Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 76, No. 4 (Apr., 1979), pp. v-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/69541 .

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APRIL 1979

VOLUME 76

NUMBER 4

OFOF T

()F THE UNITED STATES ()F AIWERA >

OF THE UNITED STATES OF AMERICA

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Proceedings OF THE

National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers of the Academy

PHILIP HANDLER President SAUNDECRS MAC LANE Vice President DAVID R. GODDARD Home Secretary THOMAS F. MALONE Foreign Secretary E. R. PIORE Treasurer

Editorial Board of/the Proceedings

ROBERT L. SINSHEIMER Chairman HARRISON SHULL Vice Chairman DAVID R. GODDARD Home Secretary THOMAS F. MALONE Foreign Secretary E. R. PIORE Treasurer

K. FRANK AUSTEN JOHN R. BORCHERT P. D. BoYER JULIUS H. COMROE, JR. JOHN E. DOWLING HARRY EAGLE RICHARD M. HELD HENRY S. KAPLAN

DANIEL E. KOSHLAND, JR. S. M. LilSET NEVIN S. SCRIMSHAW E. R. STADTMAN EIJIAS M. STEIN HOWARD M. TEMIN JAMES TOBIN CHARLES H. TOWNES

JAMES B. WYNGAARDEN

Managing Editor: BERNARD K. FORSCHER Associate Editor: GARY T. COCKS Associate Editor: MURRIE W. BURGAN Associate Editor: SHEILA L. ROSENTHALI Assistant Managing Editor: STEPHANIE G. PASSMAN

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? 1979 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.

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AUTHOR INDEX, APRIL 1979

Aaronson, S. A. 1677 Adelstein, R. S. 1653 Adhya, S. 1613 Agarwal, K. L. 1770 Aidells, B. D. 1863 Aller, L. H. 1525 Alving, C. R. 1673 Antoniades, H. N. 1809 Aoki, N. 2013 Armond, P. A. 1901 Artz, S. W. 1726 Arvan, P. 1873 Arzone, A. 1916 Baliga, B. S. 1751 Bare, A. L. 1793 Bare, R. M. 1793 Bazin, H. 2008 Benoff, S. 1853 Berg, D. K. 2072 Bishop, J. M. 1804 Blanckaert, N. 2037 Blobel, G. 1795 Bloom, F. E. 2077 Blout, E. R. 1775 Bologna, M. 1848 Borek, C. 1800 Borst, P. 1663 Bos, J. L. 1663 Bouloy, M. 1618 Bourguignon, J.-P. 1550 Bracha, M. 1687 Brady, R. 0. 1673 Breindl, M. 1938 Brink, L. 1756 Bronner, M. E. 1843 Brot, N. 1716 Brown, J. A. 1957 Brown, J. H. 1570 Brown, W. M. 1967 Brunton, L. L. 1570 Bryan, V. M. 1962 Bryant, P. J. 1929 Burakoff, S. 1982 Butt, T. R. 1628 Butterworth, A. E. 1982 Cagan, R. H. 1692 Caldwell, P. 1716 Canaani, E. 1677 Carson, H. L. 1929 Cerf, R. 1780 Chan-Palay, V. 2067 Chapman, D. 1542 Chatterjee, B. 1833 Choppin, P. W. 2047 Christopher, C. W. 1878 Cohen, A. M. 1843 Cohen, S. M. 1603 Cranefield, P. F. 1783 Crockett, C. P. 1711 Cunningham, R. P. 1638 Czyzak, S. J. 1525 Daniel, M. D. 2042 DasGupta, C. 1638 Dausman, J. 1938 Davidson, J. N. 1731 Davis, J. N. 2057 de Haro, C. 1741 De Leo, G. 1916 DeLorenzo, R. J. 1838 DeLuca, C. 1957 Dennis, P. P. 1697 Dixon, G. H. 1682 Djurickovic, D. 1793 Doehmer, J. 1938 Dosch, H.-M. 1998 Duesberg, P. H. 1633 Dulbecco, R. 1848

Dunham, P. 1873 Dutchak, D. 1833 Eanes, W. F. 1924 Evans, H. J. 1788 Falkow, S. 1873 Fibach, E. 1906 Figurski, D. H. 1648 Fink, A. L. 1566 Finkelstein, R. A. 2052 Fish, D. C. 1793 Fisher, M. M. 2008 Fishman, P. H. 1673 Fitzpatrick, F. A. 1765 Flaherty, L. 1990 Freedman, S. D. 1838 Friend, C. 2018 Fritz, L. C. 2062 Gadsby, D. C. 1783 Gallo, R. C. 2032 Gambari, R. 1906 Garcia-Blanco, M. A.

1643 Gardner, J. F. 1706 Gefter, M. L. 1658 Gelfand, E. W. 1998 George, M., Jr. 1967 Gerber, L. D. 1756 Glaser, D. A. 1863 Glassberg, J. 1702 Goldberg, G. 1716 Goldsmith, G. H. 2013 Gollan, J. 2037 Good, R. A. 1972 Gorio, A. 2062 Gottesman, M. 1623 Gottesman, S. 1623 Grivell, L. A. 1663 Guillemin, R. 2077 Gupta, S. 1972 Gutmann, N. S. 1896 Hall, W. W. 2047 Hanus, F. J. 1788 Harris, H. 1948 Hathaway, D. R. 1653 Hayes, J. S. 1570 Helinski, D. R. 1648 Heller, R. A. 1721 Helms, C. 1952 Hensgens, L. A. M. 1663 Henson, P. M. 1986 Herzenberg, L. A. 1962 Hirth, L. 1780 Hoffstein, S. 1873 Honda, T. 2052 Hopkins, J. 1833 Hruby, D. E. 1887 Hsie, A. W. 1819 Huebner, R. J. 1793 Innerarity, T. L. 1746 Isselbacher, K. J. 1878 Jackson, R. C. 1795 Jacob, F. 1891 Jaenisch, R. 1938 Jakob, H. 1891 John, F. 1559 Johnson, M. S. 1924 Jones, P. A. 1882 Jump, D. B. 1628 Kalckar, H. M. 1878 Karle, I. L. 1532 Karlsson, F. A. 2022 Kates, J. R. 1887 Keyes, C. D. 1525 Kimura, S. 1756 Kingston, B. L. 1668 Kingston, I. B. 1668 Kirpekar, S. M. 2081

Klein, D. J. 1529 Klein, G. 2042 Klotzbucher, R. 1721 Knight, E., Jr. 1824 Komor, E. 1814 Konrad, M. W. 1863 Korant, B. D. 1824 Kornberg, A. 1702 Kream, R. M. 1593 Kreutzer, D. L. 1986 Kriss, J. P. 2003 Krug, R. M. 1618 Kwong, S. 1598 Lacour, F. 2018 Lamb, R. A. 2047 Lau, A. S. 1751 Lawson, H. B. 1550 Lee, J. J. 1998 Lee, L. W. Y. 1561 Levinson, A. D. 1804 Levintow, L. 1804 Levy-Wilson, B. 1682 Lewis, H. 1697 Lewis, R. V. 1756 Lietze, A. 1828 Lingappa, V. R. 1795 Little, J. B. 1943 London, I. M. 1575 Luka, J. 2042 Lynn, D. L. 1887 McConnell, H. M. 1537 Maeda, T. 1537 Mahley, R. W. 1746 Maier, R. J. 1788 Maitra, U. 1613 Maniatis, G. 1906 Marcus, M. M. 1795 Marcus, S. L. 1736 Margolis, R. K. 1711 Margolis, R. U. 1711 Marks, P. A. 1906 Maurer, S. C. 1838 Mayer, S. E. 1570 Meehan, P. 1566 Mehdi, S. Q. 2003 Metcalf, E. R. 1561 Metcalf, R. L. 1561 Mevarech, M. 1770 Meyer, R. R. 1702 Michels, B. 1780 Mikulski, A. 1828 Miller, R. 1800 Mitchell, W. C. 1561 Moak, G. 1948 Moroi, M. 2013 Morris, R. W. 1692 Moss, J. 1673 Mount, C. D. 2027 Munro, H. N. 1751 Mutolo, V. 1916 Nadal-Ginard, B. 1853 Nagasawa, H. 1943 Nagy, B. 2008 Nahon-Merlin, E. 2018 Nakayama, E. 1977 Nicholson, W. E. 2027 Nishino, H. 1878 Nomura, M. 1697 Novick, P. 1858 Noyes, B. E. 1770 Ochoa, S. 1741 Odagiri, E. 2027 Oettgen, H. F. 1977 Ogawa, 5. 1603 Ohno, 5. 2042 Oi, V. T. 1962 Old, L. J. 1977

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AUTHOR INDEX, APRIL 1979

Oppermann, H. 1804 Orr, W. 1986 Orth, D. N. 2027 Ottenheym, H. C. J.

1532 Pabo, C. 0. 1608 Pain, C. 1800 Palay, S. L. 2067 Parker, M. G. 1580 Parks, D. R. 1962 Parsons, S. M. 1589 Patterson, D. 1731 Paulin, D. 1891 Peattie, D. A. 1760 Perreau, J. 1891 Petryshyn, R. 1575 Pfeiffer, P. 1780 Phan, S. H. 1986 Phong, D. H. 1554 Pink, D. A. 1542 Piszkiewicz, D. 1589 Platsoucas, C. D. 1972 Plotch, S. J. 1618 Polis, B. D. 1598 Polis, E. 1598 Post, L. E. 1697 Prat, J. C. 2081 Primakoff, P. 1726 Ptashne, M. 1608 Putnam, F. W. 1668 Radding, C. M. 1638 Rae, P. A. 1896 Rand-Meir, T. 1589 Rapaport, E. 1643 Ravdin, P. M. 2072 Reese, J. B. 1570 Reitz, M. S., Jr. 2032 Reuben, R. C. 1906 Revoltella, R. 2018 Richards, R. L. 1673 Rifkind, R. A. 1906 Rinaldi, A. M. 1916 Robbins, A. R. 1911 Rogers, J. 2077 Rossier, J. 2077 Roy, A. K. 1833 Roy, R. K. 1751 Rubinstein, M. 1756 Rulon, K. 1994 Saito, H. 2013

Salcher, I. 1916 Sarkar, N. H. 1736 Sarkar, P. 1613 Sarkar, S. 1751 Sassa, S. 1906 Sauer, R. T. 1608 Schekman, R. 1858 Scher, C. D. 1809 Schermer, D. 1532 Schiller, R. M. 1878 Schimmer, B. P. 1896 Schlesinger, M. J. 1687 Schmid, R. 2037 Schmidt, M. F. G. 1687 Schulz, J.-A. 1780 Scrace, G. T. 1580 Sen, G. C. 1736 Shapiro, J. A. 1933 Shaw, P. A. 1906 Sher, A. 1982 Sherman, F. 1952 Sherrell, B. J. 2027 Shibasaki, T. 2077 Shibata, T. 1638 Shiku, H. 1977 Shininger, T. L. 1921 Shows, T. B. 1957 Shulman, R. G. 1603 Simon, L. D. 1623 Simons, J. 1550 Simpson, L. 1585 Singh, A. 1952 Slatkin, M. 2084 Smilowitz, H. 1868 Smith, G. T. 1793 Smith, S. W. 1736 Smulson, M. E. 1628 Staehelin, L. A. 1901 Stein, R. 1770 Stein, S. 1756 Stiles, C. D. 1809 Stockert, E. 1977 Stoffel, W. 1721 Storace, A. 1916 Stringfellow, D. A. 1765 Strycharz, G. D. 1697 Sturtevant, J. M. 1608 Sun, C. R. Y. 1819 Sun, N. C. 1819 Talmage, D. W. 1994

Tanner, W. 1814 Tanzer, M. L. 1868 Tennant, R. W. 1819 Thomas, M. D. 1711 Tilley, B. E. 1589 Tomczak, K. 1623 Trachsel, H. 1575 Trimmer, R. W. 1793 Troll, W. 1800 Tsao, J. 1896 Turner, J. R. G. 1924 Uchida, N. 1868 Udenfriend, S. 1756 Underdown, B. J. 2008 Unger, M. 1848 Urist, M. R. 1828 Vadas, M. A. 1982 Valenzuela, D. 1613 Varani, J. 1986 Varmus, H. E. 1804 Vogt, P. K. 1633 Waggoner, P. E. 1547 Wagner, H. R. 2057 Walinder, 0. 2022 Wall, F. T. 1529 Wallace, B. A. 1775 Walter, P. 1795 Wang, C. C. 2062 Ward, P. A. 1986 Weber, H. 1814 Webster, R. 0. 1986 Weisgraber, K. H. 1746 Weissbach, H. 1716 Weissmann, G. 1873 Westermark, B. 2022 Wieland, T. 1532 Willecke, K. 1938 Wilson, A. C. 1967 Wilson, D. S. 2084 Windmueller, H. G.

1746 Witz, J. 1780 Wong-Staal, F. 2032 Wu, J.-Y. 2067 Yaniv, M. 1891 Yarranton, G. T. 1658 Yohe, W. B. 1838 Zamecnik, P. C. 1643 Zimmerman, D. 1990 Zukin, R. S. 1593

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Contents (Continued from page ix)

MICROBIOLOGY

Selection of characteristics of a Vibrio cholerae mutant lacking the A (ADP- Takeshi Honda and Richard A. 2052-2056 ribosylating) portion of the cholera enterotoxin (cholera vaccine candidatel Finkelstein diarrhea/intestinal immunity/halo technique/choleragen)

NEUROBIOLOGY

#3-Adrenergic receptor regulation by agonists and membrane depolarization in H. Ryan Wagner and James N. Davis 2057-2061 rat brain slices (desensitization/cyclic AMP accumulation/hormone receptor/cell depolarization/receptor resensitization)

Avermectin Bla irreversibly blocks postsynaptic potentials at the lobster Lawrence C. Fritz, Ching C. Wang, 2062-2066 neuromuscular junction by reducing muscle membrane resistance (chloride and Alfredo Gorio channels/,y-aminobutyric acid/anthelmintic)

Immunocytochemical localization of y-aminobutyric acid transaminase at V. Chan-Palay, J.-Y. Wu, and S. L. 2067-2071 cellular and ultrastructural levels (cerebellum/synapses/harmalinel Palay muscimol)

Inhibition of neuronal acetylcholine sensitivity by a-toxins from Bungarus Peter M. Ravdin and Darwin K. Berg 2072-2076 multicinctus venom (ciliary ganglion neurons/acetylcholine receptors! rhodamine-labeled a-bungarotoxin/cell culture)

Opioid peptides and a-melanocyte-stimulating hormone in genetically obese Jean Rossier, Joseph Rogers, Tamotsu 2077-2080 (ob/ob) mice during development (/3-endorphinlLeu5-enkephalin) Shibasaki, Roger Guillemin, and

Floyd E. Bloom

PHYSIOLOGICAL SCIENCES

Release of catecholamines from perfused cat adrenal gland by veratridine S. M. Kirpekar and J. C. Prat 2081-2083 (acetylcholine/tetrodotoxin/secretion regulation)

POPULATION BIOLOGY

Coevolution in structured demes (population genetics/group selection! M. Slatkin and D. S. Wilson 2084-2087 subdivided populations/mathematical models)

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Contents (Continued from page x)

Antigen-specific identification and cloning of hybridomas with a fluorescence- David R. Parks, Virginia M. Bryan, 1962-1966 activated cell sorter (fluorescent microspheres/monoclonal antibodies! Vernon T. Oi, and Leonard A. immunoglobulin allotypes/autofluorescence) Herzenberg

Rapid evolution of animal mitochondrial DNA (primates/restriction Wesley M. Brown, Matthew George, 1967-1971 endonuclease cleavage maps/gel electrophoresisiDNA melting) Jr., and Allan C. Wilson

IMMUNOLOGY

Separation of human T lymphocyte subpopulations (T,u, Ty) by density Chris D. Platsoucas, Robert A. Good, 1972-1976 gradient electrophoresis (T cell subsets/cell surface charge/Fc receptors! and Sudhir Gupta mitogen response)

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera Eiichi Nakayama, Hiroshi Shiku, 1977-1981 (T lymphocyte/killer cell/differentiation antigensIT cell receptor) Elisabeth Stockert, Herbert F.

Oettgen, and Lloyd J. Old Major histocompatibility complex products restrict the adherence of cytolytic M. A. Vadas, A. E. Butterworth, S. 1982-1985

T lymphocytes to minor histocompatibility antigens or to trinitrophenyl Burakoff, and A. Sher determinants on schistosomula of Schistosoma mansoni (H-2 restriction/ antigen binding)

Chemotactic factor for tumor cells derived from the C5a fragment of W. Orr, S. H. Phan, J. Varani, P. A. 1986-1989 complement component C5 (chemotaxis/leukocytes) Ward, D. L. Kreutzer, R. 0.

Webster, and P. M. Henson

Surface mapping of mouse thymocytes (blocking assay/H-2, TL, and Ly Lorraine Flaherty and Debra 1990-1993 alloantigens/supramolecular repatterning/paraformaldehyde fixation) Zimmerman

Enhancement of the primary cytotoxic response to membrane by a lymphokine Kathleen Rulon and David W. 1994-1997 costimulator (in vitro culture/lymphocyte activation/spleen cells/adherent Talmage cells)

Selective toxicity of purine deoxynucleosides for human lymphocyte growth and Erwin W. Gelfand, Jacob J. Lee, and 1998-2002 function (immune deficiency/cell growth/antibody response) Hans-Michael Dosch

MEDICAL SCIENCES

Cell-mediated lysis of lipid vesicles containing eye muscle protein: Implications Joseph P. Kriss and S. Qasim Mehdi 2003-2007 regarding pathogenesis of Graves ophthalmopathy (T and K lymphocytes/ thyroglobulin/antithyroglobulin/cell membranes/autoimmunity)

Biliary transport of IgA: Role of secretory component (secretory IgA/protein Murray M. Fisher, Barbara Nagy, 2008-2012 transport/hepatocyte) Herve Bazin, and Brian J.

Underdown

Inhibitory spectrum of a2-plasmin inhibitor (plasma inhibitors/Hageman Hidehiko Saito, George H. Goldsmith, 2013-2017 factor/Factor XI/plasma kallikrein/thrombin) Masaaki Moroi, and Nobuo Aoki

Protective effect of immunization with nonviral antigens against Friend Evelyne Nahon-Merlin, Fanny 2018-2021 leukemia virus in mice [poly(A).poly(U)-methylated bovine serum Lacour, Charlotte Friend, and albumin/bovine serum albumin/dinitrophenylated keyhole limpet Roberto Revoltella hemocyanin/gp7l antibody]

Thyrotropin is not a growth factor for human thyroid cells in culture (pituitary Bengt Westermark, F. Anders 2022-2026 trophic hormones/goiter/cell differentiation) Karlsson, and Olov WAlinder

Human placental immunoreactive corticotropin, lipotropin, and ,-endorphin: Emi Odagiri, Barbara J. Sherrell, 2027-2031 Evidence for a common precursor (radioimmunoassay/gel exclusion Charles D. Mount, Wendell E. chromatography/gel electrophoresis/immune affinity chromatography) Nicholson, and David N. Orth

Retrovirus sequences in a leukemic gibbon and its contact: Evidence for partial Flossie Wong-Staal, Marvin S. Reitz, 2032-2036 provirus in the nonleukemic gibbon (type C viruses/molecular Jr., and Robert C. Gallo hybridization/restriction enzymes)

Bilirubin diglucuronide synthesis by a UDP-glucuronic acid-dependent enzyme Norbert Blanckaert, John Gollan, and 2037-2041 system in rat liver microsomes (hepatic metabolism/conjugation/bile Rudi Schmid pigments/glycosides/UDP glucuronosyltransferase)

Detection of a nulcear antigen in Herpesvirus ateles-carrying marmoset lines Shinsuke Ohno, Janos Luka, George 2042-2046 by the acid-fixed nuclear binding technique (tumor antigen/DNA binding! Klein, and Muthiah D. Daniel anticomplement immunofluorescence)

Measles and subacute sclerosing panencephalitis virus proteins: Lack of William W. Hall, Robert A. Lamb, 2047-2051 antibodies to the M protein in patients with subacute sclerosing and Purnell W. Choppin panencephalitis (paramyxoviruses/persistent infection/viral pathogenesis/ membrane proteins/protein synthesis)

(Continued on page viii)

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Contents (Continued from page xi)

Catabolic control of the enhanced alanine-preferring system for amino acid C. William Christopher, Hoyoku 1878-1881 transport in glucose-starved hamster cells requires protein synthesis (a- Nishino, Robert M. Schiller, Kurt aminoisobutyric acid/glucose shiftdown/membrane vesicles/cycloheximide) J. Isselbacher, and Herman M.

Kalckar

Construction of an artificial blood vessel wall from cultured endothelial and Peter A. Jones 1882-1886 smooth muscle cells (mixed cultures/basal lamina/growth kinetics)

Vaccinia virus replication requires active participation of the host cell Dennis E. Hruby, Debra L. Lynn, and 1887-1890 transcriptional apparatus (UV irradiationla-amanitin/virus assembly) Joseph R. Kates

Tropomyosin synthesis accompanies formation of actin filaments in embryonal D. Paulin, J. Perreau, H. Jakob, F. 1891-1895 carcinoma cells induced to differentiate by hexamethylene bisacetamide Jacob, and M. Yaniv (cytoskeleton/immunofluorescence/in vitro differentiation/mouse teratocarcinoma/tropomyosin antibody)

Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)- P. A. Rae, N. S. Gutmann, J. Tsao, 1896-1900 sensitive adenylate cyclase affect adrenal steroidogenesis (hormone action/ and B. P. Schimmer Yl tumor cells/growth control/cell culture)

Lateral and vertical displacement of integral membrane proteins during lipid Paul A. Armond and L. Andrew 1901-1905 phase transition in Anacystis nidulans (plasma membrane/thylakoid Staehelin membrane/reversible particle migration/freeze-fracture)

Tumor promoter-mediated inhibition of cell differentiation: Suppression of the Eitan Fibach, Roberto Gambari, 1906-1910 expression of erythroid functions in murine erythroleukemia cells (Friend Phyllis A. Shaw, George Maniatis, virus/globin mRNA/spectrin/heme/hexamethylene bisacetamide) Roberta C. Reuben, Shigeru Sassa,

Richard A. Rifkind, and Paul A. Marks

Isolation of lysosomal a-mannosidase mutants of Chinese hamster ovary cells April R. Robbins 1911-1915 (replica plating/fluorogenic substrates/enzyme uptake/cell density- dependent enzyme)

DEVELOPMENTAL BIOLOGY

Biochemical and electron microscopic evidence that cell nucleus negatively A. M. Rinaldi, G. De Leo, A. Arzone, 1916-1920 controls mitochondrial genomic activity in early sea urchin development I. Salcher, A. Storace, and V. ([3H]thymidine incorporation/DNA replication) Mutolo

Xylem and nonxylem cell formation in cytokinin-stimulated root tissue: Terry L. Shininger 1921-1923 Quantitative analysis of temperature effects (low temperature/ differentiation/Pisum sativum)

EVOLUTION

Contrasted modes of evolution in the same genome: Allozymes and adaptive John R. G. Turner, Michael S. 1924-1928 change in Heliconius (Lepidoptera/mimicry/heterozygosity/control genes/ Johnson, and Walter F. Eanes neutral evolution)

Change in a secondary sexual character as evidence of incipient speciation in Hampton L. Carson and Peter J. 1929-1932 Drosophila silvestris (evolution/behavior/morphology/sexual selection/ Bryant Hawaii)

GENETICS

Molecular model for the transposition and replication of bacteriophage Mu and James A. Shapiro 1933-1937 other transposable elements (DNA insertion elements/nonhomologous recombination/site-specific recombination/replicon fusion/topoisomerases)

Germ line integration of Moloney leukemia virus: Identification of the Michael Breindl, Johannes Doehmer, 1938-1942 chromosomal integration site (genetic transmission/structural gene/ Klaus Willecke, Jessica Dausman, segregation analysis/somatic cell hybrids/backcross animals) and Rudolf Jaenisch

Effect of tumor promoters, protease inhibitors, and repair processes on x-ray- Hatsumi Nagasawa and John B. Little 1943-1947 induced sister chromatid exchanges in mouse cells (12-0-tetradecanoyl- phorbol 13-acetate/malignant transformation/DNA repair/recombination/ carcinogenesis)

Lack of homology between dog and human placental alkaline phosphatases Gary Moak and Harry Harris 1948-1951 (inhibition/thermostability/electrophoresis/evolution/duplication)

Mutation of the non-Mendelian suppressor, ,6+, in yeast by hypertonic media Arjun Singh, Cynthia Helms, and 1952-1956 (nonsense suppression/Saccharomyces cerevisiae/cytoplasmic inheritance) Fred Sherman

Lysosomal arylsulfatase deficiencies in humans: Chromosome assignments for Chester DeLuca, Judith A. Brown, 1957-1961 arylsulfatase A and B (somatic cell hybrids/human chromosomes 5 and 22/ and Thomas B. Shows metachromatic leukodystrophy/Maroteaux-Lamy syndrome/multiple sulfatase deficiency)

(Continued ofl page ix )

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Contents (Continued from page xii)

Direct measurement of changes in sodium pump current in canine cardiac David C. Gadsby and Paul F. 1783-1787 Purkinje fibers (electrogenic sodium extrusion/voltage clamp! Cranefield acetylstrophanthid in)

BOTANY

Autotrophic growth of H2-uptake-positive strains of Rhizobium japonicum in F. Joe Hanus, Robert J. Maier, and 1788-1792 an atmosphere supplied with hydrogen gas (hydrogenase/legumel Harold J. Evans chemolithotroph/soybean)

CELL BIOLOGY

Induction of rat sarcomas in rats treated with antithymocyte sera after Robert J. Huebner, Donald C. Fish, 1793-1794 transplantation of human cancer cells (antithymocyte sera Draginja Djurickovic, Roy W. immunosuppression/induced rat cancer cells) Trimmer, Alton L. Bare, Robert M.

Bare, and George T. Smith

Tryptic dissection and reconstitution of translocation activity for nascent Peter Walter, Robert C. Jackson, 1795-1799 presecretory proteins across microsomal membranes (prolactin mRNA/ Madeleine M. Marcus, Vishwanath translation in reticulocyte lysate/signal and ribosome receptor domain/ R. Lingappa, and Gunther Blobel transport domain/signal peptidase)

Conditions for inhibiting and enhancing effects of the protease inhibitor Carmia Borek, Richard Miller, 1800-1803 antipain on x-ray-induced neoplastic transformation in hamster and mouse Cynthia Pain, and Walter Troll cells (proteases/DNA repair/x-ray damage/expression of carcinogenesis/ fixation of transformation)

Uninfected vertebrate cells contain a protein that is closely related to the Hermann Oppermann, Arthur D. 1804-1808 product of the avian sarcoma virus transforming gene (src) (protein kinase/ Levinson, Harold E. Varmus, Leon phosphoprotein/immunoprecipitation/peptide maps/phylogenetic Levintow, and J. Michael Bishop conservation)

Purification of human platelet-derived growth factor (platelets/polypeptide Harry N. Antoniades, Charles D. 1809-1813 hormones/fibroblast growth factor) Scher, and Charles D. Stiles

Greatly decreased susceptibility of nonmetabolizing cells towards detergents Ewald Komor, Heinrich Weber, and 1814-1818 (Escherichia coli/Saccharomyces cerevisiae/Chlorella vulgaris/nystatin) Widmar Tanner

Selective growth of some rodent epithelial cells in a medium containing N. C. Sun, C. R. Y. Sun, R. W. 1819-1823 citrulline (fibroblast outgrowth/urea cycle/cancer cell biology) Tennant, and A. W. Hsie

Fibroblast interferon induces synthesis of four proteins in human fibroblast Ernest Knight, Jr., and Bruce D. 1824-1827 cells (interferon action/protein synthesis/two-dimensional electrophoresis) Korant

Solubilized and insolubilized bone morphogenetic protein (cell differentiation/ Marshall R. Urist, Andrzej Mikulski, 1828-1832 osteogenesis/noncollagenous protein) and Arthur Lietze

Superinduction of a2u globulin by actinomycin D: Evidence for drug-mediated Bandana Chatterjee, James Hopkins, 1833-1837 increase in a2u mRNA (androgenic induction/post-transcriptional Denise Dutchak, and Arun K. Roy repression/cell-free translation/hormone action/urinary protein)

Stimulation of Ca2+-dependent neurotransmitter release and presynaptic nerve Robert J. DeLorenzo, Steven D. 1838-1842 terminal protein phosphorylation by calmodulin and a calmodulin-like Freedman, Wendy B. Yohe, and protein isolated from synaptic vesicles (Ca2+-dependent regulator protein/ Steven C. Maurer norepinephrine release/synaptic transmission/synaptosome)

Migratory patterns of cloned neural crest melanocytes injected into host chicken Marianne E. Bronner and Alan M. 1843-1847 embryos (migration/pigment cells/injection technique/differentiation) Cohen

Role of Thy-I antigen in the in vitro differentiation of a rat mammary cell line Renato Dulbecco, Mauro Bologna, 1848-1852 (monoclonal antibodies/domes/immunofluorescence) and Michael Unger

Most myosin heavy chain mRNA in L6E9 rat myotubes has a short poly(A) tail Susan Benoff and Bernardo 1853-1857 (myoblast cell lines/translation in vitro/cDNA hybridization) Nadal-Ginard

Secretion and cell-surface growth are blocked in a temperature-sensitive mutant Peter Novick and Randy Schekman 1858-1862 of Saccharomyces cerevisiae (secretory mutants/vesicles/membrane assembly)

Growth and morphology of colonies of Chinese hamster ovary cells growing on Bruce D. Aidells, Michael W. Konrad, 1863-1867 agar is affected by insulin (quantitative assay for hormones/automated cell and Donald A. Glaser biology)

Monovalent inophores inhibit secretion of procollagen and fibronectin from N. Uchida, H. Smilowitz, and M. L. 1868-1872 cultured human fibroblasts (cations/intracellular vesicles/protein Tanzer glycosylation/collagen synthesis)

Inhibitors of membrane transport reduce lysosomal enzyme secretion from Philip Dunham, Peter Aryan, Stephen 1873-1877 dogfish phagocytes and their killing of sea urchin eggs (cytotoxicity/ Falkow, Sylvia Hoffstein, and d egranulation/ethacrynic acid /f urosemid e/phloretin) Gerald Weissmann

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Contents (Continued from inside back cover)

Nucleotide sequence of the ribosomal protein gene cluster adjacent to the gene Leonard E. Post, Geneva D. 1697-1701 for RNA polymerase subunit ,B in Escherichia coli (protein sequence! Strycharz, Masayasu Nomura, H. transcription initiation/transcription termination/codon usage! Lewis, and Patrick P. Dennis isoaccepting tRNAs)

An Escherichia coli mutant defective in single-strand binding protein is Ralph R. Meyer, Jeffrey Glassberg, 1702-1705 defective in DNA replication (DNA binding protein/helix-destabilizing and Arthur Kornberg protein/phage G4/conditional replication mutant)

Regulation of the threonine operon: Tandem threonine and isoleucine codons Jeffrey F. Gardner 1706-1710 in the control region and translational control of transcription termination (DNA sequencing/attenuationiRNA secondary structure)

Presence of chondroitin sulfate in the neuronal cytoplasm (proteoglycansi R. K. Margolis, M. D. Thomas, C. P. 1711-1715 heparan sulfate/hyaluronic acid/glycoproteins) Crockett, and R. U. Margolis

In vitro regulation of DNA-dependent synthesis of Escherichia coli ribosomal Gregory Goldberg, Paul Caldwell, 1716-1720 protein L12 (transducing phage/gene cloningiRNA polymerase) Herbert Weissbach, and Nathan

Brot

Interactions of a photosensitive analog of cholesterol with Renu A. Heller, Rainer Klotzbiucher, 1721-1725 hydroxymethylglutaryl-CoA reductase (NADPH) and acyl-CoA:cholesterol and Wilhelm Stoffel acyltransferase (lipid-protein interaction/membrane-bound enzymes/ photosensitive probes/25-azidonorcholesterol)

Positive control of lac operon expression in vitro by guanosine 5'-diphosphate Paul Primakoff and Stanley W. Artz 1726-1730 3'-diphosphate (coupled protein synthesis in vitro/transcription initiation/ supercontrol systems/overlapping metabolic domains/stringent phenomenon)

Alteration in structure of multifunctional protein from Chinese hamster ovary Jeffrey N. Davidson and David 1731-1735 cells defective in pyrimidine biosynthesis [carbamoyl-phosphate synthase Patterson (glutamine)/aspartate carbamoyltransferase/dihydro-orotase/intracellular proteolysis]

Identification of the messenger RNAs coding for the gag and env gene products Ganes C. Sen, Steven W. Smith, 1736-1740 of the murine mammary tumor virus (translation in vitro/molecular Stuart L. Marcus, and Nurul H. hybridization/immunoprecipitation/type B oncornavirus) Sarkar

Further studies on the mode of action of the heme-controlled translational Cesar de Haro and Severo Ochoa 1741-1745 inhibitor (polypeptide chain initiation/protein phosphorylation/eukaryotic initiation factor 2 kinase/eukaryotic initiation factor 2 stimulating protein/ternary complex formation)

Accelerated clearance of low-density and high-density lipoproteins and retarded Robert W. Mahley, Karl H. 1746-1750 clearance of E apoprotein-containing lipoproteins from the plasma of rats Weisgraber, Thomas L. Innerarity, after modification of lysine residues (lipoprotein catabolism/protein and Herbert G. Windmueller modification/hepatic uptake/liver metabolism)

Release of in vitro-synthesized poly(A)-containing RNA from isolated rat liver Raman K. Roy, Andrew S. Lau, H. N. 1751-1755 nuclei: Characterization of the ribonucleoprotein particles involved Munro, B. Surendra Baliga, and [transcription and processing of RNA/oligo(dT)-cellulose chromatography/ Satyapriya Sarkar nucleocytoplasmic transport of poly(A)-containing RNA]

Purification to homogeneity of camel pituitary pro-opiocortin, the common Sadao Kimura, Randolph V. Lewis, 1756-1759 precursor of opioid peptides and corticotropin (endorphins/high- Louise D. Gerber, Larry Brink, performance liquid chromatography/fluorescamine) Menachem Rubinstein, Stanley

Stein, and Sidney Udenfriend Direct chemical method for sequencing RNA (RNA chemistry/dimethyl Debra A. Peattie 1760-1764

sulfate/diethyl pyrocarbonate/hydrazine/aniline)

Prostaglandin D2 formation by malignant melanoma cells correlates inversely F. A. Fitzpatrick and D. A. 1765-1769 with cellular metastatic potential (B16 F1 cells/B16 Flo cells/platelet-tumor Stringfellow interaction/prostaglandin synthesis deficiency)

Detection and partial sequence analysis of gastrin mRNA by using an Barbara E. Noyes, Moshe Mevarech, 1770-1774 oligodeoxynucleotide probe (oligonucleotide synthesis/mRNA/cDNA/ Rhona Stein, and Kan L. Agarwal nucleotide sequencing/oligonucleotide hybridization)

BIOPHYSICS

Conformation of an oligopeptide in phospholipid vesicles (membrane proteins/ B. A. Wallace and E. R. Blout 1775-1779 NMR/circular d ichroism/hydrophilic and hydrophobic effects/protein fold ing)

Ultrasonic absorption evidence of structural fluctuations in viral capsids Roger Cerf, Bernard Michels, 1780-1782 (icosahedral viruses/pH-induced transitions/spontaneous motions in Jean-Alain Schulz, Jean Witz, capsids/ultrasonically detected volume change) Pierre Pfeiffer, and Leon Hirth

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