We will begin momentarily at 2pm ET2014/10/22 · We will begin momentarily at 2pm ET Slides...

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We will begin momentarily at 2pm ET

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Thursday, October 30, 2014

“The Future of Drug Discovery:

Challenges, Risks, and Rewards”

Dr. Richard Connell, VP of Ext. Research Solutions, Pfizer

Dr. Jeff Zablocki, Senior Director, Gilead Sciences

Thursday, November 6, 2014

“Cannabis Chemistry 201”

Dr. Christopher Hudalla, Chief Scientific Officer, ProVerde

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Dr. Jeff Kiplinger, President & CEO, Averica Discovery Services

“Planet of Viruses”

This ACS Webinar is co-produced with the National Chemistry Week 2014

www.acs.org/acswebinars Recordings will be available to ACS members after three weeks

Beth Hamelin Chemist, Centers for Disease

Control and Prevention

Carl Zimmer New York Times Journalist and Author,

Fellow, Yale University

A Planet of Viruses

Carl Zimmer

American Chemical Society Webinar,

October 23, 2014

nbcnews.com

http://news.nationalgeographic.com news.nationalgeographic.com/news/2014/09/140925-mapping-the-spread-of-ebola/

As of October 14: 8914 cases, 4447 deaths (CDC)

Ebolavirus

cdc.gov

Ebola virus (blue) emerging from an infected cell

(yellow)

NIAID flic.kr/p/o15Y5n

First documented in 1976; 2998 deaths

in all Ebola outbreaks before 2014.

Franquet's Epauletted Bat

(Epomops franqueti)

Photo by Jakob Fahr

inaturalist.org/taxa/40804-

Epomops-franqueti

Olival and Hayman, Viruses 2014, 6(4), 1759-1788;

Which of the following viruses have been responsible for the most deaths?

Audience Survey Question

• HIV

• Influenza

• Smallpox

• Ebola

• YouTube’s Viral Videos

Ebola: 7,445 deaths ever

Area proportional to number of deaths

Ebola: 7,445 deaths ever

Influenza: over 250,000 deaths per year

HIV: 1.6 million deaths per year

Smallpox: ~ 5 million deaths

per year in the 20th century

Where do viruses come from?

From Zimmer,

The Tangled

Bank (Second

Edition)

Faria et al Science 3 October 2014: 346:56-61

Cave of Crystals, Mexico

Erik K. Veland http://www.flickr.com/photos/16346469@N00/437201319

https://picasaweb.google.com/zichali

Vostok

http://www.flickr.com/photos/nsf_beta/4514670771/

Yau et al, PNAS 2011 108:15 6163-6168

Our inner ecology

How many viruses are there?

Approximately, how many viruses are there?

Audience Survey Question

• Trillions (12 zeros)

• Quintillions (18 zeros)

• Sextillions (21 zeros)

• Octillions (27 zeros)

• Nonillions (30 zeros)

How many viruses are there?

Answer: 10000000000000000000000000000000

200,000,000

light years

Distance: Hendrix, Advances in

Virus Research 2005 64:1

Time to surrender?

Smallpox

World Health Organization Pharaoh Ramses V

Edward Jenner

Wikipedia

Rabies: 69,000 deaths a year

Lankester et al Science 2014 345:1562-1564

web.stanford.edu/virus

Lankester et al Science 2014 345:1562-1564

Get ahead of the next outbreak

Guinea deforestation

http://elifesciences.org/content/3/e04395

The Real Hot Zone

Use viruses as

medical tools

Tree-top Disease

Bill Tyne

http://www.flickr.com/photos/85265584@N00/

2288300863

ent.iastate.edu/dept/faculty/bonningb/fil

es/images/baculovirus.jpg

See Hoover et al, Science 2011 333:1401

Baculovirus

From Tree-top Disease to Flu Vaccine

Flublok (Protein Sciences)

Use viruses to fight other diseases

David Vetter, a boy with

X-linked severe combined immunodeficiency

Murine Leukemia Virus

MicrobeWiki

See Hacein-Bey-Abina et al N Engl J Med 2014; 371:1407-1417

Gene therapy

See Hacein-Bey-Abina et al N Engl J Med 2014; 371:1407-1417

For more

information, visit

carlzimmer.com

Laboratories

Be a featured fan on an upcoming webinar! Write to us @ acswebinars@acs.org

ACS Webinars benefit me by…

“They should advertise ACS Webinars in intro

chemistry classes for undergrads to increase an

understanding of how chemistry knowledge is

applied in the real world.”

Rachna Ram, Ph.D.

Intellectual Property Analyst

Energy Biosciences Institute

University of California at Berkeley

@acswebinars

youtube.com/acswebinars

Benefits of ACS Membership

7 www.acs.org/2joinACS

Chemical & Engineering News (C&EN) The preeminent weekly news source.

NEW! Free Access to ACS Presentations on Demand® ACS Member only access to over 1,000 presentation recordings from recent ACS meetings and select events.

NEW! ACS Career Navigator Your source for leadership development, professional education, career services, and much more.

ACS Webinars does not endorse any products or

services. The views expressed in this presentation

are those of the presenter and do not necessarily

reflect the views or policies of the American

Chemical Society.

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We will begin momentarily at 2pm ET2014/10/22 · We will begin momentarily at 2pm ET Slides...

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