered on the waiting list between 01/01/2017 and 12/31/2017

New Waiting List Registrations All Waiting List Registrations01/01/2017 to 12/31/2017 (%) on 12/31/2017 (%)

Demographic CharacteristicThis Center OPTN Region U.S. This Center OPTN Region U.S.

(N=89) (N=2,926) (N=36,694) (N=213) (N=7,797) (N=101,504)

All (%) 100.0 100.0 100.0 100.0 100.0 100.0Ethnicity/Race (%)*

White 49.4 56.1 44.1 40.8 47.9 36.2African-American 30.3 21.6 27.8 32.9 28.4 32.8Hispanic/Latino 12.4 13.0 18.4 16.4 12.6 20.0Asian 6.7 7.2 8.0 8.5 7.9 9.4Other 1.1 2.0 1.8 1.4 3.2 1.6Unknown 0.0 0.0 0.0 0.0 0.0 0.0

Age (%)<2 years 0.0 0.3 0.2 0.0 0.2 0.12-11 years 0.0 1.0 1.1 0.0 0.6 0.512-17 years 0.0 1.3 1.6 0.0 0.8 0.918-34 years 11.2 11.5 11.0 12.2 10.9 10.935-49 years 31.5 25.2 25.4 31.5 28.3 28.050-64 years 43.8 42.8 41.4 44.6 45.2 43.665+ years 13.5 18.0 19.2 11.7 14.0 15.9Other (includes prenatal) 0.0 0.0 0.0 0.0 0.0 0.0

Gender (%)Male 70.8 61.1 61.9 58.2 60.3 61.3Female 29.2 38.9 38.1 41.8 39.7 38.7

* Race and ethnicity are reported together as a single data element, reflecting their data collection (either race orethnicity is required, but not both). Patients formerly coded as white and Hispanic are coded as Hispanic. Raceand ethnicity sum to 100%.





Table B3. Medical characteristics of waiting list candidatesCandidates registered on the waiting list between 01/01/2017 and 12/31/2017

New Waiting List Registrations All Waiting List Registrations01/01/2017 to 12/31/2017 (%) on 12/31/2017 (%)

Medical CharacteristicThis Center OPTN Region U.S. This Center OPTN Region U.S.

(N=89) (N=2,926) (N=36,694) (N=213) (N=7,797) (N=101,504)

All (%) 100.0 100.0 100.0 100.0 100.0 100.0Blood Type (%)

O 56.2 45.5 48.4 52.6 52.4 53.1A 30.3 35.0 32.8 27.7 28.4 27.6B 12.4 15.6 14.9 17.8 16.8 16.8AB 1.1 4.0 3.9 1.9 2.4 2.6Unknown 0.0 0.0 0.0 0.0 0.0 0.0

Previous Transplant (%)Yes 7.9 17.3 13.1 7.5 18.6 14.0No 92.1 82.7 86.9 92.5 81.4 86.0Unknown 0.0 0.0 0.0 0.0 0.0 0.0

Initial CPRA (%)0-9% 86.5 80.2 79.7 85.9 78.7 81.110-79% 7.9 12.4 12.5 10.3 13.4 11.580+% 5.6 7.3 7.7 3.8 7.9 7.3Unknown 0.0 0.1 0.1 0.0 0.0 0.1

Primary Disease (%)*Glomerular Diseases 22.5 22.8 20.2 20.2 21.5 19.2Tubular and Interstitial Diseases 4.5 5.3 4.2 1.9 4.7 3.6Polycystic Kidneys 7.9 7.8 7.6 6.1 7.8 7.0Congenital, Familial, Metabolic 1.1 2.7 2.3 0.5 2.2 1.7Diabetes 23.6 26.9 33.1 32.9 29.7 34.9Renovascular & Vascular Diseases 0.0 0.2 0.2 0.0 0.2 0.1Neoplasms 0.0 0.3 0.3 0.0 0.4 0.3Hypertensive Nephrosclerosis 21.3 19.2 19.7 20.2 21.1 22.8Other 19.1 14.3 12.0 17.8 11.8 10.0Missing* 0.0 0.4 0.4 0.5 0.6 0.4

* When "retransplant" is indicated, the primary disease is passed forward from the prior transplant in order toindicate the initial primary disease causing organ failure. "Missing" may include some patients for whomretransplant is indicated but no prior diagnosis can be found.





Table B4. Transplant rates: 01/01/2016 - 12/31/2017

Waiting List Registrations This Center OPO/DSA Region U.S.

All CandidatesCount on waiting list at start* 313 980 8,887 105,878Person Years** 543.8 1,850.3 16,503.6 207,699.0Removals for Transplant 74 268 3,423 38,707

Adult (18+) CandidatesCount on waiting list at start* 313 975 8,758 104,397Person Years** 543.8 1,839.5 16,250.6 204,728.2Removals for transpant 74 255 3,302 37,004

Pediatric (<18) CandidatesCount on waiting list at start* -- -- -- --Person Years** -- -- -- --Removals for transplant -- -- -- --

* Counts in this table may be lower than similar counts in other waiting list tables, such as Table B1. A smallpercentage (~1%) of patients are found to have died or been transplanted before being removed from the waitinglist, so these patients are excluded if the event occurs prior to the start of the study period. Inactive time on thewaiting list is included in the calculations for this table.** Person years are calculated as days (converted to fractional years). The number of days from January 1 or fromthe date of first wait listing until death, transplant, removal from the waiting list or December 31.

Figure B1. Observed and expected transplant rates:01/01/2016 - 12/31/2017

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All Adult Pediatric0

5

10

15

20

13.6

19.2

13.6

19.2

NA

NA

Observed Expected

Figure B2. Transplant rate ratioestimate

0.2

0.5

1.0

2.0

5.0

0.56

0.88

0.71

Est

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spla

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Figure B3. Observed adult (18+) and pediatric (<18)transplant rates: 01/01/2016 - 12/31/2017

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Adult (18+)0

5

10

15

20

13.6

13.9

20.3

18.1

Pediatric (<18)0.0

0.2

0.4

0.6

0.8

1.0

NA

NA

NA

NA

This Center OPO/DSA Region U.S.





Table B4D. Deceased donor transplant rates: 01/01/2016 - 12/31/2017


All CandidatesCount on waiting list at start* 313 980 8,887 105,878Person Years** 543.8 1,850.3 16,503.6 207,699.0Removals for Transplant 49 176 2,059 27,410

Adult (18+) CandidatesCount on waiting list at start* 313 975 8,758 104,397Person Years** 543.8 1,839.5 16,250.6 204,728.2Removals for transpant 49 167 1,995 26,228

Pediatric (<18) CandidatesCount on waiting list at start* -- -- -- --Person Years** -- -- -- --Removals for transplant -- -- -- --

* Counts in this table may be lower than similar counts in other waiting list tables, such as Table B1. A smallpercentage (~1%) of patients are found to have died or been transplanted before being removed from the waitinglist, so these patients are excluded if the event occurs prior to the start of the study period. Inactive time on thewaiting list is included in the calculations for this table.** Person years are calculated as days (converted to fractional years). The number of days from January 1 or fromthe date of first wait listing until death, transplant, removal from the waiting list or December 31.

Figure B1D. Observed and expected deceased donortransplant rates: 01/01/2016 - 12/31/2017

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5

10

15

9.0

14.4

9.0

14.4

NA

NA

Observed Expected

Figure B2D. Deceased donortransplant rate ratio estimate

0.2

0.5

1.0

2.0

5.0

0.47

0.82

0.63

Est

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Figure B3D. Observed adult (18+) and pediatric (<18)deceased donor transplant rates: 01/01/2016 - 12/31/2017

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Adult (18+)02468

101214

9.0

9.1

12.3

12.8

Pediatric (<18)0.0

0.2

0.4

0.6

0.8

1.0

NA

NA

NA

NA






Table B5. Waiting list mortality rates: 01/01/2016 - 12/31/2017


All CandidatesCount on waiting list at start* 313 980 8,887 105,878Person Years** 656.6 2,025.9 18,314.2 226,246.5Number of deaths 38 117 989 12,390

Adult (18+) CandidatesCount on waiting list at start* 313 975 8,758 104,397Person Years** 656.6 2,015.1 18,047.7 223,150.7Number of deaths 38 117 987 12,339

Pediatric (<18) CandidatesCount on waiting list at start* -- -- -- --Person Years** -- -- -- --Number of deaths -- -- -- --

* Counts in this table may be lower than similar counts in other waiting list tables, such as Table B1. A smallpercentage (~1%) of patients are found to have died or been transplanted before being removed from the waitinglist, so these patients are excluded if the event occurs prior to the start of the study period. Inactive time on thewaiting list is included in the calculations for this table.** Person years are calculated as days (converted to fractional years). The number of days from January 1 or fromthe date of first wait listing until death, transplant, 60 days after recovery, transfer or December 31.

Figure B4. Observed and expected waiting list mortality rates:01/01/2016 - 12/31/2017

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2

4

6

8

5.8

8.4

5.8

8.4

NA

NA

Observed Expected

Figure B5. Waiting list mortalityrate ratio estimate

0.2

0.5

1.0

2.0

5.0

0.50

0.93

0.70

Est

imat

ed M

ort

alit

y R

ate

Rat

io

Figure B6. Observed adult (18+) and pediatric (<18)waiting list mortality rates: 01/01/2016 - 12/31/2017

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Adult (18+)0123456

5.8

5.8

5.5

5.5

Pediatric (<18)0.0

0.2

0.4

0.6

0.8

1.0

NA

NA

NA

NA






Table B6. Waiting list candidate status after listingCandidates registered on waiting list between 07/01/2015 and 06/30/2016

This Center (N=86) U.S. (N=36,179)Waiting list status (survival status) Months Since Listing Months Since Listing

6 12 18 6 12 18

Alive on waiting list (%) 67.4 57.0 40.7 79.4 67.3 57.9Died on the waiting list without transplant (%) 1.2 1.2 1.2 1.3 2.3 3.3Removed without transplant (%):

Condition worsened (status unknown) 5.8 8.1 15.1 0.8 1.7 2.7Condition improved (status unknown) 1.2 1.2 1.2 0.1 0.2 0.2Refused transplant (status unknown) 0.0 0.0 0.0 0.1 0.2 0.3Other 2.3 3.5 7.0 0.7 1.7 2.8

Transplant (living donor from waiting list only) (%):Functioning (alive) 2.3 7.0 8.1 6.5 9.8 9.8Failed-Retransplanted (alive) 0.0 0.0 0.0 0.0 0.0 0.0Failed-alive not retransplanted 0.0 0.0 0.0 0.0 0.0 0.0Died 0.0 0.0 0.0 0.0 0.1 0.1Status Yet Unknown** 0.0 0.0 1.2 0.1 0.3 2.1

Transplant (deceased donor) (%):Functioning (alive) 11.6 10.5 11.6 9.3 12.9 13.6Failed-Retransplanted (alive) 0.0 0.0 0.0 0.0 0.0 0.0Failed-alive not retransplanted 2.3 1.2 0.0 0.0 0.0 0.0Died 3.5 5.8 7.0 0.2 0.4 0.5Status Yet Unknown* 2.3 3.5 4.7 1.2 2.5 5.5

Lost or Transferred (status unknown) (%) 0.0 1.2 2.3 0.3 0.7 1.0

TOTAL (%) 100.0 100.0 100.0 100.0 100.0 100.0

Total % known died on waiting list or after transplant 4.7 7.0 8.1 1.5 2.7 4.0Total % known died or removed as unstable 10.5 15.1 23.3 2.3 4.5 6.7Total % removed for transplant 22.1 27.9 32.6 17.3 26.0 31.7Total % with known functioning transplant (alive) 14.0 17.4 19.8 15.8 22.7 23.3

* Follow-up form covering specified time period not yet completed, and possibly has not become due.





Table B7. Percent of candidates with deceased donor transplants: demographic characteristicsCandidates registered on the waiting list between 01/01/2012 and 12/31/2014

Percent transplanted at time periods since listingCharacteristic This Center United States

N 30 day 1 year 2 years 3 years N 30 day 1 year 2 years 3 years

All 289 2.4 8.7 10.4 13.1 94,719 2.0 10.6 17.3 22.8Ethnicity/Race*

White 156 3.8 11.5 14.1 16.0 38,286 2.6 12.5 19.6 25.0African-American 66 0.0 3.0 4.5 9.1 30,117 1.5 9.1 15.4 21.2Hispanic/Latino 47 0.0 8.5 8.5 10.6 16,997 2.1 10.0 16.5 22.1Asian 13 0.0 0.0 0.0 7.7 7,724 1.3 8.5 14.9 20.2Other 7 14.3 14.3 14.3 14.3 1,595 1.4 9.9 17.0 23.4Unknown 0 -- -- -- -- 0 -- -- -- --

Age<2 years 0 -- -- -- -- 150 4.7 34.7 53.3 62.72-11 years 0 -- -- -- -- 802 6.9 50.0 64.7 71.412-17 years 0 -- -- -- -- 1,353 8.5 48.2 59.9 66.218-34 years 21 0.0 4.8 4.8 4.8 9,639 1.4 9.2 17.5 25.535-49 years 82 0.0 4.9 8.5 14.6 24,104 1.6 8.8 15.4 21.550-64 years 131 4.6 9.9 10.7 13.0 41,524 2.1 9.9 16.0 21.165+ years 55 1.8 12.7 14.5 14.5 17,147 1.8 10.5 17.0 21.4Other (includes prenatal) 0 -- -- -- -- 0 -- -- -- --

GenderMale 179 2.8 9.5 11.2 14.0 57,892 2.1 10.4 16.8 22.2Female 110 1.8 7.3 9.1 11.8 36,827 1.9 10.9 18.0 23.8






Table B8. Percent of candidates with deceased donor transplants: medical characteristicsCandidates registered on the waiting list between 01/01/2012 and 12/31/2014

Percent transplanted at time periods since listingCharacteristic This Center United States

N 30 day 1 year 2 years 3 years N 30 day 1 year 2 years 3 years

All 289 2.4 8.7 10.4 13.1 94,719 2.0 10.6 17.3 22.8Blood Type

O 119 3.4 8.4 10.1 10.1 46,707 1.8 9.1 14.5 19.4A 114 2.6 8.8 8.8 12.3 30,053 2.3 12.7 21.5 28.4B 40 0.0 10.0 15.0 20.0 14,422 1.6 7.8 13.1 17.4AB 16 0.0 6.2 12.5 25.0 3,537 3.6 23.0 35.2 43.0

Previous TransplantYes 27 0.0 14.8 14.8 14.8 13,789 1.8 11.0 18.4 24.6No 262 2.7 8.0 9.9 13.0 80,930 2.0 10.5 17.1 22.5

Peak PRA/CPRA0-9% 252 2.4 8.3 9.9 12.3 78,048 2.1 10.2 16.7 22.110-79% 28 3.6 7.1 10.7 17.9 9,848 1.5 11.4 19.1 25.680+% 9 0.0 22.2 22.2 22.2 6,815 1.9 13.3 21.6 27.8Unknown 0 -- -- -- -- 6 100.0 100.0 100.0 100.0

Primary Disease*Glomerular Diseases 43 4.7 7.0 9.3 11.6 16,956 1.7 11.7 19.6 26.8Tubular & Interstitial Diseases 15 0.0 20.0 20.0 20.0 3,462 3.5 15.0 22.7 28.0Polycystic Kidneys 14 0.0 0.0 0.0 0.0 6,006 1.4 10.1 18.2 25.0Congenital, Familial, Metabolic 5 0.0 0.0 0.0 0.0 1,720 3.8 24.4 35.6 44.0Diabetes 102 0.0 2.9 3.9 4.9 33,373 1.2 7.4 12.6 16.9Renovascular & VascularDiseases 0 -- -- -- -- 148 0.0 9.5 18.2 23.6

Neoplasms 0 -- -- -- -- 311 1.3 12.9 24.1 32.2Hypertensive Nephrosclerosis 61 0.0 4.9 9.8 16.4 21,726 1.3 9.0 15.7 21.7Other 46 10.9 28.3 28.3 32.6 10,587 6.3 18.8 26.2 31.3Missing* 3 0.0 0.0 0.0 0.0 430 0.9 7.0 12.3 18.6






Table B9. Time to transplant for waiting list candidates*Candidates registered on the waiting list between 01/01/2012 and 06/30/2017

Months to Transplant**Percentile Center OPO/DSA Region U.S.

5th 1.6 1.6 1.2 1.410th 5.4 4.4 3.4 3.625th 23.7 18.1 11.9 13.450th (median time to transplant) Not Observed Not Observed 53.7 60.575th Not Observed Not Observed Not Observed Not Observed

* If cells contain "Not Observed" fewer than that percentile of patients had received a transplant. For example, the50th percentile of time to transplant is the time when 50% of candidates have received transplants. If waitingtimes are long, then the 50th percentile may not be observed during the follow-up period for this table. Also, ifmore than 50% of candidates are removed from the list due to death or other reasons before receivingtransplants, then the 50th percentile of time to transplant will not be observed.

** Censored on 12/31/2017. Calculated as the months after listing, during which the corresponding percent ofall patients initially listed had received a transplant.





Table B10. Offer Acceptance Practices: 01/01/2017 - 12/31/2017

Offers Acceptance Characteristics This Center OPO/DSA Region U.S.

OverallNumber of Offers 1,935 8,241 95,582 1,544,761Number of Acceptances 15 68 971 13,037Expected Acceptances 29.1 101.8 1,014.9 13,025.1Offer Acceptance Ratio* 0.55 0.67 0.96 1.00 95% Credible Interval** [0.32, 0.84] -- -- --

Low-KDRI Donors (KDRI < 1.05)Number of Offers 643 2,081 20,898 180,162Number of Acceptances 11 34 343 5,070Expected Acceptances 11.4 40.7 406.0 5,066.0Offer Acceptance Ratio* 0.97 0.84 0.85 1.00 95% Credible Interval** [0.52, 1.57] -- -- --

Medium-KDRI Donors (1.05 < KDRI < 1.75)Number of Offers 1,196 4,883 58,982 1,037,759Number of Acceptances 4 33 542 6,824Expected Acceptances 16.6 54.7 518.2 6,817.9Offer Acceptance Ratio* 0.32 0.62 1.05 1.00 95% Credible Interval** [0.12, 0.63] -- -- --

High-KDRI Donors (KDRI > 1.75)Number of Offers 96 1,277 15,702 326,840Number of Acceptances 0 1 86 1,143Expected Acceptances 1.1 6.5 90.7 1,141.1Offer Acceptance Ratio* 0.64 0.35 0.95 1.00 95% Credible Interval** [0.08, 1.79] -- -- --

Hard-to-Place Kidneys (Over 100 Offers)Number of Offers 1,294 5,694 77,325 1,324,858Number of Acceptances 0 0 75 1,673Expected Acceptances 1.7 7.5 107.9 1,681.4Offer Acceptance Ratio* 0.55 0.21 0.70 1.00 95% Credible Interval** [0.07, 1.53] -- -- --

* The offer acceptance ratio estimates the relative offer acceptance practice of Aurora St. Luke's Medical Center (WISL)compared to the national offer acceptance practice. A ratio above one indicates the program is more likely to accept an offercompared to national offer acceptance practices (e.g., an offer acceptance ratio of 1.25 indicates a 25% more likely toaccept an offer), while a ratio below one indicates the program is less likely to accept an offer compared to national offeracceptance practices (e.g., an offer acceptance ratio of 0.75 indicates a 25% less likely to accept an offer).** As an example, the 95% Credible Interval for the overall offer acceptance ratio, [0.32, 0.84], indicates the location ofWISL's true offer acceptance ratio with 95% probability. The best estimate is 45% less likely to accept an offer compared tonationalacceptance behavior, but WISL's performance could plausibly range from 68% reduced acceptance up to 16%reduced acceptance.





Figure B7. Offer acceptance: Overall

WISL

0.1 0.4 2.5 10NationalAverage

Lower Higher

Figure B8. Offer acceptance: Low-KDRI

WISL


Lower Higher

Figure B9. Offer acceptance: Medium-KDRI

WISL


Lower Higher

Figure B10. Offer acceptance: High-KDRI

WISL


Lower Higher

Figure B11. Offer acceptance: Offer number > 100

WISL


Lower Higher




C. Transplant Information

Table C1D. Deceased donor transplant recipient demographic characteristicsPatients transplanted between 01/01/2017 and 12/31/2017

Percentage in each categoryCharacteristic Center Region U.S.

(N=20) (N=1,062) (N=14,037)

Ethnicity/Race (%)*White 30.0 44.7 38.5African-American 50.0 29.3 32.6Hispanic/Latino 10.0 14.9 19.3Asian 10.0 8.4 7.7Other 0.0 2.7 1.9Unknown 0.0 0.0 0.0

Age (%)<2 years 0.0 0.0 0.12-11 years 0.0 1.4 1.512-17 0.0 1.5 2.118-34 10.0 12.7 10.535-49 years 40.0 24.9 24.950-64 years 35.0 41.6 41.465+ years 15.0 17.9 19.6Unknown 0.0 0.0 0.0

Gender (%)Male 70.0 57.3 60.3Female 30.0 42.7 39.7






Table C1L. Living donor transplant recipient demographic characteristicsPatients transplanted between 01/01/2017 and 12/31/2017


(N=15) (N=667) (N=5,812)

Ethnicity/Race (%)*White 53.3 72.4 66.1African-American 13.3 9.7 12.3Hispanic/Latino 33.3 11.8 14.5Asian 0.0 5.2 6.1Other 0.0 0.7 0.9Unknown 0.0 0.0 0.0








Table C2D. Deceased donor transplant recipient medical characteristicsPatients transplanted between 01/01/2017 and 12/31/2017


(N=20) (N=1,062) (N=14,037)

Blood Type (%)O 50.0 41.8 46.4A 50.0 38.6 34.9B 0.0 14.2 13.5AB 0.0 5.4 5.2

Previous Transplant (%)Yes 15.0 17.8 14.5No 85.0 82.2 85.5

Peak PRA/CPRA Prior to Transplant (%)0-9% 40.0 53.2 58.210-79% 45.0 22.6 22.180+ % 15.0 24.2 19.6Unknown 0.0 0.0 0.0

Body Mass Index (%)0-20 5.0 10.2 10.321-25 35.0 26.4 28.926-30 25.0 30.5 31.231+ 35.0 32.4 28.7Unknown 0.0 0.6 1.0

Primary Disease (%)*Glomerular Diseases 25.0 23.6 22.6Tubular and Interstitial Disease 0.0 5.6 4.4Polycystic Kidneys 0.0 7.0 7.6Congenital, Familial, Metabolic 0.0 3.5 3.0Diabetes 25.0 24.6 26.9Renovascular & Vascular Diseases 0.0 0.3 0.2Neoplasms 0.0 0.7 0.4Hypertensive Nephrosclerosis 15.0 21.6 24.1Other Kidney 35.0 12.7 10.5Missing* 0.0 0.6 0.3






Table C2L. Living donor transplant recipient medical characteristicsPatients transplanted between 01/01/2017 and 12/31/2017


(N=15) (N=667) (N=5,812)

Blood Type (%)O 60.0 41.1 42.8A 26.7 41.7 39.8B 6.7 13.0 13.3AB 6.7 4.2 4.1

Previous Transplant (%)Yes 6.7 15.4 11.4No 93.3 84.6 88.6

Peak PRA/CPRA Prior to Transplant (%)0-9% 73.3 68.8 74.110-79% 20.0 21.9 20.580+ % 6.7 8.7 5.4Unknown 0.0 0.6 0.1

Body Mass Index (%)0-20 13.3 11.4 12.221-25 20.0 29.7 29.726-30 26.7 31.0 30.831+ 40.0 27.3 26.8Unknown 0.0 0.6 0.6

Primary Disease (%)*Glomerular Diseases 40.0 35.7 31.0Tubular and Interstitial Disease 6.7 5.4 5.0Polycystic Kidneys 13.3 12.1 13.4Congenital, Familial, Metabolic 0.0 4.8 4.1Diabetes 13.3 18.6 21.5Renovascular & Vascular Diseases 0.0 0.3 0.4Neoplasms 0.0 0.3 0.4Hypertensive Nephrosclerosis 13.3 14.1 15.9Other Kidney 6.7 8.2 7.8Missing* 6.7 0.4 0.3






Table C3D. Deceased donor characteristicsTransplants performed between 01/01/2017 and 12/31/2017

Percentage in each categoryDonor Characteristic Center Region U.S.

(N=20) (N=1,062) (N=14,037)

Cause of Death (%)Deceased: Stroke 25.0 25.5 23.9Deceased: MVA 20.0 14.4 15.5Deceased: Other 55.0 60.1 60.6

Ethnicity/Race (%)*White 75.0 71.8 67.5African-American 5.0 13.5 14.0Hispanic/Latino 20.0 11.3 14.7Asian 0.0 2.4 2.8Other 0.0 1.0 1.1Not Reported 0.0 0.0 0.0



Blood Type (%)O 50.0 45.5 48.4A 50.0 39.5 36.9B 0.0 11.4 11.2AB 0.0 3.6 3.5Unknown 0.0 0.0 0.0No 100.0 85.7 88.1






Table C3L. Living donor characteristicsTransplants performed between 01/01/2017 and 12/31/2017

Percentage in each categoryDonor Characteristic Center Region U.S.

(N=15) (N=667) (N=5,812)

Ethnicity/Race (%)*White 93.3 75.9 71.3African-American 6.7 7.6 8.8Hispanic/Latino 0.0 11.5 13.8Asian 0.0 3.6 4.7Other 0.0 1.3 1.4Not Reported 0.0 0.0 0.0

Age (%)0-11 years 0.0 0.0 0.012-17 0.0 0.0 0.018-34 6.7 25.9 27.035-49 years 26.7 39.7 39.150-64 years 60.0 29.1 29.765+ years 6.7 5.2 4.2Unknown 0.0 0.0 0.0


Blood Type (%)O 66.7 58.8 62.9A 20.0 32.5 27.9B 13.3 7.0 7.8AB 0.0 1.6 1.3Unknown 0.0 0.0 0.0






Table C4D. Deceased donor transplant characteristicsTransplants performed between 01/01/2017 and 12/31/2017

Percentage in each categoryTransplant Characteristic Center Region U.S.

(N=20) (N=1,062) (N=14,037)

Cold Ischemic Time (Hours): Local (%)Deceased: 0-11 hr 87.5 39.2 38.2Deceased: 12-21 hr 12.5 50.9 45.4Deceased: 22-31 hr 0.0 8.9 13.4Deceased: 32-41 hr 0.0 0.6 2.0Deceased: 42+ hr 0.0 0.0 0.5Not Reported 0.0 0.4 0.5

Cold Ischemic Time (Hours): Shared (%)Deceased: 0-11 hr 100.0 13.6 9.9Deceased: 12-21 hr 0.0 52.7 39.9Deceased: 22-31 hr 0.0 32.2 35.6Deceased: 32-41 hr 0.0 0.8 10.3Deceased: 42+ hr 0.0 0.0 3.8Not Reported 0.0 0.8 0.5

Level of Mismatch (%)A Locus Mismatches (%)

0 0.0 15.9 11.91 45.0 36.3 38.72 55.0 46.5 48.8Not Reported 0.0 1.2 0.5

B Locus Mismatches (%)0 0.0 10.5 7.61 20.0 24.9 25.22 80.0 63.4 66.6Not Reported 0.0 1.2 0.5

DR Locus Mismatches (%)0 5.0 21.2 17.31 30.0 44.2 47.32 65.0 33.4 34.9Not Reported 0.0 1.2 0.5

Total Mismatches (%)0 0.0 8.4 4.81 0.0 2.3 1.52 5.0 5.1 5.23 0.0 12.8 14.04 20.0 24.8 27.65 45.0 31.5 31.46 30.0 13.9 15.0Not Reported 0.0 1.2 0.5

Procedure Type (%)Kidney alone 75.0 92.1 93.3Kidney and another organ 25.0 7.9 6.7

Dialysis in First Week After Transplant (%)Yes 15.0 29.8 27.1No 85.0 70.2 72.9Not Reported 0.0 0.0 0.0

Sharing (%)Local 80.0 75.1 70.6Shared 20.0 24.9 29.4

Median Time in Hospital After Transplant* 7.0 Days 5.0 Days 5.0 Days

* Multiple organ transplants are excluded from this statistic.





Table C4L. Living donor transplant characteristicsTransplants performed between 01/01/2017 and 12/31/2017

Percentage in each categoryTransplant Characteristic Center Region U.S.

(N=15) (N=667) (N=5,812)

Relation with Donor (%)Related 33.3 44.7 43.7Unrelated 66.7 55.2 56.3Not Reported 0.0 0.1 0.1

Level of Mismatch (%)A Locus Mismatches (%)

0 6.7 19.8 18.01 60.0 51.1 50.12 33.3 28.8 30.7Not Reported 0.0 0.3 1.3

B Locus Mismatches (%)0 6.7 12.6 10.81 33.3 48.0 44.92 60.0 39.1 43.1Not Reported 0.0 0.3 1.3

DR Locus Mismatches (%)0 6.7 18.3 16.71 60.0 49.5 50.62 33.3 31.9 31.5Not Reported 0.0 0.3 1.3

Total Mismatches (%)0 0.0 6.6 5.41 6.7 4.2 4.12 6.7 15.7 13.63 20.0 24.4 23.74 26.7 16.9 17.65 20.0 19.5 22.86 20.0 12.3 11.5Not Reported 0.0 0.3 1.3

Procedure Type (%)Kidney alone 100.0 100.0 100.0Kidney and another organ 0.0 0.0 0.0

Dialysis in First Week After Transplant (%)Yes 6.7 3.3 2.8No 93.3 96.6 97.2Not Reported 0.0 0.1 0.0

Median Time in Hospital After Transplant* 6.0 Days 4.0 Days 4.0 Days

* Multiple organ transplants are excluded from this statistic.





Table C5. Adult (18+) 1-month survival with a functioning graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures

WISL U.S.

Number of transplants evaluated 56 42,472

Estimated probability of surviving with a functioning graft at 1 month(unadjusted for patient and donor characteristics) 96.43% 98.48%

Expected probability of surviving with a functioning graft at 1 month(adjusted for patient and donor characteristics) 98.99% --

Number of observed graft failures (including deaths)during the first month after transplant 2 647

Number of expected graft failures (including deaths)during the first month after transplant 0.55 --

Estimated hazard ratio* 1.57 --

95% credible interval for the hazard ratio** [0.43, 3.44] --

* The hazard ratio provides an estimate of how Aurora St. Luke's Medical Center (WISL)'s results compare with what was expectedbased on modeling the transplant outcomes from all U.S. programs. A ratio above 1 indicates higher than expected graft failurerates (e.g., a hazard ratio of 1.5 would indicate 50% higher risk), and a ratio below 1 indicates lower than expected graft failure rates(e.g., a hazard ratio of 0.75 would indicate 25% lower risk). If WISL's graft failure rate were precisely the expected rate, theestimated hazard ratio would be 1.0.** The 95% credible interval, [0.43, 3.44], indicates the location of WISL's true hazard ratio with 95% probability. The best estimateis 57% higher risk of graft failure compared to an average program, but WISL's performance could plausibly range from 57%reduced risk up to 244% increased risk.

Figure C1. Adult (18+) 1-monthgraft failure HR estimate

0.2

0.5

1.0

2.0

5.0

0.43

3.44

1.57

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C2. Adult (18+) 1-month graft failure HR programcomparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse

Program VolumeTransplants Performed 01/01/2015 - 06/30/2017

Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C5D. Adult (18+) 1-month survival with a functioning deceased donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures

WISL U.S.









Figure C1D. Adult (18+) 1-monthdeceased donor graft failure HRestimate

0.2

0.5

1.0

2.0

5.0

0.46

3.71

1.69

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C2D. Adult (18+) 1-month deceased donor graft failureHR program comparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C5L. Adult (18+) 1-month survival with a functioning living donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures

WISL U.S.








* The hazard ratio provides an estimate of how Aurora St. Luke's Medical Center (WISL)'s results compare with what was expectedbased on modeling the transplant outcomes from all U.S. programs. A ratio above 1 indicates higher than expected graft failurerates (e.g., a hazard ratio of 1.5 would indicate 50% higher risk), and a ratio below 1 indicates lower than expected graft failure rates(e.g., a hazard ratio of 0.75 would indicate 25% lower risk). If WISL's graft failure rate were precisely the expected rate, theestimated hazard ratio would be 1.0.** The 95% credible interval, [0.11, 2.54], indicates the location of WISL's true hazard ratio with 95% probability. The best estimateis 9% lower risk of graft failure compared to an average program, but WISL's performance could plausibly range from 89% reducedrisk up to 154% increased risk.

Figure C1L. Adult (18+) 1-monthliving donor graft failure HRestimate

0.2

0.5

1.0

2.0

5.0

0.11

2.54

0.91

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C2L. Adult (18+) 1-month living donor graft failure HRprogram comparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C6. Adult (18+) 1-year survival with a functioning graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures

WISL U.S.


Estimated probability of surviving with a functioning graft at 1 year(unadjusted for patient and donor characteristics) 96.43% 95.43%

Expected probability of surviving with a functioning graft at 1 year(adjusted for patient and donor characteristics) 97.02% --

Number of observed graft failures (including deaths)during the first year after transplant 2 1,818

Number of expected graft failures (including deaths)during the first year after transplant 1.50 --




Figure C3. Adult (18+) 1-yeargraft failure HR estimate

0.2

0.5

1.0

2.0

5.0

0.31

2.51

1.14

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C4. Adult (18+) 1-year graft failure HR programcomparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C6D. Adult (18+) 1-year survival with a functioning deceased donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures

WISL U.S.




Number of observed graft failures (including deaths)during the first year after transplant 2 1,569





Figure C3D. Adult (18+) 1-yeardeceased donor graft failure HRestimate

0.2

0.5

1.0

2.0

5.0

0.36

2.89

1.32

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C4D. Adult (18+) 1-year deceased donor graft failureHR program comparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C6L. Adult (18+) 1-year survival with a functioning living donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures

WISL U.S.




Number of observed graft failures (including deaths)during the first year after transplant 0 249





Figure C3L. Adult (18+) 1-yearliving donor graft failure HRestimate

0.1

0.2

0.5

1.0

2.0

5.0

10.0

0.10

2.26

0.81

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C4L. Adult (18+) 1-year living donor graft failure HRprogram comparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C7. Adult (18+) 3-year survival with a functioning graftSingle organ transplants performed between 07/01/2012 and 12/31/2014Deaths and retransplants are considered graft failures

WISL U.S.


Estimated probability of surviving with a functioning graft at 3 years(unadjusted for patient and donor characteristics) 85.14% 88.96%

Expected probability of surviving with a functioning graft at 3 years(adjusted for patient and donor characteristics) 89.47% --

Number of observed graft failures (including deaths)during the first 3 years after transplant 11 4,276

Number of expected graft failures (including deaths)during the first 3 years after transplant 7.56 --




Figure C5. Adult (18+) 3-yeargraft failure HR estimate

0.2

0.5

1.0

2.0

5.0

0.72

2.19

1.36

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C6. Adult (18+) 3-year graft failure HR programcomparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C7D. Adult (18+) 3-year survival with a functioning deceased donor graftSingle organ transplants performed between 07/01/2012 and 12/31/2014Deaths and retransplants are considered graft failures

WISL U.S.




Number of observed graft failures (including deaths)during the first 3 years after transplant 10 3,396





Figure C5D. Adult (18+) 3-yeardeceased donor graft failure HRestimate

0.2

0.5

1.0

2.0

5.0

0.79

2.51

1.53

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C6D. Adult (18+) 3-year deceased donor graft failureHR program comparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C7L. Adult (18+) 3-year survival with a functioning living donor graftSingle organ transplants performed between 07/01/2012 and 12/31/2014Deaths and retransplants are considered graft failures

WISL U.S.




Number of observed graft failures (including deaths)during the first 3 years after transplant 1 880





Figure C5L. Adult (18+) 3-yearliving donor graft failure HRestimate

0.2

0.5

1.0

2.0

5.0

0.17

1.94

0.81

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C6L. Adult (18+) 3-year living donor graft failure HRprogram comparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C8. Pediatric (<18) 1-month survival with a functioning graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures


this table during01/01/2015-06/30/2017

Figure C7. Pediatric (<18)1-month graft failure HR estimate



Figure C8. Pediatric (<18) 1-month graft failure HR programcomparison







Table C8D. Pediatric (<18) 1-month survival with a functioning deceased donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures



Figure C7D. Pediatric (<18)1-month deceased donor graftfailure HR estimate



Figure C8D. Pediatric (<18) 1-month deceased donor graftfailure HR program comparison







Table C8L. Pediatric (<18) 1-month survival with a functioning living donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures



Figure C7L. Pediatric (<18)1-month living donor graft failureHR estimate



Figure C8L. Pediatric (<18) 1-month living donor graft failureHR program comparison







Table C9. Pediatric (<18) 1-year survival with a functioning graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures



Figure C9. Pediatric (<18) 1-yeargraft failure HR estimate



Figure C10. Pediatric (<18) 1-year graft failure HR programcomparison







Table C9D. Pediatric (<18) 1-year survival with a functioning deceased donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures



Figure C9D. Pediatric (<18)1-year deceased donor graftfailure HR estimate



Figure C10D. Pediatric (<18) 1-year deceased donor graftfailure HR program comparison







Table C9L. Pediatric (<18) 1-year survival with a functioning living donor graftSingle organ transplants performed between 01/01/2015 and 06/30/2017Deaths and retransplants are considered graft failures



Figure C9L. Pediatric (<18) 1-yearliving donor graft failure HRestimate



Figure C10L. Pediatric (<18) 1-year living donor graft failureHR program comparison







Table C10. Pediatric (<18) 3-year survival with a functioning graftSingle organ transplants performed between 07/01/2012 and 12/31/2014Deaths and retransplants are considered graft failures



Figure C11. Pediatric (<18) 3-yeargraft failure HR estimate



Figure C12. Pediatric (<18) 3-year graft failure HR programcomparison







Table C10D. Pediatric (<18) 3-year survival with a functioning deceased donor graftSingle organ transplants performed between 07/01/2012 and 12/31/2014Deaths and retransplants are considered graft failures



Figure C11D. Pediatric (<18)3-year deceased donor graftfailure HR estimate



Figure C12D. Pediatric (<18) 3-year deceased donor graftfailure HR program comparison







Table C10L. Pediatric (<18) 3-year survival with a functioning living donor graftSingle organ transplants performed between 07/01/2012 and 12/31/2014Deaths and retransplants are considered graft failures



Figure C11L. Pediatric (<18)3-year living donor graft failureHR estimate



Figure C12L. Pediatric (<18) 3-year living donor graft failureHR program comparison







Table C11. Adult (18+) 1-month patient survivalSingle organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded

WISL U.S.


Estimated probability of surviving at 1 month(unadjusted for patient and donor characteristics) 98.15% 99.53%

Expected probability of surviving at 1 month(adjusted for patient and donor characteristics) 99.74% --

Number of observed deaths during the first month after transplant 1 173

Number of expected deaths during the first month after transplant 0.14 --



* The hazard ratio provides an estimate of how Aurora St. Luke's Medical Center (WISL)'s results compare with what was expectedbased on modeling the transplant outcomes from all U.S. programs. A ratio above 1 indicates higher than expected patient deathrates (e.g., a hazard ratio of 1.5 would indicate 50% higher risk), and a ratio below 1 indicates lower than expected patient deathrates (e.g., a hazard ratio of 0.75 would indicate 25% lower risk). If WISL's patient death rate were precisely the expected rate, theestimated hazard ratio would be 1.0.** The 95% credible interval, [0.29, 3.38], indicates the location of WISL's true hazard ratio with 95% probability. The best estimateis 40% higher risk of patient death compared to an average program, but WISL's performance could plausibly range from 71%reduced risk up to 238% increased risk.

Figure C13. Adult (18+) 1-monthpatient death HR estimate

0.2

0.5

1.0

2.0

5.0

0.29

3.38

1.40

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C14. Adult (18+) 1-month patient death HR programcomparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C11D. Adult (18+) 1-month patient survival (deceased donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded

WISL U.S.









Figure C13D. Adult (18+) 1-monthpatient death HR estimate(deceased donor grafts)

0.2

0.5

1.0

2.0

5.0

0.30

3.45

1.43

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C14D. Adult (18+) 1-month patient death HR programcomparison (deceased donor grafts)

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C11L. Adult (18+) 1-month patient survival (living donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded

WISL U.S.








* The hazard ratio provides an estimate of how Aurora St. Luke's Medical Center (WISL)'s results compare with what was expectedbased on modeling the transplant outcomes from all U.S. programs. A ratio above 1 indicates higher than expected patient deathrates (e.g., a hazard ratio of 1.5 would indicate 50% higher risk), and a ratio below 1 indicates lower than expected patient deathrates (e.g., a hazard ratio of 0.75 would indicate 25% lower risk). If WISL's patient death rate were precisely the expected rate, theestimated hazard ratio would be 1.0.** The 95% credible interval, [0.12, 2.73], indicates the location of WISL's true hazard ratio with 95% probability. The best estimateis 2% lower risk of patient death compared to an average program, but WISL's performance could plausibly range from 88%reduced risk up to 173% increased risk.

Figure C13L. Adult (18+) 1-monthpatient death HR estimate (livingdonor grafts)

0.2

0.5

1.0

2.0

5.0

0.12

2.73

0.98

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C14L. Adult (18+) 1-month patient death HR programcomparison (living donor grafts)

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C12. Adult (18+) 1-year patient survivalSingle organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded

WISL U.S.


Estimated probability of surviving at 1 year(unadjusted for patient and donor characteristics) 98.15% 97.50%

Expected probability of surviving at 1 year(adjusted for patient and donor characteristics) 98.63% --

Number of observed deaths during the first year after transplant 1 840

Number of expected deaths during the first year after transplant 0.67 --




Figure C15. Adult (18+) 1-yearpatient death HR estimate

0.2

0.5

1.0

2.0

5.0

0.23

2.71

1.12

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C16. Adult (18+) 1-year patient death HR programcomparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C12D. Adult (18+) 1-year patient survival (deceased donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded

WISL U.S.









Figure C15D. Adult (18+) 1-yearpatient death HR estimate(deceased donor grafts)

0.2

0.5

1.0

2.0

5.0

0.25

2.91

1.21

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C16D. Adult (18+) 1-year patient death HR programcomparison (deceased donor grafts)

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C12L. Adult (18+) 1-year patient survival (living donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded

WISL U.S.









Figure C15L. Adult (18+) 1-yearpatient death HR estimate (livingdonor grafts)

0.2

0.5

1.0

2.0

5.0

0.11

2.54

0.91

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C16L. Adult (18+) 1-year patient death HR programcomparison (living donor grafts)

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C13. Adult (18+) 3-year patient survivalSingle organ transplants performed between 07/01/2012 and 12/31/2014Retransplants excluded

WISL U.S.


Estimated probability of surviving at 3 years(unadjusted for patient and donor characteristics) 89.71% 93.71%

Expected probability of surviving at 3 years(adjusted for patient and donor characteristics) 93.95% --

Number of observed deaths during the first 3 years after transplant 7 2,136

Number of expected deaths during the first 3 years after transplant 3.92 --




Figure C17. Adult (18+) 3-yearpatient death HR estimate

0.2

0.5

1.0

2.0

5.0

0.70

2.66

1.52

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C18. Adult (18+) 3-year patient death HR programcomparison

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C13D. Adult (18+) 3-year patient survival (deceased donor graft recipients)Single organ transplants performed between 07/01/2012 and 12/31/2014Retransplants excluded

WISL U.S.




Number of observed deaths during the first 3 years after transplant 7 1,719





Figure C17D. Adult (18+) 3-yearpatient death HR estimate(deceased donor grafts)

0.2

0.5

1.0

2.0

5.0

0.78

2.99

1.71

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C18D. Adult (18+) 3-year patient death HR programcomparison (deceased donor grafts)

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C13L. Adult (18+) 3-year patient survival (living donor graft recipients)Single organ transplants performed between 07/01/2012 and 12/31/2014Retransplants excluded

WISL U.S.




Number of observed deaths during the first 3 years after transplant 0 417





Figure C17L. Adult (18+) 3-yearpatient death HR estimate (livingdonor grafts)

0.1

0.2

0.5

1.0

2.0

5.0

10.0

0.09

2.11

0.76

Est

imat

ed H

azar

d R

atio

(H

R)

Figure C18L. Adult (18+) 3-year patient death HR programcomparison (living donor grafts)

1 3 10 30 100 300 1000

0.2

0.5

1.0

2.0

5.0

Better

Worse


Est

imat

ed H

azar

d R

atio

(H

R)

WISL Other Programs





Table C14. Pediatric (<18) 1-month patient survivalSingle organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded



Figure C19. Pediatric (<18)1-month patient death HRestimate



Figure C20. Pediatric (<18) 1-month patient death HR programcomparison







Table C14D. Pediatric (<18) 1-month patient survival (deceased donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded



Figure C19D. Pediatric (<18)1-month patient death HRestimate (deceased donor grafts)



Figure C20D. Pediatric (<18) 1-month patient death HRprogram comparison (deceased donor grafts)







Table C14L. Pediatric (<18) 1-month patient survival (living donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded



Figure C19L. Pediatric (<18)1-month patient death HRestimate (living donor grafts)



Figure C20L. Pediatric (<18) 1-month patient death HRprogram comparison (living donor grafts)







Table C15. Pediatric (<18) 1-year patient survivalSingle organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded



Figure C21. Pediatric (<18) 1-yearpatient death HR estimate



Figure C22. Pediatric (<18) 1-year patient death HR programcomparison







Table C15D. Pediatric (<18) 1-year patient survival (deceased donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded



Figure C21D. Pediatric (<18)1-year patient death HR estimate(deceased donor grafts)



Figure C22D. Pediatric (<18) 1-year patient death HR programcomparison (deceased donor grafts)







Table C15L. Pediatric (<18) 1-year patient survival (living donor graft recipients)Single organ transplants performed between 01/01/2015 and 06/30/2017Retransplants excluded



Figure C21L. Pediatric (<18)1-year patient death HR estimate(living donor grafts)



Figure C22L. Pediatric (<18) 1-year patient death HR programcomparison (living donor grafts)







Table C16. Pediatric (<18) 3-year patient survivalSingle organ transplants performed between 07/01/2012 and 12/31/2014Retransplants excluded



Figure C23. Pediatric (<18) 3-yearpatient death HR estimate



Figure C24. Pediatric (<18) 3-year patient death HR programcomparison







Table C16D. Pediatric (<18) 3-year patient survival (deceased donor graft recipients)Single organ transplants performed between 07/01/2012 and 12/31/2014Retransplants excluded



Figure C23D. Pediatric (<18)3-year patient death HR estimate(deceased donor grafts)



Figure C24D. Pediatric (<18) 3-year patient death HR programcomparison (deceased donor grafts)







Table C16L. Pediatric (<18) 3-year patient survival (living donor graft recipients)Single organ transplants performed between 07/01/2012 and 12/31/2014Retransplants excluded



Figure C23L. Pediatric (<18)3-year patient death HR estimate(living donor grafts)



Figure C24L. Pediatric (<18) 3-year patient death HR programcomparison (living donor grafts)







Table C17. Multi-organ transplant graft survival: 01/01/2015 - 06/30/2017

Adult (18+) Transplants First-Year Outcomes

Transplant TypeTransplantsPerformed

KidneyGraft Failures

Estimated KidneyGraft Survival

WISL-TX1 USA WISL-TX1 USA WISL-TX1 USA

Kidney-Heart 6 371 0 43 100.0% 87.7%Kidney-Liver 24 1,718 10 189 57.7% 88.4%Kidney-Pancreas 4 1,879 0 67 100.0% 96.2%

Pediatric (<18) Transplants

No pediatric (<18) multi-organ transplants were performed

Table C18. Multi-organ transplant patient survival: 01/01/2015 - 06/30/2017

Adult (18+) Transplants First-Year Outcomes

Transplant TypeTransplantsPerformed Patient Deaths

Estimated Patient Survival

WISL-TX1 USA WISL-TX1 USA WISL-TX1 USA

Kidney-Heart 6 371 0 31 100.0% 91.1%Kidney-Liver 24 1,718 8 148 65.6% 90.8%Kidney-Pancreas 4 1,879 0 42 100.0% 97.6%

Pediatric (<18) Transplants

No pediatric (<18) multi-organ transplants were performed




D. Living Donor Information

Table D1. Living donor summary: 01/01/2015 - 12/31/2017

This Center United StatesLiving Donor Follow-Up 01/2015-

12/201501/2016-12/2016

01/2017-06/2017

01/2015-12/2015

01/2016-12/2016

01/2017-06/2017

Number of Living Donors 7 11 6 5,631 5,627 2,810

6-Month Follow-UpDonors due for follow-up 7 11 6 5,628 5,625 2,750

Timely clinical data 6 9 6 4,709 4,974 2,43585.7% 81.8% 100.0% 83.7% 88.4% 88.5%

Timely lab data 6 9 6 4,453 4,752 2,32385.7% 81.8% 100.0% 79.1% 84.5% 84.5%

12-Month Follow-UpDonors due for follow-up 7 11 5,625 5,602

Timely clinical data 6 9 4,458 4,71185.7% 81.8% 79.3% 84.1%

Timely lab data 6 9 4,083 4,44385.7% 81.8% 72.6% 79.3%

24-Month Follow-UpDonors due for follow-up 7 5,605

Timely clinical data 7 4,268100.0% 76.1%

Timely lab data 6 3,88785.7% 69.3%

Follow-up completion standards through 2 years post-donation were implemented in policy on February 1,2013.

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