12 Subject index

The letters after the number mean: F formula, T table, 5 schematic or photographic representa­tion. Abbreviations are included

Abscesses 78Absorption spectra, benzidine, peroxid-

ase 705N-Acetyl-~-glucosaminidase 43Acid nonspecific esterase 43Acid phosphatase 43Adrenal gland 245Adrenaline 5, 65, 7, 8T, 12,22,23,24Adrenaline method 6Aeration method 18- incubation instruments 205Alcian blue 99, 1005, 101Aldehyde oxidase 60Allor none law 86, 167Amino acid oxidase 60Amino acids 73, 95, 160, 168Antibacterial factors 73, 77Antibodies 43, 161Antigen 88, 895,90, 95, 109, 122Antiviral phenol polymers 168APUD - cell system 65, 22, 24, 25Aquired immune deficiency syndrome,. AID5168Aromatic acids 72 T- amines 72TArterenol 8TAscorbic acid 12, 13F, 14T, 625, 72TAutoantigens 161, 165Autoantibodies 139

Bacteria 59, 71 T, 72, 73, 75, 76, 78,131, 134, 135, 1635, 168

Basal cells 6, 22, 305, 118, 1195, 1205,124, 132, 1335

Basaliomas 1205Benzidine 54, 59, 66, 67T, 705, 725- blue 55, 565, 59Benzyl-mono-hydroquinone ether 7,

8T,115Biogene amine 65Biopterin 62

Blood cells 29, 30, 44, 55, 565, 58, 59,75, 76, 86, 110, 116, 119, 124, 128,1295, 130, 139, 1405, 141, 143, 144,151, 166

Blood-forming cell islets 26, 28, 34,41B-Lymphocytes 29, 43, 118, 166Bone 102, 103, 106, 109, 1635- marrow 245,26,27,28,34,41,77- resorption 131Bovine 88, 102, 103, 106, 108, 109Brain 245, 63Bursa Fabricii 26, 285, 29, 43, 77, 166- follicles 28

Caffeic acid 8TCarcinomas 120, 1215, 122, 1635, 165- lymph node metastasis 1215, 122, 165Carrageenan 96, 975, 98, 1005, 101,

102, 108, 109, 1635, 167Cartilage 88, 102, 103, 106, 1085, 109,

138, 1635Catalase 61, 71 5, 160, 161(+)-Catechine 12, 13F, 14TCatechol 7, 8T, 10F, 16, 66, 67T, 725Catecholase 4Cell-mediated immunologic defense 19,

43, 78, 80, 86, 87, 90, 91, 95, 96, 102,110, 117, 118, 119, 120, 122, 127,128, 132, 133, 137, 138, 143, 161,162, 1635, 165, 167

Cell-mediated immunologie defense,pathogenetic prinziple 1635

Cell proliferation 41, 42, 535, 112,1145, 115, 116

Cell smears 18, 195,44,56,75,765,78,124, 128, 1295, 144

Cells, argentaffin 23Cells, chromaffin 23Chicken embryo 275Chicks 26, 28Chromaffin cells 23

188 . Subject index

Chromatophoren 22Chronic diseases 1635, 168Cobefrin 8TCommon immunologic mucosal system

132, 135Concanavalin A 43, 52Connecitve tissue 4, 22, 23, 24, 25, 28,

29,33,34,44,45,63, 81, 825, 87, 96,109, 118, 120~ 12~ 137

Contact allergies 87Copper 4, 15, 63, 160Corium 21, 23, 825, 925, 94o-Cresol7Cresolase 4Cryostat sections 18, 195Crystalline body, of eosinophils 158Cutaneous basophilic hypersensitivity

87Cutis 225, 29, 81, 92, 128Cysteine 12, 13F, 14TCytochrome oxidase 30

DDC see DiethyldithiocarbamateDecarboxylase 5, 65Delayed hypersensitivity 80, 87, 895,

90,95,99, 118, 122, 127, 135, 1635Dentritic cells 22Dense bodies 158, 1595Dental caries 77Dental granulomas 131, 135, 1365, 137,

143Dental plaques 75, 765, 131Dental pulp (human) 245, 135Dental surfaces 74, 75Dentine 102, 1045, 105, 109, 135, 137,

1635Deoxyribonucleic acid 40, 41, 42, 49,

52, 103Depigmentation 11Desensitization 151Diaminobenzidine 55, 59Diethyldithiocarbamate, DDC 15, 16,

61, 62, 64 T, 66, 68T, 69Dihydroxy fumarate 645,6-Dihydroxy-indole 3F, 5Dihydroxyphenyl-alanine, dopa 3F,

55, 8T, 10F, 15, 67TDiiodotyrosine 7

Dimercaptopropanol 12, 13 F, 14T,68T

Dimethyl-phenylene diamine 12, 13F,14T, 30,725,74

Dinitrochlorobenzene, DNCB 90, 91,95,99,118,119,1635

Dinitrofluorbenzene, DNFB 90, 91,925,935,94,95, 101

2,4-Dinitrophenol 73,4-Dioxyphenyl aminoacetic acid 8TDipeptidyl peptidases 37Diphenols 11o-Diphenoldehydrogenase 4a,a-Dipyridyl 66Distributor 205DNCB see DinitrochlorobenzeneDNFB see DinitrofluorbenzeneDopachrome 3F, 5Dopa, as hydrogen donor for PER 70S,

71- dihydroxyophenyl-alanine 3F, 55,

8T,10F- melanin 35, 15- oxidase 3, 7, 8T- quinone 3F, 4, 5, 65, 59, 61Drugs 167

EDTA see Ethylendiamine-tetraacetic-acid

Endothelial cells 24Eosinophilia 33, 345Eosinophils, ingredients 160, 161Epidermis 81, 90, 92, 118, 124, 128Epididymis 245Epinephrine 8TEpithelium 75, 90, 1205, 1235, 131,

132, 1335, 135Epitheloid cells 96Erythrocytes 31, 49, 57, 74, 78, 795,

116, 130- Pseudoperoxidase 57Esterases 37, 86, 166Ethylendiamine-tetraacetic-acid, EDTA

66Ethyl-mono-hydroquinone ether 7, 115Eye 245- cells 38, 395, 40, 42, 44, 765, 1165

FCA see Freund's complete adjuvant

Fibroblasts 42, 137, 144Fibrocytes 23, 25, 137, 156S, 157Fixation 19 SFlavin enzyme 59, 60Focal diseases 167Formation of zones 96, 97S, 99, 102,

104S, 105, 106S, 108S, 109, IllS,112, 113S, 122, 127, 136S, 137, 138,163S, 164

Fowl 23, 24, 25, 28, 29, 34, 77, 90- embryonal development 26Freund's complete adjuvant, FCA 88Frozen sections 18, 19SFungi 4,5

Giant fat cells 42- cells 96, 131, 137Gingival papillae 74, 75, 132, 135- plaques 75, 76S- pockets 131Glass 102, 103, 105, 106S, 109Glucocorticoid, effect on human blood

cells 143, 144, 145S, 146S, 147, 148S,149, 150S, 151-162, 168

~-Glucuronidase 43Glutathione 12, 13F, 14TGlycoprotein 4Glycosaminoglycans 98Glycosylation 5Gonococci 73Granulation tissue 21, 77, 96, 98, 100S,

101, 102, 104S, 106S, 108S, 110,111S, 113S, 114S, 135, 136S, 137

Granulocytes 25, 34, 38, 43, 44S, 48,75, 77, 78, 87, 96, 98, 99, 135, 137,160

- basophilic 35, 55, 87- eosinophilic 30, 33, 35, 37, 38, 40, 41,

42, 44S, 45, 55, 57, 61, 75, 79, 82, 88,95, 109, 116S, 117, 123, 128, 129S,132, 144, 151, 158, 160, 161, 162,165, 166

- eosinophilic, ingredients 160, 161- eosinophilic, reversal or inversion ef-

fect 117, 158, 160- neutrophilic 30, 33, 35, 38, 40, 42, 45,

55, 57, 64, 74, 78, 79S, 87, 131, 132,144, 160, 166

Subject index . 189

Granuloma, after carrageenan 96, 97S,98, 101

- after cartilage 106, 108S- after glass 102, 103, 105, 106S, 109- after silicon dioxide, SiOl 109, 110,

111S, 112, 113S, 114S, 115, 116, 161- after xenogenic bone 106, 107S, 109- after xenogenic dentine 104S, 105,

109- formation 96, 99, 101, 102, 108, 109,

110, 111S, 112, 113S, 163SGuinea pig 34, 87, 88, 90, 91

Hair matrix 6, 91- rootse 5, 6, 81Halogens 73Heart 24SHemopoietic stem cell 28, 34, 41Heparin 160Histamin 95Histiocytes 23, 29, 96Homogentisic acid 7, 8T, 11Horseradish peroxidase 58, 63, 64 T, 66,

69,70S- as a marker enzyme 58Host tissue 82S, 83S, 84, 85S, 86, 88,

102, 133Human 5, 29, 30S, 32S, 33, 34, 46,49,

55, 56, 57, 64, 72, 87, 90, 102, 106,116, 118, 119, 128, 133, 139, 141,144, 151, 166

Humoral defense 43Hydrogen peroxide 54, 59, 60, 64, 66,

68,69, 70S, 71, 73, 74- a PO inhibitor 60Hydrolytic enzymes 43, 80Hydroquinone 7, 8T, 11 S, 72SHypochlorite (OCl-) 73 FHypotiocyanic acid 73FHypothiocyanite (OSCN-) 73 F

Immunoglobulins 43, 110, 138, 160Immunosuppression 143, 151Implantation 96,102, 105, 106, 122, 127- carrageenan 96, 97S, 98, 100S, 163 S- glass 102, 103, 105, 106S, 109- silicon dioxide, SiOl 109, 110, 111 S,

112, 113S, 114S, 115, 116Incubation 20

190 . Subject index

- instruments 205- solutions 21 TIndamine 59Indole-5,6-quinone 3FIndophenol blue method 6, 23, 30Inflammation 79, 115, 122, 131, 135,

137, 1635, 165Insects 5Intestine 7, 12, 16,245,26,44,64,655,

77, 98, 139, 1425, 144, 150,151-1625

Inversion effect 117, 158, 160Irish moss 98Isoenzymes 5Isuprel 8T

Kidney 245, 98, 128Kupffer cells 25, 34, 55, 565, 96, 128

Langerhans cells 131Lactoperoxidase-thiocyanate-peroxide-

system 73Lectins 49Leukamie 168Leukocytes 3, 4, 6, 15, 23, 33, 365, 37,

38, 40, 41, 46, 52, 55, 575, 71, 72, 74,77, 86, 88, 90, 118, 124, 128, 1295,130,139,1405,1415,143,1465,147,150,151, 162

- effect of glucocorticoid 1465, 147,1485, 1495, 1505

- isolation 35- lectin stimulation 50, 515- proliferation 42- rosette formation 46, 475Leukopenia 43Leukoplakia 1235Lichenificatio gigantea hypemophicans

77,78Lipids 73Liver 245, 26, 34, 44, 535, 55, 96, 98,

112, 1145, 115, 116, 128, 167Lung 245, 26, 44, 55, 77, 98, 128, 144,

150Lymph node 245, 25, 26, 99, 110, 118,

1195Lymphocytes 33, 35, 365, 37, 41, 42,

43, 52, 55, 575, 75, 77, 80, 88, 96,116, 131, 135, 137, 139, 143, 144

- isolation 35- lectin stimulation 50, 51 5, 535- pointlike enzyme activities 365, 37,

43, 44, 45, 46, 48, 80, 82, 86, 90, 98,141,150,166

- proliferation 116, 131, 167- rosette formation 46- transformation 49, 118, 143Lymphokine 43Lysosomen 144, 161Lysozym 71 T, 73

Macrophages 42, 55, 74, 80, 87, 96, 98,101, 109, 1165, 118, 132, 135, 165

Major basic protein 160Mast cells 23, 25, 61, 94, 96, 101, 102,

105, 106, 109, 132, 135, 1545, 1555,1565, 160

- chemotactic factors 95Megakaryocytes 55Melanin 5, 65, 11, 15,22, 23, 124, 128,

158Melanin formation 35, 4, 5, 65, 12,22,

24, 60, 128, 158- inhibitors 12Melanization 127Melanochrom 5Melanocytes 3, 4, 5, 22, 23, 24, 61, 80,

124, 12~ 12~ 131, 158, 159, 160Melanoma 4, 5, 124, 125, 1265, 127,

128, 129, 130, 158- cells 7, 124, 1265, 127, 128, 130Melanophores 81,118,1195Melanosomes 5, 158Meningococci 73Merkel cells 131Mesenterium 855, 86, 87, 167Methoxyepinephrine 7Methoxytyrosine 74-Methyl-catechol 8TMethyl-mono-hydroquinone ether 7Mice 34, 43, 55, 80, 81, 87,90Microorganisms 72, 73, 77, 96, 135,

143, 168Misletoe lectin 49, 52, 167Mitochondria formation 158Mitogens 49Mitogen, stimulation 49, 118Mitosis 115

Mixed-function oxidases 3Monocytes 35, 41, 55, 96, 98, 144Mono-hydroquinone ether 7Mononuclear cell infiltration 87, 123Mono-phenol-mono-oxygenase 4, 65Mouth rinsings 74, 75Mucosal block ,131Mucosa see oral mucosaMuscle 21, 225, 23, 245, 25, 92, 94Myelocytes 30Myeloic cells 30

a-Naphthol 30, 74Nerve cells 60Neutral nonspecific esterase 43Nevus cell tumor 124, 12553-Nitrotyrosine 7Nonspecific phenol oxidase 3, 4, 6, 7,

12, 15Noradrenaline 5, 23Nuclear particles 84Nucleic acids 73Nude mice 43, 44, 55

Oral cavity 72, 73, 74, 75, 77, 131, 139- lactoperoxidase-thiocyanate-perox-

ide-system 73, 74Oral mucosa 118,1195,1235,131,132Ovary 245Oxidase reaction in blood cells 30p-Oxyphenyl ethyl amine 8Tp-Oxy-m-methoxyphenylalanine 8Tp-Oxy-m-methoxyphenyl aminoacetic

acid 8TPancreas 245, 25Pannus 137, 1385, 143Parathyroid gland 245Paredrine 8TParedrinol8TPathogenetic principle for cell-mediated

immunologic defense responses 1635D-Penicillamine 12, 13F, 14T, 68TPeriodontal diseases 77, 135Periodontitis progressiva 123, 131,

1345, 143Peroxidase, PER 25, 158, 168- absorption spectra 69, 705- activity and effectors 64 T, 655- activity in PER and PO medium 67T

Subject index . 191

- activity in presens of PO inhibitors68T

- dihydroxy fumarate oxygen system64

- dopa as a hydrogen donor 705, 71- effect of hydrogenperoxide 69, 705- effect an proteins, aromatic amines,

phenols, aromatic acids 71 5, 72 5- halide-peroxide system 73F, 74, 161- histochemical detection 54 T- incubation solutions 19, 21- in blood cells 575- in intestine 565- in Kupffer cells 565- in macrophages 96- in saliva 73- in spleen 565- peroxide system 64- thiocyanat-peroxide system 73F, 74Peroxisomes 161PER-positive cells in mouth rinsings

and plaques 765- in oral cavity 765PER see peroxidasePhagocytes 134, 137Phagocytosis 1165, 128, 166Phagosomes 158, 1595PHA see PhytohemagglutininPhenazine 59Phenol 7, 72TPhenolase 4, 30- complex 3, 4Phenol-o-hydrolase 4Phenol oxidase, PO 2, 5, 65, 7, 8T, 9,

10, 12, 17, 54, 635- activity and effectors 64 T, 655- activity and fixation time 175- activity and pH value 175- activity and temperature 175- biological functions 168- effect of hydroquinones 115- effect of streptolysin 0 139, 1405,

141- effect on proteins, enzymes, hor-

mones 715- enzyme controls 17, 195- fixi~g 195- histochemical standard method (aera-

tion method) 15, 18, 195

192 . Subject index

- in blood cells 325, 345, 365, 385,395,475, 515,565, 128, 1295, 143

- in blood cells of melanoma patients128, 1295, 130

- incubation 20- incubation instruments 205- incubation solutions 21 T- inhibitors 2,12, 13F, 14T, 68T- inhibitors testing 14TPhenol oxidase, in Kupffer cells 565- in rosette forming cells 46, 475- leukocytal 6, 7- nomenclature 2- reaction product 6- substrate characteristics 95- substrates 8T, 9, 10F- substrate specifity 2, 15Phosphotungstic acid 158Phytohemagglutinin, PHA 43, 49, 52Pigment formation see melanin forma-

tionPlants 4, 5, 49Plasma cells 96, 110, 131, 135, 137Polyphenoloxidase 3, 4, 168PO-positive cells (POC), distribution

21PO-positive cells, effect of misletoe lec­

tin 535- electron mIcroscope examination

151-162- embryonal development 26- eye cells 38, 395, 40, 42, 44, 765,

1165- glucocorticoid-sensitive 23, 143, 144,

1455, 1465, 147, 1485, 1495, 1505,151-162

- in basalioma 1205- in bone marrow 275- in carcinoma 1215- in chicken embryo 275- in connective tissue 151-162- in delayed hypersensitivity 895, 935- in dental granulomata 1365- in eosinophilia 345PO-positive cells in granulomata- bone 106, 1075- carrageenan 96, 975, 1005, 101- cartilage 1085- dentine 1045, 105

- glass 1065- silicon 109, 1115, 1135, 1145PO-positive cells, in human blood 29,

325,33,365,385- in human epidermis 305-in human gingiva 1335- in human lymph node 1195- in human oral mucosa 1195- in human pannus tissue 1385- in intestine 255, 565- in leukoplakia 1235- in melanoma metastases 1265, 127- in mouth rinsings and plaques 765- in nevus cell tumor 1255- in normal human skin 1195- in yolk sac 275- in lung 255- in oral cavity 765- in periodontitis progressiva 1345- in pus 795- in skin 225, 245, 815- in spleen 255, 565- in the area of transplantation 825,

835, 84, 855- in the skin of a mouse 815- occurence 21, 24"5PO see PhenoloxidasePrognosis 122Protocatechuic acid 8TProtecatechuic aldehyde 8TPseudoperoxidase 57, 58Pus 77, 78Pyrocatechol 8TPyrogallol 7, 8T, 10F, 72T

o-Quinone, biological functions 168

Rabbit 175, 34Radicals 60, 73, 160Rat 4, 7, 12, 16, 17, 22, 23, 25, 34, 45,

(;4, 80, 90, 92, 98, 99, 102, 108, 139,152

Redoxpotential 4Redox system 5, 65Rejection 80, 90, 91, 925, 935, 1635Resorcin 7, 8T, 72TReticular cells 25, 41Reversal effect 117, 158

Rheumatic diseases 77, 131, 137, 139,143

Rheumatoid factor 138, 143Rosette formation 45, 46, 47S, 74, 75,

76 S, 118, 130

Saliva 73, 74, 77, 90, 131- lacto~oxidase-thiocyanate-perox-

ide-sysieW 73, 74Salivary corPuscles 74, 77, 78- glands 74- sediment 74Secretion vesicles 84Secretory immunoglobulin (sIgA) 73Sheep erythrocytes 43, 45, 74, 76, 88Sialic acid 5Silicon dioxide, Si02 109, 110, 111S,

112, 113, 114S, 115, 116, 163SSilicosis 109Singlet oxygen 73Skin 3, 4, 16, 22S, 23, 24S, 44, 55, 77,

81,87,88, 89S, 91,118, 119S, 163S- rejection 92S, 93S, 99, 163S- transplantation, xenogenic 80, 82 S,

84, 85S, 87, 88, 90,101, 163SSLO see Streptolysin 0Sodium hydrogen sulfate 12, 13F, 14TSpleen 7, 12, 16, 17S, 24S, 26, 28S, 34,

44, 53S, 55, 64, 88, 98, 101, 112,114S, 115, 116, 128, 139, 142, 144,145S, 150, 167

Splenic follicles 28S, 99, 100S, 166, 167Staphylococci 73Stratum corneum 30SStreptococci 77, 131, 135, 139, 143Streptolysin 0 52, 137, 139, 142, 143,

168Stromal cells 42Stroma reaction 123Subcutis 21, 22S, 92Sublingual gland 24SSubstantia nigra 15Sulcal fluid 74Superoxide, O 2 60- dismutase 60Suprarenal gland 23Suprarenal medulla 63Sweat 6Sweat gland cell 6

Subject index . 193

Synovial membrane 137

Teeth 102, 131Testicle 24STetrahydrofolic acid 62Tetrahydropterine 62 SThiocyanate 73Thiomersal12, 13F, 14T, 68TThiourea 12, 13F, 14T, 68TThymocyten 144Thymus 24SThyroid gland 24 STissue preparation 18, 19ST-Lymphocytes 37, 43, 44S, 45, 49,52,

75, 86, 87,90,96, 101, 118, 132, 165,166

- hydrolytic enzymes 43, 80, 86, 166- point activities 43, 44S, 86, 90, 98,

166Trachea 24STransfer of nuclear material 154S, 156S,

157Transplantation 80, 96, 102, 103, 104,

105, 106, 122, 127, 163 S- autogenic skin 84, 85S, 86- bone 106, 107S, 109- cartilage 106, 108 S- dentine 104S, 105, 109- xenogenic skin 80, 82S, 83S, 84, 85S,

87Transplant rejection 80, 90, 91, 92S,

93S, 163STryptophan 6, 8T, 160Tyramine 7, 8T, 12, 72Tyrosinase 3, 4, 5, 12, 60, 63 S, 71 S, 72,

158, 162, 168- amino acid composition 5- inhibitors 13F, 14T- leukocytal 63- melanocytal 6, 7, 8T, 9, 12, 15, 63,

158, 162- melanomal 7, 8T, 62, 162- multiple forms 5Tyrosine 3F, 4, 5, 6S, 8T, 12,23,59,

64, 66, 67T, 72, 160- ethylester 8T- hydroxylase 60S, 66- oxidase 3Tumor cells 118, 121 S, 165

194 . Subject index

Tumor metastases 118, 121S, 125, 126STumors 95, 96, 117, 122, 124- epithelial 118, 120, 121 S- immunology 117, 118- melanocytic 118, 124, 125, 126STunica propria 152

Ultraviolet radiation 128

Viruses 73, 139, 163SVitelline disks 158, 162

Xanthine oxidase 60

Yolk sac 26, 27S, 28, 34,41

Zonation 96, 97S, 99, 102, 104S, 105,106S, 108S, 109, 111S, 112, 113S,122, 127, 136S, 137, 138, 163 S, 164