WHO/NMH/CHP/CPM/05.4
Global Alliance against Chronic
Respiratory Diseases (GARD)
Report of the General Meeting
Geneva, Switzerland, 10-11 May 2005
Noncommunicable Diseases and Mental Health Department of Chronic Diseases and Health Promotion Chronic Diseases Prevention and Management
Chronic Respiratory Diseases and Arthritis
2
© World Health Organization 2006
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Acknowledgements WHO wishes to acknowledge the help of Ms Anna Bedbrook and Mrs Marie-Christine Nedelec in the organization of the meeting.
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Contents 1. Preamble............................................................................................................................................................... 4 2. Introduction ........................................................................................................................................................ 4
2.1 GARD stepwise approach .......................................................................................................................... 5 3. Building and promoting the Alliance ............................................................................................................ 6
3.1 Participant profiles...................................................................................................................................... 6 3.2 Atlas of chronic respiratory diseases......................................................................................................... 6 3.3 GARD logo ................................................................................................................................................. 7 3.4 GARD web site........................................................................................................................................... 7 3.5 Article in a scientific journal ..................................................................................................................... 8 3.6 Government and private-sector relations in preparation for the launch.................................................. 8
3.6.1 Issues involved in planning the launch ................................................................................................ 8 3.6.2 Discussion .............................................................................................................................................. 8
4. Country activities................................................................................................................................................ 9 4.1 Standardization of treatment: the WHO Stop TB approach .................................................................... 9 4.2 Practical Approach to Lung health (PAL) project in Tunisia.................................................................. 9 4.3 Primary health centre survey in Cape Verde .......................................................................................... 10 4.4 Primary health care survey in Ryazan (Russian Federation) ................................................................. 10
5. GARD action plan............................................................................................................................................ 11 5.1 Working group 1: Burden, risk factors and surveillance of chronic respiratory diseases ................... 11
5.1.1 Products available at WHO................................................................................................................. 12 5.1.2 Deliverables proposed for Step 1........................................................................................................ 12
5.2 Working group 2: Health promotion and prevention of chronic respiratory diseases ......................... 13 5.2.1 Products available at WHO................................................................................................................. 13 5.2.2 Deliverables proposed for Step 1........................................................................................................ 13
5.3 Working group 3: Diagnosis of chronic respiratory diseases ................................................................ 14 5.3.1 Products available at WHO................................................................................................................. 14 5.3.2 Deliverables proposed for Step 1........................................................................................................ 14
5.4 Working group 4: Control of chronic respiratory diseases and access to drugs................................... 14 5.4.1 Products available at WHO................................................................................................................. 15 5.4.2 Action plans. ........................................................................................................................................ 15 5.4.3 Availability and accessibility of drugs for all patients with chronic respiratory diseases .............. 16 5.4.4 National action plan coordination and coordinator ........................................................................... 16 5.4.5 Deliverables proposed for Steps 1, 2 and 3........................................................................................ 16
5.5 Working group 5: Paediatric chronic respiratory diseases .................................................................... 16 5.5.1 Products available at WHO................................................................................................................. 17 5.5.2 Discussion ............................................................................................................................................ 17
5.6 Working group 6: Awareness and advocacy for chronic respiratory diseases ..................................... 17 5.6.1 Products available at WHO................................................................................................................. 17
5.7 Research needs and genomics ................................................................................................................. 18 5.7.1 World Health Assembly resolution .................................................................................................... 18 5.7.2 Promotion of WHO’s role in genomics research and facilitation of exchanges between developed and developing countries ................................................................................................................................... 18
6. General discussion ........................................................................................................................................... 19 7. Issues related to Terms of Reference............................................................................................................. 19
7.1 Discussion ............................................................................................................................................ 20 8. References........................................................................................................................................................... 21 9. List of participants .......................................................................................................................................... 22 10. Annex: GARD Participants as of May 2005………………………………………… ………………. 25
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1. Preamble The enormous human suffering caused by chronic respiratory diseases was recognized by the Fifty-third World Health Assembly, which requested the WHO Director-General to continue giving priority to the prevention and control of noncommunicable diseases, including chronic respiratory disease, with special emphasis on developing countries and other deprived populations.1
After several consultations (WHO Headquarters, Geneva, 11-13 January 2001 (1); Montpellier, 11-12 February 2002 (2); Montpellier, 27-28 July 2002 and Paris, 10 June 2003 (3); WHO Headquarters, Geneva, 17-19 June 2004 (4)), the Global Alliance against Chronic Respiratory Diseases (GARD) was approved by WHO and the first GARD meeting was held at WHO Headquarters, Geneva, on 18-19 January 2005 (5).
This report summarizes the consultation of experts from 33 governmental and nongovernmental organizations who participated in the General Meeting of GARD (WHO Headquarters, Geneva, 10-11 May 2005).
2. Introduction Dr Robert Beaglehole, Director, Department of Chronic Diseases and Health Promotion, Noncommunicable Diseases and Mental Health, World Health Organization, opened the meeting and welcomed the participants. Chronic respiratory diseases are high on the global health agenda. WHO has a mandate from the World Health Assembly to address the issue, and Member States give high priority to chronic respiratory diseases. GARD needs to prepare a comprehensive action plan and provide rational and integrated advice. Its work plans should be clear and unambiguous. Dr Beaglehole proposed that recommendations should be phased out and replaced by a stepwise approach in order to make best use of the additional resources which will be made available. The Framework Convention on Tobacco Control started with a simple approach and was transformed into a global action plan after a number of years.
However, it is important to create an integrated action plan with other chronic diseases, such as cancer, cardiovascular disease and diabetes. This is essential in low-income and middle-income countries, where separate action plans are not feasible, partly because of limited resources. Thus, the integrated approach should be extended to all chronic diseases, particularly since many of them share similar risk factors. It is more important to assess all diseases and risk factors globally than to determine risk factors individually.
GARD should be represented in all countries, although it is of particular interest to low-income and middle-income countries. More participants should be recruited from those countries. The gender balance among representatives should also be considered.
Dr Nikolai Khaltaev, Responsible Officer, Chronic Diseases Prevention and Management, WHO, said that the meeting was intended to formalize the GARD structure, organization and launch. The Alliance should focus on an integrated approach to chronic diseases, with chronic respiratory diseases as one component.
For this meeting, the participants nominated Dr Jean Bousquet, France and Dr Ronald Dahl, Denmark to serve as Co-Chairs and Dr Bruce Pfleger, United States of America and Dr Paolo Matricardi, Italy, to serve as Co-Rapporteurs.
1 World Health Assembly resolution WHA53.17 of 20 May 2000, endorsed by all WHO Member States (191
at that time).
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2.1 GARD stepwise approach GARD is to adopt a stepwise approach with short-term (Step 1), medium-term (Step 2) and long-term (Step 3) objectives and action plans (Fig. 1). Specific, measurable deliverables will be proposed for each step.
In Step 1, (2005-mid-2006), GARD will draw up a list of priorities and an action plan to be used by national coordination groups in order to build up a country-based approach (Fig. 2)
In Step 2, (mid-2006-end 2008), the integrated GARD action plan will be developed and pilot demonstration studies will be started in countries.
In Step 3, (2007-2010), the GARD action plan will be integrated into the global chronic disease action plan, adapted as necessary in the light of the pilot studies and implemented in a number of countries.
Fig. 1
GARD stepwise approach
GARD stepwise approach
GARD priorities
Integrated GARD action plan
Integrated NCD/GARD
action plan
Step 1Step 2
Step 3
2005 2006 2007 2008 2009 2010
Pilot studies in countries
GARD action plan in countries
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Fig. 2
GARD Step 1 action plan
WG – Working Group; CRD – chronic respiratory disease; PAA – Prevention of Allergy and Allergic Asthma; PFT – pulmonary function testing; PAL – Practical Approach to Lung health; PALSA – Practical Approach to Lung health in South Africa; COPD – chronic obstructive pulmonary disease; GIFT – WHO Global Initiative for Treatment of Major Chronic Diseases.
3. Building and promoting the Alliance During the first GARD meeting (WHO Headquarters, 18-19 January 2005), several proposals were made for building and promoting the Alliance. These proposals were updated and presented at the current meeting.
3.1 Participant profiles Dr Eva Mantzouranis presented a template to be used as a guide for illustrating the profile of the GARD participant organizations. The information submitted should include the name of the organization, the year it was established, the president or a contact individual within the organization, the title of the organization's official journal(s) (if any), the URL of its web site, its mission, the category of organization, the interest sections of its assemblies, the number of members and their representation in the WHO regions. The participants' profiles will be posted on the GARD web site.
Each organization will revise the draft sent by Dr Mantzouranis and sign an agreement form authorizing the information to appear on the GARD web site. Forms should be received by the WHO GARD secretariat office before the end of July 2005. The participants' profiles form part of the GARD Step 1 action plan (Fig. 2).
3.2 Atlas of chronic respiratory diseases Work on the atlas will begin soon, but it will not be completed in the period covered by the Step 1 action plan.
WG1
• inventory of studies
• risk factors
• prevalence/morbidity
• economic burden
• CRD module in STEP
• CRD module in Infobase
WG2
• tobacco ban action plan
• update Prevent Allergy Asthma
• healthy indoor environment
WG3
• Pulmonary function tests
• simple allergy diagnosis
WG4
• PAL
• PALSA
• asthma
• rhinitis
• COPD
• infections in COPD
• Pulmonary Hypertension
• occupational CRD
• sleep CRD
• accessibility of drugs (GIFT)
WG5
• inner city asthma programme
• priorities in childhood asthma
WG6
Genomics
Promotion of the Alliance
• GARD participant profile
• GARD logo
• GARD web site
• GARD atlas
• GARD launch documents
Description of some priorities
06-05 09-05 10-05 12-05 02-06 04-06
GARD Step 1 action plan
Step 2
Continuous update
Launch
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3.3 GARD logo Organizations are asked to propose an eye-catching logo for GARD before the end of June 2005. The proposed designs will be circulated and a decision will be taken at the next GARD meeting.
3.4 GARD web site Dr Bruce Pfleger presented the new web site for chronic respiratory diseases, which is being developed at WHO. The main sections on the site will cover GARD, chronic obstructive pulmonary disease, asthma, other chronic respiratory diseases and publications. The home page includes information on the structure and financing of the Alliance and will include the participant profiles.
Various ways of navigating the WHO site were discussed, as were links to the developing site. The web site will list the GARD participants and provide links to their own web sites. Any site may link to WHO, as long as the link is not used for advertising or endorsement. WHO will only link to external partners if it is working closely with them.
The web site will be developed initially in English; it may be translated into one or more of the other five United Nations official languages in future, if the necessary resources become available. Documents and reports in English or other languages will be posted in PDF and HTML formats. Each document must be approved by the national coordinator of the originating country.
The launch of the GARD web site is part of the Step 1 action plan and should take place before 1 September 2005. The home page is shown in Fig. 3. Fig. 3
GARD home page: http://www.who.int/respiratory/gard/en
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3.5 Article in a scientific journal Dr Bousquet agreed to draft a short paper about GARD for submission to a scientific journal (The Lancet and the British Medical Journal were suggested: Dr Bousquet proposed the New England Journal of Medicine).
3.6 Government and private-sector relations in preparation for the launch
Mr Igor Rozov (Government, Civil Society and Private Sector Relations, External Relations and Governing Bodies, WHO) explained that he and his colleagues had helped to launch a number of initiatives similar to GARD. On the basis of his experience, he raised a number of issues which stimulated further discussion.
3.6.1 Issues involved in planning the launch A partnership must have an identified purpose and clear objectives, which must be accepted by the WHO Member States. For example, the Vision 2020 campaign, involving about 30 nongovernmental organizations and coordinated by the WHO Prevention of Blindness and Deafness unit, had stated early on that its purpose was to eliminate preventable blindness which, it is estimated, constitutes 80% of the overall burden.
When considering the financing needed to initiate a launch, the partnership must pay particular attention to long-term financing. This can best be achieved by linking the activities surrounding the launch with resource mobilization.
A memorable name is needed for the Alliance. Slogans such as “the right to sight” were used for Vision 2020. “GARD, the right to breathe” was suggested.
The communication campaign should be carefully planned in advance and include the following: a press kit, consisting of a press release and fact sheets; a video news release, prepared in advance and preferably involving prominent public figures; carefully planned media events, with the participation of prominent figures to attract media attention. A panel, consisting of around four experts and the Minister of Health of the host country, should hold a press conference for the launch.
The site of the launch is critical. It should be a major developing country, such as India or China, where the burden of chronic respiratory disease is high and GARD prevention and treatment initiatives could have a strong impact. The launch must enjoy the full support of the Government. Regional and public relations launches should follow. These help to bring the messages of the partnership before the targeted audiences.
Public relations campaigns are expensive, but WHO can conduct a campaign more effectively and at lower cost than external agencies. WHO has a list of 5000 media outlets for the press kit. A campaign including production of a press kit, translation into 1-5 languages, distribution of the kit, production of a video and monitoring of its exposure in the media would cost around US$50 000. A similar campaign using an external public relations organization would cost between US$220 000 and US$250 000.
Raising awareness is not enough by itself. A plan of action, targeted initially at 1-2 regions rather than globally, will coordinate better with the public relations campaign.
3.6.2 Discussion A participant asked whether the launch would attract money for local action plans only, or also for regional or global use. One solution would be to ensure that a percentage of local funds goes to the region.
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The location of the launch was discussed again. It was pointed out that a launch in Geneva would have some advantages: WHO’s presence would be obvious, some 250 press correspondents are located nearby, and some costs would be reduced. However, the advantages of launching in China or India were again stressed.
A final comment was made pointing out that the success or otherwise of a launch could not be predicted in advance: a high-impact global story, such as the Asian tsunami of December 2004, would inevitably dominate the media.
4. Country activities 4.1 Standardization of treatment: the WHO Stop TB approach The Stop TB Partnership represents an alliance of various groups and individuals working in the field of tuberculosis, coordinated by the WHO Stop TB Department. Dr Salah-Eddine Ottmani of the Stop TB Department stressed the significance of tuberculosis around the world. Tuberculosis rates are still increasing, but globally the rate of increase is slowing down, albeit with considerable differences between countries.
Despite the great variations between health care systems, it is essential to follow universal standards of diagnosis and treatment. Diagnostic standards cover laboratory findings and the need to consider concomitant conditions (e.g. HIV/AIDS). Treatment should take a patient-centred approach, and patients’ response to therapy should be monitored. Standards should be consistent with tuberculosis guidelines: at present, however, there are around 80 different guidelines, which should be combined into an international standard.
All health care providers are responsible for providing adequate treatment and ensuring the best possible compliance. Treatment is now standardized, but a patient-centred approach should be developed for all patients. New and recurring tuberculosis cases and their treatment outcomes should be reported to local public health authorities in line with national legislation.
4.2 Practical Approach to Lung health (PAL) project in Tunisia Dr Ali Ben Kheder reported the results of a PAL pilot study in Tunisia. PAL was officially approved by the Tunisian Government in December 2003, and a pilot study was carried out in four districts of Tunis: the baseline study was conducted in January-February 2004. The training period consisted of a two-day course for 73 general practitioners (of the 98 originally proposed). The impact study was carried out in March-April 2004 to assess the effect of training on the health of patients over five years of age with respiratory symptoms.
Selected results show that respiratory patients accounted for 36% of all patients in the baseline study and 31% of the patients in the impact study. At baseline, 58.3% of the patients had acute bronchitis; 34.3% acute upper respiratory infections; 4% asthma; 2.5% pneumonia; 1.4% chronic obstructive pulmonary disease; 0.2% tuberculosis.
When the patient population at the impact stage was compared with the baseline stage, significant increases were seen in diagnoses of asthma, chronic obstructive pulmonary disease and tuberculosis. Significant changes were also seen in the syndrome used for diagnosis (cough, dyspnoea, sputum). Referrals rose significantly, as well as requests for sputum smear examination. A significant decrease was observed in the number of drugs used per patient and the number of antibiotics prescribed, which resulted in an average cost saving of 19.3% on prescriptions. Total direct costs decreased as well.
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4.3 Primary health centre survey in Cape Verde Dr José Rosado Pinto described the health system in Cape Verde, which is well-developed in comparison with other sub-Saharan African countries. In particular, there are physicians in all primary health centres, and the hospitals are equipped for the management of patients with chronic respiratory diseases and allergies.
An epidemiological survey showed that the prevalence of asthma is around 8% in children. Five per cent of children admitted to paediatric emergency care units are asthmatic patients. A protocol for assessing the prevalence of major chronic respiratory diseases in Cape Verde has been drawn up by Isabella Annesi-Maesano, Nikolai Khaltaev and Paolo Matricardi. The Portuguese version of the protocol (adapted for local use in Cape Verde) was presented during the meeting.
A two-stage project is to be developed under the responsibility of WHO and the Ministry of Health, with Portuguese collaboration. The first stage will examine the prevalence of respiratory diseases, using a population-based survey of 4000 inhabitants. The survey will cover chronic obstructive pulmonary disease, asthma, allergic rhinitis, tuberculosis and pneumonia. Spirometry will be applied to a subsample. During the second stage, patients with respiratory symptoms will be evaluated by means of a questionnaire and spirometry measurement by both general practitioners and WHO-recommended respiratory experts. The problem of underdiagnosis and undermanagement of respiratory diseases at the primary health care level will be addressed. Future plans include expansion of the study to other Portuguese-speaking populations.
4.4 Primary health care survey in Ryazan (Russian Federation) Dr Alexander Chuchalin reported on the results of the Primary Health Care survey carried out between October 2004 and March 2005 in Ryazan (Russian Federation) in close collaboration with Dr Nikolai Khaltaev. The Ryazan region is approximately 175 km south of Moscow. It is 39 600 km2 in size. Its population is 1 306 600 (urban population: 68.4%). It is divided into 25 districts and includes 12 towns, 26 urban-type settlements and 456 rural administrations. The capital is Ryazan, with 536 900 inhabitants.
Two population centres, Scopin district with 40 000 people and Shilovo district with 60 000 people, were chosen to assess the prevalence of respiratory diseases. The region’s health care system consists of 104 hospitals, 65 outpatient clinics and 792 feldsher stations (a small clinic, usually with one medical assistant). A multistage study is underway to assess the burden of chronic respiratory disease. Lung function tests were carried out on around 45% of subjects. Risk factors were assessed.
A pilot study was conducted in October 2004 to finalize the questionnaire and protocol and recruit the necessary health professionals. A population-based survey was conducted in primary health care settings towards the end of 2004, involving residents over five years of age. The questionnaire covered symptoms, diseases, diagnoses, comorbidity, sociodemographics and risk factors. The survey was then conducted in households, likewise covering subjects over five years of age.
In February-March 2005, a clinical survey and lung function test were conducted in 16 randomly selected primary health care settings. All patients from the household stage were included. Selected results show that males are at far greater risk, owing to the high prevalence of smoking (60% of male adults and 8% of male children smoked) and exposure to dust at work (40% of males and 20% of females). The prevalence of dyspnoea, cardiovascular disease and chronic respiratory diseases is twice as high in women as in men. Sputum
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production occurs in 14% of men and 4% of women. The prevalence of chronic obstructive pulmonary disease, at 1.6%, is similar to other parts of the Russian Federation. Low pulmonary function was found in 14% of the population. The underuse of asthma treatment is significant, since less than 1% of asthmatics were treated by inhaled corticosteroids. Theophylline was the most common drug administered.
5. GARD action plan During the first GARD meeting (5) working groups were set up to develop an action plan, using existing materials from WHO or other action plans to meet the objectives of GARD. During the current meeting, Step 1 action plan deliverables were proposed for each working group so that they could be prepared by the end of 2005. The action plan will be used by national coordination groups in order to create a country-based approach (Fig. 4). Some proposals for Steps 2 and 3 were also put forward.
Fig. 4 From GARD action plan to national action plan
5.1 Working group 1: Burden, risk factors and surveillance of chronic respiratory diseases
Chair: Dr Giovanni Viegi; Vice-Chair: Dr Sonia Buist This working group should work closely with working groups 2 and 6 on prevention and awareness. Dr Giovanni Viegi presented data based on the European lung white book (6). This book, produced by the European Respiratory Society, is a comprehensive survey of lung health. The text includes a preliminary inventory of studies indicating the prevalence of respiratory diseases and risk factors and a preliminary inventory of studies on the economic burden of disease. Dr Viegi also presented recent epidemiological data from the European Community Respiratory Health Survey, from the Obstructive Lung Disease in Northern
GARD National
Action plan endorsed
by Ministry of Health
GARD National
Action plan
GARD
Action plan
National
Coordination
Members of national societies
respiratory
allergy
ENT
GPs
pharmacists
others
Members of NGOs
Patients
Member of Health Ministry
Others if required
From GARD action plan to National action plan
Test in selected countries
(WHO regions)
with indicators of success
12-05
06-06
12-06
Starting 06 to 12-06
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Sweden (OLIN) studies, and from the Po Delta and Pisa studies. He drew particular attention to the 2003 article in Chest by Halbert RJ et al. (7), which clearly showed that the WHO expert opinions on which the Global Burden of Disease report (8) is based may underestimate the true figure by up to a factor of 10. Finally, Dr Viegi presented a list of preliminary deliverables.
Important activities in the GARD epidemiology project include linking its results with similar efforts at WHO, such as the Surveillance of Risk Factors (SuRF) project which, in collaboration with the chronic respiratory diseases unit, is adding the chronic respiratory disease modules to its database, and the STEPwise approach to Surveillance of risk factors (STEPS) project. Methodologies must be standardized: epidemiology studies need to employ standard disease definitions and methods for diagnosis (at present, estimates of chronic obstructive pulmonary disease prevalence may be incorrect owing to a lack of uniformity). A comprehensive approach should be adopted, employing tools which also capture other diseases associated with the same risk factors, such as cardiovascular disease. The number of patients should be counted as well as the number of diseases, as the latter approach may mean that the same patient is counted more than once. Finally, Dr Viegi emphasized the usefulness of the Burden of Obstructive Lung Disease (BOLD) study (9) for capturing economic cost data. 5.1.1 Products available at WHO
• A standardized, validated questionnaire to assess national capacity for surveillance, prevention and control of chronic respiratory diseases.
• A methodology for collecting existing information on the prevalence of chronic diseases and their risk factors (Global InfoBase).
• A methodology for acquiring new information on the prevalence of chronic diseases and their risk factors (STEPwise approach).
• A methodology for assessing patients with respiratory symptoms at the primary health care level.
5.1.2 Deliverables proposed for Step 1 The first deliverables for Step 1 should include preliminary inventories of existing studies of prevalence rates of diseases and risk factors, and existing studies providing data on the economic burden of disease.
Dr Sonia Buist noted that better awareness of chronic respiratory diseases will actually increase the number of patients identified as having chronic respiratory disease, as well as the burden on health services, although one of the goals of GARD is to reduce the burden of chronic respiratory diseases. This point should be clearly stated when the long-term goals of GARD are proposed.
Dr Ali Kocabas gave details of the prevalence of chronic obstructive pulmonary disease in Adana, Turkey, taken from the BOLD study (9). Physicians diagnosed chronic obstructive pulmonary disease in 5.7% of adults over 40 years of age. However, if the criteria of the Global Initiative for Chronic Obstructive Lung Disease are used, there are indications of a very substantial underdiagnosis of this disease.
Dr Eva Mantzouranis gave an update on the chronic respiratory diseases module of the WHO Global Infobase. Asthma will be the first module to be added to the infobase, using data from the International Study of Asthma and Allergy in Children (ISAAC) and the European Community Respiratory Health Survey (ECRHS). There are considerable
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differences in prevalence and incidence of asthma within a single country, and mean values may not be sufficient. The Global Burden of Asthma report (10) may be difficult to add to the module, because it gives the overall prevalence or incidence within a country. However, the figures from this document could be used for other purposes, such as the web site. For rhinitis, data from the ISAAC and ECRHS studies will also be used.
5.2 Working group 2: Health promotion and prevention of chronic respiratory diseases
Chair: Dr Michael Boland; Vice-Chair: Dr Adnan Custovic Dr Michael Boland commented on health promotion and disease prevention. National governments have various priorities. GARD needs to create a situation where environmental control and a ban on tobacco smoking are at the top of the agenda. There is also a need to generate enthusiasm about the impact of GARD and convince the world that GARD is really going to make a difference to health. Chronic obstructive pulmonary disease is underdiagnosed and undertreated, and affects many poor people.
Dr Boland made some proposals for an optimal action plan at the country level. The national coordinator will be the champion of the campaign and should have some access to the Government or parliament. The national coordinator should have an appropriate support structure.
Everyone in the country – patients, physicians and legislators – should be educated about the importance of chronic respiratory diseases. Trade unions and workers’ representatives are the campaign’s natural allies, defending people’s right to work in a smoke-free environment. Public education campaigns must be conducted for several years in order to form public opinion before new legislation is adopted, and successes must be widely publicized.
Indoor air pollution is of great concern, since over 2 billion people in the developing world burn traditional biomass fuels indoors for cooking and heating and are thus exposed to health risks. WHO estimates that increased exposure in this group leads to an estimated 1.6 million premature deaths each year, largely among women and children. Chronic respiratory diseases are an environmental health issue. The Partnership for Clean Indoor Air (11) has the mission of improving health, livelihood and quality of life by reducing exposure to air pollution, primarily among women and children, from household energy use. 5.2.1 Products available at WHO
• A series of tools produced by the Tobacco Free Initiative for the implementation of the Framework Convention on Tobacco Control.
• A document on prevention of allergy and allergic asthma (12). • The Indoor Air Pollution and Exposure Database: Household Pollution Levels in
Developing Countries. 5.2.2 Deliverables proposed for Step 1 Tobacco ban action plan: the action plan for the Framework Convention on Tobacco Control and plans which have been successful at the country level (e.g. in Ireland) should be reviewed in order to identify simple measures which can be used at Step 1. The number of countries where GARD helps to implement tobacco-free initiatives and encourage ratification of the Framework Convention on Tobacco Control may provide an outcome measure for Step 3.
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Improvement of indoor air quality in dwellings, in particular in developing countries, to reduce chronic obstructive pulmonary disease: tobacco smoke is a major cause of indoor air pollution in high-income countries. However, in many middle-income and low-income countries (e.g. China), chronic obstructive pulmonary disease is a major disease in nonsmoking women because of indoor heating and cooking in dwellings with insufficient ventilation. Simple proposals should be made to improve ventilation in new buildings and, where possible, in older ones (Step 1). Any barrier that may apply to this action plan should be discussed at both national and regional levels. For Step 2, GARD should produce a document on indoor air pollution.
Allergy prevention: the WHO publication on prevention of allergy and allergic asthma (12) was based on a WHO workshop in January 2002. For Step 2, an update will be proposed by members of working group 2.
5.3 Working group 3: Diagnosis of chronic respiratory diseases Chair: Dr Klaus Rabe; Vice-Chair: Dr Sally Wenzel The goal of this working group is to develop an integrated action plan for the diagnosis of chronic and related allergic respiratory diseases. However, this cannot be achieved in Step 1.
Dr Klaus Rabe presented a strengths/weaknesses/opportunities/threats (SWOT) analysis for the diagnosis of chronic respiratory diseases. The strengths are a broad approach, global backing, the prevalence of these diseases and the simple messages which can be disseminated about lung function and allergies. The weaknesses are the heterogeneity of chronic respiratory diseases, countries and providers. There are opportunities to combine our efforts, put chronic respiratory diseases on the global map, introduce pulmonary function tests for all and increase awareness of allergies. The threats are the timeless nature of the chronic disease problem, the issue of deliverables and implementation.
The Practical Approach to Lung health (PAL) is used in primary health centres. It is a syndromic approach to respiratory symptoms: however, where possible, objective methods should be added to supplement the symptomatic approach.
5.3.1 Products available at WHO • Diagnostic algorithms in the PAL guidelines.
5.3.2 Deliverables proposed for Step 1 Availability and accessibility of pulmonary function tests for all patients is an essential part of GARD. Working group 3 should work closely with the Forum of International Respiratory Societies for this purpose and prepare a report by 31 December 2005.
Availability and accessibility of simple and affordable allergy tests is an important part of GARD. Working group 3 should prepare a report by 31 December 2005.
5.4 Working group 4: Control of chronic respiratory diseases and access to drugs
Chair: Dr Jean Bousquet; Vice-Chairs: Dr Eric Bateman, Dr Leonardo Fabbri, Dr Chris Van Weel GARD’s principal role is not to devise new guidelines, but to catalogue existing guidelines and lend the authority of organizations and WHO to certain of them. The goal of this working group is to create an integrated action plan for the control of chronic respiratory and related allergic diseases, which should be implemented in Step 2.
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5.4.1 Products available at WHO • Practical Approach to Lung health (PAL) guidelines. • Global Initiative for Treatment of Major Chronic Diseases (GIFT).
5.4.2 Action plans. Action plans need to be tailored to low-income, middle-income and high-income countries or regions within countries.
In areas where communicable diseases are prevalent and primary health centres exist, the PAL approach will be used. The number of countries where this approach is implemented may be one of the deliverables for years 3 and 5.
In areas where there is also an HIV epidemic, the Practical Approach to Lung health in South Africa (PALSA) will be used. The number of countries where PALSA is implemented may be one of the deliverables for years 3 and 5.
In developed countries, PAL is only applicable to some low/middle-income areas. A comprehensive group of diseases should be considered, including asthma/rhinitis, chronic obstructive pulmonary disease and its related infections, occupational lung diseases, chronic respiratory diseases associated with sleep disorders and pulmonary vascular disease. Additional diseases can be added depending on the country.
The proposed group of experts should review the available management plans which have already been successfully introduced in various countries, and establish a list of priorities by 31 December 2005. For each disease, the group of experts will propose a list of up to six priorities.
The following process is proposed. For each disease, two or three experts will review the available management plans after the European Respiratory Society congress (Copenhagen, 21-22 September 2005). The final list of priorities will be drawn up by 30 October 2005 and will then be submitted to the group of experts (including health economists) by 15 December 2005. Fig. 5
Distribution of diseases depending on the economic status of the country
communicable
diseases
noncommunicable
diseases
low -incomecountry
middle -incomecountry
high -incomecountry
Distribution of diseases depending on the
economic status of the country
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5.4.3 Availability and accessibility of drugs for all patients with chronic respiratory diseases
This is essential. Members of this working group should meet the members of the Global Initiative for Treatment of Major Chronic Diseases (GIFT) and prepare a report by 31 December 2005. The working group should collaborate closely with the International Union Against Tuberculosis and Lung Disease, which is launching an important action plan on drug donations for asthma (beclomethasone and salbutamol).
5.4.4 National action plan coordination and coordinator In order to initiate changes in action plans at the country level, coordination should take place between GARD and the national coordination group, leading to a national GARD action plan to be approved by the Minister of Health. Resulting action plans should be tested in selected countries, with success indicators. Implementation of the final action plan should begin by 2007.
The GARD action plan should be applied at the country level. There is therefore a need to establish working groups in the different countries, with a national action plan coordinator. The group will include members of societies of respiratory, allergic, paediatric, ear/nose/throat and occupational diseases; members of societies of internal medicine, general practitioners, public health (including pharmacoeconomics) and lung health associations; other health care workers; patients and representatives from the Ministry of Health (Fig. 4).
The national coordination group will assess the needs of the country in question, review the GARD action plan and identify specific needs and proposals required to adapt it to the country’s needs and develop a country-specific action plan. 5.4.5 Deliverables proposed for Steps 1, 2 and 3 The following deliverables should be proposed: a written action plan for Step 1; an integrated action plan for Step 2; number of countries with a national coordination group (after one year (Step 1), three years (Step 2) and five years (Step 3)); number of countries where the GARD action plan has been approved by the Ministry of Health (after three years (Step 2) and five years (Step 3)); number of countries where the GARD action plan has been implemented (after five years (Step 3)).
5.5 Working group 5: Paediatric chronic respiratory diseases Chair: Dr Carlos Baena-Cagnani; Vice-Chairs: Dr Erkka Valovirta, Dr Estelle F. Simons The GARD action plan, as applied to children, should consider low-income, middle-income and high-income settings, and establish short-term, medium-term and long-term goals. The focus initially should be on asthma and rhinitis, the major chronic respiratory diseases in children.
An asthma management plan for children based on the inner-city asthma management plan will be used in low-income areas of developed countries and in suburban areas of developing countries. The deliverable will consist of a short action plan document (10 printed pages or shorter) (Step 1). In developed countries, the short-term action plan should list up to six priorities for asthma. The group of experts should review the available management plans which have already been successfully introduced in various countries, and establish a list of priorities for Step 1. Rhinitis is a significant comorbid condition of asthma in children, and should be taken into consideration as well. An integrated recommendation for diagnosing and treating asthma in schoolchildren should be prepared for Step 2. GARD should use data from the ISAAC phase III study for the prevalence of asthma and wheeze in children.
17
Epidemiological studies should begin in low-income areas where no data currently exist, in order to assess the prevalence and severity of childhood asthma. These studies should be discussed and proposed between the Working groups 1 and 5, at step 2. Management of recurrent wheezing in infants and in preschool children should be considered separately. 5.5.1 Products available at WHO
• None 5.5.2 Discussion The GARD recommendations should cover the best available options, but alternatives should be included for low-income and middle-income countries. Research is needed to determine the prevalence and severity of asthma in areas where no data are available. More information and action plans are required about passive and active smoking in children, particularly in developing countries. Lung function tests cannot be performed in children under 5-6 years of age. Furthermore, many asthmatic children have normal pulmonary function tests. The importance of differential diagnosis was emphasized.
5.6 Working group 6: Awareness and advocacy for chronic respiratory diseases
Chair: Dr Claude Lenfant; Vice-Chairs: Mr Archie Turnbull, Dr Paul Van Cauwenberge The two guiding questions for GARD in relation to awareness are “who should be aware?” and “what should they be aware of?”. There are three target populations to which GARD must effectively convey its message.
Governments have a critical role to play, and WHO is in a good position to address them. The World Health Assembly will not consider GARD in 2005, but could do so in future years. The Bulletin of the World Health Organization could also prove an effective medium.
Physicians, although not able to cure chronic diseases, are still the key to implementation of GARD. The pharmaceutical industry can play a big role in education. However, there should be rules governing the interaction between GARD and the private sector (5).
Patients and the general public remain the ultimate focus of GARD. The media and the Internet will be of great importance. Asthma has benefited from the fact that many famous athletes have competed on the world stage despite having the disease. Chronic obstructive pulmonary disease has not benefited the same way, partly because of the stigma associated with it, since patients have brought the disease upon themselves. Nevertheless, the use of celebrities to raise public awareness should be explored. Education of children can be very effective, as they can strongly influence their parents and raise issues which will lead to the message of GARD. We also need to involve “important people” to raise awareness of GARD.
There are 192 Member States of WHO, with enormous differences in economic status and health systems. It is impossible to reach them all with a single message. For example, spirometry is generally recommended for diagnosis, but most people in the world do not have access to it. 5.6.1 Products available at WHO See references 1, 2, 3, 12, 13, 14, 15.
18
5.7 Research needs and genomics There are many gaps in the understanding of chronic respiratory disease. Research is needed in order to assess the disease burden and risk factors more effectively, improve surveillance and identify better methods of diagnosis, control and prevention.
5.7.1 World Health Assembly resolution At its fifty-seventh session in May 2004, the World Health Assembly adopted Resolution WHA57.13, in which it, inter alia: expresses the wish to promote the potential benefits of the genomics revolution for the health of populations in developed and developing countries alike; calls upon Member States to facilitate greater collaboration among all relevant partners; requests the Director-General to promote WHO’s role in collaboration with relevant partners, including the private sector, in convening regional and international forums, coordinating genomics research and facilitating exchanges between developed and developing countries; takes note of the recommendations in the report of the Advisory Committee on Health Research on genomics and world health (16).
5.7.2 Promotion of WHO’s role in genomics research and facilitation of exchanges between developed and developing countries Envirogenomics of Chronic Obstructive Lung Diseases (GENOCOLD):
GARD, thanks to its network of scientific societies in the fields of respiratory medicine, allergy and immunology, is in a unique position to coordinate global research on the role of environmental factors in genomics (envirogenomics) of chronic obstructive pulmonary disease. WHO has recognized the importance of collaborative efforts in genomics to improve health in all countries, including developing countries. Since lung cancer is often related to the environmental factors involved in chronic obstructive pulmonary disease, it seems best to include both diseases in GENOCOLD.
GENOCOLD will also facilitate exchanges between developed and developing countries and, since standardized protocols will be used around the world, there will be a transfer of knowledge to developing countries.
Research conferences on respiratory disease: the Fifty-seventh World Health Assembly requested the Director-General to facilitate the exchange of knowledge about genomics between developed and developing countries. GARD is able to comply with this request by establishing research conferences on respiratory diseases. All the conferences should follow the same format.
Attendance:
• scientists with significant grants on the topic from around the world • scientists from the private sector who are conducting major research activities
on the topic • at least 30% of the attendees will be from developing countries, with a focus
on young scientists who do not necessarily hold a research grant • members of funding organizations
• government representatives • representatives of the private and public sectors, including major foundations.
The genomic aspect of the various topics will be discussed, but ethical and public health issues, as well as practical guidance, should form part of each conference. It is
19
proposed that the conferences should last for three days. On day 1, participants will discuss their own research. On day 2, small working groups will seek possible collaborations with scientists and laboratories from developing countries. On day 3, each working group will present its conclusions, with proposals for collaborative studies; ethical and public health issues; knowledge transfer to developing countries. Proceedings or a summary report will be published in a peer-reviewed journal. Some topics of interest have already been selected: genomics in asthma, prevention of allergy and asthma.
6. General discussion The discussion of the reports of the working groups dealt with a number of important topics. Flexibility is of paramount importance for all GARD activities. Research is needed, particularly in relation to phenotypes and genetics.
Drug regulatory agencies should be represented, e.g. European Medicines Agency, United States Food and Drug Administration. Regional representatives and national coordinators are needed to provide stability for GARD. These should work with ministries of health, which have the power to change health care policy. Other ministries may be involved as well (e.g. environment, education, labour, research). Ministries should be asked to recommend national representatives to attend events.
A suggestion by Parliament to the Government that a national strategy group should be created was found to be important in some countries (e.g. Norway).
Working groups should involve nongovernmental organizations rather than individuals. Every working group should include patient representatives. Outreach action plans are needed for schoolteachers and school nurses.
7. Issues related to Terms of Reference Dr Paolo Matricardi said that the number of GARD participants had increased from 16 in January 2005 to 38 in May 2005. More organizations are expected to join. All participants have voting rights during the General Meeting.
A Committee was elected for the period up to the launch, including Dr Nikolai Khaltaev (WHO GARD Secretariat), Dr Jean Bousquet (Chair), Dr Ronald Dahl (Co-Chair), Dr Eric Bateman, Dr Michael Boland, Dr Claude Lenfant, Dr Ruby Pawankar, Mr Archie Turnbull and Dr Erkka Valovirta.
Possible amendments to the terms of reference were discussed pending formal approval by the Office of the WHO Legal Counsel.
The Chair of the General Meeting, the Co-Chair, the WHO Secretariat and other members selected by the General Meeting will form the Planning Group. The participants of the meeting discussed the possibility of having an Executive Board, as part of the Planning Group, which will meet at least three times a year. The responsibilities of this Executive Board would consist of preparing the reports and proposals to be discussed by the Planning Group and preparing the agenda of the GARD General Meetings. The Planning Group will be elected at the next meeting. All the WHO regions should be represented.
Participants of GARD are encouraged to make an annual voluntary financial contribution. This contribution is essential for the efficient functioning of the secretariat and the Alliance as a whole. Some nongovernmental organizations with limited resources may not be able to contribute financially. However, others could contribute by providing human resources, e.g. seconding staff to GARD.
20
7.1 Discussion GARD needs to be global and multidisciplinary. A wide representation on the Planning Group is very important. GARD is targeted at developing countries, so there should be representation from all WHO regions, but also from middle-income and low-income countries.
All major organizations should be represented on the Planning Group. It was proposed that the number of members should not exceed 12. There is no limit on the number of participants in the General Meeting.
Permanent and rotating members may be appointed (as is done in the European Commission’s Global Allergy and Asthma European Network). A balance must be maintained between specialists, regions, types of members and representation of developing countries.
The next General Meeting of GARD will take place in Beijing, People's Republic of China, in March 2006, immediately after the launch of GARD on 28 March.
21
8. References 1. WHO consultation on the development of a comprehensive approach for the prevention and control of
chronic respiratory diseases, 11-13 January 2001 (internal WHO document WHO/NMH/MNC/CRA/01.1). Geneva, World Health Organization, 2001.
2. Implementation of the WHO strategy for prevention and control of chronic respiratory diseases, Montpellier, 11-12 February 2002 (internal WHO document WHO/MNC/CRA/02.2). Geneva, World Health Organization, 2002.
3. Prevention and control of chronic respiratory diseases in low and middle-income African countries: a preliminary report (internal WHO document WHO/NMH/CRA/04.1). Geneva, World Health Organization, 2003.
4. Prevention and control of chronic respiratory diseases at country level: Towards a Global Alliance against Chronic Respiratory Diseases (GARD), Geneva, Switzerland, 17-19 June 2004 (internal WHO document WHO/NMH/CHP/CPM/CRA/05.1). Geneva, World Health Organization, 2004.
5. WHO Meeting on the Global Alliance against Chronic Respiratory Diseases (GARD), Geneva, Switzerland, 18–19 January 2005 (internal WHO document WHO/NMH/CHP/CPM/05.2). Geneva, World Health Organization, 2005.
6. Loddenkemper R, Gibson GJ, Sibille Y. European lung white book. Sheffield, European Respiratory Society Journals/European Lung Foundation, 2003.
7. Halbert RJ et al. Interpreting COPD prevalence estimates: what is the true burden of disease? Chest, 2003, 123:1684-92.
8. Murray CJL, Lopez AD. The global burden of disease. Geneva, World Health Organization/Harvard School of Public Health/World Bank, 1996.
9. http://www.kpchr.org/boldcopd/apps/default.aspx, accessed 30 December 2005. 10. Masoli M et al. The global burden of asthma: executive summary of the GINA Dissemination
Committee report. Allergy, 2004, 59(5):469-78. 11. www.PCIAonline.org, accessed 31 December 2005. 12. Prevention of allergy and allergic asthma, Geneva, 8-9 January 2002 (internal WHO document
WHO/NMH/MNC/CRA/03.2). 13. Preventing chronic diseases: a vital investment: WHO global report. Geneva, World Health
Organization. 2005. http://www.who.int/chp/chronic_disease_report/full_report.pdf, accessed 9 February 2006.
14. Global Initiative for Asthma. NHLBI/WHO workshop report: global strategy for asthma management and prevention, January 1995 (NIH publication No. 02-3659).
15. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO report, March 2001.:
16. Genomics and world health: report of the Advisory Committee on Health Research. Geneva, World Health Organization, 2002.
22
9. List of participants GARD participants1 Dr Ignacio J. ANSOTEGUI, International Association of Asthmology, INTERASMA, C/Aita Roman Urtiaga 19A, 48340 Amorebieta, Spain, email: [email protected]/[email protected] Professor Jean-Philippe ASSAL, President, Foundation Education and Research for Patient Education, 40, chemin de Conches, 1231 Geneva, Switzerland, email: [email protected] Professor Carlos BAENA-CAGNANI, World Allergy Organization (WAO), 555 East Wells Street, Suite 1100, Milwaukee, WI 53203-3823, United States of America, email: [email protected] Professor Eric BATEMAN, Groote Schur Hospital, University of Cape Town, Cape Town 7925, South Africa, email: [email protected] Professor Ali BEN KHEDER, Ministère de la Santé publique, Hôpital A. Mami Ariana, 2080 Ariana, Tunisia, email: [email protected] Dr Karl-Christian BERGMANN, Allergy-Center-Charite (ECARF), Clinic for Dermatology and Allergy, Luisenstr. 2-5, D-10117 Berlin, Germany, email: [email protected] Dr Michael BOLAND, Irish College of General Practitioners, 4/5 Lincoln Place, Dublin 2, Ireland, email: [email protected] Professor Sergio BONINI, IRCCS San Raffaele - Tosinvest Sanità, Research Center, Via dei Bonacolsi snc, 00163 Rome, ITALY, email: [email protected] Professor Jean BOUSQUET (Chair), Service des Maladies Respiratoires, INSERM U454, Hôpital Arnaud de Villeneuve, F-34295 Montpellier Cédex 5, FRANCE, email: [email protected] Dr A. Sonia BUIST, Pulmonary & Critical Care Medicine, Oregon Health & Science University, Mail Code UHN 67, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, United States of America, email: [email protected] Professor Alexander G. CHUCHALIN, National Institute of Pulmonology, 11th Parkovaya St, 32/61, Moscow 105077, Russian Federation, email: [email protected] Professor Ronald DAHL (Co-Chair), University Hospital of Aarhus, Dept of Respiratory Diseases, DK-8000 Aarhus, Denmark, email: [email protected] Professor Leonardo FABBRI, Section of Respiratory Diseases, University of Modena & Reggio Emilia, Largo del Pozzo 71, 41100 Modena, Italy, email: [email protected] Ms Birthe HELLQUIST, Head Nurse, Department of Respiratory Diseases, Aarhus University Hospital, 8000 Aarhus, Denmark, email: [email protected] Professor Guy JOOS, Dept. of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium, email: [email protected] Professor You-Young KIM, Korea Asthma Allergy Foundation (KAF), Department of Internal Medicine, Seoul National University, College of Medicine, 28 Yongon-dong, Chongno-Gu, 110-744 Seoul, Republic of Korea, email: [email protected] Professor Ali KOCABAS, Turkish Thoracic Society (TTS), Chief, Department of Respiratory Medicine, Cukurova University School of Medicine, 01330 Balcali, Adana, Turkey, email: [email protected] Dr ssa Giovanna LAURENDI, Direzione Generale della Prevenzione Sanitaria, Ufficio IX, Via della Civiltà Romana 7, 00144 Rome, Italy, email: [email protected] Dr Claude LENFANT, P.O. Box 83027, Gaithersburg, MD 20883-3027, United States of America, email: [email protected] Dr Carlos LUNA, Latin American Thoracic Association (ALAT), 11450 Buenos Aires, Argentina, email: [email protected]
23
Professor Sohei MAKINO, Dokkyo University School of Medicine, 880 Kita-kobayashi, Mibu Shimotsuga-gun, Tochigi 321-0293, Japan, email: [email protected] Mr Svein-Erik MYRSETH, European Federation of Allergy and Airways Diseases Patients’ Associations (EFA), EFA Central Office, Avenue Louise 327, 1050 Brussels, Belgium, email: [email protected] Professor Markku NIEMINEN, Finnish Lung Health Association, Sibeliuksenkatu 11A Tampere, 00250 Helsinki, Finland, email: [email protected] Professor Ruby PAWANKAR, Asian Allergy & Asthma Foundation, Nippon Medical School, Dept of Otolaryngology, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan, email: [email protected] Professor Klaus RABE, Department of Pulmonology, Leiden University Medical Center, Leiden, Netherlands, email: [email protected] Dr José ROSADO PINTO, Head of Immunoallergy Department, Hospital Dona Estefania, Serviço de Immunoalergologia, Rua Jacinta Marto 1169-045, Lisbon, Portugal, email: [email protected] Mr Archie TURNBULL, Forum of International Respiratory Societies, European Respiratory Society, 4, avenue Ste-Luce, CH-1003 Lausanne, Switzerland, email: [email protected] Dr Erkka VALOVIRTA, Turku Allergy Center, Kotkankatu 2, FIN-20610 Turku, Finland, email: [email protected] Professor Paul VAN CAUWENBERGE, University Hospital of Ghent, Dept of Oto-Rhino-Laryngology, De Pintelaan 185, B-9000 Ghent, Belgium, email: [email protected] Professor Chris VAN WEEL, World Organization of Family Doctors (WONCA), HAG-229, Postbox 9101, 6500 HB-Nijemegen, Netherlands, email: [email protected] Dr Giovanni VIEGI, CNR Istituto di Fisiologia Clinica, Via Trieste 41, I-56126 Pisa, Italy, email: [email protected] Professor Ulrich WAHN, European Academy of Allergology and Clinical Immunology (EAACI), Charité Hospital, Augustenburger Platz 1, D-13353 Berlin, Germany, email: [email protected] Professor Arzu YORGANCIOGLU, Turkish Thoracic Society (TTS), Celal University School of Medicine, Bayor, 45010 Manisa, Turkey, email: [email protected]
World Health Organization Dr Robert BEAGLEHOLE, Director, Department of Chronic Diseases and Health, Promotion (CHP), Noncommunicable Diseases and Mental Health, email: [email protected] Dr Leopold Joseph BLANC, Coordinator, Stop TB Department, email: [email protected] Dr Nikolai KHALTAEV (Secretary), Responsible Officer, Chronic Respiratory Diseases and Arthritis, Chronic Diseases Prevention and Management, (CHP/CPM/CRA), email: [email protected] Dr Eva MANTZOURANIS, Medical Officer, Chronic Respiratory Diseases and Arthritis, Chronic Diseases Prevention and Management, (CHP/CPM/CRA), email: [email protected] Dr Paolo Maria MATRICARDI (Co-Rapporteur), Research Officer, Chronic Respiratory Diseases and Arthritis, Chronic Diseases Prevention and Management, (CHP/CPM/CRA), email: [email protected] Dr Salah-Eddine OTTMANI, Medical Officer, Stop TB Department, email: [email protected] Dr Bruce PFLEGER (Co-Rapporteur), Research Officer, Chronic Respiratory Diseases and Arthritis, Chronic Diseases Prevention and Management (CHP/CPM/CRA), email: [email protected] Dr Serge RESNIKOFF, Coordinator, Chronic Diseases Prevention and Management (CHP/CPM), email: [email protected] Mr Igor ROZOV, External Relations Officer, External Relations and Governing Bodies, Government, Civil Society and Private Sector Relations (EGB/GPR), email: [email protected]
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1Unable to attend: Professor Norbert Berend, Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, P.O. Box M77, Missenden
Road, NSW 2050, Australia, email: [email protected] Dr Nils Billo, International Union Against Tuberculosis and Lung Disease (IUATLD), 68, boulevard Saint-Michel, F-75006
Paris, France Dr Michael Blaiss, American College of Allergy, Asthma and Immunology (ACAAI), 85 West Algonquin Road, Suite 550,
Arlington Heights, IL 60005, United States of America, email: [email protected] Professor Giorgio Walter Canonica, University of Genoa, Allergy & Respiratory Diseases, Pad. Maragliano - L.go R. Benzi
10, I-16132 Genoa, Italy, email: [email protected] Professor Yoshinosuke Fukuchi, Dept of Respiratory Medicine, Juntendo University School of Medicine, 2-1-1 Hongo,
Bunkyo-ku, Tokyo, Japan, email: [email protected] Professor Takeshi Fukuda, Asia Pacific Association of Allergology and Clinical Immunology (APAACI), Dept of Pulmonary
Medicine, Dokkyo University School of Medicine, 880 Kita-kobayashi, Mibu-machi, Tochigi 321-0293, Japan, email: [email protected]
Professor Donato Greco, Centro Nazionale per il Controllo e la Prevenzione della Malattie (CCM), Ministero Della Salute, Via della Civiltà Romana 7, 00144 Rome, Italy, email: [email protected]
Dr Lawrence D. Grouse, International Coalition for Chronic Obstructive Pulmonary Disease (ICC), 8316 86th Ave. NW, Gig Harbor, WA 98332, United States of America, email: [email protected] (replaced by Dr Dmitry Nonikov, email: [email protected])
Professor Bruno Housset, Société de Pneumologie de Langue Française (SPLF), 66, boulevard Saint-Michel, F-75006 Paris, France, email: [email protected]
Dr Suzanne Hurd, P.O. Box 83027, Gaithersburg, MD 20883-3027, United States of America, email: [email protected] Dr James Kiley, Division of Lung Diseases, National Heart, Lung & Blood Institute (NHLBI), National Institute of Health,
DHHS, Rockledge Bldg. Room 10018, Bethesda, MD 20892-7952, United States of America, email: [email protected] Professor Paul O'Byrne, St. Joseph's Hospital, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada, email:
[email protected] Professor Pekka Puska, Director-General, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300
Helsinki, Finland, email: [email protected] Professor Estelle R. Simons, American Academy of Allergy, Asthma and Immunology (AAAAI), University of Manitoba -
Room AE101, 671 William Avenue, Winnipeg, MB R3E OZ2, Canada, email: [email protected] Professor Umberto Solimene, World Federation of Hydrotherapy and Climatotherapy, Via Cicognara, 7, I-20129 Milan,
Italy, email: [email protected].
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olog
ists
: A
MR
O a
nd p
ossi
bly
othe
r reg
ions
th
roug
h in
tern
atio
nal a
ffilia
te
mem
bers
hip
Am
eric
an T
hora
cic
Soc
iety
(A
TS).
Pre
side
nt:
Dr P
eter
D.
Wag
ner
(pdw
agne
r@uc
sd.e
du)
1905
Am
eric
an J
ourn
al o
f R
espi
rato
ry a
nd C
ritic
al C
are
Med
icin
e; A
mer
ican
Jou
rnal
of
Res
pira
tory
Cel
l and
Mol
ecul
ar
Bio
logy
; P
roce
edin
gs o
f the
A
mer
ican
Tho
raci
c S
ocie
ty
ww
w.th
orac
ic.o
rg
To p
reve
nt a
nd tr
eat r
espi
rato
ry d
isea
se th
roug
h re
sear
ch,
educ
atio
n, p
atie
nt c
are
and
advo
cacy
; to
decr
ease
mor
bidi
ty
and
mor
talit
y fro
m re
spira
tory
dis
orde
rs a
nd li
fe-th
reat
enin
g ac
ute
illne
sses
in p
eopl
e of
all
ages
, int
erac
ting
with
nat
iona
l an
d in
tern
atio
nal o
rgan
izat
ions
that
hav
e si
mila
r goa
ls.
Non
gove
rnm
enta
l, no
npro
fit, i
nter
natio
nal,
prof
essi
onal
and
sci
entif
ic
soci
ety
for r
espi
rato
ry a
nd
criti
cal-c
are
med
icin
e.
12 s
peci
aliz
ed a
ssem
blie
s13
000
glo
bally
: AFR
O, A
MR
O,
EM
RO
, EU
RO
, SE
AR
O, W
PR
O
Asi
an A
llerg
y an
d A
sthm
a Fo
unda
tion
(AA
AF)
. P
resi
dent
: Pro
fess
or R
uby
Paw
anka
r.
(Paw
anka
rRub
y<su
san@
nms.
ac.jp
)
2004
web
site
in p
repa
ratio
n
To a
dvan
ce e
xcel
lent
clin
ical
pra
ctic
e of
alle
rgic
dis
ease
s an
d to
redu
ce th
eir
burd
en th
roug
h ed
ucat
ion,
trai
ning
, res
earc
h,
cost
effe
ctiv
e tre
atm
ent a
nd p
ublic
aw
aren
ess
thro
ugh
cont
inuo
us d
ialo
gue
with
the
heal
th m
inis
try a
nd w
orld
or
gani
zatio
ns w
ith th
e sa
me
goal
s.
Reg
iona
l no
ngov
ernm
enta
l or
gani
zatio
n
50 m
embe
rs re
pres
entin
g al
l Asi
an
coun
tries
: S
EA
RO
, WP
RO
Asi
an P
acifi
c A
ssoc
iatio
n of
A
llerg
olog
y an
d C
linic
al
Imm
unol
ogy
(APA
AC
I).
Pre
side
nt:
Pro
f Tak
eshi
Fu
kuda
(t-
fuku
da@
dokk
yom
ed.a
c.jp
)
1989
ww
w.a
paac
i.org
To s
uppo
rt th
e de
velo
pmen
t of t
he d
isci
plin
e of
alle
rgy,
as
thm
a an
d cl
inic
al im
mun
olog
y in
the
regi
on; t
o en
cour
age
and
assi
st in
form
ing
natio
nal s
ocie
ties
whe
re n
one
exis
t; to
pr
omot
e th
e ex
chan
ge a
nd p
rogr
ess
of k
now
ledg
e in
the
regi
on; t
o st
udy
the
prev
entio
n an
d tre
atm
ent o
f alle
rgy,
as
thm
a an
d im
mun
e-m
edia
ted
dise
ases
spe
cific
to th
e re
gion
; to
pro
mot
e ex
chan
ges
in tr
aini
ng p
rogr
amm
es b
etw
een
mem
ber c
ount
ries;
to h
elp
coop
erat
ion
betw
een
clin
ical
and
ba
sic
rese
arch
; to
deve
lop
prog
ram
mes
for p
ublic
edu
catio
n;
to c
oope
rate
with
oth
er in
tern
atio
nal o
rgan
izat
ions
with
sim
ilar
goal
s; to
dis
sem
inat
e kn
owle
dge
thro
ugh
inte
rnat
iona
l co
ngre
sses
and
by
othe
r mea
ns.
Ass
ocia
tion
of n
atio
nal
soci
etie
s of
alle
rgy
and
clin
ical
imm
unol
ogy
in th
e A
sia-
Pac
ific
regi
on
15 n
atio
nal s
ocie
ties
in S
EA
RO
, W
PR
O
Asi
an P
acifi
c S
ocie
ty o
f R
espi
rolo
gy (A
PSR
).
Pre
side
nt:
Pro
fess
or Y
. Fu
kuch
i (y
fuku
chi@
med
.junt
endo
.ac.
jp)
1985
Res
piro
logy
w
ww
.aps
resp
.org
To a
dvan
ce a
nd p
rom
ote
know
ledg
e of
the
resp
irato
ry s
yste
m
in h
ealth
and
dis
ease
; to
striv
e to
enc
oura
ge re
sear
ch a
nd
impr
ove
clin
ical
pra
ctic
e th
roug
h te
achi
ng; t
o in
crea
se
awar
enes
s of
hea
lth p
robl
ems
in th
e ar
ea a
nd to
pro
mot
e ex
chan
ge o
f kno
wle
dge
amon
g re
spiro
logi
sts
in th
e A
sia-
Pac
ific
regi
on.
Reg
iona
l no
ngov
ernm
enta
l or
gani
zatio
n10
,150
: SE
AR
O, W
PR
O
Ann
ex: G
AR
D P
artic
ipan
ts a
s of
May
200
5
Nam
e of
Org
aniz
atio
nY
ear
esta
blis
hed
Jour
nal a
nd W
ebsi
te a
ddre
ssM
issi
onC
ateg
ory
(Int.O
rg./N
GO
/etc
.)In
tere
st s
ectio
ns o
r ass
embl
ies
No.
of m
embe
rs/p
artn
ers
and
repr
esen
tatio
n by
WH
O R
egio
n
Dan
ish
Lung
Hea
lth
Ass
ocia
tion
(DLA
). P
resi
dent
: C
harlo
tte F
ugls
ang
(Cha
rlotte
.Fug
lsan
g@lu
nge.
dk)
1901
ww
w.lu
ngef
oren
ing.
dkTo
impr
ove
prev
entio
n an
d tre
atm
ent o
f lun
g di
seas
es in
D
enm
ark
and
to h
elp
patie
nts
with
thes
e di
seas
es (e
spec
ially
ch
roni
c ob
stru
ctiv
e pu
lmon
ary
dise
ase)
in
this
cou
ntry
.
Nat
iona
l no
ngov
ernm
enta
l or
gani
zatio
n
3493
mem
bers
from
the
Faro
e Is
land
s an
d G
reen
land
: EU
RO
Dok
kyo
Uni
vers
ity S
choo
l of
Med
icin
e, W
HO
Col
labo
ratin
g C
entre
for P
reve
ntio
n an
d C
ontro
l of C
hron
ic R
espi
rato
ry
Dis
ease
s, J
apan
. H
ead:
P
rofe
ssor
S. M
akin
o (s
-m
akin
o@do
kkyo
med
.ac.
jp)
Term
s of
refe
renc
e as
WH
O C
olla
bora
ting
Cen
tre; A
sia-
Pac
ific
Initi
ativ
e fo
r Chr
onic
Res
pira
tory
Dis
ease
s.
WH
O C
olla
bora
ting
Cen
treS
EA
RO
, WP
RO
Eur
opea
n A
cade
my
of A
llerg
y an
d C
linic
al Im
mun
olog
y (E
AA
CI).
Pre
side
nt: P
rofe
ssor
A
ntho
ny J
. Fre
w
(ajf@
eaac
i.org
)
1956
Alle
rgy
(Eur
opea
n Jo
urna
l of
Alle
rgy
and
Clin
ical
Im
mun
olog
y) w
ww
.eaa
ci.n
et
To p
rom
ote
basi
c an
d cl
inic
al re
sear
ch; a
sses
s an
d di
ssem
inat
e sc
ient
ific
info
rmat
ion;
func
tion
as a
refe
renc
e bo
dy fo
r oth
er s
cien
tific
, hea
lth a
nd p
oliti
cal o
rgan
izat
ions
; en
cour
age
and
prov
ide
train
ing
and
cont
inui
ng e
duca
tion;
pr
omot
e go
od p
atie
nt c
are
for a
llerg
ic a
nd im
mun
olog
ical
di
seas
es.
Non
gove
rnm
enta
l, no
npro
fit o
rgan
izat
ion
for
acad
emic
ians
, res
earc
h in
vest
igat
ors
and
clin
icia
ns
Sec
tions
for a
sthm
a, d
erm
atol
ogy,
ot
orhi
nola
ryng
olog
y, im
mun
olog
y an
d pa
edia
trics
to im
prov
e in
form
atio
n ex
chan
ge a
nd
colla
bora
tion
betw
een
scie
ntis
ts
with
in a
nd o
utsi
de E
AA
CI.
Sec
tions
can
pro
pose
task
forc
es
and
join
t ses
sion
s w
ith o
ther
sp
ecia
list s
ocie
ties.
39 E
urop
ean
natio
nal s
ocie
ties,
ov
er 3
500
mem
bers
: E
UR
O
Eur
opea
n C
entre
for A
llerg
y R
esea
rch
Foun
datio
n (E
CA
RF)
. H
ead:
Pro
fess
or
Dr.
med
. Tor
sten
Zub
erbi
er
(eca
rf@ch
arite
.de)
2003
ww
w.e
carf.
org
To im
prov
e kn
owle
dge,
rese
arch
and
aw
aren
ess
of a
llerg
ies;
de
crea
se th
e bu
rden
of d
isea
se in
pat
ient
s an
d in
soc
iety
th
roug
h st
ruct
ural
rese
arch
in a
llerg
y, s
prea
ding
of e
xcel
lenc
e an
d kn
owle
dge
amon
g ph
ysic
ians
and
the
publ
ic, i
nitia
tives
for
impr
ovin
g pa
tient
car
e, a
ctiv
ities
for a
bet
ter q
ualit
y of
life
for
alle
rgic
pat
ient
s.
Non
gove
rnm
enta
l fo
unda
tion
Col
labo
ratio
n w
ith A
llerg
y C
entre
C
harit
é, s
peci
aliz
ed in
clin
ical
w
ork,
rese
arch
and
dis
sem
inat
ion
of k
now
ledg
e in
alle
rgy:
E
UR
O
Eur
opea
n Fe
dera
tion
of A
llerg
yan
d A
irway
s D
isea
ses
Pat
ient
s' A
ssoc
iatio
ns (E
FA).
P
resi
dent
: Sve
in-E
rik M
yrse
th
(EFA
Offi
ce@
skyn
et.b
e)
1992
ww
w.e
fane
t.org
To im
prov
e th
e qu
ality
of l
ife o
f peo
ple
with
ast
hma,
chr
onic
ob
stru
ctiv
e pu
lmon
ary
dise
ase
and
alle
rgy
and
of th
eir c
arer
s th
roug
hout
Eur
ope,
con
tribu
ting
to a
Eur
opea
n co
mm
unity
tha t
shar
es th
e re
spon
sibi
lity
for s
ubst
antia
lly re
duci
ng th
e fre
quen
cy a
nd s
ever
ity o
f the
se c
ondi
tions
and
reco
gniz
es th
e so
cial
, env
ironm
enta
l, ec
onom
ic a
nd h
ealth
impl
icat
ions
.
Foun
datio
n A
llian
ce o
f 41
orga
niza
tions
in 2
3 co
untri
es in
Eur
ope
repr
esen
ting
250
000
pers
ons:
EU
RO
Eur
opea
n R
espi
rato
ry S
ocie
ty
(ER
S).
Pre
side
nt: D
r Gio
vann
i V
iegi
(vi
egig
@ifc
.cnr
.it)
1990
Eur
opea
n R
espi
rato
ry J
ourn
al,
Eur
opea
n R
espi
rato
ry
Mon
ogra
ph,
Eur
opea
n R
espi
rato
ry R
evie
w,
Eur
opea
n R
espi
rato
ry T
opic
,E
RS
New
slet
ter,
Bre
athe
w
ww
.ers
net.o
rg
Pro
mot
ing
rese
arch
; fos
terin
g ed
ucat
ion;
exc
hang
ing
know
ledg
e; im
prov
ing
patie
nt c
are.
Non
gove
rnm
enta
l, no
npro
fit in
tern
atio
nal
med
ical
org
aniz
atio
n
10 s
cien
tific
ass
embl
ies
serv
e as
fo
rum
to p
rese
nt a
nd d
iscu
ss
scie
ntifi
c w
ork
at y
early
con
gres
s
Ove
r 700
0 m
embe
rs in
100
co
untri
es:
AFR
O, A
MR
O, E
MR
O,
EU
RO
, SE
AR
O, W
PR
O
Finn
ish
Lung
Hea
lth
Ass
ocia
tion
(FIL
HA
). P
resi
dent
: Pro
fess
or M
arkk
u M
. Nie
min
en
(mni
emin
en@
tays
.fi o
r m
arkk
u.ni
emin
en@
filha
)
1907
ww
w.fi
lha.
fi
Trai
ning
and
edu
catio
n of
man
agem
ent o
f chr
onic
resp
irato
ry
dise
ases
; des
ign,
impl
emen
tatio
n of
nat
iona
l pro
gram
mes
for
dise
ases
(ast
hma,
chr
onic
obs
truct
ive
pulm
onar
y di
seas
e,
slee
p ap
noea
), fo
r sm
okin
g ce
ssat
ion
(sin
ce 1
994)
and
im
plem
enta
tion
of in
tern
atio
nal p
roje
ct (t
uber
culo
sis)
; re
sear
ch, e
xper
t net
wor
king
and
hum
an re
sour
ce
deve
lopm
ent.
Nat
iona
l no
ngov
ernm
enta
l or
gani
zatio
n W
HO
col
labo
ratin
g ce
ntre
EU
RO
(Fin
land
, Rus
sian
Fe
dera
tion,
Bal
tic n
atio
ns),
SE
AR
O (K
yrgy
zsta
n, M
ongo
lia),
WP
RO
(Chi
na)
Foru
m o
f Int
erna
tiona
l R
espi
rato
ry S
ocie
ties
(FIR
S).
Exe
cutiv
e S
ecre
tary
: Arc
hie
Turn
bull
(a
rchi
e.tu
rnbu
ll@er
snet
.org
)
2002
Adv
ocac
y fo
r glo
bal r
espi
rato
ry h
ealth
and
iden
tific
atio
n of
ne
w a
reas
for g
loba
l ini
tiativ
es. A
ims
to b
e at
tain
ed b
y th
e co
nsid
erat
ion
of n
eeds
and
the
prop
osal
of r
elat
ed p
roje
cts,
im
plem
ente
d jo
intly
or i
ndiv
idua
lly b
y th
e m
embe
r or
gani
zatio
ns.
Coo
pera
tive
unio
n of
in
tern
atio
nal p
rofe
ssio
nal
and
scie
ntifi
c so
ciet
ies
Par
ticip
atin
g or
gani
zatio
ns in
clud
e A
CC
P, A
LAT,
AP
SR
, ATS
, ER
S,
UN
ION
and
ULA
STE
R.
Nam
e of
Org
aniz
atio
nY
ear
esta
blis
hed
Jour
nal a
nd W
ebsi
te a
ddre
ssM
issi
onC
ateg
ory
(Int.O
rg./N
GO
/etc
.)In
tere
st s
ectio
ns o
r ass
embl
ies
No.
of m
embe
rs/p
artn
ers
and
repr
esen
tatio
n by
WH
O R
egio
n
Glo
bal A
llerg
y an
d A
sthm
a E
urop
ean
Net
wor
k (G
A2L
EN).
Cha
irman
: Pro
fess
or P
aul V
an
Cau
wen
berg
e (P
aul.V
anca
uwen
berg
e@ru
g.a
c.be
or
paul
.van
cauw
enbe
rge@
UG
ent
.be)
2004
ww
w.g
a2le
n.ne
t
To e
stab
lish
an in
tern
atio
nally
com
petit
ive
netw
ork;
to
enha
nce
qual
ity a
nd re
leva
nce
of re
sear
ch a
nd a
ddre
ss a
ll as
pect
s of
the
dise
ase;
to
decr
ease
the
burd
en o
f alle
rgy
and
asth
ma
thro
ugho
ut E
urop
e. A
ctiv
ities
con
sist
of i
nteg
ratio
n,
coor
dina
tion
of s
cien
tific
act
iviti
es a
nd s
prea
ding
exc
elle
nce.
Res
earc
h ne
twor
k in
al
lerg
y an
d as
thm
a
Wor
k pa
ckag
es in
clud
e: n
utrit
ion,
in
fect
ion,
env
ironm
ent a
nd
pollu
tion,
occ
upat
ion,
gen
der
sens
itiza
tion
and
alle
rgic
dis
ease
, ai
rway
rem
odel
ling,
clin
ical
car
e,
gene
tics
and
geno
mic
s
26 le
adin
g E
urop
ean
team
s,
EA
AC
I and
EFA
, one
or m
ore
cent
res
in e
ach
Eur
opea
n co
untry
: E
UR
O
Glo
bal I
nitia
tive
for A
sthm
a (G
INA
). C
hair
of E
xecu
tive
Com
mitt
ee: P
rofe
ssor
Pau
l O'
Byr
ne
(oby
rnep
@fh
s.m
cmas
ter.c
a),
Cha
ir of
Sci
entif
ic C
omm
ittee
: S
uzan
ne H
urd
(shu
rd@
prod
igy.
net)
1991
ww
w.g
inas
thm
a.co
m
Wor
ks w
ith h
ealth
car
e pr
ofes
sion
als
and
publ
ic h
ealth
of
ficia
ls a
roun
d th
e w
orld
to re
duce
ast
hma
prev
alen
ce,
mor
bidi
ty a
nd m
orta
lity.
Thr
ough
evi
denc
e-ba
sed
guid
elin
es
for a
sthm
a m
anag
emen
t, an
d ev
ents
suc
h as
the
annu
al
cele
brat
ion
of W
orld
Ast
hma
Day
, the
Glo
bal I
nitia
tive
for
Ast
hma
wor
ks to
impr
ove
the
lives
of p
eopl
e w
ith a
sthm
a in
ev
ery
corn
er o
f the
glo
be.
Pro
gram
me
laun
ched
in
colla
bora
tion
with
WH
O
and
Nat
iona
l Ins
titut
es o
f H
ealth
/Nat
iona
l Hea
rt,
Lung
and
Blo
od In
stitu
te
Exe
cutiv
e, S
cien
ce a
nd
Dis
sem
inat
ion
Com
mitt
ees;
na
tiona
l lau
nch
lead
ers
AFR
O, A
MR
O, E
MR
O, E
UR
O,
SE
AR
O, W
PR
O (G
AR
D ta
rget
co
untri
es: A
rgen
tina,
Bra
zil,
Cos
ta
Ric
a, P
ortu
gal,
Geo
rgia
, Rus
sian
Fe
dera
tion,
Syr
ian
Ara
b R
epub
lic,
Vie
tnam
)
Glo
bal I
nitia
tive
for C
hron
ic
Obs
truct
ive
Lung
Dis
ease
(G
OLD
). C
hair
of E
xecu
tive
Com
mitt
ee: D
r A. S
onia
Bui
st
(bui
st@
ohsu
.edu
), C
hair
of
Sci
entif
ic C
omm
ittee
: Suz
anne
H
urd
(shu
rd@
prod
igy.
net)
1998
ww
w.g
oldc
opd.
com
Incr
ease
aw
aren
ess
of m
edic
al c
omm
unity
, pub
lic h
ealth
of
ficia
ls a
nd g
ener
al p
ublic
that
chr
onic
obs
truct
ive
pulm
onar
y di
seas
e is
a p
ublic
hea
lth p
robl
em; d
ecre
ase
its m
orbi
dity
and
m
orta
lity
thro
ugh
impl
emen
ting
effe
ctiv
e pr
ogra
mm
es fo
r its
di
agno
sis,
man
agem
ent a
nd p
reve
ntio
n st
rate
gies
for u
se in
al
l cou
ntrie
s an
d pr
omot
ing
stud
ies
into
the
etio
logy
of i
ts
incr
easi
ng p
reva
lenc
e.
Pro
gram
me
laun
ched
in
colla
bora
tion
with
WH
O
and
Nat
iona
l Ins
titut
es o
f H
ealth
/Nat
iona
l Hea
rt,
Lung
and
Blo
od In
stitu
te
Exe
cutiv
e, S
cien
ce a
nd
Dis
sem
inat
ion
Com
mitt
ees.
N
atio
nal L
aunc
h Le
ader
sA
MR
O, E
UR
O
Ghe
nt U
nive
rsity
, WH
O
Col
labo
ratin
g C
entre
(GU
-W
CC
) Dep
t. R
espi
rato
ry
Dis
ease
s. D
irect
or: P
rofe
ssor
G
uy J
oos
(Guy
.Joo
s@U
Gen
t.be)
1817
ww
w.u
gent
.be
To o
ffer h
igh-
qual
ity, r
esea
rch-
base
d ed
ucat
ion;
to p
lay
an
impo
rtant
role
in fu
ndam
enta
l and
app
lied
rese
arch
; to
be a
n op
en, p
lura
listic
, int
erna
tiona
l ins
titut
e w
ith a
soc
ial
resp
onsi
bilit
y (fu
ll m
issi
on s
tate
men
t: w
ww
.uge
nt.b
e/en
/ghe
ntun
iv/m
anag
emen
t/mis
sion
).
WH
O C
olla
bora
ting
Cen
treE
UR
O
Istit
uto
di R
icov
ero
e C
ura
e C
arat
tere
Sci
entif
ico
(IRC
CS)
S
cien
tific
Dire
ctor
: Pro
fess
or
Ser
gio
Bon
ini
(ser
gio.
boni
ni@
sanr
affa
ele.
it)
No
info
rmat
ion
avai
labl
e.
Inst
itute
of N
euro
biol
ogy
and
Mol
ecul
ar M
edic
ine
Nat
iona
l R
esea
rch
Cou
ncil
(CN
R)
Hea
d: D
r Gui
do R
asi
(gui
do.ra
si@
arto
v.in
mm
.cnr
.it)
No
info
rmat
ion
avai
labl
e.
Inte
rdis
cipl
inar
y A
ssoc
iatio
n fo
r R
esea
rch
in L
ung
Dis
ease
(A
IMA
R). P
resi
dent
: Dr
Cla
udio
F. D
onne
r (s
egre
teria
@ai
mar
netw
ork.
org)
2001
Mul
tidis
cipl
inar
y R
espi
rato
ry
Med
icin
e w
ww
.aim
arne
twor
k.or
g
To p
reve
nt lu
ng d
isea
se a
nd p
rom
ote
lung
hea
lth; t
o im
prov
e th
e qu
ality
of p
atie
nt c
are
by e
duca
ting
phys
icia
ns a
nd a
llied
pr
ofes
sion
als
and
prov
idin
g th
em w
ith p
rogr
amm
es a
nd
stra
tegi
es fo
r fig
htin
g lu
ng d
isea
se s
uch
as a
sthm
a, c
hron
ic
obst
ruct
ive
pulm
onar
y di
seas
e, in
fect
ions
, to
bacc
o an
d en
viro
nmen
tal p
ollu
tion;
to p
rom
ote
rese
arch
on
lung
dis
ease
; to
incr
ease
the
awar
enes
s of
pub
lic a
bout
lung
dis
ease
s an
d th
eir r
isks
; to
invo
lve
all d
ecis
ion-
mak
ers
in c
ampa
igns
to
redu
ce e
nviro
nmen
tal a
nd to
bacc
o po
llutio
n. T
o pr
omot
e an
d m
aint
ain
links
with
all
soc
ietie
s an
d ag
enci
es in
tere
sted
in
lung
hea
lth, i
nclu
ding
pat
ient
s' o
rgan
izat
ions
, esp
ecia
lly in
the
Med
iterr
anea
n ar
ea.
Non
prof
it in
terd
isci
plin
ary
asso
ciat
ion
for r
esea
rch
in lu
ng d
isea
se
Med
ical
are
as in
volv
ed :
envi
ronm
enta
l, ge
nera
l, in
tern
al
and
occu
patio
nal m
edic
ine,
in
tens
ive
care
, car
diol
ogy,
thor
acic
su
rger
y, ra
diol
ogy,
end
ocrin
olog
y,
epid
emio
logy
, pha
rmac
olog
y,
gast
roen
tero
logy
, ger
iatri
cs,
imm
unol
ogy,
infe
ctio
us d
isea
ses,
m
icro
biol
ogy,
neu
rolo
gy, o
ncol
ogy,
ot
olar
yngo
logy
, pae
diat
rics,
pn
eum
olog
y
EU
RO
Nam
e of
Org
aniz
atio
nY
ear
esta
blis
hed
Jour
nal a
nd W
ebsi
te a
ddre
ssM
issi
onC
ateg
ory
(Int.O
rg./N
GO
/etc
.)In
tere
st s
ectio
ns o
r ass
embl
ies
No.
of m
embe
rs/p
artn
ers
and
repr
esen
tatio
n by
WH
O R
egio
n
Inte
rnat
iona
l Ass
ocia
tion
of
Ast
hmol
ogy
(INTE
RA
SMA
).
Pre
side
nt: H
ugo
E. N
effe
n (h
enef
fen@
info
via.
com
.ar)
1954
Jour
nal o
f Inv
estig
atio
nal
Alle
rgol
ogy
& C
linic
al
Imm
unol
ogy,
Int
eras
ma
New
s ne
wsl
ette
r w
ww
.inte
rasm
a.or
g
A fo
rum
for i
nter
disc
iplin
ary
disc
ussi
ons
amon
g
pneu
mol
ogis
ts, a
llerg
ists
, pae
diat
ricia
ns a
nd g
ener
al
prac
titio
ners
to
exch
ange
info
rmat
ion
on a
sthm
a re
sear
ch,
prac
tice
and
man
agem
ent:
to fo
cus
on a
ll as
pect
s of
ast
hma,
br
idgi
ng th
e ga
p be
twee
n re
sear
ch a
nd c
linic
al p
ract
ice;
to
enco
urag
e as
thm
a ed
ucat
ion
prog
ram
mes
for a
ll he
alth
car
e pr
ofes
sion
als,
edu
cato
rs a
nd a
dmin
istra
tors
; to
impr
ove
the
qual
ity o
f life
of a
sthm
atic
s; t
o de
crea
se th
e pr
eval
ence
, m
orbi
dity
and
mor
talit
y of
ast
hma.
Inte
rnat
iona
l no
ngov
ernm
enta
l or
gani
zatio
n
Exe
cutiv
e C
omm
ittee
, reg
iona
l ch
apte
rsA
MR
O, A
FRO
, EM
RO
, EU
RO
, W
PR
O
Inte
rnat
iona
l Chr
onic
O
bstru
ctiv
e P
ulm
onar
y D
isea
se C
oalit
ion
(ICC
). C
hair
of E
xecu
tive
Com
mitt
ee: L
arry
G
rous
e (lg
rous
e@em
ail.m
sn.c
om)
1999
ww
w.in
tern
atio
nalc
opd.
org
To im
prov
e ca
re o
f chr
onic
obs
truct
ive
pulm
onar
y di
seas
e pa
tient
s th
roug
h in
crea
sing
aw
aren
ess
of th
e di
seas
e an
d an
un
ders
tand
ing
of it
s di
agno
sis
and
man
agem
ent f
or b
oth
care
rs a
nd p
atie
nts.
To
crea
te a
llian
ces
with
pro
fess
iona
l gr
oups
to a
ccom
plis
h th
ese
ends
. To
enco
urag
e an
d su
ppor
t na
tiona
l and
regi
onal
gro
ups
in a
dvoc
acy
effo
rts to
war
d po
licy-
mak
ers
to p
riorit
ize
chro
nic
obst
ruct
ive
pulm
onar
y di
seas
e in
re
sear
ch a
nd c
are.
Non
prof
it co
rpor
atio
n;
outre
ach
of G
loba
l In
itiat
ive
for C
hron
ic
Obs
truct
ive
Lung
Dis
ease
an
d th
e U
nite
d S
tate
s C
hron
ic O
bstru
ctiv
e P
ulm
onar
y D
isea
se
Coa
litio
n
220
000
mem
bers
: AM
RO
, EM
RO
, E
UR
O, W
PR
O
Inte
rnat
iona
l Uni
on A
gain
st
Tube
rcul
osis
and
Lun
g D
isea
se (U
NIO
N). E
xecu
tive
Dire
ctor
: Dr N
ils B
illo
(nbi
llo@
iuat
ld.o
rg)
1956
Inte
rnat
iona
l Jou
rnal
of
Tube
rcul
osis
& L
ung
Dis
ease
w
ww
.iuat
ld.o
rg
To p
reve
nt a
nd c
ontro
l tub
ercu
losi
s an
d lu
ng d
isea
se,
parti
cula
rly in
low
-inco
me
coun
tries
. To
prom
ote
natio
nal
auto
nom
y, w
ithin
the
fram
ewor
k of
prio
ritie
s of
eac
h co
untry
, by
dev
elop
ing,
impl
emen
ting
and
asse
ssin
g an
titub
ercu
losi
s an
d re
spira
tory
hea
lth p
rogr
amm
es. T
o di
ssem
inat
e kn
owle
dge
on tu
berc
ulos
is, l
ung
dise
ase,
HIV
and
resu
lting
co
mm
unity
hea
lth p
robl
ems
in o
rder
to a
lert
doct
ors,
dec
isio
n-m
aker
s, o
pini
on-le
ader
s an
d th
e ge
nera
l pub
lic to
the
dise
ases
' rel
ated
dan
gers
. To
coo
rdin
ate,
ass
ist a
nd p
rom
ote
the
wor
k of
its
cons
titue
nt m
embe
rs th
roug
hout
the
wor
ld. T
o es
tabl
ish
and
mai
ntai
n cl
ose
links
with
WH
O, o
ther
Uni
ted
Nat
ions
org
aniz
atio
ns, g
over
nmen
tal
and
nong
over
nmen
tal
inst
itutio
ns in
hea
lth a
nd d
evel
opm
ent s
ecto
rs.
Mem
bers
hip
orga
niza
tion
with
par
tner
s in
all
regi
ons
of th
e w
orld
Sci
entif
ic g
roup
s in
ast
hma,
tu
berc
ulos
is, t
obac
co p
reve
ntio
n,
nurs
ing,
chi
ld lu
ng h
ealth
Par
tner
s in
clud
e W
HO
tu
berc
ulos
is p
rogr
amm
e; S
top
TB
Initi
ativ
e;
Glo
bal F
und
to F
ight
A
IDS
, Tub
ercu
losi
s an
d M
alar
ia;
Cen
ters
for D
isea
se C
ontro
l and
P
reve
ntio
n: A
FRO
Kor
ea A
sthm
a A
llerg
y Fo
unda
tion
(KA
AF)
. Pre
side
nt:
Pro
fess
or K
im Y
ou Y
oung
(y
ouyo
ung@
plaz
a.sn
u.ac
.kr)
2003
No
info
rmat
ion
avai
labl
e.N
atio
nal
nong
over
nmen
tal
orga
niza
tion
286
mem
bers
focu
sing
on
resp
irato
ry m
edic
ine
and
alle
rgy,
R
epub
lic o
f Kor
ea
Latin
Am
eric
an T
hora
cic
Soc
iety
(ALA
T). P
resi
dent
: Dr
Car
los
M L
una
(c
ymlu
na@
adva
nced
sl.c
om.a
r)
1996
ww
w.a
lato
rax.
com
To re
cord
and
dis
sem
inat
e sc
ient
ific
info
rmat
ion
abou
t lun
g di
seas
es; t
o te
ach;
to p
rom
ote
rese
arch
on
thor
acic
dis
ease
s in
Lat
in A
mer
ica;
to s
timul
ate
scie
ntifi
c co
ntac
t bet
wee
n th
e so
ciet
y's
mem
bers
and
oth
er n
atio
nal a
nd in
tern
atio
nal
resp
irato
ry s
ocie
ties;
to d
evel
op g
uide
lines
for t
he
man
agem
ent o
f tho
raci
c di
seas
es; t
o de
velo
p sc
ient
ific
depa
rtmen
ts in
side
the
asso
ciat
ion;
to e
dit s
cien
tific
pu
blic
atio
ns.
Non
gove
rnm
enta
l or
gani
zatio
n
Ast
hma,
chr
onic
obs
truct
ive
pulm
onar
y di
seas
e, c
ritic
al
pulm
onol
ogy,
end
osco
py,
inte
rstit
ial l
ung
dise
ases
, lu
ng in
fect
ions
, tho
raci
c su
rger
y,
paed
iatri
c pu
lmon
olog
y, p
ulm
onar
y ci
rcul
atio
n, re
spira
tory
pa
thop
hysi
olog
y, tu
berc
ulos
is
5700
: A
MR
O,
EU
RO
Nat
iona
l Pub
lic H
ealth
In
stitu
te, F
inla
nd (
KTL
).
Dire
ctor
: Pek
ka P
uska
(p
ekka
.pus
ka@
ktl.f
i)
1911
ww
w.k
tl.fi/
porta
l/eng
lish
To p
rom
ote
peop
le's
pos
sibi
lity
of li
ving
hea
lthy
lives
. In
tern
atio
nal c
olla
bora
tion
(e.g
. mul
tilat
eral
mon
itorin
g of
tre
nds
and
dete
rmin
ants
in c
ardi
ovas
cula
r dis
ease
s (M
ON
ICA
) pro
ject
).
Gov
ernm
enta
l ins
titut
e (u
nder
the
Min
istry
of
Soc
ial A
ffairs
and
Hea
lth),
WH
O C
olla
bora
ting
Cen
tre
Fin
land
: EU
RO
Nat
iona
l Hea
rt, L
ung
and
Blo
od In
stitu
te (N
HB
LI),
Div
isio
n of
Lun
g D
isea
ses.
D
irect
or: D
r Jam
es K
iley
(kile
yj@
nih.
gov)
ww
w.n
hlbi
.nih
.gov
Pro
gram
me
on a
sthm
a an
d ch
roni
c ob
stru
ctiv
e pu
lmon
ary
dise
ases
incl
udes
goa
ls o
n ep
idem
iolo
gy, r
esea
rch,
gen
etic
s an
d ph
arm
acog
enet
ics,
clin
ical
tria
ls, d
emon
stra
tion
and
educ
atio
n in
itiat
ives
.
Gov
ernm
enta
l or
gani
zatio
n
Act
ive
partn
er w
ith G
loba
l Ini
tiativ
e fo
r Chr
onic
Obs
truct
ive
Lung
D
isea
se a
nd w
ith W
HO
: A
FRO
, A
MR
O, E
MR
O, E
UR
O, S
EA
RO
, W
PR
O
Nam
e of
Org
aniz
atio
nY
ear
esta
blis
hed
Jour
nal a
nd W
ebsi
te a
ddre
ssM
issi
onC
ateg
ory
(Int.O
rg./N
GO
/etc
.)In
tere
st s
ectio
ns o
r ass
embl
ies
No.
of m
embe
rs/p
artn
ers
and
repr
esen
tatio
n by
WH
O R
egio
n
Por
tugu
ese
Soc
iety
of
Alle
rgol
ogy
and
Clin
ical
Im
mun
olog
y (S
PAIC
). P
resi
dent
: Mar
io M
orai
s de
A
lmei
da (s
paic
@sa
po.p
t)
1950
Rev
ista
Por
tugu
esa
de
Imun
oale
rgol
ogia
w
ww
.spa
ic.p
t
To p
reve
nt a
nd tr
eat a
llerg
ic d
isea
ses
thro
ugh
rese
arch
, ed
ucat
ion,
pat
ient
car
e an
d ad
voca
cy. T
o de
crea
se m
orbi
dity
an
d m
orta
lity
from
alle
rgic
and
resp
irato
ry d
isor
ders
, inc
ludi
ng
asth
ma,
in p
eopl
e of
all
ages
, int
erac
ting
with
nat
iona
l and
in
tern
atio
nal o
rgan
izat
ions
that
hav
e si
mila
r goa
ls.
Non
prof
it,
nong
over
nmen
tal,
natio
nal,
prof
essi
onal
and
sc
ient
ific
soci
ety
for
alle
rgic
and
resp
irato
ry
care
med
icin
e
12 s
peci
aliz
ed in
tere
st s
ectio
ns:
aero
biol
ogy,
alle
rgy
and
asth
ma
in
spor
ts, a
sthm
a, d
rug
alle
rgy,
ep
idem
iolo
gy, f
ood
alle
rgy,
im
mun
othe
rapy
, ins
ect v
enom
al
lerg
y, la
tex
alle
rgy,
prim
ary
imm
unod
efic
ienc
y, s
kin
alle
rgy,
rh
initi
s
355
activ
e m
embe
rs: E
UR
O
Rus
sian
Soc
iety
of
Pul
mon
olog
ists
(RSP
).
Pre
side
nt:
Pro
fess
or
Ale
xand
er G
Chu
chal
in
(Chu
chal
in@
inbo
x.ru
)
No
info
rmat
ion
avai
labl
e.
Res
pira
tory
Soc
iety
of F
renc
h S
peak
ing
coun
tries
(SPL
F).
Pre
side
nt-E
lect
: P
rofe
ssor
P
hilip
pe G
odar
d (p
resi
dent
-S
PLF
@sp
lf.or
g)
1916
Rev
ue d
es m
alad
ies
resp
irato
ires,
Info
-Res
pira
tion
ww
w.s
plf.o
rg
To p
rom
ote
all a
spec
ts o
f res
earc
h in
the
field
of l
ung
dise
ases
; to
educ
ate
heal
th p
rofe
ssio
nals
and
pat
ient
s in
or
der t
o in
crea
se q
ualit
y of
car
e an
d aw
aren
ess;
to
elab
orat
e pr
ogra
mm
es fo
r scr
eeni
ng, p
reve
ntio
n an
d tre
atm
ent o
f lun
g di
seas
es s
uch
as a
sthm
a, c
hron
ic o
bstru
ctiv
e pu
lmon
ary
dise
ase
and
occu
patio
nal d
isea
ses;
to in
tera
ct w
ith re
spira
tory
he
alth
offi
cial
s in
ord
er to
pro
duce
evi
denc
e-ba
sed
guid
elin
es.
Soc
iety
22 w
orki
ng g
roup
s in
volv
ed in
the
prep
arat
ion
and
cond
uct o
f a
year
ly c
ongr
ess
Ove
r 150
0 m
embe
rs fr
om v
ario
us
Fren
ch-s
peak
ing
coun
tries
(cen
tral
and
east
ern
Eur
ope,
Afri
can
and
Asi
an c
ount
ries)
: A
FRO
, EU
RO
, W
PR
O
Soc
iété
Fra
ncai
se
d'A
llerg
olog
ie e
t d'Im
mun
olog
ieC
liniq
ue (S
FAIC
). P
resi
dent
: P
rofe
ssor
Gab
rielle
Pau
li (G
abrie
lle.P
auli@
chru
-st
rasb
ourg
.fr)
No
info
rmat
ion
avai
labl
e.
Turk
ish
Thor
acic
Soc
iety
(T
TS).
Pre
side
nt:
Pro
fess
or H
aluk
Tur
ktas
(h
aluk
tur@
supe
ronl
ine.
com
)
1992
Turk
ish
Res
pira
tory
Jou
rnal
w
ww
.tora
ks.o
rg.tr
/eng
lish
To p
rovi
de th
e m
ost e
ffect
ive
scie
ntifi
c m
etho
ds fo
r pr
even
tion,
con
trol a
nd tr
eatm
ent o
f res
pira
tory
dis
ease
s, a
nd
to in
crea
se n
atio
nal r
espi
rato
ry h
ealth
thro
ugh
patie
nt c
are,
re
sear
ch, e
duca
tion
and
prom
otio
n of
nat
iona
l pol
icie
s.
Nat
iona
l, no
npro
fit
educ
atio
nal a
nd s
cien
tific
so
ciet
y14
sci
entif
ic w
orki
ng g
roup
s15
00 m
embe
rs, 1
5 br
anch
es
thro
ugho
ut T
urke
y: E
UR
O
Wor
ld A
llerg
y O
rgan
izat
ion
(WA
O).
Pre
side
nt: D
r Car
los
E. B
aena
-Cag
nani
(info
@w
orld
alle
rgy.
org)
1950
Jour
nal o
f Wor
ld A
llerg
y O
rgan
izat
ion,
Inte
rnat
iona
l A
rchi
ves
of A
llerg
y &
Im
mun
olog
y
ww
w.w
orld
alle
rgy.
org
To b
uild
a g
loba
l alli
ance
of a
llerg
y so
ciet
ies
to a
dvan
ce
exce
llenc
e in
clin
ical
car
e, re
sear
ch, e
duca
tion
and
train
ing.
Wor
ldw
ide
nong
over
nmen
tal
orga
niza
tion;
mem
ber o
f C
ounc
il fo
r Int
erna
tiona
l O
rgan
izat
ions
of M
edic
al
Sci
ence
s; w
orki
ng
rela
tions
hip
with
WH
O
Fede
ratio
n of
70
natio
nal,
regi
onal
an
d af
filia
te o
rgan
izat
ions
Tota
l ind
ivid
ual m
embe
rshi
p of
m
embe
r soc
ietie
s ov
er 3
8 00
0,
repr
esen
ting
92 c
ount
ries:
AFR
O,
AM
RO
, EM
RO
, EU
RO
, SE
AR
O,
WP
RO
Wor
ld F
eder
atio
n of
H
ydro
ther
apy
and
Clim
atot
hera
py (F
EMTE
C).
Pre
side
nt: D
r N. S
toro
shen
ko
(kur
ort@
onlin
e.ru
), S
ecre
tary
-G
ener
al: P
rofe
ssor
U.
Sol
imen
e (u
mbe
rto.s
olim
ene@
unim
i.it)
1937
ww
w.fe
mte
conl
ine.
com
To e
xpla
in th
e m
edic
al s
pa w
orld
; to
prom
ote
it in
an
inte
rnat
iona
l con
text
am
ong
Sta
tes
and
gove
rnin
g bo
dies
; to
enco
urag
e in
tern
atio
nal c
oope
ratio
n be
twee
n sp
as; t
o ex
chan
ge s
tudi
es, r
esea
rch
and
prac
tices
in th
e fie
ld o
f hy
drot
hera
py; t
o pr
omot
e de
velo
pmen
t of m
edic
al s
pas
and
clim
atic
reso
rts a
mon
g m
embe
rs a
nd w
orld
wid
e.
Non
gove
rnm
enta
l or
gani
zatio
n in
offi
cial
re
latio
ns w
ith W
HO
sin
ce
1985
2 50
0 m
edic
al c
entre
s in
volv
ed in
ac
tiviti
es; o
nce
a ye
ar, g
ener
al
mee
ting
of E
xecu
tive
Boa
rd;
mee
ting
of th
e fo
ur p
erm
anen
t co
mm
ittee
s -
med
ical
, eco
nom
ic,
tech
nica
l and
soc
ial
35 m
embe
rs: t
herm
al a
nd m
edic
al
spa
asso
ciat
ions
, fed
erat
ions
and
or
gani
zatio
ns d
ealin
g w
ith s
pa
prob
lem
s fro
m v
ario
us c
ount
ries:
A
FRO
, AM
RO
, EM
RO
, EU
RO
, S
EA
RO
, WP
RO
Wor
ld O
rgan
izat
ion
of F
amily
D
octo
rs (W
ON
CA
). P
resi
dent
: P
rofe
ssor
Chr
is V
an W
eel
(c.v
anw
heel
@ha
g.um
nn.n
l)
1972
ww
w.g
loba
lfam
ilydo
ctor
.com
To im
prov
e th
e qu
ality
of l
ife o
f peo
ples
of t
he w
orld
thro
ugh
defin
ing
and
prom
otin
g its
val
ues;
by
mai
ntai
ning
hig
h st
anda
rds
of c
are
in g
ener
al p
ract
ice/
fam
ily m
edic
ine;
by
prom
otin
g pe
rson
al, c
ompr
ehen
sive
and
con
tinui
ng c
are
for
the
indi
vidu
al in
the
cont
ext o
f the
fam
ily; b
y su
ppor
ting
deve
lopm
ent o
f aca
dem
ic o
rgan
izat
ions
of g
ener
al
prac
titio
ners
/fam
ily p
hysi
cian
s; b
y pr
ovid
ing
educ
atio
n to
m
embe
rs; b
y pr
esen
ting
educ
atio
nal,
rese
arch
and
ser
vice
ac
tiviti
es o
f mem
bers
in o
ther
wor
ld m
edic
al a
nd h
ealth
or
gani
zatio
ns.
Non
gove
rnm
enta
l or
gani
zatio
n in
offi
cial
re
latio
ns w
ith W
HO
Gov
erni
ng c
ounc
il m
eets
eve
ry
thre
e ye
ars;
regi
onal
cou
ncils
in
each
regi
on; e
xecu
tive
com
mitt
ee
mee
ts a
nnua
lly
97 m
embe
r org
aniz
atio
ns in
79
coun
tries
, tot
al m
embe
rshi
p ov
er
200
000
gene
ral p
ract
ition
ers
and
fam
ily p
hysi
cian
s: A
FRO
, AM
RO
, E
MR
O, E
UR
O, S
EA
RO
, WP
RO