Progress Against Breast

Cancer

Progress Against Breast Cancer

1970–1979

Progress Against Breast Cancer

1970–19791971: More limited mastectomy proven effective for early-stage breast cancer

Progress Against Breast Cancer

1970–19791974: Doxorubicin active against advanced breast cancer

Progress Against Breast Cancer

1970–19791975: Adjuvant chemotherapy increases cure rates for early-stage breast cancer

Progress Against Breast Cancer

1970–19791977: Estrogen receptor status proven to predict risk of breast cancer recurrence

1977: Many women can opt for breast-conserving surgery

1977: Breakthrough drug, tamoxifen, receives initial FDA approval

Late 1970s: Growing use of mammography saves lives

Progress Against Breast Cancer

1980–1989

Progress Against Breast Cancer

1980–19891986: Tamoxifen reduces breast cancer recurrence

Progress Against Breast Cancer

1990–1999

Progress Against Breast Cancer

1990–1999Mid-1990s: BRCA1 and BRCA2 gene mutations linked to increased breast cancer risk

1994, 2008: Taxanes emerge as vital chemotherapy option for breast cancer

Progress Against Breast Cancer

1990–1999Mid-1990s: Bone-building drugs help reduce complications of breast cancer and its treatment

Progress Against Breast Cancer

1990–19991996: Sentinel lymph node biopsy introduced to assess breast cancer spread

Progress Against Breast Cancer

1990–19991998: Oral chemotherapy drug, capecitabine, approved for advanced breast cancer

1998: Drug therapy can reduce breast cancer risk in women at high risk

1998: Chemotherapy before surgery helps more women benefit from breast-conserving treatment

1998: First targeted anti-breast cancer drug, trastuzumab (Herceptin), has major impact on care

Progress Against Breast Cancer

2000–Present

Progress Against Breast Cancer

2000–Present2000: High-dose chemotherapy plus stem cell transplant does not improve breast cancer survival

2000: Breast cancer subtypes identified

Progress Against Breast Cancer

2000–Present2002–2004: Novel genetic tests help guide breast cancer therapy

Progress Against Breast Cancer

2000–Present2003: Higher density, shorter term chemotherapy improves breast cancer survival

Progress Against Breast Cancer

2000–Present2004: New class of drugs, aromatase inhibitors, introduced

2004: Adding new drug, gemcitabine, extends survival for some women with advanced breast cancer

2004: Docetaxel helps reduce breast cancer recurrence

Progress Against Breast Cancer

2000–Present2005: Low-fat diet and regular exercise may reduce risk of breast cancer recurrence

2005: Digital mammography more accurate than standard mammography in younger women

Progress Against Breast Cancer

2000–Present2006: Screening, treatment key to declining U.S. breast cancer mortality

2006: Tamoxifen and raloxifene equally effective for preventing invasive breast cancer

2006: Many breast cancer survivors experience fatigue

Progress Against Breast Cancer

2000–Present2007: Lapatinib approved for patients whose HER2-positive breast cancer no longer responds to trastuzumab

2007: MRI screening recommended for women at high risk of breast cancer

2007: Declining breast cancer incidence linked to lower use of hormone replacement therapy

2007: Shorter course of radiation therapy is as effective as less frequent radiation therapy for early-stage breast cancer

Progress Against Breast Cancer

2000–Present2007: First in new class of drugs approved for advanced breast cancer that resists other treatments

2008–2010: Bevacizumab (Avastin) approved for advanced breast cancer

Progress Against Breast Cancer

2000–Present2009: Preventive surgery confirmed to reduce breast and ovarian cancer risk in women with BRCA gene mutations

2009: Standard chemotherapy is an option for older women

2009: PARP inhibitors show promise for difficult-to-treat breast cancers

Progress Against Breast Cancer

2000–Present2010: Targeted drug denosumumab helps prevent common bone-related complications in advanced breast cancer

2010: Removing fewer lymph nodes for some breast cancer patients does not impair survival

2010: New chemotherapy drug improves survival for advanced breast cancer

2011: Aromatase inhibitors cut breast cancer risk among women at high risk

Progress Against Breast Cancer

2000–Present2012: Two targeted drugs together are more potent than one for HER-2 positive breast cancer

2012-2013: “Armed-antibody” drug improves survival for women with resistant HER2 positive cancers

Progress Against Breast Cancer

Five-Year Survival

71

76

81

86

91

1975

1977

1979

1981

1983

1985

1987

1989

1991

1993

1995

1997

1999

2001

2003

2005

2007

2009

Year of Diagnosis

% o

f Pa

tien

ts S

urv

ivin

g F

ive

Ye

ars

Source: National Cancer Institute

Progress Against Breast Cancer

Mortality

20

22

24

26

28

30

32

34

36

1970

1972

1974

1976

1978

1980

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

Year of Death

Ca

nce

r D

ea

ths

pe

r 1

00

,00

0 P

eo

ple

Source: National Cancer Institute

Progress Against Breast Cancer

New Cases

90

100

110

120

130

140

150

1973

1975

1977

1979

1981

1983

1985

1987

1989

1991

1993

1995

1997

1999

2001

2003

2005

2007

2009

Year of Diagnosis

Ne

w C

an

cer

Ca

ses

pe

r 1

00

,00

0 P

eo

ple

Source: National Cancer Institute

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