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Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 15 (Jul. 22, 1997), pp. i-viii Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/42742 . Accessed: 07/05/2014 08:24 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.136 on Wed, 7 May 2014 08:24:20 AM All use subject to JSTOR Terms and Conditions
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Page 1: Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 94, No. 15 (Jul. 22, 1997), pp. i-viiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/42742 .

Accessed: 07/05/2014 08:24

Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp

.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].

.

National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.

http://www.jstor.org

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Page 2: Front Matter

PROCEEDINGS

OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

July 22, 1997

Volume 94/ Number 15

INCLUDES: PAPERS FROM A NATIONAL ACADEMY OF SCIENCES COLLOQUIUM ON GENETICS AND THE ORIGIN OF SPECIES

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Page 3: Front Matter

Gene & GenSGeome Resources GENEPAIRSTM Over 16,000 gene specific,.radiationhybridmapped STS

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MAPPAIRSTM Over 22,0010 polymorphic genetic markers in twenty-four different spcies.

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Page 4: Front Matter

PROCEEDINGS OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

Officers of the Academy

Editor-in-Chief

Editorial Board of the Proceedings

BRUCE ALBERTS, President JACK HALPERN, Vice President PETER H. RAVEN, Home Secretary F. SHERWOOD ROWLAND, Foreign Secretary RONALD L. GRAHAM, Treasurer

NICHOLAS R. COZZARELLI

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PIERRE C. HOHENBERG

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ROGER KORNBERG

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PHIL W. MAJERUS

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ARNO G. MOTULSKY

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Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA (via U.S. postal service) or 1055 Thomas Jefferson Street, NW, Suite FO2013, Washington, DC 20007 USA (via courier or express mail). Information for Authors: See pp. xii and xiii (of this issue) or http://www.pnas.org. Copyright: Volumes 90-94, copyright (? 1993-1997 by the National Academy of Sciences; Volumes 1-89, copyright as a collective work only with copyright to individual articles retained by the author(s). Requests for permission to reproduce all or parts of individual articles published in Volumes 1-89 should be addressed to the authors. The journal is registered with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA, FAX 508-750-4744. Microforms of complete volumes may be obtained from University Microfilms Inc., P.O. Box 1346, Ann Arbor, MI 48106-1346 USA. This journal is printed on acid-free paper effective with Volume 84, Issue 1.

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Page 5: Front Matter

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Page 6: Front Matter

PROCEEDINGS

OF THE

NATIONAL ACADEMY OF SCIENCES

OF THE UNITED STATES OF AMERICA

July 22, 1997 Volume 94, Number 15 pp. 7691-8272

Table of Contents

Papers from a National Academy of Sciences Colloquium on Genetics and the Origin of Species

Genetics and the origin of species: An introduction 7691-7697 Francisco J. Ayala and Walter M. Fitch

Origin of Genes 7698-7703 Walter Gilbert, Sandro J. de Souza, and Manyuan Long

Transposable elements as sources of variation in 7704-7711 animals and plants

Margaret G. Kidwell and Damon Lisch

Long term trends in the evolution of H(3) HAI 7712-7718 human influenza type A

Walter M. Fitch, Robin M. Bush, Catherine A. Bender, and Nancy J. Cox

Genes, peoples, and languages 7719-7724 L. Luca Cavalli-Sforza

DNA variation at the Sod locus of Drosophila 7725-7729 melanogaster: An unfolding story of natural selection

Richard R. Hudson, Alberto G. Saez, and Francisco J. Ayala

Neutral behavior of shared polymorphism 7730-7734 Andrew G. Clark

Divergent and conserved features in the spatial 7735-7741 expression of the Drosophila pseudoobscura esterase-5B gene and the esterase-6 gene of Drosophila melanogaster

Natalia A. Tamarina, Michael Z. Ludwig, and Rollin C. Richmond

A demographic approach to selection 7742-7747 Wyatt W. Anderson and Takao K. Watanabe

Phylogenetics and the origin of species 7748-7755 John C. Avise and Kurt Wollenberg

Assortative fertilization in Drosophila 7756-7760 Therese Ann Markow

Incipient species formation in salamanders of the 7761-7767 Ensatina complex

David B. Wake

Genetics and the origin of bird species 7768-7775 Peter R. Grant and B. Rosemary Grant

Vagaries of the molecular clock 7776-7783 Francisco J. Ayala

Evolution of codon usage bias in Drosophila 7784-7790 Jeffrey R. Powell and Etsuko N. Moriyama

The evolution of plant nuclear genes 7791-7798 Michael T. Clegg, Michael P. Cummings, and Mary L. Durbin

iii

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Page 7: Front Matter

Contents

Evolution by the birth-and-death process in multigene 7799-7806 families of the vertebrate immune system

Masatoshi Nei, Xun Gu, and Tatyana Sitnikova

Perspective

The radioactivity of atmospheric krypton in 7807-7810 1949-1950

Anthony Turkevich, Lester Winsberg, Howard Flotow, and Richard M. Adams

Review

Immunity to retroviral infection: The Friend 7811-7816 virus model

Kim J. Hasenkrug and Bruce Chesebro

Physical Sciences

APPLIED MATHEMATICS

Structure of the zero-pressure-gradient turbulent 7817-7819 boundary layer

G. I. Barenblatt, A. J. Chorin, 0. H. Hald, and V. M. Prostokishin

APPLIED PHYSICAL SCIENCES

Phosphorylation and subunit organization of axonal 7820-7824 neurofilaments determined by scanning transmission electron microscopy

R. D. Leapman, P. E. Gallant, T. S. Reese, and S. B. Andrews

CHEMISTRY

Inducible gene expression and protein translocation 7825-7830 using nontoxic ligands identified by a mammalian three-hybrid screen

Stephen D. Liberles, Steven T. Diver, David J. Austin, and Stuart L. Schreiber

Virtual combinatorial libraries: Dynamic generation of 8272 molecular and supramolecular diversity by self-assembly (Correction)

Ivan Huc and Jean-Marie Lehn

Biological Sciences

BIOCHEMISTRY

Association of the mammalian helicase MAH with the 7831-7836 pre-mRNA splicing complex

Gyongyi M. Molnar, Anne Crozat, Stine-Kathrein Kraeft, Qing Ping Dou, Lan Bo Chen, and Arthur B. Pardee

Helical repeat of DNA in the region 7837-7840 of homologous pairing

Konstantin Kiianitsa and Andrzej Stasiak

Allosteric intermediates indicate R2 is the liganded 7841-7844 hemoglobin end state

Maria A. Schumacher, Ekaterina E. Zheleznova, Kitty S. Poundstone, Ronald Kluger, Richard T. Jones, and Richard G. Brennan

Total chemical synthesis of enzymatically active 7845-7850 human type II secretory phospholipase A2

Tilman M. Hackeng, Carine M. Mounier, Cassian Bon, Philip E. Dawson, John H. Griffin, and Stephen B. H. Kent

A DnaB intein in Rhodothermus marinus: Indication 7851-7856 of recent intein homing across remotely related organisms

Xiang-Qin Liu and Zhuma Hu

X-ray structures of a hydrolytic antibody and of 7857-7861 complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release

Benoit Gigant, Jean-Baptiste Charbonnier, Zelig Eshhar, Bernard S. Green, and Marcel Knossow

Direct involvement of the ubiquitin-conjugating 7862-7867 enzyme Ubc9/Hus5 in the degradation of IKBa

Kei Tashiro, Matthew P. Pando, Yumi Kanegae, Penny M. Wamsley, Satoshi Inoue, and Inder M. Verma

The p53 tumor suppressor targets a novel regulator of 7868-7872 G protein signaling

Leonard Buckbinder, Susana Velasco-Miguel, Yan Chen, Ningzhi Xu, Randy Talbott, Larry Gelbert, Jizong Gao, Bernd R. Seizinger, J. Silvio Gutkind, and Nikolai Kley

Human and Saccharomyces cerevisiae dolichol 7873-7878 phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe

Paul A. Colussi, Christopher H. Taron, Jamey C. Mack, and Peter Orlean

Steroid receptor induction of gene transcription: A 7879-7884 two-step model

Guido Jenster, Thomas E. Spencer, Mark M. Burcin, Sophia Y. Tsai, Ming-Jer Tsai, and Bert W. O'Malley

a-Tocopheryl hydroquinone is an efficient 7885-7890 multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids

Jiri Neuzil, Paul K. Witting, and Roland Stocker

The herpes simplex virus 1 protein kinase Us3 is 7891-7896 required for protection from apoptosis induced by the virus

Rosario Leopardi, Charles Van Sant, and Bernard Roizman

The major yeast poly(A)-binding protein is associated 7897-7902 with cleavage factor IA and functions in premessenger RNA 3'-end formation

Lionel Minvielle-Sebastia, Pascal J. Preker, Thomas Wiederkehr, Yvan Strahm, and Walter Keller

iv

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Page 8: Front Matter

Contents

Leishmania tarentolae contains distinct cytosolic and 7903-7908 mitochondrial glutaminyl-tRNA synthetase activities

Christoph E. Nabholz, Remy Hauser, and Andre Schneider

Activation of the orphan receptor RIP14 by retinoids 7909-7914 Ann Marie Zavacki, Jiirgen M. Lehmann, Wongi Seol, Timothy M. Willson, Steven A. Kliewer, and David D. Moore

The Xenopus proglucagon gene encodes novel 7915-7920 GLP-1-like peptides with insulinotropic properties

David M. Irwin, Malathy Satkunarajah, Yi Wen, Patricia L. Brubaker, Raymond A. Pederson, and Michael B. Wheeler

Targeted inactivation of ai2 or ai3 disrupts activation 7921-7926 of the cardiac muscarinic K+ channel, IK+Ach, in intact cells

Margaret 0. Sowell, Chianping Ye, Dennis A. Ricupero, Sherry Hansen, Stephen J. Quinn, Peter M. Vassilev, and Richard M. Mortensen

BIOPHYSICS

Detection of single-molecule interactions using 7927-7931 correlated thermal diffusion

A. D. Mehta, J. T. Finer, and J. A. Spudich

Nonexponential kinetics of a single tRNAPhe molecule 7932-7936 under physiological conditions

Yiwei Jia, Alexander Sytnik, Liangquan Li, Serguei Vladimirov, Barry S. Cooperman, and Robin M. Hochstrasser

Microsecond atomic force sensing of protein 7937-7941 conformational dynamics: Implications for the primary light-induced events in bacteriorhodopsin

Itay Rousso, Edward Khachatryan, Yahaloma Gat, Igor Brodsky, Michael Ottolenghi, Mordechai Sheves, and Aaron Lewis

Kinetic theory of fibrillogenesis of amyloid ,3-protein 7942-7947 Aleksey Lomakin, David B. Teplow, Daniel A. Kirschner, and George B. Benedek

CELL BIOLOGY

Phosphorylation and subunit organization of axonal 7820-7824 neurofilaments determined by scanning transmission electron microscopy

R. D. Leapman, P. E. Gallant, T. S. Reese, and S. B. Andrews

Inducible gene expression and protein translocation 7825-7830 using nontoxic ligands identified by a mammalian three-hybrid screen

Stephen D. Liberles, Steven T. Diver, David J. Austin, and Stuart L. Schreiber

Nuclear localization of basonuclin in human 7948-7953 keratinocytes and the role of phosphorylation

Shiro luchi and Howard Green

Tumor induction by a transformation-defective 7954-7958 polyoma virus mutant blocked in signaling through Shc

Roderick Bronson, Clyde Dawe, John Carroll, and Thomas Benjamin

Transmembrane/cytoplasmic domain-mediated 7959-7964 membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

Hirokazu Nakahara, Linda Howard, Erik W. Thompson, Hiroshi Sato, Motoharu Seiki, Yunyun Yeh, and Wen-Tien Chen

The Schizosaccharomyces pombe spindle checkpoint 7965-7970 protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex

Xiangwei He, Thomas E. Patterson, and Shelley Sazer

Roles of phospholipase C /32 in chemoattractant- 7971-7975 elicited responses

Huiping Jiang, Yanan Kuang, Yanping Wu, Wei Xie, Melvin I. Simon, and Dianqing Wu

DEVELOPMENTAL BIOLOGY

An upstream, DNase I hypersensitive region of the 7976-7981 hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice

Michael A. McDevitt, Yuko Fujiwara, Ramesh A. Shivdasani, and Stuart H. Orkin

An important developmental role for oligosaccharides 7982-7986 during early embryogenesis of cyprinid fish

Jeroen Bakkers, Carlos E. Semino, Henri Stroband, Jan W. Kijne, Phillips W. Robbins, and Herman P. Spaink

EVOLUTION

Phylogeny of the genus Pistacia as determined from 7987-7992 analysis of the chloroplast genome

Dan E. Parfitt and Maria L. Badenes

An upper dentition of Aframonius dieides (Primates) 7993-7996 from the Fayum, Egyptian Eocene

Elwyn L. Simons and Ellen R. Miller

Functional and nonfunctional mutations distinguished 7997-8000 by random recombination of homologous genes

Huimin Zhao and Frances H. Arnold

Cleavage patterns and the topology of the metazoan 8001-8005 tree of life

James W. Valentine

Molecular evidence that echiurans and 8006-8009 pogonophorans are derived annelids

Damhnait McHugh

GENETICS

Cloning and characterization of hOGGl, a human 8010-8015 homolog of the OGG1 gene of Saccharomyces cerevisiae

J. Pablo Radicella, Claudine Dherin, Chantal Desmaze, Maurice S. Fox, and Serge Boiteux

v

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Page 9: Front Matter

Contents

Molecular cloning and functional expression of a 8016-8020 human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

Teresa Roldan-Arjona, Ying-Fei Wei, Kenneth C. Carter, Arne Klungland, Catherine Anselmino, Rui-Ping Wang, Meena Augustus, and Tomas Lindahl

Isolation of full-length ATM cDNA and correction of 8021-8026 the ataxia-telangiectasia cellular phenotype

Ning Zhang, Philip Chen, Kum Kum Khanna, Shaun Scott, Magtouf Gatei, Sergei Kozlov, Dianne Watters, Kevin Spring, Tim Yen, and Martin F. Lavin

Transitions in the coupling of transcription and 8027--8032 nucleotide excision repair within RNA polymerase II-transcribed genes of Saccharomyces cerevisiae

Marcel Tijsterman, Richard A. Verhage, Pieter van de Putte, Judith G. Tasseron-de Jong, and Jaap Brouwer

The one ancestor per generation rule and three other 8033-8035 rules of mitochondrial inheritance

Susumu Ohno

Synergistic and promoter-selective activation of 8036-8041 transcription by recruitment of transcription factors TFIID and TFIIB

Eduardo Gonzalez-Couto, Natacha Klages, and Michel Strubin

Retention of replication fidelity by a DNA polymerase 8042-8046 functioning in a distantly related environment

Holly Kloos Dressman, Chien-Chia Wang, Jim D. Karam, and John W. Drake

Fusion genes resulting from alternative chromosomal 8047-8051 translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma

Richard J. Davis and Frederic G. Barr

High genetic instability of heterochromatin after 8052-8057 transposition of the LINE-like I factor in Drosophila melanogaster

Patrizio Dimitri, Bruno Arca, Libera Berghella, and Elisabetta Mei

The hotspot conversion paradox and the evolution of 8058-8063 meiotic recombination

Alan Boulton, Richard S. Myers, and Rosemary J. Redfield

IMMUNOLOGY

Direct delivery of exogenous MHC class I 8064-8069 molecule-binding oligopeptides to the endoplasmic reticulum of viable cells

Patricia M. Day, Jonathan W. Yewdell, Angel Porgador, Ronald N. Germain, and Jack R. Bennink

A single peripheral CD8+ T cell can give rise to 8070-8075 progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions

Anne Kelso and Penny Groves

Ku7O-deficient embryonic stem cells have increased 8076-8081 ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

Yansong Gu, Shengfang Jin, Yijie Gao, David T. Weaver, and Frederick W, Alt

Identification of immunodominant T cell epitopes of 8082-8087 human glutamic acid decarboxylase 65 by using HLA-DR(a1 *0101,31 *0401) transgenic mice

Salil D. Patel, Andrew P. Cope, Mauro Congia, Teddy T. Chen, Eugene Kim, Lars Fugger, Diane Wherrett, and Grete Sonderstrup-McDevitt

Natural killer cell acceptance of H-2 mismatch bone 8088-8092 marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor (CD158b)

Anna Cambiaggi, Christophe Verthuy, Philippe Naquet, FranGois Romagne, Pierre Ferrier, Roberto Biassoni, Alessandro Moretta, Lorenzo Moretta, and Eric Vivier

Characterization of tumor necrosis 8093-8098 factor-deficient mice

Michael W. Marino, Ashley Dunn, Dianne Grail, Melissa Inglese, Yuji Noguchi, Elizabeth Richards, Achim Jungbluth, Hisashi Wada, Malcolm Moore, Barbara Williamson, Sunanda Basu and Lloyd J. Old

MEDICAL SCIENCES

Manipulation of T cell costimulatory and inhibitory 8099-8103 signals for immunotherapy of prostate cancer

Eugene D. Kwon, Arthur A. Hurwitz, Barbara A. Foster, Christopher Madias, Andrew L. Feldhaus, Norman M. Greenberg, Maurice B. Burg, and James P. Allison

Hypoxia-inducible factor-I modulates gene expression 8104-8109 in solid tumors and influences both angiogenesis and tumor growth

P. H. Maxwell, G. U. Dachs, J. M. Gleadle, L. G. Nicholls, A. L. Harris, I. J. Stratford, 0. Hankinson, C. W. Pugh, and P. J. Ratcliffe

Modified cytokeratins expressed on the surface of 8110-8115 carcinoma cells undergo endocytosis upon binding of human monoclonal antibody and its recombinant Fab fragment

Henrik J. Ditzel, Ursula Garrigues, Claus B. Andersen, Morten K. Larsen, H. Jacques Garrigues, Arne Svejgaard, Ingegerd Hellstr6m, Karl Erik Hellstr6m, and Jens C. Jensenius

Tat protein induces self-perpetuating permissivity for 8116-8120 productive HIV-1 infection

Chiang J. Li, Yutaka Ueda, Bin Shi, Laura Borodyansky, Lili Huang, You-Zhi Li, and Arthur B. Pardee

Transgenic Gagq overexpression induces cardiac 8121-8126 contractile failure in mice

Drew D. D'Angelo, Yoshihito Sakata, John N. Lorenz, Gregory P. Boivin, Richard A. Walsh, Stephen B. Liggett, and Gerald W. Dorn II

vi

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Page 10: Front Matter

Contents

Macrophages lacking scavenger receptor A show a 8127-8131 decrease in binding and uptake of acetylated low-density lipoprotein and of apoptotic thymocytes, but not of oxidatively damaged red blood cells

Valeska Terpstra, Nonna Kondratenko, and Daniel Steinberg

Altered expression of the WT1 Wilms tumor 8132-8137 suppressor gene in human breast cancer

Gary B. Silberstein, Katharine Van Horn, Phyllis Strickland, Charles T. Roberts, Jr., and Charles W. Daniel

Mouse model of GM2 activator deficiency manifests 8138-8143 cerebellar pathology and motor impairment

Yujing Liu, Alexander Hoffmann, Alexander Grinberg, Heiner Westphal, Michael P. McDonald, Katherine M. Miller, Jacqueline N. Crawley, Konrad Sandhoff, Kinuko Suzuki, and Richard L. Proia

Thymineless death in colon carcinoma cells is 8144-8149 mediated via Fas signaling

Janet A. Houghton, Franklin G. Harwood, and David M. Tillman

The antisense bcl-2-IgH transcript is an optimal target 8150-8155 for synthetic oligonucleotides

Susanna Morelli, Domenico Delia, Sergio Capaccioli, Alessandro Quattrone, Nicola Schiavone, Anna Bevilacqua, Silvia Tomasini, and Angelo Nicolin

Growth arrest of Epstein-Barr virus immortalized B 8156-8161 lymphocytes by adenovirus-delivered ribozymes

Shuang Huang, Dwayne Stupack, Patricia Mathias, Yibing Wang, and Glen Nemerow

The CAG repeat within the androgen receptor gene 8272 and its relationship to prostate cancer (Correction)

Edward Giovannucci, Meir J. Stampfer, Krishna Krithivas, Myles Brown, Adam Brufsky, James Talcott, Charles H. Hennekens, and Philip W. Kantoff

MICROBIOLOGY

The hepatitis B virus X gene induces p53-mediated 8162-8167 programmed cell death

Paolo Chirillo, Sabrina Pagano, Gioacchino Natoli, Pier Lorenzo Puri, Vito Lelio Burgio, Clara Balsano, and Massimo Levrero

Gene expression from plasmids containing the 8168-8172 araBAD promoter at subsaturating inducer concentrations represents mixed populations

Deborah A. Siegele and James C. Hu

NEUROBIOLOGY

Acetylcholinesterase-transgenic mice display 8173-8178 embryonic modulations in spinal cord choline acetyltransferase and neurexin 1f3 gene expression followed by late-onset neuromotor deterioration

Christian Andres, Rachel Beeri, Alon Friedman, Efrat Lev-Lehman, Sivan Henis, Rina Timberg, Moshe Shani, and H-ermona Soreq

Intracisternal basic fibroblast growth factor enhances 8179-8184 functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction

Takakazu Kawamata, W. Dalton Dietrich, Timothy Schallert, Jeffrey E. Gotts, Robert R. Cocke, Larry I. Benowitz, and Seth P. Finklestein

Expression and activation of SH2/PTB-containing 8185-8190 ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain

Luciano Conti, Claudio De Fraja, Massimo Gulisano, Enrica Migliaccio, Stefano Govoni, and Elena Cattaneo

Brain-derived neurotrophic factor rapidly enhances 8191-8195 phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1

Piin-Chau Suen, Kuo Wu, Eric S. Levine, Howard T. J. Mount, Jia-Ling Xu, Siang-Yo Lin, and Ira B. Black

Disruption of hippocampal development in vivo by 8196-8201 CR-50 mAb against Reelin

Kazunori Nakajima, Katsuhiko Mikoshiba, Takaki Miyata, Chikako Kudo, and Masaharu Ogawa

Fixation of allosteric states of the nicotinic 8202-8207 acetylcholine receptor by chemical cross-linking

Anke Watty, Christoph Methfessel, and Ferdinand Hucho

Interaction between amyloid precursor protein and 8208-8213 presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

Weiming Xia, Jimin Zhang, Ruth Perez, Edward H. Koo, and Dennis J. Selkoe

Opioid receptors from a lower vertebrate (Catostomus 8214-8219 commersoni): Sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRKI), and evolution

Mark G. Darlison, Florian R. Greten, Robert J. Harvey, Hans-Jiirgen Kreienkamp, Thorsten Stiihmer, Henk Zwiers, Karl Lederis, and Dietmar Richter

PHARMACOLOGY

Functionally differentiating two neuronal nitric oxide 8220-8225 synthase isoforms through antisense mapping: Evidence for opposing NO actions on morphine analgesia and tolerance

Yuri A. Kolesnikov, Ying-Xian Pan, Anna-Marie Babey, Subash Jain, Roger Wilson, and Gavril W. Pasternak

Nitrergic control of peripheral sympathetic responses 8226-8231 in the human corpus cavernosum: A comparison with other species

Selim Cellek and Salvador Moncada

Quantitative trait loci controlling halothane sensitivity 8232-8237 in Caenorhabditis elegans

Bruno van Swinderen, David R. Shook, Robert H. Ebert, Vera A. Cherkasova, Thomas E. Johnson, Robert J. Shmookler Reis, and C. Michael Crowder

vii

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Page 11: Front Matter

Contents

PHYSIOLOGY

Specific requirement of putrescine for the mitogenic 8238-8242 action of juvenile hormone on adult insect neuroblasts

Myriam Cayre, Colette Strambi, Pierre Charpin, Roger Augier, and Alain Strambi

PLANT BIOLOGY

AtMRPl gene of Arabidopsis encodes a glutathione 8243-8248 S-conjugate pump: Isolation and functional definition of a plant ATP- binding cassette transporter gene

Yu-Ping Lu, Ze-Sheng Li, and Philip A. Rea

Cloning of a polycistronic cDNA from tomato 8249-8254 encoding y-glutamyl kinase and y-glutamyl phosphate reductase

Mario Garcia-Rios, Tomomichi Fujita, P. Christopher LaRosa, Robert D. Locy, Jean M. Clithero, Ray A. Bressan, and Laszlo N. Csonka

Inheritance, gene expression, and lignin 8255-8260 characterization in a mutant pine deficient in cinnamyl alcohol dehydrogenase

John J. MacKay, David M. O'Malley, Timothy Presnell, Fitzgerald L. Booker, Malcolm M. Campbell, Ross W. Whetten, and Ronald R. Sederoff

Nontarget DNA sequences reduce the transgene 8261-8266 length necessary for RNA-mediated tospovirus resistance in transgenic plants

Sheng-Zhi Pang, Fuh-Jyh Jan, and Dennis Gonsalves

Social Sciences

PSYCHOLOGY

Integration of local pattern elements into a global 8267-8271 shape in human vision

Jukka Saarinen, Dennis M. Levi, and Bridgitte Shen

AUTHOR INDEX ix-xi

INFORMATION FOR AUTHORS xii-xiii

SIZING WORKSHEET xiv

COPYRIGHT ASSIGNMENT FORM xv

CLASSIFIED ADVERTISEMENTS xvi-xvii

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