ANTI MANIA

Date post:28-Mar-2015
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` MANIA-- STATE OF ELEVATED MOOD & PSYCHOMOTOR ACCELERATION, WITH EXCESS CATHECHOLAMINES ACTIVITYTREATMENT: LITHIUM CARBONATE

INDICATIONS: BIPOLAR DISORDERS THYROTOXICOSIS INAPPROPRIATE ADH SECRETION

ABSORPTION : virtually complete within 6 -8 hrs; peak plasma levels in 30 min to 2 hrs DISTRIBUTION: in total body water; slow entry into intracellular compartment. No protein binding METABOLISM: None EXCRETION: virtually entirely in urine; plasma half life is about 20 hours

`

Memblok jalur IP3 deplesi PIP2 membran menurunkan aksi transmittornya sebagai second messenger

1. 2. 3. 4. 5. 6. 7. 8.

CNS EFFECTS: dizziness, CVS EFFECTS: ventricular

mild ataxia

NEUROMUSCULAR EFECTS: fine

tremors

arrythmias GIT EFFECTS: nausea, vomiting, diarrhea GUT EFFECTS: polyuria ENDOCRINE EFFECTS: hypothyroidism ALLERGIC REACTION: pruritus, rash OVERDOSE TOXICITY: vomiting, decrease consciousness and seizures

A. MARKED DEHYDRATION OR SODIUM DEPLETION B. SIGNIFICANT RENAL OR CARDIAC DISEASES C. PREGNANCY D. RENAL CONCENTRATION ABILITY ` Nephrogenic diabetes insipidus with polyuria

A.

B. C.

THIAZIDE DIURETICS: DECREASE RENAL CLEARANCE OF LITHIUM NSAID: DECREASE LITHIUM CLEARANCE ANTIPYSCHOTIC AGENTS: INCREASE NEUROTOXICITY

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