Subject Index

Subject IndexSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 75, No. 12 (Dec., 1978), pp. 6341-6415Published by: National Academy of SciencesStable URL: http://www.jstor.org/stable/68962 .

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Subject Index I

JANUARY-DEC]

Introdu The terms in the Subject Index for Volt

PROCEEDINGS OF THE NATIONAL ACADE

titles, key terms, and abstracts of articles computer; numbers, conformational prefi between words are disregarded in alphabet the title of the article (or a suitable modif page number. Titles are listed in alphabel

Corrections to papers in which errors "Correction" and review articles are inde: under the index terms selected for the pap scientific names when scientific names cross-references are provided.

Because the PROCEEDINGS urges autht ommendations of the nomenclature corr proposed by the International Union of Commission on Biochemical Nomenclatu] an index that conforms with this policy. ] clature was not attempted and the index c for correct or recommended usage. In a( mendations of the commissions were neces not abbreviated even if specific recomm) missions; and in some instances, words witl tRNA is indexed as "Ribonucleic acid, ti pounds are indexed as the parent compour monophosphate is indexed as "Adenosine The "Recommended Name" from the 19' ternational Union of Pure and Applied CI Biochemistry [Enzyme Nomenclature (19 Elsevier, New York] has been used for enzy numbers were published in the papers. E( only if the EC number was printed in th< entries, e.g., "Adenosinetriphosphatase 3.6.1.3)."]

PAGINATION

Pages Issue Month

1-534 1 January 535-1044 2 February

1045-1608 3 March 1609-2054 4 April 2q55-2540 5 May 2f41-3010 6 June

6841

;o Volume 75

:MBER 1978

ction ime 75, January-December 1978, of the VY OF SCIENCES USA were chosen from T. The index terms are alphabetized by xes, Greek letters, hyphens, and spaces ization. After each index term is printed ication of the title) and the appropriate ,ica.l order under the index terms. occurred are indexed under the term Ked under the term "Review" as well as er itself. Organisms are indexed by their were provided in the papers; suitable

)rs to follow the tentative rules and rec- Lmissions (e.g., for biochemistry, those Pure and Applied Chemistry and the e), an effort has been made to construct lowever, correction of errors in nomen- hould not be looked upon as a reference Idition, some exceptions to the recom- sary. Index terms themselves are usually mdations have been made by the com- tin an index term were rearranged. (Thus, ansfer.") In general, analogues of com- d. (Thus, dibutyryl adenosine 3':5'-cyclic 3':5'-cyclic monophosphate, dibutyryl-.") '2 and 1975 recommendations of the In- iemi[stry and the International Union of 73) and Supplement 1 (1975), American mes whenever Enzyme Commission (EC) ) numbers are listed as part of the entry

paper. [Thus, some enzymes have two ' and "Adenosinetriphosphatase (EC

OF ISSUES

Pages Issue Month

3011-3536 7 July 3537-406 8 8 August 4069-4632 9 September 4633-5244 10 October 5245-5742 11 November

5743-6428 12 December



6342 Subject Index

Abelian group Colored lattices, 5264

Acantholysis Anti-epidermal-cell-surface pemphigus antibody detaches viable

epidermal cells from culture plates by activation of proteinase, 459 Acetabularia

Translation of animal virus RNA in cytoplasm of plant cell, 5557 2-Acetylaminofluorene

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives, 928

Epoxide hydrase is the preneoplastic antigen in rat liver hyperplastic nodules, 3240

Acetylcholine see also Receptor, acetylcholine Acetylcholine release from neuroblastoma X glioma hybrid cells:

Regulation, 1314 Clusters of intramembranous particles on cultured myotubes at sites that

are highly sensitive to acetylcholine, 3004 Different time course of development for high-affinity choline uptake

and choline acetyltransferase in chick retina, 2525 Muscarinic cholinergic receptors in murine lymphocytes: Demonstration

by direct binding, 2902 Myoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568 Nonequivalence of a-bungarotoxin receptors and acetylcholine receptors

in chick sympathetic neurons, 1016 Ontogenetic development of kainate neurotoxicity: Correlates with

glutamatergic innervation, 2025 Acetylcholinesterase (EC 3.1.1.7)

Histochemically distinct compartments in striatum of human, monkey, and cat demonstrated by acetylthiocholinesterase staining, 5723

Ligand-dependent conformational changes in trypsin-solubilized and in membrane particle-constrained acetylcholinesterase: Functional consequences, 3613

"Nonspecific" cholinesterase and acetylcholinesterase in rat tissues: Molecular forms, structural and catalytic properties, and significance of the two enzyme systems, 2588

Acetylchymotrypsin Deacetylation of acetylchymotrypsin: Absence of evidence for an

intermediate, 172 Acetyl-CoA:a-glucosaminide N-acetyltransferase

Sanfilippo syndrome type C: Deficiency of acetyl-CoA:a-glucosaminide N-acetyltransferase in skin fibroblasts, 5185

l-N-Acetylglucosaminidase (EC 3.2.1.30) AB variant of infantile GM2 gangliosidosis: Deficiency of factor necessary

for stimulation of hexosaminidase A-catalyzed degradation of ganglioside GM2 and glycolipid GA2, 3979

Acetylsalicylic acid see also Salicylate Fatty acid cyclooxygenase from human aorta: Sensitivity to acetylation

by aspirin, 5181 Acridine orange

RNA content in human lymphocyte subpopulations, 1938 Acrosin (EC 3.4.21.10)

Phospholipid vesicle stimulation of proacrosin activation, 149 Acrosome reaction

Stimulation of in vitro activation and the acrosome reaction of hamster spermatozoa by catecholamines, 4954

Actin Actin may be present on lymphocyte surface, 4484 Biochemistry of actomyosin-dependent cell motility (Review), 588 Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture

cells by electron microscopy and by immunofluorescence microscopy, 1820

Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate, and subfragments of myosin, 54

Mammalian cytoplasmic actins are products of at least two genes and differ in primary structure in at least 25 identified positions from skeletal muscle actins, 1106

Molecular cytochemistry: Incorporation of fluorescently labeled actin into living cells, 857

Nerve growth factor potentiates actomyosin adenosinetriphosphatase, 2210

Three-dimensional electron microscopical visualization of cytoskeleton of animal cells: Immunoferritin identification of actin- and tubulin-containing structures, 5511

a-Actinin Membrane sites in glycerinated chicken skeletal muscle fibers:

Fluorescent localization and relationship to protein composition of Z disc, 3683

Actinomycin D Actinomycin D-deoxynucleotide interactions: Binding isotherms at

benzenoid and quinoid portions of the drug, 4729 Actinomycin D inhibits initiation of DNA replication in mammalian

cells, 6088 Induction of murine erythroleukemia differentiation by actinomycin D,

2795 Action potential

Drosophila mutant with a temperature-sensitive block in nerve conduction, 4047

In vitro differentiation of a fast Na+ conductance in embryonic heart cell aggregates, 2776

Actomyosin Interaction between actomyosin and 8-substituted ATP analogs, 4229 Nerve growth factor potentiates actomyosin adenosinetriphosphatase,

2210 Adenine, erythro-9-[3-(hydroxynonyl)]

erythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpes

Proc. Natl. Acad. Sci. USA 75 (1978)

simplex virus replication in presence and absence of adenosine analogues, 4684

Adenine nucleotide Hydrolysis of poly(A) to adenine nucleotides by purified poly(A)

polymerase, 2085 Adenine nucleotide analog

Spectroscopic sensitivity of linear-benzoadenine nucleotides to divalent metal counterions, side chain conformations, micelles, and enzymes, 4204

Adenocarcinoma Inhibition of growth and guanylate cyclase activity of undifferentiated

prostate adenocarcinoma by extract of balsam pear (Momordica charantia abbreviata), 989

Adenosine Adenosine analogs inhibit adipocyte adenylate cyclase by a

GTP-dependent process: Basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis, 5362

Increased incorporation of adenosine into adenine nucleotide pools in serum-deprived mammalian cells, 1145

Adenosine analog erythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpes


Adenosine 3':5'-cyclic monophosphate, 8-azido- Cyclic nucleotide-binding proteins detected by photoaffinity labeling in

nucleus and cytoplasm of bovine liver, 5286 Adenosine 3':5'-cyclic monophosphate, dibutyryl

Acceleration of rate of elongation of tyrosine aminotransferase nascent chains by dibutyryl cyclic AMP, 140

Acetylcholine release from neuroblastoma X glioma hybrid cells: Regulation, 1314

Changes in hepatic messenger RNA for phosphoenolpyruvate carboxykinase (GTP) during development, 4189

Genetic regulation of galactokinase in Tetrahymena by cyclic AMP, glucose, and epinephrine, 1810

Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin, hydrocortisone, and dibutyryl cyclic AMP, 1418

Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells, 319

Adenosine 3':5'-cyclic monophosphate in animal cells Adenosine analogs inhibit adipocyte adenylate cyclase by a


Adenylate cyclase activation through the /-adrenergic receptor: Catecholamine-induced displacement of bound GDP by GTP, 4155

Amphibian oocyte maturation and protein synthesis: Related inhibition by cyclic AMP, theophylline, and papaverine, 1242

Calcitonin and calcium ionophores: Cyclic AMP responses in cells of a human lymphoid line, 3984

Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities, 862

Cyclic AMP-dependent protein kinases compartmentalized in human erythrocytes, 5926

Cytidine 3':5'-cyclic monophosphate phosphodiesterase activity depressed in developing tissues of guinea pigs, 4422

Depolarizing agents and cyclic nucleotides regulate phosphorylation of specific neuronal proteins in rat cerebral cortex slices, 5195

Fluorescent photoaffinity labeling: Adenosine 3':5'-cyclic monophosphate receptor sites, 1199

Monolayer formation in cultured whole pancreatic islets promoted by 3-isobutyl-1-methylxanthine, 1897

Neurotransmitter modulation, phosphodiesterase inhibitor effects, and cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200

Phosphodiesterases from bovine pineal gland: Heat-stable low molecular weight form, 3188

Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism for behavioral sensitization in Aplysia californica, 3512

Rat oocyte maturation in vitro: Relief of cyclic AMP inhibition by gonadotropins, 4369

Specific regulation by steroid hormones of amount of type I cyclic AMP-dependent protein kinase holoenzyme, 223

Temperature sensitivity of cyclic AMP production and catecholamine-induced refractoriness in a rat astrocytoma cell line, 5520

Translational control by hemin is due to binding to cyclic AMP-dependent protein kinase, 1148

Vasoactive intestinal peptide: Potent stimulator of adenosine 3':5'-cyclic monophosphate accumulation in gut carcinoma cell lines in culture, 2772

Adenosine 3':5'-cyclic monophosphate in microorganisms Positive control of Dserine deaminase synthesis in vitro, 1695

Adenosine 3':5'-cyclic monophosphate-like compound Mammalian protein kinase and phosphodiesterase activities inhibited by

a cyclic AMP-like compound isolated from higher plants, 4301 Adenosine deaminase

erythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpes simplex virus replication in presence and absence of adenosine analogues, 4684

Purine metabolism in cultured human fibroblasts from patients deficient in hypoxanthine phosphoribosyltransferase, purine nucleoside phosphorylase, or adenosine deaminase, 3722

Adenosine deaminase (EC 3.5.4.4) S-Adenosyl-L-methionine-mediated methylation required for human

monocyte chemotaxis, 3928 Deoxyadenosine triphosphate as a potentially toxic metabolite in

adenosine deaminase deficiency, 472




Gene on human chromosome 6 functions in assembly of tissue-specific adenosine deaminase isozymes, 3876

Human adenosine deaminase expressed after fusion of adenosine deaminase-deficient cells with mouse fibroblasts, 936

Purinogenic immunodeficiency diseases: Selective toxicity of deoxyribonucleosides for T cells, 5011

Residual adenosine deaminating activity in spleen of a patient with combined immunodeficiency disease and adenosine deaminase deficiency, 446

Adenosine, 3-deaza- Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A

methylation reaction essential to cytolysis, 6220 Adenosine 5'-diphosphate-ribose

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: Basis of activation of adenylate cyclase, 3050

Enzyme from rat liver that cleaves an ADP-ribosyl histone linkage, 2254 Adenosine diphosphate ribosyltransferase

Avian erythrocyte protein isolated possessing ADP-ribosyltransferase activity and capable of activating adenylate cyclase, 3621

Pseudomonas aeruginosa exoenzyme S: An adenosine diphosphate ribosyltransferase distinct from toxin A, 3211

Adenosine, etheno- Site of adenylylation of glutamine synthetase localized by electron

microscopy of enzyme-antibody complex, 5778 Adenosine kinase (EC 2.7.1.20)

Adenosine kinase initiates major route of ribavirin activation in cultured human cell line, 3042

Adenosine 5'-O-(1-thiotriphosphate) Absolute configuration of diastereomers of adenosine

5'-O-(1-thiotriphosphate): Consequences for stereochemistry of polymerization by DNA-dependent RNA polymerase from Escherichia coli, 4798

Adenosinetriphosphatase Bioenergetics and glycolysis in anaerobic Escherichia coli cells: 31p

nuclear magnetic resonance studies, 2244 Membrane moiety of the H+-ATPase complex resolved into two kinds of

subunits, 4219 Adenosinetriphosphatase (EC 3.6.1.3)

Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effects on liver surface membrane lipid structure and function, 4130

Cytoplasmic inheritance of rutamycin resistance in mouse fibroblasts, 324

Enzymatic defect in obese (ob/ob) mouse: Loss of thyroid-induced sodium- and potassium-dependent adenosinetriphosphatase, 477


Potent inhibition of dynein adenosinetriphosphatase and of motility of cilia and sperm flagella by vanadate, 2220

Sarcoplasmic reticulum Ca2+ATPase: Rotational motion, 5488 Adenosine 5'-triphosphate

Aminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by 2',3'-ribose oxidized ATP, 2088

Anti-spectrin antibody and ATP affect deformability of resealed erythrocyte membranes, 3823

ATP-dependent Ca2+ uptake into plant membrane vesicles, 1232 ATP-inauced conformational changes in restriction endonuclease from

Escherichia coli K-12, 3099 Existence of only a single functional pool of adenosine triphosphate in

human erythrocytes, 2825 Interaction between actomyosin and 8-substituted ATP analogs, 4229 Nitrogenase and nitrogenase reductase associate and dissociate with each

catalytic cycle, 2699 Stoichiometry of vectorial H+ movements coupled to electron transport

and to ATP synthesis in mitochondria, 5296 S-Adenosylmethionine

S-Adenosyl-L-methionine-mediated methylation required for human monocyte chemotaxis, 3928

Biosynthesis of cytoplasmic polyhedrosis virus mRNA: "Pretranscriptional capping", 1086

Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A methylation reaction essential to cytolysis, 6220

S-Adenosylmethionine decarboxylase (EC 4.1.1.50) Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated

decrease in ornithine and S-adenosylmethionine decarboxylase activities, 862

Adenovirus Adenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175 Evidence from UV transcription mapping in HeLa cells that

heterogeneous nuclear RNA is the messenger RNA precursor (correction), 1043

Filter-binding assay for covalent DNA-protein complexes: Adenovirus DNA-terminal protein complex, 5291

Mapping of adenovirus late promoters with nascent mercurated RNA, 1662

Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line, 5674

Nucleotide sequence at junction between coding region of adenovirus 2 hexon messenger RNA and its leader sequence, 5822

Purified simian virus 40 T antigen proteins: Biological activity, 1279 RNA-RNA splicing in vitro in adenovirus 2 mRNA formation, 5344 Temperature-sensitive replication of H5tsl25 adenovirus DNA in vitro,

4291 Transformation of rat embryo cell cultures: Interactions between

adenovirus, a tumor promoter, and chemical carcinogens, 2311 Tumor-specific transplantation antigen: Ad2+ndl hybrid virus used to

identify the protein responsible for simian virus 40 tumor rejection and its genetic origin, 3055

Subject Index 6343

Two regions of adenovirus 2 genome specify families of late polysomal RNAs containing common sequences, 625

Adenylate cyclase Adenosine analogs inhibit adipocyte adenylate cyclase by a


Adenylate cyclase activation through the ,/-adrenergic receptor: Catecholamine-induced displacement of bound GDP by GTP, 4155


Cholera toxin-activated adenylate cyclase: Reconstitution, 3113 Interaction of fluoride- and guanylyl-5'-imidodiphosphate-regulatory

proteins with adenylate cyclase, 3693 Adenylate cyclase (EC 4.6.1.1)

Adenylate cyclase activity: Regulation mediated by muscarinic acetylcholine receptors, 1788


Affinity purification of cardiac adenylate cyclase: Dependence on prior hydrophobic resolution, 59

Agonist-induced increase in apparent ,-adrenergic receptor size, 228 Cholera toxin action: Covalent modification of guanyl nucleotide-binding

protein of adenylate cyclase system, 2669 Gonadal luteinizing hormone receptors and adenylate cyclase: Transfer

of functional ovarian luteinizing hormone receptors to adrenal fasciculata cells, 4769

Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei, 1546

Parathyroid hormone- and calcitonin-activated adenylate cyclases: Development in embryonic chicken limb and in cultured cells from embryonic chicken limb, 3871

Adenylate kinase ATP-dependent Ca2+ uptake into plant membrane vesicles, 1232

Adenylate kinase (EC 2.7.4.3) Homologous genes for enolase, phosphogluconate dehydrogenase,

phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome lp, 2382

Adenylylation Site of adenylylation of glutamine synthetase localized by electron

microscopy of enzyme-antibody complex, 5778 Topographical analysis of regulatory and metal ion binding sites on

glutamine synthetase from Escherichia coli: 13C and 31p nuclear magnetic resonance and fluorescence energy transfer study, 1255

5'..Adenylyl imidodiphosphate Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,

and subfragments of myosin, 54 Adipocyte

see also Cell, fat Adenosine analogs inhibit adipocyte adenylate cyclase by a



Insulin binding to solubilized material from fat cell membranes: Evidence for two binding species, 2593

Adipogenic factor Adipose conversion of 3T3 cells depends on a serum factor, 6107

Adipose conversion Adipose conversion of 3T3 cells depends on a serum factor, 6107

Adrenalectomy Specific regulation by steroid hormones of amount of type I cyclic

AMP-dependent protein kinase holoenzyme, 223 Adrenal gland

Control of aldosterone secretion during sodium restriction: Adrenal receptor regulation and increased adrenal sensitivity to angiotensin II, 975

Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine, 1718

Adrenocorticotropic hormone see Corticotropin

Adriamycin Rescue by coenzyme Qlo from electrocardiographic abnormalities caused

by toxicity of adriamycin in rat, 5178 Aequorin

Peroxidized coelenterazine, active group in the photoprotein aequorin, 2611

Affinity filter Affinity filters, approach to isolation of tox mutants of Vibrio cholerae,

941 Affinity labeling

Cyclic nucleotide-binding proteins detected by photoaffinity labeling in nucleus and cytoplasm of bovine liver, 5286

Mitogen action: Processing of receptor induced by epidermal growth factor, 2644

Protein crosslinking and affinity labeling: High yield photoreagents, 3564 Aflatoxin B1

Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine, 4120

Principal aflatoxin B1-DNA adduct formed in vivo in rat liver: Identification, 1745

Agammaglobulinemia Restricted classes of immunoglobulin produced by lymphoid cell line

from patient with agammaglobulinemia, 2421 Agglutinin

Hemopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins, 2933

Aging see also Longevity



6344 Subject Index

Age-dependent relaxation of gene repression: Increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice, 4431

Aspartic acid racemization in heavy molecular weight crystallins and water-insoluble protein from normal human lenses and cataracts, 1204

Colony size distributions as measure of in vivo and in vitro aging, 1353 Creutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsters

with reference to clinical syndromes and strains of agent, 3432 Stuttering: High-level mistranslation in animal and bacterial cells, 1091 Xeroderma pigmentosum neurological abnormalities correlate with

colony-forming ability after ultraviolet radiation, 1984 Agrobacterium tumefaciens

DNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA topoisomerase, restriction endonuclease, and unique DNA endonuclease on plasmid and plant DNA, 4097

Proteins conferred by the virulence-specifying plasmid of Agrobacterium tumefaciens C-58, 3796

D-Alanine carboxypeptidase Depsipeptide substrate used for trapping acyl-enzyme intermediates of

penicillin-sensitive D-alanine carboxypeptidases, 84 D-Alanine carboxypeptidase IA

Escherichia coli mutant isolated lacking penicillin-sensitive D-alanine carboxypeptidase IA, 2631

Albumin see also Prealbumin; Ribonucleic acid, messenger, albumin Albumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879 Conjugation of poly-L-lysine to albumin and horseradish peroxidase:

Method of enhancing cellular uptake of proteins, 1872 Flash photolysis of human serum albumin: Characterization of indole

triplet absorption spectrum and decay at ambient temperature, 1172 Ligandin retains and albumin loses bilirubin binding capacity in liver

cytosol, 1213 Protein deficiency and energy restriction in young cebus monkeys, 1600 Spin assay for reserve bilirubin loading capacity of human serum, 1542

Alcohol dehydrogenase (EC 1.1.1.1) ADHS electromorph of Drosophila melanogaster: Structural analysis,

5609 Structural flexibility of isozyme variants: Genetic variants in Drosophila

disguised by cofactor and subunit binding, 395 Aldosterone

Aldosterone secretion regulated by the renin-angiotensin system during sodium restriction in rats, 4057


Alga Arsoniumphospholipid in algae, 4262 Photosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801 Algebra, C*

Inversion problem for singular integral operators: C*-approach, 4668 Algebraic inverse scattering method

One class of meromorphic solutions of general two-dimensional nonlinear equations, connected with algebraic inverse scattering method, 4082

Algebraic K-theory Unstable cohomology classes of SLn (Z), 43

Algebra, Lie see also Semisimple Lie group Algebraic construction and classification of Harish-Chandra modules,

1063 Lie algebras and classical partition identities, 578

Algorithm Decision procedure for indefinite hypergeometric summation, 34

Alkaline phosphatase Human placental cells transformed by tsA mutants of simian virus 40:

Model system for study of placental functions, 1409 Alkaline phosphatase (EC 3.1.3.1)

Developmental change in human intestinal alkaline phosphatase, 3909 Structure of a poly(adenosine diphosphoribose) monomer:

2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809 Allele frequency

see also Gene frequency Stepwise mutation model and distribution of allelic frequencies in a

finite population, 2868 Alloantigen

Murine Ia and human DR antigens: Homology of amino-terminal sequences, 3953

Primary structure of murine major histocompatibility complex alloantigens: Amino acid sequence studies of cyanogen bromide fragments of H-2Kb glycoprotein, 3390

Proliferative response to alloantigen amplified by factor present in extract of syngeneic thymic lymphoid cells, 4474

Selective association of murine T lymphoblastoid cell surface alloantigens with Mycoplasma hyorhinis, 4479

Thy-I differentiation alloantigen associated with synaptic complexes isolated from mouse brain, 3283

Alloreactivity Biological significance of alloreactivity: T cells stimulated by Sendai

virus-coated syngeneic cells specifically lyse allogeneic target cells, 5145

Allysine see c-Aminoadipic acid 1-semialdehyde

Alternaria solani Reaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935


Altruism Altruism: Its characteristics and evolution, 385 Model of kin selection for an altruistic trait considered as a quantitative

character, 420 Alveolar surface tension

Volume- and time-dependence of alveolar surface tension in excised lungs: Direct determination, 3417

Alveolus Linear arrays of intramembranous particles in pulmonary tubular

myelin, 6225 a-Amanitin

Mouse preimplantation embryos infected with simian virus 40 and polyoma virus, 999

Preferential transcription of ovalbumin gene in isolated hen oviduct nuclei by RNA polymerase B, 686

Temperature-sensitive RNA polymerase II mutations in Chinese hamster ovary cells, 405

Ambystoma tigrinum Responses to light of solitary rod photoreceptors isolated from tiger

salamander retina, 3507 Amerindian

Estimation of expected number of rare alleles of a locus and calculation of mutation rate, 5094

Founder effect aInd number of private polymorphisms observed in Amerindian tribes, 1904

Mutation rates in tribal Amerindians: Indirect estimates, 5585 Probability of founder effect in a tribal population, 1442

Amino acid see also Transport, amino-acid; specific amino acids

Amino-acid activation Aminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088 Amino-acid deficiency

Diet, genetics, and mental retardation interaction between phenylketonuric heterozygous mother and fetus to produce nonspecific diminution of IQ: Support of justification hypothesis, 1562

D-Amino-acid oxidase (EC 1.4.3.3) Proposed temperature-dependent conformational transition in D-amino

acid oxidase: Differential scanning microcalorimetric study, 2584 Amino acid racemization

Racemization in human lens: Rapid insolubilization of specific polypeptides in cataract formation, 3618

Amino-acid sequence see also Peptide map; Protein structure Amino acid sequence of d chain of human fibrinogen: Homology with y

chain, 1731 Amino-acid sequence of honeybee prepromelittin synthesized in vitro,

701 Amino- and carboxyl-terminal amino acid sequences of proteins coded

by gag gene of murine leukemia virus, 1404 Amino-terminal amino acid sequence of major structural polypeptides of

avian retroviruses: Sequence homology between reticuloendotheliosis virus p30 and p30s of mammalian retroviruses, 2708

Amino-terminal sequence analysis of structural proteins of Sindbis virus, 2722

Bovine protein C: Amino acid sequence of the light chain, 5889 Chromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437 Common ancestor for concanavalin A and lentil lectin? 1136 Complete amino-acid sequence of a2 heavy chain of human IgA2

immunoglobulin of A2m(2) allotype, 966 Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis, 4306 Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis (correction), 6337 Evolution of g-galactosidase, 113 Fusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737 /-Galactosidase chimeras: Primary structure of a lac

repressor-/-galactosidase protein, 4824 H-2 antigens purified from mouse liver: Structural characterization, 3322 Hemoglobin Lincoln Park: 35 fusion (anti-Lepore) variant with amino

acid deletion in 5 chain-derived segment, 1475 Insulin-like growth factor: Model for tertiary structure accounting for

immunoreactivity and receptor binding, 180 Isolation and characterization of normal crossreacting antigen: Homology

of its NH2-terminal amino acid sequence with that of carcinoembryonic antigen, 1670

Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map units, 2165

Major serine protease in rat skeletal muscle: Its mast cell origin, 5311 Mammalian cytoplasmic actins are products of at least two genes and

differ in primary structure in at least 25 identified positions from skeletal muscle actins, 1106

Mechanisms of antibody diversity: Multiple genes encode structurally related mouse K variable regions, 3913


Ovalbumin: A secreted protein without a transient hydrophobic leader sequence, 94

Penicillinase coded by Escherichia coli plasmid R6K: Partial amino acid sequence, 3732

Pre-proparathyroid hormone: Amino-acid sequence, chemical synthesis, and biological studies of precursor region, 2616

Presence of two nonidentical subunits in NAD-dependent isocitrate dehydrogenase of pig heart, 252

Primary structure of murine major histocompatibility complex alloantigens: Isolation, biochemical characterization, and preliminary alignment of CNBr fragments from H-2Kb glycoprotein, 2909





Progesterone-binding protein: Amino acid sequence, 5516 Sequence variation among heavy chains from inulin-binding myeloma

proteins, 1957 Silkmoth chorion proteins: Sequence analysis of products of a multigene

family, 390 Tyrosinase from Neurospora crassa: Amino acid sequence, 3635

Amino-acid substitution Stuttering: High-level mistranslation in animal and bacterial cells, 1091

Aminoacyl-tRNA synthetases Aminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088 Streptomycin causes misreading of natural messenger by interacting with

ribosomes after initiation, 275 a-Aminoadipic acid 6-semialdehyde

Lysyl-derived aldehydes in outer membrane proteins of Escherichia coli, 3708

'y-Aminobutyric acid see also Receptor, 'y-aminobutyric acid ~y-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310 7-Aminobutyric acid receptors: Ultrastructural localization in

mammalian central nervous system by means of [3H]muscimol binding, 2977

y-Aminobutyric acid transport modulated in nerve endings: Role of extracellular -y-aminobutyric acid and of cationic fluxes, 2981

Endogenous protein inhibitor of high affinity binding of -y-aminobutyric acid to synaptic membranes of rat brain: Purification, 4024

Ontogenetic development of kainate neurotoxicity: Correlates with glutamatergic innervation, 2025

Release of neurotransmnitters and depletion of synaptic vesicles in cerebral cortex slices by es-latrotoxin from black widow spider venom, 4016

Aminoglycoside Streptomycin causes misreading of natural messenger by interacting with

ribosomes after initiation, 275 a-Aminoisobutyric acid

Colchicine inhibits changes in amino acid transport and initiation of DNA synthesis in regenerating rat liver, 1394

Role of Na+ in a-aminoisobutyric acid uptake by membrane vesicles from mouse fibroblasts transformed by simian virus 40, 2329

Sodium-dependent amino acid transport by cultured hamster cells: Membrane vesicles retain transport changes due to glucose starvation and cycloheximide, 5048

Sodium-stimulated active transport of aminoisobutyric acid by reconstituted vesicles from partially purified plasma membranes of mouse fibroblasts transformed by simian virus 40, 3856

Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrients by quiescent BALB/C3T3 cells, 3859

6-Aminolevulinic acid Negative control of hemoglobin production in somatic cell hybrids due to

heme deficiency, 4354 Ammonia

Density-dependent regulation of growth of BSC-1 cells in cell culture: Growth inhibitors formed by the cells, 1864

Amnesia Inhibition by Z-Pro-D-Leu of development of tolerance to and physical

dependence on morphine in mice, 4573 Amphotericin B

Macrophage tumoricidal capability modulated by polyene antibiotics: Support for membrane lipid as a regulatory determinant of macrophage function, 4349

Amplification C3 convertase Autosomal locus regulates inverse relationship between sialic acid

content and capacity of mouse erythrocytes to activate human alternative complement pathway, 6078

Membrane sialic acid regulates /IH-dependent decay-dissociation of amplification C3 convertase of alternative complement pathway, 1971

Amylase Bombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139 a-Amylase (EC 3.2.1.1)

Genetic regulation of tissue-specific expression of amylase structural genes in Drosophila melanogaster, 4446

Amyloid fibril Amyloid fibril protein related to prealbumin in familial amyloidotic

polyneuropathy, 4499 Amyloidosis

Amyloid fibril protein related to prealbumin in familial amyloidotic polyineuropathy, 4499

Anabaena variabilis Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery in

heterocysts isolated from Anabaena variabilis, 6271 Analgesia

see also Anesthetic /-Endorphin-like immunoreactivity appears in human ventricular

cerebrospinal fluid upon analgesic electrical stimulation, 5170 Inhibition by Z-Pro- D-Leu of development of tolerance to and physical

dependence on morphine in mice, 4573 Anaphylatoxin

Specific C5a receptor demonstrated on intact human polymorphonuclear leukocytes, 3943

Androgen Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623

Subject Index 6345

Anemia Normal blood cells of anemic genotype in teratocarcinoma-derived

mosaic mice, 6247 Protein deficiency and energy restriction in young cebus monkeys, 1600

Anemia, sickle cell Erythrocytic mechanism of sickle cell resistance to malaria, 1994 Polymorphism of DNA sequence adjacent to human 1-globin structural

gene: Relationship to sickle mutation, 5631 Anesthetic

see also Analgesia Anesthetics and pressure: Effect on thermotropic behavior of

multilamellar dipalmitoylphosphatidylcholine liposomes, 4906 Decamethonium both opens and blocks endplate channels, 2994 Distinct protein components from Torpedo marmorata membranes carry

acetylcholine receptor site and binding site for local anesthetics and histrionicotoxin, 510

Membrane-bound neuraminidase from calf brain: Regulation of oligosialoganglioside degradation by membrane fluidity and membrane components, 122

Membrane-bound neuraminidase from calf brain: Regulation of oligosialoganglioside degradation by membrane fluidity and membrane components (correction), 4067

Volatile anesthetic facilitation of in vitro desensitization of membrane-bound acetylcholine receptor from Torpedo californica, 4563

Angiosperm Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263

Angiotensin Aldosterone secretion regulated by the renin-angiotensin system during

sodium restriction in rats, 4057 [Aspl,Ile5]- and [Phe4,Tyr8]angiotensin II: Correlation of biological

activity and solution conformation, 3630 Control of aldosterone secretion during sodium restriction: Adrenal

receptor regulation and increased adrenal sensitivity to angiotensin II, 975

Renovascular hypertension reversed by antibodies specific for angiotensin-converting enzyme, 5702

Angiotensin-converting enzyme see Peptidyl dipeptidase

Anion Role of anions in parathyroid hormone release from dispersed bovine

parathyroid cells, 876 Anisole

Variation of isomer distribution in electrophilic nitration of toluene, anisole, and o-xylene: Independence of high regioselectivity from reactivity of reagent, 545

Antheraea polyphemus Silkmoth chorion proteins: Sequence analysis of products of a multigene

family, 390 Antibiotic

see also specific antibiotics Mutagenesis of a circular DNA molecule in vitro by using synthetic

restriction sites, 6012 Antibiotic, polyene


Antibiotic resistance "Conjugal" transfer of plasmid DNA among oral streptococci, 3484 Induced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479 Antibody

Adult murine T cells activated in vitro by (v-fetoprotein and naturally occurring T cells in newborn mice: Identity in function and cell surface differentiation antigens, 2897

Antibodies against human melanoma produced by somatic cell hybrids, 3405

Antibody response of mice to chemically induced tumors, 955 Anti-idiotypic antibodies used as cell-surface receptor probes, 2443 Anti-spectrin antibody and ATP affect deformability of resealed

erythrocyte membranes, 3823 Blocking of primary in vitro antibody responses to thymus-independent

and thymus-dependent antigens with antiserum specific for IgM or IgD, 432

Colonic tissue-bound antibodies: Isolation and characterization from patients with idiopathic ulcerative colitis, 4528

Combined immunofluorescence and high-voltage electron microscopy of cultured mammalian cells, using an antibody that binds to glutaraldehyde-treated tubulin, 334

Control of antibody heterogeneity in strain 2 guinea pigs, 959 Control of proliferation and differentiation in B lymphocytes by anti-Ig

antibodies and a serum-derived cofactor, 2401 Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture


Hapten mimic elicits antibodies recognizing prostaglandin E2, 2689 Human antibodies reactive with purified envelope antigens of primate

type C tumor viruses, 5692 Idiotypic analysis of antibodies to poly(Glu6?Ala3eTyrl?): Interstrain and

interspecies idiotypic crossreactions, 6192 Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679 Inhibition of dual lr gene-controlled T-lymphocyte proliferative response

to poly(Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion, 2387

Leukemia in AKR mice: Defined suppressor cell population expressing membrane-associated DNA, 6211




6346 Subject Index

n-Melanocyte stimulating hormone: Immunohistochemical identification and mapping in neurons of rat brain, 6300

Monoclonal antibodies against rabies virus produced by somatic cell hybridization: Detection of antigenic variants, 3938

Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1), 5565

Monovalent antibodies against MM-creatine kinase remove M line from myofibrils, 4296

Monovalent antibodies directed to transformation-sensitive membrane components inhibit viral transformation, 6049

Myasthenic patients' immunoglobulin affects acetylcholine receptor turnover: Selectivity of degradation process, 3422

Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus, 3965

"Panning" for lymphocytes: Method for cell selection, 2844 Receptor crosslinking or aggregation is important in insulin action, 4209 Regulation of antibody heterogeneity by suppressor T cells: Diminishing

suppressor T cell activity increases number of dinitrophenyl clones in mice immunized with dinitrophenyl-poly(Glu,Lys,Phe) or dinitrophenyl-poly(Glu,Lys,Ala), 2914

Repertoire of antiviral antibodies expressed by somatic cell hybrids, 1510 Site of adenylylation of glutamine synthetase localized by electron

microscopy of enzyme-antibody complex, 5778 Specific antibody and Clq binding to hapten-sensitized lipid vesicles

visualized, 3933 Specific antibody-dependent binding of complement component Clq to

hapten-sensitized lipid vesicles, 1515 Specific immunosuppression of experimental autoimmune myasthenia

gravis by denatured acetylcholine receptor, 4006 Specificity and crossreactivity of idiotypes of murine antibodies induced

by poly(Tyr,Glu)-poly(DLAla)-poly(Lys) and poly(Phe,Glu)-poly(DLAla)-poly(Lys), 5118

Type C RNA virus-specific antibody in human systemic lupus erythematosus demonstrated by enzymoimmunoassay, 2463

Ultrastructural antibody localization of a2-macroglobulin in membrane-limited vesicles in cultured cells, 4359

Yeast fatty acid synthetase subunits: Three-dimensional model of the enzyme, 5792

Antibody, activating Antibody-mediated activation of defective 3-D-galactosidase: Dimeric

form of activatable mutant enzyme, 720 Antibody, cytotoxic

Tumor cells: Time-dependent resistance or susceptibility to cytotoxic antibody after exposure to chemotherapeutic agent, 6202

Antibody precursor Antigen-induced antibody biosynthesis from antibody precursors, the

heavy and light immunoglobulin chains, 2434 Anticoagulant

Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by glucocorticoids, 5506

Antigen see also Alloantigen

Antigen, blood group Self-nonself concept for cancer and diseases previously known as

"autoimmune" diseases, 5697 Two HLA-linked loci controlling the fourth component of human

complement, 5165 Antigen, cancer

Detection in human breast carcinomas of antigen immunologically related to a group-specific antigen of mouse mammary tumor virus, 1529

Antigen, carcinoembryonic Isolation and characterization of normal crossreacting antigen: Homology


Antigen, cell surface see also Cell surface; Receptor, cell-surface Abelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918 Cell surface antigens of malignant human brain tumors: Serological

analysis, 5122 Molecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674 Myeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901 "Panning" for lymphocytes: Method for cell selection, 2844 Periodic loss of reactivity of a myeloma tumor with cytotoxic

thymus-derived lymphocytes, 441 THY-1: Differentiation marker of potential mammary myoepithelial cells

in vitro, 6093 Tumor cells: Time-dependent resistance or susceptibility to cytotoxic

antibody after exposure to chemotherapeutic agent, 6202 Tumor cell surface antigen from spontaneously transformecl BALB/c

mouse fibroblasts: Isolation and characterization, 5912 Antigen, cell surface differentiation

Adult murine T cells activated in vitro by '-fetoprotein and naturally occurring T cells in newborn mice: Identity in function and cell surface differentiation antigens, 2897

Antigen, differentiation Ia-like antigens: Expression on cultured human malignant melanoma cell

lines, 6235 Antigen, e

Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: Nonidentity of e antigen with immunoglobulins, 1952

Antigen, envelope Human antibodies reactive with purified envelope antigens of primate

type C tumor viruses, 5692


Antigen, feline oncornavirus-associated cell membrane Feline sarcoma virus-coded antigen (FOCMA-S): Characterization by

radioimmunoassay, 4489 Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein

with feline oncornavirus-associated cell membrane antigen (FOCMA) activity, 1505

Antigen, Forssman Self-nonself concept for cancer and diseases previously known as

"autoimmune" diseases, 5697 Antigen, group-specific


Antigen, herpes simplex-related Binding to chromosomes of herpes simplex-related antigens in

biochemically transformed cells, 3288 Antigen, histocompatibility

see also Histocompatibility; Major histocompatibility complex H-2.28, an alloantigenic marker allelic to H-2.1, is expressed on all three

known types of H-2 molecules, 4441 H-2 antigens purified from mouse liver: Structural characterization, 3322 Histocompatibility antigens participate in capping of molecularly

independent cell surface components by their specific antibodies, 2406 HLA antigen-containing liposomes: Binding to bacteria, 6197 Human (HLA-A and HLA-B) and murine (H-2K and H-2D)

histocompatibility antigens are cell surface receptors for Semliki Forest virus, 3846

/2-Microglobulin and HLA antigens: Enhanced expression on human lymphoid cells by interferon, 6215

Phosphorylation in vivo and in vitro of human histocompatibility antigens (HLA-A and HLA-B) in carboxy-terminal intracellular domnain, 6002

Reconstitution of purified detergent-soluble HLA-A and HLA-B antigens into phospholipid vesicles, 3230

Secondary cytotoxic T lymphocytes induced by purified HLA-A and HLA-B antigens reconstituted into phospholipid vesicles, 5688

Selective association of murine T lymphoblastoid cell surface alloantigens with Mycoplasma hyorhinis, 4479

Antigen, Ia Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response


Antigen, Ia-like Ia-like antigens: Expression on cultured human malignant melanoma cell

lines, 6235 Antigenic variation

Biochemical evidence that "new" influenza virus strains in nature may arise by recombination (reassortment), 3341

Antigen, killer cell Activated human T lymphocytes display new surface glycoproteins, 3455

Antigen, M Streptococcal M protein: Repeating covalent structure, 3163

Antigen, M-N Structural polymorphism within amino-terminal region of MM, NN, and

MN glycoproteins (glycophorins) of human erythrocyte membrane, 2727

Antigen, normal crossreacting Isolation and characterization of normal crossreacting antigen: Homology


Antigen, nuclear Epstein-Barr virus and human chromosomes: Close association of

resident viral genome and expression of virus-determined nuclear antigen (EBNA) with presence of chromosome 14 in human-mouse hybrid cells, 5155

Nuclear antigens in Novikoff hepatoma: Purification, 1943 Antigen, preneoplastic


Antigen, stage-specific embryonic Monoclonal antibody defining a stage-specific mouse embryonic antigen

(SSEA-1), 5565 Antigen, synthetic polypeptide

Specificity and crossreactivity of idiotypes of murine antibodies induced by poly(Tyr,Glu)-poly(DLAla)-poly(Lys) and poly(Phe,Glu)-poly(DLAla)-poly(Lys), 5118

Antigen, T see Antigen, tumor

Antigen, thymus-dependent Blockintg of primary in vitro antibody responses to thymus-independent


Antigen, transplantation Molecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674 Antigen, trophoblast membrane

Antigens of human trophoblasts: Role in normal and abnormal pregnancies, 1947

Antigen, tumor Abelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918 Chromosomal assignment for a simian virus 40 integration site in human

cells, 4460 DNAs of simian virus 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073 Expression of simian virus 40 early genes in transformed rat cells is

correlated with maintenance of transformed phenotype, 4987




Feline sarcoma virus-coded antigen (FOCMA-S): Characterization by radioimmunoassay, 4489

Isolation of stable rat sarcoma viruses in vitro, 2972 Large and small tumor antigens from simian virus 40 have identical

amino termini mapping at 0.65 map units, 2165 Mouse preimplantation embryos infected with simian virus 40 and

polyoma virus, 999 New region of simian virus 40 genome required for efficient viral

transformation, 2473 Nucleotide sequence of simian virus 40 small-t gene, 2160 Polyoma virus T antigens translated in vitro, 5917 Primate papovavirus tumor antigens: Common methionine-tryptic

peptides near amino-terminal end, 1131 Purified simian virus 40 T antigen proteins: Biological activity, 1279 Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320 Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647 Tumor antigens enhance tumor growth in vivo by interacting with a

radiosensitive (suppressor?) cell population, 436 Tumor antigen(s) in cells productively infected by wild-type polyoma

virus and mutant NG-18, 79 Tumor cell surface antigen from spontaneously transformed BALB/c

mouse fibroblasts: Isolation and characterization, 5912 Viable deletion mutants in simian virus 40 early region, 4455 Viral proteins in mouse mammary tumors detected by

immunoperoxidase staining of paraffin sections, 1524 Antigen, tumor-specific

Lymphoblastoid cell lines from patients with chronic lymphocytic leukemia: Identification of tumor origin by idiotypic analysis, 5706

Antigen, tumor-specific transplantation Antibody response of mice to chemically induced tumors, 955 Tumor-specific transplantation antigen: Ad2+ndl hybrid virus used to


Antigen, V Mouse preimplantation embryos infected with simian virus 40 and

polyoma virus, 999 Antigen, variant-specific surface

Crossreacting determinants in variant-specific surface antigens of African trypanosomes, 1989

Antihistamine Histamine H1- and H2-receptor antagonists: Beneficial and detrimental

actions in circulatory shock, 2941 Histamine H1 receptors identified in mammalian brain membranes with

[3H]mepyramine, 6290 Antimonial compound

Therapy of leishmaniasis: Superior efficacies of liposome-encapsulated drugs, 2959

Antimycin A Cytoplasmic transfer of resistance to antimycin A in Chinese hamster

cells, 5604 Antipain

Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate synthetase I in tadpole liver, 5339

Aotus Immunization against malaria with antigen from Plasmodium

falciparum cultivated in vitro, 5665 Aotus trivirgatus

Endogenous New World primate type C viruses isolated from owl monkey (Aotus trivirgatus) kidney cell line, 1004

Aplysia Neuronal interaction mediated by behaviorally active peptide, 5732

Aplysia californica Neurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200 Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512 Apolipoprotein

Human serum cholesteryl ester transfer protein: Isolation and characterization, 3445

Solubilization of apolipoprotein B and its specific binding by cellular receptor for low density lipoprotein (correction), 1043

Apomorphine Multiple receptors for brain dopamine, 1153

Arachidonate lonophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Arbacia punctulata

Attack of sea urchin eggs by dogfish phagocytes: Model of phagocyte-mediated cellular cytotoxicity, 1825

Area dentata -y-Aminobutyric acid receptors: Quantitative visualization in

hippocampus and area dentata demonstrated by [3H]muscimol autoradiography, 2516

Argininosuccinate lyase (EC 4.3.2.1) Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene to

pter - q22 region of human chromosome 7 by bioautography, 6159 Argininosuccinic aciduria

Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene to pter -- q22 region of human chromosome 7 by bioautography, 6159

Aromatic compound Iron, an essential element for biosynthesis of aromatic compounds, 4810

Arrhenius graph RNA transport from isolated rat liver nuclei: Activation energy, 5400

Arsenic Arsoniumphospholipid in algae, 4262

Subject Index 6347

Arsoniumphospholipid Arsoniumphospholipid in algae, 4262

Artemia salina Artemia salina and Escherichia coli ribosome structure compared by

electron microscopy, 2829 Artery

Arterial collagen: Increased turnover in hypertensive rats, 451 Arthritis, juvenile rheumatoid

Loss of human supressor cells during active autoimmune disease, 5150 Ascaris lumbricoides

Motoneurons of the nematode Ascaris: Structure and physiological activity, 3493

Ascorbic acid Experimental studies designed to evaluate management of patients with

incurable cancer, 4543 Experimental studies designed to evaluate management of patients with

incurable cancer, 6252 Fluorescent light-induced chromosome damage and its prevention in

mouse cells in culture, 1830 Supplemental ascorbate in supportive treatment of cancer: Reevaluation

of prolongation of survival times in terminal human cancer, 4538 Aspartate aminotransferase (EC 2.6.1.1)

Deficiency of vitamin B6 in carpal tunnel syndrome: Biochemical evidence based on a crossover clinical study, 3410

Syncatalytic conformational changes in aspartate aminotransferase determined by hydrogen-deuterium exchange, 145

Aspartate carbamoyltransferase (EC 2.1.3.2) Cooperativity eliminated in aspartate transcarbamylase by nitration of

single tyrosine residue, 2654 Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276 Aspartate kinase (EC 2.7.2.4)

Refolding of a bifunctional enzyme and its monofunctional fragment, 5979

Aspartate transcarbamylase see Aspartate carbamoyltransferase

Aspartic acid L-Aspartate: A role in cone photoreceptor synaptic transmission in carp

retina, 5205 Aspartic acid racemization in heavy molecular weight crystallins and

water-insoluble protein from normal human lenses and cataracts, 1204 Racemization in human lens: Rapid insolubilization of specific

polypeptides in cataract formation, 3618 Aspartokinase II-homoserine dehydrogenase II


Aspirin see Acetylsalicylic acid

Association constant Paired ions: Dipolar pairs as subset of diffusion pairs, 16

Astrocytoma Cell surface antigens of malignant human brain tumors: Serological

analysis, 5122 Temperature sensitivity of cyclic AMP production and

catecholamine-induced refractoriness in a rat astrocytoma cell line, 5520

Astronomy Stability in dynamical astronomy, 5743

Asymmetric displacement current Asymmetric displacement currents in giant axons and macromolecular

gating processes, 4911 Asymptotic representation

Asymptotic representation of conformal maps of strip domains without boundary regularity, 2082

Atherosclerosis Cholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877 Atomic absorption spectrum

Iron, an essential element for biosynthesis of aromatic compounds, 4810 Atropine

Muscarinic cholinergic receptors in murine lymphocytes: Demonstration by direct binding, 2902

Auditory nerve fiber Synapses involving auditory nerve fibers in primate cochlea, 4582

Autoimmune disease Failure of autologous mixed lymphocyte reactions between T and non-T

cells in patients with systemic lupus erythematosus, 3464 Loss of human supressor cells during active autoimmune disease, 5150 Self-nonself concept for cancer and diseases previously known as

"autoimmune" diseases, 5697 Autoimmunity


Imnmunologic function and renal disease in (NZB X NZW)F1 mice: Influence of dietary restriction, 1500

Myasthenic patients' immunoglobulin affects acetylcholine receptor turnover: Selectivity of degradation process, 3422

Autoinhibitory factor Production of autoinhibitory factors by mouse lymphoma cells in vitro

and its relationship to thiol dependence, 1849 Autophagy

Endoplasmic reticulum and autophagy in rat hepatocytes, 5039 Autoradiography

Altered pattern of replication of human chromosomes in a human fibroblast-mouse cell hybrid, 1470

y-Aminobutyric acid: Neurotransmitter candidate for cone horizontal cells of catfish retina, 6310



6348 Subject Index

y-Aminobutyric acid receptors: Autoradiographic localization in rat central nervous systemn by using [3H]muscimol, 1024

y-Aminobutyric acid receptors: Quantitative visualization in hippocampus and area dentata demonstrated by [3H]muscimol autoradiography, 2516

3y-Aminobutyric acid receptors: Ultrastructural localization in mammalian central nervous system by means of [3H]muscimol binding, 2977

-y-Aminobutyric acid receptors visualized in spinal cord cultures by [3H]muscimol autoradiography, 6281

Base ratio, DNA content, and quinacrine-brightness of human chromosomes, 3382

Epidermal growth factor: Morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts, 5025

Immunological screening method to detect specific translation products, 2746

Incomplete dosage compensation in evolving Drosophila sex chromosome, 931

Replica plating and in situ emnzymatic assay of animal cell colonies established on filter paper, 1190

Serotonin and substance P coexist in neurons of rat's central nervous system, 1582

Auxotroph Replica plating and in situ enzymatic assay of animal cell colonies

established on filter paper, 1190 Avian erythroblastosis virus

Post-transcriptional suppression of globin gene expression in cells transformed by avian erythroblastosis virus, 3776

Axon Asymmetric displacement currents in giant axons and macromolecular

gating processes, 4911 Cole-Moore effect in the frog node, 3254 Electrophysiological analysis of reinnervation of transplants in anterior

chamber of eye by autonomic ground plexus of iris, 1009 Olfactory axons and synapse formation regenerated in forebrain after

bulbectomy in neonatal mice, 5230 Subcellular fractionation of intra-axonally transported polypeptides in

rabbit visual system, 505 8-Azaguanine

Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker, 410

Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium, 4465

Azathioprine Thymic hormone-like restoration by human prealbumin of azathioprine

sensitivity of spleen cells from thymectomized mice, 823 Azo dye

Azo dyes prevent hydrocarbon-induced leukemia in rat, 4524 Azurin

Blue copper site in oxidized azurin characterized by extended x-ray absorption fine structure: Determination of a short Cu--S distance, 4069

Baboon see Papio cynocephalus

Bacillus Calmette-Guerin Systemic bacillus Calmette-Guerin (BCG) activates natural suppressor

cells, 5142 Bacillus megaterium

Membrane lateral phase separations and chlortetracycline transport by Bacillus megaterium, 1319

Bacillus stearothermophilus Translational specificity of Bacillus stearoth ermophilus ribosomes, 167

Bacillus subtilis Construction and properties of chimeric plasmids in Bacillus subtilis,

1428 DNA cloning in Bacillus subtilis, 1433 Helical Bacillus subtilis macrofibers: Morphogenesis of bacterial

multicellular macroorganism, 2478 Mechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664 Molecular cloning of genetically active fragments of Bacillus DNA in

Bacillus subtilis and properties of vector plasmid pUBlO, 1423 Secreted nascent chains: Interaction with surrounding membrane in

Bacillus subtilis, 5922 Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993 T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045 Two thymidylate synthetases in Bacillus subtilis, 1194 Uracil incorporation into nascent DNA of thymine-requiring mutant of

Bacillus subtilis 168, 2195 Bacteremia

Haemophilus influenzae bacteremia and meningitis resulting from survival of a single organism, 1534

Bacterial conjugation Cell-cell interactions in conjugating Escherichia coli: Purification of F

pili with biological activity, 1237 Fertility repression of F-like conjugative plasmids: Physical mapping of

R6-5 finO and finP cistrons and identification of finO protein, 5836 Bacterial multicellular macroorganism

Helical Bacillus subtilis macrofibers: Morphogenesis of bacterial multicellular macroorganism, 2478

Bacteriochlorophyll Bacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920 Nitrogen electron nuclear double resonance and proton triple resonance

experiments on bacteriochlorophyll cation in solution, 2296


Bacteriophage see also Deoxyribonucleic acid, bacteriophage; Prophage; Receptor,

bacteriophage; Repressor, bacteriophage Antagonists of DNA gyrase inhibit repair and recombination of

UV-irradiated phage X, 4125 Bacteriophage X carrying the Escherichia coli chromosomal region of

replication origin, 5099 Bacteriophage X repressor: Interaction with nonoperator DNA containing

single-strand gaps, 5817 Chromosomal integration of phage X by a DNA insertion element, 1490 Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367 Cosmids: Type of plasmid gene-cloning vector packageable in vitro in

bacteriophage X heads, 4242 cro protein of bacteriophage X: Mechanism of action, 1783 Discrete length classes of DNA depend on mode of dehydration, 710 Enzymatic breakage of cohesive end site of phage X DNA: Terminase

(ter) reaction, 4199 Identification of host protein necessary for bacteriophage morphogenesis

(groE gene product), 131 Immunological screening method to detect specific translatioi products,

2746 Intracellular development of bacteriophage X, with special reference to

DNA packaging, 3206 Inverted repeated DNA from Chinese hamster ovary cells studied with

cloned DNA fragments, 2679 Mutations altering cellular localization of phage X receptor, an

Escherichia coli outer membrane protein, 5802 N gene protein of bacteriophage X identified, 2225 Role of the host in virus assembly: Cloning of Escherichia coli groE gene

and identification of its protein product, 136 Single base-pair change creates a Chi recombinational hotspot in

bacteriophage X, 96182 Structure of X att sites generated by int-dependent deletions, 5437 Symmetry mismatch and DNA packaging in large bacteriophages, 4779

Bacteriophage fX Analysis of (pX DNA replication cycle by electron microscopy, 605

Bacteriophage 4X174 Efficient correction of a mutation by use of chemically synthesized DNA,

4268 Escherichia coli plasmid bearing functional gene G of bacteriophage

qX1.74: Construction and characterization, 774 Mutagenesis during in vitro DNA synthesis, 1924 Nucleotide specificity in DNA scission by neocarzinostatin, 3603

Bacteriophage OXsB1 Recognition site of Escherichia coli B restriction enzyme on qXsB1 and

simian virus 40 DNAs: Interrupted sequence, 2271 Bacteriophage fl

Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: Endoproteolytic cleavage of nascent fl pre-coat protein, 361

nucleotide sequence of recognition site for restriction-modification enzyme of Escherichia coli B, 2266

Bacteriophage fd RNA transcribed from DNA at origin of phage fd single strand to

replicative form conversion, 645 Structure of origin of DNA replication of bacteriophage fd, 50

Bacteriophage G4 Nucleotide sequences of separate origins of synthesis of bacteriophage

G4 viral and complementary DNA strands, 1081 Site-specific initiation of a DNA fragment, 1652 Site-specific initiation of a DNA fragment: Nucleotide sequence of

bacteriophage G4 negative-strand initiation site, 3094 Site-specific initiation of a DNA fragment: Nucleotide sequence of

bacteriophage G4 negative-strand initiation site (correction), 6337 Bacteriophage M13

Interaction of oligonucleotides with gene-5 protein of bacteriophage M13: Photochemically induced dynamic nuclear polarization study, 5281

Structure of nascent replicative form DNA of coliphage M13, 153 Synthesis of phage M13 coat protein and its assembly into membranes in

vitro, 1754 Bacteriophage Mu

Phage Mu-i integration: Nalidixic acid treatment causes clustering of Mu-l-induced mutations near replication origin, 4940

Bacteriophage N4 Template requirements of N4 virion RNA polymerase, 3220

Bacteriophage P1 Bacteriophage PI immunity analyzed by using X-PI recombinants

constructed in vitro, 5594 Bacteriophage P2

Strand-specific break near origin of bacteriophage P2 DNA replication, 1685

Bacteriophage P4 Construction of plasmid-phage hybrid: Use of hybrid to demonstrate

ColEl DNA replication in vivo in absence of ColEl-specified protein, 2200

Determination of capsid size by satellite bacteriophage P4, 400 Bacteriophage Q/I replicase

RNA sequencing with radioactive chain-terminating ribonucleotides, 5334

Bacteriophage SPO1 Promoter recognition by phage SPOl-modified RNA polymerase, 1185

Bacteriophage T4 Kinetic factors and form determination of head of bacteriophage T4,

4165 Method to assess similarity of protein structures, with applications to T4

bacteriophage lysozyme, 2180 Mononucleotides added to oligoribonucleotide acceptors with T4 RNA

ligase, 1270




Phage T4 endonuclease V stimulates DNA repair replication in isolated nuclei from ultraviolet-irradiated human cells, including xeroderma pigmentosum fibroblasts, 2598

Thioredoxin induced by bacteriophage T4: Three-dimensional structure, 5827

Bacteriophage T7 Bacteriophage T7 DNA: Marker rescue and partial replication, 6144 Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741 Depurinated DNA repaired in vitro by enzymes purified from human

lymphoblasts, 794 Discrete length classes of DNA depend on mode of dehydration, 710 Genetic recombination and complementation between bacteriophage T7

and cloned fragments of T7 DNA, 2276 Regulation of transcription of late genes of bacteriophage T7, 804

Bacteriorhodopsin see also Rhodopsin Bacteriorhodopsin: Molecular orientation within the purple membrane of

Halobacterium halobium, 4320 Charge stabilization mechanism in visual and purple membrane

pigments, 2558 Molecular mechanism of excitation in visual transduction and

bacteriorhodopsin, 549 Secondary protein-chromophore interactions at Schiff base linkage in

bacteriorhodopsin: Molecular mechanism for proton pumping, 4642 Balsam pear

see Momordica charantia abbreviata Barium

Opposing effects of calcium and barium in vertebrate rod photoreceptors, 1587

Barley Rhynchosporoside, a host-selective toxin produced by Rhynchosporium

secalis, the causal agent of scald disease of barley, 4339 Baroreceptor reflex

Differential sympathetic discharges in chemoreceptor reflexes, 5239 Base pair

How many base-pairs per turn does DNA have in solution and in chromatin? Theoretical calculations, 640

Physical basis for ambiguity in genetic coding interactions, 610 Batrachotoxin

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218 Behavior

Alternative mating strategies in digger wasp Philanthus zebratus Cresson, 1901

Conditioned behavior of rats modified by neurohypophyseal hormones and analogues, 2493

Inversion of a behavioral response in bacterial chemotaxis: Explanation - at molecular level, 4150 Kin selection: A classical approach and a general solution, 6154 K+-resistant mutants and "adaptation" in Paramecium, 5645 Law of perceptual stability: Abstract foundations, 2049 Law of perceptual stability: Well-definedness and validity, 2535 Model of kin selection for an altruistic trait considered as a quantitative

character, 420 Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512 Beneckea harveyi

Myristic acid stimulation of bacterial bioluminescence in "aldehyde" mutants, 266

Benz[alanthracene Azo dyes prevent hydrocarbon-induced leukemia in rat, 4524

Benz[a]anthracene, dimethyl- Four trans-3,4-dihydrodiol metabolites of

7,12-dimethylbenz[ajanthracene and their in vitro DNA-binding activities upon further metabolism, 5466

Neoplastic transformation of rat mammary cells exposed to 7,12-dimethylbenz[a]anthracene or N-nitrosomethylurea in cell culture, 3836

Benzene Electrophilic and free radical nitration of benzene and toluene with

various nitrating agents, 1045 Linear-benzoadenine nucleotide


Benzo[a]pyrene Human bronchus-mediated mutagenesis of mammalian cells by

carcinogenic polynuclear aromatic hydrocarbons, 2003 Modification of DNA by the benz[a]pyrene metabolite diol-epoxide

r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 415 Regio- and stereoselectivity of various forms of purified cytochrome

P-450 in metabolism in benzo[alpyrene and (-)-trans-7,8-dihydroxy-7,8-dihydroxybenzo[a]pyrene as shown by product formation and binding to DNA, 3123

Tumorigenicity of optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptional activity of (+)-7/i,8C-dihydroxy-9Cs,1Oa-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene, 5358

Benzodiazepine Benzodiazepine binding: Competitive inhibition by fractions from

porcine brain, 6319 Bicuculline methochloride

'y-Aminobutyric acid: Neurotransmitter candidate for cone horizontal cells of catfish retina, 6310

Bile Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effects

on liver surface membrane lipid structure and function, 4130

Subject Index 6349

Cholesterol monohydrate growth in model bile solutions, 6230 Lipoprotein-X: Secretion by perfused livers of rats with cholestasis, 3459

Bilirubin Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer of

microsomal mixed-function monooxygenases, 682 Ligandin retains and albumin loses bilirubin binding capacity in liver

cytosol, 1213 Spin assay for reserve bilirubin loading capacity of human serum, 1542

Bilirubin-UDPglucuronate transferase Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer of

microsomal mixed-function monooxygenases, 682 Bindin

Egg surface glycoprotein receptor for sea urchin sperm bindin, 881 Binomial coefficient identity

Decision procedure for indefinite hypergeometric summation, 34 Bioautography

Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene to pter -? q22 region of human chromosome 7 by bioautography, 6159

Bioenergetics Geometric model describing quasi-equilibrium of energy flow in

populations of' stream insects, 381 Bioluminescence

see also Chemiluminescence; Luminescence Bacterial bioluminescence: Isolation of in vivo emitter, 833 Bioluminescence of firefly: Key steps in formation of electronically

excited state for model systems, 30 Myristic acid stimulation of bacterial bioluminescence in "aldehyde"

mutants, 266 Peroxidized coelenterazine, active group in the photoprotein aequorin,

2611 Biopolymer

Molecular field theory of reversible unfolding of biopolymers, 2755 BIK virus

BK virus DNA: Cleavage map and sequence analysis, 2150 Human tumors and human malignant cell lines analyzed for BK

virus-specific DNA sequences, 454 Minichromosome from BK virus as template for transcription in vitro,

1126 Primate papovavirus tumor antigens: Common methionine-tryptic

peptides near amino-terminal end, 1131 Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320 Bladder, urinary

Energetics of sodium transport in toad urinary bladder, 4591 Blastokinin

see Uteroglobin Bleomycin

Bleomycin: Interaction with DNA, 5983 Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608 Blood-brain barrier

Isolated microvessels: Blood-brain barrier in vitro, 4544 Blood coagulation

see also specific factors Bovine protein C: Amino acid sequence of the light chain, 5889 Factor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539 Blood group

see Antigen, blood group Blood pressure

see also Hypertension Systemic administration of f-endorphin: Potent hypotensive effect

involving a serotonergic pathway, 6240 Blood transfusion

Separation of younger red cells with improved survival in vivo: Approach to chronic transfusion therapy, 3474

Body temperature Comparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food, 1577 Comparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food (correction), 3535 Bombesin

Bombesin and litorin interact with specific membrane receptors on pancreatic acinar cells, 6139

Bombesin: Specific binding to rat brain membranes, 5372 Bombyx mori

Precursor molecules to individual tRNA species from Bombyx mori identified, 635

Bond angle Bond angles in transition metal tetracarbonyl compounds: Test of theory

of hybrid bond orbitals, 569 Bone

Calcification of isolated matrix vesicles and reconstituted vesicles from fetal bovine cartilage, 3805

Parathyroid hormone- and calcitonin-activated adenylate cyclases: Development in embryonic chicken limb and in cultured cells from embryonic chicken limb, 3871

Borate Serine-borate complex as transition-state inhibitor of -y-glutamyl

transpeptidase, 4806 Borel-Serre compactification

Unstable cohomology classes of SLn (Z), 43 Boric acid gel

ADP-ribosylated nuclear proteins: Purification by covalent chromatography on dihydroxyboryl polyacrylamide beads and characterization, 1111



6350 Subject Index

Boundary behavior Asymptotic representation of conformal maps of strip domains without

boundary regularity, 2082 Boundary Laplacian

Local analytic hypoellipticity for ?fib on nondegenerate Cauchy-Riemann manifolds, 3027

Bounded variation Localization for double Fourier series, 580

Bragg-Williams approximation Interacting enzyme systems at steady state: Further Monte Carlo

calculations on two-state molecules, 5260 Brain

see also Caudate nucleus; Cerebellum; Cerebrum; Hippocampus; Nervous system, central

Benzodiazepine binding: Competitive inhibition by fractions from porcine brain, 6319

Biological activity of brain gastrin-like peptidic material in humans: Its relationship with COOH-terminal octapeptide of cholecystokinin, 524

Bombesin: Specific binding to rat brain membranes, 5372 Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected

brain preparations, 2969 Central noradrenergic neurons visualized in thick sections by unlabeled

antibody method: Transmitter-specific Golgi image, 2502 "Dark-active" rat transformed into "light-active" rat by destruction of

24-hr clock: Function of 24-hr clock and synchronizers, 6276 Depolarizing agents and cyclic nucleotides regulate phosphorylation of

specific neuronal proteins in rat cerebral cortex slices, 5195 Direct phosphorylation of brain tyrosine hydroxylase by cyclic

AMP-dependent protein kinase: Mechanism of' enzyme activation, 4744

Endogenous protein inhibitor of high affinity binding of --aminobutyric acid to synaptic membranes of rat brain: Purification, 4024

Extrahypophysial distribution of corticotropin as function of brain size, 994

[l8F]Fluoro-dopa, an analogue of dopa, and its use in direct external measurements of storage, degradation, and turnover of intracerebral dopamine, 464

Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine, 6290

Histochemically distinct compartments in striatum of human, monkey, and cat demonstrated by acetylthiocholinesterase staining, 5723

Insulin identified in rat brain, 5737 Interaction of ligands with opiate receptors of'brain membranes:

Regulation by ions and nucleotides, 1713 Ionic factors in release of 45Ca2+ from chicken cerebral tissue by

electromagnetic fields, 6314 a-Melanocyte stimulating hormone: Immunohistochemical identification

and mapping in neurons of rat brain, 6300 Membrane-bound neuraminidase from calf brain: Regulation of

oligosialoganglioside degradation by membrane fluidity and membrane components, 122


[Met5]Enkephalin content in brain regions of rats treated with lithium, 2991

[5-Methionine]enkephalin and [5-leucine]enkephalin released in vitro from rat globus pallidus, 3503

Multiple receptors for brain dopamine, 1153 Nerve growth factor increases activity of ornithine decarboxylase in rat

brain, 1021 Neurons containing /-endorphin in rat brain exist separately from those

containing enkephalin: Immunocytochemical studies, 1591 Nontrypsin cholecystokinin converting enzyme in mammalian brain,

5711 Olfactory axons and synapse formation regenerated in forebrain after

bulbectomy in neonatal mice, 5230 Ontogeny of synaptic phosphoproteins in brain, 4037 31P nuclear mangetic resonance signals in brain detected by in vivo and

freeze-trapped assays, 4925 Regional dissociation of O-endorphin and enkephalin contents in rat

brain and pituitary (correction), 1608 Release of neurotransmitters and depletion of synaptic vesicles in

cerebral cortex slices by a-latrotoxin from black widow spider venom, 4016

Species-dependent immunological differences between vertebrate brain tubulins, 1414

Species specificity of cholecystokinin in gut and brain of several mammalian species, 486

Thy-I differentiation alloantigen associated with synaptic complexes isolated from mouse brain, 3283

Branched chain a-keto acid dehydrogenase complex Branched chain a-keto acid dehydrogenase complex of bovine kidney:

Purification and characterization, 4881 Brillouin light scattering

Brillouin light scattering measurement of elastic properties of aligned multilamella lipid samples, 1792

Bryamycin see Thiostrepton

Bufadienolide Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905 a-Bungarotoxin

Acetylcholine receptor levels regulated by a cholinergic agonist in mouse muscle cell cultures, 3488

o-Bungarotoxin blocks nicotinic transmission in avian ciliary ganglion, 2999


Nerve extract induces increase and redistribution of acetylcholine receptors on cloned muscle cells, 2035

Nonequivalence of a-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons, 1016

Snake venoms: Search for relationships among hemolytic, phospholipolytic, and neurotoxic activities, 600

,B-Bungarotoxin Neuromuscular transmission blocked by enzymatically active and

inactive /-bungarotoxin, 1029 Bursa

Small circular DNAs: Change in quantity and size distribution during development of chicken bursa, 5855

Butyrate Butyrate suppression of histone deacetylation leads to accumulation of

multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of associated DNA sequences, 2239

Caenorhabditis elegans Cell lineages of embryo of the nematode Caenorhabditis elegans, 376

Calcitonin Calcitonin and calcium ionophores: Cyclic AMP responses in cells of a

human lymphoid line, 3984 Parathyroid hormone- and calcitonin-activated adeinylate cyclases:

Development in embryonic chicken limb and in cultured cells from embryonic chicken limb, 3871

Calcium ATP-dependent Ca2+ uptake into plant membrane vesicles, 1232 Bombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139 Ca2+-dependent protein phosphorylation system in membranes from

various tissues, and its activation by "calcium-dependent regulator", 5432


Calcium affects structure and function of hyaluronic acid matrix: Carbon-13 nuclear magnetic resonance analysis and diffusional behavior of small solutes, 2261

Calcium-dependent regulator protein: Localization in mitotic apparatus of eukaryotic cells, 1867

Calcium leakage as cause of high resting tension in vascular smooth muscle from spontaneously hypertensive rat, 1605

Ca2+-related regulatory function of fibrinogen, 4234 Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329 Coupling of lac mRNA transcription to translation in Escherichia coli

cell extracts, 158 Electrotonic synapses uncoupled by calcium, 4577 Ionic factors in release of 45Ca2+ from chicken cerebral tissue by

electromagnetic fields, 6314 Loss of proliferative calcium dependence: Simple in vitro indicator of

tumorigenicity, 6069 Low molecular weight Ca2+ carrier isolated from calf heart inner

mitochondrial membrane, 2125 Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379 Microtubule assembly-disassembly controlled by calcium-dependent

regulator protein, 3771 Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of

calcium from exchangeable pool in isolated rat hepatocytes, 2234 Opposing effects of calcium and barium in vertebrate rod

photoreceptors, 1587 Parathyroid hormone- and calcitonin-activated adenylate cyclases:



Phosphatidylserine: Interaction with mast cells, 4997 Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512 Regulation of Ca2+ release from mitochondria by oxidation-reduction

state of pyridine nucleotides, 1690 Specific phosphorylation at serine-283 of oa tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588 Temperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325 Transmitter release: Changes induced by ion-containing liposomes, 5214 Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic

monophosphate levels in neuroblastoma cells, 6295 Calorimetry

Anesthetics and pressure: Effect on thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes, 4906

Gel to liquid crystal transition of synthetic phosphatidylcholines, 2258 Interaction of methotrexate, folates, and pyridine nucleotides with

dihydrofolate reductase: Calorimetric and spectroscopic binding studies, 3201

Proposed temperature-dependent conformational transition in D-amino acid oxidase: Differential scanning microcalorimetric study, 2584

Cancer see also Carcinogen, chemical; Carcinogenesis; Tumor; specific cancers;

specific cells Actinomycin D-deoxynucleotide interactions: Binding isotherms at

benzenoid and quinoid portions of the drug, 4729 Binding and internalization of epidermal growth factor in human

carcinoma cells A-431: Visualization by fluorescence, 3317 Cell surface antigens of malignant human brain tumors: Serological

analysis, 5122 Corticotropin, lipotropin, and k-endorphin production by a human

nonpituitary tumor in culture: Evidence for common precursor, 5160





Experimental studies designed to evaluate management of patients with incurable cancer, 4543

Experimental studies designed to evaluate management of patients with incurable cancer, 6252

Host-range variants of mouse mammary tumor viruses isolated that efficiently infect cells in vitro, 5718

Human tumors and human malignant cell lines analyzed for BK virus-specific DNA sequences, 454

Model for incidence of embryonal cancers: Application to retinoblastoma, 2453

Nucleosome rearrangement in human chromatin during UV-induced DNA repair synthesis, 4238

Photodestruction of pheomelanin: Role of oxygen, 5395 Self-nonself concept for cancer and diseases previously known as

"autoimmune" diseases, 5697 Somatic mutation and neoplastic transformation, 3297 Supplemental ascorbate in supportive treatment of cancer: Reevaluation

of prolongation of survival times in terminal human cancer, 4538 Unique tRNA species detected in tumor tissues by Escherichia coli

guanine insertion enzyme, 4247 Vasoactive intestinal peptide: Potent stimulator of adenosine 3':5'-cyclic

monophosphate accumulation in gut carcinoma cell lines in culture, 2772

Capacitation Stimulation of in vitro activation and the acrosome reaction of hamster

spermatozoa by catecholamines, 4954 Capping

H-2.28, an alloantigenic marker allelic to H-2.1, is expressed on all three known types of H-2 molecules, 4441

Histocompatibility antigens participate in capping of molecularly independent cell surface components by their specific antibodies, 2406

Model for capping of membrane receptors based on boundary surface effects, 1357

Capsid Determination of capsid size by satellite bacteriophage P4, 400

Carbachol Adenylate cyclase activity: Regulation mediated by muscarinic

acetylcholine receptors, 1788 Carbamoyl-phosphate synthase (ammonia) (EC 2.7.2.5)


Carbamylcholine Acetylcholine receptor levels regulated by a cholinergic agonist in mouse

muscle cell cultures, 3488 Carbamyl phosphate synthetase I

see Carbamoyl-phosphate synthase (ammonia) Carbohydrate

Carbohydrate structure and cell differentiation: Fucosyl-glycopeptides isolated from embryonal carcinoma cells, 2315

Carbon tetrachloride Lysyl oxidase: Biochemical and immunochemical study in experimental

hepatic fibrosis in rat, 2945 y-Carboxyglutamic acid

Vitamin K-dependent carboxylase: A hydroperoxide intermediate in the reaction, 5413

Carboxylase Vitamin K-dependent carboxylase: A hydroperoxide intermediate in the

reaction, 5413 Carcinogen, chemical

see also specific chemicals Azo dyes prevent hydrocarbon-induced leukemia in rat, 4524 Carcinogens enhance survival of UV-irradiated simian virus 40 in treated

monkey kidney cells: Induction of a recovery pathway? 346 Cell-free assay measuring repair DNA synthesis in human fibroblasts,

1887 Comutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928 Cyclopenta[c,d]pyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667 Endogenous RNA tumor viruses are activated during chemical induction

of murine plasmacytomas, 4549 Epoxide hydrase is the preneoplastic antigen in rat liver hyperplastic

nodules, 3240 Four trans-3,4-dihydrodiol metabolites of

7,12-dimethylbenz[alanthracene and their in vitro DNA-binding activities upon further metabolism, 5466

Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbonss, 2003

Isolation of stable rat sarcoma viruses in uitro, 2972 Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens,

2864 Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA

at positions of guanine and adenine, 4120 Modification of DNA by the benz[a]pyrene metabolite diol-epoxide

r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 415 Neoplastic transformation in vitro: Progressive nature, 3761 Neoplastic transformation of human diploid fibroblast cells by chemical

carcinogens, 1334 Neoplastic transformation of rat mammary cells exposed to

7,12-dimethylbenz[a]anthracene or N-nitrosomethylurea in cell culture, 3836

Polynucleotides containing 02- and 04-alkyluridine: Preparation and template activities, 1722

Principal aflatoxin B1-DI)NA adduct formed in vivo in rat liver: Identification, 1745

Subject Index 6351

Regio- and stereoselectivity of various forms of purified cytochrome P-450 in metabolism in benzo[a]pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydroxybenzo[a]pyrene as shown by product formation and binding to DNA, 3123

Somatic mutation and neoplastic transformation, 3297 Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647 Transformation of rat embryo cell cultures: Interactions between

adenovirus, a tumor promoter, and chemical carcinogens, 2311 Tumorigenicity of optical enantiomers of the diastereomeric

benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptional activity of (+)-7/,8o-dihydroxy-9ac, 10a-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene, 5358

Carcinogenesis Polycyclic aromatic hydrocarbons: Dose-dependent preferential binding

to reiterated DNA of murine skin cells in culture, 5841 Tumor promoter induces sister chromatid exchanges: Relevance to

mechanisms of carcinogenesis, 6149 Cardiac

see also Cell, heart; Heart Cardiac reaction

Differential sympathetic discharges in chemoreceptor reflexes, 5239 Cardiolipin

Cardiolipin: Stereospecifically spin-labeled analogue and its specific enzymic hydrolysis, 1227

Cardiotonic Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905 Cardiotoxicity

Rescue by coenzyme Qlo from electrocardiographic abnormalities caused by toxicity of adriamycin in rat, 5178

Carotenoid Photosynthetic unit size, carotenoids, and chlorophyll-protein

composition of Prochloron sp., a prokaryotic green alga, 2301 Carotid body

Carotid body chemoreceptor function: Hypothesis based on a new circuit model, 2507

Carpal tunnel syndrome Deficiency of vitamin B6 in carpal tunnel syndrome: Biochemical

evidence based on a crossover clinical study, 3410 Cartilage


DNA sequences amplified during chicken cartilage and neural retina differentiation, 4451

Mammalian lectin-like substance: Isolation, preliminary characterization, and interferon antagonistic effect, 2333

Casein Human T cell subsets: Heterogeneity of locomotion, 2392

Castration Specific regulation by steroid hormones of amount of type I cyclic

AMP-dependent protein kinase holoenzyme, 223 Catalase

Fluorescent light-induced chromosome damage and its prevention in mouse cells in culture, 1830

Catalase (EC 1.11.1.6) Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and

uricase, 5066 Catalase: Synthesis in two cell-free protein-synthesizing systems and in

rat liver, 4344 Cataract


Diabetic cataract formation: Potential role of glycosylation of lens crystallins, 2918

Disulfide-linked high molecular weight protein associated with human cataract, 3244


Catecholamine see also Transport, catecholamine Adenylate cyclase activation through the /-adrenergic receptor:

Catecholamine-induced displacement of bound GDP by GTP, 4155 Differential desensitization of functional adrenergic receptors irn normal

and malignant myeloid cells: Relationship to receptor-mediated hormone cytotoxicity, 1805

Interneuron involved in generation of slow inhibitory postsynaptic potential in mammalian sympathetic ganglia, 4029



Transmembrane pH gradient: Role in epinephrine transport by chromaffin granule membrane vesicles, 3713

Tyrosine hydroxylase and catecholamines: Ontogenetic appearance and disappearance in rat embryo, 2986


Cauchy problem Yang-Mills equations in physical space: General properties, 4638

Cauchy-Riemann manifold Local analytic hypoellipticity for ?b on nondegenerate

Cauchy-Riemann manifolds, 3027 Caudate

Serotonin receptors selectively labeled by d-[3H]lysergic acid diethylamide in calf caudate, 5783



6352 Subject Index

Caudate nucleus os-Adrenergic receptors in caudate nucleus selectively labeled by

[3H]dihydroergocryptine in presence of spiperone-blocked dopamine receptors, 2249

Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei, 1546

Cebus albifrons Protein deficiency and energy restriction in young cebus monkeys, 1600

Cell see also Differentiation, cell; Hybrid cell; specific cells

Cell adhesion Cell adhesion to substrates containing adsorbed or attached IgG, 1366 Codistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944 Fibronectin: Identification, localization, and role in cultured bovine

endothelial cells, 3273 Proteases induce secretion of collagenase and plasminogen activator by

fibroblasts, 1839 Cell, adrenal

Gonadal luteinizing hormone receptors and adenylate cyclase: Transfer of functional ovarian luteinizing hormone receptors to adrenal fasciculata cells, 4769

Cell, adrenal chromaffin Nerve growth factor-induced fiber outgrowth from isolated rat adrenal

chromaffin cells: Impairment by glucocorticoids, 3498 Cell aggregation

Induced cell aggregation and mating in Streptococcus faecalis: Evidence for bacterial sex pheromone, 3479

Cell, AKR Physical, morphological, and biochemical alterations in membrane of

AKR mouse cells after interferon treatment, 1859 Cell, ascites tumor

mRNA-dependent synthesis of a glycosylated subunit of human chorionic gonadotropin in cell-free extracts derived from ascites tumor cells, 1768

Cell, atypical mast Immunofluorescent localization of a serine protease in rat small

intestine, 2785 Cell, B

Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD, 432

Clonal dominance: Loss and restoration in adoptive transfer, 1967 Control of proliferation and differentiation in B lymphocytes by anti-Ig

antibodies and a serum-derived cofactor, 2401 Ia-like antigens: Expression on cultured human malignant melanoma cell

lines, 6235 Immunoglobulin secretion from human neoplastic lymphoid cells rescued

by somatic cell hybridization, 2411 Lymphoblastoid cell lines from patients with chronic lymphocytic

leukemia: Identification of tumor origin by idiotypic analysis, 5706 Restricted classes of immunoglobulin produced by lymphoid cell line

from patient with agammaglobulinemia, 2421 Small circular DNAs: Change in quantity and size distribution during

development of chicken bursa, 5855 Cell, bag

Neuronal interaction mediated by behaviorally active peptide, 5732 Neurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200 Cell, blood

Normal blood cells of anemic genotype in teratocarcinoma-derived mosaic mice, 6247

Cell, bone marrow Hemopoietic stem cell transplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933 Cell, BSC-1

Density-dependent regulation of growth of BSC-1 cells in cell culture: Control of growth by low molecular weight nutrients, 339


Cell, chemoreceptor Carotid body chemoreceptor function: Hypothesis based on a new circuit

model, 2507 Cell, chick embryo

Oligonucleotide inhibitor of protein synthesis made in extracts of interferon-treated chick embryo cells: Comparison with mouse low molecular weight inhibitor, 1167

Cell, chicken Sites of integration of reticuloendotheliosis virus DNA in chicken DNA,

3372 Cell, Chinese hamster

Cytoplasmic transfer of resistance to antimycin A in Chinese hamster cells, 5604

Genetic analysis of Gl period: Isolation of mutants (or variants) with a G1 period from Chinese hamster cell line lacking G1, 2873

Ornithine decarboxylase activity: Induction in a temperature-sensitive cell cycle mutant of Chinese hamster cells, 5001

Simian virus 40 A gene function: DNA content analysis of Chinese hamster cells transformed by early temperature-sensitive virus mutant, 4389

Cell, Chinese hamster ovary Actinomycin D inhibits initiation of DNA replication in mammalian

cells, 6088 Amplified dihydrofolate reductase genes are localized to a

homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line, 5553

Defective regulation of cholesterol biosynthesis and plasma membrane fluidity in Chinese hamster ovary cell mutant, 1247


Electrophoretic shift mutants in Chinese hamster ovary cells: Evidence for genetic diploidy, 1919

Inverted repeated DNA from Chinese hamster ovary cells studied with cloned DNA fragments, 2679

Late S phase cells (Chinese hamster ovary) induce early S phase DNA labeling patterns in G1 phase nuclei, 3307

Mammalian cell mutant requiring cholesterol and unsaturated fatty acid for growth, 5452

Replica plating and in situ enzymatic assay of animal cell colonies established on filter paper, 1190


Cell culture Erythroid colony formation from human fetal liver, 984

Cell culture, synchronized Kinetics of desynchronization and distribution of generation times in

synchronized cell populations, 4404 Cell cycle

Cell lineages of embryo of the nematode Caenorhabditis elegans, 376 Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810 Diadenosine 5',5"'-P1,P4-tetraphosphate triggers initiation of in vitro

DNA replication in baby hamster kidney cells, 371 Genetic analysis of GI period: Isolation of mutants (or variants) with a

G1l period from Chinese hamster cell line lacking G1, 2873 Globin mRNA: Synthesis in relation to cell cycle during induced murine

erythroleukemia differentiation, 3801 G2 phase-specific proteins of HeLa cells, 6064 Inducers of DNA synthesis present during mitosis of mammalian cells

lacking Gl and G2 phases, 5043 Inhibition of growth and guanylate cyclase activity of undifferentiated

prostate adenocarcinoma by extract of balsam pear (Momordica charantia abbreuiata), 989

Kinetics of desynchronization and distribution of generation times in synchronized cell populations, 4404


Lengthening of G1 phase is not strictly correlated with differentiation in Friend erythroleukemia cells, 3813

Methionine analogs and cell division regulation in Saccharomyces cerevisiae, 6083

Mid-Gi marker protein(s) in 3T3 mouse fibroblast cells, 4959 Ornithine decarboxylase activity: Induction in a temperature-sensitive

cell cycle mutant of Chinese hamster cells, 5001 Rate of macromolecular synthesis through cell cycle of Saccharomyces

cerevisiae, 4384 Simian virus 40 A gene function: DNA content analysis of Chinese

hamster cells transformed by early temperature-sensitive virus mutant, 4389


Cell division Cell lineages of embryo of the nematode Caenorhabditis elegans, 376 Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057 Methionine analogs and cell division regulation in Saccharomyces

cerevisiae, 6083 Cell, embryonal carcinoma


Embryonal carcinoma cells: Growth in serum-free medium, 1844 High molecular weight cell surface glycoprotein (LETS protein)

expressed by preimplantation mouse embryos and teratocarcinoma stem cells, 2324

Metabolic cooperation between mouse embryonal carcinoma cells and their differentiated derivatives, 3292

Cell, endothelial Role of contact inhibition in regulation of receptor-mediated uptake of

low density lipoprotein in cultured vascular endothelial cells, 356 Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621 Fibronectin: Identification, localization, and role in cultured bovine

endothelial cells, 3273 Cell, epidermal

Polycyclic aromatic hydrocarbons: Dose-dependent preferential binding to reiterated DNA of murine skin cells in culture, 5841

Cell, epithelial Anti-epidermal-cell-surface pemphigus antibody detaches viable

epidermal cells from culture plates by activation of proteinase, 459 Asymmetric budding of viruses in epithelial monolayers: Model system

for study of epithelial polarity, 5071 Density-dependent regulation of growth of BSC-1 cells in cell culture:

Growth inhibitors formed by the cells, 1864 Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548 Regulation of corneal collagenase production: Epithelial-stromal cell

interactions, 4417 Cell, epithelioid

Loss of proliferative calcium dependence: Simple in vitro indicator of tumorigenicity, 6069

Cell, erythroleukemia Altered nucleosome spacing in newly replicated chromatin from Friend

leukemia cells, 5903 Changes in genome composition of Friend virus complex in

erythroleukemia cells during differentiation induced by dimethyl sulfoxide, 3278

Dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation inhibited by hydrocortisone and other steroids, 3851

Globin mRNA: Synthesis in relation to cell cycle during induced murine erythroleukemia differentiation, 3801

Growth hormone modulation of murine erythroleukemia cell growth in vitro, 3437




Induction of murine erythroleukemia differentiation by actinomycin D, 2795

Lengthening of Gl phase is not strictly correlated with differentiation in Friend erythroleukemia cells, 3813

Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa cells observed by high-resolution 31p nuclear magnetic resonance, 891

Cell, fat see also Adipocyte; Cell, preadipocyte Epinephrine-induced elevation of guanosine 3':5'-cyclic monophosphate

in isolated fat cells of rat, 2684 Cell, Friend

see Cell, erythroleukemia Cell fusion

Antibodies against human melanonma produced by somatic cell hybrids, 3405

Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected brain preparations, 2969


G2 phase-specific proteins of HeLa cells, 6064 Spectrin participates in Sendai virus-induced fusion of human

erythrocyte ghosts, 1740 Cell, GH1

Thyroid and glucocorticoid hormones synergistically control growth hormone mRNA in cultured GH1 cells, 45

Cell, glial Nerve growth factor increases activity of ormnithine decarboxylase in rat

brain, 1021 Cell, glomus

Carotid body chemoreceptor function: Hypothesis based on a new circuit model, 2507

Cell growth Density-dependent regulation of growth of BSC-1 cells in cell culture:

Control of growth by low molecular weight nutrients, 339 Density-dependent regulation of growth of BSC-l cells in cell culture:

Growth inhibitors formed by the cells, 1864 Growth of 3T3 cells inhibited by extract of surface membranes, 5457 Growth of transformed cells and tumors inhibited by endogenous

acceptor of galactosyltransferase, 4426 Growth state-dependent phenotypes of adult hepatocytes in primary

monolayer culture, 1834 HeLa cells: Growth and maintenance in serum-free medium

supplemented with hormones, 901 Ordered sequence of events is required before BALB/c-3T3 cells become

committed to DNA synthesis, 2839 Receptor-mediated uptake of low density lipoprotein reconsitituted with

25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts, 5052

Cell, heart see also Cardiac; Heart In vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776 Muscarinic acetylcholine receptors in heart cell cultures, 5831

Cell, HeLa Cholesterol biosynthesis in HeLa S3G cells regulated by serum

lipoproteins: Dexamethasone-mediated interference with suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, 2103

Evidence from UV transcription mapping in HeLa cells that heterogeneous nuclear RNA is the messenger RNA precursor (correction), 1043

G2 phase-specific proteins of HeLa cells, 6064 HeLa cell DNA synthesis: Initiation in a subnuclear system, 5931 HeLa cells: Growth and maintenance in serum-free medium

supplemented with hormones, 901 Malignancy in human cells: Malignant and transformed phenotypes are

under separate genetic control, 1466 Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa

cells observed by high-resolution 31P nuclear magnetic resonance, 891 Cell, hematopoietic stem

Proliferative capacity of murine hematopoietic stem cells, 490 Cell, human diploid

Colony size distributions as measure of in vivo and in vitro aging, 1353 Cell, hybrid

see Hybrid cell Cell, Hydra stem

Regulation of self-renewal probability in Hydra stem cell clones, 886 Cell, kidney

Animal cells reversibly permeable to small molecules, 351 Attachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408 Carcinogens enhance survival of UV-irradiated simian virus 40 in treated

monkey kidney cells: Induction of a recovery pathway? 346 Diadenosine 5',5"'-P1,P4-tetraphosphate triggers initiation of in vitro

DNA replication in baby hamster kidney cells, 371 Endogenous New World primate type C viruses isolated from owl

monkey (Aotus trivirgatus) kidney cell line, 1004 Reversion of transformed glycolysis to normal by inhibition of protein

synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus, 5015

Ten-nanometer filaments of hamster BHK-21 cells and epidermal keratin filaments have similar structures, 6098

Cell, L Isolation of two interferon-induced translational inhibitors: A protein

kinase and an oligo-isoadenylate synthetase, 4734 Potassium transport in L cells: Genetic alterations, 5589

Subject Index 6353

Cell, leukemia Cytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folate

cofactors and antagonism by methotrexate, 980 Cell, leukemic

Decreased microviscosity of membrane lipids in leukemic cells: Two possible mechanisms, 2306

Cell, Leydig tumor Gonadotropin binding and stimulation of steroidogenesis in Leydig

tumor cells, 99 Cell, lung

see also Lung Fluorescent light-induced chromosome damage and its prevention in

mouse cells in culture, 1830 Cell, luteal

Mechanism of rapid antigonadotropic action of prostaglandins in cultured luteal cells, 1344

Cell, lymphoblastoid Lymphoblastoid cell lines from patients with chronic lymphocytic

leukemia: Identification of tumor origin by idiotypic analysis, 5706 Cell, lymphocytic

see also Lymphocyte Collagen biosynthetic activities expressed in lymphocytic cells, 1379

Cell, lymphoid /2-Microglobulin aind HLA antigens: Enhanced expression on human

lymphoid cells by interferon, 6215 Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa

cells observed by high-resolution 31P nuclear magnetic resonance, 891 Translocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076 Cell, lymphoid dendritic

Lymphoid dendritic cells are potent stimulators of primary mixed leukocyte reaction in mice, 5132

Cell, lymphoma see also Lymphoma Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated


Differences in behavior and prognosis between leukemic and lymphomatous forms of a transplantable hamster lymphocytic neoplasm induced by simian virus 40, 2011

Differences in behavior and prognosis between leukemic and lymphomatous forms of a transplantable hamster lymphocytic neoplasm induced by simian virus 40 (correction), 3535

Production of autoinhibitory factors by mouse lymphoma cells in vitro and its relationship to thiol dependence, 1849

Cell, mammalian Increased incorporation of adenosine into adenine nucleotide pools in

serum-deprived mammalian cells, 1145 Cell, mammary

Neoplastic transformation of rat mammary cells exposed to * 7,12-dimethylbenz[a]anthracene or N-nitrosomethylurea in cell culture, 3836

Cell, mast Major serine protease in rat skeletal muscle: Its mast cell origin, 5311 Phosphatidylserine: Interaction with mast cells, 4997

Cell morphology Specificity of effects of cytochalasin B on transport and motile processes,

329 Cell motility

Biochemistry of actomyosin-dependent cell motility (Review), 588 Human T cell subsets: Heterogeneity of locomotion, 2392 Molecular cytochemistry: Incorporation of fluorescetntly labeled actin

into living cells, 857 Potent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220 Specificity of effects of cytochalasin B on transport and motile processes,

329 Cell, Muller

Generation of b-wave currents in skate retina, 5727 Cell, muscle

Acetylcholine receptor levels regulated by a cholinergic agonist in mouse muscle cell cultures, 3488

Factor from neurons increases the number of acetylcholine receptor aggregates on cultured muscle cells, 4011

Membrane particle aggregates in innervated and noninnervated cultures of Xenopus embryonic muscle cells, 500

Nerve extract induces increase and redistribution of acetylcholine receptors on cloned muscle cells, 2035

Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells, 319

Synapse turnover: Mechanism for acquiring synaptic specificity, 2281 Cell, myeloid leukemic

Differential desensitization of functional adrenergic receptors in normal and malignant myeloid cells: Relationship to receptor-mediated hormone cytotoxicity, 1805

Indirect induction of differentiation in myeloid leukemic cells by lipid A, 1374

Induction of normal differentiation in myeloid leukemia cells in vivo, 3781

Cell, myoepithelial THY-I: Differentiation marker of potential mammary myoepithelial cells

in vitro, 6093 Cell, neural retina

Embryonic neural retina collagen: In vitro synthesis of high molecular weight forms of type II plus a new genetic type, 3235

Cell, neuroblastoma Biosynthesis in vitro of fucose-containing glycosphingolipids in human

neuroblastoma IMR-32 cells, 289



6354 Subject Index

DNA polymerase activities in differentiating mnouse neuroblastoma N-18 cells, 1289

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218 Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic

monophosphate levels in neuroblastoma cells, 6295 Cellobioside

Rhynchosporoside, a host-selective toxin produced by Rhynchosporium secalis, the causal agent of scald disease of barley, 4339

Cell, pancreatic acinar Bombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139 Cell, parathyroid

Role of anions in parathyroid hormone release from dispersed bovine parathyroid cells, 876

Cell permeability Animal cells reversibly permeable to small molecules, 351

Cell, pheochromocytoma Nerve growth factor-mediated induction of tyrosine hydroxylase in

clonal pheochromocytoma cell line, 4587 RNA synthesis-dependent and -independent pathways in stimulation of

neurite outgrowth by nerve growth factor, 6059 Cell, pituitary tumor

Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294 Cell, placental

see also Placenta Clonal human placental cells established synthesizing human

choriogonadotropin, 1854 Human placental cells transformed by tsA mutants of simian virus 40:

Model system for study of placental functions, 1409 Cell, preadipocyte

Preadipocyte clonal line established froom epididymal fat pad of ob/ob mouse that responds to insulin and to lipolytic hormones, 6054

Cell proliferation Dexamethasone modulates binding and action of epidermal growth

factor in serum-free cell culture, 1882 Growth state-dependent phenotypes of adult hepatocytes in primary

monolayer culture, 1834 Cell, promyelocytic leukemia

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds, 2458

Cell, pyramidal Pyramidal cells identified as critical elements in hippocampal neuronal

plasticity during learning, 1572 Cell, Raji

Transforming activity of Epstein-Barr virus obtained by superinfection of Raji cells, 2008

Cell, rat embryo Transformation of rat embryo cell cultures: Interactions between

adenovirus, a tumor promoter, and chemical carcinogens, 2311 Cell recognition

Egg surface glycoprotein receptor for sea urchin sperm bindin, 881 Cell separation

"Panning" for lymphocytes: Method for cell selection, 2844 Cell, small intensely fluorescent

Interneuron involved in generation of slow inhibitory postsynaptic potential in mammalian sympathetic ganglia, 4029

Cell sorting Myeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901 Cell, spleen

Hemopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins, 2933

Thymic hormone-like restoration by human prealbumin of azathioprine sensitivity of spleen cells from thymectomized mice, 823

Trypanosome-mediated suppression of humoral immunity in mice: Mechanisms, 3923

Cell, stem Hemopoietic stem cell transplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933 Segregation of different cell lines in vitro with neuronal and glial

properties from stem cell line of rat neurotumor RT4, 6305 Teratocarcinomas: Somatic cell origin, 2834 THY-i: Differentiation marker of potential mammary myoepithelial cells

in vitro, 6093 Cell, stromal

Regulation of corneal collagenase pro(luction: Epithelial-stromal cell interactions, 4417

Cell, suppressor Leukemia in AKR mice: Defined suppressor cell population expressing

membrane-associated DNA, 6211 Loss of human supressor cells during active autoimmune disease, 5150 Regulation of antibody heterogeneity by suppressor T cells: Diminishing


Suppressor cell activity altered in chronic active hepatitis, 1549 Systemic bacillus Calmette-Guerin (BCG) activates natural suppressor

cells, 5142 Trypanosome-mediated suppression of humoral immunity in mice:

Mechanisms, 3923 Cell surface

see also Antigen, cell surface; Receptor, cell-surface Actin may be present on lymphocyte surface, 4484 Cell surface of Micrococcus radiodurans: Topographic study, 5525 Genetic analysis of human cell surface: Antigenic marker for human X

chromosome in human-mouse hybrids, 2363 Histocompatibility antigens participate in capping of molecularly

independent cell surface components by their specific antibodies, 2406



Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrients by quiescent BALB/C3T3 cells, 3859

Cell, T Activated human T lymphocytes display new surface glycoproteins, 3455 Adult murine T cells activated in vitro by a-fetoprotein and naturally

occurring T cells in newborn mice: Identity in function and cell surface differentiation antigens, 2897

Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells, 5145

Cholesterol is a critical cellular component for T-lymphocyte cytotoxicity, 5683

Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus, 3464

H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur in chimeric mice, 6207

Human T cell subsets: Heterogeneity of locomotion, 2392 Immunoglobulin K chain RNA in thymus T cells: Direct demonstration

by in situ hybridization, 2905 Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response


Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice, 2439

Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line, 5674

Natural species-restricted attachment of human and murine T lymphocytes to various cells, 2396

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes, 441


Regulation of antibody heterogeneity by suppressor T cells: Diminishing suppressor T cell activity increases number of dinitrophenyl clones in mice immunized with dinitrophenyl-poly(Glu,Lys,Phe) or dinitrophenyl-poly(Glu,Lys,Ala), 2914

RNA content in human lymphocyte subpopulations, 1938 Secondary cytotoxic T lymphocytes induced by purified HLA-A and

HLA-B antigens reconstituted into phospholipid vesicles, 5688 Selective association of murine T lymphoblastoid cell surface

alloantigens with Mycoplasma hyorhinis, 4479 Spontaneous and antibody-dependent cell-mediated cytotoxicity by

human T cell subpopulations, 5137 T-cell helper function: Regeneration in zinc-deficient adult mice, 5660 T lymphocytes: Role in cellular immune responses during herpes simplex

virus infection in humans, 3957 Tuftsin (an Ig-associated tetrapeptide) triggers immunogenic function of

macrophages: Implications for activation of programmed cells, 3400 Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted

lysis of infected cells by cytotoxic T lymphocytes, 970 Cell, 3T3

Adipose conversion of 3T3 cells depends on a serum factor, 6107 Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810 DNA synthesis in growing BALB/c 3T3 mouse cells controlled by a

fibroblast growth regulatory factor, 6115 Growth of 3T3 cells inhibited by extract of surface membranes, 5457 Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379 Ordered sequence of events is required before BALB/c-3T3 cells become

committed to DNA synthesis, 2839 Transfer of duck cell DNA sequences to nucleus of 3T3 cells by Rous

sarcoma virus, 4252 Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrients

by quiescent BALB/C3T3 cells, 3859 Cell, target

Natural species-restricted attachment of human and murine T lymphocytes to various cells, 2396

Cell, thymus Proliferative response to alloantigen amplified by factor present in

extract of syngeneic thymic lymphoid cells, 4474 Cell, vascular endothelial

Role of contact inhibition in regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells, 356

Cell wall Escherichia coli mutant isolated lacking penicillin-sensitive D-alanine

carboxypeptidase IA, 2631 Cephalosporins

Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by Cephalosporium acremonium CW-19 and its mutants, 6253

Cephalosporium acremonium Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by

Cephalosporium acremonium CW-19 and its mutants, 6253 Cerebellum

Y-Aminobutyric acid receptors: Ultrastructural localization in mammalian central nervous system by means of [3H]muscimol binding, 2977

Cerebral cortex Cholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324 Cerebrospinal fluid

/-Endorphin-like immunoreactivity appears in human ventricular cerebrospinal fluid upon analgesic electrical stimulation, 5170

Multiple sclerosis cerebrospinal fluid: Components detected by radioimmunoassay for myelin basic protein, 1976




Cerebrum --Aminobutyric acid transport modulated in nerve endings: Role of

extracellular y-aminobutyric acid and of cationic fluxes, 2981 Cerium

Crystal structures of (W"-cerium phases, 1066 Ceruloplasmin

see Ferroxidase Chaos carolinensis


Charge transfer Internal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548 Chemically induced dynamic nuclear polarization


Chemiluminescence see also Bioluminescence; Luminescence Hydrogen peroxide production, chemiluminescence, and respiratory

burst of fertilization: Interrelated events in early sea urchin development, 3183

Chemoreceptor reflex Differential sympathetic discharges in chemoreceptor reflexes, 5239

Chemotaxis S-Adenosyl-L-methionine-mediated methylation required for human

monocyte chemotaxis, 3928 Chemotactic attraction of human fibroblasts to type I, II, and III

collagens and collagen-derived peptides, 871 Human T cell subsets: Heterogeneity of locomotion, 2392 Inversion of a behavioral response in bacterial chemotaxis: Explanation

at molecular level, 4150 Potentiation, desensitization, and inversion of response in bacterial

sensing of chemical stimuli, 2820 Protein methylesterase involved in bacterial sensing, 3659 Specific C5a receptor demonstrated on intact human polymorphonuclear

leukocytes, 3943 Chemotherapeutic agent


Chipmunk Existence of a yearly clock in surgically and self-blinded chipmunks,

3517 Chlamydomonas reinhardtii

Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation and characterization, 3268

Post-translational transport into intact chloroplasts of precursor to small subunit of ribulose-l,5-bisphosphate carboxylase, 6110

Chloramphenicol Teratocarcinoma cells as vehicles for introducing specific mutant

mitochondrial genes into mice, 511.3 Chloroacetaldehyde

Exposure of DNA bases induced by interaction of DNA and calf thymus DNA helix-destabilizing protein, 4689

Chlorophyll see also Bacteriochlorophyll Coherent stimulated light emission (lasing) in covalently linked

chlorophyll dimers, 2076 Photoprocesses in covalently linked pyrochlorophyllide dimer: Triplet

state formation and opening and closing of hydroxylic linkages, 2563 Photosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801 Photosynthetic unit size, carotenoids, and chlorophyll-protein

composition of Prochloron sp., a prokaryotic green alga, 2301 Chloroplast

Post-translational traunsport into intact chloroplasts of precursor to small subunit of ribulose-l,5-bisphosphate carboxylase, 6110

Cholecystokinin Biological activity of brain gastrin-like peptidic material in humans: Its

relationship with COOH-terminal octapeptide of cholecystokinin, 524 Cholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324 Nontrypsin cholecystokinin converting enzyme in mammalian brain,

5711 Species specificity of cholecystokinin in gut and brain of several

mammalian species, 486 Cholecystokinin converting enzyme

Nontrypsin cholecystokinin converting enzyme in mammalian brain, 5711

Choleragen see Toxin, cholera

Cholestasis Lipoprotein-X: Secretion by perfused livers of rats with cholestasis, 3459

Cholesterol Brillouin light scattering measurement of elastic properties of aligned

multilamella lipid samples, 1792 Cholesterol biosynthesis in HeLa S3G cells regulated by serum


Cholesterol is a critical cellular component for T-lymphocyte cytotoxicity, 5683

Cholesterol monohydrate growth in model bile solutions, 6230 Defective regulation of cholesterol biosynthesis and plasma membrane

fluidity in Chinese hamster ovary cell mutant, 1247 3-Hydroxy-3-methylglutaryl coenzyme A reductase: Regulation of

enzymatic activity by phosphorylation and dephosphorylation, 3678 Mammalian cell mutant requiring cholesterol and unsaturated fatty acid

for growth, 5452

Subject Index 6355

Receptor-mediated uptake of low density lipoprotein reconsitituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts, 5052

Cholesterol acyltransferase (EC 2.3.1.26) Cholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877 Cholesterol, 25-hydroxy-


Cholesterol, 7-keto- Cholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877 Choline

Different time course of development for high-affinity choline uptake and choline acetyltransferase in chick retina, 2525

Choline acetyltransferase (EC 2.3.1.6) Different time course of development for high-affinity choline uptake

and choline acetyltransferase in chick retina, 2525 Cholinesterase (EC 3.1.1.8)

"Nonspecific" cholinesterase and acetylcholinesterase in rat tissues: Molecular forms, structural and catalytic properties, and significance of the two enzyme systems, 2588

Chondrogenesis Induction de novo of a gene product during heterologous

epithelial-mesenchymal interactions in vitro, 2790 Choriogonadotropin

Clonal human placental cells established synthesizing human choriogonadotropin, 1854

Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells, 99.

Human chorionic gonadotropin: Interaction with membrane components of rat testes, 764

Human placental cells transformed by tsA mutants of simian virus 40: Model system for study of placental functions, 1409


Choriomammotropin Mixed recombinants of human growth hormone and chorionic

somatomammotropin: Immunoreactivity and receptor binding, 5391 Noncovalent interaction of NH2-terminal fragment of human

somatotropin with COOH-terminal fragment of human choriomammotropin to generate growth-promoting activity, 1700

Chorion Silkmoth chorion proteins: Sequence analysis of products of a multigene

family, 390 Chorionic gonadotropin

see Choriogonadotropin Chorionic somatomammotropin

see Choriomammnotropin Chromaffin vesicle

Catecholamine transport into chromaffin vesicles is coupled to vesicle membrane potential, 5190


Chromatid Fluorescent light-induced DNA crosslinkage and chromatid breaks in

mouse cells in culture, 3809 Tumor promoter induces sister chromatid exchanges: Relevance to

mechanisms of carcinogenesis, 6149 Chromatin

Acetylated histone H4 is preferentially associated with template-active chromatin, 3574

Altered nucleosome spacing in newly replicated chromatin from Friend leukemia cells, 5903

Altered nucleosome structure containing DNA sequences complementary to 19S and 26S ribosomal RNA in Physarum polycephalum, 1116

Alternative structure for DNA: Implications, 4092 Assembly of new nucleosomal histones and new DNA into chromatin,

2130 Butyrate suppression of histone deacetylation leads to accumulation of


Chromatin structure in cellular slime mold Dictyostelium discoideum, 705

Chromatin subunit: Conformational changes, 660 Compact oligomers and nucleosome phasing, 3583 Correlation between phosphorylated HI histones and satellite DNAs in

Drosophila virilis, 866 DNA in chromatin: Possibility of nonkinked packing, 103 Gene adjacent to satellite DNA in Drosophila melanogaster, 5898 H-1 histone in rat liver nuclei: Displacement and aberrant mnethylation

in vitro after half-saturation of chromatin with polycations, 5773 Histone core complex: Characterization, 1680 Histone packing in nucleosome core particle of chromatin, 3649 How many base-pairs per turn does DNA have in solution and in

chromatin? Theoretical calculations, 640 In vitro transcription of heat-shock-specific RNA from chromatin of

Drosophila melanogaster cells, 759 Minichromosome from BK virus as template for transcription in vitro,

1126 Mononucleosome DNA conformation: Circular dichroism analysis, 4759 Nuclear antigens in Novikoff hepatoma: Purification, 1943 Nucleosome core particle of chromatin: Sequence of histone arrangement

along DNA, 4184 Nucleosome rearrangement in human chromatin during UV-induced

DNA repair synthesis, 4238



6356 Subject Index

Nucleosomes associated with newly replicated DNA have altered conformation, 2717

Origin of DNA replication in papovavirus chromatin is recognized by enmdogenous endonuclease, 5964

Protein factor that inhibits binding and promotes release of androgen-receptor complex from nuclear chromatin, 5969

Transcription patterns of amplified Dytiscus genes coding for ribosomal RNA after injection into Xenopus oocyte nuclei, 3791

Chromatography, affinity Affinity purification of cardiac adenylate cyclase: Dependence on prior

hydrophobic resolution, 59 Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with

fragment A from diphtheria toxin, 5319 Combined immunofluorescence and high-voltage electron microscopy of

cultured mammalian cells, using an antibody that binds to glutaraldehyde-treated tubulin, 334

Corticotropin, lipotropin, and /-endorphin production by a human nonpituitary tumor in culture: Evidence for common precursor, 5160

Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein, 2338

Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: Noinidentity of e antigen with immunoglobulins, 1952

Fibroinectin is the collagen receptor on platelet membranes, 5864 Fusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737 Glucose-6-phosphate dehydrogenase deficiency: Biochemical

mechanisms, 1979 Insulin and epidermal growth factor-urogastrone: Affinity crosslinking to

specific binding sites in rat liver membranes, 1675 Insulin receptor: Interaction with nonreceptor glycoprotein from liver

cell membranes, 3070 Isolation and characterization of normal crossreacting antigen: Homology



Nerve growth factor in mouse and rat serum: Correlation between bioassay and radioimmunoassay determinations, 4042


RNA metabolism, manganese, and RNA polymerases of zinc-sufficient and zinc-deficient Euglena gracilis, 4175

Specific binding of messenger RNA and methionyl-tRNAfMet by same initiation factor for eukaryotic protein synthesis, 209

Chromatography, column Two chromatographically separable forms of Escherichia coli elongation

factor Tu, 1140 Chromatography, covalent


Chromatography, deoxyribonucleic acid-cellulose Enrichment of special Novikoff hepatoma and regenerating liver mRNA

by hybridization to cDNA-cellulose, 1736 Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647 Chromatography, gas

Lipid A and endotoxin in serum determined by mass spectroscopy, 3993 Chromatography, ion-exchange

Molecular alteration in a Neurospora crassa morphological mutant and its phenocopy, 1461

Chromatography, liquid Absolute configuration of diastereomers of adenosine

5'-0-(1-thiotriphosphate): Consequences for stereochemistry of polymerization by DNA-dependent RNA polymerase from Escherichia coli, 4798

Four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism, 5466

Genes for human insulin: Chemical synthesis, 5765 Principal aflatoxin B1-DNA adduct formed in vivo in rat liver:

Identification, 1745 Pro-opiocortin, a precursor to opioid peptides and corticotropin, 669 Specificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone 1, 185 Chromatography, thin-layer

Polypeptide hormones: Chemical determination, 4115 Chromatography, two-dimensional


Polypeptide encoded by avian sarcoma virus src gene: Identification, 1567

Potato spindle tuber and citrus exocortis viroids undergo no major sequence changes during replication in two different hosts, 951

Chromium Bond angles in transition metal tetracarbonyl compounds: Test of theory

of hybrid bond orbitals, 569 Bond angles in transition-metal tricarbonyl compounds: Test of the

theory of hybrid bond orbitals, 12 Chromosome

Binding to chromosomes of herpes simplex-related antigens in biochemically transformed cells, 3288

Histone H1 and H2B production: Species-specific suppression in human-mouse hybrids, 5599

Inducers of DNA synthesis present during mitosis of mammalian cells lacking G1 and G2 phases, 5043


Tetrahymena macronuclear DNA: Viscoelastic studies, 5062 Thymidine kinase and galactokinase genes: Cotransfer by

chromosome-mediated gene transfer, 914 Chromosome, bacterial

Bacteriophage X carrying the Escherichia coli chromosomal region of replication origin, 5099

Chromosomal integration of phage X by a DNA insertion element, 1490 Uracil incorporation: Source of pulse-labeled DNA fragments in

replication of Escherichia coli chroomosome, 233 Chromosome, Chinese hamster

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line, 5553


Chromosome condensation Unique structures formed by pyrimidine-purine DNAs which may be

four-stranded, 1637 Chromosome, Drosophila


Sequence organization and transcription at two heat shock loci in Drosophila, 5613

Chromosome, human Altered pattern of replication of human chromosomes in a human

fibroblast-mouse cell hybrid, 1470 Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene to

pter --- q22 region of human chromosome 7 by bioautography, 6159 Banding patterns in human metaphase chromosomes enhanced by

energy transfer, 5650 Base ratio, DNA content, and quinacrine-brightness of human

chromosomes, 3382 Chromosomal assignment for a simian virus 40 integration site in human

cells, 4460 Chromosomal localization of human (3 globin gene on human

chromosome 11 in somatic cell hybrids, 1456 Epstein-Barr virus and human chromosomes: Close association of



Genes for human heavy chain immunoglobulin located to chromosome 6, 3367

Genetic analysis of human cell surface: Antigenic marker for human X chromosome in human-mouse hybrids, 2363

Genetics of large, external, transformation-sensitive (LETS) protein: Assignment of gene coding for expression of LETS to human chromosome 8, 5640

Homologous genes for enolase, phosphogluconate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome lp, 2382

X-linkage of human phosphoribosylpyrophosphate synthetase, 482 Chromosome, metacentric

Genes for immunoglobulin K and heavy chains assigned to chromosomes 6 and 12 in mouse, 4494

Chromosome, metaphase Co-transfer of human X-linked markers into murine somatic cells via

isolated metaphase chromosomes, 3346 Entrapment of metaphase chromosomes into phospholipid vesicles

(lipochromosomes): Carrier potential in gene transfer, 1361 Entrapment of metaphase chromosomes into phospholipid vesicles

(lipochromosomes): Carrier potential in gene transfer (correction), 3009

Chromosome, mouse Assignment of genes to regions of mouse chromosomes, 946 Chromosomal locations of mouse immunoglobulin genes, 2883 Fluorescent light-induced chromosome damage and its prevention in

mouse cells in culture, 1830 Fluorescent light-induced DNA crosslinkage and chromatid breaks in

mouse cells in culture, 3809 Genes for immunoglobulin K and heavy chains assigned to chromosomes

6 and 12 in mouse, 4494 Homologous genes for enolase, phosphogluconate dehydrogenase,


Location on chromosome I of Ronr, a gene that regulates renin in submaxillary gland of mouse, 5623

Negative control of hemoglobin production in somatic cell hybrids due to heme deficiency, 4354

Chromosome, polytene Cyclic GMP associated with gene expression of polytene chromosomes of

Drosophila melanogaster, 1480 Chromosome, sex

Evolution of Y chromosomes and dosage compensation, 5618 Chromosome, wheat

Influence of homoeologous chromosomes on gene-dosage effects in allohexaploid wheat (Triticum aestivum L.), 1446

Chromosome, yeast Chromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437 Spontaneous mitotic recombination occurs at the two-strand stage, 4436

Chymotrypsin (EC 3.4.21.1) Deacetylation of acetylchymotrypsin: Absence of evidence for an

intermediate, 172 Cilia

Polycationic macromolecules inhibit cilia-mediated ovum transport in rabbit oviduct, 4413





Circadian rhythm Comparison of synchronization of circadian corticosteroid rhythms by


photoperiod and food (correction), 3535 "Dark-active" rat transformed into "light-active" rat by destruction of

24-hr clock: Function of 24-hr clock and synchronizers, 6276 Existence of a yearly clock in surgically and self-blinded chipmunks,

3517 Neonatal suprachiasmatic nucleus ablation: Absence of functional and

morphological plasticity, 6243 Photoperiodic regulation of hamster testis: Dependence on circadian

rhythms, 1034 Circular dichroism

Actinomycin D-deoxynucleotide interactions: Binding isotherms at benzenoid and quinoid portions of the drug, 4729

Bacteriochlorophyll electronic transition moment directions in bacteriochlorophyll a-protein, 4920

Interaction of mycobacterial polymethylpolysaccharides with paranaric acid and palmitoyl-coenzyme A: Structural specificity and monomeric dissociation constants, 691

Ligandin retains and albumin loses bilirubin binding capacity in liver cytosol, 1213

Mononucleosome DNA conformation: Circular dichroism analysis, 4759 Physicochemical characterization of six monoclonal

cryoimmunoglobulins: Basis for cold-dependent insolubility, 3440 Two fragments from fibrinolysin digests of ovine prolactin:

Characterization and recombination to generate full immunoreactivity, 2155

Circular dichroism, magnetic Cluster characterization in iron-sulfur proteins by magnetic circular

dichroism, 5273 Citrus exocortis viroid


RNA sequences complementary to citrus exocortis viroid in nucleic acid preparations from infected Gynura aurantiaca, 896

Clark's Theorem Clark's Theorem on linear programs holds for convex programs, 1624

Clathrin Coated vesicles: Characterization, selective dissociation, and reassembly,

4394 Cline

Random genetic drift in a cline, 423 Clonal dominance

Clonal dominance: Loss and restoration in adoptive transfer, 1967 Clostridium pasteurianum

Rationale for stabilization of oxygen-labile enzymes: Application to a clostridial hydrogenase, 3640

Clover see Rhizobium trifolii

Cobalt Bond angles in transition metal tetracarbonyl compounds: Test of theory


theory of hybrid bond orbitals, 12 Cochlea

Synapses involving auditory nerve fibers in primate cochlea, 4582 Cochlear potential

Sound transmission in salamander ear, 529 Coelenterazine


Coenzyme Qlo Rescue by coenzyme Qlo from electrocardiographic abnormalities caused

by toxicity of adriamycin in rat, 5178 Cohomology

Unstable cohomology classes of SLn (Z), 43 Colcemid

Differences among 100-A filament subunits from different cell types, 4364

Colchicine Colchicine inhibits changes in amino acid transport and initiation of

DNA synthesis in regenerating rat liver, 1394 Relationship between dibutyryl cyclic AMP and microtubule

organization in contracting heart muscle cells, 319 Cole-Moore effect

Cole-Moore effect in the frog node, 3254 Colicin Ia

Colicin Ia: Effect on Escherichia coli proton electrochemical gradient, 2579

Colicin K Reduction of membrane potential, an immediate effect of colicin K, 2483

Collagen see also Procollagen Arterial collagen: Increased turnover in hypertensive rats, 451 Attachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408 Chemotactic attraction of human fibroblasts to type I, II, and III

collagens and collagen-derived peptides, 871 Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621 Collagen biosynthetic activities expressed in lymphocytic cells, 1379 Embryonic neural retina collagen: In vitro synthesis of high molecular

weight forms of type II plus a new genetic type, 3235 Fibronectin is the collagen receptor on platelet membranes, 5864

Subject Index 6357

Induction de novo of a gene product during heterologous epithelial-mesenchymal interactions in vitro, 2790

Lysyl oxidase: Biochemical and immunochemical study in experimental hepatic fibrosis in rat, 2945

Myoblast phenotype altered by dimethyl sulfoxide, 3826 Prolyl hydroxylase half reaction: Peptidyl prolyl-independent

decarboxylation of a-ketoglutarate, 2145 Recombinant bacterial plasmid constructed containing a chick pro-(Y2

collagen gene sequence, 5846 Collagenase

Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides, 871

Regulation of corneal collagenase production: Epithelial-stromal cell interactions, 4417

Collagenase (EC 3.4.24.3) Proteases induce secretion of collagenase and plasminogen activator by

fibroblasts, 1839 Colonic mucosa


Colony-stimulating factor Bone marrow colony-stimulating factor and tumor resistance-enhancing

activity of postendotoxin mouse sera, 2893 Combined immunodeficiency disease


Competing risk Dose-response curves and competing risks, 4087

Complement Autosomal locus regulates inverse relationship between sialic acid


Complement C3 convertase: Cell surface restriction of /lH control and generation of restriction on neuraminidase-treated cells, 2416

Complement lesion: Molecular nature, 5655 Electron spin resonance studies on interaction of complement proteins

with erythrocyte membranes, 4930 Initiation of alternative pathway of complement: Recognition of

activators by bound C3b and assembly of entire pathway from six isolated proteins, 3948

Membrane sialic acid on target particles modulates their phagocytosis by trypsin-sensitive mechanism on human monocytes, 3831

Membrane sialic acid regulates lIH-dependent decay-dissociation of amplification C3 convertase of alternative complement pathway, 1971

Murine complement component 3: Genetic variation and linkage to H-2, 963

Murine Ss protein: Ss protein is functionally the fourth component of complement, 2424

Specific antibody and Clq binding to hapten-sensitized lipid vesicles visualized, 3933

Specific antibody-dependent binding of complement component Clq to hapten-sensitized lipid vesicles, 1515

Specific C5a receptor demonstrated on intact human polymorphonuclear leukocytes, 3943

Tracer exchange across C5b-9 complement lesion in a biological membrane: Steady-state analysis, 5669

Two HLA-linked loci controlling the fourth component of human complement, 5165

Complex formation Formation of a ternary complex: Actimn, 5'-adenylyl imidodiphosphate,

and subfragments of myosin, 54 Computed tomography

Mathematical aspects of divergent beam radiography, 2055 Computer model

Computerized multidimensional scaling used to compare immunoelectron microscopy data with protein near-neighbor information: Application to 30S ribosome from Escherichia coli, 3128

Computer model-building Drug-nucleic acid interactions: Conformational flexibility at

intercalation site, 828 Computer simulation

Active site of bovine trypsin: Interactive computer surface graphics approach, 5409

Protein tertiary structure: Formation on a computer, 554 Regulation of self-renewal probability in Hydra stem cell clones, 886

Concanavalin A Changes in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818 Changes in three-dimensional structure of concanavalin A upon

, demetallization, 2286 Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with

fragment A from diphtheria toxin, 5319 Common ancestor for concanavalin A and lentil lectin? 1136 Diphtheria toxin has properties of a lectin, 261 Inhibition of growth and guanylate cyclase activity of undifferentiated

prostate adenocarcinoma by extract of balsam pear (Momordica charantia abbreviata), 989

Malaria merozoites isolated: Release of Plasmodium chabaudi merozoites from schizonts bound to immobilized concanavalin A, 5081

Phosphatidylserine: Interaction with mast cells, 4997 Suppressor cell activity altered in chronic active hepatitis, 1549 Transglutaminase activity in human lymphocytes: Early activation by

phytomitogens, 1157 Conditioned-medium factor

Neurite outgrowth induced by a conditioned-medium factor ,..und to culture substratum, 5210



6358 Subject Index

Conductance theory Paired ions: Dipolar pairs as subset of diffusion pairs, 16

Conductivity internal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548 Conformation

[Aspl,Ile5]- and [Phe4,Tyr8]angiotensin II: Correlation of biological activity and solution conformation, 3630

Chromatin subunit: Conformational changes, 660 Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669 Conformational change


Does irehdiamine kink DNA? 4286 Enmzyme-enzyme interactions: Unsymmetrical and concerted examples of

effect on steady-state enzyme kinetics, 1101 Glucose-induced conformational change in yeast hexokinase, 4848 Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276 Conformational energy

Model for hydration of peptides and its application to conformational analysis of terminally blocked amino acids and dipeptides, 5760

Congressional apportionment Congressional apportionment: Quota methods are still non-unique, 3537

Connective tissue Attachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408 Connective tissue matrix

Codistribution of pericellular matrix proteins in cultured fibroblasts and loss in transformation: Fibronectin and procollagen, 4944

Connectivity Connectivity as an alternative to boundary integral equations:

Construction of bases, 2059 Consanguinity

Inbreeding: Effect on IQ and mental retardation, 3906 Contact inhibition


Cooperativity Accumulation of a slowly dissociable peptide hormone binding

component by isolated target cells, 672 Cooperativity eliminated in aspartate transcarbamylase by nitration of

single tyrosine residue, 2654 Cooperativity in 02 binding to iron porphyrins, 1052 Insulin receptor: Interaction with nonreceptor glycoprotein from liver

cell membranes, 3070 Interacting enzyme systems at steady state: Further Monte Carlo

calculations on two-state molecules, 5260 Kinetics of hemoglobin and transition state theory, 2108 Model compounds for T state of hemoglobin, 564 Molecular field theory of reversible unfolding of biopolymers, 2755 Picosecond photodissociation and subsequent recombination processes in

carbon monoxide hemoglobin, 573 Pyruvate dehydrogenase multienzyme complex from Escherichia coli:

Mechanism of action, 4877 "Tension" on heme by proximal base and ligand reactivity: Conclusions

from model compounds for reaction of hemoglobin, 3747 Copper

see also Protein, copper Blue copper site in oxidized azurin characterized by extended x-ray

absorption fine structure: Determination of a short Cu-S distance, 4069

Coordination environment and fluoride binding of type 2 copper in the blue copper oxidase ceruloplasmin, 4078

Reductant-dependent electron distribution among redox sites of laccase, 5245

Tyrosinase from Neurospora crassa: Amino acid sequence, 3635 Copy number

ColEl-derived plasmid copy-number mutant: Isolation and characterization, 5869

Cornea Regulation of corneal collagenase production: Epithelial-stromal cell

interactions, 4417 Coronary vasodilator

Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: Comparison with prostacyclin and other prostanoids, 3522

Coronavirus Temperature-sensitive mutants of mouse hepatitis virus produce a high

incidence of demyelination, 4033 Corpus luteum

Corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of corpus luteum, 847

Corpus striatum Dopamine: Conformation at dopamine receptor, 2641

Corrections Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron

microscopic determination, 2054 Comparison of synchronization of circadian corticosteroid rhythms by

photoperiod and food, 3535 Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis, 6337 Differences in behavior and prognosis between leukemic and

lymphomatous forms of a transplantable hamster lymphocytic neoplasm induced by simian virus 40, 3535

Disulfide bond connecting the chains of ricin, 4067 Endorphins may function in heat adaptation, 4596


Energy conformation study of Met-enkephalin and its D-Ala2 analogue and their resemblance to rigid opiates, 6337

Entrapment of metaphase chromosomes into phospholipid vesicles (lipochromosomes): Carrier potential in gene transfer, 3009

Evidence from UV transcription mapping in HeLa cells that heterogeneous nuclear RNA is the messenger RNA precursor, 1043

Factor IX activated by reaction product of tissue factor and Factor VII: Additional pathway for initiating blood coagulation, 2539

Large Ti oligonucleotides of Moloney leukemia virus missing in env gene recombinant, HIX, are present on intracellular 21S Moloney viral RNA species, 5244

/-Lipotropin is major opioid-like peptide of human pituitary and rat pars distalis: Lack of significant /-endorphin, 5244

Local mutagenesis: Method for generating viral mutants with base substitutions in preselected regions of viral genome, 4596


5,3-Oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid, 5244

Regional dissociation of /-endorphin and enkephalin contents in rat brain and pituitary, 1608

Role of nucleotides in tubulin polymerization: Effect of guanylyl 5'-methylene diphosphonate, 1608

Site-specific initiation of a DNA fragment: Nucleotide sequence of bacteriophage G4 negative-strand initiation site, 6337

Solubilization of apolipoprotein B and its specific binding by cellular receptor for low density lipoprotein, 1043

Synthetic peptide derivatives that bind to fibrinogen and prevent polymerization of fibrin monomers, 5742

Triphosphate residues at the 5' ends of rRNA precursor and 5S RNA from Dictyostelium discoideum, 2539

Corticosteroid Comparison of synchronization of circadian corticosteroid rhythms by


photoperiod and food (correction), 3535 Corticosteroids: Action in regulation of prostaglandin biosynthesis in

cultured fibroblasts, 214 Corticotropin

Bacterial plasmids constructed that contain nucleotide sequence for bovine corticotropin-/-lipotropin precursor, 6021

Coordinate control of corticotropin, /-lipotropin, and /-endorphin release in mouse pituitary cell cultures, 4972

Corticotropin, lipotropin, and /-endorphin production by a human nonpituitary tumor in culture: Evidence for common precursor, 5160



/1-Lipotropin is major opioid-like peptide of human pituitary and rat pars distalis: Lack of significant /-endorphin (correction), 5244

Pro-opiocortin, a precursor to opioid peptides and corticotropin, 669 Corticotropin-inhibiting peptide

Corticotropin-inhibiting peptide from human pituitary glands: Isolation, characterization, and synthesis, 4306

Corticotropin-inhibiting peptide from human pituitary glands: Isolation, characterization, and synthesis (correction), 6337

Cortisol Thyroid and glucocorticoid hormones synergistically control growth

hormone mRNA in cultured GH1 cells, 45 Cosmology

Chronometric cosmology: Redshift--magnitude relatioin for quasi-stellar objects, 535

Coumermycin Antagonists of DNA gyrase inhibit repair and recombination of

UV-irradiated phage X, 4125 Creatine kinase (EC 2.7.3.2)


Myoblast phenotype altered by dimethyl sulfoxide, 3826 Creatine phosphate

31p nuclear mangetic resonance signals in brain detected by in vivo and freeze-trapped assays, 4925

Creatine phosphokinase see Creatine kinase

Creutzfeldt-Jakob disease Creutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsters

with reference to clinical syndromes and strains of agent, 3432 Unusual resistance to ionizing radiation of the viruses of kuru,

Creutzfeldt-Jakob disease, and scrapie, 6268 Creutzfeldt-Jakob virus


Cricket see Teleogryllus oceanicus

Critical micelle concentration Phosphatidylserine: Interaction with mast cells, 4997

Crotoxin Snake venoms: Search for relationships among hemolytic,

phospholipolytic, and neurotoxic activities, 600 Cryobiochemistry

Fe-02 bonding and oxyheme structure in myoglobin, 2291 Cryoimmunoglobulin

Physicochemical characterization of six monoclonal cryoimmunoglobulins: Basis for cold-dependent insolubility, 3440

Cryo-ultramicrotomy Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329




Crystal see also X-ray crystallography

Crystallin Aspartic acid racemization in heavy molecular weight crystallins and

water-insoluble protein from normal human lenses and cataracts, 1204 Diabetic cataract formation: Potential role of glycosylation of lens

crystallins, 2918 Crystal, liquid

Protein-lipid interactions in bilayer membranes: Theoretical study, 1616 Crystallography

see also X-ray crystallography Colored lattices, 5264 Rotatiomnal symmetry: Effect on colored lattices, 5751

Crystal structure Cholesterol monohydrate growth in model bile solutions, 6230 Crystal structures of o"-cerium phases, 1066 Joint probability distribution of invariants comprising determinantal

inequalities: Heuristic derivation, 2545 Structure determination of crystalline substances by diffraction

methods: Philosophic concepts and their implementation (Review), 3540

Cyanogen bromide ml Moloomey sarcoma virus pP60gag gene order: Unique peptides in

carboxy terminus of the polyprotein, 4694 Cyclic AMP

see Adenosine 3':5'-cyclic monophosphate 3':5'-Cyclic-AMP phosphodiesterase (EC 3.1.4.17)


Cyclic GMP see Guanosine 3':5'-cyclic monophosphate

3':5'-Cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) Mammalian protein kinase and phosphodiesterase activities inhibited by

a cyclic AMP-like compound isolated from higher plants, 4301 Cycloheximide

Cycloheximide resistance can be mediated through either ribosomal subunit, 3158


Cyclo-oxygenase see also Cycloxygenase; Prostaglandin synthase Corticosteroids: Action in regulation of prostaglandin biosynthesis in

cultured fibroblasts, 214 Cyclopenta[c,d]pyrene

Cyclopenta[c,dlpyrene: A highly mutagenic polycyclic aromatic hydrocarbon, 1667

Cyclophosphamide Induction of normal differentiation in myeloid leukemia cells in vivo,

3781 Cycloxygenase

see also Cyclo-oxygenase; Prostaglandin synthase lonophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Cysteine

Spin labeling of a cysteine residue of Escherichia coli outer membrane lipoprotein in its membrane environment, 127

Cytidine 3':5'-cyclic monophosphate phosphodiesterase Cytidine 3':5'-cyclic monophosphate phosphodiesterase activity

depressed in developing tissues of guinea pigs, 4422 Cytidine 5'-triphosphate

Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and of its complex with cytidine triphosphate, 5276

Cytochalasin B Differences among 100-A filament subunits from different cell types,

4364 Regulation of corneal collagenase production: Epithelial-stromal cell

interactions, 4417 Specificity of effects of cytochalasin B on transport and motile processes,

329 Cytochemistry

'y-Aminobutyric acid receptors visualized in spinal cord cultures by [3H]muscimol autoradiography, 6281

Cytochemical studies on GERL, provacuoles, and vacuoles in root meristematic cells of Euphorbia, 852


Cytochrome c Chromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437 Pseudomonas cytochrome c551 at 2.0 A resolution: Enlargement of

cytochrome c family, 2674 Cytochrome c oxidase (EC 1.9.3.1)

Cytochrome oxidase resolved into two component complexes, 5908 Cytochrome P-448

Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer of microsomal mixed-function monooxygenases, 682

Cytochrome P-450 Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955 Regio- and stereoselectivity of various forms of purified cytochrome

P-450 in metabolism in benzo[a]pyrene and (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA, 3123

Two forms of bovine erythrocyte cytochrome b5 are identical to segments of microsomal cytochrome b5, 3118

Cytochrome P-700 Photosynthetic unit size, carotenoids, and chlorophyll-protein

composition of Prochloron sp., a prokaryotic green alga, 2301

Subject Index 6359

Cytolysis Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A

methylation reaction essential to cytolysis, 6220 Cytoplasmic inheritance

Mitochondrial translation products: Variation associated with male-sterile cytoplasms in maize, 3841

Teratocarcinoma cells as vehicles for introducing specific mutant mitochondrial genes into mice, 5113

Tumorigenicity and its suppression in cybrids of mouse and Chinese hamster cell lines, 2358

Cytoplasmic polyhedrosis virus Biosynthesis of cytoplasmic polyhedrosis virus mRNA:

"Pretranscriptional capping", 1086 Cytoplasm, male-sterile

Mitochondrial translation products: Variation associated with male-sterile cytoplasms in maize, 3841

Cytoskeleton Different intermediate-sized filaments distinguished by

immumnofluorescence microscopy, 5034 Phosphorylation in vivo and in vitro of human histocompatibility

antigens (HLA-A and HLA-B) in carboxy-terminal intracellular domain, 6002


Cytotoxicity Attack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825 Cholesterol is a critical cellular component for T-lymphocyte

cytotoxicity, 5683 Cytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folate

cofactors and antagonism by methotrexate, 980 Differential desensitization of functional adrenergic receptors in normal


Diphtheria toxin has properties of a lectin, 261 H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur

in chimeric mice, 6207 Monoclonal antibody defining a stage-specific mouse embryonic antigen

(SSEA-1), 5565 Natural killing and antibody-dependent cellular cytotoxicity are

independent immune functions in Minnesota miniature swine, 5127 Secondary cytotoxic T lymphocytes induced by purified HLA-A and

HLA-B antigens reconstituted into phospholipid vesicles, 5688 Spontaneous and antibody-dependent cell-mediated cytotoxicity by

human T cell subpopulations, 5137

Dansylation Susceptibility to mitogens retained after direct dansylation of viable

human lymphocytes, 3766 Decamethonium

Decamethonium both opens and blocks endplate channels, 2994 Decarboxylation

2-Deoxyglucose catabolized by phagocytic leukocytes in presence of 12-0-tetradecanoyl phorbol-13-acetate, 5422

Defective interfering particle Electron microscopic heteroduplex analysis of "killer" double-stranded

RNA species from yeast, 4224 Nucleotide sequence homology at 3' termini of RNA from vesicular

stomatitis virus and its defective interfering particles, 3225 Sequence of a RNA templated by 3'-OH RNA terminus of defective

interfering particles of vesicular stomatitis virus, 4704 Dehydration

Discrete length classes of DNA depend on mode of dehydration, 710 Demyelinating diseases

Degradation of basic protein in myelimn by neutral proteases secreted by stimulated macrophages: Possible mechanism of inflammatory demyelination, 1554

Demyelination Temperature-sensitive mutants of mouse hepatitis virus produce a high

incidence of demyelination, 4033 I)eoxyadenosine triphosphate

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency, 472

Deoxyribonuclease I Bacterial elongation factor Tu: Novel properties, 1250 Butyrate suppression of histone deacetylation leads to accumulation of


Hemoglobin switching in sheep: Only the y gene is in active conformation in fetal liver but all the f3 and y genes are in active conformation in bone marrow, 5884

Deoxyribonuclease I (EC 3.1.4.5) Compact oligomers and nucleosome phasing, 3583

Deoxyribonuclease II (EC 3.1.4.6) Acetylated histone H4 is preferentially associated with template-active

chromatin, 3574 Deoxyribonuclease, recBC

Phage repressor inactivated in a permeable cell system: Role of recBC DNase in induction, 3569

Deoxyribonucleic acid see also Hybridization, ribonucleic acid-deoxyribonucleic acid; Nucleic

acid Decomposition of linking number of a closed ribbon: Problem from

molecular biology, 3557 Distamycin-DNA and netropsin-DNA complexes: Conformational

features by Raman spectroscopy, 5483



6360 Subject Index

Sugar pucker geometries at intercalation site of propidium diiodide into miniature RNA and DNA duplexes in solution, 2553

Deoxyribonucleic acid, bacterial Complementary sequences 1700 nucleotides apart form ribonuclease III

cleavage site in Escherichia coli ribosomal precursor RNA, 3593 DNA sequence of araBAD promoter in Escherichia coli B/r, 4724 Early events and mechanisms in induction of bacterial SOS functions:

Analysis of phage repressor inactivatioin process in vivo, 1657 Deoxyribonucleic acid, bacteriophage

Analysis of dOX DNA replication cycle by electron microscopy, 605 Bacteriophage \ repressor: Interaction with nonoperator DNA containing

single-strand gaps, 5817 Determination of capsid size by satellite bacteriophage P4, 400 Discrete length classes of DNA depend on mode of dehydration, 710 Enzymatic breakage of cohesive end site of phage X DNA: Terminase

(ter) reaction, 4199 Homology-dependent cutting in trans of DNA in extracts of Escherichia

coli: Approach to enzymology of genetic recombination, 620 Intracellular development of bacteriophage X, with special reference to

DNA packaging, 3206 Symmetry mismatch and DNA packaging in large bacteriophages, 4779

Deoxyribonucleic acid base analysis Modification of DNA by the benz[a]pyrene metabolite diol-epoxide

r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 415 Deoxyribonucleic acid, chicken

Endogenous viral genes of White Leghorn chicken: Common site of residence and sites associated with specific phenotypes of viral gene expression, 5941

Ovalbumin gene: Structural sequences in native chicken DNA are not contiguous, 2205

Deoxyribonucleic acid cleavage ATP-induced conformational changes in restrictioln endonuclease from

Escherichia coli K-12, 3099 Deoxyribonucleic acid, complementary

Abnormal cellular localization of thyroglobulin mRNA associated with hereditary congenital goiter and thyroglobuliin deficiency, 74


Complex population of mRNA sequences in large polyadenylylated nuclear RNA molecules, 5544

Construction and characterization of 2.5-kilobase procollagen clone, 5417 Nucleotide sequences related to transforming gene of avian sarcoma

virus are present in DNA of uninfected vertebrates, 4102 Organization of immunoglobulin heavy chain genes and allelic deletion

model, 2140 Sodium pyrophosphate inhibition of RNA.DNA hybrid degradation by

reverse transcriptase, 5329 Deoxyribonucleic acid, damage

Bleomycin: Interaction with DNA, 5983 Fluorescent light-induced DNA crosslinkage and chromatid breaks in

mouse cells in culture, 3809 Nucleotide specificity in DNA scission by neocarzinostatin, 3603 Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608 Deoxyribonucleic acid degradation

Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of associated DNA sequences, 2239

Deoxyribonucleic acid, extrachromosomal Small circular DNAs: Change in quantity and size distribution during

development of chicken bursa, 5855 Deoxyribonucleic acid gyrase

Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage X, 4125

DNA gyrase: Subunit structure and ATPase activity of purified enzyme, 5960

Energy coupling in DNA gyrase and mechanism of action of novobiocin, 4838

Micrococcus luteus DNA gyrase: Active components and model for its supercoiling of DNA, 2098

Purification of subunits of Eschlerichia coli DNA gyrase and reconstitution of enzymatic activity, 1773

Deoxyribonucleic acid helix-destabilizing protein Exposure of DNA bases induced by interaction of DNA and calf thymus

DNA helix-destabilizing protein, 4689 Deoxyribonucleic acid, human

Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders, 1222

Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367 Duplicated human cY globin genes lie close together in cellular DNA, 5950

Deoxyribonucleic acid in chromatin DNA in chromatin: Possibility of nonkinked packing, 103

Deoxyribonucleic acid initiation Escherichia coli dnaB mutant defective in DNA initiation: Isolation and

properties of dnaB protein, 799 Deoxyribonucleic acid, intragenic spacer

Intragenic DNA spacers interrupt the ovalbumin gene, 1299 Deoxyribonucleic acid, macronuclear

Highly repetitious inverted terminal repeat sequence from Oxytricha macronuclear DNA: Isolation and characterization, 2626

Deoxyribonucleic acid, mammalian Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is

independent of amount of bromouracil in DNA, 4982 Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896 Infectious murine leukemia virus from DNA of virus-negative AKR

mouse embryo cells, 5539 Intervening sequence of DNA identified in structural portion of a mouse

/1-globin gene, 725


Leukemia in AKR mice: Defined suppressor cell population expressing membrane-associated DNA, 6211

Principal aflatoxin B1-DNA adduct formed in vivo in rat liver: Identification, 1745

Deoxyribonucleic acid, methylation cro rotein of bacteriophage X: Mechanism of action, 1783 Recognition site of Escherichia coli B restriction enzyme on oXsBI and

simian virus 40 DNAs: Interrupted sequence, 2271 Translocation of DNA sequences during sea urchin embryogenesis, 5627

Deoxyribonucleic acid, mitochondrial Cytoplasmic transfer of resistance to antimycin A in Chinese hamster

cells, 5604 Displacement-loop replication initiation sequence in animal

mitochondrial DNA exists as a family of discrete lengths, 677 EcoRI cleavage site variants of mitochondrial DNA molecules from rats,

909 Human mitochondrial DNA: Analysis of 7S DNA from origin of

replication, 735 Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation and

characterization, 3268 Replication in mitochondrial DNA molecules from Drosophila

melanogaster: Origin and direction, 3886 Deoxyribonucleic acid modification


Deoxyribonucleic acid nucleotidyltransferase DNA polymerase activities in differentiating mouse neuroblastoma N-18

cells, 1289 Herpesvirus-specific DNA polymerase isolated from tissues of an

American patient with Burkitt lymphoma, 4504 Highly repetitious inverted terminal repeat sequence from Oxytricha

macronuclear DNA: Isolation and characterization, 2626 Mutagenesis during in vitro DNA synthesis, 1924 Rous sarcoma viral RNA translation inhibited by a specific

oligodeoxyribonucleotide, 285 Deoxyribonucleic acid nucleotidyltransferase (EC 2.7.7.7)

Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in vitro DNA synthesis on irradiated templates, 3037

Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid-dependent Biosynthesis of reverse transcriptase from Rauscher murine leukemia

virus by synthesis and cleavage of a gag-pol read-through viral precursor polyprotein, 2016

3'-Terminal nucleotide sequence of encephalomyocarditis virus RNA determined by reverse transcriptase and chain-terminating inhibitors, 4257

Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid-dependent (EC 2.7.7.7)

Normal human placentas contain RNA-directed DNA polymerase activity like that in viruses, 6263

Sodium pyrophosphate inhibition of RNA.DNA hybrid degradation by reverse transcriptase, 5329

Deoxyribonucleic acid overproducer ColEl-derived plasmid copy-number mutant: Isolation and

characterization, 5869 Deoxyribonucleic acid, plasmid

In vitro system from Escherichia coli that catalyzes generalized genetic recombination, 3698

Mutagenesis of a circular DNA molecule in vitro by using synthetic restriction sites, 6012

Plasmid-encoded protein required for replication in vitro of plasmid R6K, 5381

Deoxyribonucleic acid plastid Maize plastid gene expressed during photoregulated development, 3060

Deoxyribonucleic acid polymerase see Deoxyribonucleic acid nucleotidyltransferase

Deoxyribonucleic acid, protozoan Macronuclear DNA of the hypotrichous ciliate Oxytricha fallax, 4992

Deoxyribonucleic acid, pyrimidine-purine Unique structures formed by pyrimidine-purine DNAs which may be

four-stranded, 1637 Deoxyribonucleic acid, reassociated repetitive

Higher derivative techniques applied to analysis of high-resolution thermal denaturation profiles of reassociated repetitive DNA, 6026

Deoxyribonucleic acid, recombinant see also Hybridization, molecular; Molecular cloning; Recombination,

genetic Bacterial clone synthesizing proinsulin, 3727 Bacterial plasmids constructed that contain nucleotide sequence for

bovine corticotropin-/3-lipotropin precursor, 6021 Bacteriophage X carrying the Escherichia coli chromosomal region of

replication origin, 5099 Bacteriophage P1 immunity analyzed by using X-P1 recombinants

constructed in vitro, 5594 Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936 Chromosomal integration of phage X by a DNA insertion element, 1490 Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367 Cloned mouse n- and /-globin genes: Conservation of intervening

sequence locations and extragenic homology, 6187 Cloned single repeating units of 5S DNA direct accurate transcription of

5S RNA when injected into Xenopus oocytes, 2849 Construction and characterization of 2.5-kilobase procollagen clone, 5417 Construction and properties of chimeric plasmids in Bacillus subtilis,

1428 Contacts between Escherichia coli RNA polymerase and a lac operon

promoter, 5314 DNA clones containing mouse immunoglobulin h chain genes isolated by

in vitro packaging into phage A coats, 4709 DNA cloning in Bacillus subtilis, 1433




Eukaryotic tRNA genes: Specific transcription in Xenopus germinal vesicle extracts, 4819

Excision of DNA segments introduced into cloning vectors by poly(dA.dT) joining method, 1763

Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5) controlled by a bacterial insertion element (IS2), 6172

Immunoglobulin light chain mRNA is processed from large nuclear RNA, 342


Mechanism of integrating foreign DNA during transformation of Bacillus subtilis, 3664

Molecular cloning of genetically active fragments of Bacillus DNA in Bacillus subtilis and properties of vector plasmid pUBlIO, 1423

Phenotypically cryptic EcoRI endonuclease activity specified by ColEl plasmid, 1265


Transduction of a bacterial gene into mammalian cells, 2117 Variable and constant regions are separated in 10-kbase transcription

unit coding for immunoglobulin K light chains, 6044 Deoxyribonucleic acid, reiterated

Polycyclic aromatic hydrocarbons: Dose-dependent preferential binding to reiterated DNA of murine skin cells in cultture, 5841

Deoxyribonucleic acid-relaxing enzymes DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for a

nuclear factor, 4873 Deoxyribonucleic acid repair

Carcinogens enhance survival of UV-irradiated simian virus 40 in treated moinkey kidney cells: Induction of a recovery pathway? 346

Cell-free assay measuring repair DNA synthesis in human fibroblasts, 1887

Depurinated DNA repaired in vitro by enzymes purified from human lymphoblasts, 794

Genetic recombination in Escherichia coli treated with psoralen and light: Topography and kinetics, 2373

Herpes simplex virus: Ultraviolet reactivation is mutagenic and inducible in mammalian cells, 2378



Reconstitution of Escherichia coli repair endonuclease activity from separated uvrA+ and uvrB+.uvrC+ gene products, 2569

Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation, 1984

X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma, 3962

Deoxyribonucleic acid replication Actinomycin D inhibits initiation of DNA replication in mammalian

cells, 6088 Alternative structure for DNA: Implications, 4092 Analysis of OX DNA replication cycle by electron microscopy, 605 Assembly of new nucleosomal histones and new DNA into chromatin,

2130 Construction of plasmid-phage hybrid: Use of hybrid to demonstrate

ColEl DNA replication in uivo in absence of ColEl-specified protein, 2200

Diadenosine 5',5"'-P1,P4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells, 371

DNA intermediates at Escherichia coli replication fork: Effect of dUTP, 238

DNA polymerase activities in differentiating mouse neuroblastoma N-18 cells, 1289

Exposure of DNA bases induced by interaction of DNA and calf thymus DNA helix-destabilizing protein, 4689


Local mutagenesis: Method for generating viral mutants with base substitutions in preselected regions of viral genome (correction), 4596

Nucleotide sequences of separate origins of synthesis of bacteriophage G4 viral and complementary DNA strands, 1081

Origin of DNA replication in papovavirus chromatin is recognized by endogenous endonuclease, 5964

Phage Mu-l integration: Nalidixic acid treatment causes clustering of Mu-1-induced mutations near replication origin, 4940


Purified simian virus 40 T antigen proteins: Biological activity, 1279 RNA transcribed from DNA at origin of phage fd single strand to -

replicative form conversion, 645 Site-specific initiation of a DNA fragment, 1652 Site-specific initiation of a DNA fragment: Nucleotide sequence of

bacteriophage G4 negative-stramnd initiation site, 3094 Site-specific initiation of a DNA fragment: Nucleotide sequence of

bacteriophage G4 negative-strand initiation site (correction), 6337 Strand-specific break near origin of bacteriophage P2 DNA replication,

1685 Structure of origin of DNA replication of bacteriophage fd, 50 Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro,

4291 Time of recombination in Drosophila melanogaster oocyte: Evidence

from a temperature-sensitive recombination-deficient mutant, 3351 Uracil incorporation: Source of pulse-labeled DNA fragments in

replication of Escherichia coli chromosome, 233 Deoxyribonucleic acid, replicative form

Structure of nascent replicative form DNA of coliphage M13, 153

Subject Index 6361

Deoxyribonucleic acid, satellite Correlation between phosphorylated HI histones and satellite DNAs in

Drosophila virilis, 866 Gene adjacent to satellite DNA in Drosophila melanogaster, 5898

Deoxyribonucleic acid sequence see also Nucleotide sequence DNA sequence of araBAD promoter in Escherichia coli B/r, 4724 DNA sequences amplified during chicken cartilage and neural retina

differentiation, 4451 Intervening sequence of DNA identified in structural portion of a mouse

/-globin gene, 725 Polymorphism of DNA sequence adjacent to human /-globin structural

gene: Relationship to sickle mutation, 5631 Single base-pair change creates a Chi recombinational hotspot in

bacteriophage X, 96182 Structure of yeast phenylalanine-tRNA genes: Intervening DNA segment

within region coding for tRNA, 190 Translocation of DNA sequences during sea urchin embryogenesis, 5627

Deoxyribonucleic acid structure Alternative structure for DNA: Implications, 4092 Does irehdiamine kink DNA? 4286 How many base-pairs per turn does DNA have in solution and in

chromatin? Theoretical calculations, 640 Transient electric dichroism of rod-like DNA molecules, 195

Deoxyribonucleic acid, supercoiled DNA gyrase: Subunit structure and ATPase activity of purified enzyme,

5960 DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for a

nuclear factor, 4873 DNA superhelices in solution: Model, 1708 Energy coupling in DNA gyrase and mechanism of action of novobiocin,

4838 Histone packing in nucleosome core particle of chromatin, 3649 Micrococcus luteus DNA gyrase: Active components and model for its

supercoiling of DNA, 2098 Deoxyribonucleic acid synthesis

see also Oligonucleotide synthesis Animal cells reversibly permeable to small molecules, 351 Bacteriophage T7 DNA: Marker rescue and partial replication, 6144 Colchicine inhibits changes in amino acid transport and initiation of

DNA synthesis in regenerating rat liver, 1394 DNA synthesis induced in terminally differentiated myotubes by

activation of src gene of Rous sarcoma virus, 5501 DNA synthesis in growing BALB/c 3T3 mouse cells controlled by a

fibroblast growth regulatory factor, 6115 Efficient correction of a mutation by use of chemically synthesized DNA,

4268 Epidermal growth factor: Biological activity requires persistent

occupation of high-affinity cell surface receptors, 5788 HeLa cell DNA synthesis: Initiation in a subnuclear system, 5931 Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057 Inducers of DNA synthesis present during mitosis of mammalian cells

lacking G1l and G2 phases, 5043 Inhibition of growth and guanylate cyclase activity of undifferentiated

prostate adenocarcinoma by extract of balsam pear (Mornmordica charantia abbreviata), 989


Magnesium reverses inhibitory effects of calcium deprivation on coordinate response of 3T3 cells to serum, 4379



Mutagenesis during in vitro DNA synthesis, 1924 Nucleosomes associated with newly replicated DNA have altered

conformation, 2717 Ordered sequence of events is required before BALB/c-3T3 cells become

committed to DNA synthesis, 2839 Rate of macromolecular synthesis through cell cycle of Saccharomyces

cerevisiae, 4384 Sodium pyrophosphate inhibition of RNA-DNA hybrid degradation by

reverse transcriptase, 5329 Steroid hormones mediate reversible phenotypic transition between

transformed and untransformed states in mouse fibroblasts, 2805 Thioredoxin induced by bacteriophage T4: Three-dimensional structure,

5827 Uracil incorporation into nascent DNA of thymine-requiring mutant of

Bacillus subtilis 168, 2195 Deoxyribonucleic acid, Tetrahymena

Tetrahymena macronuclear DNA: Viscoelastic studies, 5062 Deoxyribonucleic acid, thermal denaturation

Higher derivative techniques applied to analysis of high-resolution thermal denaturation profiles of reassociated repetitive DNA, 6026

Deoxyribonucleic acid topoisomerase DNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA

topoisomerase, restriction endonuclease, and unique DNA endonuclease on plasmid and plant DNA, 4097

Deoxyribonucleic acid transfection Transfection of Fv-l permissive and restrictive mouse cells with

integrated DNA of murine leukemia viruses, 1451 Deoxyribonucleic acid transfer

Transfer of duck cell DNA sequences to nucleus of 3T3 cells by Rous sarcoma virus, 4252

Deoxyribonucleic acid unwinding DNA unwinding induced by photoaddition of psoralen derivatives and

determination of dark-binding equilibrium constants by gel elot.ronhoremsis. 270n.



6362 Subject Index

Deoxyribonucleic acid, viral Adenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175 BK virus DNA: Cleavage map and sequence analysis, 2150 DNAs of simian virous 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073 Endogenous type C virus activated in BALB/c mouse cells by

herpesvirus DNA, 4558 Endogenous viral genes of White Leghorn chicken: Common site of

residence and sites associated with specific phenotypes of viral gene expression, 5941


Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: Large specific deletion occurring at high frequency during circularization, 2112

Molecular genetics of herpes simplex virus: Regions of obligatory and nonobligatory identity within diploid regions of genome demonstrated by sequence replacement and insertion, 3896

Mtv-2 gene responsible for early appearance of mammary tumors in GR mouse by nucleic acid hybridization, 2368

Nucleotide sequences around origin of DNA replication similar in mouse polyoma virus and simian virus 40, 162

"Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694 Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro,

4291 Vaccinia virus DNA: Visualization of an inverted terminal repetition,

4863 Deoxyribonucleoside


Deoxyuridine, bromo- Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is

independent of amount of bromouracil in DNA, 4982 DNA polymerase activities in differentiating mouse neuroblastoma N-18

cells, 1289 DNA sequences amplified during chicken cartilage and neural retina

differentiation, 4451 Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896 Deoxyuridine, fluoro-

Cytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folate cofactors and antagonism by methotrexate, 980

Deoxyuridine, iodo- Infectious murine leukemia virus from DNA of virus-negative AKR

mouse embryo cells, 5539 Deoxyuridinetriphosphatase (EC 3.6.1.23)


Uracil incorporation: Source of pulse-labeled DNA fragments in replication of Escherichia coli chromosome, 233

Deoxyuridine 5'-triphosphate DNA intermediates at Escherichia coli replication fork: Effect of dUTP,

238 Derepression

Collagen biosynthetic activities expressed in lymphocytic cells, 1379 Desmin

Membrane sites in glycerinated chicken skeletal muscle fibers: Fluorescent localization and relationship to protein composition of Z disc, 3683

Destriau effect Electric double layer dynamics by high-field electroluminescence in

aqueous solution (Destriau effect), 2549 Detergent

Affinity purification of cardiac adenylate cyclase: Dependence on prior hydrophobic resolution, 59

Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effects . on liver surface membrane lipid structure and function, 4130

Contraction of detergent-treated smooth muscle, 3527 Human (HLA-A and HLA-B) and murine (H-2K and H-2D)



Determinantal inequality Joint probability distribution of invariants comprising determinantal

inequalities: Heuristic derivation, 2545 Detoxification

Regio- and stereoselectivity of various forms of purified cytochrome P-450 in metabolism in benzo[a]pyrene and (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA, 3123

Dexamethasone Acceleration of rate of elongation of tyrosine aminotransferase nascent

chains by dibutyryl cyclic AMP, 140 Cholesterol biosynthesis in HeLa S3G cells regulated by serum


Dexamethasone inhibition of plasminogen activator in rat hepatoma cells, 6130

Dexamethasone modulates binding and action of epidermal growth factor in serum-free cell culture, 1882

Dextran-estradiol conjugate Soluble biospecific macromolecule for purification of estrogen receptor,

3143 Diabetes

Albumin production rates and albumin mRNA levels correlated in livers of normal, diabetic, and insulin-treated diabetic rats, 5879



Protein degradation in diabetes and starvation, 2093 Thyrotropin-releasing hormone: High concentration in pancreatic islets,

4265 Diacylglycerol lipase (EC 3.1.1.34)

Formation of high density lipoprotein2-like particles during lipolysis of very low density lipoproteins in vitro, 4519

Diadenosine tetraphosphate Diadenosine 5',5"'-P1,P4-tetraphosphate triggers initiation of in vitro

DNA replication in baby hamster kidney cells, 371 Diamagnetic anisotropy

Diamagnetic anisotropy and orientation of (Y helix in frog rhodopsin and meta II intermediate, 5471

Diamagnetic anisotropy in proteins: Structural origins, 5475 Dictyostelium discoideum


Triphosphate residues at 5' ends of rRNA precursor and 5S RNA from Dictyostelium discoideum, 740

Triphosphate residues at the 5' ends of rRNA precursor and 5S RNA from Dictyostelium discoideum (correction), 2539

Dicyclohexylcarbodiimide Bioenergetics and glycolysis in anaerobic Escherichia coli cells: 31p

nuclear magnetic resonance studies, 2244 Membrane moiety of the H+-ATPase complex resolved into two kinds of

subunits, 4219 Dielectric dispersion

Electronic properties of some protein-methylglyoxal complexes, 315 Dielectric effect

Enzyme catalysis: Energetics, 5250 Diet

see also Malnutrition; Nutrition; Starvation Diet, genetics, and mental retardation imnteraction between

phenylketonuric heterozygous mother and fetus to produce nonspecific diminution of IQ: Support of justification hypothesis, 1562

Immunologic function and renal disease in (NZB x NZW)F1 mice: Influence of dietary restriction, 1500

Protein deficiency and energy restriction in young cebus monkeys, 1600 T-cell helper function: Regeneration in zinc-deficient adult mice, 5660

Diethylstilbestrol Estrogenic activity in vivo and in vitro of some diethylstilbestrol

metabolites and analogs, 468 Differentiation


Differentiation, cell Adrenergic differentiation of cells of cholinergic ciliary and Remak

ganglia in avian embryo after in vivo transplarntation, 2030 Age-dependent relaxation of gene repression: Increase of endogenous

murine leukemia virus-related and globin-related RNA in brain and liver of mice, 4431


Changes in genome composition of Friend virus complex in erythroleukemia cells during differentiation induced by dimethyl sulfoxide, 3278

Chimeric mice derived from human-mouse hybrid cells, 1914 Control of proliferation and differentiation in B lymphocytes by anti-Ig

antibodies amnd a serum-derived cofactor, 2401 Differential desensitization of functional adrenergic receptors in normal



DNA sequences amplified during chicken cartilage and neural retina differentiation, 4451



Induction of murine erythroleukemia differentiation by actinomyciin D, 2795


In vitro differentiation of a fast Na+ conductance in embryonic heart cell aggregates, 2776

Lengthening of G1 phase is not strictly correlated with differentiation in Friend erythroleukemia cells, 3813


Myoblast phenotype altered by dimethyl sulfoxide, 3826 Ovarian ornithine decarboxylase regulation in immature, pubescent, and

pseudopregnant rat, 2530 5,8-Oxyretinoic acid isolated from small intestine of vitamin A-deficient

rats dosed with retinoic acid, 2603 5,3-Oxyretinoic acid isolated from small intestine of vitamin A-deficient

rats dosed with retinoic acid (correction), 5244 Parathyroid hormone- and calcitonin-activated adenylate cyclases:


Proliferative capacity of murine hematopoietic stem cells, 490 Regulation of self-renewal probability in Hydra stem cell clones, 886 RNA synthesis-dependent and -independent pathways in stimulation of

neurite outgrowth by nerve growth factor, 6059 Segregation of different cell lines in vitro with neuronal and glial

properties from stem cell line of rat neurotumor RT4, 63)05 Stage-specific polypeptides synthesized during murine preimplantation

development: Identification, 3332




Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds, 2458

THY-i: Differentiation marker of potential mammary myoepithelial cells in vitro, 6093

Translocation of DNA sequences during sea urchin embryogenesis, 5627 Differentiation, mathematical

Differentiation in lacunary directions, 1060 Diffraction

see also X-ray diffraction Structure determination of crystalline substances by diffraction


Diffusion see also Electrodiffusion Calcium affects structure and function of hyaluronic acid matrix:

Carbon-13 nuclear magnetic resonance analysis and diffusional behavior of small solutes, 2261

Fluorescence energy transfer in the rapid-diffusion limit, 5746 Lateral diffusion coefficients of hormone-receptor complexes of insulin

and epidermal growth factor on plasma membrane of cultured fibroblasts: Quantitative determination, 5353

Photochemical technique for measuring lateral diffusion of spin-labeled phospholipids in membranes, 4661

RNA transport from isolated rat liver nuclei: Activation energy, 5400 Spatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313 Tracer exchange across C5b-9 complement lesion in a biological

membrane: Steady-state analysis, 5669 Dihydroalprenolol

Differential desensitization of functional adrenergic receptors in normal and malignant myeloid cells: Relationship to receptor-mediated hormone cytotoxicity, 1805

Dihydrofolate reductase see also Tetrahydrofolate dehydrogernase Evolution of /-galactosidase, 113

5a-Dihydrotestosterone Protein factor that inhibits binding and promotes release of

androgen-receptor complex from nuclear chromatin, 5969 Dimethyl sulfate

Amino-terminal fragment of lac repressor binds specifically to lac operator, 5851

Contacts between Escherichia coli RNA polymerase and a lac operon promoter, 5314

Dimethyl sulfoxide Changes in genome composition of Friend virus complex in


Co-transfer of human X-linked markers into murine somatic cells via isola'ted metaphase chromosomes, 3346



Myoblast phenotype altered by dimethyl sulfoxide, 3826 Terminal differentiation of human promyelocytic leukemia cells induced

by dimethyl sulfoxide and other polar compounds, 2458 Dinitrophenyl


Dinoflagellate Photosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801 Dioxetanone

Bioluminescence of firefly: Key steps in formation of electronically excited state for model systems, 30

Dipeptidyl carboxypeptidase see Peptidyl dipeptidase

Diphenylhexatriene Tramnslocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076 Discrete space

Pompeiu's problem on discrete space, 3555 Dispersal

Dispersal in relation to carrying capacity, 2854 Distamycin

Distamycin-DNA and netropsin-DNA complexes: Conformational features by Raman spectroscopy, 5483

Disulfide Disulfide-linked high molecular weight protein associated with human

cataract, 3244 Dogfish

see Mustelus canis Dolichol

Oligosaccharides coontaining glucose and mannose in glycoproteins of thyroid gland, 1162

Dopa ['F]Fluoro-dopa, an analogue of dopa, and its use in direct external

measurements of storage, degradation, and turnover of intracerebral dopamine, 464

Dopamine see also Receptor, dopamine Dopamine: Conformation at dopamine receptor, 2641 ImF]Fluoro-dopa, an analogue of dopa, and its use in direct external


Multiple receptors for brain dopamine, 1153

Subject Index 6363


Ontogenetic development of kainate neurotoxicity: Correlates with glutamatergic innervation, 2025


Dopamine ,-hydroxylase see Dopamine /-monooxygenase

Dopamine ,-monooxygenase (EC 1.14.17.1) Central noradrenergic neurons visualized in thick sections by unlabeled

antibody method: Transmitter-specific Golgi image, 2502 Dose-response curve

Dose-response curves and competing risks, 4087 Drell-Yan parton model

Failure of Drell-Yan parton model to account for production of J/'in nucleon-nucleon interactions, 5770

Drosophila Drosophila mutant with a temperature-sensitive block in nerve

conduction, 4047 Drosophila melanogaster

ADHS electromorph of Drosophila melanogaster: Structural analysis, 5609

Cyclic GMP associated with gene expression of polytene chromosomes of Drosophila melanogaster, 1480

Ecdysone-inducible functions of larval fat bodies in Drosophila, 5570 Ecdysteroid receptor in a cultured cell line of Drosophila melanogaster,

6035 Ecdysteroid receptors in imaginal discs of Drosophila melanogaster,

6039 /1-Galactosidase is induced by hormone in Drosophila melanogaster cell

cultures, 6102 Gene adjacent to satellite DNA in Drosophila melanogaster, 5898 Genetic dissection of short-term and long-term facilitation at Drosophila

neuromuscular junction, 515 Genetic regulation of tissue-specific expression of amylase structural

genes in Drosophila melanogaster, 4446 In vitro transcription of heat-shock-specific RNA from chromatiln of

Drosophila melanogaster cells, 759 Replication in mitochondrial DNA molecules from Drosophila

melanogaster: Origin and direction, 3886 Sequence organization and transcription at two heat shock loci in

Drosophila, 5613 Structure of psoralen-crosslinked ribosomal RNA from Drosophila

melanogaster, 1642 Time of recombination in Drosophila melanogaster oocyte: Evidence

from a temperature-sensitive recombination-deficient mutant, 3351 Drosophila miranda


Drosophila mojavensis Structural flexibility of isozyme variants: Genetic variants in Drosophila

disguised by cofactor and subunit binding, 395 Drosophila pseudoobscura

Genetic variation at a highly polymorphic esterase locuts in Drosophila pseudoobscura, 5090

Drosophila simulans Sequence organization and transcription at two heat shock loci in

Drosophila, 5613 Drosophila virilis

Correlation between phosphorylated Hi histones and satellite DNAs in Drosophila virilis, 866

Drought Messenger RNA is conserved dulring drying of drought-tolerant moss

Tortula ruralis, 842 Drug

see also Transport, drug; specific drugs Drug binding


Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: Calorimetric and spectroscopic binding studies, 3201

Drug delivery Preparation of liposomes with large internal aqueous space and high

capture by reverse-phase evaporation, 4194 Drug dependence

Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice, 4573

Drug intercalation Actinomycin D-deoxynucleotide interactions: Binding isotherms at

benzenoid and quinoid portions of the drug, 4729 Drug-nucleic acid interactions: Conformational flexibility at

intercalation site, 828 Sugar pucker geometries at intercalation site of propidium diiodide into

miniature RNA and DNA duplexes in solution, 2553 Drug, neuroleptic

Multiple receptors for brain dopamine, 1153 Drug, psychotropic

Benzodiazepine binding: Competitive inhibition by fractions from porcine brain, 6319

Dynamic light scattering Temperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325 Dynein


Dytiscus marginalis Transcription patterns of amplified Dytiscus genes coding for ribosomal

RNA after injection into Xenopus oocyte nuclei, 3791



6364 Subject Index

Early blight disease Reaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935 Ecdysone

Ecdysone-inducible functions of larval fat bodies in Drosophila, 5570 Ecdysteroid receptor in a cultured cell line of Drosophila melanogaster,


6039 Ecdysterone

/-Galactosidase is induced by hormone in Drosophila melanogaster cell cultures, 6102

Ecology Dispersal in relation to carrying capacity, 2854 Does environmental variability limit niche overlap? 5085 Geometric model describing quasi-equilibrium of energy flow in

populations of stream insects, 381 Ectoderm, embryonic

High molecular weight cell surface glycoprotein (LETS protein) expressed by preimplantation mouse embryos and teratocarcinoma stem cells, 2324

Egg laying hormone Neuronal interaction mediated by behaviorally active peptide, 5732

Eicosatetraynoic acid lonophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Ektacytometer


Elastic property Brillouin light scattering measurement of elastic properties of aligned

multilamella lipid samples, 1792 Electrical gating mechanism

Ligand-promoted transfer of proteins between phases: Spontaneous and electrically helped, 779

Electric dichroism Does irehdiamine kink DNA? 4286 Transient electric dichroism of rod-like DNA molecules, 195

Electrocardiograph Rescue by coenzyme Qlo from electrocardiographic abnormalities caused

by toxicity of adriamycin in rat, 5178 Electrochemical potential


Electrochemistry Siderophore electrochemistry: Relation to intracellular iron release

mechanism, 3551 Electrodiffusion

Ion flow through a membrane: Concentration and current responses to a step potential change, 1612

Ion flow through a membrane: Effect of chemical reaction on time dependence, 2064

Electroencephalogram /1-Endorphin induces nonconvulsive limbic seizures, 5221

Electrolyte model Paired ions: Dipolar pairs as subset of diffusion pairs, 16

Electromagnetic field Ionic factors in release of 45Ca2+ from chicken cerebral tissue by

electromagnetic fields, 6314 Electromotive force

Energetics of sodium transport in toad urinary bladder, 4591 Electron

see also Transport, electron; Transport, reverse electron Electron acceptor

internal charge transfer in proteins to Schiff bases of their lysine side chains, 3548

Electronic structure Fe-02 bonding and oxyheme structure in myoglobin, 2291

Electronic transition moment Bacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920 Electron injection

Electric double layer dynamics by high-field electroluminescence in aqueous solution (Destriau effect), 2549

Electron microscopy see also Immunoelectron microscopy Acetylcholine receptor localized in excitable membrane from electric

organ of Torpedo: Exposure of receptor antigenic sites on both sides of membrane, 2497

'y-Aminobutyric acid receptors: Ultrastructural localization in mammalian central nervous system by means of [3H]muscimol binding, 2977

Analysis of qOX DNA replication cycle by electron microscopy, 605 Artemia salina and Escherichia coli ribosome structure compared by

electron microscopy, 2829 ATP-induced conformational changes in restriction endonuclease from

Escherichia coli K-12, 3099 Bacteriorhodopsin: Molecular orientation within the purple membrane of

Halobacterium halobium, 4320 Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron

microscopic determination, 270 Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron

microscopic determination (correction), 2054 Cell surface of Micrococcus radiodurans: Topographic study, 5525 Combined immunofluorescence and high-voltage electron microscopy of


Complement lesion: Molecular nature, 5655



Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture cells by electron microscopy and by immunofluorescence microscopy, 1820

Diadenosine 5',5"'-P1,P4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells, 371

Differences in a and d polypeptide chains of tubulin resolved by electron microscopy with image reconstruction, 5006

Discrete length classes of DNA depend on mode of dehydration, 710 Electron microscopic heteroduplex analysis of "killer" double-stranded

RNA species from yeast, 4224 Endogenous New World primate type C viruses isolated from owl

monkey (Aotus trivirgatus) kidney cell line, 1004 Endoplasmic reticulum and autophagy in rat hepatocytes, 5039 Eukaryotic initiation factor 3 localized on native small ribosomal

subunits, 1389 Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312 Herpesvirus hexon capsomere: Direct evidence for 6-fold symmetry, 2764 Human mitochondrial DNA: Analysis of 7S DNA from origin of

replication, 735 Intercellular bridge from cultured mouse cells: Partial purification and

characterization, 4977 Intervening sequence of DNA identified in structural portion of a motuse

/-globin gene, 725 Intracellular development of bacteriophage X, with special reference to

DNA packaging, 3206 Kinetic factors and form determination of head of bacteriophage T4,

4165 Membrane particle aggregates in innervated and noninnervated cultures

'of Xenopus embryonic muscle cells, 500 Monovalent antibodies against MM-creatine kinase remove M line from

myofibrils, 4296 Motoneurons of the nematode Ascaris: Structure and physiological

activity, 3493 Myelin basic protein demonstrated immunocytochemically in

oligodendroglia prior to myelin sheath formation, 2521 Pituitary somatotrophs contain [Met]enkephalin-like immunoreactivity,

6134 Polyoma virus giant RNAs contain tandem repeats of nucleotide

sequence of entire viral genome, 4754 Replication in mitochondrial DNA molecules from Drosophila

melanogaster: Origin and direction, 3886 Role of nucleotides in tubulin polymerization: Effect of guanosine

5'-methylene diphosphonate, 3178 Site of adenylylation of glutamine synthetase localized by electron

microscopy of enzyme-antibody complex, 5778 Specific antibody and Clq binding to hapten-sensitized lipid vesicles

visualized, 3933 Structure of psoralen-crosslinked ribosomal RNA from Drosophila

melanogaster, 1642 Temperature-sensitive mutants of mouse hepatitis virus produce a high

incidence of demyelination, 4033 Ten-nanometer filaments of hamster BHK-21 cells and epidermal

keratin filaments have similar structures, 6098 Three-dimensional electron microscopical visualization of cytoskeleton of

animal cells: Immunoferritin identification of actin- and tubulin-containing structures, 5511


Vaccinia virus DNA: Visualization of an inverted terminal repetition, 4863


Zein messenger RNA: Purification and translation from maize endosperm protein bodies, 696

Electron nuclear double resonance Nitrogen electron nuclear double resonance and proton triple resonance

experiments on bacteriochlorophyll cation in solution, 2296 Electron paramagnetic resonance


Erythrocyte membrane abnormalities in Duchenne muscular dystrophy monitored by saturation transfer electron paramagnetic resonance spectroscopy, 838

Low molecular weight Ca2+ carrier isolated from calf heart inner mitochondrial membrane, 2125

Oxygen binding by hemoglobin, 5462 Sarcoplasmic reticulum Ca2+ATPase: Rotational motion, 5488

Electron probe Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329 Electron spin resonance

Cardiolipin: Stereospecifically spin-labeled analogtue and its specific enzymic hydrolysis, 1227


Electronic properties of some protein--methylglyoxal complexes, 315 Electron spin resonance studies on interaction of complement proteins

with erythrocyte membranes, 4930 Immobilized lipid in acetylcholine receptor-rich membranes from

Torpedo marmorata, 4329 Spin assay for reserve bilirubin loading capacity of human serum, 1542 Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127 Electron transfer

Bioluminescence of firefly: Key steps in formation of electronically excited state for model systems, 30




Complex III of mitochondrial electron transfer chain: Resolution into two component complexes, 5377

Cytochrome oxidase resolved into two component complexes, 5908 Nonexponential fluorescence decay of aqueous tryptophan and two

related peptides by picosecond spectroscopy, 4652 Electrophoresis

see also Immunoelectrophoresis Complex population of mRNA sequences in large polyadenylylated

nuclear RNA molecules, 5544 Coordinate control of corticotropin, /-lipotropin, and /1-endorphin

release in mouse pituitary cell cultures, 4972 Developmental change in human intestinal alkaline phosphatase, 3909 DNA unwinding induced by photoaddition of psoralen derivatives and

determination of dark-binding equilibrium constants by gel electrophoresis, 2703

Founder effect and number of private polymorphisms observed in Amerindian tribes, 1904


ml Moloney sarcoma virus pP60gag gene order: Unique peptides in carboxy terminus of the polyprotein, 4694

Murine complement component 3: Genetic variation and linkage to H-2, 963

Mutation rates in tribal Amerindians: Indirect estimates, 5585 RNA sequencing with radioactive chain-terminating ribonucleotides,


disguised by cofactor and subunit binding, 395 Tubulin from the yeast Saccharomyces cerevisiae identified, 4962

Electrophoresis, polyacrylamide gel Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and

uricase, 5066 Coated vesicles: Characterization, selective dissociation, and reassembly,

4394 Human mitochondrial DNA: Analysis of 7S DNA from origin of

replication, 735 Insulin binding to solubilized material from fat cell membranes:

Evidence for two binding species, 2593 Interferoids: In vitro and in vivo conversion of native interferons to

lower molecular weight forms, 4814 N gene protein of bacteriophage X identified, 2225 Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery in

heterocysts isolated from Anabaena variabilis, 6271 Oxygen-mediated heterogeneity of apo-low-density lipoprotein, 3173 Precursor molecules to individual tRNA species from Bombyx mori

identified, 635 Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260 Presence of two nonidentical subunits in NAD-dependent isocitrate

dehydrogenase of pig heart, 252 Units of transcription for cytoplasmic RNA in mouse myeloma cells,

4374 Electrophoresis, two-dimensional

Enrichment of special Novikoff hepatoma and regenerating liver mRNA by hybridization to cDNA-cellulose, 1736

G2 phase-specific proteins of HeLa cells, 6064 Influenza virus proteins: Identity, synthesis, and modification analyzed

by two-dimensional gel electrophoresis, 3625 Intercellular bridge from cultured mouse cells: Partial purification and

characterization, 4977 Low molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673 Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366 Proteins conferred by the virulence-specifying plasmid of Agrobacterium

tumefaciens C-58, 3796 Rate of macromolecular synthesis through cell cycle of Saccharomyces

cerevisiae, 4384 Ribosomal protein genes in Escherichia coli containing genes for

proteins S6, S18, and L9, 6163 RNase Tl-resistant oligonucleotides derived from genomes of Akv and

MCF murine leukemia viruses: Characterization and mapping, 495 Sequence of a RNA templated by 3'-OH RNA terminus of defective

interfering particles of vesicular stomatitis virus, 4704 Structural markers on core protein p30 of murine leukemia virus:

Functional correlation with Fv-1 tropism, 4170 Stuttering: High-level mistranslation in animal and bacterial cells, 1091

Electrophorus electricus Acetylcholine-receptor-mediated ion flux in electroplax membrane

microsacs (vesicles): Change in mechanism produced by asymmetrical distribution of sodium and potassium ions, 1703

Tetrodotoxin-binding component associated with voltage-sensitive sodium channel from Electrophorus electricus electroplax membranes: Purification, 2606

Electrophysiology In vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776 Electroretinogram

Generation of b-wave currents in skate retina, 5727 Elongation factor

Bacterial elongation factor Tu: Novel properties, 1250 Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104 Functional covalent complex between elongation factor Tu and an analog

of lysyl-tRNA, 3075 Guanosinetriphosphatase activity dependent on elongation factor Tu and

ribosomal protein L7/L12, 3192 Mutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470 Mutants of human diploid fibroblasts resistant to diphtheria toxin:

Isolation and characterization, 3337

Subject Index 6365


Pulvomycin, inhibitor of protein biosynthesis preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA, 5324

Two chromatographically separable forms of Escherichia coli elongation factor Tu, 1140

Embryogenesis Cell lineages of embryo of the nematode Caenorhabditis elegans, 376 Inhibition of putrescine synthesis blocks development of polychete

Ophryotrocha labronica at gastrulation, 1039 Stage-specific polypeptides synthesized during murine preimplantation

development: Identification, 3332 Translocation of DNA sequences during sea urchin embryogenesis, 5627

Embryo, mouse Metabolic cooperation between mouse embryonal carcinoma cells and

their differentiated derivatives, 3292 Mouse preimplantation embryos infected with simian virus 40 and

polyoma virus, 999 Emetic

Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P. marginellus (Coleoptera: Lampyridae), 905

Eminentia medialis Dense plexus of substance P immunoreactive nerve terminals in

eminentia medialis of primate hypothalamus, 1013 Encephalomyocarditis virus

3'-Terminal nucleotide sequence of encephalomyocarditis virus RNA determined by reverse transcriptase and chain-terminating inhibitors, 4257

Endocytosis Attack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825 Binding and internalization of epidermnal growth factor in human

carcinoma cells A-431: Visualization by fluorescence, 3317 Cholera toxin: Endocytosis into neuronal GERL, 2815 Direct visualization of binding, aggregation, and internalization of insulin

and epidermal growth factor on living fibroblastic cells, 2659 Endonuclease

see also Restriction endonuclease; Restriction enzyme; S1 endonuclease DNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA


Escherichia coli 16S ribosomal RNA: Processing of 5' end, 3598 Interferon action: Two distinct pathways for inhibition of protein

synthesis by double-stranded RNA, 5893 Mechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664 Phage T4 endonuclease V stimulates DNA repair replication in isolated

nuclei from ultraviolet-irradiated human cells, including xeroderma pigmentosum fibroblasts, 2598

Reconstitution of Escherichia coli repair endonuclease activity from separated uvrA+ and uvrB+.uvrC+ gene products, 2569

T4 RNA ligase used to construct model substrates for a ribosomal RNA maturation endonuclease, 3045

Endonuclease, apurinic Depurinated DNA repaired in vitro by enzymes purified from human

lymphoblasts, 794 Endoplasmic reticulum

Endoplasmic reticulum and autophagy in rat hepatocytes, 5039 Endoribonuclease

Ribonuclease P: An enzyme with an essential RNA component, 3717 Endorphin

Endorphins may function in heat adaptation, 2923 Endorphins may function in heat adaptation (correction), 4596

B6-Endorphin Coordinate control of corticotropin, /1-lipotropin, and /3-endorphin

release in mouse pituitary cell cultures, 4972 Corticotropin, lipotropin, and /-endorphin production by a human

nonpituitary tumor in culture: Evidence for common precursor, 5160 /-Endorphin: Biosynthesis from /-lipotropin and a larger molecular

weight precursor in rat pars intermedia, 4719 /-Endorphin induces inonconvulsive limbic seizures, 5221 /1-Endorphin-like immunoreactivity appears in human ventricular

cerebrospinal fluid upon analgesic electrical stimulation, 5170 /-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /-endorphin, 2950 /3-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /-endorphin (correction), 5244 /-Lipotropin, -y-lipotropin, and /-endorphin in rat pars intermedia: In

vitro biosynthesis and chemical characterization, 3153 Neurons containing /1-endorphin in rat brain exist separately from those

cointaining enkephalin: Immunocytochemical studies, 1591 Regional dissociation of /-endorphin and enkephalin contents in rat

brain and pituitary (correction), 1608 Systemic administration of ,/-endorphin: Potent hypotensive effect

involving a serotonergic pathway, 6240 Endosperm


Endotoxin Bone marrow colony-stimulating factor and tumor resistance-enhancing

activity of postendotoxin mouse sera, 2893 Lipid A and endotoxin in serum determined by mass spectroscopy, 3993 Pulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal

injection of bacterial lipopolysaccharide, 3998 Endplate current

Decamethonium both opens and blocks endplate channels, 2994



6366 Subject Index

Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents, 1596

Energy, activation RNA transport from isolated rat liver nuclei: Activation energy, 5400

Energy conformation Energy conformation study of Met-enkephalin and its D-Ala2 analogue

and their resemblance to rigid opiates, 7 Energy conformation study of Met-enkephalin and its D-Ala2 analogue

and their resemblance to rigid opiates (correction), 6337 Energy coupling

Cytochrome oxidase resolved into two component complexes, 5908 Energy restriction

Protein deficiency and energy restriction in young cebus monkeys, 1600 Energy transfer

Banding patterns in human metaphase chromosomes enhanced by energy transfer, 5650

Conformation of a membrane glycosyltransferase modulated by specific lipids, 3669

Fluorescence energy transfer in the rapid-diffusion limit, 5746 Intramolecular energy transfer in molecules with large number of

conformations, 1050 Topographical analysis of regulatory and metal ion binding sites on


Enkephalin Energy conformation study of Met-enkephalin and its D-Ala2 analogue

and their resemblance to rigid opiates, 7 Energy conformation study of Met-enkephalin and its D-Ala2 analogue

and their resemblance to rigid opiates (correction), 6337 High molecular weight opioid-containing proteins in striatum, 4021 [Met5lEnkephalin content in brain regions of rats treated with lithium,

2991 [5-Methionine]enkephalin and [5-leucinelenkephalin released in vitro

from rat globus pallidus, 3503 Neurons containing /-endorphin in rat brain exist separately from those

containing enkephalin: Immunocytochemical studies, 1591 Pituitary somatotrophs contain [Met]enkephalin-like immunoreactivity,

6134 Regional dissociation of /-endorphin and enkephalin contents in rat

brain and pituitary (correction), 1608 Enolase (EC 4.2.1.11)


Enterobactin Siderophore electrochemistry: Relation to intracellular iron release

mechanism, 3551 Enterotoxin


Enterotoxin-deficient mutants of Escherichia coli: Isolation and characterization, 1384

Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine, 2800

Enthalpy Proposed temperature-dependent conformational transition in D-amino

acid oxidase: Differential scanning microcalorimetric study, 2584 Entropy

Derivation of linear irreversible thermodynamics for classical fluids, 1632 Nonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 1627 Enucleation


Environmental variability Does environmental variability limit niche overlap? 5085

Enzyme see also Multienzyme complex; specific enzymes

Enzyme, allosteric Allosteric regulation of monocyclic interconvertible enzyme cascade

systems: Escherichia coli glutamine synthetase as an experimental model, 3138

Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and of its complex with cytidine triphosphate, 5276

Enzyme catalysis Enzyme catalysis: Energetics, 5250 Syncatalytic conformational changes in aspartate aminotransferase

determined by hydrogen-deuterium exchange, 145 Enzyme deficiency

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency, 472


Enzyme, immobilized Rationale for stabilization of oxygen-labile enzymes: Application to a

clostridial hydrogenase, 3640 Enzyme induction


Enzyme kinetics see also Kinetics Deacetylation of acetylchymotrypsin: Absence of evidence for an

intermediate, 172 Direct phosphorylation of brain tyrosine hydroxylase by cyclic

AMP-dependent protein kinase: Mechanism of enzyme activation, 4744


Enzyme-enzyme interactions: Unsymmetrical and concerted examples of effect on steady-state enzyme kinetics, 1101

Interacting enzyme systems at steady state: Location of phase transition in approximations of mean field type, 3015

Interacting enzyme systems at steady state: Further Monte Carlo calculations on two-state molecules, 5260

Mammalian protein kinase and phosphodiesterase activities inhibited by a cyclic AMP-like compound isolated from higher plants, 4301


Enzyme, lysosomal Thyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369 Enzyme precursor

Post-translational transport into intact chloroplasts of precursor to small subunit of ribulose-1,5-bisphosphate carboxylase, 6110

Enzyme purification Affinity purification of cardiac adenylate cyclase: Dependence on prior

hydrophobic resolution, 59 Enzyme regulation

3-Hydroxy-3-methylglutaryl coenzyme A reductase: Regulation of enzymatic activity by phosphorylation and dephosphorylation, 3678

Enzyme structure Yeast fatty acid synthetase subunits: Three-dimensional model of the

enzyme, 5792 Enzymoimmunoassay


Ephemerella dorothea Geometric model describing quasi-equilibrium of energy flow in

populations of stream insects, 381 Epidermal growth factor-urogastrone

Insulin and epidermal growth factor-urogastrone: Affinity crosslinking to specific binding sites in rat liver membranes, 1675

Epidermodysplasia verruciformis Two types of human papillomaviruses in lesions of epidermodysplasia

verruciformis, 1537 Epinephrine

Epinephrine-induced elevation of guanosine 3':5'-cyclic monophosphate in isolated fat cells of rat, 2684

Genetic regulation of galactokinase in Tetrahymena by cyclic AMP, glucose, and epinephrine, 1810


Epithelium Induction de novo of a gene product during heterologous

epithelial-mesenchymal interactions in vitro, 2790 Epoxide hydrase

see Epoxide hydratase Epoxide hydratase (EC 4.2.1.63)


Epstein-Barr virus Epstein-Barr virus and human chromosomes: Close association of


Herpesvirus-specific DNA polymerase isolated from tissues of an American patient with Burkitt lymphoma, 4504


Restricted classes of immunoglobulin produced by lymphoid cell line from patient with agammaglobulinemia, 2421


Translocation of hydrocarbon fluorescent probe between Epstein-Barr virus and lymphoid cells: Assay for early events in viral infection, 5076

Eptatretus stoutii Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679

Equation, Benjamin-Ono N-soliton solution of the Benjamin-Ono equation, 3562

Equation, boundary integral Connectivity as an alternative to boundary integral equations:

Construction of bases, 2059 Equation, Dirac

General relativity, the Dirac equation, and higher symmetries, 2568 Equation, Forster

Banding patterns in human metaphase chromosomes enhanced by energy transfer, 5650

Equation, logistic Social dynamics and quantifying of social forces, 4633

Equation, Nernst-Planck Ion flow through a membrane: Concentration and current responses to a

step potential change, 1612 Ion flow through a membrane: Effect of chemical reaction on time

dependence, 2064 Equation, nonlinear evolution

N-soliton solution of the Benjamin-Ono equation, 3562 Equation, nonlinear partial differential


Equation, partial difference Pompeiu's problem on discrete space, 3555

Equation, partial differential Connectivity as an alternative to boundary integral equations:

Construction of bases, 2059 High accuracy finite difference approximation to solutions of elliptic

partial differential equations, 2541




Local analytic hypoellipticity for Ob on nondegenerate Cauchy-Riemann manifolds, 3027

New class of pseudo-differential operators, 582 On positivity of pseudo-differential operators, 4673

Equation, wave Symmetry and causality properties of physical fields, 1609 Yang-Mills equations in physical space: General properties, 4638

Equation, Yang-Mills Yang-Mills equations in physical space: General properties, 4638

Ergocryptine Multiple receptors for brain dopamine, 1153

Ergocryptine, dihydro- o-Adrenergic receptors in caudate nucleus selectively labeled by


Presynaptic and postsynaptic a-adrenoceptors in rat heart membranes: Positive homotropic cooperativity of presynaptic binding, 6285

Ergot Serotonin receptors selectively labeled by d-[3H]lysergic acid

diethylamide in calf caudate, 5783 Erythrocyte

see also Membrane, erythrocyte ADP-ribosylation of membrane proteins catalyzed by cholera toxin:

Basis of activation of adenylate cyclase, 3050 Autosomal locus regulates inverse relationship between sialic acid




Erythrocytic mechanism of sickle cell resistance to malaria, 1994 Existence of only a single functional pool of adenosine triphosphate in

human erythrocytes, 2825 Founder effect and number of private polymorphisms observed in

Amerindian tribes, 1904 Glucose-6-phosphate dehydrogenase deficiency: Biochemical

mechanisms, 1979 Membrane sialic acid on target particles modulates their phagocytosis by

trypsin-sensitive mechanism on human monocytes, 3831 Membrane sialic acid regulates plH-dependent decay-dissociation of

amplification C3 convertase of alternative complement pathway, 1971 Plasma radioiron kinetics in man: Explanation for effect of plasma iron

concentration, 1559 Plasmodium knowvlesi-induced antigens in membranes of parasitized

rhesus monkey erythrocytes, 4949 Proteolytic activity in erythrocyte precursors, 3427 Separation of younger red cells with improved survival in vivo: Approach

to chronic transfusion therapy, 3474 Spectrin participates in Sendai virus-induced fusion of human

erythrocyte ghosts, 1740 Tracer exchange across C5b-9 complement lesion in a biological

membrane: Steady-state analysis, 5669 Two forms of bovine erythrocyte cytochrome b5 are identical to segments

of microsomal cytochrome b5, 3118 Erythroid tissue

Erythroid colony formation from human fetal liver, 984 Erythroleukemia


Erythropoiesis Changes in genome composition of Friend virus complex in



Erythropoietin Erythroid colony formation from human fetal liver, 984 Fetal hemoglobin synthesis in baboons stimulated by hemolysis and

hypoxia, 2937 Escherichia coli

Absolute configuration of diastereomers of adenosine 5'-O-(1-thiotriphosphate): Consequences for stereochemistry of polymerization by DNA-dependent RNA polymerase from Escherichia coli, 4798

Artemia salina and Escherichia coli ribosome structure compared by electron microscopy, 2829

ATP-induced conformational changes in restriction endonuclease from Escherichia coli K-12, 3099

Bioenergetics and glycolysis in anaerobic Escherichia coli cells: 31P nuclear magnetic resonance studies, 2244

Cell-cell interactions in conjugating Escherichia coli: Purification of F pili with biological activity, 1237

Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936 Computerized multidimensional scaling used to compare

immunoelectron microscopy data with protein near-neighbor information: Application to 30S ribosome from Escherichia coli, 3128

Coupling of lac mRNA transcription to translation in Escherichia coli cell extracts, 158


DNA sequence of araBAD promoter in Escherichia coli B/r, 4724 Escherichia coli plasmid bearing functional gene G of bacteriophage

4X174: Construction and characterization, 774 Escherichia coli recA gene product inactivates phage A repressor, 4714 Genetic recombination and complementation between bacteriophage T7

and cloned fragments of T7 DNA, 2276

Subject Index 6367

Glucose metabolism in Escherichia coli: High-resolution 13C nuclear magnetic resonance studies, 3742

Guanosine 5'-diphosphate 3'-diphosphate: Mechanism of in vitro breakdown in Escherichia coli, 4180


Identification of host protein necessary for bacteriophage morphogenesis (groE gene product), 131

In vitro system from Escherichia coli that catalyzes generalized genetic recombination, 3698

Nucleotide sequence of attenuator region of histidine operon of Escherichia coli K-12, 4276

Nucleotide sequence of leader region of phenylalanine operon of Escherichia coli, 4271

Nucleotide sequence of recognition site for restriction-modification enzyme of Escherichia coli B, 2266

06-Methylguanine: Repair in adapted Escherichia coli, 6017 Ornithine decarboxylase activity in Escherichia coli modulated by

positive and negative effectors, 4699 Oxidation of methionine residues of Escherichia coli ribosomal protein

L12 decreases the protein's biological activity, 5349 Plasmid-encoded protein required for replication in vitro of plasmid

R6K, 5381 Precursors of three exported proteins in Escherichia coli, 1209 Protein methylesterase involved in bacterial sensing, 3659 Pyruvate dehydrogenase multienzyme complex from Escherichia coli:

Mechanism of action, 4877. Rapid intramolecular coupling of active sites in pyruvate dehydrogenase

complex of Escherichia coli: Mechanism for rate enhancement in a multimeric structure, 5386

Recognition site of Escherichia coli B restriction enzyme on oXsBl and simian virus 40 DNAs: Interrupted sequence, 2271

Reconstitution of Escherichia coli repair endonuclease activity from separated uvrA+ and uvrB+ uvrC+ gene products, 2569

Role of the host in virus assembly: Cloning of Escherichia coli groE gene and identification of its protein product, 136

Specific binding of tRNAfMet to 23S rRNA of Escherichia coli, 1071 Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276 Topographical analysis of regulatory and metal ion binding sites on

glutamine synthetase from Escherichia coli: 13C and 31P nuclear magnetic resonance and fluorescence energy transfer study, '1255

Two chromatographically separable forms of Escherichia coli elongation factor Tu, 1140

Escherichia coli, genetics Complete nucleotide sequence of a 16S ribosomal RNA gene from

Escherichia coli, 4801 Contacts between Escherichia coli RNA polymerase and a lac operon

promoter, 5314 Cotranscription of genes for RNA polymerase subunits /f and /' with

genes for ribosomal proteins in Escherichia coli, 3891 Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104 Genetic recombination in Escherichia coli treated with psoralen and

light: Topography and kinetics, 2373 Homology-dependent cutting in trans of DNA in extracts of Escherichia

coli: Approach to enzymology of genetic recombination, 620 Physical organization of ilvEDAC genes of Escherichia coli strain K-12,

89 Transcription termination: Nucleotide sequence at 3' end of tryptophan

operon in Escherichia coli, 5442 Escherichia coli membrane



Escherichia coli membranes: Fluorine-19 nuclear magnetic resonance studies, 630

Functional lac carrier protein in cytoplasmic membrane vesicles isolated from Escherichia coli: Temperature and pH dependence of dansyl-galactoside binding, 4214

Homologous nucleotide sequences between prokaryotic and eukaryotic mRNAs: 5'-End sequence of mRNA of lipoprotein of Escherichia coli outer membrane, 2190


Matrix protein from Escherichia coli membranes forms voltage-controlled channels in lipid bilayers, 3751

Membrane vesicles from Escherichia coli: Molecular structure, 3148 Mutations altering cellular localization of phage X receptor, an

Escherichia coli outer membrane protein, 5802 Nascent peptide as sole attachment of polysomes to membranes in

bacteria, 814 Protein Ia and lamB protein can replace each other in constitution of an

active receptor for the same coliphage, 5636 Reduction of membrane potential, an immediate effect of colicin K, 2483 Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127 Structural proteins of an ATP-driven potassium transport system in

Escherichia coli, 3216 Escherichia coli mutant

Cellular division in Escherichia coli: Series of mutants of E. coli altered in penicillin-binding proteins, 664


Enterotoxin-deficient mutants of Escherichia coli: Isolation and characterization, 1384



6368 Subject Index

Escherichia coli dnaB mutant defective in DNA initiation: Isolation and properties of dnaB protein, 799

Escherichia coli mutant isolated lacking penicillin-sensitive D-alanine carboxypeptidase IA, 2631

Escherichia coli mutants defective in dipeptidyl carboxypeptidase, 5998 Escherichia coli mutant with amino acid alteration within signal

sequence of outer membrane prolipoprotein, 4891 /-Galactosidase chimeras: Primary structure of a lac

repressor-k/-galactosidase protein, 4824 /-Galactosidase from mutant strain 13 PO of Escherichia coli:

Functional properties, 1892 Mutant RNA polymerase of Escherichia coli terminates transcription in

strains making defective rho factor, 294 Mutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470 Mutation affecting thermostability of sigma subunit of Escherichia coli

RNA polymerase lies near dnaG locus at about 66 min on E. coli genetic map, 427

Phage Mu-1 integration: Nalidixic acid treatment causes clustering of Mu-l-induced mutations near replication origin, 4940

Ribosomal protein genes in Escherichia coli containing genes for proteins S6, S18, and L9, 6163

RNA polymerase and rho in interact transcription termination: Coupled ATPase, 4828

Single base-pair alteration in Escherichia coli trp operon leader region that relieve transcription termination at trp attenuator, 4833

Temperature-sensitive Escherichia coli mutant producing a temperature-sensitive a subunit of DNA-dependent RNA polymerase, 6177

Translational control of transcription termination at attenuator of Escherichia coli tryptophan operon, 5988

Transport of long-chain fatty acids by Escherichia coli: Mapping and characterization of mutants in fadL gene, 3377

Uracil incorporation: Source of pulse-labeled DNA fragments in replication of Escherichia coli chromnosome, 233

Ester cleavage Silane/iodine-based cleavage of esters and ethers under neutral

conditions, 4 Estradiol

Estrogen receptor binding and transcriptional activity: Role in stimulation of hyperestrogenism and nuclear bodies, 2781

Selective complexing of "nuclear" 5S estradiol receptor by serum component, 5S-CA, 2664

Soluble biospecific macromolecule for purification of estrogen receptor, 3143

Estradiol-17#f Estrogen control of prolactin synthesis in vitro, 5946 Opposing effects of estradiol and progesterone on oxytocin receptors in

rabbit uterus, 2044 Primary inductioin of vitellogenin mRNA in rooster by 17/-estradiol,

1815 Estrogen

see also Receptor, estrogen; specific estrogens Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effects

on liver surface membrane lipid structure and fuinction, 4130 Estrogen control of prolactin synthesis in vitro, 5946 Estrogen induction of growth factors specific for hormone-responsive

mammary, pituitary, and kidney tumor cells, 3786 Functional albumin mRNA decreased during estrogen-induced

vitellogenin biosynthesis in avian liver, 5974 Estrous cycle

Melatonin secretion decreases during proestrous stage of rat estrous cycle, 531

Ether cleavage Silane/iodine-based cleavage of esters and ethers under neutral

conditions, 4 Ethidium bromide

DNA unwinding induced by photoaddition of psoralen derivatives and determination of dark-binding equilibrium constants by gel electrophoresis, 2703

Euglena gracilis RNA metabolism, manganese, and RNA polymerases of zinc-sufficient

and zinc-deficient Euglena gracilis, 4175 Euphorbia characias


Evolution ADHs electromorph of Drosophila melanogaster: Structural analysis,

5609 Altruism: Its characteristics and evolution, 385 Amino acid sequence of / chain of human fibrinogen: Homology with y

chain, 1731 Cloned mouse (- and /3-globin genes: Conservation of intervening

sequence locations and extragenic homology, 6187 Complete amino-acid sequence of a2 heavy chain of human IgA2

immunoglobulin of A2m(2) allotype, 966 Evolutionary adaptation of membranes to temperature, 2040 Evolution of the nervous system: Role of ontogenetic mechanisms in

evolution of matching populations, 1349 Evolution of Y chromosomes and dosage compensation, 5618 Gene duplication in tetraploid fish: Model for gene silencing at unlinked

duplicated loci, 5575 Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679 Incomplete dosage compensation in evolving Drosophila sex

chromosome, 931 Kinetic factors and form determination of head of bacteriophage T4,

4165


Method to assess similarity of protein structures, with applications to T4 bacteriophage lysozyme, 2180

Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263 Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation and

characterization, 3268 Model of kin selection for an altruistic trait considered as a quantitative

character, 420 Origin of genetic code: Testable hypothesis based on tRNA structure,

sequence, and kinetic proofreading, 4334 Evolution, molecular

Conservation of ribosomal protein binding sites in prokaryotic 16S RNAs, 2859

Sequence variability of immunoglobulins considered from standpoint of population genetics, 5108

Evolution of proteins Protein tertiary structure: Formation on a computer, 554 Pseudomonas cytochrome c551 at 2.0 A resolution: Enlargement of

cytochrome c family, 2674 Evolution, social

Social dynamics and quantifying of social forces, 4633 Excitation

Molecular mechanism of excitation in visual transduction and bacteriorhodopsin, 549

Exocytosis Role of anions in parathyroid hormone release from dispersed bovine

parathyroid cells, 876 Exoenzyme S


Exonuclease VII Excision of DNA segments introduced into cloning vectors by

poly(dA.dT) joining method, 1763 Extinction

Group selection on a quantitative character, 3531 Mathematical theory of group selection: Structure of group selection in

founder populations determined from coInvexity of extinction operator, 1909

Eye see also Cornea; Lens; Retina Electrophysiological analysis of reinnervation of transplants in anterior

chamber of eye by autonomic ground plexus of iris, 1009

Factor VII Factor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539 Factor VIII

Venom coagglutinin: Activator of platelet aggregation dependent on von Willebrand factor, 4514

Factor XI Role of surface in surface-dependent activation of Hageman factor

(blood coagulation Factor XII), 1998 Factor XII

Role of surface in surface-dependent activation of Hagemarn factor (blood coagulation Factor XII), 1998

Factor XIII Ca2+-related regulatory function of fibrinogen, 4234

Factor IX Factor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539 Familial amyloidotic polyneuropathy

Amyloid fibril protein related to prealbumnin in familial amyloidotic polyneuropathy, 4499

Familial hypercholesterolemia Receptor-mediated uptake of low density lipoprotein reconsitituted with


Fatigue Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329 Fatty acid




Fatty acid synthetase Interaction of mycobacterial polymethylpolysaccharides with paranaric

acid and palmitoyl-coenzyme A: Structural specificity and monomeric dissociation constants, 691

Rat liver fatty acid synthetase mRNA translated in a cell-free system derived from wheat germ, 730


Ferredoxin Cluster characterization in iron-sulfur proteins by magnetic circular

dichroism, 5273 Ferredoxin hydrogenase (EC 1.12.7.1)


Ferroxidase (EC 1.16.3.1) Coordination environment and fluoride binding of type 2 copper in the

blue copper oxidase ceruloplasmin, 4078 Fertility

Fertility repression of F-like conjugative plasmids: Physical mapping of R6-5 finO and finP cistrons and identification of finO protein, 5836




Temperature-sensitive mutants in Tetrahymena: Mass isolation and fertility testing, 3355

Fertilization Egg surface glycoprotein receptor for sea urchin sperm bindin, 881 Hydrogen peroxide production, chemiluminescence, and respiratory



a-Fetoprotein Adult murine T cells activated in vitro by (v-fetoprotein and naturally

occurring T cells in newborn mice: Identity in function and cell surface differentiation antigens, 2897

Growth state-dependent phenotypes of adult hepatocytes in primary monolayer culture, 1834

Fibrin Synthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers, 3085 Synthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers (correction), 5742 Fibrinogen

Amino acid sequence of /f chain of human fibrinogen: Homology with y' chain, 1731

Ca2+-related regulatory function of fibrinogen, 4234 Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506 Synthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers, 3085 Synthetic peptide derivatives that bind to fibrinogen and prevent

polymerization of fibrin monomers (correction), 5742 Fibrinolysin

see Plasmin Fibrinolysis

Nerve growth factor: A protease that can activate plasminogen, 5497 Fibroblast

Attachment and spreading of baby hamster kidney cells to collagen substrata: Effects of cold-insoluble globulin, 4408


Chemotactic attraction of human fibroblasts to type I, II, and III collageins and collagen-derived peptides, 871

Cholesteryl ester formation in human fibroblasts inhibited by analogue of 7-ketocholesterol and by progesterone, 1877

Codistribution of pericellular matrix proteins in cultured fibroblasts alnd loss in transformation: Fibronectin and procollagen, 4944

Conjugation of poly-L-lysine to albumin and horseradish peroxidase: Method of enhancing cellular uptake of proteins, 1872

Corticosteroids: Action in regulation of prostaglandin biosynthesis in cultured fibroblasts, 214


Detection of early surface change during oncogenic transformation, 3703 Direct visualization of binding, aggregation, and internalization of insulin

and epidermal growth factor on living fibroblastic cells, 2659 Does 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in

oocytes of Xenopus laevis? 5030 Epidermal growth factor: Morphological demonstration of binding,

internalization, and lysosomal association in human fibroblasts, 5025 Glucose binding and transport proteins extracted from fast-growing

chicken fibroblasts, 5427 Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,

hydrocortisone, and dibutyryl cyclic AMP, 1418 Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057 Lack of correlation between tumorigenicity and level of plasminogen

activator in fibroblasts transformed by Rous sarcoma virus, 4967 Lateral diffusion coefficients of hormone--receptor complexes of insulin


Mid-G1 marker protein(s) in 3T3 mouse fibroblast cells, 4959 Mutants of human diploid fibroblasts resistant to diphtheria toxin:

Isolation and characterization, 3337 Neoplastic transformation of human cliploid fibroblast cells by chemical

carcinogens, 1334 Ouabain-resistant mutations induced in C3H IOTI/2 mouse cells by

ultraviolet light, 3363 Proteases induce secretioin of collagenase and plasminogen activator by

fibroblasts, 1839 Purine metabolism in cultured human fibroblasts from patients deficient

in hypoxanthine phosphoribosyltransferase, purine nucleoside phosphorylase, or adenosine deaminase, 3722



Rous sarcoma virus replication and cell transformation inhibited by a specific oligodeoxynucleotide, 280

Sanfilippo syndrome type C: Deficiency of acetyl-CoA:o-glucosaminide N-acetyltransferase in skin fibroblasts, 5185

Serum stimulates Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry, 5560



Subject Index 6369

Steroid hormones mediate reversible phenotypic transition between transformed and untransformed states in mouse fibroblasts, 2805

Transformation-dependent secretion of low molecular weight protein by murine fibroblasts, 2767

Tumor cell surface antigen from spontaneously transformed BALB/c mouse fibroblasts: Isolation and characterization, 5912


Fibronectin Attachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408 Codistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944 Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621 Fibronectin: Identification, localization, and role in cultured bovine

endothelial cells, 3273 Fibronectin is the collagen receptor onm platelet membranes, 5864 Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548 Genetics of large, external, transformation-sensitive (LETS) protein:

Assignment of gene coding for expression of LETS to human chromosome 8, 5640

High molecular weight cell surface glycoprotein (LETS protein) expressed by preimplantation mouse embryos and teratocarcinoma stem cells, 2324

Filament see also Microfilament; Neurofilament Bacterial elongation factor Tu: Novel properties, 1250 Differences among 100-A filament subunits from different cell types,

4364 Different intermediate-sized filaments distinguished by

immunof'luorescence microscopy, 5034 Ten-nanometer filaments of hamster BHK-21 cells and epidermal

keratin filaments have similar structures, 6098 Filter paper


Firefly see also Photinus ignitus; Photinus marginellus Bioluminescence of firefly: Key steps in formation of electronically

excited state for model systems, 30 Fish

Gene duplication in tetraploid fish: Model for gene silencing at unlinked duplicated loci, 5575

Fisher's "reproductive value" Generalizing Fisher's "reproductive value": Overlapping and

nonoverlapping generations with competing genotypes, 4062 Generalizing Fisher's "reproductive value": "Incipient" and

"penultimate" reproductive-value functions when environment limits growth; linear approximants for nonlinear Mendelian mating models, 6327

Fitness potential Phenotypic selection: Effect on genetic change at individual loci, 6168

Flagella Inversion of a behavioral response in bacterial chemotaxis: Explanation

at molecular level, 4150 Flavoprotein

Oxygen adduct intermediate in bacterial luciferase reaction: 13C nuclear magnetic resonance determination of structure, 5860

Pyruvate dehydrogenase multienzyme complex from Escherichia coli: Mechanism of action, 4877

Flow cytometry RNA content in human lymphocyte subpopulations, 1938

Flow microfluorometry Lengthening of G1 phase is not strictly correlated with differentiation in

Friend erythroleukemia cells, 3813 Simian virus 40 A gene function: DNA content analysis of Chinese


Fluid I)erivation of linear irreversible thermodynamics for classical fluids, 1632

Fluorescamine I)etection of early surface change during oncogenic transformation, 3703

Fluorescein, 5-iodoacetamido- Molecular cytochemistry: Incorporation of fluorescemntly labeled actin

into living cells, 857 Fluorescence

see also Immunofluorescence Banding patterns in human metaphase chromosomes enhanced by

energy transfer, 5650 Binding and internalization of epidermal growth factor in human

carcinoma cells A-431: Visualization by fluorescence, 3317 Bioluminescence of firefly: Key steps in formation of electronically

excited state for model systems, 30 Coherent stimulated light emission (lasing) in covalently linked

chlorophyll dimers, 2076 Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669 Decreased microviscosity of membrane lipids in leukemic cells: Two

possible mechanisms, 2306 Detection of early surface change during oncogenic transformation, 3703 Direct fluorescent assay of urokinase and plasminogen activators of

normal and malignant cells: Kinetics and inhibitor profiles, 750 Direct visualization of binding, aggregation, and internalization of insulin

and epidermal growth factor on living fibroblastic cells, 2659 Distinct protein components from Torpedo marmorata membranes carry


Fluorescence energy transfer in the rapid-diffusion limit, 5746



6370 Subject Index

Fluorescence probe measurement of intralysosomal pH in living cells and perturbation of pH by various agents, 3327

Fluorescent labeling of hormone receptors in viable cells: Preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin, 2135

Four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism, 5466



Intramolecular energy transfer in molecules with large number of conformations, 1050

Lateral diffusion coefficients of hormone-receptor complexes of insulin and epidermal growth factor on plasma membrane of cultured fibroblasts: Quantitative determination, 5353

Ligands containing heavy atoms: Perturbation of phosphorescence of a tryptophan residue in binding site of wheat germ agglutinin, 1324




Molecular motion in membranes determined using periodic pattern photobleaching, 2759

Nonexponential fluorescence decay of aqueous tryptophan and two related peptides by picosecond spectroscopy, 4652

Physicochemical characterization of six monoclonal cryoimmunoglobulins: Basis for cold-dependent insolubility, 3440



Susceptibility to mitogens retained after direct dansylation of viable human lymphocytes, 3766

Topographical analysis of regulatory and metal ion binding sites on glutamine synthetase from Escherichia coli: 13C and 31P nuclear magnetic resonance and fluorescence energy transfer study, 1255

Fluorescence depolarization Membrane-bound neuraminidase from calf brain: Regulation of



Fluorescence polarization Translocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076 Fluorescent light

Fluorescent light-induced chromosome damage and its prevention in mouse cells in culture, 1830

Fluorescent photoaffinity labeling Fluorescent photoaffinity labeling: Adenosine 3':5'-cyclic monophosphate

receptor sites, 1199 Fluoride


Interaction of fluoride- and guanylyl-5'-imidodiphosphate-regulatory proteins with adenylate cyclase, 3693

Fluorimetry Proposed temperature-dependent conformational transition in D-amino

acid oxidase: Differential scanning mnicrocalorimetric study, 2584 Fluorine-19


Folate Cytotoxicity of 5-fluoro-2'-deoxyuridine: Requirement for reduced folate

cofactors and antagonism by methotrexate, 980 High-affinity folate binding activity associated with brush border

membranes of rat kidney, 3090 Interaction of methotrexate, folates, and pyridine nucleotides with


Follicle-stimulating hormone see Follitropin

Follitropin Rat oocyte maturation in vitro: Relief of cyclic AMP inhibition by

gonadotropins, 4369 Fossil

Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263 Founder effect

Founder effect and number of private polymorphisms observed in Amerindian tribes, 1904

Mathematical theory of group selection: Structure of group selection in founder populations determined from convexity of extinction operator, 1909

Probability of founder effect in a tribal population, 1442 Fourier series

Localization for double Fourier series, 580 Fourier-Stieltjes series

Some new singular Fourier-Stieltjes series, 5268


Fourier transform Differentiation in lacunary directions, 1060 Kinetics of desynchronization and distribution of generation times in

synchronized cell populations, 4404 F pilus


Freeze-fracture Clusters of intramembranous particles on cultured myotubes at sites that

are highly sensitive to acetylcholine, 3004 French bean

see Phaseolus vulgaris Friend virus

see Leukemia virus, Friend Frog

see Rana catesbeiana; Rana esculenta Fructose-bisphosphatase (EC 3.1.3.11)

Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase with Zn2+ as cofactor, 2185

Fucose Biosynthesis in vitro of fucose-containing glycosphingolipids in human

neuroblastoma IMR-32 cells, 289 Carbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315 Hepatic receptor that specifically binds oligosaccharides containing

fucosyl (Yl-3 N-acetylglucosamine linkages, 2215 a-Fucosyltransferase (EC 2.4.1.89)

Biosynthesis in vitro of fucose-containing glycosphingolipids in human neuroblastoma IMR-32 cells, 289

Function, L Automorphic L-functions of half-integral weight, 1620

Galactokinase (EC 2.7.1.6) Chimeric mice derived from human-mouse hybrid cells, 1914 Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,

glucose, and epinephrine, 1810 Thymidine kinase and galactokinase genes: Cotransfer by

chromosome-mediated gene transfer, 914 Galactoprotein a


Galactose Myoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568 Regulation of galactose pathway in Saccharomyces cerevisiae: Induction

of uridyl transferase mRNA and dependency on GAL4 gene function, 2878

Galactose-l-phosphate uridyltransferase (EC 2.7.7.10) Regulation of galactose pathway in Saccharomyces cerevisiae: Induction


/3-Galactosidase /-Galactosidase chimeras: Primary structure of a lac

repressor-/-galactosidase protein, 4824 Immunological screening method to detect specific translation products,

2746 ,/-Galactosidase (EC 3.2.1.23)

Antibody-mediated activation of defective /1-D-galactosidase: Dimeric form of activatable mutant enzyme, 720

Evolution of /1-galactosidase, 113 /1-Galactosidase from mutant strain 13 PO of Escherichia coli:

Functional properties, 1892 /-Galactosidase is induced by hormone in Drosophila melanogaster cell

cultures, 6102 Galactoside, dansyl-

Functional lac carrier protein in cytoplasmic membrane vesicles isolated from Escherichia coli: Temperature and pH dependence of dansyl-galactoside binding, 4214

Galactosyltransferase Growth of transformed cells and tumors inhibited by endogenous

acceptor of galactosyltransferase, 4426 a-Galactosyltransferase (EC 2.4.1.87)

Biosynthesis in vitro of fucose-containing glycosphingolipids in human neuroblastoma IMR-32 cells, 289

,/-Galactosyltransferase (EC 2.4.1.86) Biosynthesis in vitro of fucose-containing glycosphingolipids in human

neuroblastoma IMR-32 cells, 289 Galaxy

Ionized gas in Seyfert and radio-galaxy nuclei: Observational model, 540 Gallstone

Cholesterol monohydrate growth in model bile solutions, 6230 Gamma heavy chain disease

Gamma heavy chain disease in man: Translation and partial purification of mRNA coding for deleted protein, 4774

Ganglion Adrenergic differentiation of cells of cholinergic ciliary and Remak

ganglia in avian embryo after in uivo transplantation, 2030 oo-Bungarotoxin blocks nicotinic transmission in avian ciliary ganglion,

2999 Interneuron involved in generation of slow inhibitory postsynaptic

potential in mammalian sympathetic ganglia, 4029 Subcellular fractionation of intra-axonally transported polypeptides in

rabbit visual system, 505 Ganglioside

AB variant of infantile GM2 gangliosidosis: Deficiency of factor necessary for stimulation of hexosaminidase A-catalyzed degradation of ganglioside GM2 and glycolipid GA2, 3979




Affinity filters, approach to isolation of tox mutants of Vibrio cholerae, 941





Thyroid phospholipids: Effect on interaction of thyrotropin with thyroid membranes, 5301

Gangliosidosis AB variant of infantile GM2 gangliosidosis: Deficiency of factor necessary


Gap junction Electrotonic synapses uncoupled by calcium, 4577 Metabolic cooperation between mouse embryonal carcinoma cells and

their differentiated derivatives, 3292 Garding inequality

On positivity of pseudo-differential operators, 4673 Gas

Ionized gas in Seyfert and radio-galaxy nuclei: Observational model, 540 One-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084 Gastrin


Gastrointestinal factor Influence of hyperinsulinemia, hyperglycemia, and the route of glucose

administration on splanchnic glucose exchange, 5173 Gastrointestinal hormone

Cholecystokinin-like immunoreactivity localized in isolated nerve terminals, 6324

Gastrointestinal hormones Polypeptide hormones: Chemical determination, 4115

Gating process Asymmetric displacement currents in giant axons and macromolecular

gating processes, 4911 Gaucher disease

Gaucher disease: Isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue, 3970

Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher disease, 2448

Gene see also Operon Genetic variation at a highly polymorphic esterase locus in Drosophila

pseudoobscura, 5090 Mtv-2 gene responsible for early appearance of mammary tumors in GR

mouse by nucleic acid hybridization, 2368 Murine complement component 3: Genetic variation and linkage to H-2,

963 Transfection of Fv-1 permissive and restrictive mouse cells with

integrated DNA of murine leukemia viruses, 1451 Gene, A

Purified simian virus 40 T antigen proteins: Biological activity, 1279 Simian virus 40 A gene function: DNA content analysis of Chinese


Gene, ampicillin resistance Nucleotide sequence of ampicillin resistance gene of Escherichia coli

plasmid pBR322, 3737 Gene amplification


Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312 Gene, amylase


Gene, cheU Inversion of a behavioral response in bacterial chemotaxis: Explanation

at molecular level, 4150 Gene, CYC7

Chromosome mapping of CYC7 gene determining yeast iso-2-cytochrome c: Structural and regulatory regions, 1437

Gene, dnaG Mutation affecting thermostability of sigma subunit of Escherichia coli


Gene-dosage compensation Evolution of Y chromosomes and dosage compensation, 5618

Gene-dosage effect Influence of homoeologous chromosomes on gene-dosage effects in

allohexaploid wheat (Triticum aestivum L.), 1446 Gene duplication

Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104 Gene duplication in tetraploid fish: Model for gene silencing at unlinked

duplicated loci, 5575 Gene, env

Large Tl oligonucleotides of Moloney leukemia virus missing in env gene recombinant HIX, are present on intracellular 2 S Moloney viral RNA species, 2964

Large T1 oligonucleotides of Moloney leukemia virus missing in env gene recombinant, HIX, are present on intracellular 21S Moloney viral RNA species (correction), 5244

Subject Index 6371

Gene, esterase-5 Genetic variation at a highly polymorphic esterase locus in Drosophila

pseudoobscura, 5090 Gene expression

Abnormal cellular localization of thyroglobulin mRNA associated with hereditary congenital goiter and thyroglobulin deficiency, 74


Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936 Ecdysone-inducible functions of larval fat bodies in Drosophila, 5570 Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896 Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)

controlled by a bacterial insertion element (IS2), 6172 Expression of simian virus 40 early genes in transformed rat cells is

correlated with maintenance of transformed phenotype, 4987. Influence of homoeologous chromosomes on gene-dosage effects in

allohexaploid wheat (Triticum aestivum L.), 1446 Mechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664 Physical organization of ilvEDAC genes of Escherichia coli strain K-12,

89 Post-transcriptional suppression of globin gene expression in cells

tranisformed by avian erythroblastosis virus, 3776 Translation of animal virus RNA in cytoplasm of plant cell, 5557 Viral sequences of low reiteration frequency detected by in situ

hybridization, 6125 Gene, fadL


Gene, fertility inhibition Fertility repression of F-like conjugative plasmids: Physical mapping of

R6-5 finO and finP cistrons and identification of finO protein, 5836 Gene frequency

see also Allele frequency Change of gene frequencies by natural selection under population

number regulation, 1934 Phenotypic selection: Effect on genetic change at individual loci, 6168

Gene, Fv-1 Transfection of Fv-1 permissive and restrictive mouse cells with

integrated DNA of murine leukemia viruses, 1451 Gene, G

Escherichia coli plasmid bearing functional gene G of bacteriophage OX174: Construction and characterization, 774

Gene, gag Amino- and carboxyl-terminal amino acid sequences of proteins coded

by gag gene of murine leukemia virus, 1404 ml Moloney sarcoma virus pP60gag gene order: Unique peptides in

carboxy terminus of the polyprotein, 4694 Serological characterization of B-tropic viruses of C57BL mice: Possible

origin by recombination of endogenous N-tropic and xenotropic viruses, 4553

Gene, GAL Regulation of galactose pathway in Saccharomyces cerevisiae: Induction


Gene, globin Changes in restricted human cellular DNA fragments containing globin

gene sequences in thalassemias and related disorders, 1222 Chromosomal localization of human ft globin gene on human

chromosome 11 in somatic cell hybrids, 1456 Cloned mouse (- and /1-globin genes: Conservation of intervening

sequence locations and extragenic homology, 6187 Duplicated human ( globin genes lie close together in cellular DNA, 5950 Hemoglobin switching in sheep: Only the -y gene is in active

conformation in fetal liver but all the / and -y genes are in active conformation in bone marrow, 5884

Intervening sequence of a mouse /1-globin gene is transcribed within 15S /3-globin mRNA precursor, 1309

Intervening sequence of DNA identified in structural portioln of a mouse /1-globin gene, 725

Polymorphism of DNA sequence adjacent to human /-globin structural gene: Relationship to sickle mutation, 5631

Post-transcriptional suppression of globin gene expression in cells transformed by avian erythroblastosis virus, 3776

Gene, groE Identification of host protein necessary for bacteriophage morphogenesis

(groE gene product), 131 Role of the host in virus assembly: Cloning of Escherichia coli groE gene

and identification of its protein product, 136 Gene, hisP

Membrane protein identified as a histidine transport component in Salmonella typhimurium, 5447

Gene, histocompatibility H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur

in chimeric mice, 6207 Two HLA-linked loci controlling the fourth component of human

complement, 5165 Gene, histone

Hatching in sea urchin Lytechinus pictus is accompanied by shift in histone H4 gene activity, 4135

Gene, ilvEDAC Physical organization of ilvEDAC genes of Escherichia coli strain K-12

89 Gene, immunoglobulin

Chromosomal locations of mouse immunoglhobulin genes, 2883 DNA clones containing mouse immunogloobulin K chain genes isolated by

in vitro packaging into phage A coats, 4709 (Genes for immunoglobulin K and heavy chains assigned to chromosomes

6 and 12 in mouse, 4494



6372 Subject Index

Myeloma variants with predefined variant surface immunoglobulin isolated by cell sorting, 3901

Variable region genes for immunoglobulin framework are assembled from small segments of DNA: A hypothesis, 2429

Gene, immunoglobulin heavy chain Organization of immunoglobulin heavy chain genes and allelic deletion

model, 2140 Gene, immunoglobulin variable region


Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis, 3881

Gene inactivation Transposition of plasmid DNA segments specifying hydrocarbon

degradation and their expression in various microorganisms, 3109 Gene, insulin

Genes for human insulin: Chemical synthesis, 5765 Major polyadenylylated transcription products and the genes active in

their synthesis in a rat insulinoma identified, 3249 Gene, Ir


Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly(Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion, 2387


Gene, LETS Genetics of large, external, transformation-sensitive (LETS) protein:

Assignmrent of gene coding for expression of LETS to humnan chromosome 8, 5640

Gene linkage Duplicated human ca globin genes lie close together in cellular DNA, 5950

Gene, mitochondrial Teratocarcinoma cells as vehicles for introducing specific mutant

mitochondrial genes into mice, 5113 Gene, Mtv-2

Identification of Mtv-2 gene responsible for early appearance of mammary tumors in GR mouse by nucleic acid hybridization, 2368

Gene organization Intragenic DNA spacers interrupt the ovalbumin gene, 1299

Gene, ovalbumin Intragenic DNA spacers interrupt the ovalbumin gene, 1299 Ovalbumin gene: A leader sequence in mRNA and DNA sequences at

exon-intron boundaries, 4853 Ovalbumin gene: Cloning of natural gene, 3688 Ovalbumin gene: Structuiral sequences in native chicken DNA are not

contiguous, 2205 Preferential transcription of ovalbumin gene in isolated hen oviduct

nuclei by RNA polymerase B, 686 Gene, pro-a2 collagen

Recombinant bacterial plasmid constructed containing a chick pro-a2 collagen gene sequence, 5846

General covariance General relativity, the Dirac equation, and higher symmetries, 2568

General relativity General relativity, the Dirac equation, and higher symmetries, 2568 Incompressible minimal surfaces, three-dimensional manifolds with

nonnegative scalar curvature, and positive mass conjecture in general relativity, 2567

Gene rearrangement, somatic DNA clones containing mouse immunoglobulin K chain genes isolated by

in vitro packaging into phage X coats, 4709 Gene, recA

Escherichia coli recA gene product inactivates phage X repressor, 4714 Gene, recB

Early events and mechanisms in induction of bacterial SOS functions: Analysis of phage repressor inactivation process in vivo, 1657

Gene regulation Functional albumin mRNA decreased during estrogen-induced

vitellogenin biosynthesis in avian liver, 5974 Primary induction of vitellogenin mRNAin rooster by 173-estradiol,

1815 Gene repression

Age-dependent relaxation of gene repression: Increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice, 4431

Gene, rho RNA polymerase and rho in interact transcription termination: Coupled

ATPase, 4828 Gene, ribosomal

Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367 Gene, ribosomal protein

Cotranscription of genes for RNA polymerase subunits f and ft' with genes for ribosomal proteins in Escherichia coli, 3891


Gene, Rnr Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623 Gene, rrnB

Complete nucleotide sequence of a 16S ribosomal RNA gene from Escherichia coli, 4801

Gene, selection coefficient of Phenotypic selection: Effect on genetic change at individual loci, 6168

Gene, simian virus 40 Early genes of simian virus 40: Organization and expression, 117


Expression of simian virus 40 early genes in transformed rat cells is correlated with maintenance of transformed phenotype, 4987

Gene, small tumor antigen Nucleotide sequence of simian virus 40 small-t gene, 2160

Gene, src Assay for early cytoplasmic effects of src gene product of Rous sarcoma

virus, 2750 DNA synthesis induced in terminally differentiated myotubes by

activation of src gene of Rous sarcoma virus, 5501 Isolation of stable rat sarcoma viruses in vitro, 2972 Polypeptide encoded by avian sarcoma virus src gene: Identification,

1567 Processing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399 Protein kinase activity associated with avian sarcoma virus src gene

product, 2021 Recombination between viral and cellular sequences generates

transforming sarcoma virus, 5812 Reversion of transformed glycolysis to normal by inhibition of protein


Structural markers on core protein p30 of murine leukemia virus: Functional correlation with Fv-l tropism, 4170

Gene, steel Normal blood cells of anemic genotype in teratocarcinoma-derived

mosaic mice, 6247 Gene, suppressor transfer ribonucleic acid

Transduction of a bacterial gene into mammalian cells, 2117 Genetic code

Origin of genetic code: Testable hypothesis based on tRNA structure, sequence, and kinetic proofreading, 4334

Physical basis for ambiguity in genetic coding interactions, 610 Stuttering: High-level mistranslation in animal and bacterial cells, 1091 "Two out of three": Alternative method for codon reading, 1759

Genetic deficiency Diet, genetics, and mental retardation interaction between


Genetic dimorphism Genetic dimorphism in influenza viruses: Characterization of stably

associated hemagglutinin mutants differing in antigenicity and biological properties, 6258

Genetic diploidy Electrophoretic shift mutants in Chinese hamster ovary cells: Evidence

for genetic diploidy, 1919 Genetic drift

Gene duplication in tetraploid fish: Model for gene silencing at unlinked duplicated loci, 5575

Random genetic drift in a cline, 423 Genetic map

Assignment of genes to regions of moutse chromosomes, 946 BK virus DNA: Cleavage map and sequence analysis, 2150 Cellular division in Escherichia coli: Series of mutants of E. coli altered

in penicillin-binding proteins, 664 Chromosomal localization of human / globin gene on human

chromosome 11 in somatic cell hybrids, 1456 Co-transfer of human X-linked markers into murine somatic cells via





Genetic recombination between mouse type C RNA viruses: Mechanism for endogenous viral gene amplification in mammalian cells, 923

Homologous genes for enolase, phosphoglticonate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome lp, 2382

Maize plastid gene expressed during photoregulated development, 3060 Mutation affecting thermostability of sigma subunit of Escherichia coli


Physical organization of ilvEDAC genes of Escherichia coli strain K-12, 89

Polymorphism of DNA sequence adjacent to human f-globin structural gene: Relationship to sickle mutation, 5631

Spliced early mRNAs of simian virus 40, 1274 Thymidine kinase and galactokinase genes: Cotransfer by

chromosome-mediated gene transfer, 914 Transport of long-chain fatty acids by Escherichia coli: Mapping and

characterization of mutants in fadL gene, 3377 X-linkage of human phosphoribosylpyrophosphate synthetase, 482

Genetic mosaicism Chimeric mice derived from human-mnouse hybrid cells, 1914

Genetic recombination see Recombination, genetic

Genetic regulation Control of antibody heterogeneity in strain 2 guinea pigs, 959 DNA sequence from histidine operon control region: Seven histidine

codons in a row, 4281 DNA sequences amplified during chicken cartilage and neural retina

differentiation, 4451 Genetic regulation of tissue-specific expression of amylase structural

genes in Drosophila melanogaster, 4446 H-2.28, an alloantigenic marker allelic to H-2.1, is expressed on all three

known types of H-2 molecules, 4441





Nucleotide sequence of attenuator region of histidine operon of Escherichia coli K-12, 4276


Primary induction of vitellogenin mRNA in rooster by 17/-estradiol, 1815

Genetics see also Cytoplasmic inheritance

Genetics, biparental Generalizing Fisher's "reproductive value": Overlapping and

nonoverlapping generations with competing genotypes, 4062 Genetic selection

Generalizing Fisher's "reproductive value": "Incipient" and "penultimate" reproductive-value functions when environment limits growth; linear approximants for nonlinear Mendelian mating models, 6327

Genetics, population ADHS electromorph of Drosophila melanogaster: Structural analysis,

5609 Change of gene frequencies by natural selection under population

number regulation, 1934 Estimation of expected number of rare alleles of a locus and calculation

of mutation rate, 5094 Founder effect and number of private polymorphisms observed in

Amerindian tribes, 1904 Genetic variability: Theoretical study assuming stepwise production of

neutral and very slightly deleterious mutations, 919 Group selection on a quantitative character, 3531 Kin selection: A classical approach and a general solution, 6154 Mathematical theory of group selection: Structure of group selection in

founder populations determined from convexity of extinction operator, 1909

Mutation rates in tribal Amerindians: Indirect estimates, 5585 Probability of founder effect in a tribal population, 1442 Random genetic drift in a cline, 423 Sequence variability of immunoglobulins considered from standpoint of

population genetics, 5108 Stepwise mutation model and distribution of allelic frequencies in a

finite population, 2868 Genetics, quantitative

Model of kin selection for an altruistic trait considered as a quantitative character, 420

Genetics, somatic cell Co-transfer of human X-linked markers into murine somatic cells via

isolated metaphase chromosomes, 3346 Cytoplasmic inheritance of rutamycin resistance in mouse fibroblasts,

324 Entrapment of metaphase chromosomes into phospholipid vesicles



Genetic analysis of G1 period: Isolation of mutants (or variants) with a G1 period from Chinese hamster cell line lacking G1, 2873


Thymidine kinase and galactokinase genes: Cotransfer by chromosome-mediated gene transfer, 914

Genetic toxicology Quantitative forward mutation assay in Salmonella typhimurium using

8-azaguanine resistance as a genetic marker, 410 Relative sensitivities of forward and reverse mutation assays in

Salmonella typhimurium, 4465 Genetic transmission


Genetic variability ADHS electromorph of Drosophila melanogaster: Structural analysis,

5609 Biochemical evidence that "new" influenza virus strains in nature may

arise by recombination (reassortment), 3341 Genetic variability: Theoretical study assuming stepwise production of

neutral and very slightly deleterious mutations, 919 Genetic variation at a highly polymorphic esterase locus in Drosophila

pseudoobscura, 5090 Genetic variant

Probability of founder effect in a tribal population, 1442 Gene transfer

"Conjugal" transfer of plasmid DNA among oral streptococci, 3484 Co-transfer of human X-linked markers into murine somatic cells via




Induced cell aggregation and mating in Streptococcus faecalis: Evidence for bacterial sex pheromone, 3479

Thymidine kinase and galactokinase genes: Cotransfer by chromosome-mediated gene transfer, 914

Gene, transfer ribonucleic acid Eukaryotic tRNA genes: Specific transcription in Xenopus germinal

vesicle extracts, 4819 Structure of yeast phenylalanine-tRNA genes: Intervening DNA segment

within region coding for tRNA, 190 Transcription of cloned tRNA gene fragments and subfragments injected

into oocyte nucleus of Xenopus laevis, 1176

Subject Index 6373

Gene, transforming Nucleotide sequences related to transforming gene of avian sarcoma

virus are present in DNA of uninfected vertebrates, 4102 Specific RNA sequences and gene products of MC29 avian acute

leukemia virus, 5874 Gene transposition

Transposition of plasmid DNA segments specifying hydrocarbon degradation and their expression in various microorganisms, 3109

Gene, trp5 Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)

controlled by a bacterial insertion element (IS2), 6172 Gene, tuf

Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104 Mutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470 Gene, uvr


Gene, V Idiotypic analysis of antibodies to poly(Glu6?Ala3?Tyr1o): Interstrain and

interspecies idiotypic crossreactions, 6192 Geometric invariant theory

Stability of local rings of dimension 2, 4085 Geophysical fluid dynamics

Global problems of geophysical fluid dynamics (Review), 34 GERL

Cholera toxin: Endocytosis into neuronal GERL, 2815 Cytochemical studies on GERL, provacuoles, and vacuoles in root

meristematic cells of Euphorbia, 852 Germ line theory


Glass fiber filter Filter-binding assay for covalent DNA-protein complexes: Adenovirus

DNA-terminal protein complex, 5291 Glioblastoma

Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus, 3965

Globin see also Gene, globin Age-dependent relaxation of gene repression: Increase of endogenous


Intervening sequence of a mouse /-globin gene is transcribed within 15S g-globin mRNA precursor, 1309

Intervening sequence of DNA identified in structural portion of a mouse ,-globin gene, 725

Globulin, cold-insoluble Attachment and spreading of baby hamster kidney cells to collagen

substrata: Effects of cold-insoluble globulin, 4408 Cold-insoluble globulin: Synthesis by cultured calf endothelial cells, 2621

Glomerulonephritis Anti-interferon globulin inhibits development of glomerulonephritis in

mice infected at birth with lymphocytic choriomeningitis virus, 3413 Glucagon


Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of calcium from exchangeable pool in isolated rat hepatocytes, 2234

Glucocerebrosidase Gaucher disease: Isolation and comparison of normal and mutant

glucocerebrosidase from human spleen tissue, 3970 Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher

disease, 2448 Glucocorticoid


Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by glucocorticoids, 5506

Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: Impairment by glucocorticoids, 3498


Gluconeogenesis Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of

calcium from exchangeable pool in isolated rat hepatocytes, 2234 Glucose

see also Transport, glucose; Transport, sugar Density-dependent regulation of growth of BSC-1 cells in cell culture:

Control of growth by low molecular weight nutrients, 339 Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,

glucose, and epinephrine, 1810 Glucose binding and transport proteins extracted from fast-growing

chicken fibroblasts, 5427 Glucose-induced conformational change in yeast hexokinase, 4848 Glucose metabolism in Escherichia coli: High-resolution 13C nuclear

magnetic resonance studies, 3742 Infection with paramyxoviruses stimulates synthesis of cellular

polypeptides that are also stimulated in cells transformed by Rous sarcoma virus or deprived of glucose, 6120

Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange, 5173

Matrix protein from Escherichia coli membranes fo)rms voltage-controlled channels in lipid bilayers, 3751

Oligosaccharides containing glucose and mannose in glycoproteins of thyroid gland, 1162




6374 Subject Index

Glucose, 2-deoxy- 2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-0-tetradecanoyl phorbol-13-acetate, 5422 Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrients

by quiescent BALB/C3T3 cells, 3859 Glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

Glucose-6-phosphate dehydrogenase deficiency: Biochemical mechanisms, 1979


3-Glucosidase Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher

disease, 2448 B-Glucuronidase (EC 3.2.1.31)

Rat liver microsomal and lysosomal k-glucuronidases differ in both carbohydrate and amino acid compositions, 3080

Gluon Failure of Drell-Yan parton model to account for production of J/I/ in

nucleon-nucleon interactions, 5770 Glutamic-oxaloacetic transaminase

see Aspartate aminotransferase Glutamine

Density-dependent regulation of growth of BSC-1 cells in cell culture: Control of growth by low molecular weight nutrients, 339

Glutamine synthetase (EC 6.3.1.2) Allosteric regulation of monocyclic interconvertible enzyme cascade



Site of adenylylation of glutamine synthetase localized by electron microscopy of enzyme-antibody complex, 5778

Topographical analysis of regulatory and metal ion binding sites on glutamine synthetase from Escherichia coli: 13C and 31p nuclear magnetic resonance and fluorescence energy transfer study, 1255

y-Glutamyl cycle -y-Glutamyl cycle functions in vivo using intracellular glutathione:

Effects of amino acids and selective inhibition of enzymes, 5405 y-Glutamyltransferase (EC 2.3.2.2)

Differences in isoelectric focusing patterns of -y-glutamyl transpeptidase from normal and cancerous rat mammary tissue, 1750

'y-Glutamyl transpeptidase see also y-Glutamyltransferase Serine-borate complex as transition-state inhibitor of -y-glutamyl

transpeptidase, 4806 Glutaraldehyde


Glutaraldehyde fixation Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture


Glutathione Fluorescent light-induced chromosome damage and its prevention in

mouse cells in culture, 1830 -y-Glutamyl cycle functions in vivo using intracellular glutathione:

Effects of amino acids and selective inhibition of enzymes, 5405 Serine-borate complex as transition-state inhibitor of --glutamyl

transpeptidase, 4806 Glutathione, oxidized

Protein synthesis initiation inhibited by oxidized glutathione: Activation of a protein kinase that phosphorylates the a subunit of eukaryotic initiation factor 2, 4110

Glutathione S-transferase B see Glutathione transferase

Glutathione transferase (EC 2.5.1.18) see also Ligandin Growth state-dependent phenotypes of adult hepatocytes in primary

monolayer culture, 1834 Glycan


Glycerol kinase (EC 2.7.1.30) Adenosine 5'-0-([y-l80]'y-thio)triphosphate chiral at the y-phosphorus:

Stereochemical consequences of reactions catalyzed by pyruvate kinase, glycerol kinase, and hexokinase, 2230

Glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) Enzymatic defect in obese (ob/ob) mouse: Loss of thyroid-induced

sodium- and potassium-dependent adenosinetriphosphatase, 477 Glycine

see also Polyglycine Protein tertiary structure: Formation on a computer, 554

Glycine max Mutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343 Glycolysis

Bioenergetics and glycolysis in anaerobic Escherichia coli cells: 31P nuclear magnetic resonance studies, 2244


Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus, 5015

Glycopeptide see also Glycoprotein Carbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315


Growth of transformed cells and tumors inhibited by endogenous acceptor of galactosyltransferase, 4426

Neonate's nonspecific immunity to Klebsiella infection enhanced by muramyl dipeptide, a synthetic immunoadjuvant, 3395

Glycoprotein see also Glycopeptide; Membrane, glycoprotein Activated human T lymphocytes display new surface glycoproteins, 3455 Amino-terminal sequence analysis of structural proteins of Sindbis virus,

2722 Asymmetric budding of viruses in epithelial monolayers: Model system

for study of epithelial polarity, 5071 Bovine protein C: Amino acid sequence of the light chain, 5889 Crossreacting determinants in variant-specific surface antigens of

African trypanosomes, 1989 DNA synthesis in growing BALB/c 3T3 mouse cells controlled by a

fibroblast growth regulatory factor, 6115 Egg surface glycoprotein receptor for sea urchin sperm bindin, 881 Envelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962 Fusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737 Hepatic receptor that specifically binds oligosaccharides containing

fucosyl l-'3 N-acetylglucosamine linkages, 2215 High molecular weight cell surface glycoprotein (LETS protein)


Ia-like antigens: Expression on cultured human malignant inelanoma cell lines, 6235

Insulin receptor: Interaction with nonreceptor glycoprotein from liver cell membranes, 3070

Interferoids: In vitro and in vivo conversion of native interferons to lower molecular weight forms, 4814

Large Ti oligonucleotides of Moloney leukemia virus missing in env gene recombinant, HIX, are present on intracellular 21S Moloney viral RNA species, 2964

Large Tl oligonucleotides of Moloney leukemia virus missing in env gene recombinant, HIX, are present on intracellular 21S Moloney viral RNA species (correction), 5244

Nearest-neighbor interactions of major RNA tumor virus glycoprotein on murine cell surfaces, 3644

Oligosaccharide chains are trimmed during synthesis of envelope glycoprotein of vesicular stomatitis virus, 754


Physical, morphological, and biochemical alterations in membrane of AKR mouse cells after interferon treatment, 1859



Proteases induce secretion of collagenase and plasminogen activator by fibroblasts, 1839

Protein degradation in diabetes and starvation, 2093 Protein micelles formed from amphiphilic membrane proteins, 5306 Rat liver microsomal and lysosomal ,-glucuronidases differ in both

carbohydrate and amino acid compositions, 3080 Receptor-mediated binding of glycoproteins, glycoconjugates, and

lysosomal glycosidases by alveolar macrophages, 1399 Structural polymorphism within amino-terminal region of MM, NN, and

MN glycoproteins (glycophorins) of human erythrocyte membrane, 2727


Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes, 970

Vesicular stomatitis virus membrane glycoprotein: In vitro synthesis and insertion into membranes, 715

Viral proteins in mouse mammary tumors detected by immunoperoxidase staining of paraffin sections, 1524

Glycosaminoglycan Calcium affects structure and function of hyaluronic acid matrix:


Glycosphingolipid Biosynthesis in vitro of fucose-containing glycosphingolipids in human

neuroblastoma IMR-32 cells, 289 Glycosylation



Infection with paramyxoviruses stimulates synthesis of cellular polypeptides that are also stimulated in cells transformed by Rous sarcoma virus or deprived of glucose, 6120

Goiter Abnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74 Golgi vesicle

Different regulation of insulin receptors in intracellular (Golgi) and plasma membranes from livers of obese and lean mice, 3302

Gonadotropin see also Receptor, gonadotropin Gonadotropin binding and stimulation of steroidogenesis in Leydig

tumor cells, 99 Rat oocyte maturation in vitro: Relief of cyclic AMP inhibition by

gonadotropins, 4369




Graft-versus-host reaction Hemopoietic stem cell transplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933 Gram-negative sepsis

Lipid A and endotoxin in serum determined by mass spectroscopy, 3993 Granulocyte

Changes in membrane potential of human granulocytes antecede metabolic responses to surface stimulation, 3818

Gravitational differentiation Global problems of geophysical fluid dynamics (Review), 34

Group selection Group selection on a quantitative character, 3531 Mathematical theory of group selection: Structure of group selection in


Growth see also Cell growth Sterol requirement of Mycoplasma capricolum, 4107

Growth cone Growth cone formation in cultures of sensory neurons, 5226

Growth factor Estrogen induction of growth factors specific for hormone-responsive

mammary, pituitary, and kidney tumor cells, 3786 Growth factors from murine sarcoma virus-transformed cells, 4001 HeLa cells: Growth and maintenance in serum-free medium

supplemented with hormones, 901 Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057 Serum stimulates Na+,K+ pump in quiescent fibroblasts by increasing

Na+ entry, 5560 Growth factor, epidermal

see also Epidermal growth factor-urogastrone Binding and internalization of epidertnal growth factor in human

carcinoma cells A-431: Visualization by fluorescence, 3317 Dexamethasone modulates binding and action of epidermal growth

factor in serum-free cell culture, 1882 Direct visualization of binding, aggregation, and internalization of insulin

and epidermal growth factor on living fibroblastic cells, 2659 Epidermal growth factor: Biological activity requires persistent

occupation of high-affinity cell surface receptors, 5788 Epidermal growth factor: Morphological demonstration of binding,

internalization, and lysosomal association in human fibroblasts, 5025 Fluorescent labeling of hormone receptors in viable cells: Preparation

and properties of highly fluorescent derivatives of epidermal growth factor and insulin, 2135



Growth factor, fibroblast Brain-derived fibroblast growth factor: Identity with a fragment of basic

protein of myelin, 4675 DNA synthesis in growing BALB/c 3T3 mouse cells controlled by a

fibroblast growth regulatory factor, 6115 Growth factor, insulin-like

Insulin-like growth factor: Model for tertiary structure accounting for immunoreactivity and receptor binding, 180

Growth factor, nerve Nerve growth factor: A protease that can activate plasminogen, 5497 Nerve growth factor increases activity of ornithine decarboxylase in rat

brain, 1021 Nerve growth factor-induced fiber outgrowth from isolated rat adrenal

chromaffin cells: Impairment by glucocorticoids, 3498 Nerve growth factor in mouse and rat serum: Correlation between

bioassay and radioimmunoassay determinations, 4042 Nerve growth factor: Intraventricular administration induces ornithine

decarboxylase in peripheral tissues of rat, 2512 Nerve growth factor-mediated induction of' tyrosine hydroxylase in

clonal pheochromocytoma cell line, 4587 Nerve growth factor potentiates actomyosin adenosinetriphosphatase,

2210 RNA synthesis-dependent and -independent pathways in stimulation of

neurite outgrowth by nerve growth factor, 6059 Growth factor, platelet-derived

Coordinate control of 3T3 cell proliferation by platelet-derived growth factor and plasma components, 2810

Ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis, 2839

Growth hormone see Somatotropin

Growth regulation Assay for early cytoplasmic effects of src gene product of Rous sarcoma

virus, 2750 Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 281.0 Diadenosine 5',5"'-P',P4-tetraphosphate triggers initiation of in vitro

DNA replication in baby hamster kidney cells, 371 Increased incorporation of adenosine into adenine nucleotide pools in

serum-deprived mammalian cells, 1145 Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379 Steroid hormones mediate reversible phenotypic transition between

transformed and untransformed states in mouse fibroblasts, 2805 Guanine insertion enzyme

Unique tRNA species detected in tumor tissues by Escherichia coli guanine insertion enzyme, 4247

Subject Index 6375

Guanine nucleotide Cholera toxin-activated adenylate cyclase: Reconstitution, 3113 Guanosinetriphosphatase activity dependent on elongation factor Tu and

ribosomal protein L7/L12, 3192 Interaction of ligands with opiate receptors of brain membranes:

Regulation by ions and nucleotides, 1713 Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993

Guanine, 06-methyl- O6-Methylguanine: Repair in adapted Escherichia coli, 6017

Guanosine 3':5'-cyclic monophosphate Bombesin and litorin interact with specific membrane receptors on

pancreatic acinar cells, 6139 Cyclic GMP associated with gene expression of polytene chromosomes of

Drosophila melanogaster, 1480 Cyclic GMP injected into retinal rod outer segments increases latency

and amplitude of response to illumination, 5218 Cytidine 3':5'-cyclic monophosphate phosphodiesterase activity

depressed in developing tissues of guinea pigs, 4422 Epinephrine-induced elevation of guanosine 3':5'-cyclic monophosphate

in isolated fat cells of rat, 2684 Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate

cyclase activity, cyclic GMP concentration, and ion transport in small intestine, 2800

Inhibition of growth and guanylate cyclase activity of undifferentiated prostate adenocarcinoma by extract of balsam pear (Momordica charantia abbreviata), 989


Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic monophosphate levels in neuroblastoma cells, 6295

Guanosine, 7-methyl- Polypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843 Guanosine nucleotide

Role of nucleotides in tubulin polymerization: Effect of guanosine 5'-methylene diphosphonate, 3178

Guanosine tetraphosphate Guanosine 5'-diphosphate 3'-diphosphate: Mechanism of in vitro

breakdown in Escherichia coli, 4180 Guanosine, 6-thio-

Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling sulfur in nucleic acids, 1181

Guanosinetriphosphatase Guanosinetriphosphatase activity dependent on elongation factor Tu and

ribosomal protein L7/L12, 3192 Guanosine 5'-triphosphate

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: Basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis, 5362

Binding and release of eukaryotic initiation factor eIF-2 and GTP during protein synthesis initiation, 204


Guanylate cyclase (EC 4.6.1.2) Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate

cyclase activity, cyclic GMP concentration, and ion transport in small intestine, 2800


Guanylyl-5'-imidodiphosphate Interaction of fluoride- and guanylyl-5'-imidodiphosphate-regulatory

proteins with adenylate cyclase, 3693 Guanylyl 5'-methylene diphosphonate

Role of nucleotides in tubulin polymerization: Effect of guanylyl 5'-methylene diphosphonate (correction), 1608

Guinea pig Control of antibody heterogeneity in strain 2 guinea pigs, 959 Cytidine 3':5'-cyclic monophosphate phosphodiesterase activity

depressed in developing tissues of guinea pigs, 4422 Gut

Species specificity of cholecystokinin in gut and brain of several mammalian species, 486

Gynura aurantiaca Potato spindle tuber and citrus exocortis viroids undergo no major

sequence changes during replication in two different hosts, 951 RNA sequences complementary to citrus exocortis viroid in nucleic acid

preparations from infected Gynura aurantiaca, 896

Haemophilus influenzae Haemophilus influenzae bacteremia and meningitis resulting from

survival of a single organism, 1534 Hageman factor

see Factor XII Hagfish

see Eptatretus stoutii Hallucinogen


Halobacterium halobium Bacteriorhodopsin: Molecular orientation within the purple membrane of

Halobacterium halobium, 4320 Haloperidol

Multiple receptors for brain dopamine, 1153 Hamster

Photoperiodic regulation of hamster testis: Dependence on circadian rhythms, 1034



6376 Subject Index

Hapten Hapten mimic elicits antibodies recognizing prostaglandin E2, 2689

Hardy-Weinberg model Generalizing Fisher's "reproductive value": Overlapping and

nonoverlapping generations with competing genotypes, 4062 Harish-Chandra module

Algebraic construction and classification of Harish-Chandra modules, 1063

Harman Comutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928 Harmonic analysis

Localization for double Fourier series, 580 Some new singular Fourier-Stieltjes series, 5268

Hearing see also Auditory nerve fiber Sound transmission in salamander ear, 529 Steering responses of flying crickets to sound and ultrasound: Mate

attraction and predator avoidance, 4052 Heart

see also Cardiac; Cell, heart; Membrane, heart Presence of two nonidentical subunits in NAD-dependent isocitrate

dehydrogenase of pig heart, 252 Heat


a Helix Diamagnetic anisotropy and orientation of a helix in frog rhodopsin and

meta II intermediate, 5471 Diamagnetic anisotropy in proteins: Structural origins, 5475

Hemagglutinin see also Phytohemagglutinin Fusion protein of Sendai virus purified: NH2-terminal sequence

generated during precursor activation, 2737 Genetic dimorphism in influenza viruses: Characterization of stably


Heme Heme disorder in hemoproteins: Proton nuclear magnetic resonance

characterization, 5755 Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction of Met-tRNAfMet binding factor with another initiation factor in formation of Met-tRNAfMet-40S ribosomal subunit complexes, 745

Regulation of protein synthesis in rabbit reticulocyte lysates: Purification and characterization of heme-reversible translational inhibitor, 3654

"Tension" on heme by proximal base and ligand reactivity: Conclusions from model compounds for reaction of hemoglobin, 3747

Hemepeptide Two forms of bovine erythrocyte cytochrome b5 are identical to segments

of microsomal cytochrome b5, 3118 Hemin

Hemin-controlled inhibitor of' protein synthesis: Mode of action, 243 Hemin-controlled inhibitor of protein synthesis: Studies with factors

from rabbit reticulocytes, 2713 Hemin: Effect on site-specific phosphorylation of eukaryotic initiation

factor 2, 789 Translational control by hemin is due to binding to cyclic

AMP-dependent protein kinase, 1148 Hemoglobin

Cooperativity in 02 binding to iron porphyrins, 1052 Dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation

inhibited by hydrocortisone and other steroids, 3851 Erythroid colony formation from human fetal liver, 984 Fetal hemoglobin synthesis in baboons stimulated by hemolysis and

hypoxia, 2937 Hemoglobin Lincoln Park: f3I fusion (anti-Lepore) variant with amino

acid deletion in 5 chain-derived segment, 1475 Hemoglobin switching in sheep: Only the y gene is in active

conformation in fetal liver but all the 13 and y genes are in active conformation in bone marrow, 5884

Kinetics of hemoglobin and transition state theory, 2108 Macromolecular transducer as illustrated by trout hemoglobin IV, 4310 Model compounds for T state of hemoglobin, 564 Negative control of hemoglobin production in somatic cell hybrids due to

heme deficiency, 4354 Oxy- and carbonmonoxyhemoglobin: Room-temperature magnetic

properties, 4916 Oxy- and carbonmonoxy hemoglobin: Spectroscopic studies after pulsed

optical excitation, 5255 Oxygen binding by hemoglobin, 5462 Proteolytic activity in erythrocyte precursors, 3427 Reciprocal effects in human hemoglobin: Direct measurement of

dimer-tetramer association constant at partial oxygen saturation, 5493 Self-association of hemoglobin f3H chains is linked to oxygenation, 311 Structure of hemoglobins Zurich [His E7(63)f--Arg] and Sydney [Val

E11(67)3-'Ala] and role of distal residues in ligand binding, 1076 "Tension" on heme by proximal base and ligand reactivity: Conclusions

from model compounds for reaction of hemoglobin, 3747 Hemoglobin, carbon monoxide

Picosecond photodissociation and subsequent recombination processes in carbon monoxide hemoglobin, 573

Hemoglobin S Erythrocytic mechanism of sickle cell resistance to malaria, 1994

Hemolysis Fetal hemoglobin synthesis in baboons stimulated by hemolysis and

hypoxia, 2937


Hemopoiesis Terminal differentiation of human promyelocytic leukemia cells induced

by dimethyl sulfoxide and other polar compounds, 2458 Hemoprotein

Heme disorder in hemoproteins: Proton nuclear magnetic resonance characterization, 5755

Photosensitivity of liganded hemoproteins and their metal-substituted analogues, 21

Hemorrhage Histamine H1- and H2-receptor antagonists: Beneficial and detrimental

actions in circulatory shock, 2941 Heparan sulfate

Sanfilippo syndrome type C: Deficiency of acetyl-CoA:(-glucosaminide N-acetyltransferase in skin fibroblasts, 5185

Heparin Heparin species: Structure-function relationships, 3065

Hepatic fibrosis Lysyl oxidase: Biochemical and immunochemical study in experimental

hepatic fibrosis in rat, 2945 Hepatitis

Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: Nonidentity of e antigen with immunoglobulins, 1952

Suppressor cell activity altered in chronic active hepatitis, 1549 Virus similar to human hepatitis B virus associated with hepatitis and

hepatoma in woodchucks, 4533 Hepatitis virus

Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination, 4033

Hepatocyte Accumulation of a slowly dissociable peptide hormone binding

component by isolated target cells, 672 Endoplasmic reticulum and autophagy in rat hepatocytes, 5039 Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506 Growth state-dependent phenotypes of adult hepatocytes in primary

monolayer culture, 1834 Hepatic receptor that specifically binds oligosaccharides containing

fucosyl l1-'3 N-acetylglucosamine linkages, 2215 Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens,

2864 Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of

calcium from exchangeable pool in isolated rat hepatocytes, 2234 Hepatoma



Nuclear antigens in Novikoff hepatoma: Purification, 1943 Virus similar to human hepatitis B virus associated with hepatitis and

hepatoma in woodchucks, 4533 Herbicide

Herbicide-resistant mutants of Nicotiana tabacum: Direct selection in vitro, 5104

Herpes simplex virus Binding to chromosomes of herpes simplex-related antigens in

biochemically transformed cells, 3288 erythro-9-(2-Hydroxy-3-nonyl)adenine: Specific inhibitor of herpes




T lymphocytes: Role in cellular immune responses during herpes simplex virus infection in humans, 3957

Herpesvirus Endogenous type C virus activated in BALB/c mouse cells by

herpesvirus DNA, 4558 Herpesvirus hexon capsomere: Direct evidence for 6-fold symmetry, 2764 Herpesvirus-specific DNA polymerase isolated from tissues of an

American patient with Burkitt lymphoma, 4504 Heterocyst

Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery in heterocysts isolated from Anabaena variabilis, 6271

Heterozygosity Proteins in natural population: Subunit molecular weight and genetic

variability, 3359 Hexamethylene bisacetamide


Hexokinase (EC 2.7.1.1) Adenosine 5'-O-([y-l80]-y-thio)triphosphate chiral at the -y-phosphorus:


Glucose-induced conformational change in yeast hexokinase, 4848 Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,

hydrocortisone, and dibutyryl cyclic AMP, 1418 Hexosaminidase

see /3-N-Acetylglucosaminidase Hibernation

Existence of a yearly clock in surgically and self-blinded chipmunks, 3517

Hill's stability theory Stability in dynamical astronomy, 5743




Hippocampus -y-Aminobutyric acid receptors: Quantitative visualization in

hippocampus and area dentata demonstrated by [3H]muscimol autoradiography, 2516

Pyramidal cells identified as critical elements in hippocampal neuronal plasticity during learning, 1572

Histamine Histamine H1- and H2-receptor antagonists: Beneficial and detrimental

actions in circulatory shock, 2941 Histamine H1 receptors identified in mammalian brain membranes with

[3H]mepyramine, 6290 Phosphatidylserine: Interaction with mast cells, 4997

Histidine Membrane protein identified as a histidine transport component in

Salmonella typhimurium, 5447 Histochemistry

see also Immunohistochemistry Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263

Histocompatibility see also Antigen, histocompatibility; Major histocompatibility complex Murine complement component 3: Genetic variation and linkage to H-2,

963 Histone



Assembly of new nucleosomal histones and new DNA into chromatin, 2130

Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of associated DNA sequences, 2239

Correlation between phosphorylated HI histones and satellite DNAs in Drosophila virilis, 866

DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for a nuclear factor, 4873

Enzyme from rat liver that cleaves an ADP-ribosyl histone linkage, 2254 Hatching in sea urchin Lytechinus pictus is accompanied by shift in

histone H4 gene activity, 4135 H-1 histone in rat liver nuclei: Displacement and aberrant methylation

vitro after half-saturation of chromatin with polycations, 5773 Histone core complex: Characterization, 1680 Histone HI and H2B production: Species-specific suppression in

human-mouse hybrids, 5599 Histone packing in nucleosome core particle of chromatin, 3649 Nucleosome core particle of chromatin: Sequence of histone arrangement

along DNA, 4184 Histrionicotoxin

Distinct protein components from Torpedo marmorata membranes carry acetylcholine receptor site and binding site for local anesthetics and histrionicotoxin, 510

Histrionicotoxin, perhydro- Differential effects of perhydrohistrionicotoxin on neurally and

iontophoretically evoked endplate currents, 1596 Homogeneous function

Generalizing Fisher's "reproductive value": Overlapping and nonoverlapping generations with competing genotypes, 4062

Homoserine dehydrogenase (EC 1.1.1.3) Refolding of a bifunctional enzyme and its monofunctional fragment,

5979 Honeybee

Amino-acid sequence of honeybee prepromelittin synthesized in vitro, 701

Hormone see also Insect hormone; Receptor, hormone; specific hormones

Hormone, lipolytic Preadipocyte clonal line established from epididymal fat pad of ob/ob

mouse that responds to insulin and to lipolytic hormones, 6054 Hormone, polypeptide

Polypeptide hormones: Chemical determination, 4115 Hubble law

Chronometric cosmology: Redshift-magnitude relation for quasi-stellar objects, 535

Hyaluronic acid Calcium affects structure and function of hyaluronic acid matrix:


Hybrid bond orbital theory Bond angles in transition metal tetracarbonyl compounds: Test of theory


theory of hybrid bond orbitals, 12 Hybrid cell


Chromosomal assignment for a simian virus 40 integration site in human cells, 4460



Genes for immunoglobulin K and heavy chains assigned to chromosomes 6 and 12 in mouse, 4494


Subject Index 6377


Malignancy in human cells: Malignant and transformed phenotypes are under separate genetic control, 1466

Monoclonal antibodies against rabies virus produced by somatic cell hybridization: Detection of antigenic variants, 3938


Repertoire of antiviral antibodies expressed by somatic cell hybrids, 1510 Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320 Temperature-sensitive RNA polymerase II mutations in Chinese hamster

ovary cells, 405 Teratocarcinoma cells as vehicles for introducing specific mutant

mitochondrial genes into mice, 5113 Hybrid cell, mouse-hamster



Hybrid cell, mouse-human Altered pattern of replication of human chromosomes in a human

fibroblast-mouse cell hybrid, 1470 Argininosuccinic aciduria: Assignment of argininosuccinate lyase gene to

pter -- q22 region of human chromosome 7 by bioautography, 6159 Chimeric mice derived from human-mouse hybrid cells, 1914 Chromosomal localization of human Af globin gene on human

chromosome 11 in somatic cell hybrids, 1456 Chromosomal locations of mouse immunoglobulin genes, 2883 Entrapment of metaphase chromosomes into phospholipid vesicles



Epstein-Barr virus and human chromosomes: Close association of resident viral genome and expression of virus-determined nuclear antigen (EBNA) with presence of chromosome 14 in human-mouse hybrid cells, 5155

Genes for human heavy chain immunoglobulin located to chromosome 6, 3367

Genetic analysis of human cell surface: Antigenic marker for human X chromosome in human-mouse hybrids, 2363

Histone HI and H2B production: Species-specific suppression in human-mouse hybrids, 5599

Immunoglobulin secretion from human neoplastic lymphoid cells rescued by somatic cell hybridization, 2411

Hybrid cell, neuroblastoma-glioma Acetylcholine release from neuroblastoma X glioma hybrid cells:

Regulation, 1314 Adenylate cyclase activity: Regulation mediated by muscarinic

acetylcholine receptors, 1788 Hybridization, molecular

Chromosomal locations of mouse immunoglobulin genes, 2883 Duplicated human (a globin genes lie close together in cellular DNA, 5950 Genetic recombination between mouse type C RNA viruses: Mechanism

for endogenous viral gene amplification in mammalian cells, 923 Human tumors and human malignant cell lines analyzed for BK

virus-specific DNA sequences, 454 Mapping of linear and circular forms of mouse mammary tumor virus

DNA with restriction endonucleases: Large specific deletion occurring at high frequency during circularization, 2112

'I'ransfer of duck cell DNA sequences to nucleus of 3T3 cells by Rous sarcoma virus, 4252

Two types of human papillomaviruses in lesions of epidermodysplasia verruciformis, 1537

Hybridization, nucleic acid Mtv-2 gene responsible for early appearance of rhammary tumors in GR

mouse by nucleic acid hybridization, 2368 Hybridization, ribonucleic acid.deoxyribonucleic acid


Age-dependent relaxation of gene repression: Increase of endogenous murine leukemnia virus-related and globin-related RNA in brain and liver of mice, 4431

Immunoglobulin K chain RNA in thymus T cells: Direct demonstration by in situ hybridization, 2905


mRNA populations analyzed by cDNA.mRNA hybrid-mediated inhibition of cell-free protein synthesis, 1217

Polyoma virus giant RNAs contain tandem repeats of nucleotide sequence of entire viral genome, 4754

Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294 Sites of integration of reticuloendotheliosis virus DNA in chicken DNA,

3372 Sodium pyrophosphate inhibition of RNA-DNA hybrid degradation by

reverse transcriptase, 5329 Splicing of avian sarcoma virus 5'-terminal genomic sequences onto

viral-specific RNA in infected cells, 1284 Transcription o(f a defective polyoma virus genome, 69 Two regions of adenovirus 2 genome specify families of late polysomal

RNAs containing common sequences, 625 Viral sequences of low reiteration frequency detected by in situ

hybridization, 6125 Hybrid nuclease

"Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694



6378 Subject Index

Splicing of avian sarcoma virus 5'-terminal genomic sequences onto viral-specific RNA in infected cells, 1284

Hybrid nuclease (EC 3.1.4.34) Purification of ribonuclease H from calf thymus: Simplified method,

4140 Sodium pyrophosphate inhibition of RNA-DNA hybrid degradation by

reverse transcriptase, 5329 Hydra

Regulation of self-renewal probability in Hydra stem cell clones, 886 Hydration


Hydrocarbon Transposition of plasmid DNA segments specifying hydrocarbon

degradation and their expression in various microorganisms, 3109 Hydrocarbon chain order

Deuterium nuclear magnetic resonance investigation of effects of proteins and polypeptides on hydrocarbon chain order in model membrane systems, 4657

Hydrocarbon, polycyclic aromatic Cyclopenta[c,d]pyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667 Polycyclic aromatic hydrocarbons: Dose-dependent preferential binding

to reiterated DNA of murine skin cells in culture, 5841 Transformation of rat embryo cell cultures: Interactions between

adenovirus, a tumor promoter, and chemical carcinogens, 2311 Tumorigenicity of optical enantiomers of the diastereomeric

benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptional activity of (+)-7/,8a-dihydroxy-9n,10(e-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene, 5358

Hydrocarbon, polynuclear aromatic Human bronchus-mediated mutagenesis of mammalian cells by

carcinogenic polynuclear aromatic hydrocarbons, 2003 Hydrocortisone




Hydrodynamics Derivation of linear irreversible thermodynamics for classical fluids, 1632

Hydrogenase see also Ferredoxin hydrogenase Hydrogenase activity expressed in free-living Rhizobium japonicum,

3258 Hydrogen bond

Energies of polypeptides: Theoretical conformational study of polyglycine using quantum mechanical partitioning, 2071

Hydrogen evolution Nitrogenase and nitrogenase reductase associate and dissociate with each

catalytic cycle, 2699 Hydrogen peroxide

Hydrogen peroxide production, chemiluminescence, and respiratory burst of fertilization: Interrelated events in early sea urchin development, 3183

Oxidation of methionine residues of Escherichia coli ribosomal protein L12 decreases the protein's biological activity, 5349

Hydrophobic interaction Macromolecular shape and surface maps by solvent exclusion, 303

Hydroxamate Siderophore electrochemistry: Relation to intracellular iron release

mechanism, 3551 Hydroxymethylglutaryl-CoA reductase


Hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) Cholesterol biosynthesis in HeLa S3G cells regulated by serum



3-Hydroxy-3-methylglutaryl coenzyme A reductase: Regulation of enzymatic activity by phosphorylation and dephosphorylation, 3678


fl-Hydroxymyristic acid Lipid A and endotoxin in serum determined by mass spectroscopy, 3993

5-Hydroxytryptamine see Serotonin

Hyperbilirubinemia Spin assay for reserve bilirubin loading capacity of human serum, 1542

Hypercohomology Second Leray spectral sequence of relative hypercohomology, 4666

Hyperglycemia Influence of hyperinsulinemia, hyperglycemia, and the route of glucose

administration on splanchnic glucose exchange, 5173 Hyperinsulinemia

Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange, 5173

Hypertension see also Blood pressure Arterial collagen: Increased turnover in hypertensive rats, 451 Calcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertensive rat, 1605 Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623



Hypophysectomy Extrahypophysial distribution of corticotropin as function of brain size,

994 Specific regulation by steroid hormones of amount of type I cyclic

AMP-dependent protein kinase holoenzyme, 223 Hypothalamus

Dense plexus of substance P immunoreactive nerve terminals in eminentia medialis of primate hypothalamus, 1013


Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus, 4509

Hypoxanthine phosphoribosyltransferase Purine metabolism in cultured human fibroblasts from patients deficient


Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) Chimeric mice derived from human-mouse hybrid cells, 1914 Somatic cell hybrids producing antibodies specific for tumor antigen of

simian virus 40, 2320 Hypoxia

Fetal hemoglobin synthesis in baboons stimulated by hemolysis and hypoxia, 2937

31p nuclear mangetic resonance signals in brain detected by in vivo and freeze-trapped assays, 4925

Hysteresis Hysteresis effects of C1H4 and C2H4 in regions of solid-phase transitions,

4664

Idiotype Idiotypic analysis of antibodies to poly(Glu6eAla3oTyrml): Interstrain and

interspecies idiotypic crossreactions, 6192 Immune complex

Changes in membrane potential of human granulocytes antecede metabolic responses to surface stimulation, 3818

Immune response Envelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962 Secondary cytotoxic T lymphocytes induced by purified HLA-A and

HLA-B antigens reconstituted into phospholipid vesicles, 5688 Specificity and crossreactivity of idiotypes of murine antibodies induced

by poly(Tyr,Glu)-poly(DLAla)-poly(Lys) and poly(Phe,Glu)-poly(DLAla)-poly(Lys), 5118


Immune suppression Regulation of antibody heterogeneity by suppressor T cells: Diminishing


Immune system T-cell helper function: Regeneration in zinc-deficient adult mice, 5660

Immune system, secretory Hormonal induction of secretory immune system in mammary gland,

2928 Immunity

Bacteriophage P1 immunity analyzed by using X-P1 recombinants constructed in vitro, 5594

Immunity, cell-mediated Degradation of basic protein in myelin by neutral proteases secreted by

stimulated macrophages: Possible mechanism of inflammnatory demyelination, 1554

Systemic bacillus Calmette-Guerin (BCG) activates natural suppressor cells, 5142

Translation of mRNA from calf thymus in wheat germ system: Evidence for precursor of thymosin (Y, 6007

Immunity, humoral Trypanosome-mediated suppression of humoral immunity in mice:

Mechanisms, 3923 Immunoadjuvant


Immunocytochemistry Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture


Neurons containing /3-endorphin in rat brain exist separately from those containing enkephalin: Immunocytochemical studies, 1591

Pituitary somatotrophs contain [Metjenkephalin-like immunoreactivity, 6134

Ultrastructural antibody localization of (^2-macroglobulin in membrane-limited vesicles in cultured cells, 4359

Unaltered structure and in vivo assembly of microtubules in transformed cells, 1339

Immunodeficiency see also Combined immunodeficiency disease Deoxyadenosine triphosphate as a potentially toxic metabolite in

adenosine deaminase deficiency, 472 Milk precipitins, circulating immune complexes, and IgA deficiency, 3387 Purine metabolism in cultured human fibroblasts from patients deficient



Immunodeficiency disease Gene on human chromosome 6 functions in assembly of tissue-specific

adenosine deaminase isozymes, 3876




Immunoelectron microscopy Computerized multidimensional scaling used to compare


Immunoelectrophoresis Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506 Fibronectin is the collagen receptor on platelet membranes, 5864 Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679 Membrane vesicles from Escherichia coli: Molecular structure, 3148

Immunoferritin Acetylcholine receptor localized in excitable membrane from electric



Immunofluorescence see also Fluorescence Actin may be present on lymphocyte surface, 4484 Antigenic phospholipids introduced into plasma membrane of

mammalian cells: Organization and antibody-induced lipid redistribution, 5529

Assay for early cytoplasmic effects of src gene product of Rous sarcoma virus, 2750


Colonlic tissue-bound antibodies: Isolation and characterization from patients with idiopathic ulcerative colitis, 4528



Cyclic GMP associated with gene expression of polytene chromosomes of Drosophila melanogaster, 1480



Differences among 100-A filament subunits from different cell types, 4364

Different intermediate-sized filaments distinguished by immunofluorescence microscopy, 5034


Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548 Genetic analysis of human cell surface: Antigenic marker for human X

chromosome in human-mouse hybrids, 2363 High molecular weight cell surface glycoprotein (LETS protein)


Histocompatibility antigens participate in capping of molecularly independent cell surface components by their specific antibodies, 2406

Immunofluorescent localization of a serine protease in rat small intestine, 2785

a-Melanocyte stimulating hormone: Immunohistochemical identification and mapping in neurons of rat brain, 6300

Microtubule assembly-disassembly controlled by calcium-dependent regulator protein, 3771

Mitochondria are associated with microtubules in cultured cells, 3863 Monoclonal antibody defining a stage-specific mouse embryonic antigen

(SSEA-1), 5565 Monovalent antibodies against MM-creatine kinase remove M line from

myofibrils, 4296 THY-1: Differentiation marker of potential mammary myoepithelial cells

in vitro, 6093 Transformation-dependent secretion of low molecular weight protein by

murine fibroblasts, 2767 Translation of animal virus RNA in cytoplasm of plant cell, 5557

Immunogenicity Envelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962

Immunoglobulin see also Cryoimmunoglobulin; Gene, immunoglobulin Antigen-induced antibody biosynthesis from antibody precursors, the

heavy and light immunoglobulin chains, 2434 Blocking of primary in vitro antibody responses to thymus-independent


Cell adhesion to substrates containing adsorbed or attached IgG, 1366 Cold pepsin digestion: Method to produce Fv fragment from human

immunoglobulin M, 2649 Complete amino-acid sequence of C2 heavy chain of human IgA2

immunoglobulin of A2m(2) allotype, 966 Duality of hepatitis B e antigen in serum of persons infected with

hepatitis B virus: Nonidentity of e antigen with immunoglobulins, 1952


Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679 Immunoglobulin secretion from human neoplastic lymphoid cells rescued

by somatic cell hybridization, 2411 Milk precipitins, circulating immune complexes, and IgA deficiency, 3387 Myeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901

Subject Index 6379

Restricted classes of immunoglobulin produced by lymphoid cell line from patient with agammaglobulinemia, 2421


Small circular DNAs: Change in quantity and size distribution during development of chicken bursa, 5855

Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations, 5137

Variable region genes for immunoglobulin framework are assembled from small segments of DNA: A hypothesis, 2429

Immunoglobulin heavy chain Genes for human heavy chain immunoglobulin located to chromosome 6,

3367 Organization of immunoglobulin heavy chain genes and allelic deletion

model, 2140 Sequence variation among heavy chains from inulin-binding myeloma

proteins, 1957 Tuftsin (an Ig-associated tetrapeptide) triggers immunogenic function of

macrophages: Implications for activation of programmed cells, 3400 Immunoglobulin light chain

X2 Light chains in normal mouse immunoglobulins, 1495 Sequence of a mouse germ-line gene for variable region of

immunoglobulin light chain, 1485 Variable and constant regions are separated in 10-kbase transcription

unit coding for immunoglobulin K light chains, 6044 Immunohistochemistry

see also Histochemistry Tyrosine hydroxylase and catecholamines: Ontogenetic appearance and

disappearance in rat embryo, 2986 Viral proteins in mouse mammary tumors detected by

immunoperoxidase staining of paraffin sections, 1524 Immunological screening

Immunological screening method to detect specific translation products, 2746

Immunology Control of antibody heterogeneity in strain 2 guinea pigs, 959

Immunoperoxidase Viral proteins in mouse mammary tumors detected by

immunoperoxidase staining of paraffin sections, 1524 Immunoprecipitation

Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells, 2488

Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and uricase, 5066

DNAs of simian virus 40 and polyoma direct synthesis of viral tumor antigens and capsid proteins in Xenopus oocytes, 6073

Estrogen control of prolactin synthesis in vitro, 5946 ]Expression of simian virus 40 early genes in transformed rat cells is

correlated with maintenance of transformed phenotype, 4987 Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749 Molecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674 Murine Ia and human DR antigens: Homology of amino-terminal

sequences, 3953 Polyoma virus T antigens translated in vitro, 5917 Polypeptide encoded by avian sarcoma virus src gene: Identification,

1567 Primary structure of murine major histocompatibility complex

alloantigens: Isolation, biochemical characterization, and preliminary alignment of CNBr fragments from H-2Kb glycoprotein, 2909

Primary structure of murine major histocompatibility complex alloantigens: Amino acid sequence studies of cyanogen bromide fragments of H-2Kb glycoprotein, 3:390

Primate papovavirus tumor antigens: Common methionine-tryptic peptides near amino-terminal end, 1131

Protein kinase activity associated with avian sarcoma virus src gene product, 2021

Regulation of galactose pathway in Saccharomyces cerevisiae: Induction of uridyl transferase mRNA and dependency on GAL4 gene function, 2878

Immunoreactivity (i-Endorphin-like immunoreactivity appears in human ventricular

cerebrospinal fluid upon analgesic electrical stimulation, 5170 Immunoregulation

Adult murine T cells activated in vitro by a(-fetoprotein and naturally occurring T cells in newborn mice: Identity in function and cell surface differentiation antigens, 2897

Immunosorbent assay Immunodiagnosis of infection with Schistosoma mansoni:

Enzyme-linked immunosorbent assay for detection of antibody to circulating antigen, 5715

Immunosuppression Specific immunosuppression of experimental autoimmune myasthenia

gravis by denatured acetylcholine receptor, 4006 Inbreeding

Inbreeding: Effect on IQ and mental retardation, 3906 Indefinite hypergeometric summation

DI)ecision procedure for indefinite hypergeometric summation, 34 Indoleamine 2,3-dioxygenase

Pulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal injection of bacterial lipopolysaccharide, 3998

Indole triplet absorption spectrum Flash photolysis of human serum albumin: Characterization of indole

triplet absorption spectrum and decay at ambient temperature, 1172 Indomethacin

Indomethacin: Low concentrations inhibit phospholipase A2 of rabbit polymorphonuclear leukocyte, 2955



6380 Subject Index

Inflammation Indomethacin: Low concentrations inhibit phospholipase A2 of rabbit

polymorphonuclear leukocyte, 2955 Influenza

Repertoire of antiviral antibodies expressed by somatic cell hybrids, 1510 influenza virus

Biochemical evidence that "new" influenza virus strains in nature may arise by recombination (reassortment), 3341

Genetic dimorphism in influenza viruses: Characterization of stably associated hemagglutinin mutants differing in antigenicity and biological properties, 6258

Globin mRNAs are primers for transcription of influenza viral RNA in vitro, 4886

Influenza virus proteins: Identity, synthesis, and modification analyzed bv two-dimensional gel electrophoresis, 3625

Infrared absorption Structure of hemoglobins Zurich [His E7(63)/--.Arg] and Sydney [Val

E11(67)O-*AlaJ and role of distal residues in ligand binding, 1076 Initiation factor

Hemin-controlled inhibitor of protein synthesis: Studies with factors from rabbit reticulocytes, 2713

Regulation of protein synthesis in rabbit reticulocyte lysates by heme-regulated protein kinase: Inhibition of interaction of Met-tRNAfet binding factor with another initiation factor in formation of Met-tRNAfmet-40S ribosomal subunit complexes, 745

Initiation factor, eukaryotic Binding and release of eukaryotic initiation factor eIF-2 and GTP during,

protein synthesis initiation, 204 Eukaryotic initiation factor 3 localized on native small ribosomal

subunits, 1389 Hemin-controlled inhibitor of protein synthesis: Mode of action, 243 Hemin: Effect on site-specific phosphorylation of eukaryotic initiation

factor 2, 789 Inhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732 Interferon action: Two distinct pathways for inhibition of protein

synthesis by double-stranded RNA, 5893 Phosphorylation of eukaryotic protein synthesis initiation factors, 108 Polypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843 Protein synthesis initiation inhibited by oxidized glutathione: Activation

of a protein kinase that phosphorylates the (a subunit of eukaryotic initiation factor 2, 4110

Protein synthesis in rabbit reticulocytes: A ribosomal factor that reverses inhibition of protein synthesis in heme-deficient lysates, 4858

Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2, 1121


Translational control: Recognition of methylated 5' end and an internal sequence in eukaryotic mRNA by the initiation factor that binds methionyl-tRNAet, 650

Inositol Myoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568 Replica plating and in situ enzymatic assay of animal cell colonies

established on filter paper, 1190 Insect

Geometric model describing quasi-equilibrium of energy flow in populations of stream insects, 381

Insect hormone see also specific hormones Specificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone I, 185 Insertion sequence element


Nucleotide sequence of an insertion element, IS1, 615 Insulin

see also Preproinsulin; Proinsulin; Receptor, insulin Albumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879 Anti-idiotypic antibodies used as cell-surface receptor probes, 2443 Dexamethasone modulates binding and action of epidermal growth

factor in serum-free cell culture, 1882 Direct visualization of binding, aggregation, and internalization of insulin

and epidermal growth factor on living fibroblastic cells, 2659 Fluorescent labeling of hormone receptors in viable cells: Preparation


Genes for human insulin: Chemical synthesis, 5765 Glutamine synthetase in cultured 3T3-L1 cells regulated by insulin,

hydrocortisone, and dibutyryl cyclic AMP, 1418 Growth hormone modulation of murine erythroleukemia cell growth in

vitro, 3437 Insulin and epidermal growth factor-urogastrone: Affinity crosslinking to

specific binding sites in rat liver membranes, 1675 Insulin binding to solubilized material from fat cell membranes:

Evidence for two binding species, 2593 Insulin identified in rat brain, 5737 Insulin resistance due to a defect distal to insulin receptor:

Demonstration in patient with leprechaunism, 3469 Lateral diffusion coefficients of hormone-receptor complexes of insulin


Preadipocyte clonal line established from epididymal fat pad of ob/ob mouse that responds to insulin and to lipolytic hormones, 6054


Receptor crosslinking or aggregation is important in insulin action, 4209 Xenopus oocytes: Long-term growth and differentiation in a defined

medium, 5534 Insulin-like activity

Insulin-like growth factor: Model for tertiary structure accounting for immunoreactivity and receptor binding, 180

Insulinoma Major polyadenylylated transcription products and the genes active in

their synthesis in a rat insulinoma identified, 3249 Intercellular bridge

Intercellular bridge from cultured mouse cells: Partial purification and characterization, 4977

Interface Brilliant total reflection from a liquid-liquid interface, 5772

Interferoid Interferoids: In vitro and in vivo conversion of native interferons to

lower molecular weight forms, 4814 Interferon

Anti-interferon globulin inhibits development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus, 3413

Does 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in oocytes of Xenopus laevis? 5030

Interferoids: In vitro and in vivo conversion of native interferons to lower molecular weight forms, 4814

Interferon action: Two distinct pathways for inhibition of protein synthesis by double-stranded RNA, 5893

Isolation of two interferon-induced translational inhibitors: A protein kinase and an oligo-isoadenylate synthetase, 4734

Mammalian lectin-like substance: Isolation, preliminary characterization, and interferon antagonistic effect, 2333

[2-Microglobulin and HLA antigens: Enhanced expression on human lymphoid cells by interferon, 6215

Oligonucleotide inhibitor of protein synthesis made in extracts of interferon-treated chick embryo cells: Comparison with mouse low molecular weight inhibitor, 1167


pppA2'p5'A2'p5'A: Inhibitor of protein synthesis synthesized with enzyme fraction from interferon-treated cells, 256


Inversion problem Inversion problem for singular integral operators: C*-approach, 4668

Iodine Silane/iodine-based cleavage of esters and ethers under neutral

conditions, 4 Iodine-125

Actin may be present on lymphocyte surface, 4484 Potato spindle tuber and citrus exocortis viroids undergo no major

sequence changes during replication in two different hosts, 951 Ion

see also Transport, ion Ion channel

Decamethonium both opens and blocks endplate channels, 2994 Ion flow

Acetylcholine-receptor-mediated ion flux in electroplax membrane microsacs (vesicles): Change in mnechanism produced by asymmetrical distribution of sodium and potassium ions, 1703

Ion flow through a membrane: Concentration and current responses to a step potential change, 1612

Ion flow through a membrane: Effect of chemical reaction on time dependence, 2064

Ionic current In vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776 Ionic strength

Chromatin subunit: Conformational changes, 660 lonophore

Calcitonin and calcium ionophores: Cyclic AMP responses in cells of a human lymphoid line, 3984

Electrotonic synapses uncoupled by calcium, 4577 Fluorescence probe measurement of intralysosomal pH in living cells and

perturbation of pH by various agents, 3327 lonophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Low molecular weight Ca2+ carrier isolated from calf heart inner

mitochondrial membrane, 2125 Macrophage tumoricidal capability modulated by polyene antibiotics:

Support for membrane lipid as a regulatory determinant of macrophage function, 4349




Transmembrane ion gradients: Effect on Raman spectra of sealed, hemoglobin-free erythrocyte membrane vesicles, 5478

Ion pair Paired ions: Dipolar pairs as subset of diffusion pairs, 16

Iontophoresis Cyclic GMP injected into retinal rod outer segments increases latency

and amplitude of response to illumination, 5218 Ion transfer

Complex III of mitochondrial electron transfer chain: Resolution into two component complexes, 5377

Cytochrome oxidase resolved into two component complexes, 5908




IQ Diet, genetics, and mental retardation interaction between


Inbreeding: Effect on IQ and mental retardation, 3906 Irehdiamine

Does irehdiamine kink DNA? 4286 Iron

see also Protein, iron--sulfur Bond angles in transition metal tetracarbonyl compounds: Test of theory


theory of hybrid bond orbitals, 12 Iron, an essential element for biosynthesis of aromatic compounds, 4810 Plasma radioiron kinetics in man: Explanation for effect of plasma iron

concentration, 1559 Separation of younger red cells with improved survival in vivo: Approach

to chronic transfusion therapy, 3474 Siderophore electrochemistry: Relation to intracellular iron release

mechanism, 3551 Irradiation

Fluorescent light-induced DNA crosslinkage and chromatid breaks in mouse cells in culture, 3809

Irradiation, ultraviolet Antagonists of DNA gyrase inhibit repair and recombination of

UV-irradiated phage A, 4125 Bacteriophage T7 DNA: Marker rescue and partial replication, 6144 Carcinogens enhance survival of UV-irradiated simian virus 40 in treated

moinkey kidney cells: Induction of a recovery pathway? 346 Cell-free assay measuring repair DNA synthesis in human fibroblasts,

1887 DNA unwinding induced by photoaddition of psoralen derivatives and






Ouabain-resistant mutations induced in C3H IOT1/2 mouse cells by ultraviolet light, 3363



Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation, 1984

Irradiation, x- X-ray sensitivity of diploid fibroblasts from patients with hereditary or

sporadic retinoblastoma, 3962 Ising system


Interacting enzyme systems at steady state: Further Monte Carlo calculations on two-state molecules, 5260

Isocitrate dehydrogenase (NADP+) (EC 1.1.1.41) Presence of two nonidentical subunits in NAD-dependent isocitrate

dehydrogenase of pig heart, 252 Isoelectric focusing


Mammalian cytoplasmic actins are products of at least two genes and differ in primary structure in at least 25 identified positions from skeletal muscle actins, 1106

Plasmodium knowlesi-induced antigens in membranes of parasitized rhesus monkey erythrocytes, 4949

Purification of ribonuclease H from calf thymus: Simplified method, 4140

Isoenzyme see Isozyme

Isoleucine Physical organization of ilvEDAC genes of Escherichia coli strain K-12,

89 Isoproterenol


Isozyme Differences in isoelectric focusing patterns of -y-glutamyl transpeptidase

from normal and cancerous rat mammary tissue, 1750 Electrophoretic shift mutants in Chinese hamster ovary cells: Evidence

for genetic diploidy, 1919 Growth state-dependent phenotypes of adult hepatocytes in primary

monolayer culture, 1834 Human adenosine deaminase expressed after fusion of adenosine

deaminase-deficient cells with mouse fibroblasts, 936 Iron, an essential element for biosynthesis of aromatic compounds, 4810 Purification of ribonuclease H from calf thymus: Simplified method,


disguised by cofactor and subunit binding, 395

Subject Index 6381

Jaundice Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer of

microsomal mixed-function monooxygenases, 682 Spin assay for reserve bilirubin loading capacity of human serum, 1542

JC virus Primate papovavirus tumor antigens: Common methionine-tryptic

peptides near amino-terminal end, 1131 Juvenile hormone binding protein

Specificity of juvenile hormone binding protein: Geometrical isomers of juvenile hormone 1, 185

Juvenile hormone I Specificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone I, 185

Kainic acid Ontogenetic development of kainate neurotoxicity: Correlates with

glutamatergic innervation, 2025 Kallikrein

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII), 1998

Karyotype Transforming activity of Epstein-Barr virus obtained by superinfection

of Raji cells, 2008 Keratin

Ten-nanometer filaments of hamster BHK-21 cells and epidermal keratin filaments have similar structures, 6098

ae-Ketoglutarate Prolyl hydroxylase half reaction: Peptidyl prolyl-independent

decarboxylation of a(-ketoglutarate, 2145 Kinetics

see also Enzyme kinetics; Oxygen exchange kinetics Receptor-controlled tracer efflux from sealed membrane fragments:

Kinetic analysis, 3756 Stochastic theory of ligand migration in biomolecules, 26

Kinetics, association Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,

and subfragments of myosin, 54 Kinetics, decay

Flash photolysis of human serum albumin: Characterization of indole triplet absorption spectrum and decay at ambient temperature, 1172


Kinetics, relaxation Does irehdiamine kink DNA? 4286

Kinetic theory Derivation of linear irreversible thermodynamics for classical fluids, 1632

Kininogen Role of surface in surface-dependent activation of Hageman factor

(blood coagulation Factor XII), 1998 Kin selection

Altruism: Its characteristics and evolution, 385 Kin selection: A classical approach and a general solution, 6154 Model of kin selection for an altruistic trait considered as a quantitative

character, 420 Klebsiella pneumoniae


Kuru Unusual resistance to ionizing radiation of the viruses of kuru,

Creutzfeldt-Jakob disease, and scrapie, 6268

Laccase see Monophenol monooxygenase

a.Lactalbumin Coupled cell-free synthesis, segregation, and core glycosylation of a

secretory protein, 2338 a-Lactalbumin mRNA in 4-day lactating rat mammary gland, 4739

Lactation Hormonal induction of secretory immune system in mammary gland,

2928 Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057 Lactose and major milk proteins are present in secretory vesicle-rich

fractions from lactating mammary gland, 5020 Lactic acid


Lactoferrin Hepatic receptor that specifically binds oligosaccharides containing

fucosyl al-'3 N-acetylglucosamine linkages, 2215 Lactose

Lactose and major milk proteins are present in secretory vesicle-rich fractions from lactating mammary gland, 5020

Lacunary sequence Differentiation in lacunary directions, 1060

Laplace transform Ion flow through a membrane: Concentration and current responses to a

step potential change, 1612 Larval fat body

Ecdysone-inducible functions of larval fat bodies in Drosophila, 5570 Laser

Coherent stimulated light emission (lasing) in covalently linked chlorophyll dimers, 2076

Laser Raman evidence for new cloverleaf secondary structures for eukaryotic 5.8S RNA and prokaryotic 5S RNA, 4901

Oxy- and carbonmonoxy hemoglobin: Spectroscopic studies after pulsed optical excitation, 5255

Photoprocesses in covalently linked pyrochlorophyllide dimer: Triplet state formation and opening and closing of hydroxylic linkages, 2563



6382 Subject Index

a-Latrotoxin Release of neurotransmitters and depletion of synaptic vesicles in

cerebral cortex slices by a(-latrotoxin from black widow spider venom, 4016

Lattice, colored Colored lattices, 5264 Rotational symmetry: Effect on colored lattices, 5751

Lattice, mnonarithmetic Existence of a nonarithmetic lattice in SU (2,1), 3029

Learning Conditioned behavior of rats modified by neurohypophyseal hormones

and analogues, 2493 Pyramidal cells identified as critical elements in hippocampal neuronal

plasticity during learning, 1572 Least squares

Adaptive design in regression and control, 586 Strong consistency of least squares estimates in multiple regression, 3034

Lecithin, dimyristoyl Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithinl, 5955 Lectin

see also specific lectins Changes in three-dimensional structure of concanavalin A upon

demetallization, 2286 Common ancestor for concanavalin A and lentil lectin? 1136 Diphtheria toxin has properties of a lectin, 261 Hemopoietic stem cell transplantation using mouse bone marrow and

spleen cells fractionated by lectins, 2933 Mammalian lectin-like substance: Isolation, preliminary characterization,

and interferon antagonistic effect, 2333 Susceptibility to mitogens retained after direct dansylation of viable

human lymphocytes, 3766 Legume

Hydrogenase activity expressed in free-living Rhizobium japonicum, 3258

Leishmaniasis Therapy of leishmaniasis: Superior efficacies of liposome-encapsulated

drugs, 2959 Lemna gibba

Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749 Lens





Lens culinaris Common ancestor for concanavalin A and lentil lectin? 1136

Lentil see Lens culinaris

Leprechaunism Insulin resistance due to a defect distal to insulin receptor:

Demonstration in patient with leprechaunism, 3469 Leray spectral sequence

Second Leray spectral sequence of relative hypercohomology, 4666 Lesch-Nyhan syndrome

Purine metabolism in cultured human fibroblasts from patients deficient in hypoxanthine phosphoribosyltransferase, purine nucleoside phosphorylase, or adenosine deaminase, 3722

Leukemia see also Cell, leukemia; Cell, leukemic; Cell, myeloid leukemic; Cell,

promyelocytic leukemia; Erythroleukemia Abelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918 Azo dyes prevent hydrocarbon-induced leukemia in rat, 4524 Growth hormone modulation of murine erythroleukemia cell growth in

vitro, 3437 Leukemia in AKR mice: Defined suppressor cell population expressing

membrane-associated DNA, 6211 Leukemia, chronic lymphocytic

Immunoglobulin secretion from human neoplastic lymphoid cells rescued by somatic cell hybridization, 2411


Leukemia, lymphocytic Differences in behavior and prognosis between leukemic and



Leukemia, mouse Generation of oncogenic type C viruses: Rapidly leukemogenic viruses

derived from C3H mouse cells in vivo and in vitro, 2468 Leukemia virus, avian

Specific RNA sequences and gene products of MC29 avian acute leukemia virus, 5874

Leukemia virus, Friend Changes in genome composition of Friend virus complex in




Leukemia virus, Moloney Large Tl oligonucleotides of Moloney leukemia virus missing in enu gene

recombinant, HIX, are present on intracellular 21S Moloney viral RNA species, 2964



Leukemia virus, murine Abelson antigen: Viral tumor antigen that is also a differentiation

antigen of BALB/c mice, 3918 Abelson murine leukemia virus-encoded protein present in transformed

fibroblast and lymphoid cells, 2488 Age-dependent relaxation of gene repression: Increase of endogenous


Amino- and carboxyl-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus, 1404

Antibody response of mice to chemically induced tumors, 955 Cells nonproductively transformed by Abelson murine leukemia virus

express a high molecular weight polyprotein containing structural and nonstructural components, 3974

Endogenous RNA tumor viruses are activated during chemical induction of murine plasmacytomas, 4549

Infectious murine leukemia virus from DNA of virus-negative AKR mouse embryo cells, 5539

Oncogenic potency of mouse leukemia virus (Gross): Relative loss after prolonged propagation in tissue culture, 3989

RNase Tl-resistant oligonucleotides derived from genomes of Akv and MCF murine leukemia viruses: Characterization and mapping, 495

Selective association of' murine T lymphoblastoid cell surface alloantigens with Mycoplasma hyorhinis, 4479

Structural markers on core protein p30 of murine leukemia virus: Functional correlation with Fv-1 tropism, 4170

Transfection of Fv-1 permissive and restrictive mouse cells with integrated DNA of murine leukemia viruses, 1451

Leukemia virus, Rauscher Biosynthesis of reverse transcriptase from Rauscher murine leukemia


Leukocyte see also Granulocyte 2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-0-tetradecanoyl phorbol-13-acetate, 5422 Indomethacin: Low concentrations inhibit phospholipase A2 of rabbit

polymorphonuclear leukocyte, 2955 Proliferative response to alloantigen amplified by factor present in

extract of syngeneic thymic lymphoid cells, 4474 Specific C5a receptor demonstrated on intact human polymorphonuclear

leukocytes, 3943 Levodopa

see Dopa Ligand

"Tension" on heme by proximal base and ligand reactivity: Conclusions from model compounds for reaction of hemoglobin, 3747

Ligand binding Changes in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818 Kinetics of hemoglobin and transition state theory, 2108 Ligand-dependent conformational changes in trypsin-solubilized and in

membrane particle-constrained acetylcholinesterase: Functional consequences, 3613



Receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages, 1399

Self-association of hemoglobin 3SH chains is linked to oxygenation, 311 Structure of hemoglobins Zurich [His E7(63)/->Arg] and Sydney [Val

E11(67)/-*Ala] and role of distal residues in ligand binding, 1076 Volatile anesthetic facilitation of in vitro desensitization of

membrane-bound acetylcholine receptor from Torpedo californica, 4563

Ligandin see also Glutathione transferase Ligandin retains and albumin loses bilirubin binding capacity in liver

cytosol, 1213 Ligand migration

Stochastic theory of ligand migration in biomolecules, 26 Ligand, nicotinic

Physicochemical properties of triphosphoinositide altered by nicotinic ligands, 784

Light see also Brillouin light scattering; Dynamic light scattering Genetic recombination in Escherichia coli treated with psoralen and

light: Topography and kinetics, 2373 Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749

Limb bud, embryonic chicken Parathyroid hormone- and calcitonin-activated adenylate cyclases:


Limbic epileptiform activity f-Endorphin induces nonconvulsive limbic seizures, 5221

Limit theorem Limit theorems for weighted sums and stochastic approximation

processes, 1068




Linear hypothesis Dose-response curves and competing risks, 4087

Linear recurrence Decision procedure for indefinite hypergeometric summation, 34

Linkage value Multilocus recombination distributions: Classifications and comparisons,

6332 Linking number

Decomposition of linking number of a closed ribbon: Problem from molecular biology, 3557

Lipid see also Phospholipid Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effects

on liver surface membrane lipid structure and function, 4130 Brillouin light scattering measurement of elastic properties of aligned

multilamella lipid samples, 1792 Immobilized lipid in acetylcholine receptor-rich membranes from

Torpedo marmorata, 4329 Transport of long-chain fatty acids by Escherichia coli: Mapping and

characterization of mutants in fadL gene, 3377 Lipid A


Lipid A and endotoxin in serum determined by mass spectroscopy, 3993 Lipid bilayer

Gel to liquid crystal transition of synthetic phosphatidylcholines, 2258 Geometric packing constraints in egg phosphatidylcholine vesicles, 308 Matrix protein from Escherichia coli membranes forms

voltage-controlled channels in lipid bilayers, 3751 Molecular motion in membranes determilled using periodic pattern

photobleaching, 2759 Photochemical technique for measuring lateral diffusion of spin-labeled

phospholipids in membranes, 4661 Protein-lipid interactions in bilayer membranes: Theoretical study, 1616

Lipid storage disease AB variant of infantile GM2 gangliosidosis: Deficiency of factor necessary


Lipid vesicle Specific antibody and Clq binding to hapten-sensitized lipid vesicles


hapten-sensitized lipid vesicles, 1515 Lipoate acetyltransferase (EC 2.3.1.12)

Rapid intramolecular coupling of active sites in pyruvate dehydrogenase complex of Escherichia coli: Mechanism for rate enhancement in a multimeric structure, 5386

Lipogenic enzymes Preadipocyte clonal line established from epididymal fat pad of ob/ob

mouse that responds to insulin and to lipolytic hormones, 6054 Lipoic acid


Lipolysis Formation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519 Lipopolysaccharide

Bone marrow colony-stimulating factor and tumor resistance-enhancing activity of postendotoxin mouse sera, 2893



Pulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal injection of bacterial lipopolysaccharide, 3998

Lipoprotein see also Apolipoprotein Cholesterol biosynthesis in HeLa S3G cells regulated by serum


Decreased microviscosity of membrane lipids in leukemic cells: Two possible mechanisms, 2306

Escherichia coli mutant with amino acid alteration within signal sequence of outer membrane prolipoprotein, 4891



Lipoprotein-X: Secretion by perfused livers of rats with cholestasis, 3459 Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127 Lipoprotein, high density

Formation of high density lipoprotein2-like particles during lipolysis of very low density lipoproteins in vitro, 4519

Trypanocidal factor identified in normal human serum: High density lipoprotein, 3450

Lipoprotein lipase see Diacylglycerol lipase

Lipoprotein, low density Cholesteryl ester formation in human fibroblasts inhibited by analogue

of 7-ketocholesterol and by progesterone, 1877 Oxygen-mediated heterogeneity of apo-low-density lipoprotein, 3173 Receptor-mediated uptake of low density lipoprotein reconsitituted with


Subject Index 6383



Lipoprotein, very low density Formation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519 Liposome

see also Membrane vesicle Anesthetics and pressure: Effect on thermotropic behavior of

multilamellar dipalmitoylphosphatidylcholine liposomes, 4906 Antigenic phospholipids introduced into plasma membrane of


HLA antigen-containing liposomes: Binding to bacteria, 6197 Preparation of liposomes with large internal aqueous space and high

capture by reverse-phase evaporation, 4194 Reconstitution of purified detergent-soluble HLA-A and HLA-B

antigens into phospholipid vesicles, 3230 Secondary cytotoxic T lymphocytes induced by purified HLA-A and

HLA-B antigens reconstituted into phospholipid vesicles, 5688 Sodium-stimulated active transport of aminoisobutyric acid by

reconstituted vesicles from partially purified plasma membranes of mouse fibroblasts transformed by simian virus 40, 3856

Therapy of leishmaniasis: Superior efficacies of liposome-encapsulated drugs, 2959

Translocation of hydrocarbon fluorescent probe between Epstein-Barr virus and lymphoid cells: Assay for early events in viral infection, 5076

Transmitter release: Changes induced by ion-containing liposomes, 5214 fl-Lipotropin

see also f-Endorphin Bacterial plasmids constructed that contain nucleotide sequence for

bovine corticotropin-f-lipotropin precursor, 6021 Coordinate control of corticotropin, ,B-lipotropin, and ,B-endorphin

release in mouse pituitary cell cultures, 4972 Corticotropin, lipotropin, and ,B-endorphin production by a human

nonpituitary tumor in culture: Evidence for common precursor, 5160 /-Endorphin: Biosynthesis from f-lipotropin and a larger molecular

weight precursor in rat pars intermedia, 4719 f-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant 1-endorphin, 2950 l-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /-endorphin (correction), 5244 /1-Lipotropin, y-lipotropin, and f-endorphin in rat pars intermedia: In

vitro biosynthesis and chemical characterization, 3153 y..Lipotropin

[-Lipotropin, y-lipotropin, and /-endorphin in rat pars intermedia: In vitro biosynthesis and chemical characterization, 3153

Lipoxygenase lonophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Lipoxygenase (EC 1.13.11.12)


Liquid Brilliant total reflection from a liquid-liquid interface, 5772

Lithium [Met5]Enkephalin content in brain regions of rats treated with lithium,

2991 Litorin

Bombesin and litorin interact with specific membrane receptors on pancreatic acinar cells, 6139

Liver see also Membrane, rat liver Albumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879 Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339 Changes in hepatic messenger RNA for phosphoenolpyruvate

carboxykinase (GTP) during development, 4189 Colchicine inhibits changes in amino acid transport and initiation of

DNA synthesis in regenerating rat liver, 1394 Cyclic nucleotide-binding proteins detected by photoaffinity labeling in

nucleus and cytoplasm of bovine liver, 5286 Enrichment of special Novikoff hepatoma and regenerating liver mRNA

by hybridization to cDNA-cellulose, 1736 Enzyme from rat liver that cleaves an ADP-ribosyl histone linkage, 2254 Erythroid colony formation from human fetal liver, 984 H-1 histone in rat liver nuclei: Displacement and aberrant methylation

in vitro after half-saturation of chromatin with polycations, 5773 Ligandin retains and albumin loses bilirubin binding capacity in liver

cytosol, 1213 Methylglyoxal: Isolation from liver, 4317 Principal aflatoxin B1-DNA adduct formed in viuo in rat liver:

Identification, 1745 RNA transport from isolated rat liver nuclei: Activation energy, 5400 Thyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369 Locality principle

Locality principle in wave mechanics, 5270 Longevity

Immunologic function and renal disease in (NZB X NZW)F1 mice: Influence of dietary restriction, 1500

Nutritional inhibition of genetically determined renal disease and autoimmunity with prolongation of life in kdkd mice, 2888

LSD see Lysergic acid diethylamide



6384 Subject Index

Lucibufagin Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905 Luciferase


Luliberin Dense plexus of substance P immunoreactive nerve terminals in

eminentia medialis of primate hypothalamus, 1013 Luminescence

see also Bioluminescence; Chemiluminescence Electric double layer dynamics by high-field electroltuminescence in

aqueous solution (Destriau effect), 2549 Luminophore


Luminosity Kinematics of faint white dwarfs, 4640

Lung see also Alveolus; Cell, lung Pulmonary indoleamine 2,3-dioxygenase: Induction by intraperitoneal

injection of bacterial lipopolysaccharide, 3998 Volume- and time-dependence of alveolar surface tension in excised

lungs: Direct determination, 3417 Luteinizing hormone

see Lutropin Luteinizing hormone-releasing hormone

see Luliberin Lutropin



Ovarian ornithine decarboxylase regulation in immature, pubescent, and pseudopregnant rat, 2530

Rat oocyte maturation in vitro: Relief of cyclic AMP inhibition by gonadotropins, 4369

Lyapounov variable Nonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 1627 Lycopersicon esculentum


Lymphoblast Depurinated DNA repaired in vitro by enzymes purified from human

lymphoblasts, 794 Lymphocyte

see also Cell, B; Cell, lymphocytic; Cell, T; Membrane, lymphocyte Actin may be present on lymphocyte surface, 4484 Adenosine kinase initiates major route of ribavirin activation in cultured

human cell line, 3042 Calcitonin and calcium ionophores: Cyclic AMP responses in cells of a

human lymphoid line, 3984 Loss of human supressor cells during active autoimmune disease, 5150 Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A

methylation reaction essential to cytolysis, 6220 Muscarinic cholinergic receptors in murine lymphocytes: Demonstration

by direct binding, 2902 "Panning" for lymphocytes: Method for cell selection, 2844 Phosphorylation in vivo and in vitro of human histocompatibility


RNA content in human lymphocyte subpopulations, 1938 Suppressor cell activity altered in chronic active hepatitis, 1549 Susceptibility to mitogens retained after direct dansylation of viable

human lymphocytes, 3766 Transglutaminase activity in human lymphocytes: Early activation by

phytomitogens, 1157 Lymphocytic choriomeningitis virus

Anti-interferon globulin inhibits development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus, 3413

Lymphoma see also Cell, lymphoma

Lymphoma, Burkitt Herpesvirus-specific DNA polymerase isolated from tissues of an

American patient with Burkitt lymphoma, 4504 Lysergic acid diethylamide


Lysine see also Poly(L-lysine) Aminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088 Internal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548 Lysine, methyl-

H-1 histone in rat liver nuclei: Displacement and aberrant methylation in vitro after half-saturation of chromatin with polycations, 5773

Lysine, 2-oxoglutarate dioxygenase (EC 1.114.11.4) Lysyl oxidase: Biochemical and immunochemical study in experimental

hepatic fibrosis in rat, 2945 Lysosome

see also Enzyme, lysosomal Attack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825 Cytochemical studies on GERL, provacuoles, and vacuoles in root

meristematic cells of Euphorbia, 852


Endoplasmic reticulum and autophagy in rat hepatocytes, 5039 Epidermal growth factor: Morphological demonstration of binding,

internalization, and lysosomal association in human fibroblasts, 5025 Fluorescence probe measurement of intralysosomal pH in living cells and

perturbation of pH by various agents, 3327 Rat liver microsomal and lysosomal g-glucuronidases differ in both

carbohydrate and amino acid compositions, 3080 Receptor-mediated uptake of low density lipoprotein reconsitituted with


Sanfilippo syndrome type C: Deficiency of acetyl-CoA:n-glucosaminide N-acetyltransferase in skin fibroblasts, 5185

Lysozyme Enzyme catalysis: Energetics, 5250 Method to assess similarity of protein structures, with applications to T4

bacteriophage lysozyme, 2180 Regulation of transcription of late genes of bacteriophage T7, 804

Lysyl oxidase see Lysine,2-oxoglutarate dioxygenase

Lytechinus pictus Hatching in sea urchin Lytechinus pictus is accompanied by shift in

histone H4 gene activity, 4135

Macdonald identity Lie algebras and classical partition identities, 578

a2-Macroglobulin Ultrastructural antibody localization (f (v2-macroglobulin in

membrane-limited vesicles in cultured cells, 4359 Macromolecule

Macromolecular shape and surface maps by solvent exclusion, 303 Polycationic macromolecules inhibit cilia-mediated ovum transport in

rabbit oviduct, 4413 Statistics of self-avoiding walks confined to strips and capillaries, 2069

Macromolecule, encapsulated Preparation of liposomes with large internal aqueous space and high

capture by reverse-phase evaporation, 4194 Macrophage

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: Possible mechanism of inflammatory demyelination, 1554





Tuftsin (an Ig-associated tetrapeptide) triggers immunogenic function of macrophages: Implications for activation of programmed cells, 3400

Magnesium Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379 Spermine and magnesium ion binding to yeast phenylalanine transfer

RNA: Structural analysis, 64 Magnetic structure

Rotational symmetry: Effect on colored lattices, 5751 Magnetic susceptibility

Laccase and oxyhemocyanin: Magnetic susceptibility studies, 3019 Oxy- and carbonmonoxyhemoglobin: Room-temperature magnetic

properties, 4916 Maize

see Zea mays Major histocompatibility complex

see also Antigen, histocompatibility; Histocompatibility Biological significance of alloreactivity: T cells stimulated by Sendai

virus-coated syngeneic cells specifically lyse allogeneic target cells, 5145

Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly(Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion, 2387

Lymphoid dendritic cells are potent stimulators of primary mixed leukocyte reaction in mice, 5132



Murine Ss protein: Ss protein is functionally the fourth component of complement, 2424

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes, 441



Stage-specific polypeptides synthesized during murine preimplantation development: Identification, 3332

Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes, 970

Malaria Erythrocytic mechanlism of sickle cell resistance to malaria, 1994 Immunization against malaria with antigen from Plasmodium

falciparum cultivated in vitro, 5665




Malaria merozoites isolated: Release of Plasmodium chabaudi merozoites from schizonts bound to immobilized concanavalin A, 5081


Malnutrition see also Diet; Nutrition; Starvation Diet, genetics, and mental retardation interaction between


Mammary gland Hormonal induction of secretory immune system in mammary gland,

2928 (y-Lactalbumin mRNA in 4-day lactating rat mammary gland, 4739 Lactose and major milk proteins are present in secretory vesicle-rich

fractions from lactating mammary gland, 5020 Mammary tissue

Differences in isoelectric focusing patterns of y-glutamyl transpeptidase from normal and cancerous rat nmammary tissue, 1750

Manduca sexta Specificity of juvenile hormone binding protein: Geometrical isomers of

juvenile hormone I, 185 Manganese

Bond angles in transition metal tetracarbonyl compounds: Test of theory of hybrid bond orbitals, 569

Bond angles in transition-metal tricarbonyl compounds: Test of the theory of hybrid bond orbitals, 12


Mania [Met5lEnkephalin content in brain regions of rats treated with lithium,

2991 Mannose


Mantle convection Global problems of geophysical fluid dynamics (Review), 34

Marmota monax Virus similar to human hepatitis B virus associated with hepatitis and

hepatoma in woodchucks, 4533 Martingale transform

Limit theorems for weighted sums and stochastic approximation processes, 1068

Mass spectrometry Four trans-3,4-dihydrodiol metabolites of

7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism, 5466

Partitioning of bound inorganic phosphate during medium and intermediate phosphate-water oxygen exchange reactions of yeast inorganic pyrophosphatase, 3133

Mass spectroscopy Lipid A and endotoxin in serum determined by mass spectroscopy, 3993

Maternal inheritance EcoRI cleavage site variants of mitochondrial DNA molecules from rats,

909 Mating factor a

Mating factor (C: Inactivation and chemical alteration by cells and .spheroplasts of yeast, 1304

Mating system, Mendelian Generalizing Fisher's "reproductive value": "Incipient" and

"penultimate" reproductive-value functions when environment limits growth; linear approximants for nonlinear Mendelian mating models, 6327

Matrix vesicle Calcification of isolated matrix vesicles and reconstituted vesicles from

fetal bovine cartilage, 3805 Maxwell construction

Maxwell-type constructions for multiple nonequilibrium steady states, 3023

Mayer-Vietoris sequence Second Leray spectral sequence of relative hypercohomology, 4666

Mayfly see Ephemerella dorothea

Measure theory Some new singular Fourier-Stieltjes series, 5268

Meiosis Protein synthesis: Absolute rates during meiotic maturation of

mammalian oocytes in vitro, 4160 Rat oocyte maturation in vitro: Relief of cyclic AMP inhibition by

gonadotropins, 4369 Time of recombination in Drosophila melanogaster oocyte: Evidence

from a temperature-sensitive recombination-deficient mutant, 3351 Xenopus laevis oocytes: Induction of maturation by a steroid linked to a

polymer, 2353 a-Melanocyte stimulating hormone

see a-Melanotropin Melanoma


Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is independent of amount of bromouracil in DNA, 4982

Ia-like antigens: Expression on cultured human malignant melanoma cell lines, 6235

a-Melanotropin a-Melanocyte stimulating hormone: Immunohistochemical identification

and mapping in neurons of rat brain, 6300 Melatonin


Subject Index 6385

Melphalan Tumor cells: Time-dependent resistance or susceptibility to cytotoxic

antibody after exposure to chemotherapeutic agent, 6202 Membrane

see also Escherichia coli membrane Complement lesion: Molecular nature, 5655 Deuterium nuclear magnetic resonance investigation of effects of

proteins and polypeptides on hydrocarbon chain order in model membrane systems, 4657

Geometric packing constraints in egg phosphatidylcholine vesicles, 308 Ion flow through a membrane: Concentration and current responses to a

step potential change, 1612 Ion flow through a membrane: Effect of chemical reaction on time

dependence, 2064 Molecular mechanisms for proton transport in membranes, 298 Molecular motion in membranes determined using periodic pattern

photobleaching, 2759 Photochemical technique for measuring lateral diffusion of spin-labeled

phospholipids in membranes, 4661 Protein-lipid interactions in bilayer membranes: Theoretical study, 1616 Spatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313 Tracer exchange across C5b-9 complement lesion in a biological

membrane: Steady-state analysis, 5669 Membrane, bacterial

Bacteriorhodopsin: Molecular orientation within the purple membrane of Halobacterium halobium, 4320

Cell surface of Micrococcus radiodurans: Topographic study, 5525 Escherichia coli mutant with amino acid alteration within signal

sequence of outer membrane prolipoprotein, 4891 Membrane lateral phase separations and chlortetracycline transport by

Bacillus megaterium, 1319 Membrane moiety of the H+-ATPase complex resolved into two kinds of

subunits, 4219 Nascent peptide as sole attachment of polysomes to membranes in

bacteria, 814 Secondary protein-chromophore interactions at Schiff base linkage in

bacteriorhodopsin: Molecular mechanism for proton pumping, 4642 Secreted nascent chains: Interaction with surrounding membrane in

Bacillus subtilis, 5922 Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127 Membrane biogenesis

Asymmetric budding of viruses in epithelial monolayers: Model system for study of epithelial polarity, 5071

Membrane, biological Cardiolipin: Stereospecifically spin-labeled analogue and its specific

enzymic hydrolysis, 1227 Membrane, brain

Bombesin: Specific binding to rat brain membranes, 5372 Histamine H1 receptors identified in mammalian brain membranes with

[3H]mepyramine, 6290 Interaction of ligands with opiate receptors of brain membranes:

Regulation by ions and nucleotides, 1713 Membrane-bound neuraminidase from calf brain: Regulation of



Membrane, brush border High-affinity folate binding activity associated with brush border

membranes of rat kidney, 3090 Membrane depolarization

Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic monophosphate levels in neuroblastoma cells, 6295

Membrane, electroplax Acetylcholine-receptor-mediated ion flux in electroplax membrane



Membrane, erythrocyte Adenylate cyclase activation through the /3-adrenergic receptor:

Catecholamine-induced displacement of bound GDP by GTP, 4155 Agonist-induced increase in apparent f-adrenergic receptor size, 228 Anti-spectrin antibody and ATP affect deformability of resealed

erythrocyte membranes, 3823 Cholera toxin action: Covalent modification of guanyl nucleotide-binding

protein of adenylate cyclase system, 2669 Electron spin resonance studies on interaction of complement proteins

with erythrocyte membranes, 4930 Erythrocyte membrane abnormalities in Duchenne muscular dystrophy

monitored by saturation transfer electron paramagnetic resonance spectroscopy, 838

Phosphatidylcholine: Enzymatic synthesis and rapid translocation by two methyltransferases in erythrocyte membranes, 2348

Structural polymorphism within amino-terminal region of MM, NN, and MN glycoproteins (glycophorins) of human erythrocyte membrane, 2727


Membrane, excitable Receptor-controlled tracer efflux from sealed membrane fragments:

Kinetic analysis, 3756



6386 Subject Index

Membrane, fat cell Insulin binding to solubilized material from fat cell membranes:

Evidence for two binding species, 2593 Membrane fluidity


Evolutionary adaptation of membranes to temperature, 2040 Role of contact inhibition in regulation of receptor-mediated uptake of

low density lipoprotein in cultured vascular endothelial cells, 356 Membrane glycoprotein


Membrane, heart Presynaptic and postsynaptic ((-adrenoceptors in rat heart membranes:

Positive homotropic cooperativity of presynaptic binding, 6285 Membrane hyperpolarization

Cyclic GMP injected into retinal rod outer segments increases latency and amplitude of response to illumination, 5218

Membrane lipid Decreased microviscosity of membrane lipids in leukemic cells: Two

possible mechanisms, 2306 Macrophage tumoricidal capability modulated by polyene antibiotics:

Support for membrane lipid as a regulatory determinant of macrophage function, 4349

Specific antibody-dependent binding of complement component Clq to hapten-sensitized lipid vesicles, 1515

Membrane, lymphocyte Translocation of hydrocarbon fluorescent probe between Epstein-Barr

virus and lymphoid cells: Assay for early events in viral infection, 5076 Membrane, mammalian

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator", 5432

Membrane, mitochondrial Alternative membrane transport pathway for phosphate and adenine

nucleotides in mitochondria and its possible function, 4788 Low molecular weight Ca2+ carrier isolated from calf' heart inner

mitochondrial membrane, 2125 Membrane particle aggregate


Membrane permeability Calcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertensive rat, 1605 Membrane, plasma

Antigenic phospholipids introduced into plasma membrane of mammalian cells: Organization and antibody-induced lipid redistribution, 5529

Cholera toxin-activated adenylate cyclase: Reconstitution, 3113 Decreased microviscosity of membrane lipids in leukemic cells: Two

possible mechanisms, 2306 Defective regulation of cholesterol biosynthesis and plasma membrane

fluidity in Chinese hamster ovary cell mutant, 1247 Different regulation of insulin receptors in intracellular (Golgi) and

plasma membranes from livers of obese and lean mice, 3302 Fluorescent labeling of hormone receptors in viable cells: Preparation


Growth of 3T3 cells inhibited by extract of surface membranes, 5457 Lateral diffusion coefficients of hormone-receptor complexes of insulin




Subcellular fractionation of intra-axonally transported polypeptides in rabbit visual system, 505

Susceptibility to mitogens retained after direct dansylation of viable human lymphocytes, 3766

Xenopus laevis oocytes: Induction of maturation by a steroid linked to a polymer, 2353

Membrane potential Catecholamine transport into chromaffin vesicles is coupled to vesicle

membrane potential, 5190 Changes in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818 Colicin Ia: Effect on Escherichia coli proton electrochemical gradient,

2579 Interneuron involved in generation of slow inhibitory postsynaptic

potential in mammalian sympathetic ganglia, 4029 Reduction of membrane potential, an immediate effect of colicin K, 2483 Transmembrane ion gradients: Effect on Raman spectra of sealed,

hemoglobin-free erythrocyte membrane vesicles, 5478 Membrane protein



Diamagnetic anisotropy and orientation of a helix in frog rhodopsin and meta II intermediate, 5471


Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus, 3846




Linear arrays of intramembranous particles in pulmonary tubular myelin, 6225




Mutations altering cellular localization of phage X receptor, an Escherichia coli outer membrane protein, 5802

Phosphorylation in vivo and in vitro of human histocompatibility antigens (HLA-A and HLA-B) in carboxy-terminal intracellular domain, 6002

Protein micelles formed from amphiphilic membrane proteins, 5306 Proteins conferred by the virulence-specifying plasmid of Agrobacterium

tumefaciens C-58, 3796 Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955 Reconstitution of purified detergent-soluble HLA-A and HLA-B

antigens into phospholipid vesicles, 3230 Synthesis of phage M13 coat protein and its assembly into membranes in

vitro, 1754 Membrane, rat liver



Membrane structure Sterol requirement of Mycoplasma capricolum, 4107

Membrane, synaptic Endogenous protein inhibitor of high affinity binding of -y-aminobutyric

acid to synaptic membranes of rat brain: Purification, 4024 Ontogeny of synaptic phosphoproteins in brain, 4037

Membrane, testis Human chorionic gonadotropin: Interaction with membrane components

of rat testes, 764 Membrane, thyroid


Membrane, Torpedo marmorata Distinct protein components from Torpedo marmorata membranes carry


Membrane vesicle see also Liposome Acetylcholine receptor localized in excitable membrane from electric



Fluorescence energy transfer in the rapid-diffusion limit, 5746 Functional lac carrier protein in cytoplasmic membrane vesicles isolated

from Escherichia coli: Temperature and pH dependence of dansyl-galactoside binding, 4214

Membrane vesicles from Escherichia coli: Molecular structure, 3148 Role of Na+ in a-aminoisobutyric acid uptake by membrane vesicles

from mouse fibroblasts transformed by simian virus 40, 2329 Sodium-dependent amino acid transport by cultured hamster cells:

Membrane vesicles retain transport changes due to glucose starvation and cycloheximide, 5048

Ultrastructural antibody localization of a2-macroglobulin in membrane-limited vesicles in cultured cells, 4359

Membrane vesicle, plant ATP-dependent Ca2+ uptake into plant membrane vesicles, 1232

Membrane viscosity Alterations of hepatic Na+,K+-ATPase and bile flow by estrogen: Effects

on liver surface membrane lipid structure and function, 4130 Memory

Conditioned behavior of rats modified by neurohypophyseal hormones and analogues, 2493

Menadione reductase see NAD(P)H dehydrogenase (quinone)

Mengo virus Translation of animal virus RNA in cytoplasm of plant cell, 5557

Meningitis Haemophilus influenzae bacteremia and meningitis resulting from

survival of a single organism, 1.534 Mental retardation

Diet, genetics, and mental retardation interaction between phenylketonuric heterozygous mother and fetus to produce nonspecific diminution of IQ: Support of justification hypothesis, 1562

Inbreeding: Effect on IQ and mental retardation, 3906 Mepyramine


2-Mercaptoethanol Production of autoinhibitory factors by mouse lymphoma cells in vitro

and its relationship to thiol dependence, 1849 Meromorphic solution


Meromyosin, heavy Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,

and subfragments of myosin, 54





Mesenchyme Induction de novo of a gene product during heterologous

epithelial-mesenchymal interactions in vitro, 2790 Metabolic regulation

Allosteric regulation of monocyclic interconvertible enzyme cascade systems: Escherichia coli glutamine synthetase as an experimental model, 3138

Metal binding Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181 Metal ion binding site

Topographical analysis of regulatory and metal ion binding sites on glutamine synthetase from Escherichia coli: 13C and 31p nuclear magnetic resonance and fluorescence energy transfer study, 1255

Metalloporphyrin Photosensitivity of liganded hemoproteins and their metal-substituted

analogues, 21 Metalloprotein

see also Protein, copper; Protein, iron-sulfur; specific metals Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase

with Zn2+ as cofactor, 2185 Metaplectic group

Automorphic L-functions of half-integral weight, 1620 Methionine


Protein synthesis: Absolute rates during meiotic maturation of mammalian oocytes in vitro, 4160

Methionine analog Methionine analogs and cell division regulation in Saccharomyces

cerevisiae, 6083 Methionine heptapeptide

Protected homo-oligopeptide structure: Model for preferred conformation of a linear methionine heptapeptide in chloroform, 4647

Methotrexate Amplified dihydrofolate reductase genes are localized to a

homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line, 5553

Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells, 3867



Methylation S-Adenosyl-L-methionine-mediated methylation required for human

monocyte chemotaxis, 3928 Methylcholanthrene

Anltibody response of mice to chemically induced tumors, 955 Methylglyoxal

Electronic properties of some protein-methylglyoxal complexes, 315 Internal charge transfer in proteins to Schiff bases of their lysine side

chains, 3548 Methylglyoxal: Isolation from liver, 4317

Methyl methanesulfonate Depurinated DNA repaired in vitro by enzymes purified from human

lymphoblasts, 794 Methyltransferase


Lymphocyte-mediated cytolysis inhibited by 3-deazaadenosine: A methylation reaction essential to cytolysis, 6220


Methylxanthine Adenosine analogs inhibit adipocyte adenylate cyclase by a


Methylxanthine, 3-isobutyl-1- Monolayer formation in cultured whole pancreatic islets promoted by

3-isobutyl-1-methylxanthine, 1897 Micrococcal nuclease

see Spleen endonuclease Micrococcus luteus

Micrococcus luteus DNA gyrase: Active components and model for its supercoiling of DNA, 2098

Micrococcus radiodurans Cell surface of Micrococcus radiodurans: Topographic study, 5525

Microfilament see also Filament; Neurofilament Assay for early cytoplasmic effects of src gene prodtct of Rous sarcoma

virus, 2750 Biochemistry of actomyosin-dependent cell motility (Review), 588 Calcium-dependent regulator protein: Localization in mitotic apparatus

of eukaryotic cells, 1867 f2-Microglobulin

32-Microglobulin and HLA antigens: Enhanced expression on human lymphoid cells by interferon,'6215

Microtubule Calcium-dependent regulator protein: Localization in mitotic apparatus

of eukaryotic cells, 1867 Colchicine inhibits changes in amino acid transport and initiation of

DNA synthesis in regenerating rat liver, 1394 Combined immunofluorescence and high-voltage electron microscopy of


Subject Index 6387


Differences in (5 and Af polypeptide chains of tubulin resolved by electron microscopy with image reconstruction, 5006

Growth cone formation in cultures of sensory neurons, 5226 Microtubule assembly-disassembly controlled by calcium-dependent

regulator protein, 3771 Mitochondria are associated with microtubules in cultured cells, 3863 Potent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220 Relationship between dibutyryl cyclic AMP and microtubule

organization in contracting heart muscle cells, 319 Role of nucleotides in tubulin polymerization: Effect of guanosine

5'-methylene diphosphonate, 3178 Three-dimensional electron microscopical visualization of cytoskeleton of

animal cells: Immunoferritin identification of actin- and tubulin-containing structures, 5511


Microtus pennsylvanicus Dispersal in relation to carrying capacity, 2854

Microvessel Isolated microvessels: Blood-brain barrier in uitro, 4544

Microviscosity Decreased microviscosity of membrane lipids in leukemic cells: Two

possible mechanisms, 2306 Midbody


Migration Random genetic drift in a cline, 423

Milk Human milk stimulates DNA synthesis and cellular proliferation in

cultured fibroblasts, 5057 Lactose and major milk proteins are present in secretory vesicle-rich

fractions from lactating mammary gland, 5020 Milk precipitin

Milk precipitins, circulating immune complexes, and IgA deficiency, 3387 Mineralization


Minicell Low molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673 Miocene

Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263 Mitochondrion

see also Deoxyribonucleic acid, mitochondrial Alternative membrane transport pathway for phosphate and adenine

nucleotides in mitochondria and its possible function, 4788 Branched chain s-keto acid dehydrogenase complex of bovine kidney:

Purification and characterization, 4881 Complex III of mitochondrial electron transfer chain: Resolution into

two component complexes, 5377 Cytoplasmic inheritance of rutamycin resistance in mouse fibroblasts,

324 Cyt(plasmic transfer of resistance to antimycin A in Chinese hamster

cells, 5604 High-resolution 31P nuclear magnetic resonance study of rat liver

mitochondria, 1796 Low molecular weight Ca2+ carrier isolated from calf heart inner

mitochondrial membrane, 2125 Mitochondria are associated with microtubules in cultured cells, 3863 Mitochondrial DNA from Chlamydomonas reinhardtii: Isolation and

characterization, 3268 .Mitochondrial translation products: Variation associated with

male-sterile cytoplasms in maize, 3841 Regulation of Ca2+ release from mitochondria by oxidation-reduction

state of pyridine nucleotides, 1690 Replication in mitochondrial DNA molecules from Drosophila

melanogaster: Origin and direction, 3886 Stoichiometry of vectorial H+ movements coupled to electron transport

and to ATP synthesis in mitochondria, 5296 Subcellular fractionation of intra-axonally transported polypeptides in

rabbit visual system, 505 Mitogen


S'usceptibility to mitogens retained after direct dansylation of viable human lymphocytes, 3766

Mitosis Calcium-dependent regulator protein: Localization in mitotic apparatus

of eukaryotic cells, 1867 Inducers of DNA synthesis present during mitosis of mammalian cells

lacking Gl and G2 phases, 5043 ]Intercellular bridge from cultured mouse cells: Partial purification and

characterization, 4977 Microtubule assembly-disassembly controlled by calcium-dependent

regulator protein, 3771 Spontaneous mitotic recombination occurs at the two-strand stage, 4436 Tumor promoter induces sister chromatid exchanges: Relevance to

mechanisms of carcinogenesis, 6149 Mitotic drug

I)ifferent intermediate-sized filaments distinguished by immunofluorescence microscopy, 5034

Mocimycin Mutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470



6388 Subject Index

Moduli space Stability of local rings of dimension 2, 4085

Molecular cloning Construction and properties of chimeric plasmids in Bacillus subtilis,

1428 Excision of DNA segments introduced into cloning vectors by

poly(dA-dT) joining method, 1763 Gene adjacent to satellite DNA in Drosophila melanogaster, 5898 Molecular cloning of genetically active fragments of Bacillus DNA in

Bacillus subtilis and properties of vector plasmid pUBlO, 1423 Multiple related immunoglobulin variable-region genes identified by

cloning and sequence analysis, 3881 Ovalbumin gene: Cloning of natural gene, 3688

Molecular field theory Molecular field theory of reversible unf'olding of biopolymers, 2755

Molecular orbital see also Hybrid bond orbital theory Bacteriochlorophyll electronic transition moment directions in

bacteriochlorophyll a-protein, 4920 Cyclopenta[c,d]pyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667 Molecular orientation

Electric double layer dynamics by high-field electroluminescence in aqueous solution (Destriau effect), 2549

Molybdenum phosphite complex Chemistry of low-valent molybdenum phosphite complexes: Models of

seven-coordinate reaction intermediates, 1056 Momordica charantia abbreviata


Monensin Serum stimulates Na+,K+ pump in quiescent fibroblasts by increasing

Na+ entry, 5560 Monocyte

S-Adenosyl-L-methionine-mediated methylation required for human monocyte chemotaxis, 3928


Monophenol monooxygenase (EC 1.14.18.1) Laccase and oxyhemocyanin: Magnetic susceptibility studies, 3019 Reductant-dependent electron distribution among redox sites of laccase,

5245 Tyrosinase from Neurospora crassa: Amino acid sequence, 3635

Monte Carlo method Interacting enzyme systems at steady state: Further Monte Carlo

calculations on two-state molecules, 5260 Protein folding: Respective roles of short- and long-range interactions,

559 Monte Carlo study

Statistics of self-avoiding walks confined to strips and capillaries, 2069 Morphine

see also Apomorphine Inhibition by Z-Pro-D-Leu of development of tolerance to and physical

dependence on morphine in mice, 4573 Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,

1546 Morphogenesis

Determination of capsid size by satellite bacteriophage P4, 400 Mouse


Immunologic function and renal disease in (NZB X NZW)F1 mice: Influence of dietary restriction, 1500

Location on chromosome 1 of Rnr, a gene that regulates renin in submaxillary gland of mouse, 5623

Nutritional inhibition of genetically determined renal disease and autoimmunity with prolongation of life in kdkd mice, 2888

Preadipocyte clonal line established from epididymal fat pad of ob/ob mouse that responds to insulin and to lipolytic hormones, 6054


Teratocarcinoma cell variants rejected by syngeneic mice: Protection of mice immunized with these variants against other variants and against the original malignant cell line, 1519

Mucopolysaccharidosis Sanfilippo syndrome type C: Deficiency of acetyl-CoA:(Y-glucosaminide

N-acetyltransferase in skin fibroblasts, 5185 Multienzyme complex


Multiple sclerosis Multiple sclerosis cerebrospinal fluid: Components detected by

radioimmunoassay for myelin basic protein, 1976 Muon pair

Failure of Drell-Yan parton model to account for production of J/'T in nucleon-nucleon interactions, 5770

Muramyl dipeptide Immunization against malaria with antigen from Plasmodium

falciparum cultivated in vitro, 5665 Neonate's nonspecific immunity to Klebsiella infection enhanced by

muramyl dipeptide, a synthetic immunoadjuvant, 3395 Murein

Cellular division in Escherichia coli: Series of mutants of E. coli altered in penicillin-binding proteins, 664

Muscimol -y-Aminobutyric acid receptors: Autoradiographic localization in rat

central nervous system by using [3H]muscimol, 1024


-y-Aminobutyric acid receptors: Quantitative visualization in hippocampus and area dentata demonstrated by [3H]muscimol autoradiography, 2516

Y-Aminobutyric acid receptors: Ultrastructural localization in mammalian central nervous system by means of [3H]muscimol binding, 2977


Muscle see also Cell, muscle Calcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertetnsive rat, 1605 Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329 Contraction of detergent-treated smooth muscle, 3527 Differential effects of perhydrohistrionicotoxin on neurally and

iontophoretically evoked endplate currents, 1596 Immunization of rats with polypeptide chains from torpedo acetylcholine

receptor causes autoimmune response to receptors in rat muscle, 769 Major serine protease in rat skeletal muscle: Its mast cell origin, 5311 Monovalent antibodies against MM-creatine kinase remove M line from

myofibrils, 4296 Myasthenic patients' immunoglobulin affects acetylcholine receptor

turnover: Selectivity of degradation process, 3422 Relationship between dibutyryl cyclic AMP and microtubule

organization in contracting heart muscle cells, 319 Specific phosphorylation at serine-283 of ( tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588 Thyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369 Muscle fiber, glycerinated


Muscular dystrophy Erythrocyte membrane abnormalities in Duchenne muscular dystrophy

monitored by saturation transfer electron paramagnetic resonance spectroscopy, 838

Mustelus canis Attack of sea urchin eggs by dogfish phagocytes: Model of

phagocyte-mediated cellular cytotoxicity, 1825 Mutagenesis

Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is independent of amount of bromouracil in DNA, 4982


Cyclopenta[c,d]pyrene: A highly mutagenic polycyclic aromatic hydrocarbon, 1667


Escherichia coli plasmid bearing functional gene G of bacteriophage kX174: Construction and characterization, 774


Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons, 2003

Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens, 2864


Local mutagenesis: Method for generating viral mutants with base substitutions in preselected regions of viral genome (correction), 4596



Mutagenesis during in vitro DNA synthesis, 1924 Mutagenesis of a circular DNA molecule in vitro by using synthetic

restriction sites, 6012 Nucleosome rearrangement in human chromatin during UV-induced

DNA repair synthesis, 4238 06-Methylguanine: Repair in adapted Escherichia coli, 6017 Ouabain-resistant mutations induced in C3H 1OTI/2 mouse cells by

ultraviolet light, 3363 Quantitative forward mutation assay in Salmonella typhimurium using


Salmonella typhimurium, 4465 Temperature-sensitive mutants in Tetrahymena: Mass isolation and

fertility testing, 3355 Temperature-sensitive mutants of mouse hepatitis virus produce a high

incidence of demyelination, 4033 Mutant, deletion

Viable deletion mutants in simian virus 40 early region, 4455 Mutant screening


Mutant, temperature-sensitive Drosophila mutant with a temperature-sensitive block in nerve

conduction, 4047 Expression of simian virus 40 early genes in transformed rat cells is

correlated with maintenance of transformed phenotype, 4987 Ornithine decarboxylase activity: Induction in a temperature-sensitive

cell cycle mutant of Chinese hamster cells, 5001 Plasmid-encoded protein required for replication in vitro of plasmid

R6K, 5381 Reversion of transformed glycolysis to normal by inhibition of protein






Simian virus 40 A gene function: DNA content analysis of Chinese hamster cells transformed by early temperature-sensitive virus mutant, 4389

Temperature-sensitive Escherichia coli mutant producing a temperature-sensitive a subunit of DNA-dependent RNA polymerase, 6177

Temperature-sensitive mutants in Tetrahymena: Mass isolation and fertility testing, 3355

Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence-of demyelination, 4033

Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro, 4291


Template requirements of N4 virion RNA polymerase, 3220 Time of recombination in Drosophila melanogaster oocyte: Evidence

from a temperature-sensitive recombination-deficient mutant, 3351 Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted

lysis of infected cells by cytotoxic T lymphocytes, 970 Mutation

Naturally occurring promoter down mutation: Nucleotide sequence of trp promoter/operator/leader region of Shigella dysenteriae 16, 5580

Potassium transport in L cells: Genetic alterations, 5589 Stepwise mutation model and distribution of allelic frequencies in a

finite population, 2868 Mutation assay

Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker, 410

Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium, 4465

Mutation, correction of Efficient correction of a mutation by use of chemically synthesized DNA,

4268 Mutation rate

Estimation of expected number of rare alleles of a locus and calculation of mutation rate, 5094

Mutation, somatic Model for incidence of embryonal cancers: Application to

retinoblastoma, 2453 Somatic mutation and neoplastic transformation, 3297

Myasthenia gravis Immunization of rats with polypeptide chains from torpedo acetylcholine

receptor causes autoimmune response to receptors in rat muscle, 769 Myasthenic patients' immunoglobulin affects acetylcholine receptor

turnover: Selectivity of degradation process, 3422 Specific immunosuppression of experimental autoimmune myasthenia

gravis by denatured acetylcholine receptor, 4006 Mycobacterium smegmatis


Mycoplasma capricolum Sterol requirement of Mycoplasma capricolum, 4107

Mycoplasma hyorhinis Selective association of murine T lymphoblastoid cell surface

alloantigens with Mycoplasma hyorhinis, 4479 Myelin

see also Protein, myelin basic Degradation of basic protein in myelinl by neutral proteases secreted by

stimulated macrophages: Possible mechanism of inflammatory demyelination, 1554

Linear arrays of intramembranous particles in pulmonary tubular myelin, 6225

Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation, 2521

Myeloma Myeloma variants with predefined variant surface immunoglobulin

isolated by cell sorting, 3901 Organization of immunoglobulin heavy chain genes and allelic deletion

model, 2140 Units of transcription for cytoplasmic RNA in mouse myeloma cells,

4374 Myoblast

Clusters of intramembranous particles on cultured myotubes at sites that are highly sensitive to acetylcholine, 3004

Myoblast phenotype altered by dimethyl sulfoxide, 3826 Myofibril



Myoglobin see also Oxymyoglobin Cooperativity in 02 binding to iron porphyrins, 1052 Heme disorder in hemoproteins: Proton nuclear magnetic resonance

characterization, 5755 Model compounds for T state of hemoglobin, 564 Stochastic theory of ligand migration in biomolecules, 26

Myosin see also Meromyosin, heavy; Tropomyosin Biochemistry of actomyosin-dependent cell motility (Review), 588 Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,

and subfragments of myosin, 54 Interaction between actomyosin and 8-substituted ATP analogs, 4229 Potent inhibition of dynein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220

Subject Index 6389

Myotube Channel open time and metabolic stability of synaptic and extrasynaptic

acetylcholine receptors on cultured chick myotubes, 520 Clusters of intramembranous particles on cultured myotubes at sites that

are highly sensitive to acetylcholine, 3004 DNA synthesis induced in terminally differentiated myotubes by

activation of src gene of Rous sarcoma virus, 5501 Myristic acid



NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2) Azo dyes prevent hydrocarbon-induced leukemia in rat, 4524

Nafoxidine Estrogen receptor binding and transcriptional activity: Role in

stimulation of hyperestrogenism and nuclear bodies, 2781 Nalidixic acid

Phage Mu-I integration: Nalidixic acid treatment causes clustering of Mu-1-induced mutations near replication origin, 4940

Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity, 1773

:Naloxone Endorphins may function in heat adaptation, 2923 Endorphins may function in heat adaptation (correction), 4596 Systemic administration of #-endorphin: Potent hypotensive effect

involving a serotonergic pathway, 6240 National Academy of Sciences USA

National Academy of Sciences USA: Classes, council, members, officers, sections, 4598

Natural killing Natural killing and antibody-dependent cellular cytotoxicity are

independent immune functions in Minnesota miniature swine, 5127 Natural selection

Change of gene frequencies by natural selection under population number regulation, 1934

Nebula Chemical composition of gaseous nebula NGC 6302, 1

Nematode see Ascaris lumbricoides

Neocarzinostatin Nucleotide specificity in DNA scission by neocarzinostatin, 3603 Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608 Neonate


Spin assay for reserve bilirubin loading capacity of human serum, 1542 Neoplasia

Neoplastic transformation in vitro: Progressive nature, 3761 Neovascularization


Nephronophthisis Nutritional inhibition of genetically determined renal disease and

autoimmunity with prolongation of life in kdkd mice, 2888 Nerve

see also Auditory nerve fiber; Axon; Ganglion; Neuron; specific cells Nerve conduction


Nerve terminal Cholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324 Dense plexus of substance P immunoreactive nerve terminals in

eminentia medialis of primate hypothalamus, 1013 Nervous system

Evolution of the nervous system: Role of ontogenetic mechanisms in evolution of matching populations, 1349


Presynaptic and postsynaptic a-adrenoceptors in rat heart membranes: Positive homotropic cooperativity of presynaptic binding, 6285

NIervous system, autonomic Adrenergic differentiation of cells of cholinergic ciliary and Remak

ganglia in avian embryo after in vivo transplantation, 2030 Nervous system, central

-y-Aminobutyric acid receptors: Autoradiographic localization in rat central nervous system by using [3H]muscimol, 1024

y-Aminobutyric acid receptors: Ultrastructural localization in mammalian central nervous system by means of [3H]muscimol binding, 2977


Isolated microvessels: Blood-brain barrier in vitro, 4544 Neonatal suprachiasmatic nucleus ablation: Absence of functional and

morphological plasticity, 6243 Nerve growth factor: Intraventricular administration induces ornithine

decarboxylase in peripheral tissues of rat, 2512 Neurocytotoxic antibodies in serum of patients with systemic lupus

erythematosus, 3965 Serotonin and substance P coexist in neurons of rat's central nervous

system, 1582 Nervous system, sympathetic

Nerve growth factor-mediated induction of tyrosine hydroxylase in clonal pheochromocytoma cell line, 4587



6390 Subject Index

Netropsin Distamycin-DNA and netropsin-DNA complexes: Conformational

features by Raman spectroscopy, 5483 Neural crest


Neuraminidase (EC 3.2.1.18) Complement C3 convertase: Cell stirface restriction of /1H control and

generation of restriction on neuraminidase-treated cells, 2416 Differences in isoelectric focusing patterns of --glutamyl transpeptidase

from normal and cancerous rat mammary tissue, 1750 Membrane-bound neuraminidase from calf brain: Regulation of



Neurite Growth cone formation in cultures of sensory neurons, 5226 Nerve growth factor-induced fiber outgrowth from isolated rat adrenal

chromaffin cells: Impairment by glucocorticoids, 3498 Neurite outgrowth induced by a conditioned-medium factor bound to

culture substratum, 5210 Neurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200 RNA synthesis-dependent and -independent pathways in stimulation of

neurite outgrowth by nerve growth factor, 6059 Neurobiology


Neuroblastoma Neurocytotoxic antibodies in serum of patients with systemic lupus

erythematosus, 3965 Neuroendocrine

Neuronal interaction mediated by behaviorally active peptide, 5732 Neuroethology

Steering responses of flying crickets to sound and ultrasound: Mate attraction and predator avoidance, 4052

Neurofilament Differences among 100-A filament subunits from different cell types,

4364 Neurogenesis

Olfactory axons and synapse formation regenerated in forebrain after bulbectomy in neonatal mice, 5230

Neurohypophyseal hormone Conditioned behavior of rats modified by neurohypophyseal hormones

and analogues, 2493 Neuroleptic

a-Adrenergic receptors in caudate nucleus selectively labeled by [3H]dihydroergocryptine in presence of spiperone-blocked dopamine receptors, 2249

Neuromuscular blocker Physicochemical properties of triphosphoinositide altered by nicotinic

ligands, 784 Neuromuscular junction

Genetic dissection of short-term and long-term facilitation at Drosophila neuromuscular junction, 515

Neuromuscular transmission blocked by enzymatically active and inactive /-bungarotoxin, 1029

Transmitter release: Changes induced by ion-containing liposomes, 5214 Neuron

see also Nerve Acetylcholine release from neuroblastoma X glioma hybrid cells:

Regulation, 1314 Adrenergic differentiation of cells of cholinergic ciliary and Remak

ganglia in avian embryo after in vivo transplantation, 2030 Cholera toxin: Endocytosis into neuronal GERL, 2815 Electrotonic synapses uncoupled by calcium, 4577 Factor from neurons increases the number of acetylcholine receptor

aggregates on cultured muscle cells, 4011 (-Melanocyte stimulating hormone: Immunohistochemical identification

and mapping in neurons of rat brain, 6300 Motoneurons of the nematode Ascaris: Structure and physiological

activity, 3493 Neurons containing /-endorphin in rat brain exist separately from those

containing enkephalin: Immunocytochemical studies, 1591 Ontogenetic development of kainate neurotoxicity: Correlates with

glutamatergic innervation, 2025 Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512 Serotonin and substance P coexist in neurons of rat's central nervous

system, 1582 Synapse turnover: Mechanism for acquiring synaptic specificity, 2281

Neuron, dopaminergic Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,

1546 Neuron, noradrenergic

Central noradrenergic neurons visualized in thick sections by unlabeled antibody method: Transmitter-specific Golgi image, 2502

Neuron, parasympathetic Neurite outgrowth induced by a conditioned-medium factor bound to

culture substratum, 5210 Neuron, sensory

Growth cone formation in cultures of sensory neurons, 5226 Neuron, sympathetic

Nonequivalence of a-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons, 1016


Neuropeptide Biological activity of brain gastrin-like peptidic material in humans: Its

relationship with COOH-terminal octapeptide of cholecystokinin, 524 Bombesin: Specific binding to rat brain membranes, 5372 [Met5]Enkephalin content in brain regions of rats treated with lithium,

2991 Species specificity of cholecystokinin in gut and brain of several

mammalian species, 486 Neurospora crassa


Tyrosinase from Neurospora crassa: Amino acid sequence, 3635 Neurotoxin

Release of neurotransmitters and depletion of synaptic vesicles in cerebral cortex slices by (v-latrotoxin from black widow spider venom, 4016


Neurotransmitter -y-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310 -y-Aminobutyric acid receptors: Ultrastructural localization in

mammalian central nervous system by means of [3H]muscimol binding, 2977

-y-Aminobutyric acid receptors visualized in spinal cord cultures by 3H]muscimol autoradiography, 6281

--Aminobutyric acid transport modulated in nerve endings: Role of extracellular --aminobutyric acid and of cationic fluxes, 2981

L-Aspartate: A role in cone photoreceptor synaptic transmission in carp retina, 5205



[5-Methionine]enkephalin and [5-leucine]enkephalin released in vitro from rat globus pallidus, 3503

Neuromuscular transmission blocked by enzymatically active and inactive ,-bungarotoxin, 1029



Neurotrophic factor Factor from neurons increases the number of acetylcholine receptor

aggregates on cultured muscle cells, 4011 Neurotumor

Segregation of different cell lines in vitro with neuronal and glial properties from stem cell line of rat neurotumor RT4, 6305

Niche overlap Does environmental variability limit niche overlap? 5085

Nicotiana tabacum Herbicide-resistant mutants of Nicotiana tabacum: Direct selection in

vitro, 5104 RNA-dependent RNA polymerase of tobacco plants, 2122

Nictitating membrane reflex Pyramidal cells identified as critical elements in hippocampal neuronal

plasticity during learning, 1572 Nitration

Electrophilic and free radical nitration of benzene and toluene with various nitrating agents, 1045


Nitrogenase Mutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343 Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery in

heterocysts isolated from Anabaena variabilis, 6271 Nitrogenase and nitrogenase reductase associate and dissociate with each

catalytic cycle, 2699 Nitrogenase reductase

Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery in heterocysts isolated from Anabaena variabilis, 6271

Nitrogenase and nitrogenase reductase associate and dissociate with each catalytic cycle, 2699

Nitrogen fixation Hydrogenase activity expressed in free-living Rhizobium japonicum,

3258 Mutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343 Nitrogenase activity and 55Fe-labeled nitrogenase: High recovery in

heterocysts isolated from Anabaena variabilis, 6271 Nitrogenase and nitrogenase reductase associate and dissociate with each

catalytic cycle, 2699 Nitrophenyl ether

Protein crosslinking and affinity labeling: High yield photoreagents, 3564 4-Nitroquinoline 1-oxide

Neoplastic transformation of human dcliploid fibrohlast cells by chemical carcinogens, 1334

Nitrosoguanidine, N-methyl-N'-nitro-N- 06-Methylguanine: Repair in adapted Escherichia coli, 6017 Temperature-sensitive RNA polymerase II mutations in Chinese hamster

ovary cells, 405 N-Nitrosomethylurea

Neoplastic transformation of rat mammary cells exposed to 7,12-dimethylbenz[a]anthracene or N-nitrosomethylurea in cell culture, 3836




Non-negativity Structure determination of crystalline substances by diffraction


Norepinephrine a-Adrenergic receptors in caudate nucleus selectively labeled by

[3H]dihydroergocryptine in presence of' spiperone-blocked dopamine receptors, 2249

Calcium leakage as cause of high resting tension in vascular smooth muscle from spontaneously hypertensive rat, 1605



Presynaptic and postsynaptic c-adrenoceptors in rat heart membranes: Positive homotropic cooperativity of presynaptic binding, 6285

Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus, 4509

Norharman Comutagenic effect of norharman and harman with

2-acetylaminofluorene derivatives, 928 Novobiocin


Energy coupling in DNA gyrase and mechanism of action of novobiocin, 4838

Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity, 1773

Nuclear body Estrogen receptor binding and transcriptional activity: Role in

stimulation of hyperestrogenism and nuclear bodies, 2781 Nuclear magnetic resonance

[Aspl,Ile5]- and [Phe4,Tyr8]angiotensin II: Correlation of biological activity and solution conformation, 3630

Bioenergetics and glycolysis in anaerobic Escherichia coli cells: 31p nuclear magnetic resonance studies, 2244


Deuterium nuclear magnetic resonance investigation of effects of proteins and polypeptides on hydrocarbon chain order in model membrane systems, 4657



Heme disorder in hemoproteins: Proton nuclear magnetic resonance characterization, 5755

High-resolution 31p nuclear magnetic resonance study of rat liver mitochondria, 1796


Isotopic (180) shift in 31p nuclear magnetic resonance applied to a study of enzyme-catalyzed phosphate-phosphate exchange and phosphate (oxygen)-water exchange reactions, 200

Methylglyoxal: Isolation from liver, 4317 Oxygen adduct intermediate in bacterial luciferase reaction: 13C nuclear

magnetic resonance determination of structure, 5860 Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa

cells observed by high-resolution 31p nuclear magnetic resonance, 891 Phosphate (oxygen)-water exchange reaction catalyzed by human

prostatic acid phosphatase, 4784 31p nuclear mangetic resonance signals in brain detected by in vivo and

freeze-trapped assays, 4925 Protected homo-oligopeptide structure: Model for preferred

conformation of a linear methionine heptapeptide in chloroform, 4647 Structure of a poly(adenosine diphosphoribose) monomer:

2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809 Topographical analysis of regulatory and metal ion binding sites on


Nuclease Nucleosomes associated with newly replicated DNA have altered

conformation, 2717 Nuclease Si

see also S1 endonuclease Highly repetitious inverted terminal repeat sequence from Oxytricha

macronuclear DNA: Isolation and characterization, 2626 Nuclease, staphylococcal

Altered nucleosome spacing in newly replicated chromatin from Friend leukemia cells, 5903


Nucleic acid see also Deoxyribonucleic acid; Ribonucleic acid Drug-nucleic acid interactions: Conformational flexibility at

intercalation site, 828 Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181 Nucleolus


Nucleon Failure of Drell-Yan parton model to account for production of J/' in

nucleon-nucleon interactions, 5770 Nucleoprotein

Origin of DNA replication in papovavirus chromatin is recognized by endogenous endonuclease, 5964

Subject Index 6391

Nucleosome Altered nucleosome spacing in newly replicated chromatin from Friend

leukemia cells, 5903 Altered nucleosome structure containing DNA sequences complementary

to 19S and 26S ribosomal RNA in Physarum polycephalum, 1116 Assembly of new nucleosomal histones and new DNA into chromatin,

2130 Butyrate suppression of histone deacetylation leads to accumulation of



Compact oligomers anId nucleosome phasing, 3583 Decomposition of linking number of a closed ribbon: Problem from

molecular biology, 3557 H-1 histone in rat liver nuclei: Displacement and aberrant methylation

in vitro after half-saturation of chromatin with polycations, 5773 Histone packing in nucleosome core particle of chromatin, 3649 Minichromosome from BK virus as template for transcription in vitro,

1126 Mononucleosome DNA conformation: Circular dichroism analysis, 4759 Nucleosome core particle of chromatin: Sequence of histone arrangement

along DNA, 4184 Nucleosome rearrangement in human chromatin during UV-induced

DNA repair synthesis, 4238 Nucleosomes associated with newly replicated DNA have altered

conformation, 2717 Nucleotide sequence

see also Deoxyribonucleic acid sequence Bacterial clone synthesizing proinsulin, 3727 Bacterial plasmids constructed that contain nucleotide sequence for

bovinle corticotropin-/-lipotropin precursor, 6021 BK virus DNA: Cleavage map and sequence analysis, 2150 Bleomycin: Interaction with DNA, 5983 Complementary sequences 1700 nucleotides apart form ribonuclease III

cleavage site in Escherichia coli ribosomal precursor RNA, 3593 Complete nucleotide sequence of a 16S ribosomal RNA gene from

Escherichia coli, 4801 Displacement-loop replication initiation sequence in animal

mitochondrial DNA exists as a family of discrete lengths, 677 DNA sequence from histidine operon control region: Seven histidine

codons in a row, 4281 Homologous nucleotide sequences between prokaryotic and eukaryotic

mRNAs: 5'-End sequence of mRNA of lipoprotein of Escherichia coli outer membrane, 2190


Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis, 3881


Nucleosome core particle of chromatin: Sequence of histone arrangement along DNA, 4184

Nucleotide sequence at junction between coding regioin of adenovirus 2 hexon messenger RNA and its leader sequence, 5822

Nucleotide sequence homology at 3' termini of RNA from vesicular stomatitis virus and its defective interfering particles, 3225

Nucleotide sequence of ampicillin resistance gene of Escherichia coli plasmid pBR322, 3737

Nucleotide sequence of an insertion element, IS1, 615 Nucleotide sequence of attenuator region of histidine operon of

Escherichia coli K-12, 4276 Nucleotide sequence of leader region of phenylalanine operon of

Escherichia coli, 4271 nucleotide sequence of recognition site for restrictionl-modification

enzyme of Escherichia coli B, 2266 Nucleotide sequence of simian virus 40 small-t gene, 2160 Nucleotide sequences around origin of DNA replication similar in mouse

polyoma virus and simian virus 40, 162 Nucleotide sequences of separate origins of synthesis of bacteriophage

G4 viral and complementary DNA strands, 1081 Nucleotide sequences related to transforming gene of avian sarcoma

virus are present in DNA of uninfected vertebrates, 4102 Nucleotide specificity in DNA scission by neocarzinostatin, 3603 Ovalbumin gene: A leader sequence in mRNA and DNA sequences at

exon-intron boundaries, 4853 Polyoma virus giant RNAs contain tandem repeats of nucleotide

sequence of entire viral genome, 4754 Potato spindle tuber and citrus exocortis viroids undergo no major

sequence changes during replication in two different hosts, 951 RNA sequencing with radioactive chain-terminating ribonucleotides,

5334 RNase Tl-resistant oligonucleotides derived from genomes of Akv and

MCF murine leukemia viruses: Characterization and mapping, 495 RNA transcribed from DNA at origin of phage fd single strand to

replicative form conversion, 645 Sequence of a mouse germ-line gene for variable region of

immunoglobulin light chain, 1485 Sequence of a RNA templated by 3'-OH RNA terminus of defective

interfering particles of vesicular stomatitis virus, 4704 Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608 Site-specific initiation of a DNA fragment: Nucleotide sequence of


bacteriophage G4 negative-strand inlitiation site (correction), 6337 Specific binding of tRNAAMet to 23S rRNA of Escherichia coli, 1071 Specific RNA sequences and gene products of MC29 avian acute

leukemia virus, 5874



6392 Subject Index

Structure of X att sites generated by int-dependent deletions, 5437 Structure of origin of DNA replication of bacteriophage fd, 50 3'-Terminal nucleotide sequence of encephalomyocarditis virus RNA

determilled by reverse tranlscriptase and chain-terminating inhibitors, 4257

Transcription termination: Nucleotide sequence at 3' end of tryptophan operon in Escherichia coli, 5442

Turnip yellow mosaic virus genome RNA: Nucleotide sequence at 5' extremity, 3168

Numerical method Connectivity as an alternative to boundary integral equations:

Construction of bases, 2059 Numerical solution

High accuracy finite difference approximation to solutions of elliptic partial differential equations, 2541

Nutrient concentration Dispersal in relation to carrying capacity, 2854

Nutrition see also Diet; Malnutrition; Starvation Nutritional inhibition of genetically determined renal disease and

autoimmunity with prolongation of life in kdkd mice, 2888

Obesity Different regulation of insulin receptors in intracellular (Golgi) and

plasma membranes from livers of obese and lean mice, 3302 Enzymatic defect in obese (ob/ob) mouse: Loss of thyroid-inlduced

sodium- and potassium-dependent adenosinetriphosphatase, 477 Olfaction

Olfaction: Binding specificity of radioactively labeled stimuli to an isolated olfactory preparation from rainbow trout (Salmo gairdneri), 4679

Olfactory bulb Olfactory axons and synapse formation regenerated in forebrain after

bulbectomy in neonatal mice, 5230 Oligodendroglia

Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation, 2521

Oligo-isoadenylate synthetase Isolation of two interferon-induced translational inhibitors: A protein

kinase and an oligo-isoadenylate synthetase, 4734 Oligonucleotide


Oligonucleotide synthesis Genes for human insulin: Chemical synthesis, 5765 Mononucleotides added to oligoribonucleotide acceptors with T4 RNA

ligase, 1270 Oligosaccharide

see also Polysaccharide Hepatic receptor that specifically binds oligosaccharides containing

fucosyl (Y1-3 N-acetylglucosamine linkages, 2215 Oligosaccharide chains are trimmed during synthesis of envelope

glycoprotein of vesicular stomatitis virus, 754 Oligosaccharides containing glucose and mannose in glycoproteins of

thyroid gland, 1162 Oncogenesis

Nucleotide sequences related to transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates, 4102

One-phase Stefan problem One-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084 Oocyte, mouse

Protein synthesis: Absolute rates during meiotic maturation of mammalian oocytes in vitro, 4160

Oocyte, rat Rat oocyte maturation in vitro: Relief of cyclic AMP inhibition by

gonadotropins, 4369 Oocyte, Xenopus laevis


Cloned single repeating units of 5S DNA direct accurate transcription of 5S RNA when injected into Xenopus oocytes, 2849


DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for a nuclear factor, 4873


In vivo phosphorylation of synthetic peptide substrate of cyclic AMP-dependent protein kinase, 248

Transcription of cloned tRNA gene fragments and subfragments injected into oocyte nucleus of Xenopus laevis, 1176



Xenopus oocytes: Long-term growth and differentiation in a defined medium, 5534

Oogenesis Protein synthesis: Absolute rates during meiotic maturation of

mammalian oocytes in vitro, 4160 Operator, lac


How lac repressor recognizes lac operator, 3578


Operator, pseudo-differential New class of pseudo-differential operators, 582 On positivity of pseudo-differential operators, 4673

Operator, singular integral Inversion problem for singular integral operators: C*-approach, 4668

Operon, L-arabinose DNA sequence of araBAD promoter in Escherichia coli B/r, 4724

Operon, histidine DNA sequence from histidine operon control region: Seven histidine

codons in a row, 4281 Nucleotide sequence of attenuator region of histidine operon of

Escherichia coli K-12, 4276 Operon, lac



Evolution of /-galactosidase, 113 /-Galactosidase from mutant strain 13 PO of Escherichia coli:

Functional properties, 1892 Operon, phenylalanine


Operon, transport Membrane protein identified as a histidine transport component in

Salmonella typhimurium, 5447 Operon, trp





Ophryotrocha labronica Inhibition of putrescine synthesis blocks development of polychete

Ophryotrocha labronica at gastrulation, 1039 Opiate

see also Receptor, opiate /-Endorphin: Biosynthesis from /-lipotropin and a larger molecular

weight precursor in rat pars intermedia, 4719 /-Endorphin induces nonconvulsive limbic seizures, 5221 /-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /3-endorphin, 2950 /-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /3-endorphin (correction), 5244 Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,

1546 Opiate-like peptide

Energy conformation study of Met-enkephalin and its D-Ala2 analogue and their resemblance to rigid opiates, 7

Energy conformation study of Met-enkephalin and its D-Ala2 analogue anId their resemblance to rigid opiates (correction), 6337

Opioid peptide Pro-opiocortin, a precursor to opioid peptides and corticotropin, 669

Organ of Corti Synapses involving auditory nerve fibers in primate cochlea, 4582

Orientation factor Intramolecular energy transfer in molecules with large number of

conformations, 1050 Ornithine carbamoyltransferase (EC 2.1.3.3)


Ornithine decarboxylase (EC 4.1.1.17) Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated


Nerve growth factor increases activity of ornithine decarboxylase in rat brain, 1021

Nerve growth factor: Intraventricular administration induces ornithine decarboxylase in peripheral tissues of rat, 2512

Ornithine decarboxylase activity in Escherichia coli modulated by positive and negative effectors, 4699


Ovarian ornithine decarboxylase regulation in immature, pubescent, and pseudopregnant rat, 2530

Ornithine transcarbamylase see Ornithine carbamoyltransferase

Oscillatory mode Spatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313 Ouabain

Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens, 2864

Ouabain-resistant mutations induced in C3H 1OT1/2 mouse cells by ultraviolet light, 3363

Ovalbumin Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936 Ovalbumin: A secreted protein without a transient hydrophobic leader

sequence, 94 Ovary


Ovulation Protein synthesis: Absolute rates during meiotic maturation of

mammalian oocytes in vitro, 4160




Ovum Polycationic macromolecules inhibit cilia-mediated ovum transport in

rabbit oviduct, 4413 Owl monkey

see Aotus trivirgatus Oxidative phosphorylation

see also Phosphorylation High-resolution 31p nuclear magnetic resonance study of rat liver

mitochondria, 1796 Stoichiometry of vectorial H+ movements coupled to electron transport

and to ATP synthesis in mitochondria, 5296 Oxolinic acid

Antagonists of DNA gyrase inihibit repair and recombination of' UV-irradiated phage A, 4125

Oxygen Hydrogen peroxide production, chemiluminescence, and respiratory


Isotopic (180) shift in 31p nuclear magnetic resonance applied to a study of enzyme-catalyzed phosphate-phosphate exchange and phosphate (oxygen)-water exchange reactions, 200


Oxygen-mediated heterogeneity of apo-low-density lipoprotein, 3173 Partitioning of bound inorganic phosphate during medium and

intermediate phosphate-water oxygen exchainge reactions of yeast inorganic pyrophosphatase, 3133

Photodestructionl of pheomelanin: Role of oxygen, 5395 Rationale for stabilization of oxygen-labile enzymes: Application to a

clostridial hydrogenase, 3640 Oxygen affinity

Protein crosslinking and affinity labeling: High yield photoreagents, 3564 Oxygen binding

Cooperativity in 02 binding to iron porphyrins, 1052 Macromolecular transducer as illustrated by trout hemoglobin IV, 4310 Model compounds for T state of hemoglobin, 564 Oxygen binding by hemoglobinl, 5462 Reciprocal effects in human hemoglobin: Direct measurement of

dimer-tetramer association. constant at partial oxygen saturation, 5493 Oxygen exchange kinetics

Phosphate (oxygen)-water exchange reaction catalyzed by human prostatic acid phosphatase, 4784

Oxyhemocyanin Laccase and oxyhemocyanin: Magnetic susceptibility studies, 3019

Oxymyoglobin Fe-O2 bonding and oxyheme structure in myoglobin, 2291

5,8-Oxyretinoic acid 5,8-Oxyretinoic acid isolated from sinall intestine of vitamin A-deficient


rats dosed with retinoic acid (correction), 5244 Oxytocin

Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus, 2044

Oxytricha Highly repetitiotus inverted terminal repeat sequence from Oxytricha

macronuclear DNA: Isolation and characterization, 2626 Oxytricha fallax

Macroniuclear DNA of the hypotrichous ciliate Oxytricha fallax, 4992

Pain Morphine sulfate stimulates adenylate cyclase in mouse caudate nuclei,

1546 Paleobotany

Miocene angiosperm leaf tissues: Ultrastructure and cytochemistry, 3263 Palmitoyl-coenzyme A


Pancreas see also Cell, pancreatic acinar Monolayer formation in cultured whole pancreatic islets promoted by

3-isobutyl-1-methylxanthine, 1897 Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260 Thyrotropin-releasing hormone: High concentration in pancreatic islets,

4265 Papaverine


Papillomavirus Two types of human papillomaviruses in lesions of epidermodysplasia

verruciformis, 1537 Papio cynocephalus


Papovavirus Origin of DNA replication in papovavirus chromatin is recognized by

endogenous endonuclease, 5964 Parainfluenza

Repertoire of antiviral antibodies expressed by somatic cell hybrids, 1510 Paralysis


Paramecium tetraurelia Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312 K+-resistant mutants and "adaptation" in Paramecium, 5645

Subject Index 6393

Paramyxovirus Infection with paramyxoviruses stimulates synthesis of cellular


Paranaric acid Interaction of mycobacterial polymethylpolysaccharides with paranaric


Parasitemia Trypanosome-mediated suppression of humoral immunity in mice:

Mechanisms, 3923 Parathyrin

see also Preproparathyrin Parathyroid hormone- and calcitonin-activated adenylate cyclases:


Role of anions in parathyroid hormone release from dispersed bovine parathyroid cells, 876

Parathyroid hormone see Parathyrin

Parkinson disease [l8F]Fluoro-dopa, an analogue of dopa, and its use in direct external


Pars distalis /-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /3-endorphin, 2950 /3-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /-endorphin (correction), 5244 Pars intermedia

/-Endorphin: Biosynthesis from /-lipotropin and a larger molecular weight precursor in rat pars intermedia, 4719

/3-Lipotropin, y-lipotropin, and f3-endorphin in rat pars intermedia: In vitro biosynthesis and chemical characterization, 31].53

Parthenogenesis Teratocarcinomas: Somatic cell origin, 2834

Particle, fundamental Symmetry and causality properties of physical fields, 1609

Partition function Locality principle in wave mechanics, 5270

Partition identity Lie algebras and classical partition identities, 578

Partitioning Ligand-promoted transfer of proteins between phases: Spontaneous and

electrically helped, 779 Pedersen fetuin

Embryonal carcinoma cells: Growth in serum-free medium, 1844 Pemphigus

Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase, 459

Penicillanic acid, 6-#f-bromo- 6-/-Bromopenicillanic acid, a potent /3-lactamase inhibitor, 4145

Penicillin Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by

Cephalosporium acremonium CW-19 and its mutanlts, 6253 Cellular division in Escherichia coli: Series of mutants of E. coli altered

in penicillin-binding proteins, 664 Depsipeptide substrate used for trapping acyl-enzyme intermediates of

penicillin-sensitive D-alanine carboxypeptidases, 84 Escherichia coli mutant isolated lacking penicillin-sensitive D-alanine

carboxypeptidase IA, 2631 Penicillinase (EC 3.5.2.6)

6-/f-Bromopenicillanic acid, a potent /-lactamase inhibitor, 4145 Nucleotide sequence of ampicillin resistance gene of Escherichia coli

plasmid pBR322, 3737 Penicillinase coded by Escherichia coli plasmid R6K: Partial amino acid

sequence, 3732 Protein micelles formed from amphiphilic membrane proteins, 5306

Pepsin Cold pepsin digestion: Method to produce Fv fragment from human

immunoglobulin M, 2649 Peptide

see also Corticotropin-inhibiting peptide; Neuropeptide; Polypeptide Peptide, depsi-

Depsipeptide substrate used for trapping acyl-enzyme intermediates of penicillin-sensitive D-alaninle carboxypeptidases, 84

Peptide, gastrointestinal Biological activity of brain gastrin-like peptidic material in humans: Its

relationship with COOH-terminal octapeptide of cholecystokinin, 524 Species specificity of cholecystokinin in gut and brain of several

mammalian species, 486 Peptide map


Polyoma virus T antigens translated in vitro, 5917 Peptide metabolism

Escherichia coli mutants defective in dipeptidyl carboxypeptidase, 5998 Peptide structure


Peptide synthesis see also Protein synthesis Somatostatin: Conformationally restricted bicyclic analogs, 2636 Translational control of transcription termination at attenuator of

Escherichia coli tryptophan operon, 5988 Peptide, vasoactive intestinal




6394 Subject Index

Peptidoglycan Escherichia coli mutant isolated lacking penicillin-sensitive D-alanine

carboxypeptidase IA, 2631 Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127 Peptidyl dipeptidase (EC 3.4.15.1)

Escherichia coli mutants defective in dipeptidyl carboxypeptidase, 5998 Renovascular hypertension reversed by antibodies specific for

angiotensin-converting enzyme, 5702 Perception

Law of perceptual stability: Abstract foundations, 2049 Law of perceptual stability: Well-definedness and validity, 2535

Permittivity Electronic properties of some protein-methylglyoxal complexes, 315

Peroxidase Conjugation of poly-L-lysine to albumin and horseradish peroxidase:

Method of enhancing cellular uptake of proteins, 1872 Hydrogen peroxide production, chemiluminescence, and respiratory


Peroxidase-antiperoxidase Binding to chromosomes of herpes simplex-related antigens in

biochemically transformed cells, 3288 Central noradrenergic neurons visualized in thick sections by unlabeled

antibody method: Transmitter-specific Golgi image, 2502 Myelin basic protein demonstrated immunocytochemically in

oligodendroglia prior to myelin sheath formation, 2521 Ultrastructural antibody localization of (l2-macroglobulin in

membrane-limited vesicles in cultured cells, 4359 Peroxisome


Catalase: Synthesis in two cell-free protein-synthesizing systems and in rat liver, 4344

pH Colicin Ia: Effect on Escherichia coli proton electrochemical gradient,

2579 Fluorescence probe measurement of iintralysosomal pH in living cells and

perturbation of pH by various agents, 3327 Transmembrane pH gradient: Role in epinephrine transport by

chromaffin granule membrane vesicles, 3713 Phagocyte

Attack of sea urchin eggs by dogfish phagocytes: Model of phagocyte-mediated cellular cytotoxicity, 1825

Phagocytosis S-Adenosyl-L-methionine-mediated methylation required for human

monocyte chemotaxis, 3928 Membrane sialic acid on target particles modulates their phagocytosis by

trypsin-sensitive mechanism on human monocytes, 3831 Pharmacological desensitization

Receptor-controlled tracer efflux from sealed membrane fragments: Kinetic analysis, 3756

Phaseolus vulgaris Messenger RNA for G1 protein of French bean seeds: Cell-free

translation and product characterization, 3196 Phase transition

Gel to liquid crystal transition of synthetic phosphatidylcholines, 2258 Hysteresis effects of C1H4 and C2H4 in regions of solid-phase transitions,

4664 Interacting enzyme systems at steady state: Location of phase transition

in approximations of mean field type, 3015 Initeracting enzyme systems at steady state: Further Monte Carlo

calculations on two-state molecules, 5260 Protein-lipid interactions in bilayer membranes: Theoretical study, 1616 Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955 Temperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325 Phenotypic selection

Phenotypic selection: Effect on genetic change at individual loci, 6168 Phenylhydrazine


Phenylketonuria Diet, genetics, and mental retardation interaction between


Pheomelanin Photodestruction of pheomelanin: Role of oxygen, 5395

Pheromone Induced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479 Mating factor a: Inactivation and chemical alteration by cells and

spheroplasts of yeast, 1304 Philanthus zebratus Cresson

Alternative mating strategies in digger wasp Philanrthus zebratus Cresson, 1901

Phonotaxis Steering responses of flying crickets to sound and ultrasound: Mate

attraction and predator avoidance, 4052 Phosphatase


Phosphate see also Pyrophosphate; Transport, phosphate Isotopic (180) shift in 31P nuclear magnetic resonance applied to a study

of enzyme-catalyzed phosphate-phosphate exchange and phosphate (oxygen)-water exchange reactions, 200


Partitioning of bound inorganic phosphate during medium and intermediate phosphate-water oxygen exchange reactions of' yeast inorganic pyrophosphatase, 3133

Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa cells observed by high-resolution 31p nuclear magnetic resonance, 891

5'-Phosphate-polyribonucleotide kinase Enzymatic conversion of 5'-phosphate-terminated RNA to 5'-di- and

triphosphate-terminated RNA, 4793 Phosphate potential

High-resolution 31p nuclear magnetic resonance study of rat liver mitochondria, 1796

Phosphatidic acid dichlorides Phospholipid synthesis: Oxazaphospholanes and dioxaphospholanes as

intermediates, 4074 Phosphatidylcholine

Gel to liquid crystal transition of synthetic phosphatidylcholines, 2258 Identification and properties of two methyltransferases in conversion of

phosphatidylethanolamine to phosphatidylcholine, 1718 Phosphatidylcholine: Enzymatic synthesis and rapid translocation by

two methyltransferases in erythrocyte membranes, 2348 Transmitter release: Changes induced by ion-containing liposomes, 5214

Phosphatidylcholine, dipalmitoyl Brillouin light scattering measurement of elastic properties of aligned

multilamella lipid samples, 1792 Phosphatidylcholine vesicle

Geometric packing constraints in egg phosphatidylcholine vesicles, 308 Phosphatidylethanolamine



Phosphatidylinositol Myoinositol and phosphatidylinositol metabolism in synaptosomes from

galactose-fed rats, 4568 Phosphatidylinositol bisphosphate

Physicochemical properties of triphosphoinositide altered by nicotinic ligands, 784

Phosphatidylserine Phosphatidylserine: Interaction with mast cells, 4997

Phosphatidylserine vesicle Temperature dependence of calcium-induced fusion of sonicated

phosphatidylserine vesicles, 4325 Phosphodiesterase



Phosphodiesterase I (EC 3.1.4.1) Structure of a poly(adenosine diphosphoribose) monlomer:

2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809 Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32)


Phosphoglucomutase (EC 2.7.5.1) Homologous genes for enolase, phosphogluconate dehydrogenase,


Phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) Homologous genes for enolase, phosphogluconate dehydrogenase,


Phosphoglycerate kinase (EC 2.7.2.3) Existence of only a single functional pool of adenosine triphosphate in

human erythrocytes, 2825 Phospho-2-keto-3-deoxyheptonate aldolase (EC 4.1.2.15)

Iron, an essential element for biosynthesis of aromatic compounds, 4810 Phospholipase

lonophore A23187- and thrombin-induced platelet aggregation: Independence from cycloxygenase products, 818


Phospholipase A2 Neuromuscular transmission blocked by enzymatically active and

inactive /-bungarotoxin, 1029 Phospholipase A2 (EC 3.1.1.4)



Indomethacin: Low concentrations inhibit phospholipase A2 of rabbit polymorphonuclear leukocyte, 2955


Phospholipase C (EC 3.1.4.3) Cardiolipin: Stereospecifically spin-labeled analogue and its specific

enzymic hydrolysis, 1227 Phospholipase D (EC 3.1.4.4)


Phospholipid Antigenic phospholipids introduced into plasma membrane of


Arsoniumphospholipid in algae, 4262 Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669 Phosphate metabolites in lymphoid, Friend erythroleukemia, and HeLa

cells observed by high-resolution 31p nuclear magnetic resonance, 891




Phospholipid bilayers in the transition zone: Nanosecond relaxation processes, 3011

Phospholipid synthesis: Oxazaphospholanes and dioxaphospholanes as intermediates, 4074

Phospholipid vesicle stimulation of proacrosin activation, 149 Photochemical technique for measuring lateral diffusion of spin-labeled

phospholipids in membranes, 4661 Rapid conformational changes of cytochrome P-450: Effect of

dimyristoyl lecithin, 5955 Secondary cytotoxic T lymphocytes induced by purified HLA-A and

HLA-B antigens reconstituted into phospholipid vesicles, 5688 Therapy of leishmaniasis: Superior efficacies of liposome-encapsulated

drugs, 2959 Thyroid phospholipids: Effect on interaction of thyrotropin with thyroid

membranes, 5301 Phospholipid vesicle

Entrapment of metaphase chromosomes into phospholipid vesicles (lipochromosomes): Carrier potential in gene transfer, 1361

Entrapment of metaphase chromosomes into phospholipid vesicles (lipochromosomes): Carrier potential in gene transfer (correction), 3009


Phosphoprotein Ontogeny of synaptic phosphoproteins in brain, 4037

Phosphorescence Ligands containing heavy atoms: Perturbation of phosphorescence of a

tryptophan residue in binding site of wheat germ agglutinin, 1324 Phosphoribosylpyrophosphate synthetase

see Ribosephosphate pyrophosphokinase Phosphorothioate

Adenosine 5'-O-([-y-l10]-thio)triphosphate chiral at the -y-phosphorus: Stereochemical consequences of reactions catalyzed by pyruvate kinase, glycerol kinase, and hexokinase, 2230

Phosphorus Adenosine 5'-O-([-l0]-y-thio)triphosphate chiral at the -y-phosphorus:


Phosphorylation see also'Oxidative phosphorylation; Protein phosphorylation Glucose binding and transport proteins extracted from fast-growing

chicken fibroblasts, 5427 3-Hydroxy-3-methylglutaryl coenzyme A reductase: Regulation of

enzymatic activity by phosphorylation and dephosphorylation, 3678 Phosphorylation in vivo and in vitro of human histocompatibility


Phosphorylation of eukaryotic protein synthesis initiation factors, 108 Phosphoryl transfer

Adenosine 5'-O-([y-180]-y-thio)triphosphate chiral at the Y-phosphorus: Stereochemical consequences of reactions catalyzed by pyruvate kinase, glycerol kinase, and hexokinase, 2230

Photinus ignitus Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905 Photinus marginellus

Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P. marginellus (Coleoptera: Lampyridae), 905

Photobacterium fischeri Myristic acid stimulation of bacterial bioluminescence in "aldehyde"

moutants, 266 Photobacterium phosphoreum

Bacterial bioluminescence: Isolation of in vivo emitter, 833 Photobiology

Charge stabilization mechanism in visual and purple membrane pigments, 2558

Photobleaching Molecular motion in membranes determined using periodic pattern

photobleaching, 2759 Photochemistry



Photochemical technique for measurinlg lateral diffusion of spin-labeled phospholipids in membranes, 4661


Photodissociation Photosensitivity of liganded hemoproteins and their metal-substituted

analogues, 21 Picosecond photodissociation and subsequent recombination processes in

carbon monoxide hemoglobin, 573 Photoisomerization


Photolysis Oxy- and carbonmonoxy hemoglobin: Spectroscopic studies after pulsed

optical excitation, 5255 Photodestruction of pheomelanin: Role of oxygen, 5395 Photosensitivity of liganded hemoproteins and their metal-substituted

analogues, 21 Stochastic theory of ligand migration in biomolecules, 26

Photolysis, flash Flash photolysis of human serum albumin: Characterization of indole

triplet absorption spectrum and decay at ambient temperature, 1172 Photoreagent

Protein crosslinking and affinity labeling: High yield photoreagents, 3564

Subject Index 6395

Photoreceptor y-Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310 L-Aspartate: A role in cone photoreceptor synaptic transmission in carp

retina, 5205 Cyclic GMP injected into retinal rod outer segments increases latency

and amplitude of response to illumination, 5218 Opposing effects of calcium and barium in vertebrate rod

photoreceptors, 1587 Responses to light of solitary rod photoreceptors isolated from tiger

salamander retina, 3507 Photosynthesis


Nitrogen electron nuclear double resonance and proton triple resonance experiments on bacteriochlorophyll cation in solution, 2296


Photosynthetic characteristics and organization of chlorophyll in marine dinoflagellates, 1801

Photosynthetic unit size, carotenoids, and chlorophyll-protein composition of Prochloron sp., a prokaryotic green alga, 2301

Proton translocation: A third site in green plant photosynthetic electron transport, 6031

Photosystem I Photosynthetic characteristics and organization of chlorophyll in marine

dinoflagellates, 1801 Physarum polycephalum



Physical field Symmetry and causality properties of physical fields, 1609

Phytohemagglutinin see also Hemagglutinin Mammalian lectin-like substanlce: Isolation, preliminary characterization,

and interferon antagonistic effect, 2333 Phytomitogen

Transgiutaminase activity in human lymphocytes: Early activation by phytomitogens, 1157

Phytotoxin Reaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935 Picloram

Herbicide-resistant mutants of Nicotiana tabacum: Direct selection in vitro, 5104

Picornavirus 3'-Terminal nucleotide sequence of encephalomyocarditis virus RNA

determined by reverse transcriptase and chain-terminatirng inhibitors, 4257

Pigeon crop-sac assay Two fragments from fibrinolysin digests of ovine prolactin:


Pig, germfree Natural killing and antibody-dependent cellular cytotoxicity are

independent immune functions in Minnesota miniature swine, 5127 Pineal gland


Pinocytosis Conjugation of methotrexate to poly(L-lysine) increases drug transport

and overcomes drug resistance in cultured cells, 3867 Conjugation of poly-L-lysine to albtimin and horseradish peroxidase:

Method of enhancing cellular uptake of proteins, 1872 Receptor-mediated binding of glycoproteins, glycoconjugates, and

lysosomal glycosidases by alveolar macrophages, 1399 Pituitary

see also Cell, pituitary tumor; Pars intermedia Coordinate control of corticotropin, /-lipotropin, and /3-endorphin

release in mouse pituitary cell cultures, 4972 Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis, 4306 Corticotropin-inhibiting peptide from human pituitary glands: Isolation,

characterization, and synthesis (correction), 6337 Dense plexus of substance P immunoreactive nerve terminals in

eminentia medialis of primate hypothalamus, 1013 /-Endorphin: Biosynthesis from /-lipotropin and a larger molecular

weight precursor in rat pars intermedia, 4719 Estrogen control of prolactin synthesis in vitro, 5946 Extrahypophysial distribution of corticotropin as functiol of brain size,

994 /3-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /-endorphin, 2950 /T-Lipotropin is major opioid-like peptide of human pituitary and rat

pars distalis: Lack of significant /3-endorphin (correction), 5244 Pituitary somatotrophs contain [Met]enkephalin-like immunoreactivity,

6134 Regional dissociation of /-endorphin and enkephalin contenlts in rat

brain and pituitary (correction), 1608 Placenta

see also Cell, placental Antigens of human trophoblasts: Role in normal and abnormal

pregnancies, 1947 Normal human placentas contain RNA-directed DNA polymerase

activity like that in viruses, 6263



6396 Subject Index

Planetary system Stability in dynamical astronomy, 5743

Plasma Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810 Fibrinogen synthesis in serum-free hepatocyte cultures: Stimulation by

glucocorticoids, 5506 Ionized gas in Seyfert and radio-galaxy nuclei: Observational model, 540 Plasma radioiron kinetics in man: Explanation for effect of plasma iron

concentration, 1559 Plasmacytoma


Plasmid see also Deoxyribonucleic acid, plasmid Bacterial clone synthesizing proinsulin, 3727 Bacterial plasmids constructed that contain nucleotide sequence for

bovine corticotropin-/-lipotropin precursor, 6021 Chicken ovalbumin is synthesized and secreted by Escherichia coli, 5936 ColEl-derived plasmid copy-number mutant: Isolation and

characterization, 5869 Complete nucleotide sequence of a 16S ribosomal RNA gene from

Escherichia coli, 4801 "Conjugal" transfer of plasmid DNA among oral streptococci, 3484 Construction and characterization of 2.5-kilobase procollagen clone, 5417 Construction and properties of chimeric plasmids in Bacillus subtilis,

1428 DNA cloning in Bacillus subtilis, 1433 DNA modifying enzymes of Agrobacterium tu-mefaciens: Effect of DNA


DNA sequence of araBAD promoter in Escherichia coli B/r, 4724 Enterotoxin-deficient mutants of Escherichia coli: Isolation and

characterization, 1384 Escherichia coli plasmid bearing functional gene G of bacteriophage

1SX174: Construction and characterization, 774 Induced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479 Low molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673 Nucleotide sequence of ampicillin resistance gene of Escherichia coli

plasmid pBR322, 3737 Nucleotide sequence of an insertion element, IS1, 615 Penicillinase coded by Escherichia coli plasmid R6K: Partial amino acid

sequence, 3732 Plasmid-encoded protein required for replication in vitro of plasmid

R6K, 5381 Proteins conferred by the virulence-specifying plasmid of Agrobacterium

tumefaciens C-58, 3796 Recombinant bacterial plasmid constructed containing a chick pro-a2

collagen gene sequence, 5846 Transposition of plasmid DNA segmernts specifying hydrocarbon

degradation and their expression in various microorganisms, 3109 Plasmid ColEl

Construction of plasmid-phage hybrid: Use of hybrid to demonstrate ColEl DNA replication in viuo in absence of ColEl-specified protein, 2200


Modification of DNA by the benz[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 415



Plasmid, F Cell-cell interactions in conjugating Escherichia coli: Purification of F

pili with biological activity, 1237 Plasmid, F-like


Plasmid, hybrid Construction of plasmid-phage hybrid: Use of hybrid to demonstrate

ColEl DNA replication in vivo in absence of ColEl-specified protein, 2200

Cosmids: Type of plasmid gene-cloning vector packageable in vitro in bacteriophage X heads, 4242

Hemoglobin switching in sheep: Only the -y gene is in active conformation in fetal liver but all the 3 and -y genes are in active conformation in bone marrow, 5884


Ovalbumin gene: Structural sequences in native chicken DNA are not contiguous, 2205

Structure of yeast phenylalanine-tRNA genes: Intervening DNA segment within region coding for tRNA, 190

Transformation of yeast, 1929 Plasmid pMB9

Genetic recombination and complementation between bacteriophage T7 and cloned fragments of T7 DNA, 2276

Plasmid pUBIlO Molecular cloning of genetically active fragments of Bacillus DNA in

Bacillus subtilis and properties of vector plasmid pUBIlO, 1423 Plasmin

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: Possible mechanism of inflammatory demyelination, 1554


Direct fluorescent assay of urokinase and plasminogen activators of normal and malignant cells: Kinetics and inhibitor profiles, 750

Noncovalent interaction of NH2-terminal fragment of human somatotropin with COOH-terminal fragment of human choriomammotropin to generate growth-promoting activity, 1700

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII), 1998

Plasmin (EC 3.4.21.7) Two fragments from fibrinolysin digests of ovine prolactin:


Plasminogen activator Degradation of basic protein in myelin by neutral proteases secreted by




Lack of correlation between tumorigenicity and level of plasminogen activator in fibroblasts transformed by Rous sarcoma virus, 4967

Nerve growth factor: A protease that can activate plasminogen, 5497 Plasminogen activator (EC 3.4.21.-)


Plasmodium chabaudi Malaria merozoites isolated: Release of Plasmodium chabaudi

merozoites from schizonts bound to immobilized concanavalin A, 5081 Plasmodium falciparum

Erythrocytic mechanism of sickle cell resistance to malaria, 1994 Immunization against malaria with antigen from Plasmodium

falciparum cultivated in vitro, 5665 Plasmodium knowlesi


Plasmolysis Phage repressor inactivated in a permeable cell system: Role of recBC

DNase in induction, 3569 Plastid

Maize plastid gene expressed during photoregulated development, 3060 Plastohydroquinone


Platelet Fatty acid cyclooxygenase from human aorta: Sensitivity to acetylation

by aspirin, 5181 Fibronectin is the collagen receptor on platelet membranes, 5864 lonophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Venom coagglutinin: Activator of platelet aggregation dependent on von

Willebrand factor, 4514 Polarized optical spectroscopy

Fe-02 bonding and oxyheme structure in myoglobin, 2291 Poliovirus

Inhibition of translation by poliovirus: Inactivation of a specific initiation factor, 2732

Proteins of poliovirus: Cell-free synthesis and processing, 5807 O4-(5'-Uridylyl)tyrosine is the bond between geinome-linked protein and

RNA of poliovirus, 4868 Poly(adenosine diphosphoribose)

Structure of a poly(adenosine diphosphoribose) monomer: 2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809

Poly(adenosine diphosphoribose) synthase Structure of a poly(adenosine diphosphoribose) monomer:

2'-(5"-Phosphoribosyl)-5'-adenosine monophosphate, 809 Polyadenylate


Hydrolysis of poly(A) to adenine nucleotides by purified poly(A) polymerase, 2085

Poly(A)-adjacent sequences of mammary tumor virus RNA: Differential expression in murine mammary cells, 5797

Polyadenylate polymerase see Polynucleotide adenylyltransferase

Poly(ADP-ribose) ADP-ribosylated nuclear proteins: Purification by covalent

chromatography on dihydroxyboryl polyacrylamide beads and characterization, 1111

Polyamine Inhibition of putrescine synthesis blocks development of polychete

Ophryotrocha labronica at gastrulation, 1039 Polyethylene oxide


Polyglycine Energies of polypeptides: Theoretical conformational study of

polyglycine using quantum mechanical partitioning, 2071 Poly(L-lysine)

Bacteriorhodopsin: Molecular orientation within the purple membrane of Halobacterium halobium, 4320

Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells, 3867


H-1 histone in rat liver nuclei: Displacement and aberrant methylation in vitro after half-saturation of chromatin with polycations, 5773

Polycationic macromolecules inhibit cilia-mediated ovum transport in rabbit oviduct, 4413




Polymorphism see also Protein polymorphism ADHS electromorph of Drosophila melanogaster: Structural analysis,

5609 Founder effect and number of private polymorphisms observed in

Amerindian tribes, 1904 Genetic variation at a highly polymorphic esterase locus in Drosophila

pseudoobscura, 5090 Mathematical theory of group selection: Structure of group selection in


Mutation rates in tribal Amerindians: Indirect estimates, 5585 Polymorphism of DNA sequence adjacent to human ,/-globin structural

gene: Relationship to sickle mutation, 5631 Structural flexibility of isozyme variants: Genetic variants in Drosophila

disguised by cofactor and subunit binding, 395 Two HLA-linked loci controlling the fourth component of human

complement, 5165 Polynucleotide adenylyltransferase (EC 2.7.7.19)

Hydrolysis of poly(A) to adenine nucleotides by purified poly(A) polymerase, 2085

Polynucleotide, mercurated Preferential transcription of ovalbumin gene in isolated hen oviduct

nuclei by RNA polymerase B, 686 Polynucleotide phosphorylase

see also Polyribonucleotide nucleotidyltransferase Isotopic (180) shift in 31P nuclear magnetic resonance applied to a study

of enzyme-catalyzed phosphate-phosphate exchange and phosphate (oxygen)-water exchange reactions, 200

Polyoma virus DNAs of simian virus 40 and polyoma direct synthesis of viral tumor

antigens and capsid proteins in Xenopus oocytes, 6073 Mouse preimplantation embryos infected with simian virus 40 and

polyoma virus, 999 Nucleotide sequences around origin of DNA replication similar in mouse

polyoma virus and simian virus 40, 162 Origin of DNA replication in papovavirus chromatin is recognized by

endogenous endonuclease, 5964 Polyoma virus giant RNAs contain tandem repeats of nucleotide

sequence of entire viral genome, 4754 Polyoma virus T antigens translated in vitro, 5917 Transcription of a defective polyoma virus genome, 69 Tumor antigen(s) in cells productively infected by wild-type polyoma

virus and mutant NG-18, 79 Polypeptide

Amino-terminal amino acid sequence of major structural polypeptides of avian retroviruses: Sequence homology between reticuloendotheliosis virus p30 and p30s of mammalian retroviruses, 2708

Energies of polypeptides: Theoretical conformational study of polyglycine using quantum mechanical partitioning, 2071


Polypeptide in eukaryotic initiation factors that crosslinks specifically to 5'-terminal cap in mRNA, 4843

Polyphenylalanine synthesis Cycloheximide resistance can be mediated through either ribosomal

subunit, 3158 Two chromatographically separable forms of Escherichia coli elongation

factor Tu, 1140 Polyploidy

Influence of homoeologous chromosomnes on gene-dosage effects in allohexaploid wheat (Triticum aestivum ,.), 1446

Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Does 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in

oocytes of Xenopus laevis? 5030 Polysaccharide

see also Lipopolysaccharide; Oligosaccharide Interaction of mycobacterial polymethylpolysaccharides with paranaric



Pompeiu problem Pompeiu's problem on discrete space, 3555

Ponasterone A Ecdysteroid receptor in a cultured cell line of Drosophila melanogaster,


6039 Porous medium

One-phase Stefan problem and porous medium diffusion equation: Continuity of the solution in n space dimensions, 2084

Porphyrin see also Metalloporphyrin Cooperativity in 02 binding to iron porphyrins, 1052

Potassium see also Transport, potassium Acetylcholine-receptor-mediated ion flux in electroplax membrane


Cole-Moore effect in the frog node, 3254 Generation of b-wave currents in skate retina, 5727 K+-resistant moutants and "adaptation" in Paramecium, 5645

Potato Reaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935

Subject Index 6397

Potato spindle tuber viroid Potato spindle tuber and citrus exocortis viroids undergo no major

sequence changes during replication in two different hosts, 951 Prealbumin

Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy, 4499


Pregnancy Antigens of human trophoblasts: Role in normal and abnormal

pregnancies, 1947 Prekeratin

Different intermediate-sized filaments distinguished by immunofluorescence microscopy, 5034

Preproinsulin Major polyadenylylated transcription products and the genes active in

their synthesis in a rat insulinoma identified, 3249 Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260

Prepromelittin Amino-acid sequence of honeybee prepromelittin synthesized in vitro,

701 Preproparathyrin

Pre-proparathyroid hormone: Amino-acid sequence, chemical synthesis, and biological studies of precursor region, 2616

Primary mixed leukocyte reaction Lymphoid dendritic cells are potent stimulators of primary mixed

leukocyte reaction in mice, 5132 Pristane


Proacrosin Phospholipid vesicle stimulation of proacrosin activation, 149

Probability distribution Joint probability distribution of invariants comprising determinantal

inequalities: Heuristic derivation, 2545 .Prochloron


P'rocollagen Codistribution of pericellular matrix proteins in culttred fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944 Construction and characterization of 2.5-kilobase procollagen clone, 5417 Embryonic neural retina collagen: In vitro synthesis of high molecular

weight forms of type II plus a new genetic type, 3235 Product space Dimension of product spaces, 4671 Progesterone



Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus, 2044

Progesterone-binding protein: Amino acid sequence, 5516 Xenopus laevis oocytes: Induction of maturation by a steroid linked to a

polymer, 2353 Program, dual

Clark's Theorem on linear programs holds for convex programs, 1624 Proinsulin

Bacterial clone synthesizing proinsulinm, 3727 Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260

Prolactin Different regulation of insulin receptors in intracellular (Golgi) and

plasma membranes from livers of obese and lean mice, 3302 Estrogen control of prolactin synthesis in vitro, 5946 Growth hormone modulation of murine erythroleukemia cell growth in

vitro, 3437 Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294 Two fragments from fibrinolysin digests of ovine prolactin:


Proliferative glomerulonephritis Type C RNA virus-specific antibody in human systemic lupus

erythematosus demonstrated by enzymoimmunoassay, 2463 Proline

Acid catalysis of formation of slow-folding species of RNase A: The reaction is proline isomerization, 4764

Prolyl hydroxylase half reaction: Peptidyl prolyl-independent decarboxylation of' -ketoglutarate, 2145

Proline,2-oxoglutarate dioxygenase (EC 1.14.11.2) Collagen biosynthetic activities expressed in lymphocytic cells, 1379 Prolyl hydroxylase half reaction: Peptidyl prolyl-independent

decarboxylation of (v-ketoglutarate, 2145 Prolyl hydroxylase

see Proline,2-oxoglutarate dioxygenase Pro-opiocortin

Pro-opiocortin, a precursor to opioid peptides and corticotropin, 669 Properdin

Complement C3 convertase: Cell surface restriction of /lH control and generation of restriction on neuraminidase-treated cells, 2416

Initiation of alternative pathway of complement: Recognition of activators by bound C3b and assembly of entire pathway from six isolated proteins, 3948

Prophage Early events and mechanisms in induction of bacterial SOS functions:

Analysis o(f phage repressor inactivation process in vivo, 1657 Phage repressor inactivated in a permeable cell system: Role of recBC

DNase in induction, 3569



6398 Subject Index

Propidium diiodide Sugar pucker geometries at intercalation site of propidium diiodide into

miniature RNA and DNA duplexes in solution, 2553 Prostaglandin

Coronary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: Comparison with prostacyclin and other prostanoids, 3522


Hapten mimic elicits antibodies recognizing prostaglandin E2, 2689 Indomethacin: Low concentrations inhibit phospholipase A2 of rabbit

polymorphonuclear leukocyte, 2955 Mechanism of rapid antigonadotropic action of prostaglandins in

cultured luteal cells, 1344 Vasoactive intestinal peptide: Potent stimulator of adenosine 3':5'-cyclic

monophosphate accumulation in gut carcinoma cell lines in culture, 2772

Prostaglandin synthase (EC 1.14.99.1) Fatty acid cyclooxygenase from human aorta: Sensitivity to acetylation

by aspirin, 5181 Prostate


Protein factor that inhibits binding and promotes release of androgen-receptor complex from nuclear chromatin, 5969

Prostatic acid phosphatase Phosphate (oxygen)-water exchange reaction catalyzed by human

prostatic acid phosphatase, 4784 Prosthecochloris aestuarii


Protamine H-1 histone in rat liver nuclei: Displacement and aberrant inethylation

in vitro after half-saturation of chromatin with polycations, 5773 Protease

see also Serine protease Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339 Degradation of basic protein in myelin by neutral proteases secreted by



Protein see also Lipoprotein; Membrane protein; Metalloprotein; Peptide;

Phosphoprotein; Polypeptide; Transport, protein Protein adsorption

Cell adhesion to substrates containing adsorbed or attached IgG, 1366 Protein, allosteric

see also Emnzyme, allosteric Reciprocal effects in human hemoglobin: Direct measurement of

dimer-tetramer association constant at partial oxygen saturation, 5493 Proteinase

Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase, 459

Protein association Self-association of hemoglobin /SH chains is linked to oxygenation, 311

Protein, bacterial Identification of host protein necessary for bacteriophage morphogenesis

(groE gene product), 131 Role of the host in virus assembly: Cloning of Escherichia coli groE gene

and identification of its protein product, 136 Protein, blood serum

Fotunder effect and number of private polymorphisms observed in Amerindian tribes, 1904

Protein, blue fluorescence Bacterial bioluminescence: Isolation of in vivo emitter, 833

Protein C Bovine protein C: Amino acid sequence of the light chain, 5889

Protein, calcium-dependent regulator Ca2+-dependent protein phosphorylation system in membranes from

various tissues, and its activation by "calcium-dependent regulator", 5432

Calcium-dependent regulator protein: Localization in mitotic apparatus of eukaryotic cells, 1867

Microtubule assembly-disassembly controlled by calcium-dependent regulator protein, 3771

Protein, cap-binding Polypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843 Protein, capsid


Protein, chorion Silkmoth chorion proteins: Sequence analysis of products of a multigene

family, 390 Protein, coat


Protein, copper see also Copper Blue copper site in oxidized azurin characterized by extended x-ray



Laccase and oxyhemocyanin: Magnetic susceptibility studies, 3019


Protein, core Structural markers on core protein p30 of murine leukemia virus:

Functional correlation with Fv-l tropism, 4170 Protein, cro

cro protein of bacteriophage X: Mechanism of action, 1783 Protein crosslinking

Protein crosslinking and affinity labeling: High yield photoreagents, 3564 Protein, cyclic nucleotide-binding

Cyclic nucleotide-binding proteins detected by photoaffinity labeling in nucleus and cytoplasm of bovine liver, 5286

Protein deficiency Protein deficiency and energy restriction in young cebus monkeys, 1600

Protein degradation Protein degradation in diabetes and starvation, 2093

Protein, deoxyribonucleic acid-binding Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647 Protein, dnaB

Escherichia coli dnaB mutant defective in DNA initiation: Isolation and properties of dnaB protein, 799

Protein, dnaG Site-specific initiation of a DNA fragment, 1652 Site-specific initiation of a DNA fragment: Nucleotide sequence of


bacteriophage G4 negative-strand initiation site (correction), 6337 Protein folding

Acid catalysis of formation of slow-folding species of RNase A: The reaction is proline isomerization, 4764

Enzyme catalysis: Energetics, 5250 Protein folding: Respective roles of short- and long-range interactions,

559 Protein tertiary structure: Formation on a computer, 554 Refolding of a bifunctional enzyme and its monofunctional fragment,

5979 Synthesis of phage M13 coat protein and its assembly into membranes in

vitro, 1754 Protein, fusion

Fusion protein of Sendai virus purified: NH2-terminal sequence generated during precursor activation, 2737

Protein, Gl Messenger RNA for G1 protein of French bean seeds: Cell-free

translation and product characterization, 3196 Protein, gag gene


Protein, gag-pol Biosynthesis of reverse transcriptase from Rauscher murine leukemia


Protein, gene 0.3 Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741 Protein, gene A

Enzymatic breakage of cohesive end site of phage X DNA: Terminase (ter) reaction, 4199

Protein, gene-5 Interaction of oligonucleotides with gene-5 protein of bacteriophage

M13: Photochemically induced dynamic inuclear polarization study, 5281

Protein, genome-linked 04-(5'-Uridylyl)tyrosine is the bond between genome-linked protein and

RNA of poliovirus, 4868 Protein, glucose-binding

Glucose binding and transport proteins extracted from fast-growing chicken fibroblasts, 5427

Protein, granulocyte-inducing Induction of normal differentiation in myeloid leukemia cells in vivo,

3781 Protein, heat shock


Protein, hybrid /-Galactosidase chimeras: Primary structure of a lac

repressor-/-galactosidase protein, 4824 Protein Ia

Protein Ia and lamB protein can replace each other in colnstitution of an active receptor for the same coliphage, 5636

Protein inducer Differential desensitization of functional adrenergic receptors in normal


Protein inhibitor Endogenous protein inhibitor of high affinity binding of --aminobutyric

acid to synaptic membranes of rat brain: Purification, 4024 Protein, inulin-binding myeloma

Sequence variation among heavy chains from inulinl-binding myeloma proteins, 1957

Protein, iron-sulfur see also Iron Cluster characterization in iron-sulfur proteilns by magnletic circular

dichroism, 5273 Protein isoelectric point

Protein degradation in diabetes and starvation, 2093 Protein kinase

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependenlt regulator", 5432




Cyclic AMP-dependent protein kinase mediates cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities, 862


Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: Mechanism of enzyme activation, 4744

Fluorescent photoaffinity labeling: Adenosine 3':5'-cyclic monophosphate receptor sites, 1199

Hemin: Effect on site-specific phosphorylation of eukaryotic initiation factor 2, 789

Interferon action: Two distinct pathways for inhibition of protein synthesis by double-stranded RNA, 5893

Isolation of two interferon-induced translational inhibitors: A protein kinase and an oligo-isoadenylate synthetase, 4734

Phosphorylation of eukaryotic protein synthesis initiation factors, 108 Protein synthesis initiation inhibited by oxidized glutathione: Activation

of a protein kinase that phosphorylates the a subunit of eukaryotic initiation factor 2, 4110


Specific regulation by steroid hormones of amount of type I cyclic AMP-dependent protein kinase holoenzyme, 223

Protein kinase (EC 2.7.1.37) In vivo phosphorylation of synthetic peptide stubstrate of cyclic

AMP-dependent protein kinase, 248 Mammalian protein kinase and phosphodiesterase activities inhibited by

a cyclic AMP-like compound isolated from higher plants, 4301 Ontogeny of synaptic phosphoproteins in brain, 4037 Protein kinase activity associated with avian sarcoma virus src gene

product, 2021 Regulation of protein synthesis: Activation by double-stranded RNA of a

protein kinase that phosphorylates eukaryotic initiation factor 2, 1121 Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction of Met-tRNAfMet binding factor with another initiation factor in formation of Met-tRNAfMet-40S ribosomal subunit complexes, 745

Translational control by hemin is due to binding to cyclic AMP-dependent protein kinase, 1148

Protein, lac carrier Functional lac carrier protein in cytoplasmic membrane vesicles isolated

from Escherichia coli: Temperature and pH dependence of dansyl-galactoside binding, 4214

Protein lamB Protein Ia and lamB protein can replace each other in constitution of an

active receptor for the same coliphage, 5636 Protein, LETS

see Fibronectin Protein, macrophage-inducing


Protein, matrix Matrix protein from Escherichia coli membranes forms

voltage-controlled channels in lipid bilayers, 3751 Protein, membrane

see Membrane protein Protein methylesterase

Protein methylesterase involved in bacterial sensing, 3659 Protein-methylglyoxal complex

Electronic properties of some protein-methylglyoxal complexes, 315 Protein micelle

Protein micelles formed from amphiphilic membrane proteins, 5306 Protein, mitochondrial

Low molecular weight Ca2+ carrier isolated from calf heart inner mitochondrial membrane, 2125

Protein, myelin basic Brain-derived fibroblast growth factor: Identity with a fragment of basic

protein of myelin, 4675 Multiple sclerosis cerebrospinal fluid: Components detected by

radioimmunoassay for myelin basic protein, 1976 Protein, myeloma

X2 light chains in normal mouse immunoglobulins, 1495 Protein, N gene

N gene protein of bacteriophage X identified, 2225 Protein, nonhistone


Nuclear antigens in Novikoff hepatoma: Purification, 1943 Protein, nuclear


Protein, periplasmic Proteins conferred by the virulence-specifying plasmid of Agrobacterium

tumefaciens C-58, 3796 Protein phosphorylation

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator", 5432

Depolarizing agents and cyclic nucleotides regulate phosphorylation of specific neuronal proteins in rat cerebral cortex slices, 5195

Hemin-controlled inhibitor of protein synthesis: Mode of action, 243 Hemin-controlled inhibitor of protein synthesis: Studies with factors

from rabbit reticulocytes, 2713

Subject Index 6399

In vivo phosphorylation of synthetic peptide substrate of cyclic AMP-dependent protein kinase, 248


Protein polymorphism see also Polymorphism Genetic variability: Theoretical study assuming stepwise production of

neutral and very slightly deleterious mutations, 919 Proteins in natural population: Subunit molecular weight and genetic

variability, 3359 Protein precursor

Precursors of three exported proteins in Escherichia coli, 1209 Preproinsulin: Detection and kinetic behavior in pancreatic islets, 1260

Protein, regulatory Estrogen receptor has enhanced affinity for

bromodeoxyuridine-substituted DNA, 4896 Promoter recognition by phage SPOl-modified RNA polymerase, 1185

Protein, retinol-binding Anti-idiotypic antibodies used as cell-surface receptor probes, 2443

Protein, rho RNA polymerase and rho in interact transcription termination: Coupled

ATPase, 4828 Protein, ribosomal

Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron microscopic determination, 270

Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron microscopic determination (correction), 2054

Conservation of ribosomal protein binding sites in prokaryotic 16S RNAs, 2859

Cotranscription of genes for RNA polymerase subunits /3 and f3' with genes for ribosomal proteins in Escherichia coli, 3891

Guanosinetriphosphatase activity dependent on elongation factor Tu and ribosomal protein L7/L12, 3192



Protein, sarc gene Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366

Protein, secreted Nucleotide sequence of ampicillin resistance gene of Escherichia coli

plasmid pBR322, 3737 Precursors of three exported proteins in Escherichia coli, 1209 Secreted nascent chains: Interaction with surrounding membrane in

Bacillus subtilis, 5922 Protein, secretory



Transformation-dependent secretion of low molecular weight protein by murine fibroblasts, 2767

Protein, storage Messenger RNA for Gl protein of French bean seeds: Cell-free

translation and product characterization, 3196 Zein messenger RNA: Purification and translation from maize

endosperm protein bodies, 696 Protein, streptococcal M

Streptococcal M protein: Repeating covalent structure, 3163 Protein, structural

Amino- and carboxyl-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus, 1404


Structural proteins of an ATP-driven potassium transport system in Escherichia coli, 3216

Protein structure Active site of bovine trypsin: Interactive computer surface graphics

approach, 5409 Amino acid sequence of /3 chain of human fibrinogen: Homology with "/

chain, 1731 /3 Bulge: Common small unit of nonrepetitive protein structure, 2574 Complete amino-acid sequence of a2 heavy chain of human IgA2

immunoglobulin of A2m(2) allotype, 966 Computerized multidimensional scaling used to compare


Diamagnetic anisotropy in proteins: Structural origins, 5475 Energies of polypeptides: Theoretical conformational study of

polyglycine using quantum mechanical partitioning, 2071 Glucose-induced conformational change in yeast hexokinase, 4848 Macromolecular shape and surface maps by solvent exclusion, 303 Method to assess similarity of protein structures, with applications to T4

bacteriophage lysozyme, 2180 Protected homo-oligopeptide structure: Model for preferred

conformation of a linear methionine heptapeptide in chloroform, 4647 Protein tertiary structure: Formation on a computer, 554 Thioredoxin induced by bacteriophage T4: Three-dimensional structure,

5827 Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276 Tyrosinase from Neurospora crassa: Amino acid sequence, 3635

Protein, sugar-binding Ligands containing heavy atoms: Perturbation of phosphorescence of a

tryptophan residue in binding site of wheat germ agglutinin, 1324



6400 Subject Index

Protein synthesis see also Peptide synthesis Albumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879 Aminoacyl-tRNA synthetases: Affinity labeling of ATP binding site by

2',3'-ribose oxidized ATP, 2088 Amphibian oocyte maturation and protein synthesis: Related inhibition

by cyclic AMP, theophylline, and papaverine, 1242 Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339 Bacterial elongation factor Tu: Novel properties, 1250 Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741 Binding and release of eukaryotic initiation factor eIF-2 and GTP during

protein synthesis initiation, 204 Biosynthesis of reverse transcriptase from Rauscher murine leukemia


Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104 Eukaryotic initiation factor 3 localized on native small ribosomal

subunits, 1389 Functionial covalent complex between elongation factor Tu and an analog

of lysyl-tRNA, 3075 Hemin-controlled inhibitor of protein synthesis: Mode of action, 243 Hemin: Effect on site-specific phosphorylation of etkaryotic initiation

factor 2, 789 Messenger RNA is conserved during drying of drought-tolerant moss

Tortula ruralis, 842 Mitochondrial translation products: Variation associated with

male-sterile cytoplasms in maize, 3841 Mutants of Escherichia coli altered in both genes coding for elongation

factor Tu, 4470 Mutations altering cellular localization of phage X receptor, an

Escherichia coli outer membrane protein, 5802 Origin of genetic code: Testable hypothesis based on tRNA structure,

sequence, and kinetic proofreading, 4334 Phosphorylation of eukaryotic protein synthesis initiation factors, 108 Protein synthesis: Absolute rates during meiotic maturation of

mammalian oocytes in vitro, 4160 Rate of macromolecular synthesis through cell cycle of Saccharomyces

cerevisiae, 4384 Regulation of protein synthesis: Activation by double-stranded RNA of a

protein kinase that phosphorylates eukaryotic initiation factor 2, 1121 Specific binding of messenger RNA and methionyl-tRNAfMet by same

initiation factor for eukaryotic protein synthesis, 209 Protein synthesis, cell-free


Catalase: Synthesis in two cell-free protein-synthesizing systems and in rat liver, 4344

Cell-free synthesis of leaf protein: Identification of apparent precursor of small subunit of ribulose-1,5-bisphosphate carboxylase, 655



Globin mRNAs are primers for transcription of influenza viral RNA in vitro, 4886


In vitro inhibition of protein synthesis by purified cores from vaccinia virus, 175

Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map units, 2165

Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749 Messenger RNA for Gl protein of French bean seeds: Cell-free

translation and product characterization, 3196 mRNA-dependent synthesis of a glycosylated subunit of human

chorionic gonadotropin in cell-free extracts derived from ascites tumor cells, 1768

mRNA populations analyzed by cDNA.mRNA hybrid-mediated inhibition of cell-free protein synthesis, 1217

Ovalbumin: A secreted protein without a transient hydrophobic leader sequence, 94

Polypeptide encoded by avian sarcoma virus src gene: Identification, 1567

Positive control of D-serine deaminase synthesis in vitro, 1695 pppA2'p5'A2'p5'A: Inhibitor of protein synthesis synthesized with

enzyme fraction from interferon-treated cells, 256 Precursors of three exported proteins in Escherichia coli, 1209 Processing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399 Proteins of poliovirus: Cell-free synthesis and processing, 5807 Rat liver fatty acid synthetase mRNA translated in a cell-free system

derived from wheat germ, 730 Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction of Met-tRNAfMt binding factor with another initiation factor in formation of Met-tRNAfMet-40S ribosomal subunit complexes, 745


Rous sarcoma viral RNA translation inhibited by a specific oligodeoxyribonucleotide, 285

Streptomycin causes misreading of natural messenger by interacting with ribosomes after initiation, 275


Protein synthesis inhibition Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with

fragment A from diphtheria toxin, 5319 Disulfide bond connecting the chains of ricin, 1096 Disulfide bond connecting the chains of ricin (correction), 4067 Hemin-controlled inhibitor of protein synthesis: Studies with factors

from rabbit reticulocytes, 2713 Interferon action: Two distinct pathways for inhibition of protein

synthesis by double-stranded RNA, 5893 Mutants of human diploid fibroblasts resistant to diphtheria toxin:

Isolation and characterization, 3337 Oligonucleotide inhibitor of protein synthesis made in extracts of

interferon-treated chick embryo cells: Comparison with mouse low molecular weight inhibitor, 1167

Protein synthesis initiation inhibited by oxidized glutathione: Activation of a protein kinase that phosphorylates the a subunit of eukaryotic initiation factor 2, 4110

Protein synthesis in rabbit reticulocytes: A ribosomal factor that reverses inhibition of protein synthesis in heme-deficient lysates, 4858


Protein, transformation-specific Processing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399 Protein turnover

Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle, 1369

Protein, viral Cells nonproductively transformed by Abelson murine leukemia virus


Influenza virus proteins: Identity, synthesis, and modification analyzed by two-dimensional gel electrophoresis, 3625


Proteins of poliovirus: Cell-free synthesis and processing, 5807 Viral proteins in mouse mammary tumors detected by

immunoperoxidase staining of paraffin sections, 1524 Protein, water-insoluble



Prothrombin Vitamin K-dependent carboxylase: A hydroperoxide intermediate in the

reaction, 5413 Proton pump


Fluorescence probe measurement of intralysosomal pH in living cells and perturbation of pH by various agents, 3327

Molecular mechanisms for proton transport in membranes, 298 Secondary protein-chromophore interactions at Schiff base linkage in

bacteriorhodopsin: Molecular mechanism for proton pumping, 4642 Proton translocation



Protoplast, mesophyll Reaction to phytotoxins in a potato population derived from mesophyll

protoplasts, 4935 Pseudomonas aeruginosa


Pseudomonas cytochrome c551 at 2.0 A resolution: Enlargement of cytochrome c family, 2674

Psoralen DNA unwinding induced by photoaddition of psoralen derivatives and


Genetic recombination in Escherichia coli treated with psoralen and light: Topography and kinetics, 2373

Structure of psoralen-crosslinked ribosomal RNA from Drosophila melanogaster, 1642

Psychobiology [Met5]Enkephalin content in brain regions of rats treated with lithium,

2991 Pulvomycin


Purine metabolism Purinogenic immunodeficiency diseases: Selective toxicity of

deoxyribonucleosides for T cells, 5011 Purine methylation


Purine nucleoside phosphorylase Purine metabolism in cultured human fibroblasts from patients deficient


Purine synthesis Adenosine kinase initiates major route of ribavirin activation in cultured

human cell line, 3042 Purine metabolism in cultured human fibroblasts from patients deficient





Puromycin Nascent peptide as sole attachment of polysomes to membranes in

bacteria, 814 Putrescine

Inhibition of putrescine synthesis blocks development of polychete Ophryotrocha labronica at gastrulation, 1039

Pyridine nucleotide Interaction of methotrexate, folates, and pyridine nucleotides with


Regulation of Ca2+ release from mitochondria by oxidation-reduction state of pyridine nucleotides, 1690

Pyridoxal 5'-phosphate Syncatalytic conformational changes in aspartate aminotransferase

determined by hydrogen-deuterium exchange, 145 Pyridoxine

Deficiency of vitamin B6 in carpal tunnel syndrome: Biochemical evidence based on a crossover clinical study, 3410

Pyrimidine dimer Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in

vitro DNA synthesis on irradiated templates, 3037 Pyrochlorophyllide


Pyrophosphatase, inorganic Partitioning of bound inorganic phosphate during mnedium and

intermediate phosphate-water oxygen exchange reactions of yeast inorganic pyrophosphatase, 3133

Pyrophosphate Sodium pyrophosphate inhibition of RNA.DNA hybrid degradation by

reverse transcriptase, 5329 Pyruvate decarboxylase

see Pyruvate dehydrogenase (lipoate) Pyruvate dehydrogenase (lipoate) (EC 1.2.4.1)


Pyruvate dehydrogenase multienzyme complex Pyruvate dehydrogenase multienzyme complex from Escherichia coli:

Mechanism of action, 4877 Rapid intramolecular coupling of active sites in pyruvate dehydrogenase

complex of Escherichia coli: Mechanism for rate enhancement in a multimeric structure, 5386

Pyruvate kinase (EC 2.7.1.40) Adenosine 5'-O- (I-y-180ly-thio)triphosphate chiral at the -y-phosphorus:


Existence of only a single functional pool of adenosine triphosphate in human erythrocytes, 2825

Growth state-dependent phenotypes of adult hepatocytes in primary monolayer culture, 1834

Quantum mechanics Energies of polypeptides: Theoretical conformational study of

polyglycine using quantum mechanical partitioning, 2071 Nonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 1627 Quantum yield

Photosensitivity of liganded hemoproteinls and their metal-substituted analogues, 21

Quark Failure of Drell-Yan parton model to account for production of J/T in

nucleon-nucleon interactions, 5770 Quasi-stellar object

Chronometric cosmology: Redshift-magnitude relation for quasi-stellar objects, 535

Quinacrine Altered pattern of replication of human chromosomes in a human

fibroblast-mouse cell hybrid, 1470 Base ratio, DNA content, and quinacrine-brightness of human

chromosomes, 3382 Quinuclidinyl benzilate

Muscarinic cholinergic receptors in murine lymphocytes: Demonstration by direct binding, 2902

Quota method Congressional apportionment: Quota methods are still non-unique, 3537

Rabies virus Monoclonal antibodies against rabies virus produced by somatic cell

hybridization: Detection of antigenic variants, 3938 Radiation, ionizing

Unulsual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt-Jakob disease, and scrapie, 6268

Radioautography see Autoradiography

Radioimmunoassay Aminlo-terminal amino acid sequence of major structural polypeptides of


Bacterial clone synthesizing proinsulin, 3727 Cholecystokinin-like immunoreactivity localized in isolated nerve

terminals, 6324 Coordinate control of corticotropin, /-lipotropin, and /3-endorphin

release in mouse pituitary cell cultures, 4972 Corticotropin, lipotropin, and /-endorphin production by a human

nonpituitary tumor in culture: Evidence for common precursor, 5160 Crossreacting determinants in variant-specific surface antigens of

African trypanosomes, 1989

Subject Index 6401

/-Endorphin-like immunoreactivity appears in human ventricular cerebrospinal fluid upon analgesic electrical stimulation, 5170


Fibronectin synthesis by epithelial crypt cells of rat small intestine, 5548 Glucose-6-phosphate dehydrogenase deficiency: Biochemical

mechanisms, 1979 Hapten mimic elicits antibodies recognizing prostaglandin E2, 2689 Immunoglobulin from Pacific hagfish, a primitive vertebrate, 5679 Isolation and characterization of normal crossreacting antigen: Homology

of its NH2-terminal amino acid sequence with that of carcinoembryonic antigen, 1.670


/-Lipotropin is major opioid-like peptide of human pituitary and rat pars distalis: Lack of significant /-endorphin (correction), 5244



Mixed recombinants of human growth hormone and chorionic somatomammotropin: Immunoreactivity and receptor binding, 5391


Multiple sclerosis cerebrospinal fluid: Components detected by radioimmtunoassay for myelin basic protein, 1976

Nerve growth factor in mouse and rat serum: Correlation between bioassay and radioimmunoassay determinations, 4042



Serological characterization of B-tropic viruses of C57BL mice: Possible origin by recombination of endogenotus N-tropic and xenotropic viruses, 4553


Species specificity of cholecystokinin in gut and brain of several mamnmalian species, 486

Tubulin from the yeast Saccharomyces cerevisiae identified, 4962 Radiology

Mathematical aspects of divergent beam radiography, 2055 Raman spectroscopy


Secondary protein-chromophore interactions at Schiff base linkage in bacteriorhodopsin: Molecular mechanism for proton pumping, 4642


Rana catesbeiana Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339 Rana exculenta

Cole-Moore effect in the frog node, 3254 Rat


Bilirubin catabolism stimulated in jaundiced Gunn rats by inducer of microsomal mixed-function monooxygenases, 682

"Dark-active" rat transformed into "light-active" rat by destruction of 24-hr clock: Function of 24-hr clock and synchronizers, 6276

EcoRI cleavage site variants of mitochondrial DNA molecules from rats, 909

Receptor, acetylcholine Acetylcholine receptor levels regulated by a cholinergic agonist in mouse

muscle cell cultures, 3488 Acetylcholine receptor localized in excitable membrane from electric


Acetylcholine-receptor-mediated ion flux in electroplax membrane microsacs (vesicles): Change in mechanism produced by asymmetrical distribution of sodium and potassium ions, 1703

Adenylate cyclase activity: Regulation mediated by muscarinic acetylcholine receptors, 1788

Channel open time and metabolic stability of synaptic and extrasynaptic acetylcholine receptors on cultured chick myotubes, 520

Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents, 1596

Distinct protein components from Torpedo marmorata membranes carry acetylcholine receptor site and binding site for local anesthetics and histrionicotoxin, 510

Factor from neurons increases the nlumber of acetylcholine receptor aggregates oni cultured muscle cells, 4011

Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata, 4329

Immunization of rats with polypeptide chains from torpedo acetylcholine receptor causes autoimmune response to receptors in rat muscle, 769


Muscarinic acetylcholine receptors in heart cell cultures, 5831 Myasthenic patients' immunoglobulin affects acetylcholine receptor

turnover: Selectivity of degradation process, 3422 Nerve extract induces increase and redistribution of acetylcholine

receptors on cloned muscle cells, 2035 Nonequivalence of (o-bungarotoxin receptors and acetylcholine receptors

in chick sympathetic neurons, 1016



6402 Subject Index

Receptor-controlled tracer efflux from sealed membrane fragments: Kinetic analysis, 3756

Specific immunosuppression of experimental autoimmune myasthenia gravis by denatured acetylcholine receptor, 4006


Receptor, ,B-adrenergic o-Adrenergic receptors in caudate nucleus selectively labeled by


Agonist-induced increase in apparent /-adrenergic receptor size, 228 Calcium leakage as cause of high resting tension in vascular smooth

muscle from spontaneously hypertensive rat, 1605 Differential desensitization of functional adrenergic receptors in normal


Epinephrine-induced elevation of guanosine 3':5'-cyclic monophosphate in isolated fat cells of rat, 2684

Receptor, t~-adrenergic. Adenylate cyclase activation through the /-adrenergic receptor:

Catecholamine-induced displacement of bound GDP by GTP, 4155 Receptor, y-aminobutyric acid

-y-Aminobutyric acid receptors: Autoradiographic localization in rat central nervous system by using [3H]muscimol, 1024

-y-Aminobutyric acid receptors: Quantitative visualization in hippocampus and area dentata demonstrated by [3H]muscimol autoradiography, 2516


Receptor, androgen Protein factor that inhibits binding and promotes release of

androgen-receptor complex from nuclear chromatin, 5969 Receptor, angiotensin


Receptor, bacteriophage Mutations altering cellular localization of phage X receptor, an

Escherichia coli outer membrane protein, 5802 Protein Ia and lamB protein can replace each other in constitution of an

active receptor for the same coliphage, 5636 Receptor, a-bungarotoxin

Nonequivalence of c(-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons, 1016

Receptor, cell-surface Anti-idiotypic antibodies used as cell-surface receptor probes, 2443 Epidermal growth factor: Biological activity requires persistent

occupation of high-affinity cell surface receptors, 5788 Human (HLA-A and HLA-B) and murine (H-2K and H-2D)



Receptor, cholinergic Histochemically distinct compartments in striatum of human, monkey,

and cat demonstrated by acetylthiocholinesterase staining, 5723 Muscarinic cholinergic receptors in murine lymphocytes: Demonstration

by direct binding, 2902 Receptor, choriogonadotropin


Receptor, collagen Fibronectin is the collagen receptor on platelet membranes, 5864

Receptor, dopamine (v-Adrenergic receptors in caudate nucleus selectively labeled by


Dopamine: Conformation at dopamine receptor, 2641 Multiple receptors for brain dopamine, 1153

Receptor, ecdysteroid Ecdysteroid receptor in a cultured cell line of Drosophila melanogaster,


6039 Receptor, epidermal growth factor


Receptor, estradiol Selective complexing of "nuclear" 5S estradiol receptor by serum

component, 5S-CA, 2664 Receptor, estrogen

Estrogenic activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs, 468

Estrogen receptor binding and transcriptional activity: Role in stimulation of hyperestrogenism and nuclear bodies, 2781

Estrogen receptor has enhanced affinity for bromodeoxyuridine-substituted DNA, 4896

Soluble biospecific macromolecule for purification of estrogen receptor, 3143

Receptor, gonadotropin Mechanism of rapid antigonadotropic action of prostaglandins in

cultured luteal cells, 1344 Receptor, histamine

Histamine Hi1 receptors identified in mammalian brain membranes with [3H]mepyramine, 6290


Receptor, hormone Fluorescent labeling of hormone receptors in viable cells: Preparation





Progesterone-binding protein: Amino acid sequence, 5516 Thyroid phospholipids: Effect on interaction of thyrotropin with thyroid

membranes, 5301 Receptor, insulin

Different regulation of insulin receptors in intracellular (Golgi) and plasma membranes from livers of obese and lean mice, 3302

Insulin binding to solubilized material from fat cell membranes: Evidence for two binding species, 2593


Receptor crosslinking or aggregation is important in insulin action, 4209 Receptor, lutropin


Receptor, muscarinic Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic

monlophosphate levels in neuroblastoma cells, 6295 Receptor, nicotinic

o-Bungarotoxin blocks nicotinic transmission in avian ciliary ganglion, 2999

Receptor, olfactory Olfaction: Binding specificity of radioactively labeled stimuli to an

isolated olfactory preparation from rainbow trout (Salmo gairdneri), 4679

Receptor, oligosaccharide Hepatic receptor that specifically binds oligosaccharides containing

fucosyl s1-.3 N-acetylglucosamine linkages, 2215 Receptor, opiate

Interaction of ligands with opiate receptors of brain membranes: Regulation by ions and nucleotides, 1713

Receptor, oxytocin Opposing effects of estradiol and progesterone on oxytocin receptors in

rabbit uterus, 2044 Receptor, serotonin


Receptor, sperm Egg surface glycoprotein receptor for sea urchin sperm bindin, 881

Receptor, target cell Natural species-restricted attachment of human and murine T

lymphocytes to various cells, 2396 Receptor, T-cell


Recombination see also Deoxyribonucleic acid, recombinant

Recombination distribution Multilocus recombination distributions: Classifications and comparisons,

6332 Recombination, genetic

Cosmids: Type of plasmid gene-cloning vector packageable in vitro in bacteriophage X heads, 4242

Escherichia coli recA gene product ireactivates phage X repressor, 4714 Genetic recombination and complementation between bacteriophage T7

and cloned fragments of T7 DNA, 2276 Genetic recombination between mouse type C RNA viruses: Mechanism

for endogenous viral gene amplification in mammalian cells, 923 Genetic recombination in Escherichia coli treated with psoralen and

light: Topography and kinetics, 2373 Homology-dependent cutting in trans of DNA in extracts of Escherichia

coli: Approach to enzymology of genetic recombination, 620 Identification of host protein necessary for bacteriophage morphogenesis

(groE gene product), 131' In vitro system from Escherichia coli that catalyzes generalized genetic

recombination, 3698 Role of the host in virus assembly: Cloning of Escherichia coli groE gene

and identification of its protein product, 136 Serological characterization of B-tropic viruses of C57BL mice: Possible


Single base-pair change creates a Chi recombinational hotspot in bacteriophage X, 96182

Spontaneous mitotic recombination occurs at the two-strand stage, 4436 Tumor promoter induces sister chromatid exchanges: Relevance to

mechanisms of carcinogenesis, 6149 Redox potential

Reductant-depenldent electron distribution among redox sites o(f laccase, 5245

Redshift Chronometric cosmology: Redshift-magnitude relation for quasi-stellar

objects, 535 Reductive titration

Reductant-dependent electron distribution among redox sites of laccase, 5245




Reflection Brilliant total reflection from a liquid-liquid interface, 5772

Regression Adaptive design in regression and control, 586

Regression, multiple Strong consistency of least squares estimates in multiple regression, 3034

Renal disease Immunologic function and renal disease in (NZB X NZW)F1 mice:

Influence of dietary restriction, 1500 Nutritional inhibition of genetically determined renal disease and

autoimmunity with prolongation of life in kdkd mice, 2888 Renin-angiotensin system



Renin (EC 3.4.99.19) Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623 Replica plating


Repressor, bacteriophage Bacteriophage X repressor: Interaction with nonoperator DNA containing

single-strand gaps, 5817 Escherichia coli recA gene product inactivates phage X repressor, 4714 Phage repressor inactivated in a permeable cell system: Role of recBC

DNase in induction, 3569 Repressor, hemin-controlled

Hemin: Effect on site-specific phosphorylation of eukaryotic initiation factor 2, 789

Repressor, lac Amino-terminal fragment of lac repressor binds specifically to lac

operator, 5851 How lac repressor recognizes lac operator, 3578

Reproductive cycle Corpus luteum angiogenic factor responsible for proliferation of

capillaries and neovascularization of corpus luteum, 847 Respiration

Hydrogen peroxide production, chemiluminescence, and respiratory burst of fertilization: Interrelated events in early sea urchin development, 3183

Restriction endonuclease see also Endonuclease; Restriction enzyme ATP-induced conformational changes in restriction endonuclease from

Escherichia coli K-12, 3099 Bacteriophage X carrying the Escherichia coli chromosomal region of

replication origin, 5099 Cloned human 18S ribosomal DNA segments: Molecular analysis, 5367 Construction and properties of chimeric plasmids in Bacillus subtilis,

1428 Displacement-loop replication initiation sequence in animal

mitochondrial DNA exists as a family of discrete lengths, 677 DNA modifying enzymes of Agrobacterium tumefaciens: Effect of DNA


Duplicated human a globin genes lie close together in cellular DNA, 5950 EcoRI cleavage site variants of mitochondrial DNA molecules from rats,

909 Endogenous viral genes of White Leghorn chicken: Common site of

residence and sites associated with specific phenotypes of viral gene expression, 5941

Excision of DNA segments introduced into cloning vectors by poly(dA.dT) joining method, 1763


Human mitochondrial DNA: Analysis of 7S DNA from origin of replication, 735

Intervening sequence of DNA identified in structural portion of a mouse /-globin gene, 725

Intragenic DNA spacers interrupt the ovalbumin gene, 1299 Inverted repeated DNA from Chinese hamster ovary cells studied with

cloned DNA fragments, 2679 Local mutagenesis: Method for generating viral mutants with base

substitutions in preselected regions of viral genome, 2170 Local mutagenesis: Method for generating viral mutants with base

substitutions in preselected regions of viral genome (correction), 4596 Low molecular weight RNA species encoded by a multiple drug

resistance plasmid, 3673 Mapping of linear and circular forms of mouse mammary tumor virus


Molecular cloning of genetically active fragments of Bacillus DNA in Bacillus subtilis and properties of vector plasmid pUBlO, 1423



Nucleotide sequence of an insertion element, IS1, 615 nucleotide sequence of recognition site for restriction-modification

enzyme of Escherichia coli B, 2266 Origin of DNA replication in papovavirus chromatin is recognized by

endogenous endonuclease, 5964 Ovalbumin gene: Cloning of natural gene, 3688 Ovalbumin gene: Structural sequences in native chicken DNA are not

contiguous, 2205

Subject Index 6403


Physical organization of ilvEDAC genes of Escherichia coli strain K-12, 89

Polymorphism of DNA sequence adjacent to human /-globin structural gene: Relationship to sickle mutation, 5631

Promoter recognition by phage SPOl-modified RNA polymerase, 1185 Recognition site of Escherichia coli B restriction enzyme on oXsBI and

simian virus 40 DNAs: Interrupted sequence, 2271 Recombinant bacterial plasmid constructed containing a chick pro-ea2

collagen gene sequence, 5846 "Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694 Sites of integration of reticuloendotheliosis virus DNA in chicken DNA,

3372 Vaccinia virus DNA: Visualization of an inverted terminal repetition,

4863 Restriction enzyme

Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders, 1222

Replication in mitochondrial DNA molecules from Drosophila melanogaster: Origin and direction, 3886

Reticulocyte Hemin-controlled inhibitor of protein synthesis: Studies with factors

from rabbit reticulocytes, 2713 Hemin: Effect on site-specific phosphorylation of eukaryotic initiation

factor 2, 789 Protein synthesis in rabbit reticulocytes: A ribosomal factor that reverses

inhibition of protein synthesis in heme-deficient lysates, 4858 Regulation of protein synthesis in rabbit reticulocyte lysates:

Purification and characterization of heme-reversible translational inhibitor, 3654

Reticulocyte lysate Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inhibition of interaction of Met-tRNAfet binding factor with another initiation factor in formation of Met-tRNAfMet-40S ribosomal subunit complexes, 745

Reticuloendotheliosis virus Amino-terminal amino acid sequence of major structural polypeptides of


Sites of integration of reticuloendotheliosis virus DNA in chicken DNA, 3372

Retina --Aminobutyric acid: Neurotransmitter candidate for cone horizontal

cells of catfish retina, 6310 L-Aspartate: A role in cone photoreceptor synaptic transmission in carp

retina, 5205 Cyclic GMP injected into retinal rod outer segments increases latency

and amplitude of response to illumination, 5218 Diamagnetic anisotropy and orientation of (y helix in frog rhodopsin and

meta II intermediate, 5471 Different time course of development for high-affinity choline uptake

and choline acetyltransferase in chick retina, 2525 DNA sequences amplified during chicken cartilage and neural retina

differentiation, 4451 Generation of b-wave currents in skate retina, 5727 Responses to light of solitary rod photoreceptors isolated from tiger

salamander retina, 3507 Synapse turnover: Mechanism for acquiring synaptic specificity, 2281

Retinoblastoma Model for incidence of embryonal cancers: Application to

retinoblastoma, 2453 X-ray sensitivity of diploid fibroblasts from patients with hereditary or

sporadic retinoblastoma, 3962 Retinohypothalamic tract

Neonatal suprachiasmatic nucleus ablation: Absence of functional and morphological plasticity, 6243

Retinoic acid 5,8-Oxyretinoic acid isolated from small intestine of vitamin A-deficient


rats dosed with retinoic acid (correction), 5244 Retrovirus

Amino-terminal amino acid sequence of major structural polypeptides of avian retrovirtuses: Sequence homology between reticuloendotheliosis virus p30 and p30s of mammalian retroviruses, 2708

Normal human placentas contain RNA-directed DNA polymerase activity like that in viruses, 6263

Reverse-phase evaporation Preparation of liposomes with large internal aqueous space and high

capture by reverse-phase evaporation, 4194 Reverse transcriptase

see Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid-dependent

Review Biochemistry of actomyosin-dependent cell motility (Review), 588 Global problems of geophysical fluid dynamics (Review), 34 Structure determination of crystalline substances by diffraction


Rhizobium japonicum Hydrogenase activity expressed in free-living Rhizobium japonicum,

3258 Rhizobium trifolii

Mutant strains of clover rhizobium (Rhizohium trifolii) that form nodules on soybean (Glycine max), 2343



6404 Subject Index

Rhodamine Direct visualization of binding, aggregation, and internalization of insulin

and epidermal growth factor on living fibroblastic cells, 2659 Fluorescent labeling of hormone receptors in viable cells: Preparation


Rhodopsin see also Bacteriorhodopsin Charge stabilization mechanism in visual and purple membrane

pigments, 2558 Diamagnetic anisotropy and orientation of a helix in frog rhodopsin and

meta II intermediate, 5471 Rho factor

see also Protein, rho Mutant RNA polymerase of Escherichia coli terminates transcription in

strains making defective rho factor, 294 Transcription termination: Nucleotide sequence at 3' end of tryptophan

operon in Escherichia coli, 5442 Rhynchosporium secalis

Rhynchosporoside, a host-selective toxin produced by Rhynchosporium secalis, the causal agent of scald disease of barley, 4339

Rhynchosporoside Rhynchosporoside, a host-selective toxin produced by Rhynchosporium

secalis, the causal agent of scald disease of barley, 4339 Ribavirin

Adenosine kinase initiates major route of ribavirin activation in cultured human cell line, 3042

Ribonuclease A Acid catalysis of formation of slow-folding species of RNase A: The

reaction is proline isomerization, 4764 Ribonuclease H

see Hybrid nuclease Ribonuclease III

Complementary sequences 1700 nucleotides apart form ribonuclease III cleavage site in Escherichia coli ribosomal precursor RNA, 3593

Ribonuclease M5 T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045 Ribonuclease P

Ribonuclease P: An enzyme with an essential RNA component, 3717 Ribonucleic acid

see also Hybridization, ribonucleic acid-deoxyribonucleic acid; Nucleic acid; Transport, ribonucleic acid


Ribonucleic acid, double-stranded Interferon action: Two distinct pathways for inhibition of protein

synthesis by double-stranded RNA, 5893 Oligonucleotide inhibitor of protein synthesis made in extracts of

interferon-treated chick embryo cells: Comparison with mouse low molecular weight inhibitor, 1167

pppA2'p5'A2'p5'A: Inhibitor of protein synthesis synthesized with enzyme fraction from interferon-treated cells, 256

Ribonucleic acid, heterogeneous nuclear Complex population of mRNA sequences in large polyadenylylated

nuclear RNA molecules, 5544 Evidence from UV transcription mapping in HeLa cells that

heterogeneous nuclear RNA is the messenger RNA precursor (correction), 1043

Immunoglobulin light chain mRNA is processed from large nuclear RNA, 342


Ribonucleic acid ligase Mononucleotides added to oligoribonucleotide acceptors with T4 RNA

ligase, 1270 T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045 Ribonucleic acid, mammalian

see also Ribonucleic acid, messenger, mammalian RNA content in human lymphocyte subpopulations, 1938

Ribonucleic acid, mercurated Mapping of adenovirus late promoters with nascent mercurated RNA,

1662 Ribonucleic acid, messenger


Messenger RNA is conserved during drying of drought-tolerant moss Tortula ruralis, 842


Ribonucleic acid, messenger, albumin Albumin production rates and albumin mRNA levels correlated in livers

of normal, diabetic, and insulin-treated diabetic rats, 5879 Functional albumin mRNA decreased during estrogen-induced

vitellogenin biosynthesis in avian liver, 5974 Ribonucleic acid, messenger, bacterial


Ribonucleic acid, messenger, bacteriophage Regulation of transcription of late genes of bacteriophage T7, 804

Ribonucleic acid, messenger, globin Globin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886 Globin mRNA: Synthesis in relation to cell cycle during induced murine

erythroleukemia differentiation, 3801


Hemoglobin switching in sheep: Only the y gene is in active conformation in fetal liver but all the /3 and y genes are in active conformation in bone marrow, 5884

Intervening sequence of a mouse /-globin gene is transcribed within 15S /-globin mRNA precursor, 1309

Translational control: Recognition of methylated 5' end and an internal sequence in eukaryotic mRNA by the initiation factor that binds methionyl-tRNAfMet, 650

Ribonucleic acid, messenger, histone Hatching in sea urchin Lytechinus pictus is accompanied by shift in

histone H4 gene activity, 4135 Ribonucleic acid, messenger, human


Ribonucleic acid, messenger, immunoglobulin Immunoglobulin K chain RNA in thymus T cells: Direct demonstration

by in situ hybridization, 2905 Immunoglobulin light chain mRNA is processed from large nuclear

RNA, 342 Variable and constant regions are separated in 10-kbase transcription

unit coding for immunoglobulin K light chains, 6044 Ribonucleic acid, messenger, insulin

Major polyadenylylated transcription products and the genes active in their synthesis in a rat insulinoma identified, 3249

Ribonucleic acid, messenger, interferon Does 3'-terminal poly(A) stabilize human fibroblast interferon mRNA in

oocytes of Xenopus laevis? 5030 Ribonucleic acid, messenger, a-lactalbumin

(v-Lactalbumin mRNA in 4-day lactating rat mammary gland, 4739 Ribonucleic acid, messenger, mammalian




mRNA populations analyzed by cDNA-mRNA hybrid-mediated inhibition of cell-free protein synthesis, 1217

Polypeptide in eukaryotic initiation factors that crosslinks specifically to 5'-terminal cap in mRNA, 4843

Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294 Translation of mRNA from calf thymus in wheat germ system: Evidence

for precursor of thymosin (Vl, 6007 Ribonucleic acid, messenger, melittin

Amino-acid sequence of honeybee prepromelittin synthesized in vitro, 701

Ribonucleic acid, messenger, methylated Biosynthesis of cytoplasmic polyhedrosis virus mRNA:

"Pretranscriptional capping", 1086 Globin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886 Polypeptide in eukaryotic initiation factors that crosslinks specifically to

5'-terminal cap in mRNA, 4843 Ribonucleic acid, messenger, mouse

Units of transcription for cytoplasmic RNA in mouse myeloma cells, 4374

Ribonucleic acid, messenger, ovalbumin Ovalbumin gene: A leader sequence in mRNA and DNA sequences at

exon-intron boundaries, 4853 Ribonucleic acid, messenger, plant

Messenger RNA for G1 protein of French bean seeds: Cell-free translation and product characterization, 3196

Ribonucleic acid, messenger, polyadenylylated In vitro transcription of heat-shock-specific RNA from chromatin of

Drosophila melanogaster cells, 759 Light regulation of specific mRNA species in Lenmna gibba L. G-3, 4749

Ribonucleic acid, messenger, procollagen Construction and characterization of 2.5-kilobase procollagen clone, 5417

Ribonucleic acid, messenger, somatotropin Thyroid and glucocorticoid hormones synergistically control growth

hormone mRNA in cultured GH1 cells, 45 Ribonucleic acid, messenger, thyroglobulin


Ribonucleic acid, messenger, viral Biosynthesis of cytoplasmic polyhedrosis virus mRNA:

"Pretranscriptional capping", 1086 Early genes of simian virus 40: Organization and expression, 117 Globin mRNAs are primers for transcription of influenza viral RNA in

vitro, 4886 Inhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732 Nucleotide sequence at junction between coding region of adenovirus 2

hexon messenger RNA and its leader sequence, 5822 Poly(A)-adjacent sequences of mammary tumor virus RNA: Differential

expression in murine mammary cells, 5797 Polyoma virus giant RNAs contain tandem repeats of nucleotide

sequence of entire viral genome, 4754 Polyoma virus T antigelns translated in vitro, 5917 RNA-RNA splicing in vitro in adenovirus 2 mRNA formation, 5344 Rous sarcoma viral RNA translation inhibited by a specific

oligodeoxyribonucleotide, 285 Rous sarcoma virus replication and cell transformation inhibited by a

specific oligodeoxynucleotide, 280 Spliced early mRNAs of simian virus 40, 1274 Splicing of avian sarcoma virus 5'-terminlal genomic sequences onto

viral-specific RNA in infected cells, 1284





04-(5'-Uridylyl)tyrosine is the bond between genome-linked protein and RNA of poliovirus, 4868


Ribonucleic acid, messenger, vitellogenin Primary induction of vitellogenin mRNA in rooster by 17/-estradiol,

1815 Ribonucleic acid, messenger, zein


Ribonucleic acid nucleotidyltransferase Absolute configuration of diastereomers of adenosine


Adenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175 Estrogen receptor binding and transcriptional activity: Role in

stimulation of hyperestrogenism and nuclear bodies, 2781 HeLa cell DNA synthesis: Initiation in a subnuclear system, 5931 Mutant RNA polymerase of Escherichia coli terminates transcription in

strains making defective rho factor, 294 Mutation affecting thermostability of sigma subunit of Escherichia coli

RNA polymerase lies inear dnaG locus at about 66 min on E. coli genetic map, 427

Polynucleotides containing 02- and O4-alkyluridine: Preparation and template activities, 1722

Promoter recognition by phage SPOI-modified RNA polymerase, 1185 RNA metabolism, manganese, and RNA polymerases of zinc-sufficient

and zinc-deficient Euglena gracilis, 4175 RNA polymerase and rho in interact transcription termination: Coupled

ATPase, 4828 Structure of origin of DNA replication of bacteriophage fd, 50 Temperature-sensitive Escherichia coli mutant producing a

temperature-sensitive a subunit of DNA-dependent RNA polymerase, 6177

Template requirements of N4 virion RNA polymerase, 3220 Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6)


Cotranscription of genes for RNA polymerase subunits /3 and /' with genes for ribosomal proteins in Escherichia coli, 3891

Discrete length classes of DNA depend on mode of dehydration, 710 DNA-dependent single-step addition reactions catalyzed by Escherichia

coli RNA polymerase, 1778 Preferential transcription of ovalbumin gene in isolated hen oviduct

nuclei by RNA polymerase B, 686 RNA-dependent RNA polymerase of tobacco plants, 2122 RNA transcribed from DNA at origin of phage fd single strand to

replicative form conversion, 645 Temperature-sensitive RNA polymerase II mutations in Chinese hamster

ovary cells, 405 Ribonucleic acid polymerase

see Ribonucleic acid nucleotidyltransferase Ribonucleic acid purification

Low molecular weight RNA species encoded by a multiple drug resistance plasmid, 3673

Ribonucleic acid replication RNA-dependent RNA polymerase of tobacco plants, 2122

Ribonucleic acid, ribosomal Altered nucleosome structure containing DNA sequences complementary

to 19S and 26S ribosomal RNA in Physarum polycephalum, 1116 Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron


microscopic determination (correction), 2054 Complementary sequences 1700 nucleotides apart form ribonuclease III

cleavage site in Escherichia coli ribosomal precursor RNA, 3593 Complete nucleotide sequence of a 16S ribosomal RNA gene from

Escherichia coli, 4801 Conservation of ribosomal protein binding sites in prokaryotic 16S

RNAs, 2859 Escherichia coli 16S ribosomal RNA: Processing of 5' end, 3598 Free ribosomal RNA genes in Paramecium are tandemly repeated, 3312 Methionine analogs and cell division regulation in Saccharomyces

cerevisiae, 6083 Specific binding of tRNAfMet to 23S rRNA of Escherichia coli, 1071 Structure of psoralen-crosslinked ribosomal RNA from Drosophila

melanogaster, 1642 Transcription patterns of amplified Dytiscus genes coding for ribosomal

RNA after injection into Xenopus oocyte nuclei, 3791 Triphosphate residues at 5' ends of rRNA precursor and 5S RNA from

Dictyostelium discoideum, 740 Triphosphate residues at the 5' ends of rRNA precursor and 5S RNA

from Dictyostelium discoideum (correction), 2539 T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045 Ribonucleic acid structure


RNA sequencing with radioactive chain-terminating ribonucleotides, 5334

Spermine and magnesium ion binding to yeast phenylalanine transfer RNA: Structural analysis, 64

Ribonucleic acid synthesis see also Oligonucleotide synthesis Adenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175

Subject Index 6405

Cloned single repeating units of 5S DNA direct accurate transcription of 5S RNA when injected into Xenopus oocytes, 2849

DNA-dependent single-step addition reactions catalyzed by Escherichia coli RNA polymerase, 1778



Rate of macromolecular synthesis through cell cycle of Saccharomyces cerevisiae, 4384

RNA synthesis-dependent and -independent pathways in stimulation of neurite outgrowth by nerve growth factor, 6059

RNA transcribed from DNA at origin of phage fd single strand to replicative form conversion, 645

Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993 Ribonucleic acid, transfer

Eukaryotic tRNA genes: Specific transcription in Xenopus germinal vesicle extracts, 4819


Molecular field theory of reversible unfolding of biopolymers, 2755 Origin of genetic code: Testable hypothesis based on tRNA structure,

sequence, and kinetic proofreading, 4334 Physical basis for ambiguity in genetic coding interactions, 610 Precursor molecules to individual tRNA species from Bombyx mori

identified, 635 Ribonuclease P: An enzyme with an essential RNA component, 3717 Specific binding of tRNAfMet to 23S rRNA of Escherichia coli, 1071 Spermine and magnesium ion binding to yeast phenylalanine transfer

RNA: Structural analysis, 64 Structure of yeast phenylalanine-tRNA genes: Intervening DNA segment

within region coding for tRNA, 190 Transcription of cloned tRNA gene fragments and subfragments injected

into oocyte nucleus of Xenopus laevis, 1176 Translational control: Recognition of methylated 5' end and an internal

sequence in eukaryotic mRNA by the initiation factor that binds methionyl-tRNAfmet, 650


Ribonucleic acid, transfer, aminoacylated Binding and release of eukaryotic initiation factor eIF-2 and GTP during

protein synthesis initiation, 204 Functional covalent complex between elongation factor Tu and an analog

of lysyl-tRNA, 3075 Pulvomycin, inhibitor of protein biosynthesis preventing ternary

complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA, 5324

Regulation of protein synthesis in rabbit reticulocyte lysates by heme-regulated protein kinase: Inhibition of interaction of Met-tRNAfMet binding factor with another initiation factor in formation of Met-tRNAfMet-40S ribosomal subunit complexes, 745

Specific binding of messenger RNA aind methionyl-tRNAfMet by same initiation factor for eukaryotic protein synthesis, 209

Ribonucleic acid, viral see also Ribonucleic acid, messenger, viral Enzymatic conversion of 5'-phosphate-terminated RNA to 5'-di- and

triphosphate-terminated RNA, 4793 Large Tl oligonucleotides of Moloney letukemia virus missing in env gene

recombinant HIX, are present on intracellular 21S Mololney viral RNA species, 2964



Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366 Nucleotide sequence homology at 3' termini of RNA from vesicular

stomatitis virus and its defective interfering particles, 3225 Potato spindle tuber and citrus exocortis viroids undergo no major

sequence changes during replication in two different hosts, 951 RNA sequences complementary to citrus exocortis viroid in nucleic acid

preparations from infected Gynura aurantiaca, 896 RNase Tl-resistant oligonucleotides derived from genomes of Akv and

MCF murine leukemia viruses: Characterization and mapping, 495 Sequence of a RNA templated by 3'-OH RNA terminus of defective

interfering particles of vesicular stomatitis virus, 4704 Specific RNA sequences and gene products of MC29 avian acute

leukemia virus, 5874 3'-Terminal nucleotide sequence of encephalomyocarditis virus RNA

determined by reverse transcriptase and chain-terminating inhibitors, 4257

Translation of animal virus RNA in cytoplasm of plant cell, 5557 Two regions of adenovirus 2 genome specify families of late polysomal

RNAs containing common sequences, 625 Ribonucleic acid, virus-associated

Adenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175 Ribonucleic acid, yeast

Electron microscopic heteroduplex analysis of "killer" double-stranded RNA species from yeast, 4224

Ribonucleotide reductase Animal cells reversibly permeable to small molecules, 351

Ribosephosphate pyrophosphokinase (EC 2.7.6.1) X-linkage of human phosphoribosylpyrophosphate synthetase, 482

Ribosomal factor Protein synthesis inl rabbit reticulocytes: A ribosomal factor that reverses

inhibition of protein synthesis in heme-deficient lysates, 4858



6406 Subject Index

Ribosome see also Protein, ribosomal; Ribonucleic acid, ribosomal Acceleration of rate of elongation of tyrosine aminotransferase nascent

chains by dibutyryl cyclic AMP, 140 Artemia salina and Escherichia coli ribosome structure compared by

electron microscopy, 2829 Bacteriophage T7 mutations that affect initiation of synthesis of gene 0.3

protein, 2741 Binding sites of ribosomal proteins S4 and S8 on 16S RNA: Electron


microscopic determination (correction), 2054 Computerized multidimensional scaling used to compare


Cycloheximide resistance can be mediated through either ribosomal subunit, 3158

Eukaryotic iinitiation factor 3 localized on native small ribosomal sutbunits, 1389

Nascent peptide as sole attachment of polysomes to membranes in bacteria, 814

Secreted nascent chains: Interaction with surrounding membrane in Bacillus subtilis, 5922


Translational specificity of Bacillus stearothernmophilus ribosomes, 167 T4 RNA ligase used to construct model substrates for a ribosomal RNA

maturation endonuclease, 3045 Ribulosebisphosphate carboxylase (EC 4.1.1.39)

Cell-free synthesis of leaf protein: Identification of apparent precursor of small subunit of ribulose-1,5-bisphosphate carboxylase, 655

Light regulation of specific mRNA species in Lemna gibba L. G-3, 4749 Post-translational transport into intact chloroplasts of precursor to small

subunit of ribulose-1,5-bisphosphate carboxylase, 6110 Ricin

Disulfide bond connecting the chains of ricin, 1096 Disulfide bond connecting the chains of ricin (correction), 4067

Riemannian manifold Incompressible minimal surfaces, three-dimensional manifolds with

nonnegative scalar curvature, and positive mass conjecture in general relativity, 2567

Riemannian symmetric space Unstable cohomology classes of SLn (Z), 43

Riemann mapping function Asymptotic representation of conformal maps of strip domains without

boundary regularity, 2082 Rifampicin

Mutant RNA polymerase of Escherichia coli terminates transcription in strains making defective rho factor, 294

Rod, vertebrate Opposing effects of calcium and barium in vertebrate rod

photoreceptors, 1587 Responses to light of solitary rod photoreceptors isolated from tiger

salamander retina, 3507 Rogers-Ramanujan identity

Lie algebras and classical partition identities, 578 Rooster

Primary induction of vitellogenin mRNA in rooster by 17/-estradiol, 1815

Rotational pole Global problems of geophysical fluid dynamics (Review), 34

Rotational symmetry Rotational symmetry: Effect on colored lattices, 5751

Rutamycin Cytoplasmic inheritance of rutamycin resistance in mouse fibroblasts,

324

Saccharomyces cerevisiae Chromosome mapping of CYC7 gene determining yeast iso-2-cytochrome

c: Structural and regulatory regions, 1437 Electron microscopic heteroduplex analysis of "killer" double-stranded

RNA species from yeast, 4224 Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)

controlled by a bacterial insertion element (IS2), 6172 Mating factor os: Inactivation and chemical alteration by cells and

spheroplasts of yeast, 1304 Methionine analogs and cell division regulation in Saccharomyces

cerevisiae, 6083 Rate of macromolecular synthesis through cell cycle of Saccharomyces

cerevisiae, 4384 Regulation of galactose pathway in Saccharomyces cerevisiae: Induction


Spontaneous mitotic recombination occurs at the two-strand stage, 4436 Transformation of yeast, 1929 Tubulin from the yeast Saccharomyces cerevisiae identified, 4962

Salamander see also Ambystoma trigrinum Sound transmission in salamander ear, 529

Salicylate see also Acetylsalicylic acid , Transposition of plasmid DNA segments specifying hydrocarbon

degradation and their expression in various microorganisms, 3109 Salmo gairdneri

Olfaction: Binding specificity of radioactively labeled stimuli to an isolated olfactory preparation fromn rainbow trout (Salmo gairdneri), 4679


Salmo irideus Macromolecular transducer as illustrated by trout hemoglobin IV, 4310

Salmonella test Cyclopenta[c,d]pyrene: A highly mutagenic polycyclic aromatic

hydrocarbon, 1667 Salmonella typhimurium


Duplicate tuf genes in enteric bacteria: Direct demonstration, 3104 Membrane protein identified as a histidine transport component in

Salmonella typhimurium, 5447 Potentiation, desensitization, and inversion of response in bacterial

sensing of chemical stimuli, 2820 Protein methylesterase involved in bacterial sensing, 3659 Quantitative forward mutation assay in S'lmonella typhimurium using


Salmonella typhimurium, 4465 Salting out


Sanfilippo syndrome Sanfilippo syndrome type C: Deficiency of acetyl-CoA:a-glucosaminide

N-acetyltransferase in skin fibroblasts, 5185 Saponin

Ultrastructural antibody localization of o2-macroglobulin in membrane-limited vesicles in cultured cells, 4359

Sarcoma Tumor antigens enhance tumor growth in vivo by interacting with a

radiosensitive (suppressor?) cell population, 436 Sarcoma virus, avian

Amino-terminal amino acid sequence of major structural polypeptides of avian retroviruses: Sequence homology between reticuloendotheliosis virus p30 and p30s of mammalian retroviruses, 2708

Envelope glycoprotein of avian sarcoma virus: Immunogenicity, 1962 Nucleotide sequences related to transforming gene of avian sarcoma

virus are present in DNA of uninfected vertebrates, 4102 Polypeptide encoded by avian sarcoma virus src gene: Identification,

1567 Protein kinase activity associated with avian sarcoma virus src gene

product, 2021 Recombination between viral and cellular sequences generates

transforming sarcoma virus, 5812 Splicing of avian sarcoma virus 5'-terminal genomic sequences onto

viral-specific RNA in infected cells, 1284 Sarcoma virus, feline

Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein with feline oncornavirus-associated cell membrane antigen (FOCMA) activity, 1505

Sarcoma virus, Moloney ml Moloney sarcoma virus pP60gag gene order: Unique peptides in

carboxy terminus of the polyprotein, 4694 "Sarcoma-specific" region of Moloney murine sarcoma virus 124, 2694

Sarcoma virus, murine Growth factors from murine sarcoma virus-transformed cells, 4001 Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647 Sarcoma virus, rat

Isolation of stable rat sarcoma viruses in vitro, 2972 Sarcoma virus, Rous

Assay for early cytoplasmic effects of src gene product of Rous sarcoma virus, 2750

Detection of early surface change during oncogenic transformation, 3703 DNA synthesis induced in terminally differentiated myotubes by

activation of src gene of Rous sarcoma virus, 5501 Infection with paramyxoviruses stimulates synthesis of cellular



Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366 Processing of 60,000-dalton sarc gene protein synthesized by cell-free

translation, 4399 Reversion of transformed glycolysis to normal by inhibition of protein


Rous sarcoma viral RNA translation inhibited by a specific oligodeoxyribonucleotide, 285


Transfer of duck cell DNA sequences to nucleus of 3T3 cells by Rous sarcoma virus, 4252

Sarcoplasmic reticulum Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329 Membrane sites in glycerinated chicken skeletal muscle fibers:


Sarcoplasmic reticulum CaI+ATPase: Rotational motion, 5488 Satellite system

Stability in dynamical astronomy, 5743 Saxitoxin

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218 Scalar curvature, nonnegative

Incompressible minimal surfaces, three-dimensional manifolds with nonnegative scalar curvature, and positive mass conjecture in general relativity, 2567




Scald disease Rhynchosporoside, a host-selective toxin produced by Rhynchosporium

secalis, the causal agent of scald disease of barley, 4339 Schiff base

Internal charge transfer in proteins to Schiff bases of their lysine side chains, 3548

Secondary protein-chromophore interactions at Schiff base linkage in bacteriorhodopsin: Molecular mechanism for proton pumping, 4642

Schistosoma mansoni Immunodiagnosis of infection with Schistosoma mansoni:


Schistosomiasis Immunodiagnosis of infection with Schistosoma mansoni:


Schizophrenia [lS8FFluoro-dopa, an analogue of dopa, and its use in direct external


Scrapie Creutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsters

with reference to clinical syndromes and strains of agent, 3432 Unusual resistance to ionizing radiation of the viruses of kuru,

Creutzfeldt-Jakob disease, and scrapie, 6268 Scrapie virus


Sea urchin see Arbacia punctulata; Lytechinus pictus; Strongylocentrotus

purpuratus Secretory vesicle

Lactose and major milk proteins are present in secretory vesicle-rich fractions from lactatiing mammary gland, 5020

Selenium dioxide Direct C-1 hydroxylation of vitamin D compounds: Preparation of

loY-hydroxyvitamin D3, 1(,25-dihydroxyvitamin D3, and l.(-hydroxyvitamin D2, 2080

Semiconductivity Electronic properties of some protein--methylglyoxal complexes, 315

Semisimple Lie group see also Algebra, Lie Algebraic construction and classification of Harish-Chandra modules,

1063 Existence of a nonarithmetic lattice in SU (2,1), 3029

Semliki Forest virus Human (HLA-A and HLA-B) and murine (H-2K and H-2D)


Protein micelles formed from amphiphilic membrane proteins, 5306 Sendai virus

Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells, 5145

Fusion protein of Sendai virus purified: NH2-terminal sequence generated during precursor activation, 2737

Protein micelles formed from amphiphilic membrane proteins, 5306 Spectrin participates in Sendai virus-induced fusion of human

erythrocyte ghosts, 1740 S1 endonuclease

see also Nuclease S1 Spliced early mRNAs of simian virus 40, 1274

L-Serine Serine-borate complex as transition-state inhibitor of Y-glutamyl

transpeptidase, 4806 Specific phosphorylation at serine-283 of ov tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588 D-Serine deaminase

see D-Serine dehydratase D-Serine dehydratase (EC 4.2.1.14)

Positive control of D-serine deaminase synthesis in uitro, 1695 Serine protease

see also Protease Immunofluorescent localization of a serine protease in rat small

intestine, 2785 Major serine protease in rat skeletal muscle: Its mast cell origin, 5311 Nerve growth factor: A protease that can activate plasminogen, 5497

Serotonin see also Receptor, serotonin Neurotransmitter modulation, phosphodiesterase inhibitor effects, and

cyclic AMP correlates of afterdischarge in peptidergic neurites, 5200 Presynaptic modulation of voltage-dependent Ca2+ current: Mechanism

for behavioral sensitization in Aplysia californica, 3512 Serotonin and substance P coexist in neurons of rat's central nervous

system, 1582 Systemic administration of /-endorphin: Potent hypotensive effect

involving a serotonergic pathway, 6240 Serum

Adipose conversion of 3T3 cells depends on a serum factor, 6107 Coordinate control of 3T3 cell proliferation by platelet-derived growth

factor and plasma components, 2810 Glucose binding and transport proteinrls extracted from fast-growing

chicken fibroblasts, 5427 Lipid A and endotoxin in serum determined by mass spectroscopy, 3993 Magnesium reverses inhibitory effects of calcium deprivation on

coordinate response of 3T3 cells to serum, 4379 Nerve growth factor in mouse and rat serum: Correlation between

bioassay and radioimmunoassay determinations, 4042

Subject Index 6407


Spin assay for reserve bilirubin loading capacity of human serum, 1542 Serum deprivation

Increased incorporation of adenosine into adenine nucleotide pools in serum-deprived mammalian cells, 1145

Serum, human Cholesterol biosynthesis in HeLa S3G cells regulated by serum


Serum substance Murine Ss protein: Ss protein is functionally the fourth component of

complement, 2424 Sex factor


Sheep Hemoglobin switching in sheep: Only the y gene is in active

conformation in fetal liver but all the /f and y genes are in active conformation in bone marrow, 5884

Shigella dysenteriae Naturally occurring promoter down mutation: Nucleotide sequence of

trp promoter/operator/leader region of Shigella dysenteriae 16, 5580 Shock, circulatory

Histamine Hl- and H2-receptor antagonists: Beneficial and detrimental actions in circulatory shock, 2941

Sialic acid Autosomal locus regulates inverse relationship between sialic acid



Membrane sialic acid regulates 1IH-dependent decay-dissociation of amplification C3 convertase of alternative complement pathway, 1971

Sialyltransferase (EC 2.4.99.1) Differences in isoelectric focusing patterns of -y-glutamyl transpeptidase

from normal and cancerous rat mammary tissue, 1750 Siderophore

Siderophore electrochemistry: Relation to intracellular iron release mechanism, 3551

Signal hypothesis Escherichia coli mutant with amino acid alteration within signal

sequence of outer membrane prolipoprotein, 4891 Signal peptidase


Signal sequence Mutations altering cellular localization of phage X receptor, an

Escherichia coli outer membrane protein, 5802 Silane, iodotrimethyl-

Silane/iodine-based cleavage of esters and ethers under neutral conditions, 4

Silane, phenyltrimethyl- Silane/iodine-based cleavage of esters and ethers under neutral

conditions, 4 Silkmoth

see Antheraea polyphemus Simian virus 40

BK virus DNA: Cleavage map and sequence analysis, 2150 Carcinogens enhance survival of UV-irradiated simian virus 40 in treated

monkey kidney cells: Induction of a recovery pathway? 346 Chromosomal assignment for a simian virus 40 integration site in human

cells, 4460 Clonal human placental cells established synthesizing human

choriogonadotropin, 1854 Differences in behavior and prognosis between leukemic and




DNA supercoiling by Xenopus laevis oocyte extracts: Requirement for a nutclear factor, 4873

Early genes of simian virus 40: Organization and expression, 117 Human placental cells transformed by tsA mutants of simian virus 40:

Model system for study of placental functions, 1409 Large and small tumor antigens from simian virus 40 have identical

amino termini mapping at 0.65 map units, 2165 Local mutagenesis: Method for generating viral mutants with base

substitutions in preselected regions of viral genome, 2170 Local mutagenesis: Method for generating viral mutants with base

substitutions in preselected regions of viral genome (correction), 4596 Modification of DNA by the benz[a]pyrene metabolite diol-epoxide

r-7,t -8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a ] pyrene, 415 Mouse preimplantation embryos infected with simian virus 40 and

polyoma virus, 999 New region of simian virus 40 genome required for efficient viral

transformation, 2473 Nucleotide sequence of simian virus 40 small-t gene, 2160 Nucleotide sequences around o(rigin of DNA replication similar in mouse

polyoma virus and simian virus 40, 162 Origin of DNA replication in papovavirus chromatin is recognized by

endogenous endonuclease, 5964 Primate papovavirus tumor antigens: Commonl methionine-tryptic

peptides near amino-terminal end, 1131



6408 Subject Index

Purified simian virus 40 T antigen proteins: Biological activity, 1279 Recognition site of Escherichia coli B restriction enzyme on oXsB1 and

simian virus 40 DNAs: Interrupted sequence, 2271 Role of Na+ in a-aminoisobutyric acid uptake by membrane vesicles

from mouse fibroblasts transformed by simian virus 40, 2329 Simian virus 40 A gene function: DNA content analysis of Chinese



Somatic cell hybrids producing antibodies specific for tumor antigen of simian virus 40, 2320

Species-specific cellular DNA-binding proteins expressed in mouse cells transformed by chemical carcinogens, 1647

Spliced early mRNAs of simian virus 40, 1274 Transduction of a bacterial gene into mammalian cells, 2117 Tumor-specific transplantation antigen: Ad2+ndi hybrid virus used to


Viable deletion mutants in simian virus 40 early region, 4455 Sindbis virus


Sleeping sickness Trypanocidal factor identified in normal human serum: High density

lipoprotein, 3450 Sleep-promoting factor

Sleep-promoting factor S: Purification and properties, 5235 Social dynamics

Social dynamics and quantifying of social forces, 4633 Sodium

Acetylcholine-receptor-mediated ion flux in electroplax membrane microsacs (vesicles): Change in mechanism produced by asymmetrical distribution of sodium and potassium ions, 1703

Aldosterone secretion regulated by the renin-angiotensin system during sodiumn restriction in rats, 4057


Energetics of sodium transport in toad urinary bladder, 4591 In vitro differentiation of a fast Na+ conductance in embryonic heart cell

aggregates, 2776 Role of Na+ in o(-aminoisobutyric acid uptake by membrane vesicles

from mouse fibroblasts transformed by simian virus 40, 2329 Serum stimulates Na+,K+ pump in quiescent fibroblasts by increasing

Na+ entry, 5560 Sodium-dependent amino acid transport by cultured hamster cells:

Membrane vesicles retain transport changes due to glucose starvation and cycloheximide, 5048



Transmitter release: Changes induced by ion-containing liposomes, 5214 Solar motion

Kinematics of faint white dwarfs, 4640 Solid

One-phase Stefain problem and porous medium diffusion equation: Continuity of the solution in n space dimensions, 2084

N-Soliton solution N-soliton solution of the Benjamin-Ono equation, 3562

Solution One-phase Stefan problem and porous medium diffusion equation:

Continuity of the solution in n space dimensions, 2084 Solvent exclusion

Macromolecular shape and surface maps by solvent exclusion, 303 Somatostatin

Somatostatin: Conformationally restricted bicyclic analogs, 2636 Somatostatin inhibits release of thyrotropin releasing factor from organ

cultures of rat hypothalamus, 4509 Thyrotropin-releasing hormone: High concentration in pancreatic islets,

4265 Somatotropin

Accumulation of a slowly dissociable peptide hormone binding component by isolated target cells, 672

Growth hormone modulation of murine erythroleukemia cell growth in vitro, 3437



Pituitary somatotrophs contain [Metlenkephalin-like immunoreactivity, 6134

Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294 Thyroid and glucocorticoid hormones synergistically control growth

hormone mRNA in cultured GH1 cells, 45 Sorbose


SOS function Early events and mechanisms in induction of bacterial SOS functions:

Analysis of phage repressor inactivation process in vivo, 1657 Escherichia coli recA gene product inactivates phage X repressor, 4714



Sound transmission Sound transmission in salamander ear, 529

Soybean see Glycine max

Space-time Symmetry and causality properties of physical fields, 1609

Spatiotemporal pattern formation Spatiotemporal pattern formation in thin layers and membranes: Critical

focal size, 4313 Spectrin


Spectrin participates in Sendai virus-induced fusion of human erythrocyte ghosts, 1740

Spectrophotometry Chemical composition of gaseous nebula NGC 6302, 1

Spectropolarimetry Ten-nanometer filaments of hamster BHK-21 cells and epidermal

keratin filaments have similar structures, 6098 Sperm

Egg surface glycoprotein receptor for sea urchin sperm bindin, 881 Phospholipid vesicle stimulation of proacrosin activation, 149 Potent inhibition of dyinein adenosinetriphosphatase and of motility of

cilia and sperm flagella by vanadate, 2220 Stimulation of in vitro activation and the acrosome reaction of hamster

spertnatozoa by catecholamines, 4954 Spermine

Spermine and magnesium ion binding to yeast phenylalanine transfer RNA: Structural analysis, 64

Spinal cord y-Aminobutyric acid receptors visualized in spinal cord cultures by

[3H]muscimol autoradiography, 6281 Spin label


Electron spin resonance studies on interaction of complement proteins with erythrocyte membranes, 4930

Erythrocyte membrane abnormalities in Duchenne muscular dystrophy monitored by saturation transfer electroln paramagnetic resonance spectroscopy, 838



Oxygen binding by hemoglobin, 5462 Photochemical technique for measuring lateral diffusioln of spin-labeled

phospholipids in membranes, 4661 Sarcoplasmic reticulum Ca2+ATPase: Rotational motion, 5488 Specific antibody and Clq binding to hapten-sensitized lipid vesicles


hapten-sensitized lipid vesicles, 1515 Spin assay for reserve bilirubin loading capacity of human serum, 1542 Spin labeling of a cysteine residue of Escherichia coli outer membrane

lipoprotein in its membrane environment, 127 Spiperone

s-Adrenergic receptors in caudate nucleus selectively labeled by [3H]dihydroergocryptine in presence of spiperone-blocked dopamine receptors, 2249

Splanchnic glucose exchange Influence of hyperinsulinemia, hyperglycemia, and the route of glucose

administration on splanchnic glucose exchange, 5173 Spleen

see also Cell, spleen Gaucher disease: Isolation and comparison of normal and mutant

glucocerebrosidase from human spleen tissue, 3970 Residual adenosine deaminating activity in spleen of a patient with

combined immunodeficiency disease and adenosine deaminase deficiency, 446

Spleen endonuclease (EC 3.1.4.7) Compact oligomers and nucleosome phasing, 3583

Spleen focus-forming virus Changes in genome composition of Friend virus complex in


Spleen necrosis virus Sites of integration of reticuloendotheliosis virus DNA in chicken DNA,

3372 Spongiform virus encephalopathy

see also Subacute spongiform encephalopathy Creutzfeldt-Jakob disease: Interspecies transmission to Syrian hamsters

with reference to clinical syndromes and strains of agent, 3432 Stability law

Law of perceptual stability: Well-definedness and validity, 2535 Stability in dynamical astronomy, 5743

Stability of local rings Stability of local rings of dimension 2, 4085

Star Kinematics of faint white dwarfs, 4640

Starvation Protein degradation in diabetes and starvation, 2093

Statistical mechanics Nonequilibrium entropy, Lyapounov variables, and ergodic properties of

classical systems, 1627




Statistics Adaptive design in regression and control, 586 Chronometric cosmology: Redshift--magnitude relation for quasi-stellar

objects, 535 Limit theorems for weighted sums and stochastic approximation

processes, 1068 Statistics of self-avoiding walks confined to strips and capillaries, 2069

Steady state Allosteric regulation of monocyclic interconvertible enzyme cascade




Stellar system Stability in dynamical astronomy, 5743

Steroid Selective complexing of "nuclear" 5S estradiol receptor by serum

component, 5S-CA, 2664 Specific regulation by steroid hormones of amount of type I cyclic

AMP-dependent protein kinase holoenzyme, 223 Steroid hormones mediate reversible phenotypic transition between

transformed and untransformed states in mouse fibroblasts, 2805 Steroidogenesis




Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells, 99

Steroid pyrone Lucibufagins: Defensive steroids from fireflies Photinus ignitus and P.

marginellus (Coleoptera: Lampyridae), 905 Sterol

Sterol requirement of Mycoplasma capricolum, 4107 Stochastic approximation

Adaptive design in regression and control, 586 Does environmental variability limit niche overlap? 5085 Limit theorems for weighted sums and stochastic approximation

processes, 1068 Stochastic process

Genetic variability: Theoretical study assuming stepwise production of neutral and very slightly deleterious mutations, 919


Stochastic theory Stochastic theory of ligand migration in biomolecules, 26

Streptococcus faecalis "Conjugal" transfer of plasmid DNA among oral streptococci, 3484 Induced cell aggregation and mating in Streptococcus faecalis: Evidence

for bacterial sex pheromone, 3479 Streptomycin



Striatum High molecular weight opioid-containing proteins in striatum, 4021 Ontogenetic development of kainate neurotoxicity: Correlates with

glutamatergic innervation, 2025 Strongylocentrotus purpuratus

Egg surface glycoprotein receptor for sea urchin sperm bindin, 881 Hydrogen peroxide production, chemiluminescence, and respiratory


Translocation of DNA sequences during sea urchin embryogenesis, 5627 Subacute spongiform encephalopathy


Submaxillary gland Location on chromosome 1 of Rnr, a gene that regulates renin in

submaxillary gland of mouse, 5623 Substance P



Succinate-cytochrome c reductase see Succinate dehydrogenase

Succinate dehydrogenase (EC 1.3.99.1) Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339 Sugar pucker geometry

Sugar pucker geometries at intercalation site of propidium diiodide into miniature RNA and DNA duplexes in solution, 2553

Sulfur Tetrakis(acetoxymercuri)methane: Polymetallic reagent for labeling

sulfur in nucleic acids, 1181 Superoxide dismutase (EC 1.15.1.1)

Photodestruction of pheomelanin: Role of oxygen, 5395 Symbiont


Subject Index 6409

Symbiosis Mutant strains of clover rhizobium (Rhizobium trifolii) that form

nodules on soybean (Glycine max), 2343 Symbolic calculus

On positivity of pseudo-differential operators, 4673 Symmetry

Colored lattices, 5264 Symplectic structure

Yang-Mills equations in physical space: General properties, 4638 Synapse

Acetylcholine release from neuroblastoma X glioma hybrid cells: Regulation, 1314

Channel open time and metabolic stability of synaptic and extrasynaptic acetylcholine receptors on cultured chick myotubes, 520

Electrotonic synapses uncoupled by calcium, 4577 Genetic dissection of short-term and long-term facilitation at Drosophila

neuromuscular junction, 515 Synapses involving auditory nerve fibers in primate cochlea, 4582 Synapse turnover: Mechanism for acquiring synaptic specificity, 2281

Synaptic vesicle Release of neurotransmitters and depletion of synaptic vesicles in

cerebral cortex slices by (a-latrotoxin from black widow spider venom, 4016

Synaptogenesis Electrophysiological analysis of reinnervation of transplants in anterior

chamber of eye by autonomic ground plexus of iris, 1009 Factor from neurons increases the number of acetylcholine receptor

aggregates on cultured muscle cells, 4011 Membrane particle aggregates in innervated and noninnervated cultures

of Xenopus embryonic muscle cells, 500 Olfactory axons and synapse formation regenerated in forebrain after

bulbectomy in neonatal mice, 5230 Thy- -differentiation alloantigen associated with synaptic complexes

isolated from mouse brain, 3283 Synaptosome

--Aminobutyric acid transport modulated in nerve endings: Role of extracellular y-aminobutyric acid and of cationic fluxes, 2981

Cholecystokinin-like immunoreactivity localized in isolated nerve terminals, 6324

Myoinositol and phosphatidylinositol metabolism in synaptosomes from galactose-fed rats, 4568

Synergy Proliferative response to alloantigen amplified by factor present in

extract of syngeneic thymic lymphoid cells, 4474 Synovial fluid


Systemic lupus erythematosus Failure of autologous mixed lymphocyte reactions between T and non-T

cells in patients with systemic lupus erythematosus, 3464 Neurocytotoxic antibodies in serum of patients with systemic lupus

erythematosus, 3965 Type C RNA virus-specific antibody in human systemic lupus

erythematosus demonstrated by enzymoimmunoassay, 2463

Taenia coli Contraction of detergent-treated smooth muscle, 3527

Tangier disease Trypanocidal factor identified in normal human serum: High density

lipoprotein, 3450 T antigen

see Antigen, tumor Teleogryllus oceanicus

Steering responses of flying crickets to sound and ultrasound: Mate attraction and predator avoidance, 4052

Teratocarcinoma Carbohydrate structure and cell differentiation: Fucosyl-glycopeptides

isolated from embryonal carcinoma cells, 2315 Chimeric mice derived from human-mouse hybrid cells, 1914 Embryonal carcinoma cells: Growth in serum-free medium, 1844 High molecular weight cell surface glycoprotein (LETS protein)





Teratocarcinoma cells as vehicles for introducing specific mutant mitochondrial genes into mice, 5113


Teratocarcinomas: Somatic cell origin, 2834 Terbium

Fluorescence energy transfer in the rapid-diffusion limit, 5746 Territoriality

Alternative mating strategies in digger wasp Philanthus zebratus Cresson, 1901

Testis see also Membrane, testis Photoperiodic regulation of hamster testis: Dependence on circadian

rhythms, 1034 Tetracarbonyl compound

Bond angles in transition metal tetracarbonyl compounds: Test of theory of hybrid bond orbitals, 569



6410 Subject Index

Tetracycline Temperature-sensitive Escherichia coli mutant producing a

temperature-sensitive eo subunit of DNA-dependent RNA polymerase, 6177

12-O-Tetradecanoyl phorbol-13 acetate 2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-O-tetradecanoyl phorbol-13-acetate, 5422 Tumor promoter induces sister chromatid exchanges: Relevance to

mechanisms of carcinogenesis, 6149 Tetrahydrofolate dehydrogenase (EC 1.5.1.3)



Tetrahymena Tetrahymena macronuclear DNA: Viscoelastic studies, 5062

Tetrahymena thermophila Cycloheximide resistance can be mediated through either ribosomal

subunit, 3158 Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,

glucose, and epinephrine, 1810 Temperature-sensitive mutants in Tetrahymena: Mass isolation and

fertility testing, 3355 Tetrakis(acetoxymercuri)methane


Tetrodotoxin Tetrodotoxin-binding component associated with voltage-sensitive

sodium channel from Electrophorus electricus electroplax membranes: Purification, 2606

Thalassemia Changes in restricted human cellular DNA fragments containing globin

gene sequences in thalassemias and related disorders, 1222 Duplicated human a globin genes lie close together in cellular DNA, 5950 Proteolytic activity in erythrocyte precursors, 3427 Separation of younger red cells with improved survival in vivo: Approach

to chronic transfusion therapy, 3474 Theophylline


Thermal tolerance Evolutionary adaptation of membranes to temperature, 2040

Thermal transition Phospholipid bilayers in the transition zone: Nanosecond relaxation

processes, 3011 Thermodynamics

Anlesthetics and pressure: Effect on thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes, 4906

Derivation of linear irreversible thermodynamics for classical fluids, 1632 Hysteresis effects of C1H4 and C2H4 in regions of solid-phase transitions,

4664 Interaction of methotrexate, folates, and pyridine nucleotides with


Reciprocal effects in human hemoglobin: Direct measurement of dimer-tetramer association constant at partial oxygen saturation, 5493

Self-association of hemoglobin OSH chains is linked to oxygenation, 311 Thermogenesis


Thermophilic bacterium PS3 Membrane moiety of the H+-ATPase complex resolved into two kinds of

subunits, 4219 Thermoregulation


Thermotropic behavior Anesthetics and pressure: Effect on thermotropic behavior of

multilamellar dipalmitoylphosphatidylcholine liposomes, 4906 Thiol

Production of autoinhibitory factors by mouse lymphoma cells in vitro and its relationship to thiol dependence, 1849

Thioredoxin Thioredoxin induced by bacteriophage T4: Three-dimensional structure,

5827 Thiostrepton i

Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA, 5993 Three squares theorem

Pompeiu's problem on discrete space, 3555 Thrombin

see also Prothrombin Ca2+-related regulatory function of fibrinogen, 4234 Dexamethasone modulates binding and action of epidermal growth

factor in serum-free cell culture, 1882 Ionophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Thrombosis

Fibronectin: Identification, localization, and role in cultured bovine endothelial cells, 3273

Thromboxane Fatty acid cyclooxygenase from human aorta: Sensitivity to acetylation

by aspirin, 5181 Ionophore A23187- and thrombin-induced platelet aggregation:

Independence from cycloxygenase products, 818 Thymic hormone



Thymidine kinase Herpes simplex virus: Ultraviolet reactivation is mutagenic and inducible

in mammalian cells, 2378 Human placental cells transformed by tsA mutants of simian virus 40:

Model system for study of placental functions, 1409 Thymidine kinase (EC 2.7.1.75)

Chimeric mice derived from human-mouse hybrid cells, 1914 Thymidine kinase and galactokinase genes: Cotransfer by

chromosome-mediated gene transfer, 914 Thymidylate synthase (EC 2.1.1.45)


Thymidylate synthetase Mechanism of integrating foreign DNA during transformation of

Bacillus subtilis, 3664 Two thymidylate synthetases in Bacillus subtilis, 1194

Thymine Uracil incorporation into nascent DNA of thymine-requiring mutant of

Bacillus subtilis 168, 2195 Thymosin al

Translation of mRNA from calf thymus in wheat germ system: Evidence for precursor of thymosin al, 6007

Thymus Major histocompatibility complex-linked immune-responsiveness is

acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice, 2439

T-cell helper function: Regeneration in zinc-deficient adult mice, 5660 Thymic hormone-like restoration by human prealbumin of azathioprine

sensitivity of spleen cells from thymectomized mice, 823 Translation of mRNA from calf thymus in wheat germ system: Evidence

for precursor of thymosin (1i, 6007 Thyroglobulin


Thyroid Abnormal cellular localization of thyroglobulin mRNA associated with

hereditary congenital goiter and thyroglobulin deficiency, 74 Enzymatic defect in obese (ob/ob) mouse: Loss of thyroid-induced

sodium- and potassium-dependent adenosinetriphosphatase, 477 Oligosaccharides containing glucose and mannose in glycoproteins of

thyroid gland, 1162 Thyroid phospholipids: Effect on interaction of thyrotropin with thyroid

membranes, 5301 Thyroliberin

Prolactin and somatotropin mRNAs regulated by thyroliberin, 1294 Somatostatin inhibits release of thyrotropin releasing factor from organ

cultures of rat hypothalamus, 4509 Thyrotropin-releasing hormone: High concentration in pancreatic islets,

4265 Thyrotropin


Thyrotropin-releasing hormone see Thyroliberin

Thyroxine Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate

synthetase I in tadpole liver, 5339 Thyroid hormones control lysosomal enzyme activities in liver and

skeletal muscle, 1369 Time-lapse photography

Kinetics of desynchronization and distribution of generation times in synchronized cell populations, 4404

Tissue factor Factor IX activated by reaction product of tissue factor and Factor VII:

Additional pathway for initiating blood coagulation (correction), 2539 Tobacco

see Nicotiana tabacum Tobacco mosaic virus

Kinetics of biphasic reconsitution of tobacco mosaic virus in Vitro, 1727 RNA-dependent RNA polymerase of tobacco plants, 2122

Tobacco necrosis virus RNA-dependent RNA polymerase of tobacco plants, 2122

Togavirus Amino-terminal sequence analysis of structural proteins of Sindbis virus,

2722 Toluene

Electrophilic and free radical nitrationl of benzene and toluene with various nitrating agents, 1045

Transposition of plasmid DNA segments specifying hydrocarbon degradation and their expression in various microorganisms, 3109


Torpedo californica Acetylcholine receptor localized in excitable membrane from electric

organ of Torpedo: Exposure of receptor antigenlic sites on both sides of membrane, 2497

Immunization of rats with polypeptide chains from torpedo acetylcholine receptor causes autoimmune response to receptors in rat muscle, 769

Ligand-dependent conformational changes in trypsin-solubilized and in membrane particle-conlstrained acetylcholinesterase: Functional consequences, 3613

Specific immunosuppression of experimental autoimmune myasthenia gravis by denatured acetylcholine receptor, 4006





Torpedo marmorata Distinct protein compolnents from Torpedo marmorata membranes carry

acetylcholine receptor site and binding site for local allesthetics and histrionicotoxin, 510


Tortula ruralis Messenger RNA is conserved during dryinlg of drought-tolerant moss

Tortula ruralis, 842 Toxin

see also specific toxins Toxin A


Toxin, cholera ADP-ribosylation of membrane proteins catalyzed by cholera toxin:

Basis of activation of adenylate cyclase, 3050 Affinity filters, approach to isolation of tox mutants of Vibrio cholerae,

941 Avian erythrocyte protein isolated possessing ADP-ribosyltransferase

activity and capable of activating adenylate cyclase, 3621 Cholera toxin action: Covalent modification of guanyl nucleotide-binding

protein of adenylate cyclase system, 2669 Cholera toxin-activated adenylate cyclase: Reconstitution, 3113 Cholera toxin: Endocytosis into neuronal GERL, 2815 Human chorionic gonadotropin: Interaction with membrane components

of rat testes, 764 Toxin, diphtheria

Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with fragment A from diphtheria toxin, 5319

Diphtheria toxin has properties of a lectin, 261 Mutants of human diploid fibroblasts resistant to diphtheria toxin:

Isolation and characterization, 3337 Pseudomonas aeruginosa exoenzyme S: An adenosine diphosphate

ribosyltransferase distinct from toxin A, 3211 Toxin, scorpion

Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218 Tracer efflux

Receptor-controlled tracer effltx from sealed membrane fragments: Kinetic analysis, 3756

Transcription Adenovirus DNA-directed transcription of 5.5S RNA in vitro, 2175 Biosynthesis of cytoplasmic polyhedrosis virus mRNA:

"Pretranscriptional capping", 1086 Butyrate suppression of histone deacetylation leads to accumulation of



cro protein of bacteriophage X: Mechanism of action, 1783 DNA sequence from histidine operon control region: Seven histidine

codons in a row, 4281 Gene adjacent to satellite DNA in Drosophila melanogaster, 5898 Genetic regulation of galactokinase in Tetrahymena by cyclic AMP,

glucose, and epinephrine, 1810 In vitro transcription of heat-shock-specific RNA from chromatin of

Drosophila melanogaster cells, 759 Minichromosome from BK virus as template for transcription in vitro,

1126 Mutant RNA polymerase of Escherichia coli terminates transcription in

strains making defective rho factor, 294 Mutation affecting thermostability of sigma subunit of Escherichia coli


N gene protein of bacteriophage A identified, 2225 Nucleotide sequence of attenuator region of histidine operon of

Escherichia coli K-12, 4276 Nucleotide sequence of leader region of phenylalanine operon of

Escherichia coli, 4271 Preferential transcription of ovalbumin gene in isolated hen oviduct

nuclei by RNA polymerase B, 686 Regulation of transcription of late genes of bacteriophage T7, 804 Spliced early mRNAs of simian virus 40, 1274 Transcription of a defective polyoma virus genome, 69 Transcription of cloned tRNA gene fragments and subfragments injected

into oocyte nucleus of Xenopus laevis, 1176 Triphosphate residues at 5' ends of rRNA precursor and 5S RNA from

Dictyostelium discoideum, 740 Triphosphate residues at the 5' ends of rRNA precursor and 5S RNA

from Dictvostelium discoideum (correction), 2539 Units of transcription for cytoplasmic RNA in mouse myeloma cells,

4374 Variable and constant regions are separated in 10-kbase transcription

unit coding for immunoglobulin K light chains, 6044 Transcription termination

RNA polymerase and rho in interact transcription termination: Coupled' ATPase,4828




Transducer, macromolecular Macromolecular transducer as illustrated by trout hemoglobin IV, 4310

Transduction Transduction of a bacterial gene into mammalian cells, 2117

Subject Index 6411

Transferrin Plasma radioiron kinetics in man: Explanation for effect of plasma iron

concentration, 1559 Transformation


Transformation of yeast, 1929 Transformation of cells, chemical

Neoplastic transformation in vitro: Progressive nature, 3761 Neoplastic transformation of human diploid fibroblast cells by chemical

carcinogens, 1334 Species-specific cellular DNA-binding proteins expressed in mouse cells

transformed by chemical carcinogens, 1647 Transformation of cells, viral

Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells, 2488

Binding to chromosomes of herpes simplex-related antigens in biochemically transformed cells, 3288

Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components, 3974

Chromosomal assignment for a simian virus 40 integration site in human cells, 4460

Clonal human placental cells established synthesizing human choriogonadotropin, 1854



Detection of early surface change during oncogenic transformation, 3703 Differences in behavior and prognosis between leukemic and



DNA synthesis induced in terminally differentiated myotubes by activation of src gene of Rous sarcoma virus, 5501


Escherichia coli plasmid bearing functional gene G of bacteriophage oX174: Construction and characterization, 774

Expression of simian virus 40 early genes in transformed rat cells is correlated with maintenance of transformed phenotype, 4987


Generation of oncogenic type C viruses: Rapidly leukemogenic viruses derived from C3H mouse cells in vivo and in vitro, 2468

Growth factors from murine sarcoma virus-transformed cells, 4001 Human placental cells transformed by tsA mutants of simian virus 40:

Model system for study of placental functions, 1409 Human tumors and human malignant cell lines analyzed for BK

virus-specific DNA sequences, 454 Infection with paramyxoviruses stimulates synthesis of cellular


Isolation of stable rat sarcoma viruses in vitro, 2972 Lack of correlation between tumorigenicity and level of plasminogen

activator in fibroblasts transformed by Rous sarcoma virus, 4967 Molecular association between transplantation antigens and cell surface

antigen in adenovirus-transformed cell line, 5674 Monovalent antibodies directed to transformation-sensitive membrane

components inhibit viral transformation, 6049 New region of simian virus 40 genome required for efficient viral

transformation, 2473 Post-transcriptional suppression of globin gene expression in cells

transformed by avian erythroblastosis virus, 3776 Protein kinase activity associated with avian sarcoma virus src gene

product, 2021 Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein

with feline oncornavirus-associated cell membrane antigen (FOCMA) activity, 1505

Recombination between viral and cellular sequences generates transforming sarcoma virus, 5812

Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus, 5015




Species-specific cellular DNA-binding proteins expressed in mouse cells transformed by chemical carcinogens, 1647


Tumor-specific transplantation antigen: Ad2+nd1 hybrid virus used to identify the protein responsible for simian virus 40 tumor rejection and its genetic origin, 3055

Two types of human papillomaviruses in lesions of epidermodysplasia verruciformis, 1537


Viable deletion mutants in simian virus 40 early region, 4455



6412 Subject Index

Transglutaminase Transglutaminase activity in human lymphocytes: Early activation by

phytomitogens, 1157 Transition state theory

Kinetics of hemoglobin and transition state theory, 2108 Translation


Functional albumin mRNA decreased during estrogen-induced vitellogenin biosynthesis in avian liver, 5974

Hemin-controlled inhibitor of protein synthesis: Mode of action, 243 Immunological screening method to detect specific translation products,

2746 mRNA populations analyzed by cDNA-mRNA hybrid-mediated

inhibition of cell-free protein synthesis, 1217 Multiple forms of sarc gene proteins from Rous sarcoma virus RNA, 366 Ovalbumin: A secreted protein without a transient hydrophobic leader

sequence, 94 Phosphorylation of eukaryotic protein synthesis initiation factors, 108 Post-translational transport into intact chloroplasts of precursor to small

subunit of ribulose-1,5-bisphosphate carboxylase, 6110 Rat liver fatty acid synthetase mRNA translated in a cell-free system

derived from wheat germ, 730 Regulation of protein synthesis: Activatioln by double-stranded RNA of a

protein kinase that phosphorylates eukaryotic initiatioln factor 2, 1121 Rous sarcoma viral RNA translation inhibited by a specific

oligodeoxyribonucleotide, 285 Specific RNA sequences and gene products of MC29 avian acute

leukemia virus, 5874 Stuttering: High-level mistranslation in animal and bacterial cells, 1091 Thyroid and glucocorticoid hormones synergistically control growth

hormone mRNA in cultured GH1 cells, 45 Translational control by hemin is due to binding to cyclic

AMP-dependent protein kinase, 1148 Translational control: Recognition of methylated 5' end and an inlternal

sequence in eukaryotic mRNA by the initiatioln factor that binds methionyl-tRNAfet, 650

Translational specificity of Bacillus stearothermophilus ribosomes, 167 "Two out of three": Alternative method for codon reading, 1759

Translation inhibitor Inhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732 Isolation of two interferon-induced translational inhibitors: A protein

kinase and an oligo-isoadenylate synthetase, 4734 Regulation of protein synthesis in rabbit reticulocyte lysates by

heme-regulated protein kinase: Inihibition of interaction of Met-tRNAfMet binding factor with another initiation factor in formation of Met-tRNAfMet-40S ribosomal subunit complexes, 745


Transplant Electrophysiological analysis of reimnnervation of transplants in anterior

chamber of eye by autonomic ground plexus of iris, 1009 Transplantation

Proliferative capacity of murine hematopoietic stem cells, 490 Transport, active

Reduction of membrane potential, an immediate effect of colicin K, 2483 Secondary protein-chromophore interactions at Schiff base linkage in

bacteriorhodopsin: Molecular mechanism for proton pumping, 4642 Transport, amino-acid

Colchicine inhibits changes in amino acid transport and initiation of DNA synthesis in regenerating rat liver, 1394

-y-Glutamyl cycle functions in vivo using intracellular glutathione: Effects of amino acids and selective inhibition of enzymes, 5405

Isolated microvessels: Blood-brain barrier in vitro, 4544 Sodium-dependent amino acid transport by cultured hamster cells:

Membrane vesicles retain transport changes due to glucose starvatioi and cycloheximide, 5048


Transport, y-aminobutyric acid -y-Aminobutyric acid transport modulated in nerve endings: Role of

extracellular -^-aminobutyric acid and of cationic fluxes, 2981 Transport, catecholamine


Transport, chlortetracycline Membrane lateral phase separations and chlortetracycline transport by

Bacillus megaterium, 1319 Transport, cholesteryl ester


Transport, drug Conjugation of methotrexate to poly(L-lysine) increases drug transport

and overcomes drug resistance in cultured cells, 3867 Transport, electron


Pseudomonas cytochrome c551 at 2.0 A resolution: Enlargement of cytochrome c family, 2674

Regulation of Ca2+ release from mitochondria by oxidation-reduction state of pyridine nucleotides, 1690

Stoichiometry of vectorial H+ movements coupled to electron transport and to ATP synthesis in mitochondria, 5296

Thioredoxin induced by bacteriophage T4: Three-dimensional structure, 5827


Transport, epinephrine Transmembrane pH gradient: Role in epinephrine transport by

chromaffin granule membrane vesicles, 3713 Transport, glucose

Glucose binding and transport proteins extracted from fast-growing chicken fibroblasts, 5427

Insulin resistance due to a defect distal to insulin receptor: Demonstration in patient with leprechaunism, 3469

Transport, H+ Stoichiometry of vectorial H+ movements coupled to electron transport

and to ATP synthesis in mitochondria, 5296 Transport, histidine


Transport, intra-axonal Subcellular fractionation of intra-axonally transported polypeptides in

rabbit visual system, 505 Transport, intracellular

Mitochondria are associated with microtubules in cultured cells, 3863 Transport, ion


Saxitoxin: Binding to electrically excitable neuroblastoma cells, 218 Transport, iron

Siderophore electrochemistry: Relation to intracellular iron release mechanism, 3551

Transport, ovum Polycationic macromolecules inhibit cilia-mediated ovum transport in

rabbit oviduct, 4413 Transport, phosphate

Alternative membrane transport pathway for phosphate and adenine nucleotides in mitochondria and its possible function, 4788

Transport, potassium Potassium transport in L cells: Genetic alterations, 5589 Structural proteins of an ATP-driven potassium transport system in

Escherichia coli, 3216 Transport, protein


Post-translational transport into intact chloroplasts of precursor to small subunit of ribulose-1,5-bisphosphate carboxylase, 6110

Transport, proton Molecular mechanisms for proton transport in membranes, 298

Transport, reverse electron Alternative membrane transport pathway for phosphate and adenine

nucleotides in mitochondria and its possible function, 4788 Transport, ribonucleic acid

RNA transport from isolated rat liver nuclei: Activation energy, 5400 Transport, sodium

Energetics of sodium transport in toad urinary bladder, 4591 Transport, sugar

2-Deoxyglucose catabolized by phagocytic leukocytes in presence of 12-O-tetradecanoyl phorbol-13-acetate, 5422

Specificity of effects of cytochalasin B on transport and motile processes, 329

Transport, thymidine Specificity of effects of cytochalasin B on transport and motile processes,

329 Transposon

ColEl-derived plasmid copy-number mutant: Isolation and characterization, 5869


Temperature-sensitive Escherichia coli mutant producing a temperature-sensitive ( subunit of DNA-dependent RNA polymerase, 6177

Transverse tubular system Membrane sites in glycerinated chicken skeletal muscle fibers:


Tricarbonyl compound Bond angles in transition-metal tricarbonyl compounds: Test of the

theory of hybrid bond orbitals, 12 Trigonometric series

Some new singular Fourier-Stieltjes series, 5268 Triiodothyronine



Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle, 1369

Triphenylmethyl phosphonium ion Changes in membrane potential of human granulocytes antecede

metabolic responses to surface stimulation, 3818 Triphosphoinositide

see Phosphatidylinositol bisphosphate Triticum aestivum L.


Trophoblast Antigens of human trophoblasts: Role in normal and abnormal

pregnancies, 1947 Tropism, Fv-l

Structural markers on core protein p30 of murine leukemia virus: Functional correlation with Fv-1 tropism, 4170




Tropomyosin Specific phosphorylation at serine-283 of (v tropomyosin from frog

skeletal and rabbit skeletal and cardiac muscle, 3588 Troponin

Specific phosphorylation at serine-283 of ( tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle, 3588

Trout see Salmo gairdeneri

Trypanocidal factor Trypanocidal factor identified in normal human serum: High density

lipoprotein, 3450 Trypanosoma brucei


Trypanocidal factor identified in normal human serum: High density lipoprotein, 3450

Trypanosoma congolense Crossreacting determinants in variant-specific surface antigens of

African trypanosomes, 1989 Trypanosoma musculi


Trypanosoma rhodesiense Trypanocidal factor identified in normal human serum: High density

lipoprotein, 3450 Trypsin

Interaction of fluoride- and guanylyl-5'-imidodiphosphate-regulatory proteins with adenylate cyclase, 3693

Trypsin (EC 3.4.21.4) Active site of bovine trypsin: Interactive computer surface graphics

approach, 5409 Tryptophan

see also Operon, trp Diamagnetic anisotropy and orientation of ( helix in frog rhodopsin and

meta II intermediate, 5471 Interaction of mycobacterial polymethylpolysaccharides with paranaric



Molecular cloning of gemnetically active fragments of Bacillus DNA in Bacillus subtilis and properties of vector plasmid pUBO10, 1423


Tryptophan synthetase Expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5)

controlled by a bacterial insertion element (IS2), 6172 Tubulin


Cytoplasmic microtubular images in glutaraldehyde-fixed tissue culture cells by electron microscopy and by iinmunofluorescence microscopy, 1820

Differences in a and 3 polypeptide chains of tubulin resolved by electron microscopy with image reconstruction, 5006


Role of nucleotides in tubulin polymerization: Effect of guanylyl 5'-methylene diphosphonate (correction), 1608

Role of nucleotides in tubulin polymerization: Effect of guanosine 5'-methylene diphosphonate, 3178



Tubulin from the yeast Saccharomyces cerevisiae identified, 4962 Tuftsin

Tuftsin (an Ig-associated tetrapeptide) triggers immunogenic function of macrophages: Implications for activation of programmed cells, 3400

Tumor see also Cell, ascites tumor; Cell, Leydig tumor; Cell, neuroblastoma;

Cell, pituitary tumor; specific tumors Antibody response of mice to chemically induced tumors, 955 Codistribution of pericellular matrix proteins in cultured fibroblasts and

loss in transformation: Fibronectin and procollagen, 4944 2-Deoxyglucose catabolized by phagocytic leukocytes in presence of

12-O-tetradecanoyl phorbol-13-acetate, 5422 Differences in behavior and prognosis between leukemic and





Estrogen induction of growth factors specific for hormone-responsive mammary, pituitary, and kidney tumor cells, 3786

Growth of transformed cells and tumors inhibited by endogenous acceptor of galactosyltransferase, 4426

Nucleotide specificity in DNA scission by neocarzinostatin, 3603 Periodic loss of reactivity of a myeloma tumor with cytotoxic

thymus-derived lymphocytes, 441 Sequence specific cleavage of DNA by antitumor antibiotics

neocarzinostatin and bleomycin, 3608

Subject Index 6413



Tumor promoter induces sister chromatid exchanges: Relevance to mechanisms of carcinogenesis, 6149



Tumor, ascites Bone marrow colony-stimulating factor and tumor resistance-enhancing

activity of postendotoxin mouse sera, 2893 Tumorigenicity


Loss of proliferative calcium dependence: Simple in vitro indicator of tumorigenicity, 6069

Malignancy in human cells: Malignant and transformed phenotypes are under separate genetic control, 1466

Proteins conferred by the virulence-specifying plasmid of Agrobacterium tumefaciens C-58, 3796


Tumorigenicity of optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: Exceptional activity of (+)-73,8(v-dihydroxy-9sY,10eo-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene, 5358

Tumor immunity Tumor antigens enhance tumor growth in vivo by interacting with a

radiosensitive (suppressor?) cell population, 436 Tumor, mouse mammary


Viral proteins in mouse mammary tumors detected by immunoperoxidase staining of paraffin sections, 1524

Tumor, testicular Gonadotropin binding and stimulation of steroidogenesis in Leydig

tumor cells, 99 Tumor virus

see also specific viruses Detection in human breast carcinomas of antigen immunologically

related to a group-specific antigen of mouse mammary tumor virus, 1529


Envelope glycoprotein of avian sarcoma virus: Imnmunogenicity, 1962 Host-range variants of mouse mammary tumor viruses isolated that

efficiently infect cells in vitro, 5718 Mapping of linear and circular forms of mouse mammary tumor virus



Mtv-2 gene responsible for early appearance of mammary tumors in GR mouse by nucleic acid hybridization, 2368



Turbidity Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate,

and subfragments of myosin, 54 Turnip yellow mosaic virus


Type C virus Amino- and carboxyl-terminal amino acid sequences of proteins coded

by gag gene of murine leukemia virus, 1404 Cells nonproductively transformed by Abelson murine leukemia virus



Endogenous type C virus activated in BALB/c mouse cells by herpesvirus DNA, 4558

Endogenous viral genes of White Leghorn chicken: Common site of residence and sites associated with specific phenotypes of viral gene expression, 5941

Generation of oncogenic type C viruses: Rapidly leukemogenic viruses derived from C3H mouse cells in vivo and in vitro, 2468

Genetic recombination between mouse type C RNA viruses: Mechanism for endogenous viral gene amplification in mammalian cells, 923

Human antibodies reactive with purified envelope antigens of primate type C tumor viruses, 5692

Isolation of stable rat sarcoma viruses in vitro, 2972 RNase Tl-resistant oligonucleotides derived from genomes of Akv and

MCF murine leukemia viruses: Characterization and mapping, 495 Serological characterization of B-tropic viruses of C57BL mice: Possible



Tyrosinase see Monophenol monooxygenase

Tyrosine Cooperativity eliminated in aspartate transcarbamylase by nitration of

single tyrosine residue, 2654



6414 Subject Index


Tyrosine aminotransferase (EC 2.6.1.5) Acceleration of rate of elongation of tyrosine aminotransferase nascent

chains by dibutyryl cyclic AMP, 140 Tyrosine hydroxylase

see Tyrosine 3-monooxygenase Tyrosine 3-monooxygenase (EC 1.14.16.2)

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: Mechanism of enzyme activation, 4744

Nerve growth factor-mediated induction of tyrosine hydroxylase in clonal pheochromocytoma cell line, 4587


UDPgalactose-lipopolysaccharide galactosyltransferase (EC 2.4.1.44) Conformation of a membrane glycosyltransferase modulated by specific

lipids, 3669 Ulcerative colitis

Colonic tissue-bound antibodies: Isolation and characterizatioln from patients with idiopathic ulcerative colitis, 4528

Ultracentrifugation Disulfide bond connecting the chains of ricin, 1096 Disulfide bond connecting the chains of ricin (correction), 4067 Formation of high density lipoprotein2-like particles during lipolysis of

very low density lipoproteins in vitro, 4519 Ultrasonic relaxation

Phospholipid bilayers in the transitioln zone: Nanosecond relaxation processes, 3011

Ultraviolet light mapping Units of transcription for cytoplasmic RNA in mouse myeloma cells,

4374 Uracil


Uracil incorporation into nascent DNA of thymine-requiring mutant of Bacillus subtilis 168, 2195


Uracil, bromo- Bromodeoxyuridine mutagenesis in mammalian cells: Mutagenesis is

independent of amount of bromouracil in DNA, 4982 Uracil N-glycosidase


Urate oxidase (EC 1.7.3.3) Biogenesis of peroxisomes: Intracellular site of synthesis of catalase and

uricase, 5066 Uricase

see Urate oxidase Uridine, alkyl-

Polynucleotides containing 02- and O4-alkyluridine: Preparation and template activities, 1722

Uridine diphosphate N-acetylglucosamine Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrients

by quiescent BALB/C3T3 cells, 3859 Uridine, 4-thio-


Uridyl(3'-5')adenyl-O,O-phosphorothioate Absolute configuration of diastereomers of adenosine


04 -(5-Uridylyl)tyrosine 04-(5-Uridylyl)tyrosine is the bond between genome linked protein and

RNA of poliovirus, 4868 Urokinase


Uteroglobin Progesterone-binding protein: Amino acid sequence, 5516

Uterus Opposing effects of estradiol and progesteronle on oxytocin receptors in

rabbit uterus, 2044

Vaccine Genetic dimorphism in influenza viruses: Characterization of stably


Streptococcal M protein: Repeating covalent structure, 3163 Vaccinia virus

Enzymatic conversion of 5'-phosphate-terminated RNA to 5'-di- and triphosphate-terminated RNA, 4793

In vitro inhibition of protein synthesis by purified cores from vaccinia virus, 175

Vaccinia virus DNA: Visualization of an inverted terminal repetition, 4863

Vacuole Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle:

Electron probe analysis, 1329 Vacuole, plant


Valence Chemistry of low-valent molybdenum phosphite complexes: Models of

seven-coordinate reaction intermediates, 1056


Valine Physical organization of ilvEDAC genes of Escherichia coli strain K-12,

89 Vanadate


van der Waals loop Interacting enzyme systems at steady state: Location of phase transition

in approximations of mean field type, 3015 Vascular endothelium

Fibronectin: Identification, localization, and role in cultured bovine endothelial cells, 3273

Vasopressin Conditioned behavior of rats modified by neurohypophyseal hormones

and analogues, 2493 Norepinephrine, vasopressin, glucagon, and A23187 induce efflux of

calcium from exchangeable pool in isolated rat hepatocytes, 2234 Venom

see also Toxin Venom, black widow spider


Venom coagglutinin Venom coagglutinin: Activator of platelet aggregation dependent on von

Willebrand factor, 4514 Venom, snake


Veratridine Depolarizing agents and cyclic nucleotides regulate phosphorylation of

specific neuronal proteins in rat cerebral cortex slices, 5195 Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic

monophosphate levels in neuroblastoma cells, 6295 Vesicle, coated

Coated vesicles: Characterization, selective dissociation, and reassembly, 4394

Vesicular stomatitis virus Inhibition of translation by poliovirus: Inactivation of a specific

initiation factor, 2732 Nucleotide sequence homology at 3' termini of RNA from vesicular

stomatitis virus and its defective interfering particles, 3225 Oligosaccharide chains are trimmed during synthesis of envelope

glycoprotein of vesicular stomatitis virus, 754 Sequence of a RNA templated by 3'-OH RNA terminus of defective

interfering particles of vesicular stomatitis virus, 4704 Vesicular stomatitis virus glycoproteiin is necessary for H-2-restricted

lysis of infected cells by cytotoxic T lymphocytes, 970 Vesicular stomatitis virus membrane glycoprotein: In vitro synthesis and

insertion into membranes, 715 Vibrio cholerae

Affinity filters, approach to isolation of tox mutants of Vibrio cholerae, 941

Vimentin Different intermediate-sized filaments distinguished by

immunofluorescence microscopy, 5034 Virus

see specific viruses Virus assembly

Symmetry mismatch and DNA packaging in large bacteriophages, 4779 Virus budding

Asymmetric budding of viruses in epithelial monolayers: Model system for study of epithelial polarity, 5071

Virus encapsidation Kinetics of biphasic reconsitution of tobacco mosaic virus in vitro, 1727

Virus integration Structure of X att sites generated by int-dependent deletions, 5437

Viscoelastometry Tetrahymena macronuclear DNA: Viscoelastic studies, 5062

Vision Law of perceptual stability: Abstract foundations, 2049

Visna virus Viral sequences of low reiteration frequency detected by in situ

hybridization, 6125 Visual transduction


Vitamin A 5,8-Oxyretinoic acid isolated from small intestine of vitamin A-deficient


rats dosed with retinoic acid (correction), 5244 Vitamin B-6

see Pyridoxine Vitamin C

see Ascorbic acid Vitamin D

Direct C-1 hydroxylation of vitamin D compounds: Preparation of la-hydroxyvitamin D3, la,25-dihydroxyvitamin D3, and 1a-hydroxyvitamin D2, 2080

Vitamin K Bovine protein C: Amino acid sequence of the light chain, 5889 Vitamin K-dependent carboxylase: A hydroperoxide intermediate in the

reaction, 5413 Vitellogenin

Functional albumin mRNA decreased during estrogen-induced vitellogenin biosynthesis in avian liver, 5974




Primary induction of vitellogenin mRNA in rooster by 17/3-estradiol, 1815

Xenopus oocytes: Long-term growth and differentiation in a defined medium, 5534

Vole see Microtus pennsylvanicus

Voltage clamp Cole-Moore effect in the frog node, 3254 In uitro differentiation of a fast Na- conductance in embryonic heart cell

aggregates, 2776 Voltage-controlled channel

Matrix protein from Escherichia coli membranes forms voltage-controlled channels in lipid bilayers, 3751

von Willebrand disease Venom coagglutinin: Activator of platelet aggregation dependent on von

Willebrand factor, 4514

Wart virus Two types of human papillomaviruses in lesions of epidermodysplasia

verruciformis, 1537 Wasp

see Philanthus zebratus Cresson Wave mechanics

Locality principle in wave mechanics, 5270 Weyl-Kac character formula

Lie algebras and classical partition identities, 578 Wheat

see Triticum aestivum L. Wheat germ agglutinin

Diphtheria toxin has properties of a lectin, 261 Ligands containing heavy atoms: Perturbation of phosphorescence of a

tryptophan residue in bindinlg site of wheat germ agglutinin, 1324 White dwarf

Kinematics of faint white dwarfs, 4640 Whittaker model

Automorphic L-functions of half-integral weight, 1620 Woodchuck

see Marmota monax Wound healing

Brain-derived fibroblast growth factor: Identity with a fragment of basic protein of myelin, 4675

Writhing number Decomposition of linking number of a closed ribbon: Problem from

molecular biology, 3557

Xenopus laevis see also Oocyte, Xenopus laeuis Eukaryotic tRNA genes: Specific transcription in Xenopus germinal

vesicle extracts, 4819 Membrane particle aggregates in innervated and noninnervated cultures

of Xenopus embryonic muscle cells, 500 Xeroderma pigmentosum



Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after multraviolet radiation, 1984

Subject Index 6415

X-ray see also Irradiation, x-

X-ray absorption spectroscopy Blue copper site in oxidized azurin characterized by extended x-ray


X-ray beam Mathematical aspects of divergent beam radiography, 2055

X-ray crystallography see also Crystal; Crystallography Changes in three-dimensional structure of concanavalin A upon

demetallization, 2286 Glucose-induced conformational change in yeast hexokinase, 4848 Structure of hemoglobins Zurich [His E7(63)/3-Arg] and Sydney [Val

Ell(67)3--Ala] and role of distal residues in ligand binding, 1076 Thioredoxin induced by bacteriophage T4: Three-dimensional structure,

5827 X-ray diffraction

see also Diffraction Crystal structures of a"-cerium phases, 1066 Method to assess similarity of protein structures, with applications to T4

bacteriophage lysozyme, 2180 Ten-nanometer filaments of hamster BHK-21 cells and epidermal

keratin filaments have similar structures, 6098 Three-dimensional structures of aspartate carbamoyltransferase from

Escherichia coli and of its complex with cytidine triphosphate, 5276 o-Xylene


4i-Xylosidase Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher

disease, 2448

Yeast see Saccharomyces cerevisiae

Z-disc Membrane sites in glycerinated chicken skeletal muscle fibers:


Zea mays Maize plastid gene expressed during photoregulated development, 3060 Mitochondrial translation products: Variation associated with

male-sterile cytoplasms in maize, 3841 Zein messenger RNA: Purification and translation from maize

endosperm protein bodies, 696 2ein


Zinc Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase

with Zn2+ as cofactor, 2185 RNA metabolism, manganese, and RNA polymerases of zinc-sufficient

and zinc-deficient Euglena gracilis, 4175 T-cell helper function: Regeneration in zinc-deficient adult mice, 5660

Zymogram Membrane vesicles from Escherichia coli: Molecular structure, 3148



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