$427

Subject Index

Adjunctive therapy Amifostine, 333, 356, 639, 1182, 1464, 1472, 1479, 1520, 1534, 1539 Antibiotics, 147, 408, 1406, 1462, 1467, 1500, 1541 Other, 45, 69, 96, 368, 400, 472, 580, 761,770, 1129, 1254, 1269,

1457, 1459, 1461, 1481, 1499, 1537, 1546 Alopecia, 101, 1532, 1540, 1543 Anal cancer, 513, 516, 523, 531,553, 578, 1208 Analgesics and narcotics, 45, 96, 1499 Angiogenesis

Antagonists and inhibitors, 357, 683, 884, 992, 1134, 1136, 1137, 1218, 1436

Breast cancer, 359 Cervical cancer, 376, 685 Colorectal cancer, 357 Lung cancer, 385, 420, 990, 992, 996, 1022, 1657 Other, 196, 358, 358, 360, 366, 375, 380, 384, 386, 391,632, 684,

884, 943, 1090, 1427, 1584 Anti-emetics, 69, 761,770, 1459, 1546 Anti-hormones

Anastrozole, 1257, 1258 Tamoxifen, 179,268a, 268b, 271,299, 488, 799,807, 817, 819, 853,

897, 898, 1086, 1257, 1258, 1438, 1519, 1531 Toremifene, 471,594, 1318

Antibodies Therapeutic use, 216, 302, 357, 1261, 1268, 1276, 1281, 1293, 1299,

1388, 1441 Other applications, 241,371,768, 1401, 1416, 1453, 1454

Apoptosis Brain tumor, 443 Colorectal cancer, 250, 683 Leukemia, 753, 760, 1243, 1355, 1372 Lung cancer, 692, 744, 1044, 1567 Lymphoma, 364, 700, 703 Myelodysplasia, 1354 Radiation biology, 390, 682, 689, 693, 699, 700, 702, 703, 710 Sarcoma's, 1071 Tumor markers, 248,745, 1409 Other, 369, 379, 385, 647, 682, 746, 755, 756, 934, 958, 1241, 1242,

1244, 1245, 1409, 1437, 1452, 1503

Biological and immunological agents - other, 2, 425, 543, 767, 1019, 1251, 1440, 1449, 1452, 1458, 1524

Biomedical devices, 44, 122, 1471 Biophysics, 323, 713, 725, 1089 Biotherapy

Bone marrow and stem cell transplantation, 41,334, 1189, 1190, 1191, 1192, 1193, 1194, 1195, 1196, 1197, 1198, 1224, 1227, 1332, 1362

Immunotherapy, 456,457, 474, 485, 525, 562, 1233, 1388, 1408, 1450, 1555

Photodynamic therapy, 323, 403, 713, 725, 1019, 1254 Bladder cancer, 1381, 1382, 1391, 1397, 1398, 1399, 1400, 1401, 1406,

1412, 1413, 1416, 1418, 1420, 1421, 1422, 1424, 1426, 1427, 1428, 1492

Bone metastases, 462,464, 1326, 1483 Brain metastasis, 327, 410, 422, 432, 438, 465, 997 Brain tumours, 406

Chemotherapy, 426, 428, 430, 435, 436, 440, 443 Combined therapy, 441,442, 1350 Imaging, 424 Radiotherapy, 336, 339, 406, 411,425, 427, 429, 434, 439, 1445 Stereotactic radiosurgery, 315, 327, 432, 432, 438 Other, 337, 363, 410, 422,423, 431,433, 437, 465, 997

Breast cancer - adjuvant therapy, 20, 268a, 270, 271,285, 452, 485, 594, 752,790, 798, 800, 801,802, 805, 807, 817, 818, 819, 823, 830, 831,831,888, 896, 897, 899, 902, 1130, 1338, 1538, 1546, 1556

Breast cancer - advanced/metastatic Chemotherapy of recurrence, 1268, 1273, 1278, 1286

Clinical trials, 1174, 1179, 1257, 1259, 1260, 1262, 1263, 1264, 1272, 1274, 1276, 1279, 1285, 1287, 1290, 1291, 1292, 1294, 1298, 1308, 1312, 1316, 1320, 1460

First-line therapy, 1275, 1283, 1286, 1293, 1307, 1324 High dose chemotherapy, 855, 1194, 1195, 1266, 1271, 1288, 1310,

1325, 1327 Prognostic factors, 273, 359, 757, 776, 1289, 1453 Other, 42, 152, 269, 419, 1097, 1184, 1185, 1246, 1261, 1267, 1269,

1280, 1281, 1299, 1302, 1303, 1304, 1306, 1311, 1314, 1315, 1317, 1318, 1319, 1321, 1323, 1326, 1431

Breast cancer - chemotherapy Dosage and schedules, 791,793, 801,852, 1173, 1256, 1259, 1277,

1285, 1303, 1305, 1309, 1310, 1327 Pharmacology and drug resistance, 777, 1171 Regimens and specific agents, 20, 279, 280, 802, 805, 813, 820, 896,

900, 901, 1172, 1264, 1275, 1281, 1293, 1299, 1307, 1312, 1320, 1323

Stem cell support, 1192 Toxicity and complications, 55, 797, 800, 815, 818, 1301, 1527, 1538,

1542 Other, 277, 595, 654, 1226, 1270, 1278, 1282, 1286, 1296, 1304

Breast cancer - ductal carcinoma in situ, 276, 590, 792, 794, 1209 Breast cancer - endocrine therapy, 268b, 272, 295, 467, 471,704, 799,

819, 898, 1176, 1258, 1284, 1316, 1531 Breast - cancer other, 8, 64, 93, 94, 306, 309, 342, 447, 729, 780, 795,

796, 804, 815, 824, 1128, 1189, 1196, 1197, 1295, 1322, 1490 Cell biology and pathophysiology, 281,287, 735, 737, 774, 778, 781,

782 Epidemiology, 161,446, 1112 Hereditary and familial risk, 741,785, 875 Quality of life and psychosocial aspects, 870, 1120, 1131, 1255, 1265,

1284, 1485, 1587 Recurrence, 381 Screening and diagnosis, 275, 289, 588, 591,829,970

Breast cancer- radiation therapy, 299, 314, 329, 338, 343, 349, 590, 593, 792b, 800, 803, 806, 808, 811,814, 821,822, 827, 828, 888, 981, 1209, 1296, 1297, 1313, 1334

Breast cancer - surgery, 107, 275, 293, 481,492, 592, 787, 788, 789, 794, 795, 809, 810, 816, 821,825, 826, 829, 874, 1209, 1246, 1282, 1533, 1560

Breast cancer - tumour markers and prognosis, 272, 274, 278, 283, 284, 286, 288, 290, 291,294, 296, 297, 298, 301,302,303, 304, 305, 307, 308, 310, 388, 392, 419, 595, 690, 709, 726, 727, 728, 752, 773, 775, 779, 783, 845, 1289, 1438

Cancer epidemiology and risk factors - other, 1095 Cancer prevention, 446, 467, 488, 585, 664, 876, 894, 1111, 1113, 1123,

1138, 1203, 1204, 1205, 1517, 1587 Carcinogenesis, 361,393, 483, 540, 557, 588, 696, 727, 737, 1216,

1328, 1429, 1583 Carcinoid tumours and carcinoid syndrome, 835 Cell biology - metastasis, 244, 274, 282, 286, 296, 370, 372, 374, 375,

378, 384, 388, 391,392, 396, 595, 622, 728, 744, 776, 849, 884, 904, 992, 1247, 1302, 1449, 1508, 1510

Breast cancer, 274, 282, 286, 296, 388, 392, 595, 728, 776, 1302 Cell cycle, 486, 702, 786, 873, 1349, 1398, 1572, 1573, 1574, 1576, 1585 Cell proliferation, 246, 248, 303, 362, 369, 382, 385, 393, 423, 599, 618,

761,767, 769, 786, 911, 1213, 1220, 1365, 1366, 1421, 1574 Cervical cancer, 65, 98, 318, 345, 376, 685, 903, 904, 905, 915, 916,

919, 920, 922, 923, 925, 926, 928, 929, 930, 932, 944, 945, 946, 948, 949, 953, 954, 1205, 1429

Chemotherapy- adjuvant, 216, 249, 264, 265, 496, 517, 555, 602, 793, 853, 857, 879, 1075, 1086, 1094, 1231, 1319, 1346, 1423, 1525, 1569

Chemotherapy - administration Cisplatin: gastric cancer, 496, 506, 552 Cisplatin: lung cancer, 973, 998, 1002, 1011, 1018 Cisplatin: melanoma, 1520, 1521

$428 Subject Index

Chemotherapy- administration (continued) Cisplatin: ovarian cancer, 960, 966 Cisplatin: pharmacology and toxicity, 565, 665, 756,766, 927, 966,

1029 Cisplatin: uterine and cervical cancer, 905, 927, 928 Cisplatin: other therapeutic use, 71,497, 504, 522, 537, 1088, 1151,

1169, 1278 Liposomes and drug delivery systems, 626, 1475 Oral administration, 1153, 1171 Routes and schedules, 116, 356, 507, 759, 835, 1159, 1168, 1178,

1182, 1283, 1412 Other, 36, 159, 214, 227, 256, 580, 909, 1004, 1060, 1069, 1234,

1236, 1308, 1311, 1345, 1471, 1492, 1536 Chemotherapy - alkylating agents

Bendamustin, 1009, 1179 Carboplatin: head and neck cancer, 628, 648, 649, 660 Carboplatin: lung cancer, 973, 978, 1014, 1027, 1036, 1040, 1046,

1048, 1052 Carboplatin: ovarian cancer, 448, 907, 908, 910, 914, 933, 939, 941,

962, 966, 971 Carboplatin: other therapeutic use, 435, 532, 1197, 1397 Cisplatin: breast cancer, 1277, 1278, 1281, 1309 Cisplatin: cervix cancer, 905, 919, 928, 929 Cisplatin: gastrointestinal cancer, 71,497, 504, 506, 520, 522, 523,

525, 537, 539, 547, 551,552, 555, 564, 565 Cisplatin: head and neck cancer, 610, 614, 633, 653, 657, 665, 670,

679 Cisplatin: lung cancer, 973, 974, 977, 980, 984, 986, 989, 993, 998,

1001, 1002, 1005, 1011, 1015, 1017, 1018, 1021, 1024, 1028, 1029, 1037, 1041, 1042, 1050, 1051

Cisplatin: ovarium cancer, 908, 938, 960, 972 Cisplatin: other therapeutic use, 497, 504, 506, 522, 523, 537, 551,

552, 610, 766, 915, 929, 1068, 1088, 1151, 1397, 1405, 1520, 1521 Cyclophosphamide: breast cancer, 20, 279, 793, 802, 805, 820, 899,

900, 1260, 1263, 1288, 1304, 1325 Cyclophosphamide: other therapeutic use, 910, 971, 1356, 1359,

1414, 1414 Dacarbazine, 765, 1520 Ifosfamide, 905, 1039, 1042, 1050, 1053, 1077, 1198, 1321, 1435 Oxaliplatin, 92, 225, 237, 239, 256, 257,263, 536, 755, 1000, 1156,

1160, 1163, 1172, 1180, 1529 Other, 430, 747, 759, 854, 1266, 1505

Chemotherapy - antimetabolites 5-Fluorouracil: colorectal, 219, 221,228, 245, 252, 253, 260, 261,265,

5O0 5-Fluorouracil: pharmacology and toxicity, 187, 239, 243, 249 5-Fluorouracih other GI malignancies, 498, 520, 551,582 5-Fluorouracil: other therapeutic use, 614, 657, 835, 835, 1288, 1296,

1303 Gemcitabine, 538, 546, 559, 560, 583, 646, 705, 1012, 1042, 1047,

1054, 1082, 1165, 1183, 1308, 1355 Methotrexate and antifolate agents, 749, 750, 985, 1146, 1188 Other, 226, 247, 443, 522, 537, 545, 558, 1139, 1140, 1141, 1148,

1152, 1153, 1154, 1164, 1167, 1175, 1181, 1294, 1434, 1521 Chemotherapy - antineoplastic antibiotics

Anthracyclines: pharmacology and toxicity, 1161, 1170, 1527, 1543 Anthracyclines: other, 270, 1265, 1538 Bleomycin, 669, 928, 929 Doxorubicin: breast cancer, 279, 790, 791,613, 900, 1256, 1260,

1263, 1263, 1267, 1304, 1312, 1324 Doxorubicin: sarcomas, 1082 Doxorubicin: other therapeutic use, 355, 507, 772, 1359 Epirubicin: breast cancer, 270, 285, 793, 805, 1173, 1277 Epirubicin: lung cancer, 1011, 1023 Epirubicin: other tharapeutic use, 558, 907, 959, 1068, 1068, 1088,

1356 Mitomycin, 225, 498, 515, 561,561,600, 929 Other, 1155, 1178

Chemotherapy - camptothecins, 909, 933, 965, 972, 1004, 1169 Irinitecan, 206, 213, 220, 262, 253, 260, 440, 515, 551,989, 1028,

1037, 1038, 1138, 1175 Chemotherapy - combination chemotherapy regimens

Anthracyclines, 558, 793, 831, 1164, 1173, 1260, 1263, 1272, 1317, 1324, 1359

Carboplatin, 532, 907, 914, 933, 941,966, 971,973, 1014, 1046, 1049, 1146, 1231, 1397, 1400, 1568

Cisplatin, 497, 504, 647, 551,552, 633, 666, 670, 679, 905, 908, 919, 940, 972, 998, 1001, 1002, 1017, 1021, 1042, 1050, 1068, 1088, 1169, 1177, 1277, 1397, 1405, 1425, 1520, 1522

Docetaxel, 565, 575, 604, 633, 790, 937, 962, 966, 1017, 1026, 1156, 1158, 1165, 1174, 1305, 1325

Irinotecan, 206, 213, 219, 220, 252, 253, 260, 515 Oxaliplatin, 237, 239, 257, 263, 536, 1000, 1156, 1160, 1163, 1172 Paclitaxel, 679, 793, 905, 908, 941,973, 1001, 1015, 1024, 1049,

1277, 1287, 1291, 1294, 1306, 1410, 1519, 1568 Topotecan, 965, 972, 1001, 1169 Vinorelbine, 670, 919, 937, 964, 977, 987, 1014, 1031, 1036, 1039,

1046, 1050, 1287, 1305, 1426 Other, 221,228, 232, 233, 436, 556, 572, 573, 582, 583, 586, 669,

749, 750, 765, 1010, 1032, 1063, 1064, 1085, 1145, 1148, 1162, 1175, 1198, 1271, 1274, 1275, 1315, 1335, 1337, 1356, 1361, 1369, 1379, 1383, 1391

Chemotherapy - drug interactions, 356, 619, 749, 760, 761,770, 914, 1051, 1136, 1318

Chemotherapy - drug metabolism and pharmacokinetics Drug distribution and metabolism, 157, 762, 771, 1167, 1220, 1236 Pharmacokinetics: 5-fluorouracil, 232, 261,777, 1136 Pharmacokinetics: anthracyclines, 797, 1136, 1136, 1161, 1170, 1171,

1318 Pharmacokinetics: carboplatin, 914 Pharmacokinetics: irinotecan, 1058, 1138 Pharmacokinetics: methotrexate, 1072, 1158, 1188 Pharmacokinetics: paclitaxel, 1273, 1294 Pharmacokinetics: topotecan, 914, 1186 Pharmacokinetics: vinorelbine, 1044 Pharmacokinetics: other, 750, 751, 1134, 1136, 1139, 1140, 1141,

1145, 1147, 1148, 1152, 1153, 1154, 1158, 1159, 1166, 1168, 1176, 1184, 1185, 1237

Chemotherapy - drug resistance, 215, 263, 379, 426, 430, 448, 489, 674, 745, 747= 746, 752, 754, 757, 758, 760, 763, 764, 766, 768, 772, 777, 958, 985, 1183, 1188, 1193, 1233, 1245, 1264, 1273, 1292, 1365, 1366, 1411, 1463, 1574

Chemotherapy - epipodophyllotoxins Other, 959, 1166, 1385, 1535 Etoposide: lung cancer, 980, 964, 998, 1005, 1012, 1023 Etoposide: other therapeutic use, 364 Other, 37, 155, 851,910, 935, 939, 1190, 1226, 1337, 1345, 1362,

1555 Toxicity and complications, 159, 1081, 1463, 1464

Chemotherapy - high dose chemotherapy with PBSCIABMT Breast cancer, 122, 854, 855, 1189, 1192, 1194, 1195, 1197, 1266,

1327, 1431, 1546 Chemotherapy- neo-adjuvant chemotherapy

Breast cancer, 279, 790, 791,798, 813, 900, 901, 1267, 1304, 1312, 1323

Head and neck cancer, 615, 667, 675, 877 Lung cancer, 1018, 1032, 1668 Other, 210, 417, 525, 539, 570, 657, 856, 857, 929, 944, 1061, 1073,

1077, 1093, 1207, 1230 Chemotherapy - regional

Chemo-embolization, 580 Intra-arterial administration, 509, 535, 748, 1059, 1497 Intra-vesical administration, 110, 1382, 1401, 1420 Intrahepatic administration, 71,500, 537 Intraperitoneal administration, 229, 509, 541,555, 569, 964 I ntratumoral administration, 522, 1278, 1521 Other, 957, 1252, 1435

Chemotherapy - taxolds Docetaxel: breast cancer, 798, 901, 1157, 1174, 1259, 1265, 1298,

1305, 1311, 1325 Docetaxel: lung cancer, 1008, 1017, 1026, 1033, 1043 Docetaxel: other therapeutic use, 104, 577, 584, 614, 633, 915, 937,

960, 962, 966, 1158, 1165 Paclitaxel: breast cancer, 1273, 1277, 1291, 1292, 1311 Paclitaxel: ovarian cancer, 937, 959 Paclitaxel: pharmacology and toxicity, 1182, 1306, 1310, 1632, 1544 Paclitaxel: other therapeutic use, 648, 660, 679, 973, 974, 1001, 1005,

1015, 1024 Other, 506, 574, 604, 746, 751,900, 979, 1092, 1142, 1145, 1147,

1260, 1272, 1283, 1285, 1290, 1309, 1315, 1324, 1519, 1543 Chemotherapy - vinca alkaloids

Vinblastine, 367, 1397 Vincristine, 669, 1356 Vinorelbine, 1536 Vinorelbine: breast cancer, 805, 1287, 1290, 1309, 1320, 1323 Vinorelbine: lung cancer, 987, 999, 1014, 1031, 1036, 1039, 1046,

1050, 1053 Vinorelbine: other therapeutic use, 670, 919, 937, 964

Subject Index $429

Chemotherapy - vinca alkaloids (continued) Other, 420

Chemotherapy- other, 222, 225, 234, 256, 258, 514, 536, 544, 582, 755, 922, 960, 1080, 1134, 1135, 1143, 1144, 1149, 1150, 1151, 1159, 1168, 1181, 1187, 1218, 1261, 1372, 1452, 1523

Clinical research, 82, 113, 118, 185, 444, 1470 Colorectal cancer - advanced/metastatic

Therapy, 71, 187, 205, 206, 210, 213, 217, 219, 221,223, 225, 228, 232, 233, 234, 237, 247, 252, 253, 256, 258, 260, 261,263, 353, 479, 500, 892

Other, 204, 230, 241,254, 1497, 1558 Colorectal cancer - chemotherapy

5-Fluorouracil, 205, 212, 215, 220, 221,243, 245, 249, 257, 261, 1160 Cost analysis, 187, 207, 214 Irinotecan, 225, 235 Liver metastasis, 210, 251,500 Quality of life, 206, 254 Other, 222,265, 449, 1529

Colorectal cancer - surgery, 1,200, 208, 236, 259 Colorectal cancer- other, 208, 731,859, 1203

Biology and pathophysiology, 250, 733 Radiation therapy, 50

Communication, 11, 17, 123, 137, 148, 164, 168, 870, 1100, 1101, 1102, 1103, 1104, 1106, 1108, 1118, 1127, 1457, 1470, 1473, 1476, 1590

Complementary therapy, 72, 473, 474, 475 Conventional surgery, 200, 293, 478, 512, 518, 530, 625, 787, 836, 840,

858, 903, 1060, 1079, 1084, 1346, 1563 Counselling, 72, 148, 177, 876, 1108, 1133, 1589 Cytogenetics, 197, 396, 445, 702, 732, 734, 735, 736, 1424 Cytokines and immunological agents

G-CSF and GM-CSF, 942, 1388, 1412, 1450, 1492 Physiology and pathophysiology, 363, 956, 1341, 1526 Other therapeutic agents, 636, 698, 1021, 1130, 1241, 1252, 1408,

1440, 1443, 1445, 1447, 1555 Cytology, 289, 706, 967, 1369

Diagnostic imaging Pet and computed tomography, 597, 627, 1267, 1506 Radionuclide imaging, 502, 591,812 Other, 197, 550, 553, 709, 794

Education, 22, 46, 76, 77, 113, 118, 121,140, 147, 161,183, 199, 200, 451,871, 1102, 1116, 1128, 1133, 1200, 1577, 1579, 1580

Elderly Cancer biology, 418, 1422 Socio-economics, 57, 58 Therapy, 258, 987, 1025, 1040, 1309, 1340

Endocrine therapy - other, 1184, 1185, 1270 Endocrinology

Cell biology, 272, 287, 295, 300, 468, 784 Endometrium and uterus

Endometria[ cancer, 373, 730, 743, 916, 921,927, 931,943, 947, 950, 951,955

Uterine neoplasms, 345, 915, 924 Epidemiology

Breast cancer, 785 Cervical cancer, 916 Colorectal cancer, 262 Gastric cancer, 505, 563, 739 Lymphoma, 1110, 1353, 1368 Ovarian cancer, 448, 970, 1103 Paediatric oncology, 411,412, 1099, 1109 Prostate cancer, 1407, 1562 Quality assurance, 478, 894, 897, 1132 Testicular cancer, 1395 Other, 446, 473, 567, 1087, 1094, 1112, 1113, 1342, 1496

Ethics, 95, 177, 179, 185, 451,842 Ewing's sarcoma, 405, 410,413, 735, 893, 1066

Gastrointestinal malignancies- other, 502, 524, 569, 1557 Gene expression and regulation, 215, 255, 272, 285, 379, 433, 445,

468, 470, 728, 733, 740, 746, 754, 774, 784, 844, 873, 1328, 1349, 1380, 1404, 1503, 1511, 1565

Gene marking, 433, 743 Gene therapy, 882, 883, 884, 885, 1434, 1435, 1436, 1437, 1446 Genetic techniques, 178, 242, 283, 470, 494, 495, 729, 781,844, 846,

849, 850, 883, 886, 1329, 1567 Genitourinary malignancies - other, 1405, 1410 Gonadotropins, 266, 268b, 819, 898

Good clinical practice Nursing care, 34, 84, 87, 92, 113, 120, 136, 145, 186 Radiotherapy, 146, 317 Surgical oncology, 193, 477 Other, 23, 32, 39, 82, 106, 115, 116, 118, 119, 126, 150, 159, 183, 185,

188, 211,394, 448, 454, 455, 871,896, 1003, 1074, 1095, 1096, 1100, 1116, 1233, 1512, 1514, 1577

Growth hormones and telomerases Growth factors: biology and cell physiology, 196, 359, 376, 382, 383,

782, 968 Telomerase activity, 373, 923, 1404

Gynecologic malignancies- other, 906, 1124, 1507, 1516, 1542

Head and neck cancer - other Chemotherapy, 366, 606, 610, 628, 633, 638, 642, 646, 653, 657, 660,

665, 669, 672, 678, 879, 1534 Radiotherapy, 61,326, 332, 466, 596, 598, 618, 623, 625, 640, 653,

654, 666, 671,673, 678, 691 Other, 7, 597, 607, 612, 616, 622, 626, 629, 630, 635, 637, 647, 651,

652, 659, 662, 674, 1559 Health economics, 187, 189, 190, 191,207, 567, 686, 899, 1063, 1189,

1253, 1265, 1513 Hepatobiliary neoplasms, 251,351,479, 499, 517, 526, 532, 537, 548,

559, 560, 566, 585, 1177, 1239, 1369, 1437, 1583 Hereditary and familial cancer risk

Breast/ovarian cancer, 588, 736, 785, 874, 1111, 1213, 1214 Other, 177, 180, 181, 182, 231,696, 739, 876, 1203, 1212, 1501

Hodgkin's disease Staging and prognosis, 1331, 1333, 1340, 1344, 1348, 1364 Other, 889, 1334, 1336, 1337, 1343, 1371, 1552, 1582

Hormone antagonists, 897, 1086, 1378

Immunosuppreasion and myelotoxicity, 507, 574, 971, 1157, 1166, 1331, 1385, 1462, 1463, 1481, 1482, 1500, 1530, 1541, 1545

Infectious diseases HIV infections, 1537, 1584 Nosocomial infections and infection control, 408, 1191, 1458, 1462,

1463, 1466, 1541 Interferons

Physiology and other therapeutic use, 264, 562, 698, 834, 1062, 1314, 1456, 1525

Renal cell carcinoma, 1443 Interleukins

Intedeukin-2: physiology and other therapeutic use, 669, 1011, 1450 Interleukin-2: renal cell carcinoma, 1451 Interleukin-4, 460, 1439, 1445, 1447, 1452 Interleukin-6, 954 Other, 882, 885, 1446

Kidney neoplasms, 387, 456, 1404, 1408, 1419, 1443, 1451

Laryngeal cancer, 599, 604, 608, 624, 631,632, 636, 641,644, 645, 649, 650, 651,656, 657, 664, 667, 668, 670, 679, 880, 1206

Leukemia, 395, 402, 753, 1110, 1328, 1332, 1338, 1342, 1354, 1355, 1361, 1366, 1370, 1372, 1374

Liver metastases, 251,500 Lung cancer, non-small cell - chemotherapy, 584, 974, 976, 977, 978,

979, 985, 986, 987, 989, 993, 998, 999, 1002, 1008, 1010, 1011, 1012, 1014, 1015, 1016, 1017, 1020, 1022, 1024, 1025, 1026, 1028, 1029, 1031, 1032, 1033, 1036, 1037, 1039, 1040, 1042, 1043, 1044, 1046, 1047, 1048, 1049, 1050, 1051, 1052, 1053, 1054, 1055, 1180, 1570

Lung cancer, non-small cell - combined modality therapy, 988, 992, 1007, 1013, 1018, 1019, 1029, 1044, 1568, 1569, 1571

Lung cancer, non-small cell - surgery, 1035 Lung cancer - radiotherapy, 331,708, 722, 722, 863, 975, 983, 1032,

1045 Lung cancer, small ce l l - chemotherapy, 980, 984, 1001, 1004, 1005,

1009, 1023, 1027, 1038, 1041 Lung cancer, small cell - combined modality therapy, 768, 997, 1005 Lung cancer, small cell - surgery, 1498 Lung cancer - tumour markers and prognosis, 361,982, 990, 994,

995, 996, 1020 Lung cancer- other, 267, 420, 973, 974, 981,991, 1006, 1019, 1030,

1034, 1053, 1057, 1449, 1534

Melanoma Biology and pathophysiology, 1454, 1455, 1501, 1502, 1503, 1504,

1508, 1510, 1518, 1526

$430 Subject Index

Melanoma (continued) Chemotherapy, 1505, 1509, 1519, 1520, 1521, 1522, 1523 Immunotherapy and vaccines, 264, 460, 1433, 1442, 1513, 1524, 1525 Prognosis and staging, 1295, 1506, 1515, 1516, 1517 Other therapeutic modalities, 14, 1443, 1512, 1514, 1561

Mesothelioma, 1000, 1021, 1056, 1070, 1146 Metastasis

Breast cancer, 274, 282, 286, 296, 388, 392, 595, 728, 776, 1302 Colorectal cancer, 206, 207, 210, 221,228, 247, 370 Lung cancer, 744, 992, 1449 Other, 244, 372, 374, 375, 378, 384, 391,396, 622, 849, 884, 904,

1247, 1508, 1510 MucosiUs and stomatitis, 243, 333, 603, 634, 639, 666, 671, 1193, 1547 Multimodality approach, 183, 209, 251,350, 454, 472, 479, 492, 498,

564, 675, 832,890, 1206, 1210 Multiple myeloma, 418, 421, 1179, 1224, 1339, 1358, 1359, 1365, 1440,

1460 Myelodysplasia and other hematologic disorders, 1354, 1374

Nausea and vomiting, 69, 1459, 1538 Neuro-oncology - other, 427, 710, 1065 Non-Hodgkin's lymphoma

Chemotherapy and radiotherapy, 328, 364, 757, 1225, 1331, 1335, 1350, 1351, 1352, 1356, 1363, 1373, 1375, 1551

Immunotherapy and bone marrow transplantation, 1362, 1554 Prognosis and staging, 421, 1330, 1345, 1346, 1347, 1349, 1357, 1360 Other, 445, 846, 1110, 1329, 1341, 1353, 1368, 1582

Nursing -advanced technology, 2, 29, 34, 35, 36, 62, 102, 109, 124, 125, 138, 145, 157, 163, 164, 173, 189, 192

Nursing- clinical practice, 4, 11, 17, 18, 19, 25, 26, 28, 29, 31, 32, 37, 44, 49, 51, 60, 62, 66, 71, 73, 74, 78, 85, 87, 101, 102, 108, 110, 111, 112, 114, 115, 116, 120, 122, 124, 128, 129, 130, 135, 137, 138, 139, 141, 143, 149, 152, 154, 158, 160, 162, 163, 169, 173, 176, 476, 1536, 1581

Nursing- education, 5, 6, 9, 13, 22, 26, 28, 32, 46, 52, 67, 77, 88, 106, 111,115, 117, 120, 124, 130, 131, 139, 141, 147, 150, 155, 158, 164, 165, 168, 169, 173, 184

Nursing- management, 8, 15, 17, 28, 44, 82, 88, 92, 96, 109, 154, 155, 158, 160, 167, 168, 192, 603

Nursing - other, 2, 3, 6, 7, 9, 20, 21, 24, 45, 48, 51, 70, 75, 77, 79, 81, 108, 112, 123, 127, 143, 151,156, 166, 172

Nursing - rehabilitation, 21, 30, 41, 89, 94, 97, 170 Nursing - research, 4, 10, 18, 27, 31, 38, 40, 41, 42, 46, 47, 49, 50, 53,

54, 55, 56, 57, 58, 59, 60, 62, 63, 65, 66, 67, 69, 70, 73, 74, 83, 84, 85, 86, 87, 88, 90, 91,93, 94, 100, 107, 110, 114, 130, 132, 133, 135, 144, 145, 146, 148, 157, 167, 176, 179, 184, 186, 189, 476, 1581

Nursing care Bone marrow transplantation, 37, 117, 143 Breast cancer, 64, 103, 108 Chemotherapy administration, 12, 20, 29, 104, 139 Infection control, 46 Pain control, 99 Pediatric oncology, 28, 31 Professionalism and career development, 13, 19, 33, 84, 142, 174, 184 Radiotherapy, 18, 50, 70, 90, 127 Stem cell collection, 117 Terminal and palliative care, 9, 16, 25 Other, 6, 51, 98, 109, 129, 137, 172, 175, 176, 476

Nutrition and diet, 48, 474

Oesophageal cancer, 348, 477, 496, 504, 512, 518, 519, 520, 522, 525, 528, 530, 533, 534, 539, 550, 570, 573, 581,687, 856, 1207

Oncogenes Bcl-2, 277, 288, 753, 1280, 1452, 1503 ErbB-2 (HER-2/NEU), 240, 273, 280, 290, 305, 485, 728, 912 Other, 224, 362, 482, 483, 484, 486, 696, 730, 740, 741,742,776,

779, 1215, 1217, 1341, 1429, 1502, 1572, 1585 Orbital and ocular tumours, 312, 321,335, 399, 412, 417, 680 Osteosarcoma, 30, 413, 734, 893, 1063, 1064, 1066, 1072, 1077, 1080,

1090, 1092, 1093, 1211 Ovarian cancer

Biology and pathophysiology, 374, 848, 911,912, 934, 956, 958, 967, 969

Chemotherapy, 100, 907, 908, 909, 911,914, 933, 935, 937, 938, 939, 940, 941,942, 957, 959, 960, 982, 963, 964, 965, 966, 971,972, 1230, 1249

Other, 448, 913, 936, 961,968, 970, 1103, 1228, 1229, 1231, 1233, 1234

Paediatric oncology- leukemias, 401,403, 407, 415, 416, 1099, 1109, 1223, 1227, 1430

Paediatri¢ oncology- solid tumours Brain turnouts, 313, 406, 407, 441, 1152 Retinoblastoma, 399, 412, 417 Sarcomas, 322, 379, 404, 1064 Other, 380, 398, 400, 403, 409, 864, 1199

Paediatrlc oncology- other, 394, 403, 411,412, 414, 417, 566, 716, 842, 864, 1548

Pain, 36, 52, 64, 76, 96, 99, 105, 138,269, 450, 462, 464, 666, 811, 1486, 1489, 1495, 1499

Pancreatic cancer Chemotherapy and radiotherapy, 497, 498, 514, 521,527, 532, 535,

536, 538, 544, 546, 547, 556, 564, 567, 576, 582, 583, 586, 762, 1435

Surgery, 587 Other, 543, 575, 579, 717, 721,858

Pathological diagnosis, 276, 281,282, 292, 323, 377, 611,713, 845, 1240, 1330, 1390, 1396, 1399

Pharyngeal cancer, 605, 608, 611,613, 617, 620, 621,627, 636, 641, 643, 648, 649, 651,655, 658, 661,663, 676, 684, 877, 881

Photodynamic therapy, 323, 725, 1019, 1254 ProgestaUonal agents, 1011 Prognostic factors

Bladder cancer, 1382, 1398, 1399, 1420, 1427 Brain turnouts, 380, 428, 441 Breast cancer, 279, 280, 284, 286, 288, 294, 296, 298, 299, 300, 304,

309, 310, 775, 779, 780, 786 Colorectal cancer, 203, 211,230, 240 Endometrial cancer, 924, 943 Gastric cancer, 389, 568 Head and neck cancer, 596, 605, 622, 632, 655, 674, 1559 Leukemia, 395,402 Lung cancer, 994, 996, 1035 Lymphoma, 396, 846, 1330, 1357, 1373 Melanoma, 1504, 1508, 1511 Metastasis, 1391 Ovarian cancer, 848, 912, 934 Prostate cancer, 1392 Soft tissue sarcoma, 1076 Testicular cancer, 1386 Other, 493, 526, 734, 748, 904, 925, 1067, 1070, 1354, 1477

Prostate cancer Chemotherapy and endocrine therapy, 266, 1378, 1379, 1392, 1411,

1414, 1566 Radiotherapy, 319, 464, 862, 1376, 1377, 1387, 1389, 1394, 1415,

1564 Other, 450, 1202, 1238, 1380, 1388, 1396, 1407, 1409, 1562, 1563,

1565 Psychological oncology, 97, 156, 181,475, 867, 1101, 1102, 1104,

1107, 1108, 1114, 1115, 1119, 1127, 1129, 1269, 1469, 1470, 1476, 1478, 1486, 1488, 1493, 1588, 1589, 1591

Psychosocial oncology, 27, 41, 53, 65, 68, 72, 91, 144, 153, 156, 161, 181,461,870, 872, 1100, 1103, 1105, 1107, 1111, 1114, 1115, 1117, 1119, 1126, 1129, 1130, 1131, 1487, 1587, 1590

Quality assurance, 17, 23, 34, 39, 82, 121,125, 126, 167, 185, 186, 316, 317, 336, 339, 342, 350, 454, 832, 894, 940, 1089, 1106, 1128, 1496, 1514, 1577, 1579

Quality of life Breast cancer, 95, 269, 1131, 1255, 1262, 1265, 1276, 1485, 1490 Colorectal cancer, 206, 208, 214, 254 Head and neck cancer, 335, 626, 639, 654, 675, 1206 Lung cancer, 979, 993, 1009, 1045, 1498 Melanoma, 1520 Pancreatic cancer, 527 Prostate cancer, 1127, 1394 Radiotherapy, 146, 335, 1045, 1119, 1465, 1488, 1489 Other, 10, 16, 25, 30, 37, 54, 72, 73, 89, 97, 101, 105, 140, 151, 152,

169, 188, 191,428, 450, 461,475, 867, 869, 870, 871,872, 1104, 1106, 1107, 1115, 1117, 1118, 1126, 1248, 1457, 1461, 1467, 1468, 1478

Radiation oncology- adjuvant radiotherapy Bladder cancer, 346, 347 Breast cancer, 349, 593, 792b, 803, 806, 822, 888 Endometrial cancer, 931,947, 951 Gastrointestinal cancer, 508, 528, 533, 542, 860 Head and neck cancer, 603, 627

Subject Index $431

Radiation oncology - adjuvant radiotherapy (continued) Lung cancer, 356, 1569 Seminoma, 1384 Other, 406, 437, 841, 1067, 1367, 1375

Radiation oncology- brachytherapy Breast cancer, 338, 821,827 Esophageal cancer, 348, 512, 519, 528, 533 Gynecologic oncology, 98, 318, 903, 918, 951 Head and neck cancer, 326, 613, 676 Prostate cancer, 1376, 1394 Other, 259, 353, 1199

Radiation oncology - conformal radiotherapy Neuro-oncology, 313, 315, 340, 432, 438, 1065 Prostate cancer, 125, 319, 1376, 1377, 1387, 1564 Other, 311,322, 324, 331,332, 337, 341,351,354, 520, 527, 531,

661,687, 862, 863, 864, 865, 983, 1250 Radiation oncology- dosimetry and treatment verification, 311,314,

315, 316, 325, 329, 330, 331,349, 352, 1250, 1415 Radiation oncology- hypoxia and oxygen delivery, 601,609, 612,

619, 652, 688, 691,695, 711,721,723, 725 Radiation oncology- modification of radiation response, 194, 266,

491,600, 601,615, 682, 683, 689, 694, 711,715, 718, 1055, 1062, 1419

Radiation oncology- normal tissue morbidity, 313, 350, 409, 491, 697, 708, 712, 714, 716, 724, 792b, 796, 803, 862, 1378, 1479, 1545

Gastrointestinal effects, 209, 693, 701,719 Skin reactions, 344, 707, 827

Radiation oncology-pal l iat ive radiotherapy, 50, 217, 320, 422, 462, 464, 466, 514, 686, 1297, 1326, 1389, 1473, 1474, 1479, 1480, 1483, 1488, 1505

Radiation oncology - predictive factors and assays, 299, 491,609, 615, 618, 619, 621,684, 688, 736, 946, 1125, 1377

Radiation oncology- radiation biology Experimental models, 682, 689, 690, 692, 694, 695, 697, 698, 699,

700, 702, 703, 704, 705, 710, 711,712, 714, 717, 719, 762 Other, 194, 693, 709, 716, 718, 722, 1121, 1381, 1408, 1545, 1572

Radiation oncology- radio-chemotherapy Anal and colorectal cancer, 201,203, 218, 223, 226, 238, 516, 531,

861, 1208 Bladder cancer, 247, 346, 355, 1397, 1400, 1422 Breast cancer, 715, 801, 1296 Esophageal cancer, 518, 519, 520, 525, 534, 539, 581,687, 1207 Gynecologic oncology, 915, 917, 920, 928, 953, 963 Head and neck cancer, 7, 332, 366, 466, 600, 602, 608, 610, 628, 638,

640, 641,643, 646, 648, 649, 653, 658, 660, 672, 678, 718,833, 881 Lung cancer, 988, 1013, 1033, 1054 Lymphoma, 1336, 1343, 1344 Neuro-oncology, 442 Pancreatic cancer, 546, 564 Soft tissue and musculoskeletal neoplasms, 724, 1078 Other, 198, 498, 544, 705, 725, 1383, 1465

Radiation oncology - radiotherapy modifiers, 198, 425, 688, 699, 715, 721, 1055, 1297, 1479, 1539

Radiation oncology- techniques Bladder cancer, 346, 347, 1428 Breast cancer, 314, 329, 343, 814, 822 Gastrointestinal oncology, 353 Head and neck cancer, 324, 326, 596, 613, 661 Melanoma, 312, 321 Neuro-oncology, 327, 340, 434 Prostate cancer, 319, 1389 Skin cancer, 328 Other, 311,318, 320, 322, 334, 335, 336, 337, 339, 341,344, 345,

352, 354, 686, 983, 1417 Radiation oncology - time dose fractionaUon

Breast cancer, 593, 1326 Gastrointestinal oncology, 217 Head and neck cancer, 600, 640, 653, 658 Neuro-oncology, 439 Other, 198, 1381, 1387, 1428

Radiation oncology- total body irradiation, 334, 344, 352, 712 Radiation oncology-other, 317, 354, 720, 891, 1254, 1417, 1493

Breast cancer, 808, 811, 1313 Gastrointestinal oncology, 571,975 Head and neck cancer, 61,598, 634, 663, 673, 677 Neuro-oncology, 429 Testicular neoplasms, 1403 Uterine cancer, 921

Receptors and signal transduction, 244, 357, 370, 371,378, 468, 469, 482, 483, 484, 485, 486, 784, 911, 1137, 1215, 1251, 1436, 1518, 1584

Rehabilitation, 14, 93, 95, 170, 1126 Retinoids, 267, 664, 1374 Risk factors, 262, 277, 290, 306, 381,395, 402, 446, 499, 505, 540, 620,

668, 732, 737, 741,743, 849, 932, 947, 948, 981,991, 1097, 1098, 1099, 1105, 1109, 1113, 1124, 1191, 1342, 1370, 1407, 1517, 1583

Screening and surveillance, 43, 57, 361,499, 588, 589, 923, 924, 932, 948, 954, 970, 1202, 1204, 1205, 1235, 1390, 1432, 1562

Second primary neoplasms, 399, 510, 1098, 1338, 1531 Skin cancer- other, 323, 607, 680, 841, 1122 Soft tissue neoplasms- other, 413, 1065, 1076, 1078, 1079, 1313 Soft tissue sarcoma

Biology and pathophysiology, 1071, 1080, 1090 Chemotherapy, 765, 1059, 1060, 1061, 1068, 1073, 1082, 1083, 1086,

1088, 1092, 1198 Multi-modality treatment, 893, 1078, 1091, 1210 Prognosis and staging, 1069, 1075, 1076, 1088 Radiotherapy, 1062, 1067 Surgery, 1067, 1084 Other, 1074, 1081, 1085, 1087

Staging, 283, 292, 502, 553, 578, 591,804, 812, 847, 954, 975, 995, 1238, 1240, 1348, 1390, 1506, 1511, 1561, 1563

Stomach Gastric cancer: Biology and pathophysiology, 389, 511,540, 557, 568,

739, 742 Gastric cancer: Chemotherapy, 496, 506, 507, 509, 515, 529, 545,

551,552, 555, 558, 561,565, 572, 573, 577, 755, 1164, 1177 Gastric cancer: immunotherapy, 562 Gastric cancer: radiotherapy, 508, 542, 571 Gastric cancer: surgery, 478, 510, 549, 583 Gastric cancer: other, 505, 541,857, 1357

Supportive care Alopecia prevention, 101, 102, 1532, 1540, 1543 Anemia, 368, 1191 Anemia - erythropoietin treatment, 92, 400, 1190, 1461, 1465, 1481,

1482, 1494, 1528, 1530 Anti-emetics and emesis control, 639, 1459 Antibiotic therapy, 147 Complementary medicine, 472, 474 Home care, 191, 192 Neutropenia, 1467 Paediatric oncology, 400 Pain control, 1489 Psychosocial care, 68, 149, 153, 461, 1478, 1487, 1491 Radiotherapy, 1474 Stem cell transplantation, 1222 Vaccination, 1458 Other, 1, 141, 170, 671, 1101, 1464, 1468, 1472, 1475, 1493, 1495,

1539 Suppressor genes

CDKN2A, 1501, 1502, 1573 P27 expressions and actions, 423 P53 expressions and actions, 303, 495, 526,692, 742,874, 1360, 1421 P53 mutation, 224, 982, 994 Other, 393, 431,756, 778, 850, 950, 1212, 1213, 1216, 1380

Surgical oncology- conserving and reconstructive surgery Breast cancer, 107, 787, 825 Colorectal cancer, 202, 1208 Head and neck cancer, 607, 630, 636, 642, 680 Orthopedic ontology, 1066, 1089, 1210 Other, 14, 707, 918, 952

Surgical oncology- intraoperative radiotherapy, 341,434, 508, 701, 708, 724, 814, 861

Surgical oncology- isolated organ per'fusion, 575, 957, 1059, 1183, 1252

Surgical oncology-lymphadenectomy, 275, 292, 293, 789, 809, 810, 812, 826, 838, 858, 1533, 1556, 1559, 1560, 1561

Surgical oncology- mastectomy, 8, 108, 795, 803, 888, 1111 Surgical oncology- metastasis, 210, 241,289, 597, 659, 701, 1295,

1518 Surgical oncology- minimal access and endoscopic surgery, 510,

829, 881, 1239, 1498 Surgical oncology-palliative surgery, 587, 929, 1069, 1490, 1497 Surgical oncology- surgery of Iocoregional recurrence, 229, 541,

1247, 1300 Surgical oncology-surgical staging, 501,838, 1234, 1556

$432 Subject Index

Surgical ontology-other, 1254, 1469, 1475, 1476 Breast cancer, 492, 795, 1533 Esophageal cancer, 477 Gastric cancer, 509 Head and neck cancer, 862 Ovarian cancer, 1230 Patient care, 114 Thyroid cancer, 398, 833

Terminal care, 11, 16, 119, 121, 153, 869, 1469, 1473, 1474, 1477 Testicular cancer, 851, 1098, 1347, 1383, 1384, 1385, 1386, 1393, 1395,

1402, 1403, 1423, 1425 Thoracic neoplasms-other, 149, 1003, 1023, 1058 Thyroid cancer and other endocrine neoplasms, 324, 398, 738, 764,

832, 833, 834, 836, 837, 838, 839, 840, 1215, 1235 Toxicity and complications of treatment

Cardiac toxicity, 797, 1527 Fatique, 54, 55, 56, 91, 168 Gastrointestinal toxicity, 238, 243 Haematologic disorders, 643, 1182, 1195, 1542 Neuropathy and neurotoxicity, 100, t529 Thyroid toxicity, 1343 Xerostomia, 654, 1534 Other, 60, 66, 89, 104, 150, 328, 642, 796, 799, 823, 826, 906, 1030,

1034, 1040, 1258, 1367, 1528, 1535, 1544 Tumour biology

Bladder cancer, 1424 Breast cancer, 281,282, 284, 288, 388, 392, 726, 773, 775, 776, 780 Colorectal cancer, 242, 378, 501,733, 847 Head and neck cancer, 637, 723 Lung cancer, 382, 744, 982, 1022, 1057, 1567 Lymphoma, 364, 1329, 1548 Melanoma, 1454, 1455 Mesothelioma, 385 Neuro-oncology, 363, 426, 431 Prostate cancer, 1565 Radiation biology, 390

Renal ceil carcinoma, 384 Sarcomas, 850, 1071, 1584 Testicutar cancer, 756, 1432 Other, 358, 362, 367, 368, 369, 372, 375, 383, 386, 494, 685, 694,

767, 770, 1137, 1247, 1358, 1448 Tumour environment, 367, 389, 601,612, 652, 683, 685, 691,723, 782,

968, 1220, 1237, 1368, 1526 Tumour immunology

Breast cancer, 302, 783 Colorectal cancer, 250 GI/GU malignancies, 456, 942, 961 Vaccine and immunotherapy development, 457, 460, 844, 1416, 1430,

1432, 1446, 1450, 1455 Other, 371,381,458, 1241, 1448

Tumour markers Apoptosis, 1409 Breast cancer, 273, 298, 304, 307, 419, 845 Colorectal cancer, 230, 255 Gene expression and genetic markers, 240, 361,423, 501,845, 967,

1216, 1409 Growth factors, 1504 Head and neck cancer, 621,655 Lymphoma, 421 Melanoma, 1504 Myeloma, 418 Ovarian cancer, 967, 969 Prostate cancer, 1392, 1409 Telomerase activity, 373 Other, 358, 372, 494, 720, 758, 890, 1418

Tumour vaccines, 456, 458, 460, 474, 882, 885, 1430, 1431, 1433, 1439, 1442, 1445, 1447, 1454, 1455, 1582

Unknown primary and other tumours, 503, 509, .574, 1086, 1094, 1156, 1181, 1537

Vaginal neoplasms, 918, 952