National Center forResearch ResourcesNATIONAL INSTITUTES OF HEALTH T r a n s l a t I n g r e s e a r c h f r o m b a s i c d i s c o v e r y t o i m p r o v e d p a t I e n t c a r e
Update on Clinical Translational
Research
DCM Resource Directors Meeting
May 10, 2010
Louise E. Ramm, Ph.D.Deputy Director
National Center for Research Resources
National Institute of Health
NCRR
Clinical
Community
National Center for Research Resources (NCRR)Translating research from basic discovery to improved patient care
Improved
patient care
Pre-clinical
imaging &
informatics
advances
clinical research
support
research
capacity
& training
community
engagement
science
education
animal model
resources
NCRR
Challenges for NIH: The Translation Gap
Source: Butler D. Translational research: Crossing the valley of death. Nature. 2008;453:840–2.
NCRR
NCRR Supports the Continuum of Biomedical Research
2. NCRR provides NIH-supported laboratories and clinical researchers with the infrastructure, tools, and training they need to understand, detect, treat, and prevent diseases
3. NCRR helps build partnerships and networks among grantees to create a matrix of research support
1. NCRR provides animal models that bridge basic science and human medicine through specialized laboratory animals and research facilities
NCRR
Together, NCRR’s four integrated and complementary areas accelerate
and enhance research along the entire continuum of biomedical science.
NCRR’s 4 Programmatic Divisions
Working Synergistically
Comparative Medicine —
Essential to Translational Research
Translation
from
basic science to
human studies
Translation
of
new knowledge
into clinical practice
Basic
Research
Clinical
Research
Improved
Health
Adapted from Sung et al. (2003) JAMA, 289, 1278-89.
Copyright © (2003) American Medical Association. All Rights reserved.
NCRR
Nonhuman Primates
Rodents
Aquatics
Comparative models (e.g., Pigs, Invertebrates)
Genetic and Information Resources
Division of Comparative Medicine
Research and Resources
NCRR
~50 Centers in 5 Broad Areas
Scope: from basic discovery to clinical research
Scale: from molecule to organism
Technology for
Structural Biology
Synchrotron
x-ray
technologies
Electron
microscopy
Magnetic
resonance
Technology for
Systems Biology
Mass
spectrometry
Proteomics
Glycomics &
glyco-technology
Flow cytometry
Optics & Laser
Technology
Microscopy
Fluorescence
spectroscopy
In Vivo diagnosis
Imaging
Technology
MRI
Image-guided
therapy
PET
CAT
Ultrasound
Informatics
Resources
Genetics
Modeling of
complex systems
Molecular
dynamics
Visualization
Imaging
informatics
Biomedical Technology Research Centers (BTRCs)
NCRR
Division of Research Infrastructure Centers
Research Centers in Minority Institutions (RCMI)
IDeA Networks of Biomedical Research Excellence (INBRE)
Centers of Biomedical Research Excellence (COBRE)
NCRR
Improve the way biomedical research is
conducted across the country
Reduce the time it takes for laboratory
discoveries to become treatments for patients
Engage communities in clinical research efforts
Train a new generation of clinical and
translational researchers
Led by the National Center for Research Resources
the CTSA program supports a national consortium
of medical research institutions that work together
and share a common vision to:
www.CTSAWeb.org
Goals of the CTSA Program
NCRR
Building a National CTSA Consortium 46 CTSA sites in 26 states;60 sites when fully implemented
WA
OR
CA
NV
AZ
NM
MT
UT
WY
CO
SD
ND
NE
KS
OK
TXAK
AR
MO
IA
MN
WI
IL IN
MI
OH
KY
TN
MS AL GA
FL
LA
NC
SC
VAWV
PA
NY
VTNH
ME
MA
DEMD
RI
ID
HI
PR
NJ
= IDeA-Eligible State and CTSA Member
= CTSA State
= IDeA-Eligible States
NCRR
Clinical and Translational Science Awards (CTSA)
Training
LicensingBusiness
Informatics
Pilot Projects
Regulatory Support, Biostatistics, Trial Design
Participant and Community Engagement
Clinical Resources and Ethics
NCRR
Training Clinical and Translational Scientists
CTSA Education and Career Development Committee
Developed in partnership with CTSA institutions, NIH, other
government agencies and industry
Core Competencies in Clinical and Translational Research
Topics teach students how to:
Move basic discoveries through the patent process
Work with technology transfer offices
Explore opportunities with venture capital companies to
initiate commercialization
TL1 and KL2 Awards
NCRR
Public-Private Partnerships (PPP) Example:
The West Coast Licensing Partnership
Adds value by bundling related technologies over individual tools and technologies
Strengthens inter-institutional relationships between member partners
Increases global access to research tools by promotion of non-exclusive licensing
Provides simple one-stop licensing of technologies from multiple institutions
Saves time and money from negotiating multiple license agreements
Oregon CTSA is part of a group of institutions willing to designate a subset of their technologies for marketing and licensing purposes
NCRR
CTSA Consortium – Building Connections with Business Schools
Develop business plans, design, and implement community
surveys
Create innovative cross-educational programs
Develop case studies to pilot programs
Collaborate with international colleagues
Prepare cost analyses
Protect CTSA-developed patents
Form industry partnership programs
CTSA are partnering with business schools to:
NCRR
Resource Networking and Collaboration Vanderbilt Institute for Clinical and Translational Research
StarBRITE
web-based portal
which provides
“one-stop”
shopping for
research needs
Currently
authorized users
only
ResearchMatch
National recruitment
Registry
Centralized, disease-
neutral Web portal to
connect researchers to
research volunteers
Includes over 37 CTSAs
REDCap
Web-based tools
that support data
capture and
dissemination for
clinical and
translational
research
Leader in patient recruitment and research resource software
development
NCRR
Two Web-based initiatives bring power of Internet-based tools,
exemplified by social networking to biomedical research
Harvard Medical School
eagle-i: Networking Research Resources Across America
Will create a federated national informatics network
9 institutions participating
Goal is to enable any investigator across America to discover research
resources that are presently invisible
University of Florida
VIVO: Enabling National Networking of Scientists
Will create a social network to enable connections among the scientific
community and create pathways that lead to others they know
6 institutions participating
Resource Networking and Collaboration through
NCRR Recovery Act (ARRA) Funds
www.ncrr.nih.gov/u24
NCRR
CTSA Pilot Projects with DCM
Fund pilot projects aimed at creating new and/or strengthening interactions between NCRR supported ABMRs and nationally-oriented clinical and translational research institutions (e.g. CTSAs, Research Centers in Minority Institutions Infrastructure for Clinical and Translational Research)
Identify and support collaborative research interactions that would be competitive for future research funding
Funded awards in 2009
Funding Opportunity RFA-RR-08-011
Revision Award Mechanism for Support of Animal and Biological
Materials Resources (ABMR) to Develop Translational Pilot Projects
with Investigators at Clinical and Translational Research Institutions
(P40, P51, U42)
NCRR
CTSA – Providing Local Leveraging Opportunities
Yerkes National PrimateResearch Center
Kaiser PermanenteGeorgia
Atlanta VAMedical Center
Complex Carbohydrate Research Center
at U GeorgiaGeorgia Bio
Georgia Research Alliance
Emory University
MorehouseSchool of Medicine
CDC
GeorgiaTech
Children’sHealthcareof Atlanta
Atlanta Clinical and Translational Science Institute (Atlanta-CTSI)
at Emory University
NCRR
Interactions with Government, Industry and Academia
University of Pennsylvania CTSA Example
http://www.itmat.upenn.edu/ctsa/caep/index.shtml
Exploring business practices and best
management models in developing
collaborations in the pre-competitive
space
Looking to develop workgroups to
address barriers to collaboration
Engaging both the private and non-
profit sector to identify gaps and
opportunities for partnership and
collaboration with CTSA institutions.
Commercialization and
Entrepreneurship Program (CAEP)
NCRR
2010 Opportunities for Research and NIH Francis Collins, Director, NIH
Benefiting health care reform
Focusing on global health
1 January 2010 Vol 327
Science, Issue 5961,
Pages 36-37
Applying high throughput technologies
Translating basic science discoveries
into new and better treatments
Reinvigorating and empowering the
biomedical research community