The intelligent coater for innovative solutions

Sub-Kilogram Scale Benchtop Tablet Coater

Patent Pending

Choose the original…choose success!

INNOVATION•Coatverysmallquantitiesofcores–as few as

100 tablets•Exchangeablecoatingunitwithintegratedcoating

chamber, drum, plenum and front process port•Completeseparationofproductcontactareafrom

mechanical space•Integratedworkspaceforsolutionvessel,mixer

and scale•Closedtransfersoroff-benchloading/unloading

under containment

VERSATILITY•Aqueousfilmandsolventcoatingprocesses•Functionalandmodifiedreleasecoatings•Coatingwithoneormoredruglayers•Tablets,mini-tabsandsoftgels•Optionalexecutionforhandlingpotent

compounds

FUNCTIONALITY•Fullyperforateddrumwithanti-slidebars•Schlickspraynozzlewithanti-beardingcap•Exhausttemperaturesetpointcontrol•Independentcontrolofatomizingandpatternair•Externalspraynozzlepositioningwithcoater

door closed•Drumcapacityis5liters

USABILITY•24x36inchfootprint-fitsneatlyonstandard

laboratory bench•10-inchcolortouchscreenHMI•Frontaccessmanualsampling•Excellentvisibilitythroughfrontwindow•Easydisassemblyforcleaningatthebenchor

out-of-place•Benchtoporcart-mountedformobileapplications

At last, the wait is over… here is the benchtop coater you asked for! Inspired by our customers, and driven by innovation, Thomas Engineering presents the FLEX 05 benchtop tablet coater!

FLEX 05 is more than just a film coater – it is a practical and highly functional coating platform for most processes including

those where high weight-gain drug layers and modified release coatings are essential.

TheFLEX05coaterincludescomputer-basedcontrols,dataacquisitionandreportingfunctionsinacompactpackagewith

color touch screen HMI. Convenient and versatile, the FLEX 05 is sure to become your indispensable coater for rapid product

development, feasibility studies, and production of early stage clinical supplies – even with just a handful of tablets!

Patent Pending.Illustrations, specifications

and technical data are subject to change without notice.

Some features described in this document are optional.

FLEX 05…because tomorrow takes place on your benchtop today

Just Plug ‘n’ Process!

The FLEX 05 is an integrated tablet coating system – Tablet coating

chamber with drum and exhaust plenum, process air handling, solution

delivery and controls - in a single benchtop unit!

Operator Protection and Containment

Innovative Exchangeable Coating Unit (XCU)

Attention to Details

•FLEX05coatingplatformwithexchangeable coating units – drum, chamber, plenum and process port

•XCUisself-connectingtotheinlet/exhaust air ports and to drum drive

•Easyremovalandinstallationforfastsetups and changeovers without tools

•Integratedexhaustplenumextractswith the XCU for easy cleaning

•XCUsareinterchangeable–dedicatecoating units to drug compound families, research departments and formulation scientist groups

FLEX 05 is thoughtfully designed with the user in mind•Accurateandrepeatablegun

positioning - no other manual adjustments!

•Veryfewpartstohandleduringcleanings and project transitions

•Tool-lesssetupsandchangeovers•Convenientworkspaceforsolution

vessel, mixer and scale•Compellingaesthetics

•Coateroperatesundernegativepressure•Inflatablesealonfrontprocessport•Sanitaryflangesavailableforclosed

loading and unloading•Manualsamplingandspraynozzle

positioning with front process port closed

•Fullycontainedexecutionwithsafechange filters

One Coating Platform - Many Uses

Solution Delivery

HMI and Controls

• Processparametersaresetusingcolortouch screen HMI

• HMI-drivenmanualcontroloftheprocess with data capture

• Minimumnumberofcontrolscreensfor ease of use

• Realtimedisplayofmeasuredprocessparameters

• RealtimecalculationanddisplayofEnvironmentalEquivalency(EE)Factor using proprietary TAAC process modeling algorithm

•Peristalticpumpwithpreciseflowcontrol

•Schlick®anti-beardingspraynozzle (ABC technology) provides performance matching nozzles on production scale coaters

•Vibration-dampenedscaleforaccurate flow rate measurement

•Externalmanualpositioningofspraynozzle with coater door closed

•Nozzlepositioningmechanismwith graduated scale for repeatable nozzle-to-bed distance and angle settings

•ExchangeableCoatingUnits(XCUs)permit the FLEX 05 to be easily shared between multiple user groups

•FLEX05isacosteffectivealternativeto purchasing multiple conventional-type lab coating systems

FLEX 05…because tomorrow takes place on your benchtop today

Just Plug ‘n’ Process!

The FLEX 05 is an integrated tablet coating system – Tablet coating

chamber with drum and exhaust plenum, process air handling, solution

delivery and controls - in a single benchtop unit!

Patent Pending.Illustrations, specifications

and technical data are subject to change without notice.

Some features described in this document are optional.

Overall dimensions 24” x 36” x 30” high [610 mm x 815 mm x 760 mm]

Up to 5 liters; ½ liter with divider plate

12 in. [305 mm]

5 – 40 RPM

20 – 100 CFM (45°C maximum bed temp) [35 – 170 m3/h]

Schlick™ 970 ABC

Watson-Marlow peristaltic pump

20 – 30 psi at 4 SCFM [1.4 – 2.0 bar at 7 m3/h]

PLC and touch panel HMI

80 - 100 psi [5.4 – 6.8 bar]

230 VAC, 60 Hz, single phase; 30 amps

280 lbs. with Exchangeable Coating Unit [130 kg]240 lbs without Exchangeable Coating Unit [110 kg] The Exchangeable Coating Unit can be removed from the coating platform to be cleaned in a lab sink, in a parts washer or in a cleaning room

Drum volume

Drum diameter

Drum speed

Air flow and temperature

Spray nozzle

Solution delivery

Atomizing/Pattern air

Controls

Compressed air supply

Electrical

Weight

Cleaning

Patent Pending.Illustrations, specifications

and technical data are subject to change without notice.

Some features described in this document are optional.

INTEGRATED COATING SYSTEM•Coatingchamberwithdrumandexhaustplenum,processairhandling,solutiondeliveryandcontrols

in a single benchtop unit•Minimumspacerequirement–fitsonmostexistinglaboratorybenches•Built-inworkspaceforsolutionvesselandmixer•Single-pointconnectionsforelectricandcompressedairutilities

USER FRIENDLY•Simpletouchscreengraphicsforintuitivereferencetocoatingdevices•Singleprocesscontrolwindowfortheparametersandmeasurements•Easypositioningofspraynozzlewithouttoolsandwithoutopening

front process port•Easytouse–reducestrainingtimeandexpense

PROPRIETARY THOMAS TAAC PROGRAM•Builtintothecoaterforreal-timeassessmentofdryingconditions•Providesassistanceforprocessscale-upcalculations

PROCESS VERSATILITY•Provides“futuresafety”–helpsaccommodatenewprocessesnotyetinthedevelopmentpipeline

Features and Benefits

OptionsHEPA Filtration•Inlet and exhaust,

remote

Instrumentation upgrade package•Additional instruments

to measure inlet dew point, bed temperature and ΔP through bed

Solvent coating•Execution for Class 1,

Division 2

Containment• Operator protection

(inflatable seals) and fully contained execution with safe change filters

Drums and XCUs• Additional drums and

Exchangeable Coating Units (XCUs) are also available

FLEX 05 Specifications

Capabilities For more than 50 years, Thomas Engineering has been a partner in the solid dosage processing industry, helping customers

develop and manufacture pharmaceutical products in an efficient and cost effective manner.

With the Accela-Cota® FLEX 05, Thomas can help even more by offering an integrated tablet coating platform for small-scale

development of a range of coating processes. With the FLEX 05, our customers have an innovative tool to succeed in developing

coated products rapidly in response to market demands for new and improved drug therapies. Our customers appreciate the value of a partnership with Thomas Engineering, the market leader dedicated to coating, tablet

compression and tablet press tooling. These customers know that their investment extends beyond a system of machines and

controls – they also benefit from our expertise and competency resulting from decades of experience with tablet coating systems

in the field. The dividend is their assurance that their TEI coating system will deliver reliable performance and consistently good

finished products for many years.

Choose the original…choose success…choose Thomas Engineering.

Thomas Engineering Inc.575 West Central Road

Hoffman Estates, IL 60192T. 847/358-5800 F. 847/358-5817

www.thomaseng.com

FLEX 500

Spray technology

Patent Pending.Illustrations, specifications

and technical data are subject to change without notice.

Some features described in this document are optional.

Compu-Lab

Accela-Cota Tablet Press Tooling

Continuous Tablet Coater

Production class tablet coater with exchangeable drums, optimized design for enhanced cleanability and with features for manufacturing flexibility and process versatility. FLEX 500 is a winner of the prestigious iF Product Design Award 2010 for outstanding quality in design.

Innovative designs for process versatility

Integrated tablet coating system for R&D, pilot plant, clinical supplies and small batch manufacturing

Production class tablet coater with more than 1,200 installations world wide

Leader in the design and manufacture of punch and die tooling.

High throughput continuous processing for tablets and softgels