Front Matter Source: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 15 (Jul. 21, 1998), pp. i-x Published by: National Academy of Sciences Stable URL: http://www.jstor.org/stable/45770 . Accessed: 07/05/2014 14:36 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp . JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. . National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access to Proceedings of the National Academy of Sciences of the United States of America. http://www.jstor.org This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PM All use subject to JSTOR Terms and Conditions
Transcript
Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 95, No. 15 (Jul. 21, 1998), pp. i-xPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/45770 .
Accessed: 07/05/2014 14:36
Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at .http://www.jstor.org/page/info/about/policies/terms.jsp
.JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range ofcontent in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new formsof scholarship. For more information about JSTOR, please contact [email protected].
.
National Academy of Sciences is collaborating with JSTOR to digitize, preserve and extend access toProceedings of the National Academy of Sciences of the United States of America.
http://www.jstor.org
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
Please note the following changes in the phone and fax numbers for the Editorial and Business Offices of the Proceedings, which became effective July 10, 1998.
The new numbers are as follows:
Main phone: 202-334-2672 Editorial fax: 202-334-2739 Business fax: 202-334-2738
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
Experts Providing AnswersTM We've been investigating issues and advising the nation for more than a
century on key questions of science, technology, and public health.
From vaccines for life-threatening diseases to improvements in automotive
safety, science provides solutions for many of today's perplexing problems.
Now there's a place where you can find our authoritative analyses, free of charge
on the web.
L.~iLL I\ ..rtr~N~A
I " | | " " " | | , " I 4 Mare tn 1,000 bo o ks o Nlin Top~~~~~~~~~~~~~~~~~p
. . . ~ ~ ~ or thv ItDD ak .oln
BeoncDiscovery News Yighligli Maroh 31 -- EPA should redirect omne research and Ten papers from '_ maintai n an integrated study program to ensure that on Sputnik,"asym t
A4t-.fot its standards for eirborre prtiele pollution addres eamining the histor cA~d my CCXPIa, nt t -serious risks perti les pse to public future of eduction r -- A Oa& Y.,PAmptox
ealth, sagJs a new report from the National now are available oni Research Council. The agency should devote more the Resear h Council funds to stuying the tJpes of pattieles rmost likeWl fr Science, MathemD
*~t74yIo ~L4~ to be harmful to human health, theways the Eng neeri ng Educatio 0 0 ~~~~ ~~~ particles cause dama~ge, and the levels of exp ure I acl 8tuallyj receive, The most recent issui PrP I N%*- _!,Resmr h C
[FullRep l | por] NaReport highl i- Boa drd o nE Dvi ron Dment a Studes a nd Txi col ogg I acvities of the A6
cotmplex in educationNO 6k ItNo re New.] reseoreh; enginerin n i
|I Nes Archivel |envrnment antdres
C.AM M A. EVents Each year, the Nation
pte* YWednesday, April 1, 1$$8 Academy of Sciences T-iqflqb- 99Y awards to recognize
* Perinetal Tranmission of HIV (Washinton outsting chievem lution gives us t ay be the science. Nominations a framewo,k of ultimate irony that
er wad E.- unetiamdate iat tofny thAIat
* Supp y Chain I ntgration (Washington yar' wards -
- ih ih understanding that Ia nation built on
r Z?S< hangesthrough immigration finds time~ It helps us to itse If oonsistently
study the ~~~~~~~embroiled in a inoredible diverzityr debate on the of life and to see caan just how similar e onomic effeots many speoese :f eontinued reaMlv are. This immiarationr
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Officers BRUCE ALBERTS, President of the JACK HALPERN, Vice President Academy PETER H. RAVEN, Home Secretary
F. SHERWOOD ROWLAND, Foreign Secretary RONALD L. GRAHAM, Treasurer
Editor-in-Chief NICHOLAS R. COZZARELLI
Editorial Board MAY R. BERENBAUM of the PETER J. BICKEL Proceedings WILLIAM CATTERALL
ANTHONY CERAMI PIERRE CHAMBON MARSHALL H. COHEN STANLEY N. COHEN DAVID R. DAVIES HERMAN N. EISEN RAYMOND L. ERIKSON ANTHONY S. FAUCI NINA FEDOROFF
CHARLES FEFFERMAN WALTER M. FITCH JOSEPH L. GOLDSTEIN CAROL A. GROSS JACK HALPERN BERTIL HILLE PIERRE C. HOHENBERG H. ROBERT HORVITZ ALFRED G. KNUDSON ROGER KORNBERG ROBERT LANGER HARVEY F. LODISH
PHIL W. MAJERUS PHILIPPA MARRACK RICHARD D. MCKELVEY ARNO G. MOTULSKY RONALD L. PHILLIPS THOMAS D. POLLARD STANLEY B. PRUSINER CHARLES RADDING GIAN-CARLO ROTA JEREMY A. SABLOFF PAUL R. SCHIMMEL STUART L. SCHREIBER
AARON J. SHATKIN CARLA J. SHATZ KAI L. SIMONS CHRISTOPHER A. SIMS SOLOMON H. SNYDER CHRISTOPHER R. SOMERVILLE LARRY R. SQUIRE CHARLES F. STEVENS FRANK H. STILLINGER KARL K. TUREKIAN DON C. WILEY PETER G. WOLYNES
Publisher: KENNETH R. FULTON Managing Editor: DIANE M. SULLENBERGER Associate Editorial Manager: JOHN M. MALLOY Associate Manager for Production: JOANNE D'AMIco Production Coordinator: BARBARA A. BACON Editorial Coordinators: AZADEH FULLMER, DANIEL H. SALSBURY
Manuscript Coordinator: JESSAMINE PRICE Editorial Assistant: RENITA M. JOHNSON
System Administrator: MARILYN J. MASON Financial Manager: JOSEPH F. RZEPKA, JR. Financial Assistant: JULIA A. LITTLE
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is published biweekly by THE NATIONAL ACADEMY OF SCIENCES.
Correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA (via U.S. postal service) or 1055 Thomas Jefferson Street, NW, Suite FO2013, Washington, DC 20007 USA (via courier or express mail). E-mail: [email protected].
Information for Authors: See pp. xiv-xvi (of this issue) or www.pnas.org.
Copyright: Volumes 90-95, copyright (C 1993-1998 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, all rights reserved; Volumes 1-89, copyright as a collective work only [author(s) retains copyright to individual articles]. Requests for Permission: Address requests to reproduce material published in Volumes 1-89 to the original author(s); address other requests to the Permissions Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA, FAX 202-334-2739. Please cite the exact material to be reprinted and state specifically where it will be used. Photocopies: The journal is registered with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 USA, FAX 978-750-4470. Authorization to photocopy items for the internal or personal use of specific clients is granted by THE NATIONAL ACADEMY OF SCIENCES provided that the copier pays to the Center the fee stated in the code on the first page of each article. Microforms: Contact University Microfilms Inc., P.O. Box 1346, Ann Arbor, MI 48106-1346 USA. This journal is printed on acid-free paper effective with Volume 84, Issue 1.
Subscriptions: Address subscription correspondence to the Circulation Office of the PROCEEDINGS, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Subscriptions are entered on a calendar-year basis only. The 1998 subscription rates for print only/online only/print plus online are as follows-in the U.S.: student, $90/$50/$110; postdoctoral, $125/$50/$150; personal, $165/$100/$195; institutional, $685/$615/$820-elsewhere (print by surface mail): student, $190/$50/$210; postdoctoral, $225/ $50/$250; personal, $265/$100/$295; institutional, $785/$615/$920-elsewhere by expedited delivery at a surcharge of $320. Air mail rates available on request. Exclusive Agent for Subscribers in Japan: USACO Corporation, 13-12, Shimbashi, 1-Chome, Minato-ku, Tokyo 105 Japan. Change ofAddress: Notify the Circulation Office 6 weeks in advance and list the old and new addresses. The Academy is not responsible for nonreceipt of issues because of an improper address, unless a change of address is on file. Claims: Requests for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. Claims will not be honored for more than 2 issues per calendar year for the same subscriber. Single Copies: $30 per issue in the U.S., $40 elsewhere. Canadian GST: Registration Number R-133130880.
Advertising: Contact FASEB AdNet, 9650 Rockville Pike, Bethesda, MD 20814-3998 USA. Phone 800-43-FASEB X7103 or 301-530-7103, FAX 301-571-0683. Postmaster: Send address changes to PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, NW, Washington, DC 20418 USA. Periodicals postage paid at Washington, DC, and additional mailing offices. PRINTED IN THE USA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES is also available online at www.pnas.org.
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
40-ba ses, "Standard" (s ti ntype) purification is not eog.Yu should ~add PAGE purification and we ve mad affordable at. just $45.00.
Capillary Electrophoresis Results Full width: 11 minutes to 23 minutes Full height: 0 to 0.9 AU
Molar Purity* IDT PAGE 97% I DT Standard 64% Competitor 28%
*Full length of product divided by the sum of al/ product.
IDT PAGE Purified__
IDT Standard
Competitor
Anialysi~ of the s 40-mer sequence comparing IDT's PAGE purified synthesis" ta-4 stnadoligos from IDT and six major competitors. Please visit our web site to download a complete report.
IDT's purity standards surpas the industry's other major compet'itors.
The 40-kDa subunit of DNA fragmentation factor 8461-8466 induces DNA fragmentation and chromatin condensation during apoptosis
Xuesong Liu, Peng Li, Piotr Widlak, Hua Zou, Xu Luo, William T. Garrard, and Xiaodong Wang
Conversion of a human low-density lipoprotein 8467-8472 receptor ligand-binding repeat to a virus receptor: Identification of residues important for ligand specificity
Lijun Rong, Kristin Gendron, and Paul Bates
Synergy between simulation and experiment in 8473-8478 describing the energy landscape of protein folding
Andreas G. Ladurner, Laura S. Itzhaki, Valerie Daggett, and Alan R. Fersht
Telomerase reverse transcriptase genes identified in 8479-8484 Tetrahymena thermophila and Oxytricha trifallax
Tracy M. Bryan, Jamie M. Sperger, Karen B. Chapman, and Thomas R. Cech
The reverse transcriptase component of the 8485-8490 Tetrahymena telomerase ribonucleoprotein complex
Kathleen Collins and Leena Gandhi
In vivo and in vitro complementation of the 8491-8495 N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system by the cloned C-terminal domain
Alexey Fomenkov, Airat Valiakhmetov, Ludwig Brand, and Saul Roseman
A C-terminal motif found in the f32-adrenergic 8496-8501 receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins
Randy A. Hall, Lynda S. Ostedgaard, Richard T. Premont, Jeremy T. Blitzer, Nadeem Rahman, Michael J. Welsh, and Robert J. Lefkowitz
The allosteric mechanism of the chaperonin GroEL: 8502-8507 A dynamic analysis
Jianpeng Ma and Martin Karplus
3,N4-ethenocytosine, a highly mutagenic adduct, is a 8508-8513 primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase
Murat Saparbaev and Jacques Laval
Activities of adenovirus virus-associated RNAs: 8514-8519 Purification and characterization of RNA binding proteins
Huey-Jane Liao, Ryuji Kobayashi, and Michael B. Mathews
Human thioredoxin reductase from HeLa cells: 8520-8525 Selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin
Sergey N. Gorlatov and Thressa C. Stadtman
Concerted formation of macromolecular 8526-8531 Suppressor-mutator transposition complexes
Ramesh Raina, Michael Schlappi, Balasulojini Karunanandaa, Adam Elhofy, and Nina Fedoroff
A cloning method for caspase substrates that uses the 8532-8537 yeast two-hybrid system: Cloning of the antiapoptotic gene gelsolin
Shinji Kamada, Hajime Kusano, Hisakazu Fujita, Makoto Ohtsu, Richard Chikara Koya, Noboru Kuzumaki, and Yoshihide Tsujimoto
Mammalian mediator of transcriptional regulation 8538-8543 and its possible role as an end-point of signal transduction pathways
Yi Wei Jiang, Philippe Veschambre, Hediye Erdjument-Bromage, Paul Tempst, Joan W. Conaway, Ronald C. Conaway, and Roger D. Kornberg
The exocyclic groups of DNA modulate the affinity 8544-8549 and positioning of the histone octamer
Memmo Buttinelli, Andrew Minnock, Gianna Panetta, Michael Waring, and Andrew Travers
Mechanism of DNA segregation in prokaryotes: 8550-8555 Replicon pairing by parC of plasmid RI
Rasmus Bugge Jensen, Rudi Lurz, and Kenn Gerdes
In search of a mutational hotspot 8556-8561 Zafer Hatahet, Meixia Zhou, Linda J. Reha-Krantz, Scott W. Morrical, and Susan S. Wallace
Variability in the stability of DNA-peptide nucleic 8562-8567 acid (PNA) single-base mismatched duplexes: Real-time hybridization during affinity electrophoresis in PNA-containing gels
Gabor L. Igloi
Mismatch repair deficiency associated with 8568-8573 overexpression of the MSH3 gene
Giancarlo Marra, Ingram laccarino, Teresa Lettieri, Giuseppe Roscilli, Paola Delmastro, and Josef Jiricny
Control of retinoblastoma protein-independent 8574-8579 hematopoietic cell cycle by the pRB-related p130
Yutaka Hoshikawa, Akio Mori, Keiko Amimoto, Koji Iwabe, and Masanori Hatakeyama
BIOPHYSICS
"Hidden" sequence periodicities and protein architecture 8580-8584 S. Rackovsky
Gating modifier toxins reveal a conserved structural 8585-8589 motif in voltage-gated Ca2+ and K+ channels
Yingying Li-Smerin and Kenton J. Swartz
The proton collecting function of the inner surface of 8590-8595 cytochrome c oxidase from Rhodobacter sphaeroides
Yael Marantz, Esther Nachliel, Anna Aagaard, Peter Brzezinski, and Menachem Gutman
Identification of viral mutants by mass spectrometry 8596-8601 J. Kathleen Lewis, Mohammed Bendahmane, Thomas J. Smith, Roger N. Beachy, and Gary Siuzdak
Kinetics of conformational fluctuations in DNA 8602-8606 hairpin-loops
Grego ire Bo nn et, O leg Krich evsky, and Albert Libchaber
VI
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
ADP ribosylation factor regulates spectrin binding to 8607-8612 the Golgi complex
Anna Godi, Ivana Santone, Paolo Pertile, Prasad Devarajan, Paul R. Stabach, Jon S. Morrow, Giuseppe Di Tullio, Roman Polishchuk, Tamara C. Petrucci, Alberto Luini, and Maria Antonietta De Matteis
Localization of ADP-ribosylation factor domain 8613-8618 protein 1 (ARDI) in lysosomes and Golgi apparatus
Nicolas Vitale, Koji Horiba, Victor J. Ferrans, Joel Moss, and Martha Vaughan
A yeast glutamine tRNA signals nitrogen status for 8619-8624 regulation of dimorphic growth and sporulation
L. E. Murray, N. Rowley, I. W. Dawes, G. C. Johnston, and R. A. Singer
A family of fatty acid transporters conserved from 8625-8629 mycobacterium to man
David Hirsch, Andreas Stahl, and Harvey F. Lodish
Disruption of a PEX1-PEX6 interaction is the most 8630-8635 common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease
Brian V. Geisbrecht, Cynthia S. Collins, Bernadette E. Reuber, and Stephen J. Gould
Localization of myosin-V in the centrosome 8636-8641 Enilza M. Espreafico, Donald E. Coling, Vasiliki Tsakraklides, Karin Krogh, Joseph S. Wolenski, Gilda Kalinec, and Bechara Kachar
Evidence that phospholipase A2 activity is required 8642-8647 for Golgi complex and trans Golgi network membrane tubulation
Paul de Figueiredo, Daniel Drecktrah, John A. Katzenellenbogen, Marian Strang, and William J. Brown
Telomere length regulation in mice is linked to a 8648-8653 novel chromosome locus
Lingxiang Zhu, Karen S. Hathcock, Prakash Hande, Peter M. Lansdorp, Michael F. Seldin, and Richard J. Hodes
DEVELOPMENTAL BIOLOGY
Targeted oncogenesis of hormone-negative pancreatic 8654-8659 islet progenitor cells
Thomas L. Jetton, J. Michael Moates, Jill Lindner, Christopher V. E. Wright, and Mark A. Magnuson
EVOLUTION
Resonating circadian clocks enhance fitness in 8660-8664 cyanobacteria
Yan Ouyang, Carol R. Andersson, Takao Kondo, Susan S. Golden, and Carl Hirschie Johnson
Productivity, individual-level and colony-level 8665-8669 flexibility, and organization of work as consequences of colony size
Istvan Karsai and John W. Wenzel
Antarctic fish hemoglobins: Evidence for adaptive 8670-8675 evolution at subzero temperature
Luca Bargelloni, Stefania Marcato, and Tomaso Patarnello
The evolution of interspecific mutualisms 8676-8680 Michael Doebeli and Nancy Knowlton
Testing migration patterns and estimating founding 9047-9052 population size in Polynesia by using human mtDNA sequences
Rosalind P. Murray-McIntosh, Brian J. Scrimshaw, Peter J. Hatfield, and David Penny
GENETICS
A member of a family of sulfate-activating enzymes 8681-8685 causes murine brachymorphism
Kiyoto Kurima, Matthew L. Warman, Srinivasan Krishnan, Miriam Domowicz, Richard C. Krueger, Jr., Andrea Deyrup, and Nancy B. Schwartz
Knockout of the abetalipoproteinemia gene in mice: 8686-8691 Reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes
Martin Raabe, Laura M. Flynn, Constance H. Zlot, Jinny S. Wong, Murielle M. V6niant, Robert L. Hamilton, and Stephen G. Young
Targeted disruption of Paxl defines its null phenotype 8692-8697 and proves haploinsufficiency
Bettina Wilm, Edgar Dahl, Heiko Peters, Rudi Balling, and Kenji Imai
Biallelic inactivation of hMLHI by epigenetic gene 8698-8702 silencing, a novel mechanism causing human MSI cancers
Martina L. Veigl, Lakshmi Kasturi, Joseph Olechnowicz, AiHong Ma, James D. Lutterbaugh, Sumudra Periyasamy, Guo-Min Li, James Drummond, Paul L. Modrich, W. David Sedwick, and Sanford D. Markowitz
Positional cloning of ZNF217 and NABC1: Genes 8703-8708 amplified at 20q13.2 and overexpressed in breast carcinoma
Colin Collins, Johanna M. Rommens, David Kowbel, Tony Godfrey, Minna Tanner, Soo-in Hwang, Daniel Polikoff, Genevieve Nonet, Joanne Cochran, Ken Myambo, Karen E. Jay, Jeff Froula, Thomas Cloutier, Wen-Lin Kuo, Paul Yaswen, Shanaz Dairkee, Jennifer Giovanola, Gordon B. Hutchinson, Jorma Isola, Olli-P Kallioniemi, Mike Palazzolo, Chris Martin, Cheryl Ericsson, Dan Pinkel, Donna Albertson, Wu-Bo Li, and Joe W. Gray
Chromosomal basis of X chromosome inactivation: 8709-8714 Identification of a multigene domain in Xpll.21-pll.22 that escapes X inactivation
Andrew P. Miller and Huntington F. Willard
Variable and tissue-specific hormone resistance in 8715-8720 heterotrimeric G, protein a-subunit (Gsa) knockout mice is due to tissue-specific imprinting of the G,a gene
Shuhua Yu, Dawen Yu, Eric Lee, Michael Eckhaus, Randy Lee, Zakia Corria, Domenico Accili, Heiner Westphal, and Lee S. Weinstein
The Upf3 protein is a component of the surveillance 8721-8726 complex that monitors both translation and mRNA turnover and affects viral propagation
Maria J. Ruiz-Echevarria, Jason M. Yasenchak, Xia Han, Jonathan D. Dinman, and Stuart W. Peltz
Evidence for gene silencing by endogenous 8727-8732 DNA methylation
Robin Holliday and Thu Ho
vii
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
Tumors of DNA mismatch repair-deficient hosts 8739-8743 exhibit dramatic increases in genomic instability
Agnes Baross-Francis, Susan E. Andrew, Janice E. Penney, and Frank R. Jirik
Nitrilase and Fhit homologs are encoded as fusion 8744-8749 proteins in Drosophila melanogaster and Caenorhabditis elegans
Yuri Pekarsky, Manuela Campiglio, Zurab Siprashvili, Teresa Druck, Yurii Sedkov, Sergei Tillib, Alexandra Draganescu, Peter Wermuth, Joel H. Rothman, Kay Huebner, Arthur M. Buchberg, Alexander Mazo, Charles Brenner, and Carlo M. Croce
Male-specific transcription initiation of the C4-Slp 8750-8755 gene in mouse liver follows activation of STAT5
N. Varin-Blank, E. Dondi, M. Tosi, C. Hernandez, L. Boucontet, H. Gotoh, T. Shiroishi, K. Moriwaki, and T. Meo
Mitogen-activated protein kinases enhance long-range 8756-8760 activation by the ,B-globin locus control region
Wayne K. Versaw, Volker Blank, Nancy M. Andrews, and Emery H. Bresnick
unc-1: A stomatin homologue controls sensitivity to 8761-8766 volatile anesthetics in Caenorhabditis elegans
S. Rajaram, M. M. Sedensky, and P. G. Morgan
c-Fetoprotein gene sequences mediatingAfr2 8767-8772 regulation during liver regeneration
David K. Jin, Jean Vacher, and Miriam H. Feuerman
Signaling pathways in Ras-mediated tumorigenicity 8773-8778 and metastasis
Craig P. Webb, Linda Van Aelst, Michael H. Wigler, and George F. Vande Woude
IMMUNOLOGY
FYB (FYN binding protein) serves as a binding partner 8779-8784 for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells
Junke Liu, Hyun Kang, Monika Raab, Antonio J. da Silva, Stine-Kathrein Kraeft, and Christopher E. Rudd
Activation of preexisting T cell clones by targeted 8785-8790 interleukin 2 therapy
Per Thor Straten, Per Guldberg, Tina Seremet, Ralph A. Reisfeld, Jesper Zeuthen, and Jurgen C. Becker
Both DNA strands of antibody genes are 8791-8794 hypermutation targets
Cesar Milstein, Michael S. Neuberger, and Rodger Staden
MEDICAL SCIENCES
Paracrine expression of a native soluble vascular 8795-8800 endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
Corey K. Goldman, Richard L. Kendall, Gustavo Cabrera, Liliana Soroceanu, Yuji Heike, G. Yancey Gillespie, Gene P. Siegal, Xianzhi Mao, Andrew J. Bett, William R. Huckle, Kenneth A. Thomas, and David T. Curiel
Myocyte proliferation in end-stage cardiac failure 8801-8805 in humans
Jan Kajstura, Annarosa Leri, Nicoletta Finato, Carla Di Loreto, Carlo A. Beltrami, and Piero Anversa
Ligands for peroxisome proliferator-activated 8806-8811 receptory and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
Elena Elstner, Carsten Muller, Kozo Koshizuka, Elizabeth A. Williamson, Dorothy Park, Hiroya Asou, Peter Shintaku, Jonathan W. Said, David Heber, and H. Phillip Koeffler
Prion protein expression in different species: Analysis 8812-8816 with a panel of new mAbs
Gianluigi Zanusso, Dacai Liu, Sergio Ferrari, Ivan Hegyi, Xinghua Yin, Adriano Aguzzi, Simone Hornemann, Susanne Liemann, Rudi Glockshuber, Jean C. Manson, Paul Brown, Robert B. Petersen, Pierluigi Gambetti, and Man-Sun Sy
A second major native von Hippel-Lindau gene 8817-8822 product, initiated from an internal translation start site, functions as a tumor suppressor
Alan Schoenfeld, Eliot J. Davidowitz, and Robert D. Burk
Up-regulation of inducible nitric oxide synthase 8823-8828 expression in cancer-prone p53 knockout mice
Stefan Ambs, Mofolusara 0. Ogunfusika, William G. Merriam, William P. Bennett, Timothy R. Billiar, and Curtis C. Harris
Pengnian Lin, Jake A. Buxton, Ann Acheson, Czeslaw Radziejewski, Peter C. Maisonpierre, George D. Yancopoulos, Keith M. Channon, Laura P. Hale, Mark W. Dewhirst, Samuel E. George, and Kevin G. Peters
hZAC encodes a zinc finger protein with 8835-8840 antiproliferative properties and maps to a chromosomal region frequently lost in cancer
A. Varrault, E. Ciani, F. Apiou, B. Bilanges, A. Hoffmann, C. Pantaloni, J. Bockaert, D. Spengler, and L. Journot
Mast cells mediate acute inflammatory responses to 8841-8846 implanted biomaterials
Liping Tang, Timothy A. Jennings, and John W. Eaton
Somatic mutations of the ,B-catenin gene are frequent 8847-8851 in mouse and human hepatocellular carcinomas
Alix de La Coste, Beatrice Romagnolo, Pierre Billuart, Claire-Ang6lique Renard, Marie-Annick Buendia, Olivier Soubrane, Monique Fabre, Jamel Chelly, Cherif Beldjord, Axel Kahn, and Christine Perret
The Epstein-Barr virus nuclear protein SM is both 8852-8857 a post-transcriptional inhibitor and activator of gene expression
Vivian Ruvolo, Eryu Wang, Sarah Boyle, and Sankar Swaminathan
VI.ii
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
Increased E2F1 activity induces skin tumors in mice 8858-8863 heterozygous and nullizygous for p53
Angela M. Pierce, Irma B. Gimenez-Conti, Robin Schneider-Broussard, Luis A. Martinez, Claudio J. Conti, and David G. Johnson
Growth hormone-releasing hormone antagonist 8864-8868 MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of insulin-like growth factor II in tumors
Najib Lamharzi, Andrew V. Schally, Mikl6s Koppan, and Kate Groot
Early establishment of a pool of latently infected, 8869-8873 resting CD4+ T cells during primary HIV-1 infection
Tae-Wook Chun, Delphine Engel, M. Michelle Berrey, Theresa Shea, Lawrence Corey, and Anthony S. Fauci
Potent inhibition of respiratory syncytial virus 8874-8879 replication using a 2-SA-antisense chimera targeted to signals within the virus genomic RNA
Mark R. Player, Dale L. Barnard, and Paul F. Torrence
Stroke protection by 3-hydroxy-3-methylglutaryl 8880-8885 (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
Matthias Endres, Ulrich Laufs, Zhihong Huang, Tadashi Nakamura, Paul Huang, Michael A. Moskowitz, and James K. Liao
Dual effect of interleukin 4 on HIV-1 expression: 8886-8891 Implications for viral phenotypic switch and disease progression
Antonio Valentin, Wenhong Lu, Margherita Rosati, Ralf Schneider, Jan Albert, Anders Karlsson, and George N. Pavlakis
Russell T. Matthews, Lichuan Yang, Susan Browne, Myong Baik, and M. Flint Beal
Role of peroxisome proliferator-activated receptor a 8898-8903 in disease of pancreatic /3 cells
Yan-Ting Zhou, Michio Shimabukuro, May-Yun Wang, Young Lee, Moritake Higa, Joseph L. Milburn, Christopher B. Newgard, and Roger H. Unger
Leukoregulin induction of protein expression in 8904-8909 human orbital fibroblasts: Evidence for anatomical site-restricted cytokine-target cell interactions
Donald A. Young, Charles H. Evans, and Terry J. Smith
A phage display approach for rapid antibody 8910-8915 humanization: Designed combinatorial V gene libraries
Christoph Rader, David A. Cheresh, and Carlos F. Barbas III
MICROBIOLOGY
A bacterial cytokine 8916-8921 Galina V. Mukamolova, Arseny S. Kaprelyants, Danielle I. Young, Michael Young, and Douglas B. Kell
Pathogenic adaptation of Escherichia coli by natural 8922-8926 variation of the FimH adhesin
Evgeni V. Sokurenko, Veronika Chesnokova, Daniel E. Dykhuizen, Itzhak Ofek, Xue-Ru Wu, Karen A. Krogfelt, Carsten Struve, Mark A. Schembri, and David L. Hasty
Systematic identification of essential genes by in vitro 8927-8932 mariner mutagenesis
Brian J. Akerley, Eric J. Rubin, Andrew Camilli, David J. Lampe, Hugh M. Robertson, and John J. Mekalanos
NEUROBIOLOGY
Characterization and solubilization of bitter-responsive 8933-8938 receptors that couple to gustducin
Ding Ming, Luis Ruiz-Avila, and Robert F. Margolskee
Functional connectivity of the angular gyrus in 8939-8944 normal reading and dyslexia
B. Horwitz, J. M. Rumsey, and B. C. Donohue
Spatiotemporal imaging of human brain activity using 8945-8950 functional MRI constrained magnetoencephalography data: Monte Carlo simulations
Arthur K. Liu, John W. Belliveau, and Anders M. Dale
Social inhibition of song imitation among sibling male 8951-8956 zebra finches
Ofer Tchernichovski and Fernando Nottebohm
The superior colliculus-pretectum mediates the direct 8957-8962 effects of light on sleep
Ann M. Miller, William H. Obermeyer, Mary Behan, and Ruth M. Benca
NaN, a novel voltage-gated Na channel, is expressed 8963-8968 preferentially in peripheral sensory neurons and down-regulated after axotomy
S. D. Dib-Hajj, L. Tyrrell, J. A. Black, and S. G. Waxman
Direct effects of metabotropic glutamate receptor 8969-8974 compounds on native and recombinant N-methyl-D-aspartate receptors
Anis Contractor, Robert W. Gereau, IV, Tim Green, and Stephen F. Heinemann
Geometric and viscous components of the tortuosity 8975-8980 of the extracellular space in the brain
Dmitri A. Rusakov and Dimitri M. Kullmann
Visual representations during saccadic eye movements 8981-8984 Tirin Moore, Andreas S. Tolias, and Peter H. Schiller
PHARMACOLOGY
Ligand-independent activation of platelet-derived 8985-8990 growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells
Andreas Herrlich, Henlrik Daub, Axel Knebel, Peter Herrlich, Axel Ullrich, Gunter Schultz, and Thomas Gudermann
ix
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
Cloning and characterization of a cAMP-specific 8991-8996 cyclic nucleotide phosphodiesterase
S. H. Soderling, S. J. Bayuga, and J. A. Beavo
PHYSIOLOGY
S-Sulfohemoglobin and disulfide exchange: The 8997-9002 mechanisms of sulfide binding by Riftia pachyptila hemoglobins
Franck Zal, Emmanuelle Leize, Francois H. Lallier, Andr6 Toulmond, Alain Van Dorsselaer, and James J. Childress
Endogenous or overexpressed cGMP-dependent 9003-9008 protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells
Stepan Gambaryan, Charlotte Wagner, Albert Smolenski, Ulrich Walter, Wolfgang Poller, Winfried Haase, Armin Kurtz, and Suzanne M. Lohmann
PLANT BIOLOGY
Ferredoxin-1 mRNA is destabilized by changes in 9009-9013 photosynthetic electron transport
Marie E. Petracek, Lynn F. Dickey, Tuyen T. Nguyen, Christiane Gatz, Dolores A. Sowinski, George C. Allen, and William F. Thompson
Successful search for a resistance gene in tomato 9014-9018 targeted against a virulence factor of a fungal pathogen
Richard Laug6, Matthieu H. A. J. Joosten, Jair P. W. Haanstra, Paul H. Goodwin, Pim Lindhout, and Pierre J. G. M. De Wit
Cloning of the Arabidopsis ent-kaurene oxidase 9019-9024 gene GA3
Chris A. Helliwell, Candice C. Sheldon, Mark R. Olive, Amanda R. Walker, Jan A. D. Zeevaart, W. James Peacock, and Elizabeth S. Dennis
His-65 in the proton-sucrose symporter is an essential 9025-9030 amino acid whose modification with site-directed mutagenesis increases transport activity
Jade M.-Y. Lu and Daniel R. Bush
POPULATION BIOLOGY
Chytridiomycosis causes amphibian mortality 9031-9036 associated with population declines in the rain forests of Australia and Central America
Lee Berger, Rick Speare, Peter Daszak, D. Earl Green, Andrew A. Cunningham, C. Louise Goggin, Ron Slocombe, Mark A. Ragan, Alex D. Hyatt, Keith R. McDonald, Harry B. Hines, Karen R. Lips, Gerry Marantelli, and Helen Parkes
Mortality invariants and their genetic implications 9037-9041 Mark Yacov Azbel'
PSYCHOLOGY
Interhemispheric disconnection syndrome in 9042-9046 Alzheimer's disease
Testing migration patterns and estimating founding 9047-9052 population size in Polynesia by using human mtDNA sequences
Rosalind P. Murray-McIntosh, Brian J. Scrimshaw, Peter J. Hatfield, and David Penny
Clines of nuclear DNA markers suggest a largely 9053-9058 Neolithic ancestry of the European gene pool
Lounes Chikhi, Giovanni Destro-Bisol, Giorgio Bertorelle, Vincenzo Pascali, and Guido Barbujani
CORRECTIONS
BIOCHEMISTRY The chromatin unfolding domain of chromosomal 9059 protein HMG-14 targets the N-terminal tail of histone H3 in nucleosomes
Lothar Trieschmann, Brian Martin, and Michael Bustin
GENETICS Evolution of rhizobia by acquisition of a 500-kb 9059 symbiosis island that integrates into a phe-tRNA gene
John T. Sullivan and Clive W. Ronson
PLANT BIOLOGY Association of the Arabidopsis CTR1 Raf-like kinase 9060 with the ETRI and ERS ethylene receptors
Karen L. Clark, Paul B. Larsen, Xiaoxia Wang, and Caren Chang
AUTHOR INDEX xi-xiii
INFORMATION FOR AUTHORS xiv-xvi
SIZING WORKSHEET xvii
DOCUMENTATION REPORT xviii
COPYRIGHT ASSIGNMENT FORM xix
SUBSCRIPTION FORM xx
CLASSIFIED ADVERTISEMENTS xxi-xxiii
Cover photograph: Hildreth Meiere's emblematic figure depicting Mathematics: One of eight radial panels on the dome of the Great Hall at the National Academy of Sciences.
x
This content downloaded from 169.229.32.136 on Wed, 7 May 2014 14:36:42 PMAll use subject to JSTOR Terms and Conditions
