Subject Index, January - December 1975 || Subject Index

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Proc. Nat. Acad. Sci. USA Vol. 72, pp. J1-63, Subject Index, 1975

Introduction to

The terms in the Subject Index for Vol PROCEEDINGS OF THE NATIONAL ACA

mainly from titles and key terms of articl computer; numbers, conformational pref between words are disregarded in alphabe the title of the article (or a suitable modii page number. Titles are listed in alphabe

Classifications (e.g., Physics, Mathen published are used as index terms only if that are concerned in some major way "Methodology" as well as under more sF diseases are indexed under "Diseases of I tions) as well as under more specific tern occurred are indexed under the term "Cori selected for the paper itself. Organisms ar scientific names were provided in the pape Genes are listed together as, for example

Because the PROCEEDINGS urges auth ommendations of the nomenclature con proposed by the International Union of Commission on Biochemical. Nomenclatu: an index that conforms with this policy. clature was not attempted and the index , for correct or recommended usage. In a mendations of the commissions were nece, not abbreviated even if specific recomm missions; and in some instances, words wit] tRNA is indexed as "Ribonucleic acid, t pounds are indexed as the parent compow monophosphate is indexed as "Adenosine The "Recommended Name" from the 19, Union of Pure and Applied Chemistry and [Enzyme Nomenclature (1973), America enzymes whenever Enzyme Commission pers, since the 1972 recommendations throughout 1975. EC numbers are listed al was printed in the paper. [Thus, some ( sinetriphosphatase" and "Adenosinetrip

1

Subject Index

ume 72, January-December 1975, of the DEMY OF SCIENCES USA were chosen es. The index terms are alphabetized by ixes, Greek letters, hyphens, and spaces Lization. After each index term is printed 'ication of the title) and the appropriate tical order under the index terms. latics) under which papers have been it seemed this would be helpful. Papers with methodology are indexed under

ecific terms. Papers relevant to human Luman beings" (with some subclassifica- Ls. Corrections to papers in which errors rections" as well as under the index terms e indexed by their scientific names when rs; suitable cross-references are provided. "Gene, lac."

ors to follow the tentative rules and rec- imissions (e.g., for biochemistry, those Pure and Applied Chemistry and the

re), an effort has been made to construct However, correction of errors in nomen- 3hould not be looked upon as a reference idition, some exceptions to the recom- isary. Index terms themselves are usually endations have been made by the com- lin an index term were rearranged. (Thus, ransfer.") In general, analogues of com- id. (Thus, dibutyryl adenosine 3':5'-cyclic 3':5'-cyclic monophosphate, dibutyryl-.") '2 recommendations of the International the International Union of Biochemistry n Elsevier, New York] has been used for (EC) numbers were published in the pa- were followed by the editorial staff

3 part of the entry only if the EC number enzymes have two entries, e.g., "Adeno- hosphatase (EC 3.6.1.3)."]



Proceedings of the National

Subject Inde3 JANUARY-DI

List of issues for Vol. 72 (1975) of the PROCEEDINGS

Inclusive No. Month pagination

1 January 1-412 2 February 413-776 3 March 777-1220 4 April 1221-1648 5 May 1649-1980 6 June 1981-2472 7 July 2473-2836 8 August 2837-3264 9 September 3265-3788

10 October 3789-4192 11 November 4193-4684 12 December 4685-5176

Abelian integral Complete solution of periodic Toda problem, 2879

Absorbance change Light-dependent absorption and selective scattering changes at 518 nm

in chloroplast thylakoid membranes, 3858 Acetoxycycloheximide

Effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory, 479

Acetylation Acetylation of prostaglandin synthase by aspirin, 3073

Acetylcholine Electrostatic basis of Mg++ inhibition of transmitter release (correction),

409 Molecular model of postsynaptic potential, 1749 Voltage-dependence of drug-induced conductance in frog neuromuscular

junction, 2140 Acetylcholine receptor

see Receptor, acetylcholine Acetylcholinesterase (EC 3.1.1.7)

Catalysis by acetylcholinesterase: Evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis, 3834

N-Acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Lipoteichoic acid: 'Specific inhibitor of autolysin activity in

pneumococcus, 1690 Acetylsalicylic acid

Acetylation of prostaglandin synthase by aspirin, 3073 N-Acetyltransferase

see Arylamine acetyltransferase (EC 2.3.1.5) Acheta domesticus

Central connections of receptors on rotated and exchanged cerci of crickets, 966

Acid phosphatase (EC 3.1.3.2) Cytochemical studies of Golgi apparatus, GERL, and lysosomes in

neurons of dorsal root ganglia in mice, 508 Gene dosage: Assignment of erythrocyte acid phosphatase locus to

chromosome 2, 4526 Aconitine

Cooperative activation of action potential Na+ ionophore by neurotoxins, 1782.

Cooperative activation of action potential Na+ ionophore by neurotoxins (correction), 3260

Acridine DNA polyintercalating drugs: DNA binding of diacridine derivatives,

2915 ACTH

see Corticotropin

Academy of Sciences (USA)

: to Volume 72 ICEMBER. 1975

Actin Changing patterns of actin localization during cell division, 1913 Conformational change and cooperativity in actin filaments free of

tropomyosin, 3412 Decrease in membrane-associated actin of fibroblasts after

transformation of Rous sarcoma virus, 746 Major nonhistone proteins of rat liver chromatin: Preliminary

identification of myosin, actin, tubulin, and tropomyosin, 3902 Motion of subfragment-1 in myosin and its supramolecular complexes:

Saturation transfer electron paramagnetic resonance, 1729 Organization of actin and myosin in normal and transformed cultured

cells, 994 Presence of actin during chromosomal movement, 2451 Translation in vitro of rat brain messenger RNA coding for tubulin and

actin, 701 Visualization of actin fibers associated with cell membrane in amoebae of

Dictyostelium discoideum, 1758 Actinomycin D

Functional level of rat liver tryptophan 2,3-dioxygenase messenger RNA during superinduction of enzyme with actinomycin D, 4285

Action potential Spike-forming model of neural membrane, 3468 Spike-forming model of neural membrane: Computer simulation of some

perfused axon experiments, 4859 Activated state

Rate processes and compensation rule, 999 Activation, free energy of

Protein hydration changes during catalysis: Mechanism of enzymic rate-enhancement and ion activation/inhibition of catalysis, 3305

Activation volume Activation volumes in enzymic catalysis: Their sources and modification

by low-molecular-weight solutes, 3014 Active site

see also Enzyme Synthetic analogs of active sites of iron-sulfur proteins:

Bis(o-xylyldithiolato)ferrate(III) monoanion, a structurally unconstrained model for rubredoxin Fe-S4 unit, 2868

Active transport see Transport

Acyl(+)carnitine Mitochondrial carnitine acylcarnitine translocase system, 883

1-Acylglycerolphosphate acyltransferase (EC 2.3.1.-) Separation of 1-acylglycerolphosphate acyltransferase and

1-acylglycerolphosphorylcholine acyltransferase of rat liver microsomes, 600

1-Acylglycerolphosphorylcholine acyltransferase (EC 2.3.1.23) Separation of 1-acylglycerolphosphate acyltransferase and


Adaptation Transient response to chemotactic stimuli in Escherichia coli, 3235

Adenine Adenine formation from adenosine by mycoplasmas: Adenosine

phosphorylase activity, 1401 Adenine, 1,N6-etheno-

Dynamic and static quenching' of 1,N6-ethenoadenine fluorescence in nicotinamide 1,N6-ethenoadenine dinucleotide and in 1,N6-etheno-9-[3-(indol-3-yl)propyl]adenine, 3966

Adenine phosphoribosyltransferase (EC 2.4.2.7) Human gene expression in rodent cells after uptake of isolated

metaphase chromosomes, 1797 Adenosine 3':5'-cyclic monophosphate in animal cells

Antigen-stimulated changes in cyclic nucleotide levels in mouse, 2320 Association of cyclic AMP-dependent protein kinase with purified

translational inhibitor isolated from hemin-deficient rabbit reticulocyte lysates, 4849

Association of mouse liver adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels with Histocompatibility-2 genotype, 2644

ATP, cyclic AMP, and magnesium increase affinity of rat striatal tyrosine hydroxylase for its cofactor, 2955

Beta-adrenergic stimulation of pineal N-acetyltransferase: Adenosine 3':5'-cyclic monophosphate stimulates both RNA and protein synthesis, 2107

Calcium-binding protein as calcium-dependent regulator of brain adenylate cyclase, 64

Cyclic 3':5'-adenosine monophosphate activation of tyrosine hydroxylase in rat brain, 789



Proc. Nat. Acad. Sci. USA 72 (1975)

Cyclic AMP and immune responses: Changes in splenic level of cyclic AMP during response of mice to antigen, 888

Effect of nerve growth factor on cyclic AMP levels in superior cervical ganglia of rat, 4769

Epithelial cell death and cyclic AMP increase during palatal development, 874

Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic GMP in rat liver, intestine, and testis, 2022

Isolation of glycogen synthase I kinase that is independent of adenosine 3':5'-monophosphate, 2197

Lack of detectable change in cyclic AMP during cardiac inotropic response to isoproterenol immobilized on glass beads, 824

Oxygen and cyclic nucleotides in human umbilical artery, 3883 Protein kinase activation as early event in trans-synaptic induction of

tyrosine 3-monooxygenase in adrenal medulla, 1152 Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma

cells, 3472 Regulation of sensitivity to /-adrenergic stimulation in induction of

pineal N-acetyltransferase, 1661 Translocation of heart cAMP-dependent protein kinase, 1501

Adenosine 3':5'-cyclic monophosphate in cultured animal cells Bioregulation of lysosomal enzyme secretion from human neutrophils:

IRoles of guanosine 3':5'-monophosphate and calcium in stimulus-secretion coupling, 108

Cell cycle specific fluctuations in adenosine 3':5'-cyclic mosnophosphate and polyamines of Chinese hamster cells, 1482

Cyclic AMP and cyclic GMP concentrations in serum- and density-restricted fibroblast cultures, 1063

Cyclic AMP-mediated induction of ornithine decarboxylase of glioma and neuroblastoma cells, 3087

Cyclic AMP modulates microvillus formation and agglutinability in transformed and normal mouse fibroblasts, 1263

Cyclic AMP, nonessential regulator of cell cycle, 878 Cytoplasmic microtubules in normal and transformed cells in culture:

Analysis by tubulin antibody immunofluorescence, 4981 Human synoviocytes: Activation and desensitization by prostaglandins

and l-epinephrine, 3124 Inhibition of replication of normal adrenocortical cells in culture by

adrenocorticotropin, 113 . Structural gene mutation affecting the regulatory subunit of cyclic

AMP-dependent protein kinase in mouse lymphoma cells, 5051 Adenosine 3':5'-cyclic monophosphate in microorganisms

Adenosine 3':5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli, 2300

Chemotactic signals induce cell differentiation in Dictyostelium discoideum, 3163

Cyclic nucleotide metabolism coupled to cytodifferentiation of Blastocladiella emersonii, 442

In vitro synthesis of constitutive enzyme of Escherichia coli, 6-phosphogluconate dehydrogenase, 4381

Low-molecular-weight DNA-binding protein, H1 factor, affects in vitro transcription of lactose operon in Escherichia coli, 333

Regulation of development in Myxococcus xanthus: Effect of 3':5'-cyclic AMP, ADP, and nutrition, 518

Signal input for chemotactic response in cellular slime mold Dictyostelium discoideum, 4991

Adenosine 3':5'-cyclic monophosphate-dependent phosphorylation Cyclic AMP-dependent endogenous phosphorylation of

microtubule-associated protein, 177 Adenosine 3':5'-cyclic monophosphate, dibutyryl

Follicle-stimulating hormone or dibutyryl cyclic AMP induces structural changes on presumptive Sertoli cells in culture, 1838

Adenosine 3':5'-cycic monophosphate, P-O-ethyl ester Tumor-inhibiting properties of the neutral P-O-ethyl ester of adenosine

3':5'-monophosphate in correlation with its crystal and molecular structure, 1335

Adenosine 3':5'-cyclic monophosphate phosphodiesterase (EC 3.1.4.17) Changes in cyclic nucleotide metabolism in aorta and heart of

neurogenically hypertensive rats: Possible trigger mechanism of hypertension, 2135

Adenosine diphosphate Regulation of development in Myxococcus xanthus: Effect of 3':5T-cyclic

AMP, ADP, and nutrition, 518 Adenosine diphosphate ribose, protein-bound

Macromolecular enzymatic product of NAD+ in liver mitochondria, 1436 Adenosine-diphosphate-ribosyl transferase

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin, 2284

Adenosine phosphorylase Adenine formation from adenosine by mycoplasmas: Adenosine

phosphorylase activity, 1401 Adenosine, 3'-terminal of phenylalanine transfer ribonucleic acid

Phenylalanyl-tRNA synthetase from baker's yeast: Role of 3'-terminal adenosine of tRNAPhe in enzyme-substrate interaction studied with 3'-modified tRNAPhe species, 1378

Adenosinetriphosphatase Association of ;X174 DNA-dependent ATPase activity with Escherichia

coli protein, replication factor Y, required for in vitro synthesis of qbX174 DNA, 3342

Oxygen exchange in y-phosphoryl group of protein-bound ATP during Mg2+-dependent adenosine triphosphatase activity of myosin, 2592

Viability of Escherichia coli treated with colicin K, 4631 Adenosine triphosphate

ATP binding to progesterone receptor, 901 ATP, cyclic AMP, and magnesium increase affinity of rat striatal

tyrosine hydroxylase for its cofactor, 2955 Functional arginyl residues as ATP binding sites of glutamine synthetase

Subject Index 3

and carbamyl phosphate synthetase, 2616 Oxygen exchange in y-phosphoryl group of protein-bound ATP during

Mg2+-dependent adenosine triphosphatase activity of myosin, 2592 Adenosine triphosphate, 2-amino-2'-deoxy-

Amino acids are not all initially attached to the same position on transfer RNA molecules, 3044

Adenosine triphosphate:glutamine synthetase adenylyltransferase (EC 2.7.7.42)

w-Aminoalkyl agaroses in resolution of enzymes involved in regulation of glutamine metabolism, 3397

Adenosine triphosphate phosphoribosyltransferase (EC 2.4.2.17) Histidine regulation in Salmonella typhimurium: Activator-attenuator

model of gene regulation, 3453 Regulation of histidine operon does not require hisG enzyme, 5021

S-Adenosylmethioni ne Biosynthesis of ribosylthymine in the transfer RNA of Streptococcus

faecalis: Folate-dependent methylation not involving S-adenosylmethionine, 528

S-Adenosylmethionine decarboxylase (EC 4.1.1.50) Cell cycle specific fluctuations in adenosine 3':5'-cyclic monophosphate

and polyamines of Chinese hamster cells, 1482 Adenovirus

Adenovirus-2 mRNA is transcribed as part of high-molecular-weight precursor RNA, 4445

Arrangement of sequences in the inverted terminal repetition of adenovirus 18 DNA, 3039

Cleavage of adenovirus messenger RNA and of 28S and 18S ribosomal RNA by RNase III, 3077

Mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments, 1344

Temperature-sensitive cell mutations that inhibit adenovirus 2 replication, 328

Adenylate cyclase (EC 4.6.1.1), bacterial Interaction of enzyme I of the phosphoenolpyruvate:sugar

phosphotransferase system with adenylate cyclase of Escherichia coli, 2920

Adenylate cyclase (EC 4.6.1.1), brain Calcium-binding protein as calcium-dependent regulator of brain

adenylate cyclase, 64 Adenylate cyclase (EC 4.6.1.1), erythrocyte

Nicotinamide adenine dinucleotide in action of cholera toxin in vitro, 2064

Adenylate cyclase, membrane Dopamine receptor binding in corpus striatum of mammalian brain, 4655

Adenylate cyclase (EC 4.6.1.1), membrane Action of feedback regulator on adenylate cyclase, 1773 Activation of adenylate cyclase by phosphoramidate and phosphonate

analogs of GTP: Role of covalent enzyme-substrate intermediates in hormonal activation, 1739

Activation of adenylate cyclase by cholera toxin, 3438 Catecholamine-induced subsensitivity of adenylate cyclase associated

with loss-of fl-adrenergic receptor binding sites, 1945 Cellular levels of feedback regulator of adenylate cyclase and effect of

epinephrine and insulin, 4739 Cholera toxin activation of adenylate cyclase in cancer cell membrane

fragments, 2572 Fatty acids as modulators of membrane functions:

Catecholamine-activated adenylate cyclase of turkey erythrocyte, 3433 Identification of cardiac /f-adrenergic receptors by (-) [3H]alprenolol

binding, 1564 Mechanism of action of cholera toxin and mobile receptor theory of

hormone receptor-adenylate cyclase interactions, 33 Stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol:

Effect of cholera toxin, 3561 Adenylate cyclase (EC 4.6.1.1), neuroblastoma x glioma hybrid

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance, 3092

Morphine receptors as regulators of adenylate cyclase activity, 590 Adenylate cyclase (EC 4.6.1.1), pineal gland

Rapid changes in rat pineal /-adrenergic receptor: Alterations in 1-[3H]alprenolol binding and adenylate cyclase, 3735

Adenylate cyclase (EC 4.6.1.1), testis Mn +-Sensitive, "soluble" adenylate cyclase in rat testis, 1097

Adenylate energy charge ratio Use of adenylate energy charge ratio to measure growth state of natural

microbial communities, 2112 Adiabatic evolution

Adiabatic evolution of plasma equilibrium, 3789 Adipimidate, dimethyl

Dimethyl adipimidate: New antisickling agent, 43 Adipocyte

Cellular levels of feedback regulator of adenylate cyclase and effect of epinephrine and insulin, 4739

Ultrastructural localization of insulin receptors on adipocytes, 3526 Adrenalin

see Epinephrine Adrenal medulla

Protein kinase activation as early event in trans-synaptic induction of tyrosine 3-monooxygenase in adrenal medulla, 1152

/,-Adrenergic stimulation Regulation of sensitivity to /3-adrenergic stimulation in induction of

pineal N-acetyltransferase, 1661 Adrenocorticotropic hormone

see Corticotropin Adriamycin

Thermochemotherapy: Synergism between hyperthermia (42-43?) and adriamycin (or bleomycin) in mammalian cell inactivation, 937



4 Subject Index

Aedes aegypti Ovary as a source of a-ecdysone in an adult mosquito, 3255

Aeql)orea Chemical nature of bioluminescence systems in coelenterates, 1546

Aequorin Calcium role in depolarization-secretion coupling: Aequorin study in

squid giant synapse, 187 Renilla-type luciferin extracted from calcium-activated photoproteins

aequorin, mnemiopsin, and berovin, 2530 Aerobacter aerogenes

see also Klebsiella pneumoniae Stereochemistry of decarboxylation of trans-4-hydroxycinnamic acid by

Aerobacter, 1681 Affinmity labeling

see also Photoaffinity labeling Affinity labeling of the ribosomal decoding site with an AUG-substrate

analog, 1505 Photoincorporation of puromycin and

N-(ethyl-2-diazomalonyl)puromycin into Escherichia coli ribosomes, 2974

Agarose, w-aminoalkyl w-Aminoalkyl agaroses in resolution of enzymes involved in regulation of

glutamine metabolism, 3397 Age, of clam

Slow growth rate of deep-sea clam determined by 228Ra chronology, 2829 Agglutination, cell

Colchicine affects kinetics of concanavalin A-mediated agglutination of hepatoma cells and plasma membranes from liver and hepatoma cells, 498


Membrane differences in peripheral blood lymphocytes from patients with chronic lymphocytic leukemia and Hodgkin's disease, 2428

Agglutinin Major cell surface glycoprotein of chick embryo fibroblasts is an

agglutinin, 3158 Aggregation

see Cell aggregation Aggression pattern

Aggression patterns and speciation, 3250 Aging

Aging and its relation to cell growth and differentiation in Drosophila imaginal discs: Developmental response to growth restricting conditions, 4674

Aspartic acid racemization in tooth enamel from living humans, 2891 Binding of autologous erythrocytes to immature T-cells, 3201 Changes in relative levels of guanosine-3':5'-monophosphate-dependent

and adenosine-3':5'-monophosphate-dependent protein kinases in lung, heart, and brain of developing guinea pigs, 2256

Evolution of human longevity and genetic complexity governing aging rate, 4664

Agrostology Differential activity staining: Use in characterization of guanylyl-specific

ribonuclease in genus Ustilago, 4914 Aircraft

Estimates of stratospheric pollution by analytic model, 4711 Reactions of migrating birds to lights and aircraft, 1994

Alamethicin Alamethicin-mediated fusion of lecithin vesicles, 2170

D-Alanine carboxypeptidase Degradation of penicillin G to phenylacetylglycine by D-alanine

carboxypeptidase from Bacillus stearothermophilus, 3463 Albumin, bovine-serum

Brdicka currents observed with bovine serum albumin and completely reduced bovine serum albumin in presence of urea, 2044

Effects of tetraalkylammonium salts on Brdicka and presodium currents of bovine-serum albumin, 2863

Alcoholism Experimental alcohol-induced hepatic necrosis: Suppression by

propylthiouracil, 1137 Sequential production of fatty liver, hepatitis, and cirrhosis in

sub-human primates fed ethanol with adequate diets, 437 Aldehyde fixation of chromatin

Histone-histone propinquity by aldehyde fixation of chromatin, 1304 Aldosterone-induced protein

Identification of aldosterone-induced proteins in toad's urinary bladder, 4056

Alga see also Chlamydomonas; Crypthecodinium; Euglena Paleopleurocapsa wopfnerii gen. et sp. nov.: Late Precambrian alga and

its modern counterpart, 2488 Prokaryotic nature of red algal chloroplasts, 2310

Algebra, exterior Inequality among determinants, 3277

Algebraic curve over finite fields Some fundamental groups in arithmetic of algebraic curves over finite

fields, 3281 Algebraic description

Algebraic description of stereochemical correspondence, 2385 Alkaline phosphatase

Role of magnesium in Escherichia coli alkaline phosphatase, 2989 Alkaline phosphatase (EC 3.1.3.1)

Cobalt(III), probe of metal binding sites of Escherichia coli alkaline phosphatase, 394

Alkaline ribonuclease Interferon action: II. Membrane-bound alkaline ribonuclease activity in

chick embryo cells manifesting interferon-mediated interference, 182


Alkylating agent Induction by alkylating agents of sister chromatid exchanges and

chromatid breaks in Fanconi's anemia, 4066 Alkylation

Effects of alkylation of phosphodiesters and of bases on infectivity and stability of tobacco mosaic virus RNA, 2232

Allele Distribution of allelic frequencies in finite population under stepwise

production of neutral alleles, 2761 Allelopathy

Allelopathy and spatial competition among coral reef invertebrates, 5160 Allogeneic effect factor

Activation of T and B lymphocytes in vitro: Presence of /2-microglobulin determinants on allogeneic effect factor, 4577

Allosteric effect Interaction of hemoglobin with three ligands: Organic phosphates and

Bohr effect, 2465 Allosteric mechanism

Allosteric mechanism for codon-dependent tRNA selection on ribosomes, 4248

Allosteric transition theory Redox equilibria of liganded forms of methemoglobin, 3382

Allotype, complex Structure and regulation of immunoglobulins: Kappa allotypes in rat

have multiple amino-acid differences in constant region, 5046 Allozyme

see also Protein polymorphism Allozymic and chromosomal similarity in two Drosophila species, 4521 Genetic variation as a test of natural selection, 2145 Trophic radiation through polymorphism in cichlid fishes, 4669

Alprenolol Identification of cardiac /-adrenergic receptors by (-) [3H]alprenolol

binding, 1564 Rapid changes in rat pineal /-adrenergic receptor: Alterations in

1-[3H]alprenolol binding and adenylate cyclase, 3735 Altruism

Evolution of social behavior through interpopulation selection, 1199 General kin selection models for genetic evolution of sib altruism in

diploid and haplodiploid species, 4531 Group selection, altruism, reinforcement, and throwing in human

evolution, 3748 Theory of group selection, 143

Amide I Transition dipole coupling in Amide I modes of f3 polypeptides, 4933

Amine, biogenic Interaction of glyoxal and methylglyoxal with biogenic amines, 1610

Amine, primary o-Phthalaldehyde: Fluorogenic detection of primary amines in picomole

range: Comparison with fluorescamine and ninhydrin, 619 Amine-protecting group

Enzymes as reagents in peptide synthesis: Enzymatic removal of amine protecting groups, 2193

Amino acid Co-evolution theory of genetic code, 1909 Cycle of deprotonation and reprotonation energizing amino-acid

transport? 23 Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): Positive effector for

histidine operon transcription and general signal for amino-acid deficiency, 4389

Nonsaturable, homogeneous transport system in Bacillus subtilis: Genetic, kinetic, and affinity labeling studies, 814

Nuclear magnetic resonance spectroscopy: Reinvestigation of carbon-13 spin-lattice relaxation time measurements of amino acids, 1599

o-Phthalaldehyde: Fluorogenic detection of primary amines in picomole range: Comparison with fluorescamine and ninhydrin, 619

Regulation of herpesvirus macromolecular synthesis: Sequential transition of polypeptide synthesis requires functional viral polypeptides, 1276

Role of leucyl-tRNA synthetase in regulation of branched-chain amino-acid transport, 3921

Sidechain torsional potentials and motion of amino acids in proteins: Bovine pancreatic trypsin inhibitor, 2002

Utilization of L-cystine by y-glutamyl transpeptidase-y-glutamyl cyclotransferase pathway, 1985

Amino acid sequence see also specific proteins; Protein homology; Protein structure Amino-acid sequence of bovine carboxypeptidase B, 1666 Assessment of some problems associated with prediction of

three-dimensional structure of a protein from its amino-acid sequence, 1221

Constancy of amino-terminal amino-acid sequences of antibodies of defined specificity and shared idiotype from individual inbred mice, 3676

Substrate specificity of cyclic AMP-dependent protein kinase, 3448 2'(3')-O-Aminoacyloligonucleotide

Interaction of elongation factor TU with 2'(3')-0-aminoacyloligonucleotides derived from the 3' terminus of aminoacyl-tRNA, 2950

Aminoacyl-transfer ribonucleic acid synthetase Amino acids are not all initially attached to the same position on

transfer RNA molecules, 3044 Site of aminoacylation of tRNAs from Escherichia coli with respect to

2'- or 3'-hydroxyl group of terminal adenosine, 3049 Amino group

Amino groups in formation of human lymphocyte-xenogeneic erythrocyte rosettes; proposed mechanism for antigen recognition, 697




6-Aminolevulinic acid, biosynthesis Biosynthesis of i-aminolevulinic acid from intact carbon skeleton of

glutamic acid in greening barley, 2719 Amnesia


Neurohypophyseal hormones, analogs, and fragments: Their effect on puromycin-induced amnesia, 4180

d-Amphetamine d-Amphetamine disaggregates brain polysomes via a dopaminsergic

mechanism, 834 Ampicillin resistance

Translocation of plasmid DNA sequence which mediates ampicillin resistance: Molecular nature and specificity of insertion, 3623

a-Amylase Genetic control of endosperm amylase activity and gibberellic acid

responses in standard-height and short-statured wheats, 892 Amyloid fibril protein

Isolation of a low-molecular-weight serum component antigenically related to an amyloid fibril protein of unknown origin, 1473

Amyloidosis, systemic Isolation of a low-molecular-weight serum component antigenically

related to an amyloid fibril protein of unknown origin, 1473 Analgesia, hypnotic

Failure of opiate antagonist naloxone to modify hypnotic analgesia, 2041 Analysis

see Methodology (qualitative and quantitative analysis) Analysis of variance

Language boundaries and biological differentiation on Bougainville: Multivariate analysis of variance, 2247

Anaphylaxis Purification and synthesis of eosinophilotactic tetrapeptides of human

lung tissue: Identification as eosinophil chemotactic factor of anaphylaxis, 4123

Anchorage requirement Tumorigenicity of virus-transformed cells in nude mice is correlated

specifically with anchorage independent growth in vitro, 4435 Androgen

Androgen- and estrogen-binding macromolecules in developing mouse brain: Biochemical and genetic evidence, 4303

Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity, 1469

Very rapid effect of androgen on initiation of protein synthesis in prostate, 706

Anemia see Fanconi's anemia; Sickle cell disease; Thalassemia

Anesthesia Antagonistic effect of an inhalation anesthetic and high pressure on

phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers, 210

Local anesthetics affect transmembrane cytoskeletal control of mobility and distribution of cell surface receptors, 4430

Anisomycin Memory: Inhibitors of protein synthesis also inhibit catecholamine

synthesis, 4660 Annihilation

Source theory analysis of electron-positron annihilation experiments, 4725

Anthropology Language boundaries and biological differentiation on Bougainville:

Multivariate analysis of variance, 2247 Anthropometrics

Language boundaries and biological differentiation on Bougainville: Multivariate analysis of variance, 2247

Antibiotic see also specific antibiotics

Antibiotic, /-lactam Distinct penicillin binding proteins involved in the division, elongation,

and shape of Escherichia coli K12, 2999 Antibiotic resistance

see also Drug resistance; Plasmid Plasmid interactions in Staphylococcus aureus: Nonadditivity of

compatible plasmid DNA pools, 5031 Translocation of plasmid DNA sequence which mediates ampicillin

resistance: Molecular nature and specificity of insertion, 3623 Transposition of R factor genes to bacteriophage X, 3628

Antibody see also Immunoglobulin; Myeloma protein Activation of antibody Fc function by antigen-induced conformational

changes, 5111 Antibodies of identical idiotype but diverse immunoglobulin classes

produced by cells derived from single stimulated B cell, 1707 Antigen-induced conformational changes in antibodies and their Fab

fragments studied by circular polarization of fluorescence, 2775 Constancy of amino-terminal amino-acid sequences of antibodies of

defined specificity and shared idiotype from individual inbred mice, 3676

Cyclic AMP and immune responses: Changes in splenic level of cyclic AMP during response of mice to antigen, 888

Diversity of light chain variable region sequences among rabbit antibodies elicited by the same antigens, 2180

Localization of IgG effector site for monocyte receptors, 2081 Variability of three-dimensional structure in immunoglobulins, 819

Antibody to alloantiserum Idiotype positive T cells visualized by autoradiography and electron

microscopy, 3210

Subject Index 5

Antibody to hapten Stimulation and inhibition of anti-hapten responses in guinea pigs

immunized with hybrid liposomes, 4582 Antibody to interferon

Multiple active sites on human interferons, 4587 Two antigenically distinct species of human interferon, 2185

Antibody to ribonucleic acid, double-stranded Structural features of double-stranded polyribonucleotides required for

immunological specificity and interferon induction, 4564 Antibody to tumor

Enzymatic activation and trapping of luminol-substituted peptides and proteins: Possible means of amplifying cytotoxicity of anti-tumor antibodies, 338

Antigen, allo- Specific human B lymphocyte alloantigens linked to HL-A, 5103

Antigen-antibody complex New complement function: Solubilization of antigen-antibody

aggregates, 418 Antigen, brain

Interspecies brain antigen detected by naturally occurring mouse anti-brain autoantibody, 1036

Antigen, carcinoembryonic Carcinoembryonic antigen: Evidence for multiple antigenic determinants

and isoantigens, 4602 Tumor-associated determinant(s) of carcinoembryonic antigen, 1528

Antigen, cell surface Biochemically differentiated mouse glial lines carrying a nervous system

specific cell surface antigen (NS-1), 1927 Cerebellar cell surface antigens of mouse brain, 4110 New cell surface antigens in rat defined by tumors of the nervous

system, 1296 Thymus-derived rat lymphocyte receptor for cell surface antigens is

nonserologically defined product of major histocompatibility gene complex, 1147

Antigen, crosslinked Antibody to terminal deoxynucleotidyl transferase, 4119

Antigen, histocompatibility see also Histocompatibility Absence of H-2 antigens capable of reacting with cytotoxic T cells on

teratoma line expressing T/t locus antigen, 3661 Enhanced representation of HL-A antigens on human lymphocytes after

mitogenesis induced by phytohemagglutinin or Epstein-Barr virus, 3206

Evolutionary relationship between immunoglobulins and transplantation antigens, 1612

Functional interactions of viral and histocompatibility antigens at tumor cell surfaces, 5066

Immunological and chemical purity of papain-solubilized HL-A antigens, 1594

Specific human B lymphocyte alloantigens linked to HL-A, 5103 Structural similarities between a product of the T/t-locus isolated from

sperm and teratoma cells, and H-2 antigens isolated from splenocytes, 3215

Tyrosine peptide homologies in the HLA antigen system, 5081 Antigenic stimulation

Antigen-stimulated changes in cyclic nucleotide levels in mouse, 2320 Antigen, interferon

Multiple active sites on human interferons, 4587 Antigen, membrane

Antigen mobility in membranes and complement-mediated immune attack, 2483

Somatic hybrid of thymus leukemia (+) and (-) cells forms thymus leukemia antigens but fails to undergo modulation, 1873

Antigen, nervous system specific Biochemically differentiated mouse glial lines carrying a nervous system

specific cell surface antigen (NS-1), 1927 Antigen recognition


Thymus-derived rat lymphocyte receptor for cell surface antigens is nonserologically defined product of major histocompatibility gene complex, 1147

Two stages in lymphocyte mediator production by differential susceptibility to blockade using niridazole, 4569

Antigen response regulation Separation of T cell subpopulations capable of DNA synthesis,

lymphotoxin release, and regulation of antigen and phytohemagglutinin responses on basis of density and adherence properties, 5090

Antigen, tumor see alsol Immune surveillance; Tumor immunology Different responses of lymphoid cells from tumor-bearing as compared to

tumor-immunized mice when sensitized to tumor specific antigens in vitro, 5086

Gene(s) for cell transformation assigned to human chromosome 7 carrying simian virus 40 genome, 1658


Presence of human chromosome 7 carrying simian virus 40 genome in cells of tumors induced by hybrid somatic cells, 1397

T antigen binds to simian virus 40 DNA at the origin of replication, 1605 Thermolabile T (tumor) antigen from cells transformed by

temperature-sensitive mutant of simian virus 40, 4351 Tumor-associated transplantation antigens in immune rejection of mouse

malignant cell hybrids, 2130 Antigen, viral

Functional interactions of viral and histocompatibility antigens at tumor cell surfaces, 5066



6 Subject Index

Partially purified simian virus 40 T antigen interacts with circular viral DNA molecules, 1960

p60 Polypeptide in feline leukemia virus pseudotype of Moloney sarcoma virus with murine leukemia virus p30 antigenic determinants, 2380

Simian virus 40-related antigens in three human meningiomas with defined chromosome loss, 609

Antimitotic agent Colchicine permeation is required for inhibition of concanavalin A

capping in Chinese hamster ovary cells, 4516 Antipsychotic drug

Brain receptors for antipsychotic drugs and dopamine: Direct binding assays, 4376

Antiserum to HL-A Immunological and chemical purity of papain-solubilized HL-A antigens,

1594 Aorta

Changes in cyclic nucleotide metabolism in aorta and heart of neurogenically hypertensive rats: Possible trigger mechanism of hypertension, 2135

Aphagia Somnolence, akinesia, and sensory activation of motivated behavior in

lateral hypothalamic syndrome, 2819 Aplysia californica

Circadian rhythm of neuron R15 of Aplysia californica: In vivo photoentrainment, 2408

Applied biology Oriental fruit fly, Dacus dorsalis, attracted to methyl eugenol and

related olfactory stimulants, 2501 Applied mathematical sciences

Adiabatic evolution of plasma equilibrium, 3789 Topological theorem for nonlinear dynamics in chemical and ecological

networks, 2856 Arabinose

see Operon, arabinose Arachidonic acid

Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2, in epidermis of psoriasis, 5130

Arginine deprivation Oncornavirus-like particles released from arginine-deprived human

lymphoblastoid cell lines, 4592 Aromatic-amino-acid-synthesizing complex

Aggregated multienzyme system influences transient time: Kinetic evidence for compartmentation by aromatic-amino-acid-synthesizing complex of Neurospora crassa, 4218

Arsanilazotyrosine-248-Zn complex Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase

A: Monitor of catalytic events, 3930 Intramolecular arsanilazotyrosine-248.Zn complex of carboxypeptidase

A: Monitor of multiple conformational states in solution, 4356 Artemia salina

Isolation and characterization of two acidic proteins of 60S ribosomes from Artemia salina cysts, 4744

Polypeptide chain initiation in eukaryotes: Initiation factor MP in Artemia salina embryos, 3947

Artery, human umbilical Oxygen and cyclic nucleotides in human umbilical artery, 3883

Arylamine acetyltransferase (EC 2.3.1.5) Beta-adrenergic stimulation of pineal N-acetyltransferase: Adenosine

3':5'-cyclic monophosphate stimulates both RNA and protein synthesis, 2107

Regulation of sensitivity to /-adrenergic stimulation in induction of pineal N-acetyltransferase, 1661

Ascidia Nuclear magnetic resonance spectrum of living tunicate blood cells and

structure of native vanadium chromogen, 2217 Ascites cell, Krebs II, cell-free system

Translation of Rous sarcoma virus RNA in cell-free system from ascites Krebs II cells, 614

Ascorbic acid requirement Further comments on ascorbic acid requirement, 4151

Asilomar conference Summary statement of Asilomar conference on recombinant DNA

molecules, 1981 Aspartate carbamoyltransferase (EC 2.1.3.2)

Quaternary constraint in hybrid of aspartate transcarbamylase containing wild-type and mutant catalytic subunits, 4298

Reversible dissociation of carbamoyl phosphate synthase-aspartate transcarbamoylase-dihydroorotase complex from ovarian eggs of Rana catesbeiana: Effect of uridine triphosphate and other modifiers, 1712

Aspartate kinase (EC 2.7.2.4) Evolution of biosynthetic pathways: Immunological approach, 1268

Aspartate transcarbamylase see Aspartate carbamoyltransferase (EC 2.1.3.2)

Aspartic acid racemization Aspartic acid racemization in tooth enamel from living humans, 2891

Aspiration National Science Foundation: Origins, hopes, and aspirations

(Symposium), 2839 Aspirin

see Acetylsalicylic acid Astronomy

Chronometric cosmology: Preliminaries and redshift-magnitude relation, 2473

Condensation time of solar nebula from extinct 129I in primitive meteorites, 268

Phenomenological analysis of observed relations for low-redshift galaxies, 4691


Solar abundance of platinum, 4193 Astrophysics

Progress and prospects in high energy astrophysics, 4685 Ataxia-telangiectasia

Somatic rearrangement of chromosome 14 in human lymphocytes, 2071 Atmospheric physics

X and Y operators for general linear transport processes, 1210 A-type particle

A-type and C-type particles in cells infected by Rous sarcoma virus, 3706 Auditory physiology

see also Hearing Central connections of receptors on.rotated and exchanged cerci of

crickets, 966 Receptor synapses without synaptic ribbons in cat cochlea, 3599

AUG-substrate analog Affinity labeling of the ribosomal decoding site with an AUG-substrate

analog, 1505 Aurintricarboxylic acid

Binding of ribosomal protein S1 of Escherichia coli to the 3' end of 16S rRNA, 2940

Author index Author index to volume 72 of Proc. Nat; Acad. Sci. USA, 5165

Authors' statement Authors' statement on the isolation of mRNA coding for immunoglobulin

heavy chain, 4679 Chemical nature of transfer factor, 409 Transfer factor: Subcellular component that transmits information for

specific immune responses, 409 Autoantibody


Autoimmune disease Immunological relationship between acetylcholine receptor and thymus:

A possible significance in myasthenia gravis, 1456 Autolysin, pneumococcal

Mechanism of action of penicillin: Triggering of pneumococcal autolytic enzyme by inhibitors of cell wall synthesis, 4162

Automatism Somnolence, akinesia, and sensory activation of motivated behavior in

lateral hypothalamic syndrome, 2819 Automorphic form

Dedekind's n-function and cohomology of infinite dimensional Lie algebras, 2493

Intertwining operators and automorphic forms for the metaplectic group, 1406

Automorphic function Some fundamental groups in arithmetic of algebraic curves over finite

fields, 3281 Automorphy, almost

General almost automorphy, 3815 Autoregulation

Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase, 4844

Auxin see also Gibberellin; Hormone, plant Enhancement of soybean RNA polymerase I by auxin, 69 Enhancement of soybean RNA polymerase I by auxin (correction), 2468 'I'wo responses to auxin separated by cytokinin inhibition, 1822

Avena sativa Reversible redistribution of phytochrome within cell upon conversion to

physiologically active form, 799 Avian myeloblastosis virus

Ability of tryptophan tRNA to hybridize with 35S RNA of avian myeloblastosis virus and to prime reverse transcription in vitro, 2155

Analysis of oncornavirus RNA subunits by electron microscopy, 3716 :321-labeling of ribonucleic acids at 5'-ends after isolation, 314

Avian sarcoma virus see also Rous sarcoma virus; Sarcoma virus

Avian sarcoma virus B-77 Host induced alteration of avian sarcoma virus B-77 genome, 1031

Avian tumor virus Mapping of biological functions on RNA of avian tumor viruses:

Location of regions required for transformation and determination of host range, 4772

Avoidance reaction Reactions of migrating birds to lights and aircraft, 1994

Axon Impulse conduction along central ax(;ns, 5156 Spike-forming model of neural membrane: Computer simulation of some

perfused axon experiments, 4859

Baboon Sequential production of fatty liver, hepatitis, and cirrhosis in

sub-human primates fed ethanol with adequate diets, 437 Bacillus megaterium

Conditions controlling commitment of differentiation in Bacillus megaterium, 4037

Bacillus subtilis Competent Bacillus subtilis cultures synthesize denatured I)NA binding

activity, 323 Electrophoretic separation of Bacillus subtilis genes, 2207 Homologous relationship between thermolysin and neutral protease A of

Bacillus subtilis, 4341 Nonsaturable, homogeneous transport system in Bacillus subtilis:

Genetic, kinetic, and affinity labeling studies, 814 Bacteria

see also individuial species; Mycobacteria; Mycoplasma




Inheritability of plasmids and population dynamics of cultured cells, 4085

Bacterial cohtamination Integration of exogenous bacterial DNA into plant DNA, 2748

Bacteria, tethered Transient response to chemotactic stimuli in Escherichia coli, 3235

Bacteriochlorophyll see Chlorophyll

Bacteriophage assembly Isolation of bacteriophage lambda A-gene protein, 581

Bacteriophage fl Site-specific cleavage of single-stranded DNA by Hemophilus restriction

endonuclease, 2555 Bacteriophage fd

Nucleotide sequence of RNA polymerase binding site from DNA of bacteriophage fd, 737

Nucleotide sequence of RNA polymerase binding site from DNA of bacteriophage fd (correction), 2468

Bacteriophage . Acquisition of determinant for chloramphenicol resistance by coliphage

lambda, 5041 Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal

RNA, and RNA polymerase subunits, 2743 Excision of prophage X in cell-free system, 2188 Genes, restriction sites, and DNA sequences surrounding 6S RNA

template of bacteriophage X, 1817 Genes, restriction sites, and DNA sequences surrounding 6SRNA

template of bacteriophage X (correction), 3753 Gene transfer to human cells: Transducing phage Xplac gene expression

in GMi-gangliosidosis fibroblasts, 3531 Integrative recombination of bacteriophage lambda DNA in vitro, 1072 In vitro construction of bacteriophage X carrying segments of

Escherichia coli chromosome: Selection of hybrids containing DNA ligase gene, 3416

Isolation of bacteriophage lambda A-gene protein, 581 Mechanism of bacteriophage lambda induction: Acquisition of binding

sites for lambda repressor by host DNA, 1973 Mismatch repair in heteroduplex DNA, 2202 Nucleotide sequence of rightward operator of phage X, 1184 X Repressor turns off transcription of its own gene, 4785 Specialized transducing phages for ribosomal protein genes of

Escherichia coli, 6 Transcription termination and late control in phage lambda, 3300 Transposition of R factor genes to bacteriophage X, 3628 Visualization of novel junction in bacteriophage X DNA, 3024

Bacteriophage M13 Asymmetric orientation of phage coat protein in cytoplasmic membrane

of Escherichia coli, 4749 Bacteriophage MS2

3'-Terminal nucleotide sequence (n = 361) of bacteriophage MS2 RNA, 2559

Bacteriophage Mu Influence of insertions on packaging of host sequences covalently linked

to bacteriophage Mu DNA, 4399 Bacteriophage P2

Bacterial mutation blocking P2 phage late gene expression, 2770 Bacteriophage P22

Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins, 2738

Bacteriophage b6 Intermediates in biosynthesis of double-stranded ribonucleic acids of

bacteriophage 06, 849 Bacteriophage 080

Fusion of Escherichia coli lac genes to ara promoter: Bacteriophage mu-1 insertions, 809

Transcription termination and late control in phage lambda, 3300 Use of gene 32 protein staining of single-strand polynucleotides for gene

mapping by electron microscopy: Application to o80d3ilusu+7 system, 4506

Bacteriophage 'X174 Association of <X174 DNA-dependent ATPase activity with .Escherichia

coli protein, replication factor Y, required for in vitro synthesis of qX174 DNA, 3342

DNA replication in vitro starting with an intact OX174 phage, 3863 Recombinant DNA molecules of bacteriophage >X174, 235 <X174 DNA-dependent DNA synthesis in vitro: Requirement for P1 ban

protein in dnaB mutant extracts of Escherichia coli, 3907 Bacteriophage Q,

In vitro addition of polyadenylate sequence to 3' end of phage Qf RNA and biological activity of product, 428

Site-directed mutagenesis: Extracistronic mutation affecting in vitro propagation of bacteriophage Qo RNA, 367

Bacteriophage Q8 replicase De novo production of self-replicating and environmentally adapted

RNA structures by bacteriophage Q# replicase, 162 Minimal requirements for template recognition by bacteriophage Q0

replicase: General RNA-dependent RNA synthesis, 2640 Nucleotide sequence of microvariant RNA: Another small replicating

molecule, 4252 Bacteriophage SPO1

Conversion of Bacillus subtilis RNA polymerase activity in vitro by a protein induced by phage SPO1, 2366

Highly asymmetric transcription by RNA polymerase containing phage-SPOl-induced polypeptides and a new host protein, 1589

Synthesis of specific functional messenger RNA in vitro by phage-SPOl-modified RNA polymerase of Bacillus subtilis, 4886

Bacteriophage T4 Bacteriophage T4 whiskers: Rudimentary environment-sensing device,' 3701

Subject Index 7

Effects of bacteriophage T4-induced modification of Escherichia coli RNA polymerase on gene expression in vitro, 4928

Reconstruction of bacteriophage T4 DNA replication apparatus from purified components: Rolling circle replication following de novo chain initiation on single-stranded circular DNA template, 4800

Repetitive DNA replication of incomplete genomes of phage T4 petite particles, 1734

Three steps in conversion of large precursor RNA into serine and proline transfer RNAs, 1491

T4-induced RNA ligase joins single-stranded oligoribonucleotides, 122 Bacteriophage T5 -

Methionine and formylmethionine specific tRNAs coded by bacteriophage T5, 558

Bacteriophage T7 In vivo and in vitro phosphorylation of DNA-dependent RNA

polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase, 2506

Link between streptomycin and rifampicin mutation, 2084 Mutants of T7 bacteriophage inhibited by lambda prophage, 3642 Nucleotide sequence of RNA polymerase binding site at early T7

promoter, 784 Permeability lesions in male Escherichia coli infected with

bacteriophage T7, 2222 Balbiani rings

Inhibition of Balbiani ring RNA synthesis at initiation level, 947 ban protein, bacteriophage P1

<OX174 DNA-dependent DNA synthesis in vitro: Requirement for P1 ban protein in dnaB mutant extracts of Escherichia coli, 3907

Barbiturate Presynaptit action of barbiturates in frog spinal cord, 1460

Barley see Hordeum vulgare

Base pairing Hydrogen bonding in yeast phenylalanine transfer RNA, 4866 Tertiary hydrogen bonds in solution structure of transfer RNA, 2049

Batrachotoxin Cooperative activation of action potential Na+ ionophore by neurotoxins,

1782 Cooperative activation of action potential Na+ ionophore by neurotoxins

(correction), 3260 B-cell

see Lymphocyte, bone-marrow-derived Bean

see Glycine max; Phaseolus vulgaris Bee

see Lasioglossum zephyrum Behavior

Evolution of social behavior through interpopulation selection, 1199 Normal and mutant thermotaxis in nematode Caenorhabditis elegans,

4061 Play: Early and eternal, 1878

Benz[a]anthracene, 7,12-dimethyl- Metabolic pathways of 7,12-dimethylbenz[a]anthracene in hepatic

microsomes, 2601 Benzene, substituted

Magnetic circular dichroism of molecules in dense media: Relation between magnetic circular dichroism and Hammett's constants, 452

Benzo[a]pyrene Mutagenic and cytotoxic activity of benzo[a]pyrene 4,5-, 7,8-, and

9,10-oxides and the six corresponding phenols, 3176 Position-specific oxygenation of benzo[a]pyrene by different forms of

purified cy/ochromrne P-450 from rabbit liver, 3917 Berovin

Renilla-type luciferin extracted from calcium-activated photoproteins aequorin, mnemiopsin, and berovin, 2530

Bifurcation theory Topological theorem for nonlinear dynamics in chemical and ecological

networks, 2856 Biliprotein

Modification of intensity and direction of electron flow across bileaflet membranes, 3407

Binding protein see Protein, binding

Bioassay General model for nutritional responses of higher organisms, 4327

Biohazard Summary statement of'Asilomar conference on recombinant DNA

molecules, 1981 Biological control of insects

Life history of Coelomomyces psorophorae, 693 Bioluminescence

Bacterial luciferase requires one reduced flavin for light emission, 3374 Chemical nature of bioluminescence systems in coelenterates, 1546 Renilla-type luciferin extracted from calcium-activated photoproteins

aequorin, mnemiopsin, and berovin, 2530 Biopolymer

Applications of natural-abundance nitrogen-15 nuclear magnetic resonance to large biochemically important molecules, 4696

Bioregulation Bioregulation of lysosomal enzyme secretion from human neutrophils:

Roles of guanosine 3':5'-monophosphate and calcium in stimulus-secretion coupling, 108

Biosynthetic pathways Evolution of biosynthetic pathways: Immunological approach, 1268

Biotin enzyme Structural properties of pyruvate carboxylases from chicken liver and

other sources, 4308



8 Subject Index

Birds Reactions of migrating birds to lights and aircraft, 1994 Slow evolutionary loss of potential for interspecific hybridization in

birds: Manifestation of slow regulatory evolution, 200 "Spshing noise": Biological significance of its attraction and

nonattraction by birds, 1411 BK virus

Homology and relationship between genomes of papovaviruses, BK virus and simian virus 40, 2563

Black hole Progress and prospects in high energy astrophysics, 4685

Bladder, toad, urinary Identification of aldosterone-induced proteins in toad's urinary bladder,

4056 Blanus cinereus

Amphisbaenian ear: Blanus cinereus and Diplometopon zarudnyi, 1487 Blastocladiella emersonii

Cyclic nucleotide metabolism coupled to cytodifferentiation of B'lastocladiella emersonii, 442

Blastocyst Immunosurgery of mouse blastocyst, 5099

Blastogenesis Sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated

mouse lymphocytes, 1950 Bleomycin


Blood cell, tunicate Nuclear magnetic resonance spectrum of living tunicate blood cells and

structure of native vanadium chromogen, 2217 Blood coagulation

Activation of bovine factor X (Stuart factor): Conversion of factor Xaa to factor Xa., 3359

Bovine factor X1 (Stuart factor): Amino-acid sequence of heavy chain, 3082

Bovine factor X1 (Stuart factor): Primary structure of light chain, 16 Factor-VIII-related antigen: Multiple molecular forms in human plasma,

5121 Isolation and characterization of vitamin K-dependent region of bovine

blood clotting factor X, 1281 Blood components

Mitogenic activity of blood components: I. Thrombin and prothrombin, 131

Blood flow, cerebral Central noradrenergic regulation of cerebral blood flow and vascular

permeability, 3726 Bloom's syndrome

Retarded rate of DNA chain growth in Bloom's syndrome, 758 Blue dextran-Sepharose

Blue dextran-Sepharose: Affinity column for the dinucleotide fold in proteins, 669

Blue-green alga see Paleopleurocapsa wopfnerii

Body weight Body weight and food intake at early estrus of rats on high-fat diet, 4172

Bohr effect Interaction of hemoglobin with three ligands: Organic phosphates and

Bohr effect, 2465 Bombykol

Correlation of moth sex pheromone activities with molecular characteristics involved in conformers of bombykol and its derivatives, 3337

Bond angle Valence-bond theory of compounds of transition metals, 4200

Bond orbital Valence-bond theory of compounds of transition metals, 4200

Bone Direct identification of the calcium-binding amino acid

,y-carboxyglutamate in mineralized tissue, 3925 Bone marrow

Formation of bone marrow in fibroblast-transformation ossicles, 2212 Origin of hemopoietic stem cells in embryonic bursa of Fabricius and

bone marrow studied through interspecific chimeras, 2701 Origin of hemopoietic stem cells in embryonic bursa of Fabricius and

bone marrow studied through interspecific chimeras (correction), 5164 Borel-Serre compactification

Homology of congruence subgroups and K3(Z), 651 Bose-Einstein statistics

Distributions associated with Bose-Einstein statistics, 1654 Botany

Anticytokinin activity of substituted pyrrolo[2,3-dJpyrimidines, 3508 Breaking of seed dormancy by catalase inhibition, 306 Cell-division factors from Vinca rosea L. crown gall tumor tissue, 1883 Cell-division factors from Vinca rosea L. crown gall tumor tissue

(correction), 3260 General model for osmotic and pressure-induced flow in plant roots,

3114 Life history of Coelomomyces psorophorae, 693 Potential for nitrogen fixation in maize genotypes in Brazil, 2389 Reversible redistribution of phytochrome within cell upon conversion to

physiologically active form, 799 Species richness of parasitic fungi of British trees, 2116 Two responses to auxin separated by cytokinin inhibition, 1822

Bott periodicity Bruhat decomposition for the loop space of compact group: New

approach to results of Bott, 4716 Bradykinin

Mechanism and modification of bradykinin-induced coronary


vasodilation, 2060 Brain


Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro, 2696

Brain tryptophan hydroxylase: Purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain, 3575

Central noradrenergic regulation of cerebral blood flow and vascular permeability, 3726

Cerebellar cell surface antigens of mouse brain, 4110 Changes in relative levels of guanosine-3':5'-monophosphate-dependent


d-Amphetamine disaggregates brain polysomes via a dopaminergic mechanism, 834

Dopamine receptor binding in corpus striatum of mammalian brain, 4655 Effect of hypothalamic deafferentation on thyrotropin-releasing hormone

levels in rat brain, 4177 Brain microvessel

Norepinephrine and related enzymes present in isolated brain microvessels, 4622

Brdicka current Brdicka currents observed with bovine serum albumin and completely

reduced bovine serum albumin in presence of urea, 2044 Effects of tetraalkylammonium salts on Brdicka and presodium currents

of bovine-serum albumin, 2863 Brine shrimp

see Artemia salina Brownian motion

Brownian motion in biological membranes, 3111 Bruhat decomposition

Bruhat decomposition for the loop space of compact group: New approach to results of Bott, 4716

Bufo viridis Genetic variation as a test of natural selection, 2145

Burkitt lymphoblastoid cell line Oncornavirus-like particles released from arginine-deprived human

lymphoblastoid cell lines, 4592 Bursa of Fabricius

Origin of hemopoietic stem cells in embryonic bursa of Fabricius and bone marrow studied through interspecific chimeras, 2701

Origin of hemopoietic stem cells in embryonic bursa of Fabricius and bone marrow studied through interspecific chimeras (correction), 5164

Butyrophenone Dopamine receptor binding in corpus striatum of mammalian brain, 4655

Butyrylcholine, 1-pyrene- 1-Pyrene-butyrylcholine: A fluorescent probe for the cholinergic system,

3097

C(a) test Power of optimal asymptotic tests of composite statistical hypotheses,-

577 Cn+1

Pseudoconformal geometry of hypersurfaces in Cn+l, 2433 Caenorhabditis elegans

Normal and mutant thermotaxis in nematode Caenorhabditis elegans, 4061

Calcification, soft-tissue Atomic structure of intracellular amorphous calcium phosphate deposits,

2088 Calcitonin

Target cells in bone for parathormone and calcitonin are different: Enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces, 3167

Calcium Active transport of calcium in inverted vesicles of Escherichia coli

(correction), 2833 Calcium role in depolarization-secretion coupling: Aequorin study in

squid giant synapse, 187 Contraction of isolated smooth muscle cells by ionophore A23187, 4459 Induction of growth in resting fibroblastic cell cultures by Ca++, 1584 Oxygen and cyclic nucleotides in human umbilical artery, 3883

Calcium binding Amino-acid sequence of parvalbumin from rabbit skeletal muscle, 1309 Calcium-binding protein as calcium-dependent regulator of brain

adenylate cyclase, 64 Direct identification of the calcium-binding amino acid

-y-carboxyglutamate in mineralized tissue, 3925 Isolation and characterization of vitamin K-dependent region of bovine

blood clotting factor X, 1281 Calcium phosphate, amorphous

Atomic structure of intracellular amorphous calcium phosphate deposits, 2088

Calcium uptake Rapid action of pure crystalline le-hydroxy vitamin D3 and

1a,25-dihydroxy vitamin D3 on intestinal calcium uptake, 229 Callinectes sapidus

Atomic structure of intracellular amorphous calcium phosphate deposits, 2088

Calorimetry, differential scanning Apoprotein stability and lipid-protein interactions in human plasma

high density lipoproteins, 4940 cAMP

see Adenosine 3':5'-cyclic monophosphate




Cancer see also specific cancers; cell entries; Tumor Cell-surface-associated nucleic acid in tumorigenic cells made visible

with platinum-pyrimidine complexes by electron microscopy, 928 Detection of carcinogens as mutagens in Salmonella/microsome test:

Assay of 300 chemicals, 5135 Immunological escape mechanism in spontaneously metastasizing

mammary tumors, 1012 Mutation and childhood cancer: Probabilistic model for incidence of

retinoblastoma, 5116 New approach to antifolate treatment of certain cancers as demonstrated

in tissue culture, 4018 Oncornavirus-like particles in human skin cancers, 3697 Simian virus 40-related antigens in three human meningiomas with

defined chromosome loss, 609 Transformation of cultured human embryonic fibroblasts by

oncornavirus-like particles released from human carcinoma cell line, 2794

Cap formation Concanavalin A receptors on surface membrane of lymphocytes from

patients with Hodgkin's disease and other malignant lymphomas, 1046 Functional interactions of viral and histocompatibility antigens at tumor

cell surfaces, 5066 Mobility of cholera toxin receptors on rat lymphocyte membranes, 3844 Modulation of lymphocyte receptor mobility by locally bound

concanavalin A, 1579 Capping, concanavalin A

Colchicine permeation is required for inhibition of concanavalin A capping in Chinese hamster ovary cells, 4516

Membrane-microtubule interactions: Concanavalin A capping induced redistribution of cytoplasmic microtubules and colchicine binding proteins, 4976

Capsid, viral, viscosity Quasi-elastic behavior of solutions of viral capsid and RNA at very low

shearing stresses, 3501 Carbachol


Carbamoyl-phosphate synthase (glutamine) (EC 2.7.2.9) Functional arginyl residues as ATP binding sites of glutamine synthetase

and carbamyl phosphate synthetase, 2616 Reversible dissociation of carbamoyl phosphate synthase-aspartate

transcarbamoylase-dihydroorotase complex from ovarian eggs of Rana catesbeiana: Effect of uridine triphosphate and other modifiers, 1712

Carbamyl phosphate synthetase see Carbamoyl-phosphate synthase (glutamine) (EC 2.7.2.9)

Carbodiimide Reversible effects of chaotropic agents on proton permeability of

Escheirichia coli membrane vesicles, 3387 Carbohydrate

Antibodies reactive with cell surface carbohydrates, 1127 Mutant hamster cells exhibiting pleiotropic effect on carbohydrate

metabolism, 469 Tumor-associated determinant(s) of carcinoembryonic antigen, 1528

Carbonaceous matter Nonprevalence of biochemical fossils in kerogen from pre-Phanerozoic

sediments, 4706 Carbonate dehydratase B (EC 4.2.1.1)

13C nuclear magnetic resonance studies on mechanism of action of carbonic anhydrase, 454

Crystal structure of human erythrocyte carbonic anhydrase B: Three-dimensional structure at nominal 2.2-A resolution, 51

Carbon-13 enrichment 13C-nuclear magnetic resonance study of [85% 13C-enriched

proline]thyrotropin releasing factor: 13C-13C vicinal coupling constants and conformation of proline residue, 4948

Carbonic anhydrase see Carbonate dehydratase (EC 4.2.1.1)

Carbon monoxide binding Kinetics of binding of carbon monoxide to Lumbricus erythrocruorin: A

possible model, 4313 Oxygen and carbon monoxide binding to synthetic analogs of myoglobin

and hemoglobin active sites, 1166 Carbonyl compound

Radical mechanisms for 1,5-dihydroflavin reduction of carbonyl compounds, 1763

Carbonyl group Donor properties of the three carbonyl groups of chlorophyll a: Ab initio

calculations and 13C magnetic resonance studies, 2873 -y-Carboxyglutamate

Direct identification of the calcium-binding amino acid -y-carboxyglutamate in mineralized tissue, 3925

Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X, 1281

Carboxypeptidase A Intramolecular arsanilazotyrosine-248.Zn complex of carboxypeptidase

A: Monitor of catalytic events, 3930 Intramolecular arsanilazotyrosine-248.Zn complex of carboxypeptidase

A: Monitor of multiple conformational states in solution, 4356 Carboxypeptidase B (EC 3.4.12.3)

Amino-acid sequence of bovine carboxypeptidase B, 1666 Carcinogen, chemical

Carcinogens as mutagens: Bacterial tester strains with R factor plasmids, 979

Changes of tissue water proton relaxation rates during early phases of chemical carcinogenesis, 56

Chemical induction of sperm abnormalities in mice, 4425

Subject Index 9

Detection of carcinogens as mutagens in Salmonella/microsome test: Assay of 300 chemicals, 5135

Hair dyes are mutagenic: Identification of a variety of mutagenic ingredients, 2423

Metabolic pathways of 7,12-dimethylbenz[ajanthracene in hepatic microsomes, 2601

Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide, 3190

Position-specific oxygenation of benzo[a]pyrene by different forms of purified cytochrome P-450 from rabbit liver, 3917

Salmonella mutants associated with germfree rats: Site specific model to detect carcinogens as mutagens, 4607

Temperature-sensitive mutants of chemically transformed epithelial cells, 214

Cardiac ultrastructure Fetal mouse hearts: Model for studying ischemia, 2809 Fetal mouse hearts: Model for studying ischemia (correction), 4679

Cardiolipin Antigen mobility in membranes and complement-mediated immune

attack, 2483 Carnitine acylcarnitine translocase

Mitochondrial carnitine acylcarnitine translocase system, 883 Carnitine palmitoyltransferase (EC 2.3.1.21)

Role of carnitine in hepatic ketogenesis, 4385 Cartan connection

Pseudoconformal geometry of hypersurfaces in C n+1, 2433 Cartilage

Carbon-13 nuclear magnetic resonance study of chondroitin 4-sulfate in proteoglycan of bovine nasal cartilage, 3421

Plasmin digests of S-carbamidomethylated human growth hormone, 1684 Casein

Substrate specificity of cyclic AMP-dependent protein kinase, 3448 Castration

Effect of castration and testosterone replacement on circadian pacemaker in mice (Mus musculus), 3744

Catabolite gene activator protein Initiation of in vitro mRNA synthesis from wild-type lac promoter, 4394

Catabolite repression Adenosine 3':5'-cyclic monophosphate as mediator of catabolite

repression in Escherichia coli, 2300 Catalase (EC 1.11.1.6)

Breaking of seed dormancy by catalase inhibition, 306 Catalepsy

Somnolence, akinesia, and sensory activation of motivated behavior in lateral hypothalamic syndrome, 2819

Catalysis see also Enzyme Activation volumes in enzymic catalysis: Their sources and modification

by low-molecular-weight solutes, 3014 Catalysis by acetylcholinesterase: Evidence that the rate-limiting step for

acylation with certain substrates precedes general acid-base catalysis, 3834

Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase A: Monitor of catalytic events, 3930


Catalytic subunit Quaternary constraint in hybrid of aspartate transcarbamylase

containing wild-type and mutant catalytic subunits, 4298 Catecholamine



Dopamine receptor binding in corpus striatum of mammalian brain, 4655 Fatty acids as modulators of membrane functions:

Catecholamine-activated adenylate cyclase of turkey erythrocyte, 3433 Regulation of sensitivity to 3-adrenergic stimulation in induction of

pineal N-acetyltransferase, 1661 Stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol:

Effect of cholera toxin, 3561 Ultrastructural localization of tyrosine hydroxylase in noradrenergic

neurons of brain, 659 Catecholamine synthesis


Memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis, 4660

Cauchy-Szego integral Necessary and sufficient conditions for solvability of Lewy equation,

3287 Caudate nucleus


Caulobacter crescentus Poly(adenylic acid) sequences in the RNA of Caulobacter crescentus,

2343 C3 convertase

Properdin: Initiation of alternative complement pathway, 3220 Cell

see also specific cells; Transformed animal cell Cell, adenocarcinoma

Transformation of cultured human embryonic fibroblasts by oncornavirus-like particles released from human carcinoma cell line, 2794



10 Subject Index

Cell adhesion Major cell surface glycoprotein of chick embryo fibroblasts is an

agglutinin, 3158 Separation of T cell subpopulations capable of DNA synthesis,


Cell-aggregating factor Purification and characterization of retina-specific cell-aggregating

factor, 916 Cell aggregation

Genetic complexity of aggregation in cellular slime mold Polysphondylium violaceum, 1041

Physiological role of an endoperoxide in human platelets: Hemostatic defect due to platelet cyclo-oxygenase deficiency, 1446


Synthesis and biological properties of 9,11-azo-prostanoid: Highly active biochemical mimic of prostaglandin endoperoxides, 3355

Cell, ascites tumor Cholera toxin activation of adenylate cyclase in cancer cell membrane

fragments, 2572 Cycle of deprotonation and reprotonation energizing amino-acid

transport? 23 On alleged high sensitivity of mouse Ehrlich-Lettre ascites tumor cells to

diphtheria toxin, 3149 Cell, bone

Target cells in bone for parathormone and calcitonin are different: Enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces, 3167

Cell, bone-marrow-derived see Lymphocyte, bone-marrow-derived

Cell, chick embryo Interferon action: II. Membrane-bound alkaline ribonuclease activity in

chick embryo cells manifesting interferon-mediated interference, 182 Cell, Chinese hamster ovary


Cell culture see also Methodology (culturing)

Cell culture, bone marrow Growth of mouse megakaryocyte colonies in vitro, 1744 Oncornavirus-like particles from cultured bone marrow cells preceding

leukemia and malignant histiocytosis, 2804 Cell culture, fibroblast


Induction of growth in resting fibroblastic cell cultures by Ca++, 1584 Cell culture, heart

Lack of detectable change in cyclic AMP during cardiac inotropic response to isoproterenol immobilized on glass beads, 824

Cell culture, mammalian Mucopolysaccharides associated with nuclei of cultured mammalian cells,

2032 Cell culture, synchronous

Distribution and virogenic effects of 5-bromodeoxyuridine in synchronized rat embryo cells, 1829

Cell cycle Cell cycle specific fluctuations in adenosine 3':5'-cyclic monophosphate

and polyamines of Chinese hamster cells, 1482 Cell cycle studies of mononucleate and cytochalasin-B-induced

binucleate fibroblasts, 869 Cyclic AMP, nonessential regulator of cell cycle, 878 Erythroid differentiation induced by dimethylsulfoxide in cells infected

with Friend virus: Relationship to cell cycle, 28 Selective killing of transformed baby hamster kidney (BHK) cells, 4994 Transformation by polyoma virus alters expression of cell mutation

affecting cycle traverse, 2540 Cell death

Ectopic neurons and aberrant connections during neural development, 4455

Cell density Separation of T cell subpopulations capable of DNA synthesis,


Cell division see also Cell growth; Cell proliferation Changing patterns of actin localization during cell division, 1913 Early effect of interferon on mouse leukemia cells cultivated in

chemostat, 2265 Cell-division factor

Cell-division factors from Vinca rosea L. crown gall tumor tissue, 1883 Cell-divisian factors from Vinca rosea L. crown gall tumor tissue

(correction), 3260 Cell, embryonic chicken liver

Synthesis and differentiation of plasma proteins in cultured embryonic chicken liver cells: System for study of regulation of protein synthesis, 5007

Cell, enucleate RNAs of simian virus 40 in productively infected monkey cells: Kinetics

of formation and decay in enucleate cells, 2587 Cell, epithelial

Establishment of tight junctions between epithelial cells, 2711 Temperature-sensitive mutants of chemically transformed epithelial

cells, 214 Cell, erythroid

Testosterone stimulation of rapidly labeled, low-molecular-weight RNA


fraction in human hepatic erythroid cells in culture, 523 Cell, erythroleukemic

Differentiation in erythroleukemic cells and their somatic hybrids, 98 Hemoglobin synthesis in somatic cell hybrids: Globin gene expression in

hybrids between mouse erythroleukemia and human marrow cells or fibroblasts, 1102

Induction of erythroid differentiation in murine virus infected erythroleukemia cells by highly polar compounds, 1003

Purine metabolism in murine virus-induced erythroleukemic cells during differentiation in vitro, 1630

Cell fusion Biochemical lesions used for selection of human cells with hybrid

cytoplasms, 1812 Cell, glioma


Cell growth see also Cell division; Cell proliferation Aging and its relation to cell growth and differentiation in Drosophila

imaginal discs: Developmental response to growth restricting conditions, 4674

Control of ovarian cell growth in culture by serum and pituitary factors, 483


Effect of growth conditions on DNA-membrane attachment in Escherichia coli, 2446

Gibberellic-acid-induced cell elongation in lettuce hypocotyls, 1107 Growth-dependent alterations in oligomannosyl cores of glycopeptides,

3139 Induction of growth in resting fibroblastic cell cultures by Ca++, 1584 Inherited "neoplasm" in a fungus, 4626 Regulation of RNA polymerase synthesis in Escherichia coli: Mutant

unable to synthesize enzyme at 43?, 911 Transformation by polyoma virus alters expression of cell mutation

affecting cycle traverse, 2540 Cell, HeLa

Microtubule phosphorylation during cell cycle of HeLa cells, 1161 Model for compartmentation of de novo and salvage thymidine

nucleotide pools in mammalian cells, 3333 Synthesis of RNA containing a methylated blocked 5' terminus by HeLa

nuclear homogenates, 2930 Cell, hematopoietic

Origin of hemopoietic stem cells in embryonic bursa of Fabricius and bone marrow studied through interspecific chimeras, 2701

Origin of hemopoietic stem cells in embryonic bursa of Fabricius and bone marrow studied through interspecific chimeras (correction), 5164

Sulfhydryl dependence in primary explant hematopoietic cells: Inhibition of growth in vitro with vitamin B12 compounds, 73

Cell, hepatoma DNA polymerase stimulated by factors isolated from Novikoff hepatoma,

1171 Influence of novel hypophyseal factor on steroid metabolism in cultured

hepatoma cells, 4986 Kinetics of steroid induction and deinduction of tyrosine

aminotransferase synthesis in cultured hepatoma cells, 2007 Cell, hybrid

see Hybrid cell Cell, leukemia

Early effect of interferon on mouse leukemia cells cultivated in chemostat, 2265

Lysis of leukemia cells by spleen cells of normal mice, 2780 Somatic hybrid of thymus leukemia (+) and (-) cells forms thymus

leukemia antigens but fails to undergo modulation, 1873 Viral-related information in oncornavirus-like particles isolated from

cultures of marrow cells from leukemic patients in relapse and remission, 623

Cell, lymphoid Different responses of lymphoid cells from tumor-bearing as compared to

tumor-immunized mice when sensitized to tumor specific antigens in vitro, 5086

Growth characteristics of Epstein-Barr virus (EBV)-genome-negative lymphoma line and its EBV-converted subline in vitro, 3518

In vitro infection of lymphoid cells by thymotropic radiation leukemia virus grown in vitro, 3546

Cell, mammalian Isolation of mammalian cell mutants deficient in glucose-6-phosphate

dehydrogenase activity: Linkage to hypoxanthine phosphoribosyltransferase, 493

Relationship between in vivo degradative rates and isoelectric points of proteins, 3893

Cell, melanoma Correlated suppression by 5-bromodeoxyuridine of tumorigenicity and

plasminogen activator in mouse melanoma cells, 47 Melanoma cells resistant to inhibition of growth by melanocyte

stimulating hormone, 951 Cell, mesodermal

Poly(ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb, 1852

Cell morphology Induction of growth in resting fibroblastic cell cultures by Ca++, 1584 Ultrastructural localization of insulin receptors on adipocytes, 3526

Cell, muscle Contraction of isolated smooth muscle cells by ionophore A23187, 4459

Cell, myogenic and nonmyogenic Differences among myosins synthesized in non-myogenic cells,

presumptive myoblasts, and myoblasts, 4999




Cell, neuroblastoma Cyclic AMP-mediated induction of ornithine decarboxylase of glioma

and neuroblastoma cells, 3087 Gene expression in mouse neuroblastoma cells: Properties of the genome,

3119 Nerve growth factor secreted by mouse neuroblastoma cells in culture,

1895 Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma

cells, 3472 Regulation of protein synthesis at translational level in neuroblastoma

cells, 2289 Cell, normal and transformed

Cytoplasmic microtubules in normal and transformed cells in culture: Analysis by tubulin antibody immunofluorescence, 4981

Cell patching and capping Functional interactions of viral and histocompatibility antigens at tumor

cell surfaces, 5066 Cell, pluripotent

Differentiation of clonal lines of teratocarcinoma cells: Formation of embryoid bodies in vitro, 1441

Cell proliferation see also Cell division; Cell growth Effect of chromosomal proteins extractable with low concentrations of

NaCl on chromatin structure of resting and proliferating cells, 2361 Increased cellular levels of spermidine or spermine are required for

optimal DNA synthesis in lymphocytes activated by concanavalin A, 4042

Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2a, 2724

Stimulus to DNA synthesis in cultures of chick embryo cells is nonspecific, 1676

Surface proteins in cell proliferation as studied with thrombin and other proteases, 413

Cell, Raji Epstein-Barr virus genomes with properties of circular DNA molecules

in carrier cells, 1477 Cell recognition

Cell-cell interactions: Enhancement of glycosyl transferase ectoenzyme systems during Chlamydomonas gametic contact, 310

Cell surface species-specific high affinity receptors for discoidin: Developmental regulation in Dictyostelium discoideum, 3541

Purification and characterization of retina-specific cell-aggregating factor, 9L6

Temporal changes in tectal cell surface specificity induced by nerve growth factor, 4270

Cell, retina Purification and characterization of retina-specific cell-aggregating

factor, 916 Cell, senescent

Removal of senescent cells by human macrophages in situ, 3521 Cell, Sertoli


Follicle-stimulating hormone stimulates estradiol-17f synthesis in cultured Sertoli cells, 2677

Cell, spleen, mouse Lysis of leukemia cells by spleen cells of normal mice, 2780

Cell surface see also Membrane Appearance of smaller mannosyl-glycopeptides on surface of a human

cell transformed by simian virus 40, 2687 Contact inhibition of phagocytosis in epithelial sheets: Alterations of cell

surface properties induced by cell-cell contacts, 719 Cyclic AMP modulates microvillus formation and agglutinability in

transformed and normal mouse fibroblasts, 1263 Genetic analysis of cell surface: Association of human chromosome 5

with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids, 2237

Growth-dependent alterations in oligomannosyl cores of glycopeptides, 3139

Release of surface proteins and metabolic activation of sea urchin eggs at fertilization, 4474

Surface ruffles as markers for studies of cell transformation by Rous sarcoma virus, 3144


Turning on of activities in unfertilized sea urchin eggs: Correlation with changes of surface, 4469

Cell surface carbohydrate Antibodies reactive with cell surface carbohydrates, 1127

Cell surface of tumor Functional interactions of viral and histocompatibility antigens at tumor

cell surfaces, 5066 Cell surface protein

Major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin, 3158


Cell, 3T3 Distribution of membrane particles and gap junctions in normal and

transformed 3T3 cells studied in situ, in suspension, and treated with concanavalin A, 572

Isolation of cationic polypeptide from human serum that stimulates proliferation of 3T3 cells, 2635

Serum rapidly stimulates ouabain-sensitive 86Rb+ influx in quiescent 3T3 cells, 4492

Cell, teratocarcinoma Differentiation of clonal lines of teratocarcinoma cells: Formation of

Subject Index 11

embryoid bodies in vitro, 1441 Normal genetically mosaic mice produced from malignant

teratocarcinoma cells, 3585 Cell, teratoma

Absence of H-2 antigens capable of reacting with cytotoxic T cells on teratoma line expressing Tit locus antigen, 3661

Cell, thymus Immunosuppressive effect of syngeneic thymus cells on allograft

rejection, 2371 Cell, thymus-derived

see also Lymphocyte, thymus-derived Activation of T and B lymphocytes in vitro: Presence of fi2-microglobulin

determinants on allogeneic effect factor, 4577 Binding of autologous erythrocytes to immature T-cells, 3201 H-2 gene complex restricts transfer of delayed-type hypersensitivity in

mice, 5095 Idiotype positive T cells visualized by autoradiography and electron

microscopy, 3210 Induction of immune response through interaction of helper cells with

immune complex bound to surface of B cells, 4555 Separation of T cell subpopulations capable of DNA synthesis,


Cell, trophoblastic Immunosurgery of mouse blastocyst, 5099

Cell, tumor Unique complement-derived chemotactic factor for tumor cells, 4128

Cell, tumorigenic Cell-surface-associated nucleic acid in tumorigenic cells made visible

with platinum-pyrimidine complexes by electron microscopy, 928 Cellular engineering

Protection of lethally irradiated mice with allogeneic fetal liver cells: Influence of irradiation dose on immunologic reconstitution, 4100

Cell wall synthesis Mechanism of action of penicillin: Triggering of pneumococcal autolytic

enzyme by inhibitors of cell wall synthesis, 4162 Ceramic material

Properties of molten magnesium oxide, 1026 Cercus


Cerebellar mutant Cerebellar cell surface antigens of mouse brain, 4110

cGMP see Guanosine 3':5'-cyclic monophosphate

Chaotropic agent Reversible effects of chaotropic agents on proton permeability of

Escherichia coli membrane vesicles, 3387 Charge pairing

Physical basis of charge pairing in mitochondria, 2058 Charge separation

Primary charge separation in bacterial photosynthesis: Oxidized chlorophylls and reduced pheophytin, 4956

Charge transfer Raman resonance of electron donor/acceptor complexes, 4196 Rate processes and compensation rule, 999

Chemical network Topological theorem for nonlinear dynamics in chemical and ecological

networks, 2856 Chemical reaction, fall-off from extrapolated values

Fall-off from extrapolated values of all chemical reactions at very high temperatures, 1717

Chemical shift Applications of natural-abundance nitrogen-15 nuclear magnetic

resonance to large biochemically important molecules, 4696 Chemicals, screening


Chemistry Abiotic, graphitic microstructures in micaceous metaquartzite about

3760 million years old from Southwestern Greenland: Early Precambrian microfossils, 1206

Absence of interference in photoexcitation of triplets, 4203 Acid-base properties, hydrolytic mechanism, and susceptibility to 02

oxidation of Fe4S4(SR)4-2 clusters, 231 Algebraic description of stereochemical correspondence, 2385 Antagonistic effect of an inhalation anesthetic and high pressure on




Assessment of some problems associated with prediction of three-dimensional structure of a protein from its amino-acid sequence, 1221



Collisional energy transfer and quenching of electronic excitation, 4205 Concerning Jahn-Teller effects, 2104 Conjugated polyene fatty acids as membrane probes, 1649 Decomposition of hydrogen peroxide catalyzed by ferric

ethylenediaminetetraacetate complex, 140 Distribution of end-to-end distances of oligopeptide in solution

estimated by energy transfer, 1807



12 Subject Index

Donor properties of the three carbonyl groups of chlorophyll a: Ab initio calculations and 13C magnetic resonance studies, 2873

Effects of tetraalkylammonium salts on Brdicka and presodium currents of bovine-serum albumin, 2863

Empirical'intermolecular and conformational potential energy functions: II. Crystal packing, rotational barriers, and conformational analysis, 854


Insertion compounds of 2H-TaS2-NH3, 464 Iron-sulfur clusters: Ligand exchange kinetics studied on water-soluble

Fe4S4(SR)4n- cluster, 2478 Magnetic circular dichroism of molecules in dense media: Relation

between magnetic circular dichroism and Hammett's constants, 452 Magnetic resonance spectra of membranes, 1451 Matrix method for fluctuations and noise in kinetic systems, 3807 Maximum-valence radii of transition metals, 3799 Model for hydrogen bond, 4701 Model of protein folding: Inclusion of short-, medium-, and long-range

interactions, 3802 New approach to empirical intermolecular and conformational potential

energy functions: I. Description of model and derivation of parameters, 543


Oxygen and carbon monoxide binding to synthetic analogs of myoglobin and hemoglobin active sites, 1166

Ozone model for bonding of 02 to heme in oxyhemoglobin, 2335 Photooxidation of chlorins by quinones studied by nuclear magnetic

resonance techniques, 3265 Properties of molten magnesium oxide, 1026 Radical mechanisms for 1,5-dihydroflavin reduction of carbonyl

compounds, 1763 Raman resonance of electron donor/acceptor complexes, 4196 Reaction of tris(bipyridine)ruthenium(III) with hydroxide and its

application in a solar energy storage system, 2858 Resonance Raman spectra of manganese(III) tetraphenylporphin halides,

433 Sidechain torsional potentials and motion of amino acids in proteins:

Bovine pancreatic trypsin inhibitor, 2002 Stereochemistry of decarboxylation of trans-4-hydroxycinnamic acid by

Aerobacter, 1681 Synthetic analogs of active sites of iron-sulfur proteins:


Theoretical studies of metal-phosphate interactions, 3794 Triplet state in bacterial photosynthesis: Possible mechanisms of

primary photo-act, 3270 Valence-bond theory of compounds of transition metals, 4200

Chemoattractant N-Formylmethionyl peptides as chemoattractants for leucocytes, 1059

Chemoreceptor Chemoreceptors and feeding in calanoid copepods (Arthropoda:

Crustacea), 4185 Chemostat

Early effect of interferon on mouse leukemia cells cultivated in chemostat, 2265

Chemotaxis Chemotactic signals induce cell differentiation in Dictyostelium

discoideum, 3163 Normal and mutant thermotaxis in nematode Caenorhabditis elegans,

4061 Purification and synthesis of eosinophilotactic tetrapeptides of human



Unique complement-derived chemotactic factor for tumor cells, 4128 Chemotaxis, bacterial

Methionine in bacterial chemotaxis: Requirement for tumbling and involvement in information processing, 4640

Methylation of a membrane protein involved in bacterial chemotaxis, 3939

Quantitation of sensory response in bacterial chemotaxis, 710 Significance of retention of ligand by protein, 2120 Transient response to chemotactic stimuli in Escherichia coli, 3235

Chemotherapy New approach to antifolate treatment of certain cancers as demonstrated

in tissue culture, 4018 Selective killing of transformed baby hamster kidney (BHK) cells, 4994 Solid tumor models for assessment of different treatment modalities:

Radiation-induced changes in growth rate characteristics of solid tumor model, 2662


Chimera, embryonic Origin of hemopoietic stem cells in embryonic bursa of Fabricius and


bone marrow studied through interspecific chimeras (correction), 5164 Chimera, interspecific

Cholinergic differentiation of presumptive adrenergic neuroblasts in interspecific chimeras after heterotopic transplantations, 728

Chiral symmetry Pion spectrum in decay of 4(3.7) to t(3.1), 4216

Chitin biosynthesis Microfibril assembly by granules of chitin synthetase, 2706


Chitin synthase (EC 2.4.1.16) Chitin synthetase zymogen is attached to yeast plasma membrane, 3952 Microfibril assembly by granules of chitin synthetase, 2706

Chlamydomonas Cell-cell interactions: Enhancement of glycosyl transferase ectoenzyme

systems during Chlamydomonas gametic contact, 310 Selection for conditional gametogenesis in Chlamydomonas reinhardi,

3652 Thylakoid membrane polypeptides of Chlamydomonas reinhardtii:

Wild-type and mutant strains deficient in photosystem II reaction center, 2175

Chloramphenicol Acquisition of determinant for chloramphenicol resistance by coliphage

lambda, 5041 Cellular protein synthesis required in reversal of

ethidium-bromide-induced inhibition of cell transformation by murine sarcoma virus, 4337

R-factor replication in presence of chloramphenicol, 654 Chloroacetaldehyde


Chlorophyll Biosynthesis of /-aminolevulinic acid from intact carbon skeleton of

glutamic acid in greening barley, 2719 Donor properties of the three carbonyl groups of chlorophyll a: Ab initio

calculations and 13C magnetic resonance studies, 2873 Modification of intensity and direction of electron flow across bileaflet

membranes, 3407 Photooxidation of chlorins by quinones studied by nuclear magnetic

resonance techniques, 3265 Picosecond detection of intermediate in photochemical reaction of

bacterial photosynthesis, 2251 Primary charge separation in bacterial photosynthesis: Oxidized

chlorophylls and reduced pheophytin, 4956 Triplet state in bacterial photosynthesis: Possible mechanisms of

primary photo-act, 3270 Chloroplast

Light-dependent absorption and selective scattering changes at 518 nm in chloroplast thylakoid membranes, 3858

Phylogenetic origin of chloroplast and prokaryotic nature of its ribosomal RNA, 2418

Prokaryotic nature of red algal chloroplasts, 2310 Stabilization of electron spin resonance probes for photosynthesis

studies, 3107 Chlorpromazine

Phenothiazine drugs: Structure-activity relationships explained by conformation that mimics dopamine, 1899

Cholecalciferol see Vitamin D

Choleragen see Toxin, cholera

Cholesterol Antigen mobility in membranes and complement-mediated immune

attack, 2483 Cholesterol synthesis in man measured by isotope kinetics of squalene,

4612 Genetic heterogeneity in familial hypercholesterolemia: Two different

mutations affecting functions of low-density lipoprotein receptor, 1092 Headgroup conformation and lipid-cholesterol association in

phosphatidylcholine vesicles: 31Pj{1H1 nuclear Overhauser effect, 3477 Cholesterol esters

Receptor-dependent hydrolysis of cholesterol esters contained in plasma low density lipoprotein, 2925

Cholinergic system 1-Pyrene-butyrylcholine: A fluorescent probe for the cholinergic system,

3097 Chondrocyte, chick

Changes in collagen biosynthesis that occur when chick chondrocytes are grown in 5-bromo-2'-deoxyuridine, 4511

Chondroitin sulfate Carbon-13 nuclear magnetic resonance study of chondroitin 4-sulfate in

proteoglycan of bovine nasal cartilage, 3421 Mucopolysaccharides associated with nuclei of cultured mammalian cells,

2032 Chromatic polynomial

Limits of zeroes of recursively defined polynomials, 4209 Chromatid exchanges and breaks

Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia, 4066

Chromatin see also Histone Absence of histone Fl in mitotically dividing, genetically inactive

nucleus, 2672 Chemical and physical properties of fractionated chromatin, 3328 Chromatin and DNA synthesis associated with nuclear membrane in

germinating cotton, 3134 Chromatin as template for RNA synthesis in vitro. 194 Chromatin directed transcription of 5S and tRNA genes, 1082 Effect of chromosomal proteins extractable with low concentrations of

NaCl on chromatin structure of resting and proliferating cells, 2361 Estradiol-17/3 affects synthesis of specific uterine nonhistone

chromosomal proteins, 4346 Estrogen affects gene expression in chick oviduct: Nuclear receptor levels

and initiation of transcription, 4228 Gene expression in mouse neuroblastoma cells: Properties of the genome,

3119




Major nonhistone proteins of rat liver chromatin: Preliminary identification of myosin, actin, tubulin, and tropomyosin, 3902

Nuclear receptors for thyroid hormone: Nonrandom distribution within chromatin, 1787

Nuclease action on chromatin: Evidence for discrete, repeated nucleoprotein units along chromatin fibrils, 633

Separation of lymphocyte chromatin into template-active fractions with specificity for eukaryotic RNA polymerase II or prokaryotic RNA polymerase, 4830

Strand-selective transcription of globin genes in rabbit erythroid cells and chromatin, 4835

Chromatin structure Chromatin architecture: Investigation of subunit of chromatin by dark

field electron microscopy, 2691 Discrete subunits released after nuclease and trypsin digestion of

chromatin, 1212 Electron microscopy of defined lengths of chromatin, 3320 Folding of DNA double helix in chromatin-like structures from simian

virus 40, 1843 Histone-histone propinquity by aldehyde fixation of chromatin, 1304 Interaction of fl histone with superhelical DNA, 2597 Location of histones on simian virus 40 DNA, 2895 Octamer of histones in chromatin and free in solution, 2626 Quaternary structure of chromatin, 1043 Structure of transcriptionally active chromatin, 4404

Chromatin subunit Analysis of DNA of isolated chromatin subunits, 3978 Structure of transcriptionally active chromatin, 4404 Subunit structure of naturally occurring chromatin lacking histones Fl

and F3, 3536 Chromatography, affinity


,f--Galactoside binding protein from electric organ tissue of Electrophorus electricus, 1383

Isolation of antibodies specific to sickle hemoglobin by affinity chromatography using a synthetic peptide, 4759

Isolation of rabbit reticulocyte initiation factors by means of heparin bound to Sepharose, 2352

Method for the isolation of specific tRNA precursors, 4790 Multiple active sites on human interferons, 4587 Partial purification of glucocorticoid receptor, 3849 Statistical theory of chromatography: New outlooks for affinity

chromatography, 4840 Synthesis of acetylcholine receptor by denervated rat diaphragm muscle,

1368 Synthesis of acetylcholine receptor during differentiation of cultured

embryonic muscle cells, 4028 Chromatography, covalent

Rapid and specific method for isolation of thiol-containing peptides from large proteins by thiol-disulfide exchange on solid support, 3029

Chromatography, high pressure liquid Metabolic pathways of 7,12-dimethylbenz[a]anthracene in hopatic

microsomes, 2601 Chromatography, reverse phase

Separation of transfer ribonucleic acid by Sepharose chromatography using reverse salt gradients, 1068

Chromatography, statistical theory Statistical theory of chromatography: New outlooks for affinity

chromatography, 4840 Chromosomal analysis

Analysis of incipient reproductive isolation within species of Drosophila, 3638

Chromosomal movement Presence of actin during chromosomal movement, 2451

Chromosomal protein Effect of chromosomal proteins extractable with low concentrations of

NaCl on chromatin structure of resting and proliferating cells, 2361 Chromosomal protein, nonhistone

Estradiol-17fl affects synthesis of specific uterine nonhistone chromosomal proteins, 4346

Gene expression in mouse neuroblastoma cells: Properties of the genome, 3119

Selective effects of inhibitors of protein synthesis on metabolism of nuclear and cytoplasmic proteins: Coordinate synthesis of nonhistone chromosomal proteins, 4450

Chromosomal similarity Allozymic and chromosomal similarity in two Drosophila species, 4521

Chromosome Assembly of microtubules onto kinetochores of isolated mitotic

chromosomes of HeLa cells, 4023 Chromosome measurement and sorting by flow systems, 1231 Effect of growth conditions on DNA-membrane attachment in

Escherichia coli, 2446 Histone-histone propinquity by aldehyde fixation of chromatin, 1304 Parallel changes in puffing activity and patterns of protein synthesis in

salivary glands of Drosophila, 3604 Chromosome abnormalities

Nonrandom chromosomal abnormalities in hematologic disorders of man, 152

Chromosome, dinoflagellate Genetic analysis in dinoflagellate Crypthecodinium (Gyrodinium)

cohnii: Unusual meiosis, 4546 Chromosome, Drosophila


Subject Index 13

Chromosome, human Chromosomal localization of human genes governing interferon-induced

antiviral state, 3129 Gene dosage: Assignment of erythrocyte acid phosphatase locus to

chromosome 2, 4526 Gene(s) for cell transformation assigned to human chromosome 7

carrying simian virus 40 genome, 1658 Genetic analysis of cell surface: Association of human chromosome 5


Human gene expression in rodent cells after uptake of isolated metaphase chromosomes, 1797

Human RNA transcripts among heterogeneous nuclear RNA from man-mouse somatic cell hybrids, 1868

Human X-linked genes regionally mapped utilizing X-autosome translocations and somatic cell hybrids, 2125

Localization of cytoplasmic-membrane-associated DNA in human chromosomes, 5004

Localized derepression on the human inactive X chromosome in mouse-human cell hybrids, 1510



Simian virus 40-related antigens in three human pieningiomas with defined chromosome loss, 609

Somatic rearrangement of chromosome 14 in human lymphocytes, 2071 Tay-Sachs' and Sandhoffs diseases: Assignment of genes for

hexosaminidase A and B to individual human chromosomes, 263 Transfer of human gene for hypoxanthine-guanine

phosphoribosyltransferase via isolated human metaphase chromosomes into mouse L-cells, 1792

Chromosome, mouse Trisomy of chromosome 15 in spontaneous leukemia of AKR mice, 1515

Chromosome puff Chromosome puff activity and protein synthesis in larval salivary glands

of Drosophila melanogaster, 4550 Parallel changes in puffing activity and patterns of protein synthesis in

salivary glands of Drosophila, 3604 RNA from heat-induced polysomes at puff sites in Drosophila

melanogaster, 1117 Chromosome rearrangement, somatic

Somatic rearrangement of chromosome 14 in human lymphocytes, 2071 Chromosome replication

Deposition of histones onto replicating chromosomes, 4440 Presynaptic events in meiocytes of Lilium longiflorum and relation to

crossing-over: A preselection hypothesis, 961 Chromosome sorting

Chromosome measurement and sorting by flow systems, 1231 Chromosome translocation

see also Translocation, genetic Gene dosage: Assignment of erythrocyte acid phosphatase locus to

chromosome 2, 4526 Human X-linked genes regionally mapped utilizing X-autosome

translocations and somatic cell hybrids, 2125 Chromosome, yeast

Cell cycle-dependent induction of mutations along yeast chromosome, 1179

Cichlid fish Trophic radiation through polymorphism in cichlid fishes, 4669

Ciliate, hypotrichous Inverted repetitious sequences in the macronuclear DNA of hypotrichous

ciliates, 678 Cinnamic acid, trans-4-hydroxy-

Stereochemistry of decarboxylation of trans-4-hydroxycinnamic acid by Aerobacter, 1681

Circadian activity Daily periodicity in the activity of a slide used to perform immunologic

reactions at a liquid-solid interface, 2462 Circadian pacemaker


Circadian rhythm Beta-adrenergic stimulation of pineal N-acetyltransferase: Adenosine

3':5'-cyclic monophosphate stimulates both RNA and protein synthesis, 2107

Circadian rhythm of neuron R15 of Aplysia californica:I'n vivo photoentrainment, 2408

Circadian rhythm of tyrosine hydroxylase induction by short-term cold stress: Modulatory action of glucocorticoids in newborn and adult rats, 1415


Ontogenesis of biological clock for serotonin:acetyl coenzyme A N-acetyltransferase in pineal gland of rat, 2814

Circular dichroism see Magnetic circular dichroism

Cirrhosis Sequential production of fatty liver, hepatitis, and cirrhosis in

sub-human primates fed ethanol with adequate diets, 437 Citrate (pro-3S)-lyase (EC 4.1.3.6)

Isolation of subunits of citrate lyase and characterization of function in enzyme complex, 3458

Citrate (si)-synthase (EC 4.1.3.7) Inhibition of citrate synthase by oleoyl-CoA: Regulatory phenomenon,

4729



14 Subject Index

Reversible, coenzyme-A-mediated inactivation of biosynthetic condensing enzymes in yeast: Regulatory mechanism, 1802

Citrobacter Sulfonamide resistance mechanism in Escherichia coli: R plasmids can

determine sulfonamide-resistant dihydropteroate synthases, 2621 Citryl-S-acyl carrier protein

Isolation of subunits of citrate lyase and characterization of function in enzyme complex, 3458

City size Distributions associated with Bose-Einstein statistics, 1654

Clam see Tindaria callistiformis

Classified theory, non-abelian Some fundamental groups in arithmetic of algebraic curves over finite

fields, 3281 Clostridium pasteurianum

Iron-sulfur cluster in hydrogenase from Clostridium pasteurianum W5, 4795

Clupeine Three-dimensional structure of herring sperm protamine Y-I with aid of

dark field electron microscopy, 4953 Cluster function

On some modified spherical models, 4723 Coastline

Stochastic models for Earth's relief, shape and fractal dimension of coastlines, and number-area rule for islands, 3825

Cobalamin Genetic complementation in heterokaryons of human fibroblasts

defective in cobalamin metabolism, 3181 Intracellular cobalamin-binding protein absent in cultured fibroblasts

from patients with defective synthesis of 5'-deoxyadenosylcobalamin and methylcobalamin, 4617

Methylmalonicacidemia: Biochemical heterogeneity in defects of 5'-deoxyadenosylcobalamin synthesis, 2799

Sulfhydryl dependence in primary explant hematopoietic cells: Inhibition of growth in vitro with vitamin B12 compounds, 73

Cobalt 13C nuclear magnetic resonance studies on mechanism of action of

carbonic anhydrase, 454 Cobalt(III), probe of metal binding sites of Escherichia coli alkaline

phosphatase, 394 Cobalt induction of hepatic heme oxygenase: Evidence that cytochrome

P-450 is not essential for this enzyme activity (correction), 772 Cochlea, cat

Receptor synapses without synaptic ribbons in cat cochlea, 3599 Coding, temporal, in nervous system

Impulse conduction along central axons, 5156 Coelenterate

Chemical nature of bioluminescence systems in coelenterates, 1546 Renilla-type luciferin extracted from calcium-activated photoproteins

aequorin, mnemiopsin, and berovin, 2530 Coelomomyces psorophorae

Life history of Coelomomyces psorophorae, 693 Coenzyme A

Coenzyme A requirement of malaria parasites: Coenzyme A precursors affect extracellular development in vitro of Plasmodium lophurae, 1834

Coenzyme A requirement of malaria parasites: Enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae, 2456


Coenzyme A, oleoyl- Inhibition of citrate synthase by oleoyl-CoA: Regulatory phenomenon,

4729 Coenzyme synthesis

Intracellular cobalamin-binding protein absent in cultured fibroblasts from patients with defective synthesis of 5'-deoxyadenosylcobalamin and methylcobalamin, 4617

Colcemide Effects of cytochalasin B and colcemide on myogenic cultures, 513

Colchicine Antibody against tubulin: Specific visualization of cytoplasmic

microtubules in tissue culture cells, 459 Colchicine affects kinetics of concanavalin A-mediated agglutination of

hepatoma cells and plasma membranes from liver and hepatoma cells, 498



Cold stress Circadian rhythm of tyrosine hydroxylase induction by short-term cold

stress: Modulatory action of glucocorticoids in newborn and adult rats, 1415

Colicin E3 Binding of ribosomal protein S1 of Escherichia coli to the 3' end of 16S

rRNA, 2940 Colicin K

Viability of Escherichia coli treated with colicin K, 4631 Coliphage

see Bacteriophage Collagen

Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta, 586




Interchain disulfide bonds in procollagen are located in large nontriple-helical COOH-terminal domain, 3009

Myogenesis of avian striated muscle in vitro: Role of collagen in myofiber formation, 2729

Patients with Ehlers-Danlos syndrome type IV lack type III collagen, 1314

Procollagen: Biological scission of amino and carboxyl extension peptides, 4905

Colagenase (EC 3.4.24.3) Interchain disulfide bonds in procollagen are located in large

nontriple-helical COOH-terminal domain, 3009 Colony hybridization

Colony hybridization: Method for isolation of cloned DNAs that contain a specific gene, 3961

Colony-stimulating factor Growth of mouse megakaryocyte colonies in vitro, 1744

Community structure Allelopathy and spatial competition among coral reef invertebrates, 5160

Compact group Bruhat decomposition for the loop space of compact group: New

approach to results of Bott, 4716 Compartmentalization, sub-cellular

Differential sub-cellular compartmentalization of thyrotropin releasing hormone (TRH) and gonadotropin releasing hormone (LRH) in hypothalamic tissue, 3153

Compensation rule Rate processes and compensation rule, 999

Competing risks Nonidentifiability aspect of problem of competing risks, 20

Competition, spatial Allelopathy and spatial competition among coral reef invertebrates, 5160

Competitive exclusion Topological theorem for nonlinear dynamics in chemical and ecological

networks, 2856 Complement

Immunochemical characterization of murine H-2 controlled Ss (serum substance) protein through identification of its human homologue as fourth component of complement, 4536

Mechanism of cytolysis by complement: Insertion of C5b and C7 subunits of C5b,6,7 complex into phospholipid bilayers of erythrocyte membranes, 5076

Neoantigens of membrane attack complex of human complement, 1687 New complement function: Solubilization of antigen-antibody

aggregates, 418 Third component of complement (C3): Structural properties in relation

to functions, 1989 Complementation, genetic

Genetic complementation in heterokaryons of human fibroblasts defective in cobalamin metabolism, 3181

Molecular basis of /-galactosidase a-complementation, 1254 Mutant hamster cells exhibiting pleiotropic effect on carbohydrate

metabolism, 469 Complement-derived chemotactic factor

Unique complement-derived chemotactic factor for tumor cells, 4128 Complement fixation

Structure and function of immunoglobulin domains: Studies with beta2-microglobulin on role of intrachain disulfide bond, 548

Complement-mediated immune attack Antigen mobility in membranes and complement-mediated immune

attack, 2483 Complement pathway, alternative

Properdin: Initiation of alternative complement pathway, 3220 Complexifications of real manifolds

Complexifications of real manifolds, 4210 Composite statistical hypothesis

Power of optimal asymptotic tests of composite statistical hypotheses, 577

Computer graphics Hemoglobin interaction in sickle cell fibers: Theoretical approaches to

molecular contacts, 1330 Computer modeling

Method for predicting RNA secondary structure, 2017 Computer simulation

Aggregated multienzyme system influences transient time: Kinetic evidence for compartmentation by aromatic-amino-acid-synthesizing complex of Neurospora crassa, 4218

Computer simulation of toroidal equilibrium and stability of a plasma in three dimensions, 926

Feedback dynamics analysis of secondary successional transients in ecosystems, 2733

Interlocus variation of genetic distance and neutral mutation theory, 2758

Concanavalin A see also Lectin Colchicine affects kinetics of concanavalin A-mediated agglutination of



Distribution of membrane particles and gap junctions in normal and transformed 3T3 cells studied in situ, in suspension, and treated with concanavalin A, 572

Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by concanavalin A, 4409

Increased cellular levels of spermidine or spermine are required for





Induction of endogenous murine C-type virus in spleen cell cultures treated with mitogens and 5-bromo-2'-deoxyuridine, 535

Leukocyte migration inhibitory factor (LMIF) induced by concanavalin A: Standardized microassay for production in vitro, 3197


Modulation of lymphocyte receptor mobility by locally bound concanavalin A, 1579

Periodate and concanavalin A induce blast transformation of rat lymphocytes by indirect mechanism, 3590

Concentration gradient, spatial Signal input for chemotactic response in cellular slime mold

Dictyostelium discoideum, 4991 Conformational analysis

Empirical intermolecular and conformational potential energy functions: II. Crystal packing, rotational barriers, and conformational analysis, 854

Conformational change see also Protein conformation Activation of antibody Fc function by antigen-induced conformational

changes, 5111 Antigen-induced conformational changes in antibodies and their Fab

fragments studied by circular polarization of fluorescence, 2775 Catalysis by acetylcholinesterase: Evidence that the rate-limiting step for


Kinetics of opiate receptor inactivation by sulfhydryl reagents: Evidence for conformational change in presence of sodium ions, 2404



Conformational energy New approach to empirical intermolecular and conformational potential


Conformational potential Sidechain torsional potentials and motion of amino acids in proteins:

Bovine pancreatic trypsin inhibitor, 2002 Conformational state


Congruence relation Some fundamental groups in arithmetic of algebraic curves over finite

fields, 3281 Congruence subgroup

Homology of congruence subgroups and K3(Z), 651 Conjugation, bacterial

Mating signal and DNA penetration deficiency in conjugation between male Escherichia coli and minicells, 3721

Connective tissue Patients with Ehlers-Danlos syndrome type IV lack type III collagen,

1314 Connectivities Ri

Connectivities1Ri of Frechet spaces in variational topology, 2069 Contact inhibition

Contact inhibition of phagocytosis in epithelial sheets: Alterations of cell surface properties induced by cell-cell contacts, 719

Differences in membrane fluidity and structure in contact-inhibited and transformed cells (correction), 1217

Contact, intercellular Establishment of tight junctions between epithelial cells, 2711

Containment Summary statement of Asilomar conference on recombinant DNA

molecules, 1981 Contracting substance, rabbit aorta

Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides, 2994

Control see also Metabolic control; Regulation

Control, autogenous A Repressor turns off transcription of its own gene, 4785

Control, stringent Effects of guanosine tetraphosphate on cell-free synthesis of Escherichia

coli ribosomal RNA and other gene products, 2881 Control, transmembrane


Convex program Lagrange multiplier method for convex programs, 1778

Convolution Inequalities in Fourier analysis on Rn, 638

Convolution operator Spectra of convolution operators on Lp spaces, 3285

Cooperativity, negative Nonsaturable, homogeneous transport system in Bacillus subtilis:

Genetic, kinetic, and affinity labeling studies, 814 Coordination complex

Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase A: Monitor of multiple conformational states in solution, 4356

Copepod see also Cyclops vernalis

Copepod, calanoid Chemoreceptors and feeding in calanoid copepods (Arthropoda:

Crustacea), 4185

Subject Index 15

Coral reef Allelopathy and spatial competition among coral reef invertebrates, 5160

Cordycepin Cellular protein synthesis required in reversal of


Corn see Avena sativa; Hordeum vulgare; Triticum aestivum; Zea mays

Corneal epithelium Human epidermal growth factor: Isolation and chemical and biological

properties, 1317 Coronary vasodilation

Mechanism and modification of bradykinin-induced coronary vasodilation, 2060

Corpus callosum Impulse conduction along central axons, 5156

Corpus striatum Dopamine receptor binding in corpus striatum of mammalian brain, 4655

Corrections Active transport of calcium in inverted vesicles of Escherichia coli, 2833 Apparent dependence of interactions between cytochrome b5 and

cytochrome b5 reductase upon translational diffusion in dimyristoyl lecithin liposomes, 4679

Authors' statement on the isolation of mRNA coding for immunoglobulin heavy chain, 4679

Cell-division factors from Vinca rosea L. crown gall tumor tissue, 3260 Chemical nature of transfer factor (authors' statement), 409 Cobalt induction of hepatic heme oxygenase: Evidence that cytochrome

P-450 is not essential for this enzyme activity, 772 Cooperative activation of action potential Na+ ionophore by neurotoxins,

3260 Differences in membrane fluidity and structure in contact-inhibited and

transformed cells, 1217 Electrostatic basis of Mg++ inhibition of transmitter release, 409 Enhancement of soybean RNA polymerase I by auxin, 2468 Fetal mouse hearts: Model for studying ischemia, 4679 Genes, restriction sites, and DNA sequences surrounding 6S RNA

template of bacteriophage X, 3753, Immunoreactive somatostatin is present in discrete cells of endocrine

pancreas, 2833 Methylated nucleotides block 5'-terminus of vaccinia virus messenger

RNA, 1645 Nerve growth factor induces volume increase and enhances tyrosine

hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats, 3261


On equimultiple subvarieties of algebroid hypersurfaces, 3260 Origin of hemopoietic stem cells in embryonic bursa of Fabricius and

bone marrow studied through interspecific chimeras, 5164 Reovirus messenger RNA contains a methylated, blocked 5'-terminal

structure: m7G(5')ppp(5')GmpCp-, 2468 Transfer factor: Subcellular component that transmits information for

specific immune responses (authors' statement), 409 Xeroderma pigmentosum cells contain low levels of photoreactivating

enzyme, 2468 Cortex, somatosensory

Mouse SmI cortex: Qualitative and quantitative classification of Golgi-impregnated barrel neurons, 2165

Cortex, visual Development of receptive fields in rabbit visual cortex: Changes in time

course due to delayed eye-opening, 1543 Cortical organization

Mouse SmI cortex: Qualitative and quantitative classification of .Golgi-impregnated barrel neurons, 2165

Corticosteroid Inhibition of replication of normal adrenocortical cells in culture by

adrenocorticotropin, 113 Corticosterone


Corticotropin Inhibition of replication of normal adrenocortical cells in culture by

adrenocorticotropin, 113 Molecular weights of adrenocorticotropic hormone in extracts of anterior

and intermediate-posterior lobes of mouse pituitary, 3565 Cosmochemistry

Solar abundance of platinum, 4193 Cosmology



Progress and prospects in high energy astrophysics, 4685 Cotton

see Gossypium barbadense p-Coumaric acid


Courant penalty function Lagrange multiplier method for convex programs, 1778

Crab see Callinectes sapidus

Cranial capacity Evolution of human longevity and genetic complexity governing aging

rate, 4664 Crash, airplane

Reactions of migrating birds to lights and aircraft, 1994



16 Subject Index

Cricket see Acheta domesticus

Critical variety of a projection On equimultiple subvarieties of algebroid hypersurfaces, 1425 On equimultiple subvarieties of algebroid hypersurfaces (correction),

3260 Crossing-over

Electron microscopy of meiosis in Drosophila melanogaster females: Recombination nodule-a recombination-associated structure at pachytene? 3186

Presynaptic events in meiocytes of Lilium longiflorum and relation to crossing-over: A preselection hypothesis, 961

Crown gall tumpr tissue Cell-division factors from Vinca rosea L. crown gall tumor tissue, 1883 Cell-division factors from Vinca rosea L. crown gall tumor tissue

(correction), 3260 Crustacea

see also Artemia; Callinectes; Cyclops Chemoreceptors and feeding in calanoid copepods (Arthropoda:

Crustacea), 4185 Crypthecodinium (Gyrodinium) cohnii

Genetic analysis in dinoflagellate Crypthecodinium (Gyrodinium) cohnii: Unusual meiosis, 4546

Crystal see also Liquid crystal

Crystal packing Empirical intermolecular and conformational potential energy functions:

II. Crystal packing, rotational barriers, and conformational analysis, 854

Crystal structure Phase problem in crystallography, 1699

Crystallography, phase problem Phase problem in crystallography, 1699

C-type particle A-type and C-type particles in cells infected by Rous sarcoma virus, 3706

C-type virus C-type virus particles in placenta of normal healthy Sprague-Dawley rats,

3240 Electron microscopic study of virus particles in rhesus monkey placenta,

118 Evolution of type C viral genes: Preservation of ancestral murine type C

viral sequences in pig cellular DNA, 4090 Genetic control of endogenous C-type virus production in pancreatic

acinar cells of C57BL/He and C57BL/6J mice, 1892 Growth and differentiation in culture of leukemic leukocytes from

patient with acute myelogenous leukemia and re-identification of type-C virus, 4137



Isolation from Asian mouse Mus caroli of endogenous type C virus related to infectious primate type C viruses, 2315

Murine C-type virus inducing locus Akv-1 is viral genetic material, 906 RNA-directed DNA polymerase from human leukemic blood cells and

from primate type-C virus-producing cells: High- and low-molecular-weight forms with variant biochemical and immunological properties, 1194

Viral-related information in oncornavirus-like particles isolated from cultures of marrow cells from leukemic patients in relapse and remission, 623

Virus-specific neutralization by soluble non-immunoglobulin factor found naturally in normal mouse sera, 5071

Cucumber see Cucumis sativus

Cucumis sativus Satellite-rich DNA in cucumber: Hormonal enhancement of synthesis

and subcellular identification, 2260 Culiseta inornata

Life history of Coelomomyces psorophorae, 693 ,3-Cyanoalanine synthase (EC 4.4.1.9)

Beta-cyanoalanine synthase: Purification and characterization, 1617 Cyanophyte

see Paleopleurocapsa wopfnerii Cycle completion

Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams, 1291

Cyclic AMP see Adenosine 3':5'-cyclic monophosphate

Cyclic GMP see Guanosine 3':5'-cyclic monophosphate

Cyclobutane Fall-off from extrapolated values of all chemical reactions at very high

temperatures, 1717 Cycloheximide

Cellular protein synthesis required in reversal of ethidium-bromide-induced inhibition of cell transformation by murine sarcoma virus, 4337


Nature of increase in renal ornithine decarboxylase activity after cycloheximide administration in rat, 2279

Cyclo-oxygenase deficiency Physiological role of an endoperoxide in human platelets: Hemostatic

defect due to platelet cyclo-oxygenase deficiency, 1446 Cyclophosphamide

Mutagenicity of chloroacetaldehyde, a possible metabolic product of


1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide, 3190

Cyclopropane Fall-off from extrapolated values of all chemical reactions at very high

temperatures, 1717 Cyclops vernalis

Life history of Coelomomyces psorophorae, 693 Cylindrical tissue

Analogue solution for electrical capacity of membrane covered square cylinders in square array at high concentration, 4936

Cysteine hydrochloride Nuclear coupling of 33S and nature of free radicals in irradiated crystals

of cysteine hydrochloride and N-acetyl methionine, 3486 L-Cystine

Utilization of L-cystine by y-glutamyl transpeptidase-'Y-glutamyl cyclotransferase pathway, 1985

Cytidine diphosphate diglyceride Isolation of Escherichia coli mutants defective in enzymes of membrane

lipid synthesis, 2274 Cytochalasin B

Biochemical lesions used for selection of human cells with hybrid cytoplasms, 1812

Cell cycle studies of mononucleate and cytochalasin-B-induced binucleate fibroblasts, 869

Effects of cytochalasin B and colcemide on myogenic cultures, 513 RNAs of simian virus 40 in productively infected monkey cells: Kinetics

of formation and decay in enucleate cells, 2587 Cytochrome b5

Apparent dependence of interactions between cytochrome b5 and cytochrome b5 reductase upon translational diffusion in dimyristoyl lecithin liposomes, 2658

Apparent dependence of interactions between cytochrome b5 and cytochrome b5 reductase upon translational diffusion in dimyristoyl lecithin liposomes (correction), 4679

Cytochrome b5 reductase (EC 1.6.2.2) Apparent dependence of interactions between cytochrome b5 and



Cytochrome a oxidase subunits (EC 1.9.3.1) Biosynthesis of polypeptides of cytochrome c oxidase by isolated

mitochondria, 172 Cytochrome oxidase

Cytoplasmic mutants of Saccharomyces cerevisiae with specific lesions in cytochrome oxidase, 2054

Functional intermediates in reaction of cytochrome oxidase with oxygen, 1635

Resonance Raman effect in A-oxo-bis[iron(III)tetraphenylporphyrin], 4419

Cytochrome P-450 Apocytochrome P-450: Reconstitution of functional cytochrome with

hemin in vitro, 400 Cobalt induction of hepatic heme oxygenase: Evidence that cytochrome

P-450 is not essential for this enzyme activity (correction), 772 Position-specific oxygenation of benzo[a]pyrene by different forms of

purified cytochrome P-450 from rabbit liver, 3917 Cytokine

Biologic and antigenic similarity of virus-induced migration inhibition factor to conventional, lymphocyte-derived migration inhibition factor, 1641

Cytokinesis Changing patterns of actin localization during cell division, 1913

Cytokinin Cell-division factors from Vinca rosea L. crown gall tumor tissue, 1883 Cell-division factors from Vinca rosea L. crown gall tumor tissue

(correction), 3260 Two responses to auxin separated by cytokinin inhibition, 1822

Cytokinin antagonist Anticytokinin activity of substituted pyrrolo[2,3-d]pyrimidines, 3508

Cytolysis see also Lysis Mechanism of cytolysis by complement: Insertion of C5b and C7

subunits of C5b,6,7 complex into phospholipid bilayers of erythrocyte membranes, 5076

Cytotoxicity see also Lysis Cytotoxic effector cells specific for B cell lines transformed by

Epstein-Barr virus are present in patients with infectious mononucleosis, 1622

Different responses of lymphoid cells from tumor-bearing as compared to tumor-immunized mice when sensitized to tumor specific antigens in vitro, 5086

Immunosurgery of mouse blastocyst, 5099 Lymphocyte cytotoxicity augmented by antibody to herpesvirus saimiri

associated antigens, 1671 Lymphocyte cytotoxicity to autologous liver cells in chronic active

hepatitis, 1301 Cytotoxin

Mutagenic and cytotoxic activity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols, 3176

Dacus dorsalis Oriental fruit fly, Dacus dorsalis, attracted to methyl eugenol and

related olfactory stimulants, 2501




Dane particle Genome of hepatitis B virus: Restriction enzyme cleavage and structure

of DNA extracted from Dane particles, 4597 Decarboxylation, enzymatic


Decay of l to k Pion spectrum in decay of V'(3.7) to t(3.1), 4216

Dedekind's x-function Dedekind's a-function and cohomology of infinite dimensional Lie

algebras, 2493 Defense mechanism, plant

Species richness of parasitic fungi of British trees, 2116 Deletion, genetic

Biochemical procedure for production of small deletions in simian virus 40 DNA, 1392

Denaturation mapping Visualization of novel junction in bacteriophage X DNA, 3024

Dendrostomum see Themiste

Dense media Magnetic circular dichroism of molecules in dense media: Relation

between magnetic circular dichroism and Hammett's constants, 452 Deoxyribonuclease II

Structure of transcriptionally active chromatin, 4404 Deoxyribonuclease II (EC 3.1.4.6)


Deoxyribonucleic acid, bacterial, exogenous Integration of exogenous bacterial DNA into plant DNA, 2748

Deoxyribonucleic acid binding protein Competent Bacillus subtilis cultures synthesize denatured DNA binding

activity, 323 Low-molecular-weight DNA-binding protein, H1 factor, affects in vitro

transcription of lactose operon in Escherichia coli, 333 Model for regulation of Escherichia coli DNA repair functions, 2330 Novel, low-molecular-weight DNA-binding protein from Escherichia

coli, 3428 Deoxyribonucleic acid, cell surface

Cell-surface-associated nucleic acid in tumorigenic cells made visible with platinum-pyrimidine complexes by electron microscopy, 928

Deoxyribonucleic acid chain growth Retarded rate of DNA chain growth in Bloom's syndrome, 758

Deoxyribonucleic acid, chloroplast Satellite-rich DNA in cucumber: Hormonal enhancement of synthesis

and subcellular identification, 2260 Deoxyribonucleic acid, circular

Epstein-Barr virus genomes with properties of circular DNA molecules in caririer cells, 1477

Partially purified simian virus 40 T antigen interacts with circular viral DNA molecules, 1960

Deoxyribonucleic acid cloning Cloning, isolation, and characterization of replication regions of complex

plasmid genomes, 2242 Colony hybridization: Method for isolation of cloned DNAs that contain

a specific gene, 3961 Deoxyribonucleic acid, cohesive termini of

Isolation of bacteriophage lambda A-gene protein, 581 Deoxyribonucleic acid, complementary

Relative numbers of human globin genes assayed with purified a and f3 complementary human DNA, 1550

Deoxyribonucleic acid concatemer Proposal concerning mechanism of evolution of the genome of

Escherichia coli, 1354 Deoxyribonucleic acid condensate

DNA condensates induced by poly(ethylene oxide) and polylysine, 4288 Deoxyribonucleic acid cytophotometry

Chromosome measurement and sorting by flow systems, 1231 Deoxyribonucleic acid, cytoplasmic-membrane-associated


Deoxyribonucleic acid, damaged Mechanism of bacteriophage lambda induction: Acquisition of binding

sites for lambda repressor by host DNA, 1973 Deoxyribonucleic acid double-strand break

Enzymatic induction of DNA double-strand breaks in y-irradiated Escherichia coli K-12, 4265

Deoxyribonucleic acid, drug-resistance factor Transformation of Pseudomonas putida and Escherichia coli with

plasmid-linked drug-resistance factor DNA, 3647 Deoxyribonucleic acid fragment

Herpes simplex virus DNA: Four populations of molecules that differ in relative orientations of long and short components, 4243


Deoxyribonucleic acid helix Conformational fluctuations of DNA helix, 4275 Folding of DNA double helix in chromatin-like structures from simian

virus 40, 1843 Deoxyribonucleic acid, heteroduplex

Influence of insertions on packaging of host sequences covalently linked to bacteriophage Mu DNA, 4399

Mismatch repair in heteroduplex DNA, 2202 Deoxyribonucleic acid-histone interaction

Preferential and cooperative binding of histone I to chromosomal mammalian DNA, 733

Deoxyribonucleic acid, integration Integration of exogenous bacterial DNA into plant DNA, 2748

Subject Index 17

Deoxyribonucleic acid, interaction with alkali Alkali ion-DNA interaction as reflected in nuclear relaxation rates of

23Na and 87Rb, 245 Deoxyribonucleic acid, intercalation

DNA polyintercalating drugs: DNA binding of diacridine derivatives, 2915

X-ray crystallographic visualization of drug-nucleic acid intercalative binding: Structure of an ethidium-dinucleoside monophosphate crystalline complex, ethidium: 5-'iodouridylyl(3'-5')adenosine, 628

X-ray fiber diffraction evidence for neighbor exclusion binding of platinum metallointercalation reagent to DNA, 4825

Deoxyribonucleic acid ligase see Polynucleotide synthetase

Deoxyribonucleic acid ligase gene In vitro construction of bacteriophage X carrying segments of


Deoxyribonucleic acid, macronuclear Inverted repetitious sequences in the macronuclear DNA of hypotrichous

ciliates, 678 Deoxyribonucleic acid, mammalian

Analysis of DNA of isolated chromatin subunits, 3978 Preferential and cooperative binding of histone I to chromosomal

mammalian DNA, 733 Deoxyribonucleic acid mapping

Human papillomavirus DNA: Physical map, 4810 T antigen binds to simian virus 40 DNA at the origin of replication, 1605

Deoxyribonucleic acid-membrane attachment Effect of growth conditions on DNA-membrane attachment in

Escherichia coli, 2446 Deoxyribonucleic acid, mitochondrial

Complementation in cytoplasmic petite mutants of yeast to form respiratory competent cells, 372

Restriction endonuclease analysis of mitochondrial DNA from grande and genetically characterized cytoplasmic petite clones of Saccharomyces cerevisiae, 3868

Satellite-rich DNA in cucumber: Hormonal enhancement of synthesis and subcellular identification, 2260

Specific cleavage analysis of mammalian mitochondrial DNA, 4496 Deoxyribonucleic acid molecule, recombinant

Biochemical construction and selection of hybrid plasmids containing specific segments of Escherichia coli genome, 4361


In vitro construction of bacteriophage X carrying segments of Escherichia coli chromosome: Selection of hybrids containing DNA ligase gene, 3416

Recombinant DNA molecules of bacteriophage kX174, 235 Summary statement of Asilomar conference on recombinant DNA

molecules, 1981 Deoxyribonucleic acid, nonsupercoiled closed circular

Action of nicking-closing enzyme on supercoiled and nonsupercoiled closed circular DNA: Formation of Boltzmann distribution of topological isomers, 4280

Deoxyribonucleic acid, novel junction Visualization of novel junction in bacteriophage X DNA, 3024

Deoxyribonucleic acid nucleotide sequence Genes, restriction sites, and DNA sequences surrounding 6S RNA

template of bacteriophage X, 1817 Genes, restriction sites, and DNA sequences surrounding 6S RNA

template of bacteriophage X (correction), 3753 Human RNA transcripts among heterogeneous nuclear RNA from

man-mouse somatic cell hybrids, 1868 Inverted repetitious sequences in the macronuclear DNA of hypotrichous

ciliates, 678 Nucleotide sequence of rightward operator of phage X, 1184 Nucleotide sequence of RNA polymerase binding site from DNA of

bacteriophage fd, 737 Nucleotide sequence of RNA polymerase binding site from DNA of

bacteriophage fd (correction), 2468 Deoxyribonucleic acid nucleotidyltransferase a

RNA-primed DNA synthesis: Specific catalysis by HeLa cell DNA polymerase a, 503

Deoxyribonucleic acid nucleotidyltransferase (EC 2.7.7.7) De novo synthesis of polymer of deoxyadenylate and deoxythymidylate

by calf thymus DNA polymerase a, 3944 DNA polymerase stimulated by factors isolated from Novikoff hepatoma,

1171 DNA synthesis involving a complexed form of DNA polymerase I in

extracts of Escherichia coli, 2099 Genome of hepatitis B virus: Restriction enzyme cleavage and structure

of DNA extracted from Dane particles, 4597 Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid dependent

Affinity chromatography of viral DNA polymerases on pyran-Sepharose, 1142

Growth and differentiation in culture of leukemic leukocytes from patient with acute myelogenous leukemia and re-identification of type-C virus, 4137

Inhibition of oncornavirus functions by 2'-azido polynucleotides, 284 In vitro synthesis of full-length DNA transcripts of Rous sarcoma virus

RNA by viral DNA polymerase, 4895 Purification of RNA-instructed DNA polymerase from human leukemic

spleens, 4133 Region of immunoglobulin light-chain mRNA transcribed into

complementary DNA by RNA-dependent DNA polymerase of avian myeloblastosis virus, 2511

RNA-directed DNA polymerase from human leukemic blood cells and from primate type-C virus-producing cells: High- and



18 Subject Index

low-molecular-weight forms with variant biochemical and immunological properties, 1194

RNA-directed DNA synthesis by DNA polymerase of Rous sarcoma virus: Structural and functional identification of 4S primer RNA in uninfected cells, 859

Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid dependent (EC 2.7.7.7)

Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase), 2535


Deoxyribonucleic acid packaging Isolation of bacteriophage lambda A-gene protein, 581 Mutants of T7 bacteriophage inhibited by lambda prophage, 3642

Deoxyribonucleic acid, plant Integration of exogenous bacterial DNA into plant DNA, 2748

Deoxyribonucleic acid, plasmid Bidirectional replication of plasmid R6K DNA in Escherichia coli:

Correspondence between origin of replication and position of single-strand break in relaxed complex, 2905

Plasmid interactions in Staphylococcus aureus: Nonadditivity of compatible plasmid DNA pools, 5031

Specificity of substrate recognition by EcoRI restriction endonuclease, 3310

Transformation of Pseudomonas putida and Escherichia coli with plasmid-linked drug-resistance factor DNA, 3647


Deoxyribonucleic acid polymerase see Deoxyribonucleic acid nucleotidyltransferase

Deoxyribonucleic acid, proviral Recovery of infectious proviral DNA from mammalian cells infected with

respiratory syncytial virus, 3230 Deoxyribonucleic acid-relaxing enzyme

Purified DNA-relaxing enzyme from human tissue culture cells, 2550 Deoxyribonucleic acid renaturation

Nucleic acid reassociation kinetics: Reactivity of single-stranded tails in DNA.DNA renaturation, 4805

Deoxyribonucleic acid repair see also Excision repair DNA strand breaks measured within 100 milliseconds of irradiation of

Escherichia coli by 4 MeV electrons, 167 Endonucleolytic incision of x-irradiated deoxyribonucleic acid by

extracts of Escherichia coli, 1997 Genetic evidence for an additional function of phage T4 gene 32 protein:

Interaction with ligase, 1226 Genetic heterogeneity in xeroderma pigmentosum: Complementation

groups and their relationship to DNA repair rates, 59 Inducible error-prone repair in Escherichia coli, 2753 Induction by alkylating agents of sister chromatid exchanges and

chromatid breaks in Fanconi's anemia, 4066 Induction of error-prone repair as consequence of DNA ligase deficiency

in Escherichia coli, 4645 Mismatch repair in heteroduplex DNA, 2202 Model for regulation of Escherichia coli DNA repair functions, 2330 Mutations simultaneously affecting endonuclease II and exonuclease III

in Escherichia coli, 688 Restoration of ultraviolet-induced unscheduled DNA synthesis of

xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus), 4071

Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme, 103

Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme (correction), 2468

Deoxyribonucleic acid replication Association of OX174 DNA-dependent ATPase activity with Escherichia

coli protein, replication factor Y, required for in vitro synthesis of 5X174 DNA, 3342

Cell cycle-dependent induction of mutations along yeast chromosome, 1179

Cloning, isolation, and characterization of replication regions of complex plasmid genomes, 2242

DNA replication in vitro starting with an intact kX174 phage, 3863 Effect of growth conditions on DNA-membrane attachment in

Escherichia coli, 2446 Genetic evidence for an additional function of phage T4 gene 32 protein:

Interaction with ligase, 1226 Interaction of Escherichia coli dnaB and dnaC(D) gene products in

vitro, 921 Model for compartmentation of de novo and salvage thymidine

nucleotide pools in mammalian cells, 3333 Novel mutants of Escherichia coli that accumulate very small DNA

replicative intermediates, 2150 Presynaptic events in meiocytes of Lilium longiflorum and relation to

crossing-over: A preselection hypothesis, 961 Purified DNA-relaxing enzyme from human tissue culture cells, 2550 Reconstruction of bacteriophage T4 DNA replication apparatus from

purified components: Rolling circle replication following de novo chain initiation on single-stranded circular DNA template, 4800

Repetitive DNA replication of incomplete genomes of phage T4 petite particles, 1734

Replication of colicin E1 plasmid DNA added to cell extracts, 1050 4X174 DNA-dependent DNA synthesis in vitro: Requirement for P1 ban

protein in dnaB mutant extracts of Escherichia coli, 3907 Deoxyribonucleic acid, replicative intermediates

Replicative intermediates of colicin E1 plasmid DNA in minicells, 829


Deoxyribonucleic acid, satellite Localization of cytoplasmic-membrane-associated DNA in human

chromosomes, 5004 Satellite-rich DNA in cucumber: Hormonal enhancement of synthesis

and subcellular identification, 2260 Deoxyribonucleic acid sequence

see Deoxyribonucleic acid nucleotide sequence Deoxyribonucleic acid, single-stranded

Mapping mutational alterations in DNA with S1 nuclease: Location of deletions and temperature-sensitive mutations in simian virus 40, 989

Site-specific cleavage of single-stranded DNA by Hemophilus restriction endonuclease, 2555

Uptake of homologous single-stranded fragments by superhelical DNA: Possible mechanism for initiation of genetic recombination, 2394

Deoxyribonucleic acid, single-strand scission Single-strand scissions of chromosomal DNA during commitment to

recombination at meiosis, 1887 Deoxyribonucleic acid structure

Chromatin architecture: Investigation of subunit of chromatin by dark field electron microscopy, 2691


Deoxyribonucleic acid, supercoiled, closed circular Action of nicking-closing enzyme on supercoiled and nonsupercoiled

closed circular DNA: Formation of Boltzmann distribution of topological isomers, 4280

Deoxyribonucleic acid, superhelical Determination of number of superhelical turns in simian virus 40 DNA

by gel electrophoresis, 4876 Interaction of fl histone with superhelical DNA, 2597 Purified DNA-relaxing enzyme from human tissue culture cells, 2550 Uptake of homologous single-stranded fragments by superhelical DNA:

Possible mechanism for initiation of genetic recombination, 2394 Deoxyribonucleic acid synthesis

Adenosine diphosphate ribosylation of Ca2+, Mg2+-dependent endonuclease, 289

Chromatin and DNA synthesis associated with nuclear membrane in germinating cotton, 3134

Cytoplasmic control of nuclear DNA synthesis during early development of Xenopus laevis: Cell-free assay, 2437

DNA polymerase stimulated by factors isolated from Novikoff hepatoma, 1171

DNA synthesis involving a complexed form of DNA polymerase I in extracts of Escherichia coli, 2099

Genome of hepatitis B virus: Restriction enzyme cleavage and structure of DNA extracted from Dane particles, 4597

Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A, 4042

Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2,,, 2724


R-factor replication in presence of chloramphenicol, 654 Ribonuclease-sensitive DNA-synthesizing complex in human sperm

heads and seminal fluid, 3295 RNA-directed DNA synthesis by DNA polymerase of Rous sarcoma

virus: Structural and functional identification of 4S primer RNA in uninfected cells, 859



Sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytes, 1950

Stimulus to DNA synthesis in cultures of chick embryo cells is nonspecific, 1676


Synthesis of DNA complementary to separated human alpha and beta globin messenger RNAs, 984

Transformation by polyoma virus alters expression of cell mutation affecting cycle traverse, 2540

Viral and cellular DNA synthesis in nuclei from human lymphocytes transformed by Epstein-Barr virus, 2413

Xeroderma pigmentosum cells with normal levels of excision repair have defect in DNA synthesis after UV-irradiation, 219

Deoxyribonucleic acid template Separation of lymphocyte chromatin into template-active fractions with

specificity for eukaryotic RNA polymerase II or prokaryotic RNA polymerase, 4830

Deoxyribonucleic acid terminal repetition, inverted Arrangement of sequences in the inverted terminal repetition of

adenovirus 18 DNA, 3039 Deoxyribonucleic acid transcription

see Transcription of deoxyribonucleic acid Deoxyribonucleic acid, unintegrated double-stranded

Murine leukemia virus: Detection of unintegrated double-stranded DNA forms of the provirus, 447

Deoxyribonucleic acid unwinding protein De novo synthesis of polymer of deoxyadenylate and deoxythymidylate

by calf thymus DNA polymerase a, 3944 Deoxyribonucleic acid, viral

Anatomy of herpes simplex virus DNA: Strain differences and heterogeneity in locations of restriction endonuclease cleavage sites, 1768





Determination of number of superhelical turns in simian virus 40 DNA by gel electrophoresis, 4876


Infectious viral DNA of murine leukemia virus, 4910 Integrative recombination of bacteriophage lambda DNA in vitro, 1072 Interaction of fl histone with superhelical DNA, 2597 Location of histones on simian virus 40 DNA, 2895 Purified DNA-relaxing enzyme from human tissue culture cells, 2550 Simian virus 40 DNA directs synthesis of authentic viral polypeptides in

linked transcription-translation cell-free system, 1922 Deoxyuridine, 5-bromo-


Correlated suppression by 5-bromodeoxyuridine of tumorigenicity and plasminogen activator in mouse melanoma cells, 47

Distribution and virogenic effects of 5-bromodeoxyuridine in synchronized rat embryo cells, 1829


Depolarization-secretion coupling Calcium role in depolarization-secretion coupling: Aequorin study in

squid giant synapse, 187 Derepression


Desensitization, pharmacological Regulation of binding properties of nicotinic receptor protein by

cholinergic ligands in membrane fragments from Torpedo marmorata, 3443

Detergent Inhibition of citrate synthase by oleoyl-CoA: Regulatory phenomenon,

4729 Physical characteristics of the gonadotropin receptor-hormone

complexes formed in vivo and in vitro, 1272 Determinants, inequality among

Inequality among determinants, 3277 Dkitoxification


Deuterium oxide isotope effect Catalysis by acetylcholinesterase: Evidence that the rate-limiting step for


Development see also Differentiation, cell Changes in relative levels of guanosine-3':5'-monophosphate-dependent




Epithelial cell death and cyclic AMP increase during palatal development, 874



Dexamethasone Effect of chemical inactivating agents on glucocorticoid receptor proteins

in mouse and hamster cells, 3060 Genetic control of endogenous C-type virus production in pancreatic

acinar cells of'C57BL/He and C57BL/6J mice, 1892 Diabetes

Diabetes mellitus: Changes in transport properties of isolated intestinal microvillous membranes, 2027

Synthesis of hemoglobin Aic in normal and diabetic mice: Potential model of basement membrane thickening, 3687

Diacridine derivative DNA polyintercalating drugs: DNA binding of diacridine derivatives,

2915 Diagnosis, prenatal

Expression of /-thalassemia gene in first trimester fetus, 3633 Dialysis

Significance of retention of ligand by protein, 2120 Diarrhea

Interaction of cholera toxin and membrane GM1 ganglioside of small intestine, 2520

1,2-Dichloroethane Mutagenicity of chloroacetaldehyde, a possible metabolic-product of


2,4-Dichlorophenoxyacetic acid Enhancement of soybean RNA polymerase I by auxin, 69 Enhancement of soybean RNA polymerase I by auxin (correction), 2468

Dictyostelium discoideum Cell surface species-specific high affinity receptors for discoidin:

Developmental regulation in Dictyostelium discoideum, 3541 Chemotactic signals induce cell differentiation in Dictyostelium

discoideum, 3163 Guanosine metabolism and regulation of fruiting body construction in

Dictyostelium discoideum, 4479 Ribonucleoprotein particles containing heterogeneous nuclear RNA in

cellular slime mold Dictyostelium discoideum, 301

Subject Index 19


Visualization of actin fibers associated with cell membrane in amoebae of Dictyostelium discoideum, 1758

Dictyostelium giganteum Sexuality in cellular slime mold Dictyostelium giganteum, 970

Dielectric constant Physical basis of charge pairing in mitochondria, 2058 Spectator-ion effect on passage of ions through membranes, 683

Dielectric properties of biological material Extraordinary dielectric properties of biological materials and action of

enzymes, 4211 Diet

see also Feeding; Food intake; Nutritional response Body weight and food intake at early estrus of rats on high-fat diet, 4172 Sequential production of fatty liver, hepatitis, and cirrhosis in

sub-human primates fed ethanol with adequate diets, 437 Dietary allowance

Further comments on ascorbic acid requirement, 4151 Differential cross section


Differentiation, cell see also Development

Differentiation, cell, microorganisms Cell surface species-specific high affinity receptors for discoidin:

Developmental regulation in Dictyostelium discoideum, 3541 Chemotactic signals induce cell differentiation in Dictyostelium

discoideum, 3163 Conditions controlling commitment of differentiation in Bacillus

megaterium, 4037 Cyclic nucleotide metabolism coupled to cytodifferentiation of

Blastocladiella emersonii, 442 Guanosine metabolism and regulation of fruiting body construction in

Dictyostelium discoideum, 4479 Regulation of development in Myxococcus xanthus: Effect of 3':5'-cyclic

AMP, ADP, and nutrition, 518 Differentiation, cell, mouse erythroleukemia

Differentiation in erythroleukemic cells and their somatic hybrids, 98 Erythroid differentiation induced by dimethylsulfoxide in cells infected

with Friend virus: Relationship to cell cycle, 28 Induction of endogenous and of spleen focus-forming viruses during

dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus, 1863


Purine metabolism in murine virus-induced erythroleukemic cells during differentiation in vitro, 1630

Differentiation, cell, other animal cells Aging and its relation to cell growth and differentiation in Drosophila


Cerebellar cell surface antigens of mouse brain, 4110 Cholinergic differentiation of presumptive adrenergic neuroblasts in

interspecific chimeras after heterotopic transplantations, 728 Differentiation of clonal lines of teratocarcinoma cells: Formation of

embryoid bodies in vitro, 1441 Differentiation of peripheral blood lymphocytes into cells bearing sheep

erythrocyte receptors in vitro by human thymic extract, 1175 Effect of oncogenic virus on muscle differentiation, 4051 Epithelial cell death and cyclic AMP increase during palatal

development, 874 Gene expression in mouse neuroblastoma cells: Properties of the genome,

3119 Inhibition of replication of normal adrenocortical cells in culture by

adrenocorticotropin, 113 Origin of hemopoietic stem cells in embryonic bursa of Fabricius and


bone marrow studied through interspecific chimeras (correction), 5164 Poly(ADP-Rib) synthesis, intracellular NAD levels, and muscle or

cartilage differentiation from mesodermal cells of embryonic chick limb, 1852

Polypeptide with lymphocyte-differentiating properties and probably represented universally in living cells, 11

Synthesis of acetylcholine receptor during differentiation of cultured embryonic muscle cells, 4028

Differentiation of human population Language boundaries and biological differentiation on Bougainville:

Multivariate analysis of variance, 2247 Differentiation, sexual

Influence of novel hypophyseal factor on steroid metabolism in cultured hepatoma cells, 4986

Diffusion Brownian motion in biological membranes, 3111 Effect of rotation on the diffusion-controlled rate of ligand-protein

association, 4918 Estimates of stratospheric pollution by analytic model, 4711 Magnetic resonance spectra of membranes, 1451 Moments for sum of an arbitrary function of gene frequency along a

stochastic path of gene frequency change, 1602 Dihydrolipoyl dehydrogenase

Reconstitution of Escherichia coli pyruvate dehydrogenase complex, 3068

Dihydro-orotase (EC 3.5.2.3) Reversible dissociation of carbamoyl phosphate synthase-aspartate

transcarbamoylase-dihydroorotase complex from ovarian eggs of Rana



20 Subject Index

catesbeiana: Effect of uridine triphosphate and other modifiers, 1712 Dihydropteroate synthase (EC 2.5.1.15)

Sulfonamide resistance mechanism in Escherichia coli:.R plasmids can determine sulfonamide-resistant dihydropteroate synthases, 2621

Dimethylsulfoxide Differentiation in erythroleukemic cells and their somatic hybrids, 98 Erythroid differentiation induced by dimethylsulfoxide in cells infected

with Friend virus: Relationship to cell cycle, 28 Induction of endogenous and of spleen focus-forming viruses during

dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus, 1863

Myelin structure transformed by dimethylsulfoxide, 3513 Purine metabolism in murine virus-induced erythroleukemic cells during

differentiation in vitro, 1630 Dinoflagellate

see Crypthecodinium (Gyrodinium) cohnii Dinucleotide fold


Dipalmitoyl-dimyristoylphosphatidylcholine bilayers Antagonistic effect of an inhalation anesthetic and high pressure on


Dipalmitoylphosphatidylcholine vesicle membrane Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by

concanavalin A, 4409 1,6-Diphenyl-1,3,5-hexatriene

Fluorescence polarization and viscosities of membrane lipids of 3T3 cells, 3351

2,3-Diphosphoglycerate Interaction of hemoglobin with three ligands: Organic phosphates and

Bohr effect, 2465 Diploidy

Enzyme activity, cell geometry, and fitness in Saccharomyces cerevisiae, 794

Diplometopon zarudnyi Amphisbaenian ear: Blanus cinereus and Diplometopon zarudnyi, 1487

Discoidin Cell surface species-specific high affinity receptors for discoidin:

Developmental regulation in Dictyostelium discoideum, 3541 Diseases of human beings

see end of this listing for diseases about which there is more than one paper

Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta, 586

Antibody nature of circulating inhibitor of plasma von Willebrand factor, 4167

Changes in cyclic nucleotide metabolism in aorta and heart of neurogenically hypertensive rats: Possible trigger mechanism of hypertension, 2135

Cytotoxic effector cells specific for B cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis, 1622

Factor-VIII-related antigen: Multiple molecular forms in human plasma, 5121

Fetal mouse hearts: Model for studying ischemia, 2809 Fetal mouse hearts: Model for studying ischemia (correction), 4679 Further comments on ascorbic acid requirement, 4151 Genetic heterogeneity in familial hypercholesterolemia: Two different

mutations affecting functions of low-density lipoprotein receptor, 1092 Immunological relationship between acetylcholine receptor and thymus:

A possible significance in myasthenia gravis, 1456 Increased concentrations of nonesterified arachidonic acid,

12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2, in epidermis of psoriasis, 5130


Interaction of glyoxal and methylglyoxal with biogenic amines, 1610 Introduction of enzymes, by immunoglobulin-coated liposomes, into

lysosomes of deficient cells, 88 Isolation of a low-molecular-weight serum component antigenically

related to an amyloid fibril protein of unknown origin, 1473 Locus on human X chromosome for dihydrotestosterone receptor and

androgen insensitivity, 1469 Mutation and childhood cancer: Probabilistic model for incidence of

retinoblastoma, 5116 Nonrandom chromosomal abnormalities in hematologic disorders of

man, 152 Patients with Ehlers-Danlos syndrome type IV lack type III collagen,

1314 Physiological role of an endoperoxide in human platelets: Hemostatic

defect due to platelet cyclo-oxygenase deficiency, 1446 Porphyria variegata and porphyria cutanea tarda in siblings: Chemical

and genetic aspects, 5126 Quantitative deficiency of chain-specific globin mRNA in thalassemia

syndromes, 567 Retarded rate of DNA chain growth in Bloom's syndrome, 758 Simian virus 40-related antigens in three human meningiomas with

defined chromosome loss, 609 Somatic rearrangement of chromosome 14 in human lymphocytes, 2071 Tay-Sachs' and Sandhoffs diseases: Assignment of genes for

hexosaminidase A and B to individual human chromosomes, 263 Diseases of human beings (alcoholism)

Experimental alcohol-induced hepatic necrosis: Suppression by propylthiouracil, 1137

Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets, 437


Diseases of human beings (cancer) Detection of carcinogens as mutagens in Salmonella/microsome test:

Assay of 300 chemicals, 5135 Mutation and childhood cancer: Probabilistic model for incidence of

retinoblastoma, 5116 New approach to antifolate treatment of certain cancers as demonstrated

in tissue culture, 4018 Oncornavirus-like particles in human skin cancers, 3697 Simian virus 40-related antigens in three human meningiomas with

defined chromosome loss, 609 Diseases of human beings (diabetes)


Synthesis of hemoglobin AIC in normal and diabetic mice: Potential model of basement membrane thickening, 3687

Diseases of human beings (familial hypercholesterolemia) Genetic heterogeneity in familial hypercholesterolemia: Two different

mutations affecting functions of low-density lipoprotein receptor, 1092 Receptor-dependent hydrolysis of cholesterol esters contained in plasma

low density lipoprotein, 2925 Diseases of human beings (Fanconi's anemia)


Retarded rate of DNA chain growth in Bloom's syndrome, 758 Diseases of human beings (gangliosidosis)

Electrophoretic variant of /-galactosidase with altered catalytic properties in patient with GM1 gangliosidosis, 240

Gene transfer to human cells: Transducing phage Xplac gene expression in GMi-gangliosidosis fibroblasts, 3531

Tay-Sachs' and Sandhoffs diseases: Assignment of genes for hexosaminidase A and B to individual human chromosomes, 263

Diseases of human beings (hepatitis) Experimental alcohol-induced hepatic necrosis: Suppression by

propylthiouracil, 1137 Lymphocyte cytotoxicity to autologous liver cells in chronic active

hepatitis, 1301 Sequential production of fatty liver, hepatitis, and cirrhosis in

sub-human primates fed ethanol with adequate diets, 437 Diseases of human beings (Hodgkin's disease)

Concanavalin A receptors on surface membrane of lymphocytes from patients with Hodgkin's disease and other malignant lymphomas, 104c


Diseases of human beings (Lesch-Nyhan syndrome) Hypoxanthine phosphoribosyltransferase deficiency: Association of

reduced catalytic activity with reduced levels of immunologically detectable enzyme protein, 4142

Radioimmune determination of hypoxanthine phosphoribosyltransferase crossreacting material in erythrocytes of Lesch-Nyhan patients, 4147

Diseases of human beings (leukemia) Growth and differentiation in culture of leukemic leukocytes from




Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis, 2804

Purification of RNA-instructed DNA polymerase from human leukemic spleens, 4133

RNA-directed DNA polymerase from human leukemic blood cells and from primate type-C virus-producing cells: High- and low-molecular-weight forms with variant biochemical and immunological properties, 1194

Search for nucleic acid sequences complementary to a murine oncornaviral genome in poly(A)-rich RNA of human leukemic cells, 4900

Somatic rearrangement of chromosome 14 in human lymphocytes, 2071 Viral-related information in oncornavirus-like particles isolated from


Diseases of human beings (methylmaalonicacidemia) [13C]Valine metabolism in methylmalonicacidemia using nuclear

magnetic resonance: Propionate as obligate intermediate, 3692 Genetic complementation in heterokaryons of human fibroblasts




Diseases of human beings (sickle cell disease) Bis(N-maleimidomethyl) ether: Antisickling reagent, 4153 Dimethyl adipimidate: New antisickling agent, 43 Isolation of antibodies specific to sickle hemoglobin by affinity

chromatography using a synthetic peptide, 4759 Quantitative deficiency of chain-specific globin mRNA in thalassemia

syndromes, 567 Diseases of human beings (thalassemia)

Demonstration of non-functional j-globin mRNA in homozygous /?-thalassemia, 5140

Expression of /-thalassemia gene in first trimester fetus, 3633 Human globin gene analysis for patient with fi//(i?-thalassemia, 2294 Imbalanced globin chain synthesis in heterozygous ,-thalassemic bone

marrow, 3853 Quantitative deficiency of chain-specific globin mRNA in thalassemia




syndromes, 567 Relative numbers of human globin genes assayed with purified a and /3

complementary human DNA, 1550 Synthesis of DNA complementary to separated human alpha and beta

globin messenger RNAs, 984 Diseases of human beings (xeroderma pigmentosum)

Genetic heterogeneity in xeroderma pigmentosum: Complementation groups and their relationship to DNA repair rates, 59

Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus), 4071



Disjunction property Disjunction property implies numerical existence property, 2877

Dissection time Circadian rhythm of neuron R15 of Aplysia californica: In vivo

photoentrainment, 2408 Dissipation bounds

Gross thermodynamics of heat engines in deep interior Earth, 1555 Disulfide

see also Sulfhydryl Antigen-induced conformational changes in antibodies and their Fab

fragments studied by circular polarization of fluorescence, 2775 Brdicka currents observed with bovine serum albumin and completely

reduced bovine serum albumin in presence of urea, 2044 Interchain disulfide bonds in procollagen are located in large

nontriple-helical COOH-terminal domain, 3009 Rapid and specific method for isolation of thiol-containing peptides from

large proteins by thiol-disulfide exchange on solid support, 3029 Structure and function of immunoglobulin domains: Studies with

beta2-microglobulin on role of intrachain disulfide bond, 548 DNA

see Deoxyribonucleic acid Donnan potential

Donnan potential of rabbit skeletal muscle myofibrils: I. Electrofluorochromometric detection of potential, 1325

L-Dopa d-Amphetamine disaggregates brain polysomes via a dopaminergic

mechanism, 834 Dopamine



Dopamine receptor binding in corpus striatum of mammalian brain, 4655 Effect of acetoxycycloheximide on rate of accumulation of cerebral

catecholamines from circulating tyrosine as related to its effect on memory, 479

Interaction of glyoxal and methylglyoxal with biogenic amines, 1610 Phenothiazine drugs: Structure-activity relationships explained by

conformation that mimics dopamine, 1899 Dopamine, 6-hydroxy-

Nerve growth factor induces volume increase and enhances tyrosine hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats, 595

Nerve growth factor induces volume increase and enhances tyrosine hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats (correction), 3261

Dopamine /f-monooxygenase Norepinephrine and related enzymes present in isolated brain

microvessels, 4622 Dopamine ,3-monooxygenase (EC 1.14.17.1)

Measurement of human dopamine-/-hydroxylase in serum by homologous radioimmunoassay, 750

Doughnut model of complement cytolysis Mechanism of cytolysis by complement: Insertion of C5b and C7


Drosophila Allozymic and chromosomal similarity in two Drosophila species, 4521 Linkage disequilibrium over space and time in natural populations of

Drosophila montana, 4095 Parallel changes in puffing activity and patterns of protein synthesis in

salivary glands of Drosophila, 3604 Statistical analyses of Drosophila and human protein polymorphisms,

3194 Drosophila melanogaster


Chromosome puff activity and protein synthesis in larval salivary glands of Drosophila melanogaster, 4550

Effect of insect hormones on RNA polymerases of mass-isolated imaginal discs of Drosophila melanogaster cultured in vitro, 2984


RNA from heat-induced polysomes at puff sites in Drosophila melanogaster, 1117

Drug see also specific drugs Brain receptors for antipsychotic drugs and dopamine: Direct binding

assays, 4376 Competitive protein binding assay for methotrexate, 3683

Subject Index 21

Lack of detectable change in cyclic AMP during&cardiac inotropic response to isoproterenol immobilized on glass beads, 824

Phenothiazine drugs: Structure-activity relationships explained by conformation that mimics dopamine, 1899

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs, 4863

Tumor-inhibiting properties of the neutral P-O-ethyl ester of adenosine 3':5'-monophosphate in correlation with its crystal and molecular structure, 1335 :

X-ray crystallographic visualization of drug-nucleic acid intercalative binding: Structure of an ethidium-dinucleoside monophosphate crystalline complex, ethidium: 5-'iodouridylyl(3'-5')adenosine, 628

Drug resistance see also Antibiotic resistance Plasmid-determined tetracycline resistance in Streptococcus faecalis:

Gene amplification during growth with tetracycline, 1720 Sulfonamide resistance mechanism in Escherichia coli: R plasmids can

determine sulfonamide-resistant dihydropteroate synthases, 2621 Drug tolerance

see also Narcotic dependence Dual regulation of adenylate cyclase accounts for narcotic dependence

and tolerance, 3092 Rapid changes in rat pineal /-adrenergic receptor: Alterations in

1-[3H]alprenolol binding and adenylate cyclase, 3735 Dynamics, nonlinear

Topological theorem for nonlinear dynamics in chemical and ecological networks, 2856

Dynamo Gross thermodynamics of heat engines in deep interior Earth, '1555 Theory of homogeneous dynamos in a rotating liquid sphere, 1496

Ear, amphisbaenian Amphisbaenian ear: Blanus cinereus and Diplometopon zarudnyi, 1487

Earth, deep interior Gross thermodynamics of heat engines in deep interior Earth, 1555

Earth's relief Stochastic models for Earth's relief, shape and fractal dimension of

coastlines, and number-area rule for islands, 3825 a-Ecdysone

Ovary as a source of a-ecdysone in an adult mosquito, 3255 Ecological network

Topological theorem for nonlinear dynamics in chemical and ecological networks, 2856

Ecological succession Feedback dynamics analysis of secondary successional transients in

ecosystems, 2733 Ecology


Group selection, altruism, reinforcement, and throwing in human evolution, 3748

South American mammal zoogeography: Convergent evolution in desert rodents, 1702

Species richness of parasitic fungi of British trees, 2116 Use of adenylate energy charge ratio to measure growth state of natural

microbial communities, 2112 Ecotropic property

Novel murine oncornavirus with dual eco- and xenotropic properties, 5150

Eddy diffusion Estimates of stratospheric pollution by analytic model, 4711

Edman degradation Homology in amino-terminal sequence of precursors to pancreatic

secretory proteins, 5016 Eel

see Electrophorus electricus Egg, amphibian

Repair of ultraviolet irradiation damage to cytoplasmic component required for neural induction in amphibian egg, 1235

Ehlers-,Danlos syndrome type IV Patients with Ehlers-Danlos syndrome type IV lack type III collagen,

1314 5,8,10,14-Eicosatetraenoic acid, 12L-hydroxy-


Eigenvalue, principal Variational formula for principal eigenvalue for operators with maximum

principle, 780 Elastin, glass point of

Glass point of elastin, 3505 Electrolectin

/-D-Galactoside binding protein from electric organ tissue of Electrophorus electricus, 1383

Electrolysis of water Photoassisted electrolysis of water by irradiation of a titanium dioxide

electrode, 1518 Electron

Possibility of a hydrodynamic model of the electron, 2037 Source theory analysis of electron-positron annihilation experiments,

4725 Electron donor/acceptor complexes

Raman resonance of electron donor/acceptor complexes, 4196 Electronic excitation

Collisional energy transfer and quenching of electronic excitation, 4205



22 Subject Index

Electron microscopy see also Freeze-etching; Freeze-fracture; Methodology (microscopy) Analysis of oncornavirus RNA subunits by electron microscopy, 3716 Architecture of Escherichia coli ribosome as determined by immune

electron microscopy, 4820 Chromatin architecture: Investigation of subunit of chromatin by dark

field electron microscopy, 2691 Electron microscope study of native and crosslinked rabbit muscle

phosphofructokinase, 3054 Electron microscopy of defined lengths of chromatin, 3320 Three-dimensional structure of herring sperm protamine Y-I with aid of

dark field electron microscopy, 4953 Use of gene 32 protein staining of single-strand polynucleotides for gene

mapping by electron microscopy: Application to 0(80d3ilv*u+7 system, 4506

Electron paramagnetic resonance see also Spin label Conformational change and cooperativity in actin filaments free of

tropomyosin, 3412 Differences in membrane fluidity and structure in contact-inhibited and

transformed cells (correction), 1217 Magnetic resonance spectra of membranes, 1451 Motion of subfragment-1 in myosin and its supramolecular complexes:

Saturation transfer electron paramagnetic resonance, 1729 Nuclear coupling of 33S and nature of free radicals in irradiated crystals

of cysteine hydrochloride and N-acetyl methionine, 3486 Primary acceptor in bacterial photosynthesis: Obligatory role of

ubiquinone in photoactive reaction centers of Rhodopseudomonas spheroides, 3491

Stabilization of electron spin resonance probes for photosynthesis studies, 3107

Triplet state in bacterial photosynthesis: Possible mechanisms of primary photo-act, 3270

Electron polarization, dynamic Chemically induced dynamic electron polarization in chloroplasts at

room temperature: Triplet state participation in photosynthesis, 4943 Electrons and nuclei

New approach to empirical intermolecular and conformational potential energy functions: I. Description of model and derivation of parameters, 543

Electron scattering Source theory discussion of deep inelastic scattering with polarized

particles, 1559 Electron spin polarization


Electron spin resonance see Electron paramagnetic resonance

Electron-transfer reaction Free radicals formed by exposure of pyrimidine solids to sodium atoms:

Electron spin resonance study, 974 Electron transport


Paired moving charges in mitochondrial energy coupling: II. Universality of principles for energy coupling in biological systems, 253

Primary acceptor in bacterial photosynthesis: Obligatory role of ubiquinone in photoactive reaction centers of Rhodopseudomonas spheroides, 3491

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution, 2305

Thylakoid membrane polypeptides of Chlamydomonas reinhardtii: Wild-type and mutant strains deficient in photosystem II reaction center, 2175

Electrophoresis see Gel electrophoresis; Immunoelectrophoresis; Methodology entries

Electrophorus electricus Acetylcholine-receptor-mediated ion flux in electroplax membrane

preparations, 4371 /-D-Galactoside binding protein from electric organ tissue of

Electrophorus electricus, 1383 Relaxation measurements on acetylcholine receptor, 3496

Electrophysiology Establishment of tight junctions between epithelial cells, 2711

Electrostatic force Spectator-ion effect on passage of ions through membranes, 683

Elongation, Escherichia coli Distinct penicillin binding proteins involved in the division, elongation,

and shape of Escherichia coli K12, 2999 Elongation factor

see also Protein synthesis Content of elongation factor Tu in Escherichia coli, 4780 Interaction of elongation factor Tu with

2'(3')-O-aminoacyloligonucleotides derived from the 3' terminus of aminoacyl-tRNA, 2950


Soluble protein identified that stimulates peptide bond synthesis, 4257 Embryo, avian


Coordinated motor output in hindlimb of 7-day chick embryo, 1245 Embryoid body

Differentiation of clonal lines of teratocarcinoma cells: Formation of embryoid bodies in vitro, 1441

Endocrine see also Hormone


Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats, 4033

Endodeoxyribonuclease (EC 3.1.4.30) Mutations simultaneously affecting endonuclease II and exonuclease III

in Escherichia coli, 688 Endonuclease

Adenosine diphosphate ribosylation of Ca2+, Mg2+-dependent endonuclease, 289

Endonucleolytic incision of x-irradiated deoxyribonucleic acid by extracts of Escherichia coli, 1997

Inverted repetitious sequences in the macronuclear DNA of hypotrichous ciliates, 678


Endonuclease II see Endodeoxyribonuclease (EC 3.1.4.30)

Endonuclease, restriction Bidirectional replication of plasmid R6K DNA in Escherichia coli:


Electrophoretic separation of Bacillus subtilis genes, 2207 Genome of hepatitis B virus: Restriction enzyme cleavage and structure

of DNA extracted from Dane particles, 4597 Herpes simplex virus DNA: Four populations of molecules that differ in

relative orientations of long and short components, 4243 Human papillomavirus DNA: Physical map, 4810 Influence of insertions on packaging of host sequences covalently linked

to bacteriophage Mu DNA, 4399 In vitro construction of bacteriophage X carrying segments of


Location of histones on simian virus 40 DNA, 2895 Restriction endonuclease analysis of mitochondrial DNA from grande

and genetically characterized cytoplasmic petite clones of Saccharomyces cerevisiae, 3868

Site-specific cleavage of single-stranded DNA by Hemophilus restriction endonuclease, 2555

Specific cleavage analysis of mammalian mitochondrial DNA, 4496 Specificity of substrate recognition by EcoRI restriction endonuclease,

3310 Transposition of R factor genes to bacteriophage X, 3628

Endonuclease, restriction, cleavage sites Anatomy of herpes simplex virus DNA: Strain differences and

heterogeneity in locations of restriction endonuclease cleavage sites, 1768


Genes, restriction sites, and DNA sequences surrounding 6S RNA template of bacteriophage X, 1817

Genes, restriction sites, and DNA sequences surrounding 6S RNA template of bacteriophage X (correction), 3753

Endoplasmic reticulum Cytochemical study of secretory process in transplantable insulinoma of

Syrian golden hamster, 4501 Endosymbiosis

Heme biosynthesis in bacterium-protozoon symbioses: Enzymic defects in host hemoflagellates and complemental role of their intracellular symbiotes, 2979


Prokaryotic nature of red algal chloroplasts, 2310 Endotoxin

see also Toxin Endotoxin-induced serum factor that causes necrosis of tumors, 3666

Energy budget Natural selection and evolution of reproductive effort, 2227

Energy coupling Paired moving charge model of energy coupling: III. Intrinsic ionophores

in energy coupling systems, 896 Paired moving charges in mitochondrial energy coupling: II. Universality

of principles for energy coupling in biological systems, 253 Ubiquinone-mediated coupling of NADH dehydrogenase to active

transport in membrane vesicles from Escherichia coli, 3970 Energy function, empirical

New approach to empirical intermolecular and conformational potential energy functions: I. Description of model and derivation of parameters, 543

Energy, intermolecular interaction New approach to empirical intermolecular and conformational potential


Energy minimization Assessment of some problems associated with prediction of


Energy, solar Photoassisted electrolysis of water by irradiation of a titanium dioxide

electrode, 1518 Reaction of tris(bipyridine)ruthenium(III) with hydroxide and its

application in a solar energy storage system, 2858 Energy storage

Reaction of tris(bipyridine)ruthenium(III) with hydroxide and its application in a solar energy storage system, 2858

Energy transfer Collisional energy transfer and quenching of electronic excitation, 4205




Distribution of end-to-end distances of oligopeptide in solution estimated by energy transfer, 1807

Energy transfer between terbium(III) and cobalt(II) in thermolysin: New class of metal-metal distance probes, 4764

Enterobacter aerogenes see Aerobacter aerogenes

Entrainment Control of oscillating glycolysis of yeast by stochastic, periodic, and

steady source of substrate: Model and experimental study, 3829 Entropy

Partial knowledge, entropy, and estimation, 3819 Enucleation

Biochemical lesions used for selection of human cells with hybrid cytoplasms, 1812

Envelope structure of Escherichia coli Alterations in envelope structure of heptose-deficient mutants of

Escherichia coli as revealed by freeze-etching, 5145 Environmental science


Enzymatic breaking of deoxyribonucleic acid Enzymatic induction of DNA double-strand breaks in y-irradiated

Escherichia coli K-12, 4265 Enzyme

see also specific enzymes; Catalysis; Ligand; Protein Enzyme, allosteric

Quaternary constraint in hybrid of aspartate transcarbamylase containing wild-type and mutant catalytic subunits, 4298

Enzyme as reagent Enzymes as reagents in peptide synthesis: Enzymatic removal of amine

protecting groups, 2193 Enzyme, autolytic

Lipoteichoic acid: Specific inhibitor of autolysin activity in pneumococcus, 1690

Enzyme complex Aggregated multienzyme system influences transient time: Kinetic

evidence for compartmentation by aromatic-amino-acid-synthesizing complex of Neurospora crassa, 4218


Enzyme, constitutive In vitro synthesis of constitutive enzyme of Escherichia coli,

6-phosphogluconate dehydrogenase, 4381 Enzyme deficiency

Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes in culture, 5026

Enzyme I Interaction of enzyme I of the phosphoenolpyruvate:sugar


Enzyme induction Autogenous regulation of inducible tryptophan synthase of Pseudomonas

putida, 1249 Circadian rhythm of tyrosine hydroxylase induction by short-term cold


Genetic control of endosperm amylase activity and gibberellic acid responses in standard-height and short-statured wheats, 892

Genetic evidence on organization and action of qa-1 gene product: Protein regulating induction of three enzymes in quinate catabolism in Neurospora crassa, 553

Regulation of synthesis of hepatic fatty acid synthetase: Binding of fatty acid synthetase antibodies to polysomes, 3956

Enzyme inhibition, competitive Resonance Raman spectroscopic studies of interactions between trypsin

and competitive inhibitor, 4223 Enzyme, large-subunit

Partial amino-acid sequence of NAD-specific glutamate dehydrogenase of Neurospora crassa, 4891

Enzyme, lysosomal Fetal mouse hearts: Model for studying ischemia, 2809 Fetal mouse hearts: Model for studying ischemia (correction), 4679 Lymphokine-induced production and release of lysosomal enzymes by

macrophages, 2091 Enzyme mechanism

Activation volumes in enzymic catalysis: Their sources and modification by low-molecular-weight solutes, 3014

Catalysis by acetylcholinesterase: Evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis, 3834

Extraordinary dielectric properties of biological materials and action of enzymes, 4211

Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase A: Monitor of multiple conformational states in solution, 4356

Molecular orbital studies of enzyme activity: Charge relay system and tetrahedral intermediate in acylation of serine proteinases, 2606

Phenylalanyl-tRNA synthetase from baker's yeast: Role of 3'-terminal adenosine of tRNAPhe in enzyme-substrate interaction studied with 3'-modified tRNAPhe species, 1378

Enzyme, membrane-bound Antigenic and enzymatic architecture of Micrococcus lysodeikticus

membranes established by crossed immunoelectrophoresis, 3711 Apparent dependence of interactions between cytochrome ba and


Apparent dependence of interactions between cytochrome b5 and

Subject Index 23

cytochrome b5 reductase upon translational diffusion in dimyristoyl lecithin liposomes (correction), 4679

Enzyme, microsomal Sequential production of fatty liver, hepatitis, and cirrhosis in

sub-human primates fed ethanol with adequate diets, 437 Enzyme regulation

Guanosine metabolism and regulation of fruiting body construction in Dictyostelium discoideum, 4479

Inhibition of citrate synthase by oleoyl-CoA: Regulatory phenomenon, 4729


Enzyme solubilization Yeast manno-protein biosynthesis: Solubilization and selective assay of

four mannosyltransferases, 3912 Enzyme structure

see also Protein structure Structural properties of pyruvate carboxylases from chicken liver and

other sources, 4308 Enzyme synthesis

see Enzyme regulation; Protein synthesis Enzyme translocation across membranes

Translocation of 5'-nucleotidase across hepatic membranes in vivo, 4013 Enzymic cleavage of ribosomal precursor

Ribonucleoprotein precursor of both the 30S and 50S ribosomal subunits of Escherichia coli, 1533

Eosinophil chemotactic factor of anaphylaxis Purification and synthesis of eosinophilotactic tetrapeptides of human


Epidermal growth factor Human epidermal growth factor: Isolation and chemical and biological

properties, 1317 Epinephrine

Cellular levels of feedback regulator of adenylate cyclase and effect of epinephrine and insulin, 4739

Human synoviocytes: Activation and desensitization by prostaglandins and l-epinephrine, 3124

Stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol: Effect of cholera toxin, 3561

Epithelial sheet Contact inhibition of phagocytosis in epithelial sheets: Alterations of cell

surface properties induced by cell-cell contacts, 719 Epstein-Barr virus

Cytotoxic effector cells specific for B cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis, 1622

Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus, 3206

Growth characteristics of Epstein-Barr virus (EBV)-genome-negative lymphoma line and its EBV-converted subline in vitro, 3518

Oncornavirus-like particles released from arginine-deprived human lymphoblastoid cell lines, 4592


Epstein-Barr virus genome Epstein-Barr virus genomes with properties of circular DNA molecules

in carrier cells, 1477 Equimultiple subvariety

On equimultiple subvarieties of algebroid hypersurfaces, 1425 On equimultiple subvarieties of algebroid hypersurfaces (correction),

3260 Errata

see Corrections Erythrocruorin

Kinetics of binding of carbon monoxide to Lumbricus erythrocruorin: A possible model, 4313

Erythrocyte Differentiation of peripheral blood lymphocytes into cells bearing sheep

erythrocyte receptors in vitro by human thymic extract, 1175 Erythrocyte rosette


Binding of autologous erythrocytes to immature T-cells, 3201 Erythroid colony induction

Erythroid colony induction without erythropoietin by Friend leukemia virus in vitro, 3556

Erythromycin A (Oligo)peptidyl-tRNA released from ribosomes by erythromycin A, 2649

Erythropoietin Erythroid colony induction without erythropoietin by Friend leukemia

virus in vitro, 3556 Testosterone stimulation of rapidly labeled, low-molecular-weight RNA

fraction in human hepatic erythroid cells in culture, 523 Escherichia coli

Alterations in envelope structure of heptose-deficient mutants of Escherichia coli as revealed by freeze-etching, 5145

Biogenesis of membrane lipids: Mutants of Escherichia coli with temperature-sensitive phosphatidylserine decarboxylase, 1112

Content of elongation factor Tu in Escherichia coli, 4780 Dissociation of ribosomes of Escherichia coli by initiation factor IF-3,

4238 Distinct penicillin binding proteins involved in the division, elongation,

and shape of Escherichia coli K12, 2999 DNA strand breaks measured within 100 milliseconds of irradiation of

Escherichia coli by 4 MeV electrons, 167



24 Subject Index

Effect of growth conditions on DNA-membrane attachment in Escherichia coli, 2446


*

Fusion of Escherichia coli lac genes to ara promoter: Bacteriophage mu-1 insertions, 809

Inducible error-prone repair in Escherichia coli, 2753 Induction of error-prone repair as consequence of DNA ligase deficiency

in Escherichia coli, 4645 Interaction of Escherichia coli dnaB and dnaC(D) gene products in

vitro, 921 Low-molecular-weight DNA-binding protein, Hi factor, affects in vitro

transcription of lactose operon in Escherichia coli, 333 Mating signal and DNA penetration deficiency in conjugation between

male Escherichia coli and minicells, 3721 Methionine in bacterial chemotaxis: Requirement for tumbling and

involvement in information processing, 4640 Novel, low-molecular-weight DNA-binding protein from Escherichia

coli, 3428 Novel mutants of Escherichia coli that accumulate very small DNA

replicative intermediates, 2150 Permeability lesions in male Escherichia coli infected with

bacteriophage T7, 2222 Presence of polyriboadenylate sequences in pulse-labeled RNA of

Escherichia coli, 2910 Proposal concerning mechanism of evolution of the genome of

Escherichia coli, 1354 Regulation of RNA polymerase synthesis in Escherichia coli: Mutant

unable to synthesize enzyme at 43?, 911 Sequential processing of precursor tRNA molecules in Escherichia coli,

3369 Specialized transducing phages for ribosomal protein genes of

Escherichia coli, 6 Sulfonamide resistance mechanism in Escherichia coli: R plasmids can

determine sulfonamide-resistant dihydropteroate synthases, 2621 Transient response to chemotactic stimuli in Escherichia coli, 3235 Viability of Escherichia coli treated with colicin K, 4631

Escherichia coli chromosome Identification of gene for the a-subunit of RNA polymerase at the

str-spc region of Escherichia coli chromosome, 5036 Escherichia coli, division

Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12, 2999

Escherichia coli genome Biochemical construction and selection of hybrid plasmids containing

specific segments of Escherichia coli genome, 4361 Escherichia coli, membrane

Active transport of calcium in inverted vesicles of Escherichia coli (correction), 2833

Esterase Linkage disequilibrium over space and time in natural populations of '

Drosophila montana, 4095 Estimation

Partial knowledge, entropy, and estimation, 3819 Estradiol

Estradiol-17/ affects synthesis of specific uterine nonhistone chromosomal proteins, 4346

Follicle-stimulating hormone stimulates estradiol-17/ synthesis in cultured Sertoli cells, 2677

Synthesis of vitellogenin in cultures of male and female frog liver regulated by estradiol treatment in vitro, 3172

Estrogen Androgen- and estrogen-binding macromolecules in developing mouse

brain: Biochemical and genetic evidence, 4303 Effect of estrogen on gene expression: Purification of vitellogenin

messenger RNA, 3364 Estradiol-17/ affects synthesis of specific uterine nonhistone

chromos6mal proteins, 4346 Estrogen affects gene expression in chick oviduct: Nuclear receptor levels

and initiation of transcription, 4228 Estrogen-directed synthesis of specific prostaglandins in uterus, 1420 Steroidogenesis in rabbit preimplantation embryos, 298 Translation of hormone-induced messenger RNA in amphibian oocytes:

Induction by estrogen of messenger RNA encoded for vitellogenic protein in liver of male African clawed toad (Xenopus laevis), 3934

"Estrogen-induced" protein Separation of "estrogen-induced" protein from phosphoprotein

phosphatase activity of immature rat uterus, 2631 Estrus

Body weight and food intake at early estrus of rats on high-fat diet, 4172 Estuarine sediment

Use of adenylate energy charge ratio to measure growth state of natural microbial communities, 2112

Ethanol Experimental alcohol-induced hepatic necrosis: Suppression by

propylthiouracil, 1137 Ethidium bromide

Cellular protein synthesis required in reversal of ethidium-bromide-induced inhibition of cell transformation by murine sarcoma virus, 4337

Determination of number of superhelical turns in simian virus 40 DNA by gel electrophoresis, 4876

Interaction of fl histone with superhelical DNA, 2597 Purified DNA-relaxing enzyme from human tissue culture cells, 2550

Ethidium: 5-iodouridylyl(3'-5')adenosine X-ray crystallographic visualization of drug-nucleic acid intercalative

binding: Structure of an ethidium-dinucleoside monophosphate crystalline complex, ethidium: 5-iodouridylyl(3'-5')adenosine, 628


Euchromatin Separation of lymphocyte chromatin into template-active fractions with


Eugenol, methyl Oriental fruit fly, Dacus dorsalis, attracted to methyl eugenol and

related olfactory stimulants, 2501 Euglena gracilis

NADPH-thioredoxin reductase system identified in Euglena gracilis, 4233


Euler-Lagrange equation Deduction of semi-optimal mollifier for obtaining lower bound for No(T)

for Riemann's zeta-function, 294 Euler-Poincare principle

Dedekind's 7-function and cohomology of infinite dimensional Lie algebras, 2493

Evolution, chromosomal and genetic Allozymic and chromosomal similarity in two Drosophila species, 4521 Enzyme activity, cell geometry, and fitness in Saccharomyces cerevisiae,

794 Evolutionary changes in mating system of experimental population of

barley (Hordeum vulgare L.), 943 General kin selection models for genetic evolution of sib altruism in

diploid and haplodiploid species, 4531 Proposal concerning mechanism of evolution of the genome of

Escherichia coli, 1354 Slow evolutionary loss of potential for interspecific hybridization in

birds: Manifestation of slow regulatory evolution, 200 Social structuring of mammalian populations and rate of chromosomal

evolution, 5061 Evolution, early fossil

Abiotic, graphitic microstructures in micaceous metaquartzite about 3760 million years old from Southwestern Greenland: Early Precambrian microfossils, 1206

Nonprevalence of biochemical fossils in kerogen from pre-Phanerozoic sediments, 4706

Evolution, molecular Acetylcholine receptors at neuromuscular synapses: Phylogenetic

differences detected by snake a-neurotoxins, 3245 Allozymic and chromosomal similarity in two Drosophila species, 4521 Evolution of biosynthetic pathways: Immunological approach, 1268 Evolution of type C viral genes: Preservation of ancestral murine type C

viral sequences in pig cellular DNA, 4090 Further comments on ascorbic acid requirement, 4151 Heme biosynthesis in bacterium-protozoon symbioses: Enzymic defects

in host hemoflagellates and complemental role of their intracellular symbiotes, 2979

Homology and relationship between genomes of papovaviruses, BK virus and simian virus 40, 2563

Interlocus variation of genetic distance and neutral mutation theory, 2758


Pituitary growth hormones: Evolutionary conservatism based on immunochemical studies, 4322

Prokaryotic nature of red algal chloroplasts, 2310 Site of aminoacylation of tRNAs from Escherichia coli with respect to

2'- or 3'-hydroxyl group of terminal adenosine, 3049 Slow evolutionary loss of potential for interspecific hybridization in

birds: Manifestation of slow regulatory evolution, 200 Temporal fluctuation of selection coefficient affects gene frequency in a

population, 4541 Evolution, organismal and social

General kin selection models for genetic evolution of sib altruism in diploid and haplodiploid species, 4531

Group selection, altruism, reinforcement, and throwing in human evolution, 3748

Slow evolutionary loss of potential for interspecific hybridization in birds: Manifestation of slow regulatory evolution, 200

Social structuring of mammalian populations and rate of chromosomal evolution, 5061


Evolution, theoretical and mathematical treatments General kin selection models for genetic evolution of sib altruism in

diploid and haplodiploid species, 4531 Group selection, altruism, reinforcement, and throwing in human

evolution, 3748 Life games and statistical models, 956 Natural selection and evolution of reproductive effort, 2227 Temporal fluctuation of selection coefficient affects gene frequency in a

population, 4541 Theory of evolution above the species level, 646

Excision of prophage Excision of prophage A in cell-free system, 2188

Excision repair see also Deoxyribonucleic acid repair Endonucleolytic incision of x-irradiated deoxyribonucleic acid by

extracts of Escherichia coli, 1997 Enzymatic induction of DNA double-strand breaks in y-irradiated

Escherichia coli K-12, 4265 Xeroderma pigmentosum cells with normal levels of excision repair have

defect in DNA synthesis after UV-irradiation, 219 Exhaustion function

Exhaustion functions and Stein neighborhoods for smooth pseudoconvex domains, 3279




Existence theorem Strongly nonlinear integral equations of Hammerstein type, 1937

Exodeoxyribonuclease III (EC 3.1.4.27) Mutations simultaneously affecting endonuclease II and exonuclease III

in Escherichia coli, 688 Exonuclease III

see Exodeoxyribonuclease III (EC 3.1.4.27) Exotoxin

see Toxin Eye-opening

Development of receptive fields in rabbit visual cortex: Changes in time course due to delayed eye-opening, 1543

Eye, role in photoentrainment Circadian rhythm of neuron R15 of Aplysia californica: In vivo

photoentrainment, 2408

Fab fragment Antigen-induced conformational changes in antibodies and their Fab

fragments studied by circular polarization of fluorescence, 2775 Factor VIII


Factor-VIII-related antigen Factor-VIII-related antigen: Multiple molecular forms in human plasma,

5121 Factor X

Activation of bovine factor X (Stuart factor): Conversion of factor Xaa to factor Xaj, 3359


Bovine factor X1 (Stuart factor): Primary structure of light chain, 16 Isolation and characterization of vitamin K-dependent region of bovine

blood clotting factor X, 1281 Fanconi's anemia


Retarded rate of DNA chain growth in Bloom's syndrome, 758 Fatness, critical

Body weight and food intake at early estrus of rats on high-fat diet, 4172 Fatty acid

Conjugated polyene fatty acids as membrane probes, 1649 Fatty acid chain flexibility in membranes of normal and transformed

fibroblasts, 664 Fatty acids as modulators of membrane functions:

Catecholamine-activated adenylate cyclase of turkey erythrocyte, 3433 Inhibition of citrate synthase by oleoyl-CoA: Regulatory phenomenon,

4729 Mitochondrial carnitine acylcarnitine translocase system, 883 Role of carnitine in hepatic ketogenesis, 4385 Separation of 1-acylglycerolphosphate acyltransferase and


Fatty acid oxygenase Structural requirements for time-dependent inhibition of prostaglandin

biosynthesis by anti-inflammatory drugs, 4863 Fatty acid synthetase

Regulation of synthesis of hepatic fatty acid synthetase: Binding of fatty acid synthetase antibodies to polysomes, 3956

Regulation of synthesis of hepatic fatty acid synthetase: Polysomal translation in cell-free system, 4366

Two polypeptide chains comprising fatty acid synthetase, 1940 Feedback

see also Regulation Feedback dynamics analysis


Feedback regulator Action of feedback regulator on adenylate cyclase, 1773 Cellular levels of feedback regulator of adenylate cyclase and effect of

epinephrine and insulin, 4739 Feeding

see also Diet; Food intake; Nutritional response Chemoreceptors and feeding in calanoid copepods (Arthropoda:

Crustacea), 4185 Control of meal size by central noradrenergic action, 3740

Ferrate(III), bis(o-xylyldithiolato)- Synthetic analogs of active sites of iron-sulfur proteins:


Ferredoxin Acid-base properties, hydrolytic mechanism, and susceptibility to 02

oxidation of Fe4S4(SR)4-2 clusters, 231 Iron-sulfur clusters: Ligand exchange kinetics studied on water-soluble

Fe4S4(SR)4n- cluster, 2478 NH...S Hydrogen bonds in Peptococcus aerogenes ferredoxin,

Clostridium pasteurianum rubredoxin, and Chromatium high potential iron protein, 4854

Regulation of ferredoxin-catalyzed photosynthetic phosphorylations, 4961

Ferric ethylenediaminetetraacetate complex Decomposition of hydrogen peroxide catalyzed by ferric

ethylenediaminetetraacetate complex, 140 Ferritin-insulin complex

Ultrastructural localization of insulin receptors on adipocytes, 3526 Fertilization


Subject Index 25


Fetus, first trimester Expression of /-thalassemia gene in first trimester fetus, 3633

Fibrinolysis Plasminogen-independent fibrinolysis by proteases produced by

transformed chick embryo fibroblasts, 1132 Fibroblast, binucleate


Fibroblast, chick embryo Major cell surface glycoprotein of chick embryo fibroblasts is an

agglutinin, 3158 Mitogenic activity of blood components: I. Thrombin and prothrombin,

131 Plasminogen-independent fibrinolysis by proteases produced by

transformed chick embryo fibroblasts, 1132 Stimulus to DNA synthesis in cultures of chick embryo cells is

nonspecific, 1676 Fibroblast, GMi-gangliosidosis


Fibroblast growth Human epidermal growth factor: Isolation and chemical and biological

properties, 1317 Fibroblast, mononucleate


Fibroblast, mouse Cyclic AMP and cyclic GMP concentrations in serum- and

density-restricted fibroblast cultures, 1063 Initiation of cell proliferation in cultured mouse fibroblasts by

prostaglandin F2a, 2724 Fibroblast, transformed


Fatty acid chain flexibility in membranes of normal and transformed fibroblasts, 664

Formation of bone marrow in fibroblast-transformation ossicles, 2212 Field ionization

Scanning transmission ion microscope with field ion source, 1826 Filament

Conformational change and cooperativity in actin filaments free of tropomyosin, 3412

Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells, 4483

Filamin Filamin, a new high-molecular-weight protein found in smooth muscle

and non-muscle cells, 4483 Finite difference

Point estimates for probability moments, 3812 Fireball, primordial

Progress and prospects in high energy astrophysics, 4685 Fish

see Cichlid fish; Electrophorus; Torpedo Flagellum

Assembly of chick brain tubulin onto flagellar microtubules from Chlamydomonas and sea urchin sperm, 1122

Molecular mechanism for oscillation in flagella and muscle, 3102 Flash photolysis

Functional intermediates in reaction of cytochrome oxidase with oxygen, 1635

Flavin Bacterial luciferase requires one reduced flavin for light emission, 3374 Interaction of ubisemiquinone with a paramagnetic component in heart

tissue, 2886 Radical mechanisms for 1,5-dihydroflavin reduction of carbonyl

compounds, 1763 Flavoprotein

NADPH:thioredoxin reductase system identified in Euglena gracilis, 4233

Floquet theory On some periodic Toda lattices, 1627

Flow, pressure-induced General model for osmotic and pressure-induced flow in plant roots,

3114 Flow system

Chromosome measurement and sorting by flow systems, 1231 Fluctuation

Matrix method for fluctuations and noise in kinetic systems, 3807 Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams,

1291 Fluid, slightly compressible

Motion of a slightly compressible fluid, 539 Fluorescamine


Fluorescence Energy transfer between terbium(III) and cobalt(II) in thermolysin: New

class of metal-metal distance probes, 4764 Kinetics of action of pepsin on fluorescent peptide substrates, 3424

Fluorescence depolarization spectroscopy, nanosecond Sigma cycle during in vitro transcription: Demonstration by nanosecond

fluorescence depolarization spectroscopy, 3019 Fluorescence polarization

Antigen-induced conformational changes in antibodies and their Fab fragments studied by circular polarization of fluorescence, 2775



26 Subject Index


Fluorescence quenching Dynamic and static quenching of 1,N6-ethenoadenine fluorescence in

nicotinamide 1,N6-ethenoadenine dinucleotide and in 1,N6-etheno-9- [3-(indol-3-yl)propyl]adenine, 3966

Dynamics of protein matrix revealed by fluorescence quenching, 3290 Fluorescent probe

Crosslinking and labeling of membrane proteins by transglutaminase-catalyzed reactions, 2568

1-Pyrene-butyrylcholine: A fluorescent probe for the cholinergic system, 3097

Flux Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams,

1291 Folate binding factor

Folate binding factor in normal umbilical cord serum purified, 4261 Folate, 5-methyltetrahydro-

New approach to antifolate treatment of certain cancers as demonstrated in tissue culture, 4018

Follicle stimulating hormone see Follitropin

Follitropin Follicle-stimulating hormone or dibutyryl cyclic AMP induces structural

changes on presumptive Sertoli cells in culture, 1838 Follicle-stimulating hormone stimulates estradiol-17f/ synthesis in

cultured Sertoli cells, 2677 Food intake

see also Feeding Body weight and food intake at early estrus of rats on high-fat diet, 4172

N-Formylmethionyl peptides N-Formylmethionyl peptides as chemoattractants for leucocytes, 1059

Fossil see also Microfossil

Fossil, biochemical Nonprevalence of biochemical fossils in kerogen from pre-Phanerozoic

sediments, 4706 Fossil gene

Evolution of type C viral genes: Preservation of ancestral murine type C viral sequences in pig cellular DNA, 4090

Fourier transform Inequalities in Fourier analysis on Rn, 638

Fracture face Membrane particles on fracture faces of frozen myelin, 4046

Frechet space Connectivities Ri of Frechet spaces in variational topology, 2069

Fredholm theory Inequality among determinants, 3277

Free energy, contact Model of protein folding: Inclusion of short-, medium-, and long-range

interactions, 3802 Free radical

Free radicals formed by exposure of pyrimidine solids to sodium atoms: Electron spin resonance study, 974

Nuclear coupling of 33S and nature of free radicals in irradiated crystals of cysteine hydrochloride and N-acetyl methionine, 3486

Freeze-etching Alterations in envelope structure of heptose-deficient mutants of

Escherichia coli as revealed by freeze-etching, 5145 Freeze-fracture

Membrane particles on fracture faces of frozen myelin, 4046 Structural change of plasma membrane induced by oncogenic viruses:

Quantitative studies with freeze-fracture technique, 1695 Frog

see Rana; Xenopus Fructose 1,6-bisphosphatase (EC 3.1.3.11)

Hormonal effects on structure and catalytic properties of fructose 1,6-bisphosphatase, 2969

Fruit fly see Dacus; Drosophila

Fruiting body Guanosine metabolism and regulation of fruiting body construction in

D;ftv..,stelilm discoideum, 4479 1 (-i'.1,1 il ,il (development in Myxococcus xanthus: Effect of 3':5'-cyclic

AMP, ADP, and nutrition, 518 Fungus

see also Blastocladiella; Coelomomyces; Mucor; Neurospora; Saccharomyces; Ustilago

Inherited "neoplasm" in a fungus, 4626 Mutations affecting sexual development in Phycomyces blakesleeanus,

127 Species richness of parasitic fungi of British trees, 2116

Galactic nucleus, exploding Progress and prospects in high energy astrophysics, 4685

Galactose Binding protein-independent substrate translocation by

methylgalactoside transport system of Escherichia coli K12, 423 /-Galactosidase

Electrophoretic variant of 3-galactosidase with altered catalytic properties in patient with GM1 gangliosidosis, 240

/3-Galactosidase (EC 3.2.1.23) Adenosine 3':5'-cyclic monophosphate as mediator of catabolite

repression in Escherichia coli, 2300 Gene transfer to human cells: Transducing phage Aplac gene expression

in GMi-gangliosidosis fibroblasts, 3531 Molecular basis of /-galactosidase a-complementation, 1254


#-D-Galactoside Binding protein-independent substrate translocation by

methylgalactoside transport system of Escherichia coli K12, 423 /-D-Galactoside binding protein from electric organ tissue of

Electrophorus electricus, 1383 Galaxy



Progress and prospects in high energy astrophysics, 4685 Games, life

Life games and statistical models, 956 Gametogenesis

Selection for conditional gametogenesis in Chlamydomonas reinhardi, 3652

Ganglion Cytochemical studies of Golgi apparatus, GERL, and lysosomes in

neurons of dorsal root ganglia in mice, 508 Effect of nerve growth factor on cyclic AMP levels in superior cervical

ganglia of rat, 4769 Ganglioside

Electrophoretic variant of /-galactosidase with altered catalytic properties in patient with GM1 gangliosidosis, 240


Mobility of cholera toxin receptors on rat lymphocyte membranes, 3844 Gangliosidosis

Electrophoretic variant of f-galactosidase with altered catalytic properties in patient with GM1 gangliosidosis, 240



Gap junction Distribution of membrane particles and gap junctions in normal and

transformed 3T3 cells studied in situ, in suspension, and treated with concanavalin A, 572

Gastric mucosa, canine Titration of sodium channels in canine gastric mucosa, 3731

Gel electrophoresis see also Methodology entries Determination of number of superhelical turns in simian virus 40 DNA

by gel electrophoresis, 4876 Gelfand-Levitan procedure

Well-posed inverse spectral problems, 2496 Gene

see also Operon Gene, A

Isolation of bacteriophage lambda A-gene protein, 581 Gene, Akv-1

Murine C-type virus inducing locus Akv-1 is viral genetic material, 906 Gene, bac, bacteriophage P1

,kX174 DNA-dependent DNA synthesis in vitro: Requirement for P1 ban protein in dnaB mutant extracts of Escherichia coli, 3907

Gene, dnaS Novel mutants of Escherichia coli that accumulate very small DNA

replicative intermediates, 2150 Gene, H-2, complex

H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice, 5095

Gene, Ir, H- 21-linked Complementation of H-2-linked Ir genes in mouse, 3671

Gene, lac Fusion of Escherichia coli lac genes to ara promoter: Bacteriophage

mu-l insertions, 809 Gene, lex

Model for regulation of Escherichia coli DNA repair functions, 2330 Gene, polAl, mutation


Gene, qa-1 Genetic evidence on organization and action of qa-1 gene product:

Protein regulating induction of three enzymes in quinate catabolism in Neurospora crassa, 553

Gene, recA Model for regulation of Escherichia coli DNA repair functions, 2330 Site-specific recA-independent recombination between bacterial

plasmids: Involvement of palindromes at the recombinational loci, 1373

Gene, suA Transcription termination factor rho activity is altered in Escherichia

coli with suA gene mutations, 1725 Gene, xth, mutation

Mutations simultaneously affecting endonuclease II and exonuclease III in Escherichia coli, 688

Gene, bacteriophage Aplac Gene transfer to human cells: Transducing phage Aplac gene expression

in GMi-gangliosidosis fibroblasts, 3531 Gene, chromosome location

New chromosomal location for structural genes of ribosomal proteins, 2765

Gene conversion Mismatch repair in heteroduplex DNA, 2202

Gene dosage Gene dosage: Assignment of erythrocyte acid phosphatase locus to

chromosome 2, 4526 Human globin gene analysis for patient with ?/^/3?-thalassemia, 2294




Gene duplication Proposal concerning mechanism of evolution of the genome of

Escherichia coli, 1354 Repetitive hinge region sequences in human IgG3: Isolation of an

11,000-dalton fragment, 723 Site-specific recA-independent recombination between bacterial


Gene, electrophoretic separation Electrophoretic separation of Bacillus subtilis genes, 2207

Gene expression Bacterial mutation blocking P2 phage late gene expression, 2770 Correlated suppression by 5-bromodeoxyuridine of tumorigenicity and

plasminogen activator in mouse melanoma cells, 47 Effect of estrogen on gene expression: Purification of vitellogenin

messenger RNA, 3364 Estrogen affects gene expression in chick oviduct: Nuclear receptor levels

and initiation of transcription, 4228 Gene expression in mouse neuroblastoma cells: Properties of the genome,

3119 Parallel changes in puffing activity and patterns of protein synthesis in

salivary glands of Drosophila, 3604 Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes

in culture, 5026 Gene frequency

Moments for sum of an arbitrary function of gene frequency along a stochastic path of gene frequency change, 1602

Temporal fluctuation of selection coefficient affects gene frequency in a population, 4541

Gene induction Hemoglobin synthesis in somatic cell hybrids: Coexpression of mouse

with human or Chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells, 2682

Gene interaction Inherited "neoplasm" in a fungus, 4626

Gene mapping Chromosome puff activity and protein synthesis in larval salivary glands

of Drosophila melanogaster, 4550 Human gene expression in rodent cells after uptake of isolated

metaphase chromosomes, 1797 Human papillomavirus DNA: Physical map, 4810 Human X-linked genes regionally mapped utilizing X-autosome

translocations and somatic cell hybrids, 2125 Mapping mutational alterations in DNA with S1 nuclease: Location of

deletions and temperature-sensitive mutations in simian virus 40, 989 Mapping of biological functions on RNA of avian tumor viruses:



Meiosis in Phycomyces, 4076 New chromosomal location for structural genes of ribosomal proteins,

2765 T antigen binds to simian virus 40 DNA at the origin of replication, 1605 Use of gene 32 protein staining of single-strand polynucleotides for gene

mapping by electron microscopy: Application to 80d3ilvsu+7 system, 4506

Visualization of novel junction in bacteriophage X DNA, 3024 Gene, of ribosomal protein


Gene 32 protein Genetic evidence for an additional function of phage T4 gene 32 protein:

Interaction with ligase, 1226 Use of gene 32 protein staining of single-strand polynucleotides for gene


Gene regulation Effects of guanosine tetraphosphate on cell-free synthesis of Escherichia

coli ribosomal RNA and other gene products, 2881 Fusion of Escherichia coli lac genes to ara promoter: Bacteriophage

mu-1 insertions, 809 Hemoglobin synthesis in somatic cell hybrids: Globin gene expression in


Hemoglobin synthesis in somatic cell hybrids: Coexpression of mouse with human or Chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells, 2682

Histidine regulation in Salmonella typhimurium: Activator-attenuator model of gene regulation, 3453

Mutant hamster cells exhibiting pleiotropic effect on carbohydrate metabolism, 469


Nucleotide sequence of rightward operator of phage A, 1184 Regulation of histidine operon does not require hisG enzyme, 5021 Specific human B lymphocyte alloantigens linked to HL-A, 5103

Gene, R factor Transposition of R factor genes to bacteriophage A, 3628

Genetic analysis Genetic analysis in dinoflagellate Crypthecodinium (Gyrodinium)

cohnii: Unusual meiosis, 4546 Genetic code

Co-evolution theory of genetic code, 1909 Genetic defect


Subject Index 27

Genetic distance Interlocus variation of genetic distance and neutral mutation theory,

2758 Genetic labeling


Genetic polymorphism see also Protein polymorphism Gene dosage: Assignment of erythrocyte acid phosphatase locus to

chromosome 2, 4526 Group-specific component (Gc) proteins bind vitamin D and

25-hydroxyvitamin D, 2076 Language boundaries and biological differentiation on Bougainville:

Multivariate analysis of variance, 2247 Trophic radiation through polymorphism in cichlid fishes, 4669

Genetics, complement Immunochemical characterization of murine H-2 controlled Ss (serum

substance) protein through identification of its human homologue as fourth component of complement, 4536

Genetics, human Tay-Sachs' and Sandhoffs diseases: Assignment of genes for

hexosaminidase A and B to individual human chromosomes, 263 Genetics, mitochondrial


Genetics, population Allozymic and chromosomal similarity in two Drosophila species, 4521 Distribution of allelic frequencies in finite population under stepwise

production of neutral alleles, 2761 Enzyme activity, cell geometry, and fitness in Saccharomyces cerevisiae,

794 General kin selection models for genetic evolution of sib altruism in

diploid and haplodiploid species, 4531 Moments for sum of an arbitrary function of gene frequency along a

stochastic path of gene frequency change, 1602 Statistical analyses of Drosophila and human protein polymorphisms,

3194 Temporal fluctuation of selection coefficient affects gene frequency in a

population, 4541 Genetics, somatic cell

see also Hybrid cell Genetic heterogeneity in xeroderma pigmentosum: Complementation

groups and their relationship to DNA repair rates, 59 Isolation of mammalian cell mutants deficient in glucose-6-phosphate

dehydrogenase activity: Linkage to hypoxanthine phosphoribosyltransferase, 493

Structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells, 5051

Tay-Sachs' and Sandhoff's diseases: Assignment of genes for hexosaminidase A and B to individual human chromosomes, 263

Transfer of human gene for hypoxanthine-guanine phosphoribosyltransferase via isolated human metaphase chromosomes into mouse L-cells, 1792

Genetic variation Genetic variation as a test of natural selection, 2145 Trophic radiation through polymorphism in cichlid fishes, 4669

Gene transfer Evolution of type C viral genes: Preservation of ancestral murine type C

viral sequences in pig cellular DNA, 4090 Gene transfer to human cells: Transducing phage Xplac gene expression

in GMi-gangliosidosis fibroblasts, 3531 Transfer of human gene for hypoxanthine-guanine

phosphoribosyltransferase via isolated human metaphase chromosomes into mouse L-cells, 1792

Geodesics Connectivities Ri of Frechet spaces in variational topology, 2069

Geology Nonprevalence of biochemical fossils in kerogen from pre-Phanerozoic

sediments, 4706 Paleopleurocapsa wopfnerii gen. et sp. nov.: Late Precambrian alga and

its modern counterpart, 2488 Geomorphology, mathematical

Stochastic models for Earth's relief, shape and fractal dimension of coastlines, and number-area rule for islands, 3825

Geophysics Estimates of stratospheric pollution by analytic model, 4711 Gross thermodynamics of heat engines in deep interior Earth, 1555 Theory of homogeneous dynamos in a rotating liquid sphere, 1496

GERL Cytochemical studies of Golgi apparatus, GERL, and lysosomes in

neurons of dorsal root ganglia in mice, 508 Gibberellin

Genetic control of endosperm amylase activity and gibberellic acid responses in standard-height and short-statured wheats, 892

Gibberellic-acid-induced cell elongation in lettuce hypocotyls, 1107 Satellite-rich DNA in cucumber: Hormonal enhancement of synthesis

and subcellular identification, 2260 Globin

see also Hemoglobin; Ribonucleic acid, messenger, globin Globin gene

Hemoglobin synthesis in somatic cell hybrids: Globin gene expression in hybrids between mouse erythroleukemia and human marrow cells or fibroblasts, 1102

Human globin gene expression and linkage in bone marrow and fetal liver, 258

Relative numbers of human globin genes assayed with purified a and /3



28 Subject Index

complementary human DNA, 1550 Rous sarcoma virus activates embryonic globin genes in chicken

fibroblasts, 4464 Strand-selective transcription of globin genes in rabbit erythroid cells

and chromatin, 4835 Globin synthesis

Imbalanced globin chain synthesis in heterozygous /-thalassemic bone marrow, 3853

Nonribosomal proteins associated with eukaryotic native small ribosomal subunits, 3392

Glucagon Hepatic regeneration regulated in rats by synergistic action of insulin

and glucagon, 1157 Immunoreactive somatostatin is present in discrete cells of endocrine

pancreas, 1340 Immunoreactive somatostatin is present in discrete cells of endocrine

pancreas (correction), 2833 Mechanism of action of cholera toxin and mobile receptor theory of

hormone receptor-adenylate cyclase interactions, 33 Role of carnitine in hepatic ketogenesis, 4385 Specific endocrine and hormonal receptor changes associated with liver

regeneration in adult rats, 4033 Glucocorticoid

Circadian rhythm of tyrosine hydroxylase induction by short-term cold stress: Modulatory action of glucocorticoids in newborn and adult rats, 1415

Effect of chemical inactivating agents on glucocorticoid receptor proteins in mouse and hamster cells, 3060

Partial purification of glucocorticoid receptor, 3849 Gluconeogenesis

Hormonal effects on structure and catalytic properties of fructose 1,6-bisphosphatase, 2969

Glucose Diabetes mellitus: Changes in transport properties of isolated intestinal

microvillous membranes, 2027 Interaction of enzyme I of the phosphoenolpyruvate:sugar


Plasmin digests of S-carbamidomethylated human growth hormone, 1684 Glucose-6-phosphate dehydrogenase (EC 1.1.1.49)


Isolation of mammalian cell mutants deficient in glucose-6-phosphate dehydrogenase activity: Linkage to hypoxanthine phosphoribosyltransferase, 493

Glutamate dehydrogenase, NAD-specific (EC 1.4.1.2) Partial amino-acid sequence of NAD-specific glutamate dehydrogenase

of Neurospora crassa, 4891 Glutamine metabolism, regulation


Glutamine synthetase Functional arginyl residues as ATP binding sites of glutamine synthetase

and carbamyl phosphate synthetase, 2616 Glutamine synthetase (EC 6.3.1.2)


Glutamine synthetase forms three- and seven-stranded helical cables, 3402


Glutamyl cyclotransferase Utilization of L-cystine by y-glutamyl transpeptidase-^y-glutamyl

cyclotransferase pathway, 1985 y-Glutamyl transpeptidase

Utilization of L-cystine by -y-glutamyl transpeptidase-^-glutamyl cyclotransferase pathway, 1985

Glutathione Inhibition of protein synthesis in rabbit reticulocyte lysates by

double-stranded RNA and oxidized glutathione: Indirect mode of action on polypeptide chain initiation, 1286

Utilization of L-cystine by y-glutamyl transpeptidase--y-glutamyl cyclotransferase pathway, 1985

Glycine Nuclear magnetic resonance spectroscopy: Reinvestigation of carbon-13

spin-lattice relaxation time measurements of amino acids, 1599 Glycine max

Enhancement of soybean RNA polymerase I by auxin, 69 Enhancement of soybean RNA polymerase I by auxin (correction), 2468 Two responses to auxin separated by cytokinin inhibition, 1822

Glycocalyx Immunological escape mechanism in spontaneously metastasizing

mammary tumors, 1012 Ultrastructural localization of insulin receptors on adipocytes, 3526

Glycogen Inactivation of rabbit muscle phosphorylase phosphatase by cyclic

AMP-dependent kinase, 3004 Glycogen synthase (EC 2.4.1.11)


Glycolysis, oscillating Control of oscillating glycolysis of yeast by stochastic, periodic, and

steady source of substrate: Model and experimental study, 3829 Glycopeptide

Appearance of smaller mannosyl-glycopeptides on surface of a human cell transformed by simian virus 40, 2687



Glycophorin Amino-acid sequence and oligosaccharide attachment sites of human

erythrocyte glycophorin, 2964 Glycoprotein

Chinese hamster ovary cells selected for resistance to cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine-glycoprotein N-acetylglucosaminyltransferase activity, 3323

Extensive homology between subunits of phytohemagglutinin mitogenic proteins derived from Phaseolus vulgaris, 1388


Primary structure of deleted human lambda type immunoglobulin light chain containing carbohydrate: Protein Sm X, 4559

Purification and characterization of retina-specific cell-aggregating factor, 916


Glycosyl transferase ectoenzyme systems Cell-cell interactions: Enhancement of glycosyl transferase ectoenzyme

systems during Chlamydomonas gametic contact, 310 Glyoxal

Interaction of glyoxal and methylglyoxal with biogenic amines, 1610 Golgi apparatus

Cytochemical studies of Golgi apparatus, GERL, and lysosomes in neurons of dorsal root ganglia in mice, 508

Cytochemical study of secretory process in transplantable insulinoma of Syrian golden hamster, 4501

Gonadoliberin Differential sub-cellular compartmentalization of thyrotropin releasing

hormone (TRH) and gonadotropin releasing hormone (LRH) in hypothalamic tissue, 3153

Gonadotropin Physical characteristics of the gonadotropin receptor-hormone

complexes formed in vivo and in vitro, 1272 Gonadotropin releasing hormone

see Gonadoliberin Gossypium barbadense


Gradient sensing Quantitation of sensory response in bacterial chemotaxis, 710

Graft rejection Immunosuppressive effect of syngeneic thymus cells on allograft

rejection, 2371 Grass-bacteria association

Potential for nitrogen fixation in maize genotypes in Brazil, 2389 Grassland ecosystem


Greatest common divisor Analysis of subtractive algorithm for greatest common divisors, 4720

Group selection Group selection, altruism, reinforcement, and throwing in human

evolution, 3748 Theory of group selection, 143

Group-specific component (Gc) Group-specific component (Gc) proteins bind vitamin D and

25-hydroxyvitamin D, 2076 Group theory

Algebraic description of stereochemical correspondence, 2385 Growth band, shell

Slow growth rate of deep-sea clam determined by 228Ra chronology, 2829 Growth, cell

see Cell growth Growth factor

see also Epidermal growth factor; Nerve growth factor Control of ovarian cell growth in culture by serum and pituitary factors,

483 Isolation of cationic polypeptide from human serum that stimulates

proliferation of 3T3 cells, 2635 Growth hormone

see Somatotropin Growth induction

Induction of growth in resting fibroblastic cell cultures by Ca++, 1584 Growth inhibition

Anticytokinin activity of substituted pyrrolo[2,3-d]pyrimidines, 3508 Inhibition of replication of normal adrenocortical cells in culture by

adrenocorticotropin, 113 Melanoma cells resistant to inhibition of growth by melanocyte

stimulating hormone, 951 Sulfhydryl dependence in primary explant hematopoietic cells:

Inhibition of growth in vitro with vitamin B12 compounds, 73 Growth, microbial

Use of adenylate energy charge ratio to measure growth state of natural microbial communities, 2112

Growth regulation Cell cycle studies of mononucleate and cytochalasin-B-induced

binucleate fibroblasts, 869 Central role for magnesium in coordinate control of metabolism and

growth in animal cells, 3551 Cyclic AMP and cyclic GMP concentrations in serum- and

density-restricted fibroblast cultures, 1063 Hepatic regeneration regulated in rats by synergistic action of insulin

and glucagon, 1157 Serum rapidly stimulates ouabain-sensitive s6Rb+ influx in quiescent

3T3 cells, 4492




Growth response General model for nutritional responses of higher organisms, 4327

Growth restricting conditions Aging and its relation to cell growth and differentiation in Drosophila


Growth, tumor Solid tumor models for assessment of different treatment modalities:


Growth, viral Temperature-sensitive cell mutations that inhibit adenovirus 2

replication, 328 GT*C:-loop

Biosynthesis of ribosylthymine in the transfer RNA of Streptococcus faecalis: Folate-dependent methylation not involving S-adenosylmethionine, 528

Guanidine-HCl Molecular weights of adrenocorticotropic hormone in extracts of anterior

and intermediate-posterior lobes of mouse pituitary, 3565 Guanosine 3':5'-cyclic monophosphate

Antigen-stimulated changes in cyclic nucleotide levels in mouse, 2320 Bioregulation of lysosomal enzyme secretion from human neutrophils:


Calcium-binding protein as calcium-dependent regulator of brain adenylate cyclase, 64



Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic GMP in rat liver, intestine, and testis, 2022

Increased particulate and decreased soluble guanylate cyclase activity in regenerating liver, fetal liver, and hepatoma, 1965

Oxygen and cyclic nucleotides in human umbilical artery, 3883 Protein kinase activation as early event in trans-synaptic induction of

tyrosine 3-monooxygenase in adrenal medulla, 1152 Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma

cells, 3472 Guanosine 3'-diphosphate-5'-diphosphate

Effects of guanosine tetraphosphate on cell-free synthesis of Escherichia coli ribosomal RNA and other gene products, 2881

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): Positive effector for histidine operon transcription and general signal for amino-acid deficiency, 4389


Relationship of first step in protein synthesis to ppGpp: Formation of A(5')ppp(5')Gpp, 2653

Guanosine metabolism Guanosine metabolism and regulation of fruiting body construction in

Dictyostelium discoideum, 4479 Guanosine, 7-methyl

5'-Terminal m7G(5')ppp(5')Gmp in vivo: Identification in reovirus genome RNA, 742

Guanosine 5'-triphosphate analog Activation of adenylate cyclase by phosphoramidate and phosphonate


Guanylate cyclase (EC 4.6.1.2) Increased particulate and decreased soluble guanylate cyclase activity in

regenerating liver, fetal liver, and hepatoma, 1965 Guinea pig

Changes in relative levels of guanosine-3':5'-monophosphate-dependent and adenosine-3':5'-monophosphate-dependent protein kinases in lung, heart, and brain of developing guinea pigs, 2256

Changes in ribosomal RNA processing paths in resting and phytohemagglutinin-stimulated guinea pig lymphocytes, 3315

Chemical nature of transfer factor (authors' statement), 409 Guinea pig transfer factor-like activity detected in vitro, 4573 Transfer factor: Subcellular component that transmits information for

specific immune responses (authors' statement), 409

Hadron Pion spectrum in decay of ~'(3.7) to ~(3.1), 4216

Hair dye Hair dyes are mutagenic: Identification of a variety of mutagenic

ingredients, 2423 Haldane coefficient

Interaction of hemoglobin with three ligands: Organic phosphates and Bohr effect, 2465

Hammerstein equation, nonlinear Strongly nonlinear integral equations of Hammerstein type, 1937

Hammett's constant Magnetic circular dichroism of molecules in dense media: Relation

between magnetic circular dichroism and Hammett's constants, 452 Hamster


Hamster cell line, a-amanitine-resistant Hamster a-amanitine-resistant RNA polymerase II able to transcribe

polyoma virus genome in somatic cell hybrids, 753 Haplodiploidy

General kin selection models for genetic evolution of sib altruism in diploid and haplodiploid species, 4531

Subject Index 29

H chain see Immunoglobulin heavy chain

Hearing see also Auditory physiology Amphisbaenian ear: Blanus cinereus and Diplometopon zarudnyi, 1487

Heart Changes in cyclic nucleotide metabolism in aorta and heart of


Fetal mouse hearts: Model for studying ischemia, 2809 Fetal mouse hearts: Model for studying ischemia (correction), 4679 Interaction of ubisemiquinone with a paramagnetic component in heart

tissue, 2886. Mechanism and modification of bradykinin-induced coronary

vasodilation, 2060 Heat engine

Gross thermodynamics of heat engines in deep interior Earth, 1555 Heavy chain disease

Repetitive hinge region sequences in human IgG3: Isolation of an 11,000-dalton fragment, 723

Heisenberg group Necessary and sufficient conditions for solvability of Lewy equation,

3287 Helix unwinding angle

Conformational fluctuations of DNA helix, 4275 Determination of number of superhelical turns in simian virus 40 DNA

by gel electrophoresis, 4876 Hemagglutination


Hematologic disorders Nonrandom chromosomal abnormalities in hematologic disorders of

man, 152 Heme


Ozone model for bonding of 02 to beme in oxyhemoglobin, 2335 Resonance Raman effect in A-oxo-bis[iron(III)tetraphenylporphyrin],

4419 Heme oxygenase

Cobalt induction of hepatic heme oxygenase: Evidence that cytochrome P-450 is not essential for this enzyme activity (correction), 772

Hemerythrin Tertiary structure of myohemerythrin at low resolution, 2160

Hemin Association of cyclic AMP-dependent protein kinase with purified


Hemocyanin Protein-water interaction studied by solvent 1H, 2H, and 170 magnetic

relaxation, 2667 Hemoflagellate


Hemoglobin see also Globin Bis(N-maleimidomethyl) ether: Antisickling reagent, 4153 Hemoglobin interaction in sickle cell fibers: Theoretical approaches to

molecular contacts, 1330 Interaction of hemoglobin with three ligands: Organic phosphates and

Bohr effect, 2465 Magnitude of subunit inequivalence for oxygen release from hemoglobin:

Reinvestigation of oxygen-pulse experiment, 3998 Oxygen and carbon monoxide binding to synthetic analogs of myoglobin

and hemoglobin active sites, 1166 Hemoglobin Aic


Hemoglobin, / chain Hemoglobin Cranston, unstable variant having elongated /3 chain due to

nonhomologous crossover between two normal f/ chain genes, 3609 Hemoglobin Cranston

Hemoglobin Cranston, unstable variant having elongated / chain due to nonhomologous crossover between two normal 3 chain genes, 3609

Nucleotide sequences of 3'-terminal untranslated region of messenger RNA for human beta globin chain, 3614

Hemoglobin H disease Quantitative deficiency of chain-specific globin mRNA in thalassemia

syndromes, 567 Hemoglobin, sickle

Isolation of antibodies specific to sickle hemoglobin by affinity chromatography using a synthetic peptide, 4759

Hemoglobin synthesis Expression of /-thalassemia gene in first trimester fetus, 3633 Hemoglobin synthesis in somatic cell hybrids: Globin gene expression in



Human globin gene analysis for patient with /?/iSf?-thalassemia, 2294 Hemoglobin Tak


Hemopoiesis Formation of bone marrow in fibroblast-transformation ossicles, 2212



30 Subject Index

Hemoprotein synthesis Apocytochrome P-450: Reconstitution of functional cytochrome with

hemin in vitro, 400 Hemostatic defect

Physiological role of an endoperoxide in human platelets: Hemostatic defect due'to platelet cyclo-oxygenase deficiency, 1446

Hemovanadin Nuclear magnetic resonance spectrum of living tunicate blood cells and

structure of native vanadium chromogen, 2217 Heparan sulfate

Mucopolysaccharides associated with nuclei of cultured mammalian cells, 2032

Heparin bound to Sepharose Isolation of rabbit reticulocyte initiation factors by means of heparin

bound to Sepharose, 2352 Hepatic

see also Liver Hepatic necrosis

Experimental alcohol-induced hepatic necrosis: Suppression by propylthiouracil, 1137

Hepatic regeneration Hepatic regeneration regulated in rats by synergistic action of insulin

and glucagon, 1157 Hepatitis

see also Liver Experimental alcohol-induced hepatic necrosis: Suppression by

propylthiouracil, .1137 Lymphocyte cytotoxicity to autologous liver cells in chronic active

hepatitis, 1301 Sequential production of fatty liver, hepatitis, and cirrhosis in

sub-human primates fed ethanol with adequate diets, 437 Hepatitis B virus

Genome of hepatitis B virus: Restriction enzyme cleavage and structure of DNA extracted from Dane particles, 4597

Hepatoma Tumor regression at untreated site during immunotherapy of identical

distant tumor, 3680 Heptose-deficient mutant


Hermite semigroup Inequalities in Fourier analysis on Rn, 638

Herpes simplex virus Anatomy of herpes simplex virus DNA: Strain differences and

heterogeneity in locations of restriction endonuclease cleavage sites, 1768


Possible peptide chain termination mutants in thymidine kinase gene of herpes simplex virus, 4081


Herpesvirus Epstein-Barr virus genomes with properties of circular DNA molecules

in carrier cells, 1477 Herpesvirus saimiri

Lymphocyte cytotoxicity augmented by antibody to herpesvirus saimiri associated antigens, 1671

Heteroduplex mapping Acquisition of determinant for chloramphenicol resistance by coliphage

lambda, 5041 Heterozygosity

Genetic variation as a test of natural selection, 2145 Porphyria variegata and porphyria cutanea tarda in siblings: Chemical

and genetic aspects, 5126 Hexokinase B (EC 2.7.1.1)

Structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution, 38

Hexosaminidase Tay-Sachs' and Sandhoff's diseases: Assignment of genes for

hexosaminidase A and B to individual human chromosomes, 263 (3-Hexyl-2-(3-hexyl-2-benzoxazolinylidene)-l-propenyl)-benzoxazolium

iodide Donnan potential of rabbit skeletal muscle myofibrils: I.

Electrofluorochromometric detection of potential, 1325 High potential iron protein

see Protein, iron-sulfur, high potential Hill equation

Redox equilibria of liganded forms of methemoglobin, 3382 Hill's equation

Well-posed inverse spectral problems, 2496 Hinge region


Histidine see also Operon, histidine

Histidine G enzyme see Adenosine triphosphate phosphoribosyltransferase (EC 2.4.2.17)

Histidine-rich polypeptide On primary structure and biosynthesis of histidine-rich polypeptide from

malarial parasite Plasmodium lophurae, 3057 Histocompatibility

see also Antigen, histocompatibility; Gene, H-2 Activation of T and B lymphocytes in vitro: Presence of /2-microglobulin

determinants on allogeneic effect factor, 4577 H-2 gene complex restricts transfer of delayed-type hypersensitivity in

mice, 5095


Tumor-associated transplantation antigens in immune rejection of mouse malignant cell hybrids, 2130

Tyrosine peptide homologies in the HLA antigen system, 5081 Histocompatibility gene complex

Immunochemical characterization of murine H-2 controlled Ss (serum substance) protein through identification of its human homologue as fourth component of complement, 4536

Thymus-derived rat lymphocyte receptor for cell surface antigens is nonserologically defined product of major histocompatibility gene complex, 1147

Histocompatibility-2 genotype Association of mouse liver adenosine 3':5'-cyclic monophosphate (cyclic

AMP) levels with Histocompatibility-2 genotype, 2644 Immunochemical characterization of murine H-2 controlled Ss (serum

substance) protein through identification of its human homologue as fourth component of complement, 4536

Histogenesis Origin of hemopoietic stem cells in embryonic bursa of Fabricius and


bone marrow studied through interspecific chimeras (correction), 5164 Histone

see also Chromatin Absence of histone Fl in mitotically dividing, genetically inactive

nucleus, 2672 Chemical and physical properties of fractionated chromatin, 3328 Chromatin architecture: Investigation of subunit of chromatin by dark

field electron microscopy, 2691 Deposition of histones onto replicating chromosomes, 4440 Discrete subunits released after nuclease and trypsin digestion of

chromatin, 1212 Gene expression in mouse neuroblastoma cells: Properties of the genome,

3119 Histone gene arrangement in sea urchin Strongylocentrotus purpuratus,

4815 Histone-histone propinquity by aldehyde fixation of chromatin, 1304 Interaction of fl histone with superhelical DNA, 2597 Location of histones on simian virus 40 DNA, 2895 Natural occurrence of poly(ADP-ribosyl) histones in rat liver, 205 New histones found in mature mammalian testes, 2714 Octamer of histones in chromatin and free in solution, 2626 Preferential and cooperative binding of histone I to chromosomal

mammalian DNA, 733 Selective effects of inhibitors of protein synthesis on metabolism of

nuclear and cytoplasmic proteins: Coordinate synthesis of nonhistone chromosomal proteins, 4450

Subunit structure of naturally occurring chromatin lacking histones Fl and F3, 3536

H2L2, covalent assembly Reoxidation of interchain disulfide bonds in human immunoglobulin

IgGlK: Sulfhydryl disappearance and intermediates in covalent assembly of H2L2, 353

Hodge structure Complexifications of real manifolds, 4210

Hodgkin's disease see also Lymphoma Concanavalin A receptors on surface membrane of lymphocytes from

patients with Hodgkin's disease and other malignant lymphomas, 1046 Membrane differences in peripheral blood lymphocytes from patients

with chronic lymphocytic leukemia and Hodgkin's disease, 2428 Holomorphic convexity


Holomorphic discrete series Characters of holomorphic discrete series, 3275

Holomorphic function Necessary and sufficient conditions for solvability of Lewy equation,

3287 Hominid


Homocitrate synthase (EC 4.1.3.21) Reversible, coenzyme-A-mediated inactivation of biosynthetic

condensing enzymes in yeast: Regulatory mechanism, 1802 Homocystinuria


Homoserine dehydrogenase (EC 1.1.1.3) Evolution of biosynthetic pathways: Immunological approach, 1268

Homoserine kinase (EC 2.7.1.39) Evolution of biosynthetic pathways: Immunological approach, 1268

Hope National Science Foundation: Origins, hopes, and aspirations

(Symposium), 2839 Hordeum vulgare

Biosynthesis of 1-aminolevulinic acid from intact carbon skeleton of glutamic acid in greening barley, 2719

Evolutionary changes in mating system of experimental population of barley (Hordeum vulgare L.), 943

Hormone, insect Aging and its relation to cell growth and differentiation in Drosophila



Ovary as a source of n-ecdysone in an adult mosquito, 3255




Hormone, mammalian see also specific hormones; receptor entries; Steroid Activation of adenylate cyclase by phosphoramidate and phosphonate


Association of mouse liver adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels with Histocompatibility-2 genotype, 2644

Contribution of peptide backbone to the action of oxytocin analogs, 563 Control of mRNA for hepatic tryptophan oxygenase during hormonal

and substrate induction, 1017 Estrogen affects gene expression in chick oviduct: Nuclear receptor levels

and initiation of transcription, 4228 Functional level of rat liver tryptophan 2,3-dioxygenase messenger RNA

during superinduction of enzyme with actinomycin D, 4285 Human synoviocytes: Activation and desensitization by prostaglandins

and l-epinephrine, 3124 Mechanism of action of cholera toxin and mobile receptor theory of

hormone receptor-adenylate cyclase interactions, 33 Nature of increase in renal ornithine decarboxylase activity after

cycloheximide administration in rat, 2279 Neurohypophyseal hormones, analogs, and fragments: Their effect on

puromycin-induced amnesia, 4180 Nuclear receptors for thyroid hormone: Nonrandom distribution within

chromatin, 1787 Significance of retention of ligand by protein, 2120 Specific endocrine and hormonal receptor changes associated with liver

regeneration in adult rats, 4033 Hormone, plant

see also Auxin; Gibberellin Satellite-rich DNA in cucumber: Hormonal enhancement of synthesis

and subcellular identification, 2260 Host range, viral

Mapping of biological functions on RNA of avian tumor viruses: Location of regions required for transformation and determination of host range, 4772


Hubble law Phenomenological analysis of observed relations for low-redshift galaxies,

4691 Hunger

Control of meal size by central noradrenergic action, 3740 Hybrid cell

see also Genetics, somatic cell Biochemical lesions used for selection of human cells with hybrid

cytoplasms, 1812 Gene(s) for cell transformation assigned to human chromosome 7

carrying simian virus 40 genome, 1658 Genetic analysis of cell surface: Association of human chromosome 5


Genetic complementation in heterokaryons of human fibroblasts defective in cobalamin metabolism, 3181

Hamster a-amanitine-resistant RNA polymerase II able to transcribe polyoma virus genome in somatic cell hybrids, 753

Hemoglobin synthesis in somatic cell hybrids: Globin gene expression in hybrids between mouse erythroleukemia and human marrow cells or fibroblasts, 1102





Morphine receptors as regulators of adenylate cyclase activity, 590 Neuronal properties of hybrid neuroblastoma X sympathetic ganglion

cells, 4923 Presence of human chromosome 7 carrying simian virus 40 genome in

cells of tumors induced by hybrid somatic cells, 1397 Somatic hybrid of thymus leukemia (+) and (-) cells forms thymus

leukemia antigens but fails to undergo modulation, 1873 Tumor-associated transplantation antigens in immune rejection of mouse

malignant cell hybrids, 2130 Hybrid nuclease (EC 3.1.4.34)

Electrophoretic patterns of deadenylylated chorion and globin mRNAs, 2959

Hybrid plasmid, construction of Biochemical construction and selection of hybrid plasmids containing

specific segments of Escherichia coli genome, 4361 Hybrid sterility


Hydrocortisone Control of mRNA for hepatic tryptophan oxygenase during hormonal

and substrate induction, 1017 Functional level of rat liver tryptophan 2,3-dioxygenase messenger RNA

during superinduction of enzyme with actinomycin D, 4285 Hydrodynamic model

Possibility of a hydrodynamic model of the electron, 2037 Hydrodynamics

Motion of a slightly compressible fluid, 539 Hydrogenase


Subject Index 31

Hydrogen bond Hydrogen bonding in yeast phenylalanine transfer RNA, 4866 Model for hydrogen bond, 4701 NH...S Hydrogen bonds in Peptococcus aerogenes ferredoxin,

Clostridium pasteurianum rubredoxin, and Chromatium high potential ironr protein, 4854

Tertiary hydrogen bonds in solution structure of transfer RNA, 2049 Hydrogen ion concentration

see pH; Proton gradient Hydrogen peroxide, decomposition of

Decomposition of hydrogen peroxide catalyzed by ferric ethylenediaminetetraacetate complex, 140

Hydrogen production Photoassisted electrolysis of water by irradiation of a titanium dioxide

electrode, 1518 Hydrostatic pressure effects on enzymes


Hydroxide Reaction of tris(bipyridine)ruthenium(III) with hydroxide and its

application in a solar energy storage system, 2858 Hydroxyapatite

Nucleic acid reassociation kinetics: Reactivity of single-stranded tails in DNA-DNA renaturation, 4805

2-Hydroxyethanethiolato(2,2',2"-terpyridine)platinum(II) X-ray fiber diffraction evidence for neighbor exclusion binding of

platinum metallointercalation reagent to DNA, 4825 Hydroxylase


Hydroxymethylglutaryl coenzyme A reductase (EC 1.1.1.34) Sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated

mouse lymphocytes, 1950 Hydroxysteroid dehydrogenase

Steroidogenesis in rabbit preimplantation embryos, 298 Hymenoptera

see also Lasioglossum zephyrum General kin selection models for genetic evolution of sib altruism in

diploid and haplodiploid species, 4531 Hypercholesterolemia, familial

Genetic heterogeneity in familial hypercholesterolemia: Two different mutations affecting functions of low-density lipoprotein receptor, 1092

Receptor-dependent hydrolysis of cholesterol esters contained in plasma low density lipoprotein, 2925

Hyperglycemia Synthesis of hemoglobin Aic in normal and diabetic mice: Potential

model of basement membrane thickening, 3687 Hyperlipidemia


Hypersensitivity, delayed-type H-2 gene complex restricts transfer of delayed-type hypersensitivity in

mice, 5095 Inhibition by interferon of delayed-type hypersensitivity in mouse, 1753

Hypersurface On equimultiple subvarieties of algebroid hypersurfaces, 1425 On equimultiple subvarieties of algebroid hypersurfaces (correction),

3260 Pseudoconformal geometry of hypersurfaces in Cn+l, 2433

Hypertension, neurogenic Changes in cyclic nucleotide metabolism in aorta and heart of


Hypervariable region Diversity of light chain variable region sequences among rabbit

antibodies elicited by the same antigens, 2180 Similarities among hypervariable segments of immunoglobulin chains,

5107 Hypocotyl

Gibberellic-acid-induced cell elongation in lettuce hypocotyls, 1107 Two responses to auxin separated by cytokinin inhibition, 1822

Hypogeusia Zinc protein isolated from human parotid saliva, 488

Hypophyseal factor Influence of novel hypophyseal factor on steroid metabolism in cultured

hepatoma cells, 4986 Hypopituitary serum

Enhancement of somatomedin titers of normal and hypopituitary sera by addition of L-triiodothyronine in vitro at physiological concentrations, 604

Hypothalamus Androgen- and estrogen-binding macromolecules in developing mouse

brain: Biochemical and genetic evidence, 4303 Control of meal size by central noradrenergic action, 3740 Differential sub-cellular compartmentalization of thyrotropin releasing


Effect of hypothalamic deafferentation on thyrotropin-releasing hormone levels in rat brain, 4177

Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) Human gene expression in rodent cells after uptake of isolated

metaphase chromosomes, 1797 Human X-linked genes regionally mapped utilizing X-autosome

translocations and somatic cell hybrids, 2125 Hypoxanthine phosphoribosyltransferase deficiency: Association of




32 Subject Index

Isolation of mammalian cell mutants deficient in glucose-6-phosphate dehydrogenase activity: Linkage to hypoxanthine phosphoribosyltransferase, 493



Transfer of human gene for hypoxanthine-guanine phosphoribosyltransferase via isolated human metaphase chromosomes into mouse L-cells, 1792

Hypoxia Experimental alcohol-induced hepatic necrosis: Suppression by

propylthiouracil, 1137 Fetal mouse hearts: Model for studying ischemia, 2809 Fetal mouse hearts: Model for studying ischemia (correction), 4679

Imaginal disc Aging and its relation to cell growth and differentiation in Drosophila



Immune complex Induction of immune response through interaction of helper cells with

immune complex bound to surface of B cells, 4555 New complement function: Solubilization of antigen-antibody

aggregates, 418 Immune rejection

Tumor-associated transplantation antigens in immune rejection of mouse malignant cell hybrids, 2130

Immune response Chemical nature of transfer factor (authors' statement), 409 Complementation of H-2-linked Ir genes in mouse, 3671 Cyclic AMP and immune responses: Changes in splenic level of cyclic

AMP during response of mice to antigen, 888 Induction of immune response through interaction of helper cells with

immune complex bound to surface of B cells, 4555 Transfer factor: Subcellular component that transmits information for

specific immune responses (authors' statement), 409 Immune surveillance

see also Antigen, tumor; Tumor immunology Functional interactions of viral and histocompatibility antigens at tumor

cell surfaces, 5066 Lysis of leukemia cells by spleen cells of normal mice, 2780 Subversion of immune system by tumor cells and role of prostaglandins,

1848 Immunity, cell-mediated

Biologic and antigenic similarity of virus-induced migration inhibition factor to conventional, lymphocyte-derived migration inhibition factor, 1.641

H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice, 5095

Lymphokine-induced production and release of lysosomal enzymes by macrophages, 2091

Immunity, natural Lysis of leukemia cells by spleen cells of normal mice, 2780

Immunoadjuvant Comparison between macrophage activation and enhancement of

nonspecific resistance to tumors by mycobacterial immunoadjuvants, 4105

Enhancement of immunity against murine syngeneic tumors by fraction extracted from non-pathogenic mycobacteria, 3656

Immunoadsorbent Evolution of biosynthetic pathways: Immunological approach, 1268

Immunochemistry Pituitary growth hormones: Evolutionary conservatism based on

immunochemical studies, 4322 Immunocytochemistry


Immunodeficiency Leukocyte migration inhibitory factor (LMIF) induced by concanavalin

A: Standardized microassay for production in vitro, 3197 Protection of lethally irradiated mice with allogeneic fetal liver cells:

Influence of irradiation dose on immunologic reconstitution, 4100 Immunoelectrophoresis, crossed

Factor-VIII-related antigen: Multiple molecular forms in human plasma, 5121

Synthesis and differentiation of plasma proteins in cultured embryonic chicken liver cells: System for study of regulation of protein synthesis, 5007

Immunofluorescence Antibody against tubulin: Specific visualization of cytoplasmic

microtubules in tissue culture cells, 459 Cytoplasmic microtubules in normal and transformed cells in culture:

Analysis by tubulin antibody immunofluorescence, 4981 Distribution and virogenic effects of 5-bromodeoxyuridine in

synchronized rat embryo cells, 1829 Filamin, a new high-molecular-weight protein found in smooth muscle

and non-muscle cells, 4483 Organization of actin and myosin in normal and transformed cultured

cells, 994 Immunogenetics

Complementation of H-2-linked Ir genes in mouse, 3671


Immunogenicity Stimulation and inhibition of anti-hapten responses in guinea pigs

immunized with hybrid liposomes, 4582 Immunoglobulin

see also Antibody; Myeloma protein; Ribonucleic acid, messenger, immunoglobulin

Antibodies reactive with cell surface carbohydrates, 1127 Evolutionary relationship between immunoglobulins and transplantation

antigens, 1612 Immunochemical evidence for common variable region in three

immunoglobulin classes in the same individual, 4115 Structure and function of immunoglobulin domains: Studies with

beta2-microglobulin on role of intrachain disulfide bond, 548 Immunoglobulin G

Localization of IgG effector site for monocyte receptors, 2081 Removal of senescent cells by human macrophages in situ, 3521 Reoxidation of interchain disulfide bonds in human immunoglobulin

IgGIK: Sulfhydryl disappearance and intermediates in covalent assembly of H2L2, 353


Immunoglobulin genetics Primary structure of deleted human lambda type immunoglobulin light

chain containing carbohydrate: Protein Sm X, 4559 Region of immunoglobulin light-chain mRNA transcribed into


Immunoglobulin heavy chain Authors' statement on the isolation of mRNA coding for immunoglobulin

heavy chain (correction), 4679 Variants of a mouse myeloma cell line that synthesize immunoglobulin

heavy chains having an altered serotype, 1427 Immunoglobulin idiotype

Idiotype positive T cells visualized by autoradiography and electron microscopy, 3210

Immunochemical evidence for common variable region in three immunoglobulin classes in the same individual, 4115

Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes, 2357

Immunoglobulin light chain Bovine factor Xi (Stuart factor): Primary structure of light chain, 16 Cell-free translation of immunoglobulin messenger RNA from

MOPC-315 plasmacytoma and MOPC-315 NR, variant synthesizing only light chain, 224

Evolutionary and structural influences on light chain constant region of human and mouse immunoglobulins, 2785


Immunoglobulin M Activation of antibody Fc function by antigen-induced conformational

changes, 5111 Immunoglobulin structure

Diversity of light chain variable region sequences among rabbit antibodies elicited by the same antigens, 2180

Evolutionary and structural influences on light chain constant region of human and mouse immunoglobulins, 2785


Similarities among hypervariable segments of immunoglobulin chains, 5107

Structure and regulation of immunoglobulins: Kappa allotypes in rat have multiple amino-acid differences in constant region, 5046

Variability of three-dimensional structure in immunoglobulins, 819 Immunoglobulin subgroup

Region of immunoglobulin light-chain mRNA transcribed into complementary DNA by RNA-dependent DNA polymerase of avian myeloblastosis virus, 2511

Immunoglobulin synthesis Cell-free translation of immunoglobulin messenger RNA from


Immunoglobulin variable region Diversity of light chain variable region sequences among rabbit

antibodies elicited by the same antigens, 2180 Immunochemical evidence for common variable region in three

immunoglobulin classes in the same individual, 4115 Region of immunoglobulin light-chain mRNA transcribed into


Immunohistochemical localization Immunohistochemical localization of 3':5'-cyclic AMP and 3':5'-cyclic

GMP in rat liver, intestine, and testis, 2022 Immunohistochemistry, peroxidase-antiperoxidase

Ultrastructural localization of tyrosine hydroxylase in noradrenergic neurons of brain, 659

Immunological escape mechanism Immunological escape mechanism in spontaneously metastasizing

mammary tumors, 1012 Immunological information transfer

Chemical nature of transfer factor (authors' statement), 409 Transfer factor: Subcellular component that transmits information for

specific immune responses (authors' statement), 409 Immunological specificity

Structural features of double-stranded polyribonucleotides required for immunological specificity and interferon induction, 4564

Immunologic reaction Daily periodicity in the activity of a slide used to perform immunologic

reactions at a liquid-solid interface, 2462




Immunologic reconstitution Protection of lethally irradiated mice with allogeneic fetal liver cells:

Influence of irradiation dose on immunologic reconstitution, 4100 Immunoprecipitation

Translation of RNA that contains polyadenylate from yeast mitochondria in Escherichia coli ribosomal system, 4293

Immunosuppression Immunosuppressive effect of syngeneic thymus cells on allograft

rejection, 2371 Subversion of immune system by tumor cells and role of prostaglandins,

1848 Immunosurgery

Immunosurgery of mouse blastocyst, 5099 Immunotherapy

Subversion of immune system by tumor cells and role of prostaglandins, 1848

Tumor regression at untreated site during immunotherapy of identical distant tumor, 3680

Impulse conduction Impulse conduction along central axons, 5156

Inbreeding Social structuring of mammalian populations and rate of chromosomal

evolution, 5061 Indomethacin

Mechanism and modification of bradykinin-induced coronary vasodilation, 2060

Induction, chemical Chemical induction of sperm abnormalities in mice, 4425

Induction, neural Repair of ultraviolet irradiation damage to cytoplasmic component

required for neural induction in amphibian egg, 1235 Induction, trans-synaptic


Infectious mononucleosis Cytotoxic effector cells specific for B cell lines transformed by

Epstein-Barr virus are present in patients with infectious mononucleosis, 1622

Infinitesimal generator Infinitesimal generators and quasi-units in potential theory, 2498

Influenza virus hemagglutinin Primary structure of influenza virus hemagglutinin, 93

Information, prior Partial knowledge, entropy, and estimation, 3819

Inheritability Inheritability of plasmids and population dynamics of cultured cells,

4085 Initiation factor

see also Polypeptide chain initiation; Protein synthesis Cytoplasmic control of nuclear DNA synthesis during early development

of Xenopus laevis: Cell-free assay, 2437 Dissociation of ribosomes of Escherichia coli by initiation factor IF-3,

4238 Inhibition of protein synthesis in rabbit reticulocyte lysates by


Interaction of poly(A) and mRNA with eukaryotic initiator Met-tRNAf binding factor: Activity on reticulocyte ribonucleic acid protein particles, 1021



Non-specific stimulation of cell-free protein synthesis by a dialyzable factor isolated from reticulocyte initiation factors ("iRNA"), 714


Initiation of protein synthesis see Polypeptide chain initiation; Protein synthesis, initiation

Inositol locus Induction by RNA of inositol independence in Neurospora crassa, 642

Insect see also Acheta; Aedes; Culiseta; Dacus; Drosophila; Lasioglossum

Insect, odor difference Individual odor differences and their social functions in insects, 2824

Insertion compounds Insertion compounds of 2H-TaS2.NH3, 464

Insulin Cellular levels of feedback regulator of adenylate cyclase and effect of

epinephrine and insulin, 4739 Hepatic regeneration regulated in rats by synergistic action of insulin

and glucagon, 1157 Immunoreactive somatostatin is present in discrete cells of endocrine


pancreas (correction), 2833 Initiation of cell proliferation in cultured mouse fibroblasts by

prostaglandin F2, 2724 Role of carnitine in hepatic ketogenesis, 4385 Specific endocrine and hormonal receptor changes associated with liver

regeneration in adult rats, 4033 Translation of messenger ribonucleic acid from isolated pancreatic islets

and human insulinomas, 4777 Ultrastructural localization of insulin receptors on adipocytes, 3526

Insulin action Sepharose-insulin as tool for study of insulin action, 248

Insulin-binding cell Monocytes rather than lymphocytes are the insulin-binding cells in

Subject Index 33

preparations of human peripheral blood mononuclear leukocytes: Implications for studies of insulin-resistant states in man, 474

Insulin-like activity Isolation of cationic polypeptide from human serum that stimulates

proliferation of 3T3 cells, 2635 Insulinoma


Insulin-resistant state Monocytes rather than lymphocytes are the insulin-binding cells in


Insulin-Sepharose Sepharose-insulin as tool for study of insulin action, 248 Structure of soluble super-active insulin revealed by complex between

cyanogen-bromide-activated Sepharose and amines, 1055 Insulin, super-active

Structure of soluble super-active insulin revealed by complex between cyanogen-bromide-activated Sepharose and amines, 1055

Integrable system, completely Complete solution of periodic Toda problem, 2879

Intercalation see also Deoxyribonucleic acid, intercalation Insertion compounds of 2H-TaS2-NH3, 464

Interface, liquid-solid Daily periodicity in the activity of a slide used to perform immunologic

reactions at a liquid-solid interface, 2462 Interferon

Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system, 3975

Cell-free synthesis of human interferon, 3898 Chromosomal localization of human genes governing interferon-induced

antiviral state, 3129 Early effect of interferon on mouse leukemia cells cultivated in

chemostat, 2265 Inhibition by interferon of delayed-type hypersensitivity in mouse, 1753 Interferon action: II. Membrane-bound alkaline ribonuclease activity in

chick embryo cells manifesting interferon-mediated interference, 182 Interferon activity produced by translation of human interferon

messenger RNA in cell-free ribosomal systems and in Xenopus oocytes, 4881

Multiple active sites on human interferons, 4587 Structural features of double-stranded polyribonucleotides required for

immunological specificity and interferon induction, 4564 Two antigenically distinct species of human interferon, 2185

Intuitionism Disjunction property implies numerical existence property, 2877

A-Invariance General almost automorphy, 3815

Inverse scattering problem On some periodic Toda lattices, 1627

Invertebrate, coral reef Allelopathy and spatial competition among coral reef invertebrates, 5160

Ion channel Interaction of lymphocytes with lipid bilayer membranes: Model for

lymphocyte-mediated lysis of target cells, 2789 Titration of sodium channels in canine gastric mucosa, 3731

Ion flux Acetylcholine-receptor-mediated ion flux in electroplax membrane

preparations, 4371 Components of 02-uptake by excised frog nerve dependent upon

externally supplied sodium ions, 3988 Ion migration

Spectator-ion effect on passage of ions through membranes, 683 lonophore

Contraction of isolated smooth muscle cells by ionophore A23187, 4459 Cooperative activation of action potential Na+ ionophore by neurotoxins,


(correction), 3260 Diabetes mellitus: Changes in transport properties of isolated intestinal

microvillous membranes, 2027 Paired moving charge model of energy coupling: III. Intrinsic ionophores

in energy coupling systems, 896 Ion transport


Paired moving charge model of energy coupling: III. Intrinsic ionophores in energy coupling systems, 896

Spike-forming model of neural membrane, 3468 Iron

see also Ferrate; Ferric Iron protein

see Protein, iron-sulfur, high potential Iron-sulfur cluster

Acid-base properties, hydrolytic mechanism, and susceptibility to O2 oxidation of Fe4S4(SR)4-2 clusters, 231


Iron-sulfur clusters: Ligand exchange kinetics studied on water-soluble Fe4S4(SR)4n- cluster, 2478

Iron-sulfur distance Determination of iron-sulfur distances in rubredoxin by x-ray absorption

spectroscopy, 4003 Irradiation

DNA strand breaks measured within 100 milliseconds of irradiation of Escherichia coli by 4 MeV electrons, 167

Enzymatic induction of DNA double-strand breaks in y-irradiated



34 Subject Index

Escherichia coli K-12, 4265 Ischemia

Fetal mouse hearts: Model for studying ischemia, 2809 Fetal mouse-hearts: Model for studying ischemia (correction), 4679

Island, number-area rule Stochastic models for Earth's relief, shape and fractal dimension of

coastlines, and number-area rule for islands, 3825 Islation

Adiabatic evolution of plasma equilibrium, 3789 Isoelectric point of protein,


Isoenzyme Crystal structure of human erythrocyte carbonic anhydrase B:

Three-dimensional structure at nominal 2.2-A resolution, 51 2-Isopropylmalate synthase (EC 4.1.3.12)


Isoproterenol Catecholamine-induced subsensitivity of adenylate cyclase associated

with loss of /-adrenergic receptor binding sites, 1945 Lack of detectable change in cyclic AMP during cardiac inotropic

response to isoproterenol immobilized on glass beads, 824 Regulation of sensitivity to /-adrenergic stimulation in induction of

pineal N-acetyltransferase, 1661 Isorhodopsin

Isorhodopsin: II. Artificial photosensitive pigment formed from 9,13-dicis retinal, 1538

Isotope kinetics Cholesterol synthesis in man measured by isotope kinetics of squalene,

4612 Isourea, N-substituted

Structure of soluble super-active insulin revealed by complex between cyanogen-bromide-activated Sepharose and amines, 1055

Isozyme see Isoenzyme

Jahn-Teller effect Concerning Jahn-Teller effects, 2104

Ks(Z) Homology of congruence subgroups and K3(Z), 651

Kanamycin resistance Transposition of R factor genes to bacteriophage X, 3628

Karyotype analysis Periodate and concanavalin A induce blast transformation of rat

lymphocytes by indirect mechanism, 3590 Kerogen


Ketogenesis Role of carnitine in hepatic ketogenesis, 4385

Kidney Role of epithelial architecture and intracellular metabolism in proline

uptake and transtubular reclamation in PRO/Re mouse kidney, 1431 Killing, selective

Selective killing of transformed baby hamster kidney (BHK) cells, 4994 Kinetic diagram, biochemical

Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams, 1291

Kinetic mechanism Molecular orbital studies of enzyme activity: Charge relay system and

tetrahedral intermediate in acylation of serine proteinases, 2606 Oxygen exchange in y-phosphoryl group of protein-bound ATP during

Mg2+-dependent adenosine triphosphatase activity of myosin, 2592 Kinetics

Absence of interference in photoexcitation of triplets, 4203 Cholesterol synthesis in man measured by isotope kinetics of squalene,

4612 General model for nutritional responses of higher organisms, 4327 Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase

A: Monitor of multiple conformational states in solution, 4356 Iron-sulfur clusters: Ligand exchange kinetics studied on water-soluble

Fe4S4(SR)4n- cluster, 2478 Kinetics of action of pepsin on fluorescent peptide substrates, 3424 Nucleic acid reassociation kinetics: Reactivity of single-stranded tails in

DNA-DNA renaturation, 4805 Kinetic system

Matrix method for fluctuations and noise in kinetic systems, 3807 Kinetochore

Assembly of microtubules onto kinetochores of isolated mitotic chromosomes of HeLa cells, 4023

Kin selection model General kin selection models for genetic evolution of sib altruism in

diploid and haplodiploid species, 4531 Klebsiella pneumoniae

see also Aerobacter aerogenes Sulfonamide resistance mechanism in Escherichia coli: R plasmids can

determine sulfonamide-resistant dihydropteroate synthases, 2621 Kleinschmidt technique

Analysis of oncornavirus RNA subunits by electron microscopy, 3716 Knowledge, partial

Partial knowledge, entropy, and estimation, 3819 Kodaira embedding

Complexifications of real manifolds, 4210


Lp space Spectra of convolution operators on Lp spaces, 3285

Lactose see Gene, lac; Operon, lactose

Lactuca sativa Gibberellic-acid-induced cell elongation in lettuce hypocotyls, 1107

Lagrange multiplier method Lagrange multiplier method for convex programs, 1778

Lamina Nuclear pore complexes associated with a lamina, 1007

Language boundary Language boundaries and biological differentiation on Bougainville:

Multivariate analysis of variance, 2247 Laplace equation


Lasioglossum zephyrum Individual odor differences and their social functions in insects, 2824

Lateral hypothalamic syndrome Somnolence, akinesia, and sensory activation of motivated behavior in

lateral hypothalamic syndrome, 2819 L chain

see Immunoglobulin light chain Lecithin bilayer

Neutron diffraction studies on location of water in lecithin bilayer model membranes, 376

Lectin see also Concanavalin A; Phytohemagglutinin Cell surface species-specific high affinity receptors for discoidin:

Developmental regulation in Dictyostelium discoideum, 3541 Local anesthetics affect transmembrane cytoskeletal control of mobility

and distribution of cell surface receptors, 4430 Modulation of lymphocyte mitogenesis, 1917

Lectin-resistant cell mutant Chinese hamster ovary cells selected for resistance to cytotoxicity of

phytohemagglutinin are deficient in a UDP -N- acetylglucosamine-glycoprotein N-acetylglucosaminyltransferase activity, 3323

Leray-Schauder principle Strongly nonlinear integral equations of Hammerstein type, 1937

Lesch-Nyhan syndrome Hypoxanthine phosphoribosyltransferase deficiency: Association of



Lettuce see Lactuca sativa

Leucine see Operon, leucine

Leucyl,phenylalanyl-transfer ribonucleic acid-protein transferase (EC 2.3.2.6)

Regulation of proline catabolism by leucyl,phenylalanyl-tRNA-protein transferase, 405

Leucyl-transfer-ribonucleic-acid synthetase (EC 6.1.1.4) Role of leucyl-tRNA synthetase in regulation of branched-chain

amino-acid transport, 3921 Leukemia, human

Growth and differentiation in culture of leukemic leukocytes from patient with acute myelogenous leukemia and re-identification of type-C virus, 4137



Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis, 2804

Purification of RNA-instructed DNA polymerase from human leukemic spleens, 4133



Somatic rearrangement of chromosome 14 in human lymphocytes, 2071 Viral-related information in oncornavirus-like particles isolated from


Leukemia, murine Enhancement of immunity against murine syngeneic tumors by fraction

extracted from non-pathogenic mycobacteria, 3656 Induction of erythroid differentiation in murine virus infected

erythroleukemia cells by highly polar compounds, 1003 Lysis of leukemia cells by spleen cells of normal mice, 2780 Sulfhydryl dependence in primary explant hematopoietic cells:

Inhibition of growth in vitro with vitamin B12 compounds, 73 Trisomy of chromosome 15 in spontaneous leukemia of AKR mice, 1515

Leukemia virus, feline p60 Polypeptide in feline leukemia virus pseudotype of Moloney sarcoma

virus with murine leukemia virus p30 antigenic determinants, 2380 Leukemia virus, Friend

see also Leukemia virus, murine Distribution and virogenic effects of 5-bromodeoxyuridine in

synchronized rat embryo cells, 1829 Erythroid colony induction without erythropoietin by Friend leukemia

virus in vitro, 3556




Erythroid differentiation induced by dimethylsulfoxide in cells infected with Friend virus: Relationship to cell cycle, 28

Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus, 1863


Leukemia virus, gibbon RNA-directed DNA polymerase from human leukemic blood cells and

from primate type-C virus-producing cells: High- and low-molecular-weight forms with variant biochemical and immunological properties, 1194

Leukemia virus, murine see also Leukemia virus, Friend Infection of preimplantation mouse embryos and of newborn mice with

leukemia virus: Tissue distribution of viral DNA and RNA and leukemogenesis in adult animal, 4008

Infectious viral DNA of murine leukemia virus, 4910 In vitro infection of lymphoid cells by thymotropic radiation leukemia

virus grown in vitro, 3546 Murine C-type virus inducing locus Akv-1 is viral genetic material, 906 Murine leukemia virus: Detection of unintegrated double-stranded DNA

forms of the provirus, 447 p60 Polypeptide in feline leukemia virus pseudotype of Moloney sarcoma

virus with murine leukemia virus p30 antigenic determinants, 2380 Transformation of lymphoid cells in vitro by Abelson murine leukemia

virus, 1932 Viral RNA of murine leukemia virus after infection, 343

Leukemogenesis Infection of preimplantation mouse embryos and of newborn mice with


Leukocyte see also Neutrophil Monocytes rather than lymphocytes are the insulin-binding cells in


N-Formylmethionyl peptides as chemoattractants for leucocytes, 1059 Leukocyte migration inhibitory factor


Lewy equation, solvability Necessary and sufficient conditions for solvability of Lewy equation,

3287 Lie algebras, infinite dimensional

Dedekind's q-function and cohomology of infinite dimensional Lie algebras, 2493

Lie group Characters of holomorphic discrete series, 3275 Singular integrals and the principal series, IV, 2459 Theorem on the Schwartz space of a reductive Lie group, 4718

Lifespan, maximum Evolution of human longevity and genetic complexity governing aging

rate, 4664 Ligand

Effect of rotation on the diffusion-controlled rate of ligand-protein association, 4918

Group of thermodynamic potentials applicable to ligand binding by a polyfunctional macromolecule, 1464

Iron-sulfur clusters: Ligand exchange kinetics studied on water-soluble Fe4S4(SR)4n- cluster, 2478

Resonance Raman spectroscopic studies of interactions between trypsin and competitive inhibitor, 4223

Significance of retention of ligand by protein, 2120 Light scattering


Lignin biodegradation Preparation and microbial decomposition of synthetic [14C]lignins, 2515

Lilium longiflorum Presynaptic events in meiocytes of Lilium longiflorum and relation to

crossing-over: A preselection hypothesis, 961 Linear homogeneous recursion

Limits of zeroes of recursively defined polynomials, 4209 Linear transport process

X and Y operators for general linear transport processes, 1210 Linkage disequilibrium

Linkage disequilibrium over space and time in natural populations of Drosophila montana, 4095

Lip, dorsal Repair of ultraviolet irradiation damage to cytoplasmic component

required for neural induction in amphibian egg, 1235 Lipid

see also Membrane; Phospholipid Antagonistic effect of an inhalation anesthetic and high pressure on



Biogenesis of membrane lipids: Mutants of Escherichia coli with temperature-sensitive phosphatidylserine decarboxylase, 1112

Conjugated polyene fatty acids as membrane probes, 1649 Fluorescence polarization and viscosities of membrane lipids of 3T3 cells,

3351 Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by

concanavalin A, 4409 Headgroup conformation and lipid-cholesterol association in

phosphatidylcholine vesicles: 2P. 1H} nuclear Overhauser effect, 3477

Subject Index 35

Isolation of Escherichia coli mutants defective in enzymes of membrane lipid synthesis, 2274

Magnetic resonance spectra of membranes, 1451 Tay-Sachs' and Sandhoffs diseases: Assignment of genes for

hexosaminidase A and B to individual human chromosomes, 263 Theory of the chain melting phase transition of aqueous phospholipid

dispersions, 3993 Lipid-protein interaction

Apoprotein stability and lipid-protein interactions in human plasma high density lipoproteins, 4940



Conjugated polyene fatty acids as membrane probes, 1649 Spin-labeled long chain acylcholine interacts with cholinergic acceptor

protein in membrane environment, 1087 Lipopolysaccharide


Induction of endogenous murine C,type virus in spleen cell cultures treated with mitogens and 5-bromo-2'-deoxyuridine, 535

Lipoprotein Apoprotein stability and lipid-protein interactions in human plasma

high density lipoproteins, 4940 Genetic determinant of phenotypic variance of molecular weight of low

density lipoprotein, 2347 Genetic heterogeneity in familial hypercholesterolemia: Two different

mutations affecting functions of low-density lipoprotein receptor, 1092 Neutron scattering study of human serum low density lipoprotein, 2270 Receptor-dependent hydrolysis of cholesterol esters contained in plasma

low density lipoprotein, 2925 Liposome



Introduction of enzymes, by immunoglobulin-coated liposomes, into lysosomes of deficient cells, 88

Stimulation and inhibition of anti-hapten responses in guinea pigs immunized with hybrid liposomes, 4582

Lipoteichoic acid Lipoteichoic acid: Specific inhibitor of autolysin activity in

pneumococcus, 1690 Mechanism of action of penicillin: Triggering of pneumococcal autolytic

enzyme by inhibitors of cell wall synthesis, 4162 Liquid crystal

Preparation of large monodomain phospholipid bilayer smectic liquid crystals, 840

Significant structure theory applied to mesophase system, 78 Lithium chloride split protein

Ribosomal protein essential for peptidyl transferase activity, 844 Liver

see also Hepatic; Hepatitis Cobalt induction of hepatic heme oxygenase: Evidence that cytochrome

P-450 is not essential for this enzyme activity (correction), 772 Factor-VIII-related antigen: Multiple molecular forms in human plasma,

5121 Increased particulate and decreased soluble guanylate cyclase activity in

regenerating liver, fetal liver, and hepatoma, 1965 Specific endocrine and hormonal receptor changes associated with liver

regeneration in adult rats, 4033 Synthesis of vitellogenin in cultures of male and female frog liver

regulated by estradiol treatment in vitro, 3172 Lizard

see Blanus cinereus; Diplometopon zarudnyi; Squamata Locus

see Gene Longevity, human


Loop space Bruhat decomposition for the loop space of compact group: New

approach to results of Bott, 4716 Dedekind's i-function and cohomology of infinite dimensional Lie

algebras, 2493 LSD

see d-Lysergic acid diethylamide Luciferase

Bacterial luciferase requires one reduced flavin for light emission, 3374 Chemical nature of bioluminescence systems in coelenterates, 1546

Luciferin Chemical nature of bioluminescence systems in coelenterates, 1546 Renilla-type luciferin extracted from calcium-activated photoproteins

aequorin, mnemiopsin, and berovin, 2530 Lumbricus

Kinetics of binding of carbon monoxide to Lumbricus erythrocruorin: A possible model, 4313

Luminol-substituted protein Enzymatic activation and trapping of luminol-substituted peptides and

proteins: Possible means of amplifying cytotoxicity of anti-tumor antibodies, 338

Lung Changes in relative levels of guanosine-3':5'-monophosphate-dependent



36 Subject Index


Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: Identification as eosinophil chemotactic factor of anaphylaxis, 4123

Lyase, /-replacement-specific Beta-cyanoalanine synthase: Purification and characterization, 1617

Lymphoblast, human Oncornavirus-like particles released from arginine-deprived human

lymphoblastoid cell lines, 4592 Lymphocyte

Binding of autologous erythrocytes to imnmature T-cells, 3201 Changes in ribosomal RNA processing paths in resting and

phytohemagglutinin-stimulated guinea pig lymphocytes, 3315 Differentiation of peripheral blood lymphocytes into cells bearing sheep

erythrocyte receptors in vitro by human thymic extract, 1175 Enhanced representation of HL-A antigens on human lymphocytes after



Modulation of lymphocyte mitogenesis, 1917 Monocytes rather than lymphocytes are the insulin-binding cells in


Polypeptide with lymphocyte-differentiating properties and probably represented universally in living cells, 11

Somatic rearrangement of chromosome 14 in human lymphocytes, 2071 Two stages in lymphocyte mediator production by differential

susceptibility to blockade using niridazole, 4569 Lymphocyte, bone-marrow-derived

Activation of T and B lymphocytes in vitro: Presence of 02-microglobulin determinants on allogeneic effect factor, 4577

Induction of immune response through interaction of helper cells with immune complex bound to surface of B cells, 4555

Surface proteins of mouse B and T cells, 157 Lymphocyte cytotoxicity

Lymphocyte cytotoxicity augmented by antibody to herpesvirus saimiri associated antigens, 1671

Lymphocyte cytotoxicity to autologous liver cells in chronic active hepatitis, 1301

Lymphocyte mediator production Two stages in lymphocyte mediator production by differential

susceptibility to blockade using niridazole, 4569 Lymphocyte stimulation

see also Phytohemagglutinin Antibodies reactive with cell surface carbohydrates, 1127 Changes in ribosomal RNA processing paths in resting and

phytohemagglutinin-stimulated guinea pig lymphocytes, 3315 Enhanced representation of HL-A antigens on human lymphocytes after


Modulation of lymphocyte mitogenesis, 1917 Periodate and concanavalin A induce blast transformation of rat

lymphocytes by indirect mechanism, 3590 Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes

in culture, 5026 Sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated

mouse lymphocytes, 1950 Lymphocyte, thymus-derived

see also Cell, thymus-derived Amino groups in formation of human lymphocyte-xenogeneic

erythrocyte rosettes; proposed mechanism for antigen recognition, 697 Recognition of immunoglobulin idiotypes by thymus-derived

lymphocytes, 2357 Surface proteins of mouse B and T cells, 157 Thymus-derived rat lymphocyte receptor for cell surface antigens is


Lymphokine Biologic and antigenic similarity of virus-induced migration inhibition

factor to conventional, lymphocyte-derived migration inhibition factor, 1641



Lymphoma see also Hodgkin's disease Concanavalin A receptors on surface membrane of lymphocytes from

patients with Hodgkin's disease and other malignant lymphomas, 1046' Cyclic AMP, nonessential regulator of cell cycle, 878 Growth characteristics of Epstein-Barr virus (EBV)-genome-negative

lymphoma line and its EBV-converted subline in vitro, 3518 Lymphocyte cytotoxicity augmented by antibody to herpesvirus saimiri

associated antigens, 1671 Lymphosarcoma, murine


Lymphotoxin release Separation of T cell subpopulations capable of DNA synthesis,


d-Lysergic acid diethylamide RNA synthesis in isolated brain nuclei after administration of d-lysergic

acid diethylamide (LSD) in vivo, 837


Lysis see also Cytolysis; Cytotoxicity

Lysis, cell-mediated Absence of H-2 antigens capable of reacting with cytotoxic T cells on

teratoma line expressing T/t locus antigen, 3661 Interaction of lymphocytes with lipid bilayer membranes: Model for

lymphocyte-mediated lysis of target cells, 2789 Lysis of leukemia cells by spleen cells of normal mice, 2780

Lysosome Bioregulation of lysosomal enzyme secretion from human neutrophils:


Cytochemical studies of Golgi apparatus, GERL, and lysosomes in neurons of dorsal root ganglia in mice, 508

Fetal mouse hearts: Model for studying ischemia, 2809 Fetal mouse hearts: Model for studying ischemia (correction), 4679 Hormonal effects on structure and catalytic properties of fructose

1,6-bisphosphatase, 2969 Introduction of enzymes, by immunoglobulin-coated liposomes, into

lysosomes of deficient cells, 88 Lymphokine-induced production and release of lysosomal enzymes by

macrophages, 2091 Lysozyme

New temperature-dependent conformational transition in lysozyme detected by carbon-13 nuclear magnetic resonance spectroscopy, 2095

Protein-water interaction studied by solvent 1H, 2H, and 170 magnetic relaxation, 2667

Lysyl-transfer ribonucleic acid synthetase (EC 6J1.1.6) Metabolites influence control of lysine transfer ribonucleic acid

synthetase formation in Escherichia coli K-12, 1364 Relationship of first step in protein synthesis to ppGpp: Formation of

A(5')ppp(5')Gpp, 2653

Macdonald's identities Dedekind's q-function and cohomology of infinite dimensional Lie

algebras, 2493 Macromolecular synthesis, regulation


Macromolecule, polyfunctional Group of thermodynamic potentials applicable to ligand binding by a

polyfunctional macromolecule, 1464 Turning wheel: Study in steady states, 3983

Macronucleus Absence of histone Fl in mitotically dividing, genetically inactive

nucleus, 2672 Macrophage

Comparison between macrophage activation and enhancement of nonspecific resistance to tumors by mycobacterial immunoadjuvants, 4105


Removal of senescent cells by human macrophages in situ, 3521 Macrophage migration inhibition test

Guinea pig transfer factor-like activity detected in vitro, 4573 Magnesium


Central role for magnesium in coordinate control of metabolism and growth in animal cells, 3551

Electrostatic basis of Mg++ inhibition of transmitter release (correction), 409

Role of magnesium in Escherichia coli alkaline phosphatase, 2989 Magnesium oxide, molten

Properties of molten magnesium oxide, 1026 Magnetic circular dichroism

Magnetic circular dichroism of molecules in dense media: Relation between magnetic circular dichroism and Hammett's constants, 452

Magnetic field Daily periodicity in the activity of a slide used to perform immunologic

reactions at a liquid-solid interface, 2462 Magnetic resonance

see Electron paramagnetic resonance; Nuclear magnetic resonance Magnetohydrodynamic equation

Theory of homogeneous dynamos in a rotating liquid sphere, 1496 Magnetohydrodynamics

Computer simulation of toroidal equilibrium and stability of a plasma in three dimensions, 926

Maize see Zea mays

Malaria parasite Coenzyme A requirement of malaria parasites: Coenzyme A precursors

affect extracellular development in vitro of Plasmodium lophurae, 1834


On primary structure and biosynthesis of histidine-rich polypeptide from malarial parasite Plasmodium lophurae, 3057

Maleic anhydride, 2,3-dimethyl Dissociation of bovine 6S procarboxypeptidase A by reversible

condensation with 2,3-dimethyl maleic anhydride: Application to partial characterization of subunit III, 2442

(N-Maleimidomethyl) ether, bis- Bis(N-maleimidomethyl) ether: Antisickling reagent, 4153




Malignant histiocytosis Oncornavirus-like particles from cultured bone marrow cells preceding

leukemia and malignant histiocytosis, 2804 Mammal, fossorial

Aggression patterns and speciation, 3250 Manganese(III) tetraphenylporphin halide

Resonance-Raman spectra of manganese(III) tetraphenylporphin halides, 433

Manganous ion Conformational change and cooperativity in actin filaments free of

tropomyosin, 3412 Mannan biosynthesis

Yeast manno-protein biosynthesis: Solubilization and selective assay of four mannosyltransferases, 3912

Mannoprotein Yeast manno-protein biosynthesis: Solubilization and selective assay of

four mannosyltransferases, 3912 Mannose


Mannosyl-glycopeptide Appearance of smaller mannosyl-glycopeptides on surface of a human

cell transformed by simian virus 40, 2687 Mannosyltransferase

Yeast manno-protein biosynthesis: Solubilization and selective assay of four mannosyltransferases, 3912

Mantle convection Gross thermodynamics of heat engines in deep interior Earth, 1555

Mathematics Almost all roots of c(s) = a are arbitrarily close to o- = 1/2, 1322 Analysis of subtractive algorithm for greatest common divisors, 4720 Bruhat decomposition for the loop space of compact group: New

approach to results of Bott, 4716 Characters of holomorphic discrete series, 3275 Complete solution of periodic Toda problem, 2879 Complexifications of real manifolds, 4210 Computer simulation of toroidal equilibrium and stability of a plasma in

three dimensions, 926 Connectivities Ri of Frechet spaces in variational topology, 2069 Dedekind's n-function and cohomology of infinite dimensional Lie

algebras, 2493 Deduction of semi-optimal mollifier for obtaining lower bound for No(T)

for Riemann's zeta-function, 294 Disjunction property implies numerical existence property, 2877 Exhaustion functions and Stein neighborhoods for smooth pseudoconvex

domains, 3279 General almost automorphy, 3815 Homology of congruence subgroups and K3(Z), 651 Inequalities in Fourier analysis on Rn, 638 Inequality among determinants, 3277 Infinitesimal generators and quasi-units in potential theory, 2498 Intertwining operators and automorphic forms for the metaplectic group,

1406 Lagrange multiplier method for convex programs, 1778 Limits of zeroes of recursively defined polynomials, 4209 Motion of a slightly compressible fluid, 539 Necessary and sufficient conditions for solvability of Lewy equation,

3287 On equimultiple subvarieties of algebroid hypersurfaces, 1425 On equimultiple subvarieties of algebroid hypersurfaces (correction),

3260 On some periodic Toda lattices, 1627 Phase problem in crystallography, 1699 Point estimates for probability moments, 3812 Pseudoconformal geometry of hypersurfaces in Cn+l, 2433 Singular integrals and the principal series, IV, 2459 Some fundamental groups in arithmetic of algebraic curves over finite

fields, 3281 Spectra of convolution operators on Lp spaces, 3285 Strongly nonlinear integral equations of Hammerstein type, 1937 Theorem on the Schwartz space of a reductive Lie group, 4718 Variational formula for principal eigenvalue for operators with maximum

principle, 780 Well-posed inverse spectral problems, 2496 X and Y operators for general linear transport processes, 1210

Matrix method Matrix method for fluctuations and noise in kinetic systems, 3807

Maturation promotion factor Induction of maturation (meiosis) in Xenopus laevis oocytes by three

organomercurials, 1574 Mean field model

On some modified spherical models, 4723 Megakaryocyte, mouse

Growth of mouse megakaryocyte colonies in vitro, 1744 Meiosis


Genetic analysis in dinoflagellate Crypthecodinium (Gyrodinium) cohnii: Unusual meiosis, 4546

Induction of maturation (meiosis) in Xenopus laevis oocytes by three organomercurials, 1574

Meiosis in Phycomyces, 4076 Single-strand scissions of chromosomal DNA during commitment to

recombination at meiosis, 1887 Meiotic karyotype

Electron microscopic observations on meiotic karyotype of diploid and

Subject Index 37

tetraploid Saccharomyces cerevisiae, 5056 Melanocyte stimulating hormone,

see Melanotropin Melanoma

Oncornavirus-like particles in human skin cancers, 3697 Melanotropin

Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone, 951

Melatonin Ontogenesis of biological clock for serotonin:acetyl coenzyme A

N-acetyltransferase in pineal gland of rat, 2814 Regulation of sensitivity to /3-adrenergic stimulation in induction of

pineal N-acetyltransferase, 1661 Members of the National Academy of Sciences USA

National Academy of Sciences USA: Classes, council, members, officers, sections, 3754

Membrane see also Cell surface; Lipid; Phospholipid Brownian motion in biological membranes, 3111 Diabetes mellitus: Changes in transport properties of isolated intestinal

microvillous membranes, 2027 DNA replication in vitro starting with an intact ,X174 phage, 3863 Establishment of tight junctions between epithelial cells, 2711 Magnetic resonance spectra of membranes, 1451 Membrane differences in peripheral blood lymphocytes from patients

with chronic lymphocytic leukemia and Hodgkin's disease, 2428 Neoantigens of membrane attack complex of human complement, 1687 Regulation of binding properties of nicotinic receptor protein by


Spectator-ion effect on passage of ions through membranes, 683 Third component of complement (C3): Structural properties in relation

to functions, 1989 Membrane assembly

Asymmetric orientation of phage coat protein in cytoplasmic membrane of Escherichia coli, 4749

Membrane, basement Synthesis of hemoglobin AiC in normal and diabetic mice: Potential

model of basement membrane thickening, 3687 Membrane, bileaflet


Membrane, cell Modulation of lymphocyte receptor mobility by locally bound

concanavalin A, 1579 Visualization of actin fibers associated with cell membrane in amoebae of

Dictyostelium discoideum, 1758 Membrane, cell surface

Concanavalin A receptors on surface membrane of lymphocytes from patients with Hodgkin's disease and other malignant lymphomas, 1046

Membrane, chlorophyll-containing Modification of intensity and direction of electron flow across bileaflet

membranes, 3407 Membrane conductance

Spike-forming model of neural membrane, 3468 Spike-forming model of neural membrane: Computer simulation of some

perfused axon experiments, 4859 Voltage-dependence of drug-induced conductance in frog neuromuscular

junction, 2140 Membrane damage

Neoantigens of membrane attack complex of human complement, 1687 Membrane electrical capacity


Membrane, electroplax Acetylcholine-receptor-mediated ion flux in electroplax membrane

preparations, 4371 Membrane enzyme

see Enzyme, membrane-bound Membrane, erythrocyte

Mechanism of cytolysis by complement: Insertion of C5b and C7 subunits of C5b,6,7 complex into phospholipid bilayers of erythrocyte membranes, 5076

Membrane fluidity Activation of adenylate cyclase by cholera toxin, 3438 Detection and ultrastructural localization of human smooth muscle

myosin-like molecules in human non-muscle cells by specific antibodies, 1359

Fatty acid chain flexibility in membranes of normal and transformed fibroblasts, 664

Fatty acids as modulators of membrane functions: Catecholamine-activated adenylate cyclase of turkey erythrocyte, 3433

Membrane fracture Alterations in envelope structure of heptose-deficient mutants of

Escherichia coli as revealed by freeze-etching, 5145 Membrane function


Membrane fusion Alamethicin-mediated fusion of lecithin vesicles, 2170

Membrane interaction Myelin structure transformed by dimethylsulfoxide, 3513

Membrane, lipid Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by

concanavalin A, 4409 Interaction of lymphocytes with lipid bilayer membranes: Model for

lymphocyte-mediated lysis of target cells, 2789



38 Subject Index

Membrane, Micrococcus lysodeikticus Antigenic and enzymatic architecture of Micrococcus lysodeikticus

membranes established by crossed immunoelectrophoresis, 3711 Membrane-microtubule interaction


Membrane, mitochondrial Thyroid hormone binding by component of mitochondrial membrane,

3225 Membrane, model

Alamethicin-mediated fusion of lecithin vesicles, 2170 Neutron diffraction studies on location of water in lecithin bilayer model

membranes, 376 Stimulation and inhibition of anti-hapten responses in guinea pigs

immunized with hybrid liposomes, 4582 Membrane mutant


Membrane, neural Spike-forming model of neural membrane, 3468 Spike-forming model of neural membrane: Computer simulation of some

perfused axon experiments, 4859 Membrane, nuclear


Nuclear pore complexes associated with a lamina, 1007 Membrane particle


Membrane particles on fracture faces of frozen myelin, 4046 Membrane permeability

Interaction of lymphocytes with lipid bilayer membranes: Model for lymphocyte-mediated lysis of target cells, 2789

Membrane phosphorylation Action of feedback regulator on adenylate cyclase, 1773

Membrane, plasma Activation of adenylate cyclase by cholera toxin, 3438 Chitin synthetase zymogen is attached to yeast plasma membrane, 3952 Cholera toxin activation of adenylate cyclase in cancer cell membrane

fragments, 2572 Colchicine affects kinetics of concanavalin A-mediated agglutination of


Increased particulate and decreased soluble guanylate cyclase activity in regenerating liver, fetal liver, and hepatoma, 1965

Plasma membrane alteration associated with malignant transformation in culture, 3594

Structural change of plasma membrane induced by oncogenic viruses: Quantitative studies with freeze-fracture technique, 1695


Ultrastructural localization of insulin receptors on adipocytes, 3526 Membrane, postsynaptic

Molecular model of postsynaptic potential, 1749 Membrane potential

Reversible effects of chaotropic agents on proton permeability of Escherichia coli membrane vesicles, 3387

Membrane protein see Protein, membrane

Membrane, rat lymphocyte Mobility of cholera toxin receptors on rat lymphocyte membranes, 3.844

Membrane receptor Antibodies reactive with cell surface carbohydrates, 1127

Membrane structure Conjugated polyene fatty acids as membrane probes, 1649 Crosslinking and labeling of membrane proteins by

transglutaminase-catalyzed reactions, 2568 Differences in membrane fluidity and structure in contact-inhibited and

transformed cells (correction), 1217 Neutron diffraction studies on location of water in lecithin bilayer model

membranes, 376 Preparation of large monodomain phospholipid bilayer smectic liquid

crystals, 840 Structural change of plasma membrane induced by oncogenic viruses:

Quantitative studies with freeze-fracture technique, 1695 X-ray diffraction studies of human erythrocyte membrane structure, 531

Membrane, thylakoid Light-dependent absorption and selective scattering changes at 518 nm

in chloroplast thylakoid membranes, 3858 Thylakoid membrane polypeptides of Chlamydomonas reinhardtii:


Membrane transport Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams,

1291 Membrane vesicle

Active transport of calcium in inverted vesicles of Escherichia coli (correction), 2833


Reversible effects of chaotropic agents on proton permeability of Escherichia coli membrane vesicles, 3387

Ubiquinone-mediated coupling of NADH dehydrogenase to active transport in membrane vesicles from Escherichia coli, 3970

Memory Dual regulation of adenylate cyclase accounts for narcotic dependence


and tolerance, 3092 Effect of acetoxycycloheximide on rate of accumulation of cerebral




Meningioma, human Simian virus 40-related antigens in three human meningiomas with

defined chromosome loss, 609 Meromyosin, heavy, subfragment-1

Conformational change and cooperativity in actin filaments free of tropomyosin, 3412

Mesophase system Significant structure theory applied to mesophase system, 78

Metabolic control see also Control; Regulation Breaking of seed dormancy by catalase inhibition, 306

Metabolism see also specific compounds; Biosynthetic pathways Abnormal collagen metabolism in cultured cells in osteogenesis

imperfecta, 586 Chicken neutrophils: Oxidative metabolism in phagocytic cells devoid of

myeloperoxidase, 5012 Control of the synthesis of a single enzyme by multiple regulatory

circuits in Neurospora crassa, 1240 [13C]Valine metabolism in methylmalonicacidemia using nuclear

magnetic resonance: Propionate as obligate intermediate, 3692 Follicle-stimulating hormone stimulates estradiol-17/ synthesis in

cultured Sertoli cells, 2677 Genetic complementation in heterokaryons of human fibroblasts

defective in cobalamin metabolism, 3181 Genetic evidence on organization and action of qa-I gene product:

Protein regulating induction of three enzymes in quinate catabolism in Neurospora crassa, 553


Inactivation of rabbit muscle phosphorylase phosphatase by cyclic AMP-dependent kinase, 3004

Influence of novel hypophyseal factor on steroid metabolism in cultured hepatoma cells, 4986



Nuclear and cytoplasmic poly(adenylic acid), 3580 Plasmin digests of S-carbamidomethylated human growth hormone, 1684 Purine metabolism in murine virus-induced erythroleukemic cells during

differentiation in vitro, 1630 Reversible dissociation of carbamoyl phosphate synthase-aspartate

transcarbamoylase-dihydroorotase complex from ovarian eggs of Rana catesbeiana: Effect of uridine triphosphate and other modifiers, 1712

Role of epithelial architecture and intracellular metabolism in proline uptake and transtubular reclamation in PRO/Re mouse kidney, 1431



Metalloenzyme I'C nuclear magnetic resonance studies on mechanism of action of

carbonic anhydrase, 454 Cobalt(III), probe of metal binding sites of Escherichia coli alkaline

phosphatase, 394 Homologous relationship between thermolysin and neutral protease A of

Bacillus subtilis, 4341 Role of magnesium in Escherichia coli alkaline phosphatase, 2989

Metalloporphyrin Resonance Raman spectra of manganese(III) tetraphenylporphin halides,

433 Metal-metal distance probe

Energy transfer between terbium(III) and cobalt(II) in thermolysin: New class of metal-metal distance probes, 4764

Metal-phosphate interaction Theoretical studies of metal-phosphate interactions, 3794

Metal, transition Maximum-valence radii of transition metals, 3799 Valence-bond theory of compounds of transition metals, 4200

Metaplectic group Intertwining operators and automorphic forms for the metaplectic group,

1406 Metastable states in enzymes

Extraordinary dielectric properties of biological materials and action of enzymes, 4211

Meteorite, primitive Condensation time of solar nebula from extinct 1291 in primitive

meteorites, 268 Methemoglobin

Redox equilibria of liganded forms of methemoglobin, 3382 X-ray absorption spectroscopy using synchrotron radiation for structural

investigation of organometallic molecules of biological interest, 2340 Methionine



Methionine, N-acetyl Nuclear coupling of 3S and nature of free radicals in irradiated crystals




of cysteine hydrochloride and N-acetyl methionine, 3486 Methodology


Methodology (culturing) Growth of mouse megakaryocyte colonies in vitro, 1744 Immunosurgery of mouse blastocyst, 5099

Methodology (genetics and selection) Biochemical lesions used for selection of human cells with hybrid

cytoplasms, 1812 Biochemical procedure for production of small deletions in simian virus

40 DNA, 1392 Carcinogens as mutagens: Bacterial tester strains with R factor plasmids,

979 Cloning, isolation, and characterization of replication regions of complex


a specific gene, 3961 Fusion of Escherichia coli lac genes to ara promoter: Bacteriophage

mu-1 insertions, 809 Isolation of Escherichia coli mutants defective in enzymes of membrane

lipid synthesis, 2274 Selection for conditional gametogenesis in Chlamydomonas reinhardi,

3652 Methodology (microscopy)

Antibody against tubulin: Specific visualization of cytoplasmic microtubules in tissue culture cells, 459

Cell-surface-associated nucleic acid in tumorigenic cells made visible with platinum-pyrimidine complexes by electron microscopy, 928

Protein-free spreading of double- and single-stranded nucleic acid molecules, 83

Scanning transmission ion microscope with field ion source, 1826 T antigen binds to simian virus 40 DNA at the origin of replication, 1605 Use of gene 32 protein staining of single-strand polynucleotides for gene


Methodology (purification and preparation) Affinity chromatography of viral DNA polymerases on pyran-Sepharose,

1142 Blue dextran-Sepharose: Affinity column for the dinucleotide fold in

proteins, 669 Chromosome measurement and sorting by flow systems, 1231 Cloning, isolation, and characterization of replication regions of complex


a specific gene, 3961 Isolation of bacteriophage lambda A-gene protein, 581 Isolation of rabbit reticulocyte initiation factors by means of heparin

bound to Sepharose, 2352 Method for the isolation of specific tRNA precursors, 4790 Nerve growth factor crystallized from mouse submaxillary glands, 777 Partial purification of glucocorticoid receptor, 3849 Preparation of large monodomain phospholipid bilayer smectic liquid

crystals, 840 Rapid and specific method for isolation of thiol-containing peptides from

large proteins by thiol-disulfide exchange on solid support, 3029 Separation of 1-acylglycerolphosphate acyltransferase and


Separation of "estrogen-induced" protein from phosphoprotein phosphatase activity of immature rat uterus, 2631


Methodology (qualitative and quantitative analysis) Adenine formation from adenosine by mycoplasmas: Adenosine

phosphorylase activity, 1401 Antigenic and enzymatic architecture of Micrococcus lysodeikticus

membranes established by crossed immunoelectrophoresis, 3711 Brain receptors for antipsychotic drugs and dopamine: Direct binding

assays, 4376 Carcinogens as mutagens: Bacterial tester strains with R factor plasmids,

979 Cholesterol synthesis in man measured by isotope kinetics of squalene,

4612 Chromosome measurement and sorting by flow systems, 1231 Competitive protein binding assay for methotrexate, 3683 Detection of carcinogens as mutagens in Salmonella/microsome test:

Assay of 300 chemicals, 5135 Differential activity staining: Use in characterization of guanylyl-specific

ribonuclease in genus Ustilago, 4914 Donnan potential of rabbit skeletal muscle myofibrils: I.

Electrofluorochromometric detection of potential, 1325 Early effect of interferon on mouse leukemia cells cultivated in

chemostat, 2265 Guinea pig transfer factor-like activity detected in vitro, 4573 High resolution 31p nuclear magnetic resonance studies of intact yeast

cells, 4966 Isolation of bacteriophage lambda A-gene protein, 581 Leukocyte migration inhibitory factor (LMIF) induced by concanavalin

A: Standardized microassay for production in vitro, 3197 Measurement of human dopamine-/-hydroxylase in serum by

homologous radioimmunoassay, 750 Metabolic pathways of 7,12-dimethylbenz[a]anthracene in hepatic

microsomes, 2601 o-Phthalaldehyde: Fluorogenic detection of primary amines in picomole

range: Comparison with fluorescamine and ninhydrin, 619 Partially purified simian virus 40 T antigen interacts with circular viral

DNA molecules, 1960

Subject Index 39

Preparation and microbial decomposition of synthetic [14C]lignins, 2515 Quantitation of sensory response in bacterial chemotaxis, 710 Radioimmune determination of hypoxanthine phosphoribosyltransferase

crossreacting material in erythrocytes of Lesch-Nyhan patients, 4147 Sepharose-insulin as tool for study of insulin action, 248 Synthesis and differentiation of plasma proteins in cultured embryonic

chicken liver cells: System for study of regulation of protein synthesis, 5007

Methodology (spectroscopy) 13C-nuclear magnetic resonance study of [85% 13C-enriched

prolinejthyrotropin releasing factor: 13C-13C vicinal coupling constants and conformation of proline residue, 4948

Conjugated polyene fatty acids as membrane probes, 1649 Crosslinking and labeling of membrane proteins by

transglutaminase-catalyzed reactions, 2568 Determination of iron-sulfur distances in rubredoxin by x-ray absorption

spectroscopy, 4003 Donnan potential of rabbit skeletal muscle myofibrils: I.

Electrofluorochromometric detection of potential, 1325 Energy transfer between terbium(III) and cobalt(II) in thermolysin: New

class of metal-metal distance probes, 4764 Functional intermediates in reaction of cytochrome oxidase with oxygen,

1635 High resolution 31P nuclear magnetic resonance studies of intact yeast

cells, 4966 Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase

A: Monitor of catalytic events, 3930 X-ray absorption spectroscopy using synchrotron radiation for structural

investigation of organometallic molecules of biological interest, 2340 X-ray diffraction studies of human erythrocyte membrane structure, 531

Methodology (structure determination) Asymmetric orientation of phage coat protein in cytoplasmic membrane

of Escherichia coli, 4749 13C-nuclear magnetic resonance study of [85% 13C-enriched

proline]thyrotropin releasing factor: 13C-13C vicinal coupling constants and conformation of proline residue, 4948

Conjugated polyene fatty acids as membrane probes, 1649 Crosslinking and labeling of membrane proteins by

transglutaminase-catalyzed reactions, 2568 Determination of iron-sulfur distances in rubredoxin by x-ray absorption

spectroscopy, 4003 Energy transfer between terbium(III) and cobalt(II) in thermolysin: New

class of metal-metal distance probes, 4764 Functional intermediates in reaction of cytochrome oxidase with oxygen,

1635 Translation of thyroglobulin 33S messenger RNA as means of

determining thyroglobulin quaternary structure, 3839 X-ray absorption spectroscopy using synchrotron radiation for structural

investigation of organometallic molecules of biological interest, 2340 X-ray diffraction studies of human erythrocyte membrane structure, 531

Methodology (synthesis) Biochemical procedure for production of small deletions in simian virus

40 DNA, 1392 Enzymes as reagents in peptide synthesis: Enzymatic removal of amine

protecting groups, 2193 32P-labeling of ribonucleic acids at 5'-ends after isolation, 314 Preparation and microbial decomposition of synthetic [14C]lignins, 2515 Simian virus 40 DNA directs synthesis of authentic viral polypeptides in

linked transcription-translation cell-free system, 1922 Methotrexate

Competitive protein binding assay for methotrexate, 3683 New approach to antifolate treatment of certain cancers as demonstrated

in tissue culture, 4018 Methylation




Methylgalactoside transport Binding protein-independent substrate translocation by

methylgalactoside transport system of Escherichia coli K12, 423 Methylglyoxal

Interaction of glyoxal and methylglyoxal with biogenic amines, 1610 Methylglyoxal bis(guanylhydrazone)


Methylmalonicacidemia [3Cj]Valine metabolism in methylmalonicacidemia using nuclear

magnetic resonance: Propionate as obligate intermediate, 3692 Genetic complementation in heterokaryons of human fibroblasts




Micaceous metaquartzite Abiotic, graphitic microstructures in micaceous metaquartzite about

3760 million years old from Southwestern Greenland: Early Precambrian microfossils, 1206

Microcirculation Central noradrenergic regulation of cerebral blood flow and vascular

permeability, 3726



40 Subject Index

Microfibril assembly Microfibril assembly by granules of chitin synthetase, 2706

Microfilament Antibody against tubulin: Specific visualization of cytoplasmic

microtubules in tissue culture cells, 459 Differences among myosins synthesized in non-myogenic cells,

presumptive myoblasts, and myoblasts, 4999 Microfossil, early Precambrian

Abiotic, graphitic microstructures in micaceous metaquartzite about 3760 million years old from Southwestern Greenland: Early Precambrian microfossils, 1206

02-Microglobulin Activation of T and B lymphocytes in vitro: Presence of 02-microglobulin

determinants on allogeneic effect factor, 4577 Structure and function of immunoglobulin domains: Studies with

beta2-microglobulin on role of intrachain disulfide bond, 548 Micronucleus

Absence of histone Fl in mitotically dividing, genetically inactive nucleus, 2672

Microscope, ion, scanning transmission Scanning transmission ion microscope with field ion source, 1826

Microscopy see Electron microscopy; Methodology (microscopy)

Microtubule Antibody against tubulin: Specific visualization of cytoplasmic

microtubules in tissue culture cells, 459 Assembly of chick brain tubulin onto flagellar microtubules from

Chlamydomonas and sea urchin sperm, 1122 Assembly of microtubules onto kinetochores of isolated mitotic

chromosomes of HeLa cells, 4023 Cyclic AMP-dependent endogenous phosphorylation of

microtubule-associated protein, 177 Cytoplasmic microtubules in normal and transformed cells in culture:

Analysis by tubulin antibody immunofluorescence, 4981 Inhibition of tubulin assembly by RNA and other polyanions: Evidence

for required protein, 3570 Membrane-microtubule interactions: Concanavalin A capping induced

redistribution of cytoplasmic microtubules and colchicine binding proteins, 4976

Microtubule phosphorylation during cell cycle of HeLa cells, 1161 Microtubule assembly

Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro, 2696

Protein factor essential for microtubule assembly, 1858 Microvillus



Migration inhibition factor Biologic and antigenic similarity of virus-induced migration inhibition

factor to conventional, lymphocyte-derived migration inhibition factor, 1641

Mineralized tissue Direct identification of the calcium-binding amino acid

-y-carboxyglutamate in mineralized tissue, 3925 Minicell


Replicative intermediates of colicin El plasmid DNA in minicells, 829 Very stable prokaryotic messenger RNA in chromosomeless Escherichia

coli minicells, 2900 Mismatch repair

Mismatch repair in heteroduplex DNA, 2202 Mitochondrion

Biosynthesis of polypeptides of cytochrome c oxidase by isolated mitochondria, 172


Mitochondrial carnitine acylcarnitine translocase system, 883 Paired moving charge model of energy coupling: III. Intrinsic ionophores

in energy coupling systems, 896 Paired moving charges in mitochondrial energy coupling: II. Universality

of principles for energy coupling in biological systems, 253 Physical basis of charge pairing in mitochondria, 2058 Thyroid hormone binding by component of mitochondrial membrane,

3225 Translation of RNA that contains polyadenylate from yeast

mitochondria in Escherichia coli ribosomal system, 4293 Mitogen


Mitogenesis Enhanced representation of HL-A antigens on human lymphocytes after


Modulation of lymphocyte mitogenesis, 1917 Mitogenic activity


Mitomycin C Proteolytic cleavage of bacteriophage lambda repressor in induction, 147

Mitosis Microtubule phosphorylation during cell cycle of HeLa cells, 1161

Mitotic apparatus Presence of actin during chromosomal movement, 2451

Mnemiopsin Renilla-type luciferin extracted from calcium-activated photoproteins


aequorin, mnemiopsin, and berovin, 2530 Mold

see Fungus; Slime mold Molecular contact

Hemoglobin interaction in sickle cell fibers: Theoretical approaches to molecular contacts, 1330

Molecular fragment, floating spherical Gaussian orbital, self-consistent field calculation


Molecular hybridization Relationship in nucleic acid sequences between mouse mammary tumor

virus variants, 4635 Molecular orbital calculation


Molecular structure Description of molecular 'structure (Symposium), 763

Molecular weight Genetic determinant of phenotypic variance of molecular weight of low

density lipoprotein, 2347 Mollifier, semi-optimal

Deduction of semi-optimal mollifier for obtaining lower bound for No(T) for Riemann's zeta-function, 294

Mollusc see also Aplysia; Tindaria Social structuring of mammalian populations and rate of chromosomal

evolution, 5061 Moloney virus

see Leukemia virus, murine; Sarcoma virus Monellin

Crystallization and crystal data of monellin, 398 Monoclonal component

Immunochemical evidence for common variable region in three immunoglobulin classes in the same individual, 4115

Monocyte Monocytes rather than lymphocytes are the insulin-binding cells in


Monophenol monooxygenase (EC 1.14.18.1) Melanoma cells resistant to inhibition of growth by melanocyte

stimulating hormone, 951 Morphine

Morphine receptors as regulators of adenylate cyclase activity, 590 Morphogenesis


Guanosine metabolism and regulation of fruiting body construction in Dictyostelium discoideum, 4479

Morphogenetic gradient Central connections of receptors on rotated and exchanged cerci of

crickets, 966 Mosquito

see Aedes aegypti; Culiseta inornata Mosquito pathogen

Life history of Coelomomyces psorophorae, 693 Motor output

Coordinated motor output in hindlimb of 7-day chick embryo, 1245 Mouse

see also Mus Mouse, athymic nude

Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice, 4971

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro, 4435

Mouse, diabetic Synthesis of hemoglobin Aic in normal and diabetic mice: Potential

model of basement membrane thickening, 3687 Mouse, genetically mosaic

Normal genetically mosaic mice produced from malignant teratocarcinoma cells, 3585

Mucopolysaccharide Enhancement of somatomedin titers of normal and hypopituitary sera by

addition of L-triiodothyronine in vitro at physiological concentrations, 604

Mucopolysaccharides associated with nuclei of cultured mammalian cells, 2032

Mucor rouxii Microfibril assembly by granules of chitin synthetase, 2706

Multiplier transformation Spectra of convolution operators on Lp spaces, 3285

Muramidase see Lysozyme

Mus see also Mouse Effect of castration and testosterone replacement on circadian

pacemaker in mice (Mus musculus), 3744 Isolation from Asian mouse Mus caroli of endogenous type C virus

related to infectious primate type C viruses, 2315 Muscle

see also Myogenesis Contraction of isolated smooth muscle cells by ionophore A23187, 4459 Donnan potential of rabbit skeletal muscle myofibrils: I.

Electrofluorochromometric detection of potential, 1325 Intramolecular crosslinking of tropomyosin via disulfide bond formation:

Evidence for chain register, 3377 Matrix method for fluctuations and noise in kinetic systems, 3807 Molecular mechanism for oscillation in flagella and muscle, 3102





Synthesis of acetylcholine receptor by denervated rat diaphragm muscle, 1368

Muscular dystrophy Interaction of glyoxal and methylglyoxal with biogenic amines, 1610

Mutagen, chemical Carcinogens as mutagens: Bacterial tester strains with R factor plasmids,

979 Cell cycle-dependent induction of mutations along yeast chromosome,

1179 Chemical induction of sperm abnormalities in mice, 4425 Detection of carcinogens as mutagens in Salmonella/microsome test:

Assay of 300 chemicals, 5135 Hair dyes are mutagenic: Identification of a variety of mutagenic

ingredients, 2423 Mutagenic and cytotoxic activity of benzo[a]pyrene 4,5-, 7,8-, and

9,10-oxides and the six corresponding phenols, 3176 Mutagenicity of chloroacetaldehyde, a possible metabolic product of


Salmonella mutants associated with germfree rats: Site specific model to detect carcinogens as mutagens, 4607

Mutagenesis Site-directed mutagenesis: Extracistronic mutation affecting in vitro

propagation of bacteriophage Q/3 RNA, 367 Spontaneous and induced mutagenesis in western equine

encephalomyelitis virus in chick embryo cells with different repair activity, 386

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype, 1427

Mutant see also specific organisms

Mutant, cytoplasmic Cytoplasmic mutants of Saccharomyces cerevisiae with specific lesions

in cytochrome oxidase, 2054 Mutant, temperature-sensitive


Thermolabile T (tumor) antigen from cells transformed by temperature-sensitive mutant of simian virus 40, 4351

Mutation, conditional-lethal Conditional-lethal mutations that suppress genetic defects in

morphogenesis by altering structural proteins, 2738 Mutation, germinal and somatic

Mutation and childhood cancer: Probabilistic model for incidence of retinoblastoma, 5116

Mutation, neutral Interlocus variation of genetic distance and neutral mutation theory,

2758 Linkage disequilibrium over space and time in natural populations of

Drosophila montana, 4095 Mutation, pleiotropic


Mutation pressure Statistical analyses of Drosophila and human protein polymorphisms,

3194 Mutator activity

Induction of error-prone repair as consequence of DNA ligase deficiency in Escherichia coli, 4645

Myasthenia gravis Immunological relationship between acetylcholine receptor and thymus:

A possible significance in myasthenia gravis, 1456 Mycobacteria

Comparison between macrophage activation and enhancement of nonspecific resistance to tumors by mycobacterial immunoadjuvants, 4105


Mycoplasma Adenine formation from adenosine by mycoplasmas: Adenosine

phosphorylase activity, 1401 Myelin

Membrane particles on fracture faces of frozen myelin, 4046 Myelin structure transformed by dimethylsulfoxide, 3513

Myeloma, mouse Variants of a mouse myeloma cell line that synthesize immunoglobulin

heavy chains having an altered serotype, 1427 Myeloma protein

see also Antibody; Immunoglobulin Recognition of immunoglobulin idiotypes by thymus-derived

lymphocytes, 2357 Myeloperoxidase

Chicken neutrophils: Oxidative metabolism in phagocytic cells devoid of myeloperoxidase, 5012

Myofiber formation Myogenesis of avian striated muscle in vitro: Role of collagen in

myofiber formation, 2729 Myofibril

Donnan potential of rabbit skeletal muscle myofibrils: I. Electrofluorochromometric detection of potential, 1325

Myogenesis see also Muscle Differences among myosins synthesized in non-myogenic cells,

presumptive myoblasts, and myoblasts, 4999 Effect of oncogenic virus on muscle differentiation, 4051 Effects of cytochalasin B and colcemide on myogenic cultures, 513

Subject Index 41


Myoglobin Oxygen and carbon monoxide binding to synthetic analogs of myoglobin

and hemoglobin active sites, 1166 Myohemerythrin

Tertiary structure of myohemerythrin at low resolution, 2160 Myosin

Differences among myosins synthesized in non-myogenic cells, presumptive myoblasts, and myoblasts, 4999


Motion of subfragment-1 in myosin and its supramolecular complexes: Saturation transfer electron paramagnetic resonance, 1729

Organization of actin and myosin in normal and transformed cultured cells, 994

Oxygen exchange in y-phosphoryl group of protein-bound ATP during Mg2+-dependent adenosine triphosphatase activity of myosin, 2592

Myosin-like molecule Detection and ultrastructural localization of human smooth muscle

myosin-like molecules in human non-muscle cells by specific antibodies, 1359


Myotube forming factor Myogenesis of avian striated muscle in vitro: Role of collagen in

myofiber formation, 2729 Myotube, skeletal

Cholinergic synapses formed between dissociated sympathetic neurons and skeletal myotubes of rat in cell culture, 1955

Myxococcus xanthus Regulation of development in Myxococcus xanthus: Effect of 3':5'-cyclic

AMP, ADP, and nutrition, 518

Naloxone Failure of opiate antagonist naloxone to modify hypnotic analgesia, 2041

Narcotic dependence see also Drug tolerance Dual regulation of adenylate cyclase accounts for narcotic dependence

and tolerance, 3092 Morphine receptors as regulators of adenylate cyclase activity, 590

National Academy of Sciences USA Description of molecular structure (Symposium), 763 National Academy of Sciences USA, Annual Meeting, April, 1975, 2837 National Academy of Sciences USA: Classes, council, members, officers,

sections, 3754 National Science Foundation

A foundation for research (Symposium), 2843 National Science Foundation: Origins, hopes, and aspirations

(Symposium), 2839 NSF and science education-Who, why, and how did it work out

(Symposium), 2848 Whither NSF?-The higher derivatives (Symposium), 2853

Natural selection Aggression patterns and speciation, 3250 Genetic variation as a test of natural selection, 2145 Group selection, altruism, reinforcement, and throwing in human

evolution, 3748 Linkage disequilibrium over space and time in natural populations of

Drosophila montana, 4095 Natural selection and evolution of reproductive effort, 2227 Theory of evolution above the species level, 646 Theory of group selection, 143

Nebula, solar Condensation time of solar nebula from extinct 129I in primitive

meteorites, 268 Neighbor exclusion binding


Nematode see Caenorhabditis elegans

Neonate Folate binding factor in normal umbilical cord serum purified, 4261

Nerve Components of 02-uptake by excised frog nerve dependent upon

externally supplied sodium ions, 3988 Nerve growth factor

Effect of nerve growth factor on cyclic AMP levels in superior cervical ganglia of rat, 4769

Nerve growth factor crystallized from mouse submaxillary glands, 777 Nerve growth factor induces volume increase and enhances tyrosine



Nerve growth factor secreted by mouse neuroblastoma cells in culture, 1895


Nervous system Biochemically differentiated mouse glial lines carrying a nervous system

specific cell surface antigen (NS-1), 1927 Effect of hypothalamic deafferentation on thyrotropin-releasing hormone

levels in rat brain, 4177 - ' Impulse conduction along central axons, 5156



42 Subject Index

Neural development Ectopic neurons and aberrant connections during neural development,

4455 Repair of ultraviolet irradiation damage to cytoplasmic component

required for neural induction in amphibian egg, 1235 Neural membrane

Spike-forming model of neural membrane, 3468 Spike-forming model of neural membrane: Computer simulation of some

perfused axon experiments, 4859 Neural regulation


Neural specificity Coordinated motor output in hindlimb of 7-day chick embryo, 1245

Neuraminic acid Cell-surface-associated nucleic acid in tumorigenic cells made visible

with platinum-pyrimidine complexes by electron microscopy, 928 Neurite outgrowth

Regulation of protein synthesis at translational level in neuroblastoma cells, 2289

Neuroblast, adrenergic Cholinergic differentiation of presumptive adrenergic neuroblasts in

interspecific chimeras after heterotopic transplantations, 728 Neurocytology

Receptor synapses without synaptic ribbons in cat cochlea, 3599 Neuroembryology

Coordinated motor output in hindlimb of 7-day chick embryo, 1245 Neurohypophyseal hormone


Neuroleptic drug Brain receptors for antipsychotic drugs and dopamine: Direct binding

assays, 4376 Neuromuscular junction

Cholinergic synapses formed between dissociated sympathetic neurons and skeletal myotubes of rat in cell culture, 1955

Electrostatic basis of Mg++ inhibition of transmitter release (correction), 409

1-Pyrene-butyrylcholine: A fluorescent probe for the cholinergic system, 3097

Voltage-dependence of drug-induced conductance in frog neuromuscular junction, 2140

Neuron Cholinergic synapses formed between dissociated sympathetic neurons

and skeletal myotubes of rat in cell culture, 1955 Circadian rhythm of neuron R15 of Aplysia californica: In vivo

photoentrainment, 2408 Cytochemical studies of Golgi apparatus, GERL, and lysosomes in

neurons of dorsal root ganglia in mice, 508 Ectopic neurons and aberrant connections during neural development,

4455 Mouse SmI cortex: Qualitative and quantitative classification of

Golgi-impregnated barrel neurons, 2165 Ultrastructural localization of tyrosine hydroxylase in noradrenergic

neurons of brain, 659 Neuronal cell line

New cell surface antigens in rat defined by tumors of the nervous system, 1296

Neuronal property Neuronal properties of hybrid neuroblastoma X sympathetic ganglion

cells, 4923 Neuronal specificity


Neurophysiology Impulse conduction along central axons, 5156

Neurospora crassa Aggregated multienzyme system influences transient time: Kinetic

evidence for compartmentation by aromatic-amino-acid-synthesizing complex of Neurospora crassa, 4218

Control of the synthesis of a single enzyme by multiple regulatory circuits in Neurospora crassa, 1240


Induction by RNA of inositol independence in Neurospora crassa, 642 Neurotoxin

Acetylcholine receptors at neuromuscular synapses: Phylogenetic differences detected by snake a-neurotoxins, 3245

Cooperative activation of action potential Na+ ionophore by neurotoxins, 1782


Neurotransmitter Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma

cells, 3472 Regulation of sensitivity to /-adrenergic stimulation in induction of

pineal N-acetyltransferase, 1661 Neutralizing factor

Virus-specific neutralization by soluble non-immunoglobulin factor found naturally in normal mouse sera, 5071

Neutron scattering Neutron -a';l i(eriig ii(.-asl(ii<'i('li- -f .(paration and shape of proteins in

30S ribo-o,lll tIl)Illlil ,i' ..f -.i:,,:'.? '':o coli: S2-S5, S5-S8, S3-S7, 3888 Neutron scattering study of human serum low density lipoprotein, 2270

Neutrophil see also Leukocyte Bioregulation of lysosomal enzyme secretion from human neutrophils:




Newcastle disease virus Inhibition by interferon of delayed-type hypersensitivity in mouse, 1753 Methylation of messenger RNA of Newcastle disease virus in vitro by

virion-associated enzyme, 2611 Nicotinamide

Poly(ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb, 1852

Nicotinamide adenine dinucleotide Macromolecular enzymatic product of NAD+ in liver mitochondria, 1436 NAD-dependent inhibition of protein synthesis by Pseudomonas

aeruginosa toxin, 2284 Nicotinamide adenine dinucleotide in action of cholera toxin in vitro,

2064 Nicotinamide-adenine dinucleotide phosphate (reduced) cytochrome

reductase (EC 1.6.2.4) Cobalt induction of hepatic heme oxygenase: Evidence that cytochrome

P-450 is not essential for this enzyme activity (correction), 772 Nicotinamide-adenine dinucleotide, reduced, dehydrogenase


Nicotinamide 1,N6-ethenoadenine dinucleotide Dynamic and static quenching of 1,N6-ethenoadenine fluorescence in

nicotinamide 1,N6-ethenoadenine dinucleotide and in 1,N6-etheno-9-[3-(indol-3-yl)propyl]adenine, 3966

Ninhydrin o-Phthalaldehyde: Fluorogenic detection of primary amines in picomole

range: Comparison with fluorescamine and ninhydrin, 619 Niridazole


Nitrogen fixation Microbial production of ammonium ion from nitrogen, 136 Potential for nitrogen fixation in maize genotypes in Brazil, 2389

Nitrogen metabolism Control of the synthesis of a single enzyme by multiple regulatory

circuits in Neurospora crassa, 1240 Nitrogen oxides

Estimates of stratospheric pollution by analytic model, 4711 Nitrosourea, ethyl


N,MR see Nuclear magnetic resonance

Noise Matrix method for fluctuations and noise in kinetic systems, 3807 "Spshing noise": Biological significance of its attraction and

nonattraction by birds, 1411 Noradrenergic action, central

Control of meal size by central noradrenergic action, 3740 Noradrenergic system, central


Norepinephrine Control of meal size by central noradrenergic action, 3740 Effect of acetoxycycloheximide on rate of accumulation of cerebral



v (nu) Body Analysis of DNA of isolated chromatin subunits, 3978

Nuclear envelope Nuclear pore complexes associated with a lamina, 1007

Nuclear magnetic relaxation Protein-water interaction studied by solvent 1H, 2H, and 170 magnetic

relaxation, 2667 Nuclear magnetic resonance

Alkali ion-DNA interaction as reflected in nuclear relaxation rates of 23Na and 87Rb, 245




13C-nuclear magnetic resonance study of [85% 13C-enriched proline]thyrotropin releasing factor: 13C-13C vicinal coupling constants and conformation of proline residue, 4948


Headgroup conformation and lipid-cholesterol association in phosphatidylcholine vesicles: zlPlH} nuclear Overhauser effect, 3477

High resolution 31p nuclear magnetic resonance studies of intact yeast cells, 4966

Magnetic resonance spectra of membranes, 1451 New temperature-dependent conformational transition in lysozyme

detected by carbon-13 nuclear magnetic resonance spectroscopy, 2095 Nuclear magnetic resonance spectroscopy: Reinvestigation of carbon-13

spin-lattice relaxation time measurements of amino acids, 1599 Nuclear magnetic resonance spectrum of living tunicate blood cells and

structure of native vanadium chromogen, 2217 Photooxidation of chlorins by quinones studied by nuclear magnetic

resonance techniques, 3265




31p magnetic resonance of tRNA, 3482 Proton nuclear magnetic resonance of spin-labeled Escherichia coli

tRNAfiMet, 2582 Sidechain torsional potentials and motion of amino acids in proteins:

Bovine pancreatic trypsin inhibitor, 2002 Tertiary hydrogen bonds in solution structure of transfer RNA, 2049

Nuclear Overhauser effect Applications of natural-abundance nitrogen-15 nuclear magnetic

resonance to large biochemically important molecules, 4696 Headgroup conformation and lipid-cholesterol association in

phosphatidylcholine vesicles: 31p{'H} nuclear Overhauser effect, 3477 New temperature-dependent conformational transition in lysozyme

detected by carbon-13 nuclear magnetic resonance spectroscopy, 2095 Nuclear pore complex

Nuclear pore complexes associated with a lamina, 1007 Nuclear protein synthesis


Nuclease, S1 Mapping mutational alterations in DNA with S1 nuclease: Location of

deletions and temperature-sensitive mutations in simian virus 40, 989 Nucleic acid reassociation kinetics: Reactivity of single-stranded tails in

DNA-DNA renaturation, 4805 Nucleation

Structure and function of immunoglobulin domains: Studies with beta2-microglobulin on role of intrachain disulfide bond, 548

Nucleic acid, folding of Genome-sized RNA from reovirus particles, 4317

Nucleic acid hybridization Demonstration of non-functional /-globin mRNA in homozygous

f?-thalassemia, 5140 Histone gene arrangement in sea urchin Strongylocentrotus purpuratus,

4815 Infection of preimplantation mouse embryos and of newborn mice with




Strand-selective transcription of globin genes in rabbit erythroid cells and chromatin, 4835

Nucleic acid reassociation kinetics Nucleic acid reassociation kinetics: Reactivity of single-stranded tails in

DNA-DNA renaturation, 4805 Nucleic acid solvation

Theoretical studies of metal-phosphate interactions, 3794 Nucleic acid strands

Protein-free spreading of double- and single-stranded nucleic acid molecules, 83

Nucleohistone Chromatin architecture: Investigation of subunit of chromatin by dark

field electron microscopy, 2691 Nucleolar fusion


Nucleophilicity Iron-sulfur clusters: Ligand exchange kinetics studied on water-soluble

Fe4S4(SR)4n- cluster, 2478 Nucleoprotein unit


5'-Nucleotidase (EC 3.1.3.5) Immunological escape mechanism in spontaneously metastasizing

mammary tumors, 1012 Translocation of 5'-nucleotidase across hepatic membranes in vivo, 4013

Nucleotide pool Model for compartmentation of de novo and salvage thymidine

nucleotide pools in mammalian cells, 3333 Permeability lesions in male Escherichia coli infected with

bacteriophage T7, 2222 Nucleotide sequence

see Deoxyribonucleic acid nucleotide sequence; Ribonucleic acid nucleotide sequence

Nucleus, cell Viral and cellular DNA synthesis in nuclei from human lymphocytes

transformed by Epstein-Barr virus, 2413 nude mouse

see Mouse, athymic nude Nuisance parameter

Power of optimal asymptotic tests of composite statistical hypotheses, 577

Number theory Analysis of subtractive algorithm for greatest common divisors, 4720

Numerical existence property Disjunction property implies numerical existence property, 2877

Numerical method Point estimates for probability moments, 3812

Nutrient effect Conditions controlling commitment of differentiation in Bacillus

megaterium, 4037 Nutrition

Regulation of development in Myxococcus xanthus: Effect of 3':5'-cyclic AMP, ADP, and nutrition, 518

Nutritional response see also Diet; Feeding

Subject Index 43

General model for nutritional responses of higher organisms, 4327

Oat see Avena sativa

Oil-spill dispersal Chemoreceptors and feeding in calanoid copepods (Arthropoda:

Crustacea), 4185 Olfaction

Correlation of moth sex pheromone activities with molecular characteristics involved in conformers of bombykol and its derivatives, 3337

Oriental fruit fly, Dacus dorsalis, attracted to methyl eugenol and related olfactory stimulants, 2501

Oligo(adenosine diphosphate ribose) Macromolecular enzymatic product of NAD+ in liver mitochondria, 1436

Oligopeptide, end-to-end distance of Distribution of end-to-end distances of oligopeptide in solution

estimated by energy transfer, 1807 Oligosaccharide inhibition

Tumor-associated determinant(s) of carcinoembryonic antigen, 1528 Oncogenesis

see also Tumorigenicity Failure of human cells transformed by simian virus 40 to form tumors in

athymic nude mice, 4971 Oncornavirus

Inhibition of oncornavirus functions by 2'-azido polynucleotides, 284 Mapping of biological functions on RNA of avian tumor viruses:



Oncornavirus-like particle Oncornavirus-like particles from cultured bone marrow cells preceding

leukemia and malignant histiocytosis, 2804 Oncornavirus-like particles in human skin cancers, 3697 Oncornavirus-like particles released from arginine-deprived human

lymphoblastoid cell lines, 4592 Transformation of cultured human embryonic fibroblasts by


Viral-related information in oncornavirus-like particles isolated from cultures of marrow cells from leukemic patients in relapse and remission, 623

Oocytes, Xenopus laevis Induction of maturation (meiosis) in Xenopus laevis oocytes by three

organomercurials, 1574 Interferon activity produced by translation of human interferon


Operator Infinitesimal generators and quasi-units in potential theory, 2498 Intertwining operators and automorphic forms for the metaplectic group,

1406 Singular integrals and the principal series, IV, 2459 Spectra of convolution operators on Lp spaces, 3285 Variational formula for principal eigenvalue for operators with maximum

principle, 780 X and Y operators for general linear transport processes, 1210

Operon, arabinose Biochemical construction and selection of hybrid plasmids containing

specific segments of Escherichia coli genome, 4361 Operon, histidine



Regulation of histidine operon does not require hisG enzyme, 5021 Operon, lactose


Operon, leucine Biochemical construction and selection of hybrid plasmids containing

specific segments of Escherichia coli genome, 4361 Operon, tryptophan

Biochemical construction and selection of hybrid plasmids containing specific segments of Escherichia coli genome, 4361

Opiate Dual regulation of adenylate cyclase accounts for narcotic dependence

and tolerance, 3092 Kinetics of opiate receptor inactivation by sulfhydryl reagents: Evidence

for conformational change in presence of sodium ions, 2404 Opioid, endogenous

Failure of opiate antagonist naloxone to modify hypnotic analgesia, 2041 Optical diffraction


Optical energy conversion Photoassisted electrolysis of water by irradiation of a titanium dioxide

electrode, 1518 Optic tectum


Optimal asymptotic test Power of optimal asymptotic tests of composite statistical hypotheses,

577



44 Subject Index

Organelle evolution Heme biosynthesis in bacterium-protozoon symbioses: Enzymic defects



Prokaryotic nature of red algal chloroplasts, 2310 Orgaliomercurial

Induction of maturation (meiosis) in Xenopus laevis oocytes by three organomercurials, 1574

Organometallic molecule X-ray absorption spectroscopy using synchrotron radiation for structural

investigation of organometallic molecules of biological interest, 2340 Origin

National Science Foundation: Origins, hopes, and aspirations (Symposium), 2839

Origin of replication Bidirectional replication of piasmid R6K DNA in Escherichia coli:


T antigen binds to simian virus 40 DNA at the origin of replication, 1605 Ornithine decarboxylase (EC 4.1.1.17)

Cell cycle specific fluctuations in adenosine 3':5'-cyclic monophosphate and polyamines of Chinese hamster cells, 1482


Nature of increase in renal ornithine decarboxylase activity after cycloheximide administration in rat, 2279

Oryctolagus cuniculus Steroidogenesis in rabbit preimplantation embryos, 298

Oryza sativa Reversible redistribution of phytochrome within cell upon conversion to

physiologically active form, 799 Oscillation

Molecular mechanism for oscillation in flagella and muscle, 3102 Topological theorem for nonlinear dynamics in chemical and ecological

networks, 2856 Osmotic flow

General model for osmotic and pressure-induced flow in plant roots, 3114

Ossicle Formation of bone marrow in fibroblast-transformation ossicles, 2212

Osteogenesis imperfecta Abnormal collagen metabolism in cultured cells in osteogenesis

imperfecta, 586 Ouabain

Components of 02-uptake by excised frog nerve dependent upon externally supplied sodium ions, 3988


Ovary Ovary as a source of a-ecdysone in an adult mosquito, 3255 Physical characteristics of the gonadotropin receptor-hormone

complexes formed in vivo and in vitro, 1272 g-Oxo-bis[iron(III)tetraphenylporphyrin]

Resonance Raman effect in A-oxo-bis[iron(III)tetraphenylporphyrin], 4419

Oxygen Components of 02-uptake by excised frog nerve dependent upon

externally supplied sodium ions, 3988 Functional intermediates in reaction of cytochrome oxidase with oxygen,

1635 Oxygen and carbon monoxide binding to synthetic analogs of myoglobin

and hemoglobin active sites, 1166 Oxygen and cyclic nucleotides in human umbilical artery, 3883 Ozone model for bonding of 02 to heme in oxyhemoglobin, 2335 Reaction of tris(bipyridine)ruthenium(III) with hydroxide and its

application in a solar energy storage system, 2858 Oxygenation


Oxygen-pulse experiment Magnitude of subunit inequivalence for oxygen release from hemoglobin:

Reinvestigation of oxygen-pulse experiment, 3998 Oxytocin analog

Contribution of peptide backbone to the action of oxytocin analogs, 563 Ozone model

Ozone model for bonding of 02 to heme in oxyhemoglobin, 2335

Pachytene Electron microscopy of meiosis in Drosophila melanogaster females:

Recombination nodule-a recombination-associated structure at pachytene? 3186

Pain and distress, ischemic Failure of opiate antagonist naloxone to modify hypnotic analgesia, 2041

Palate Epithelial cell death and cyclic AMP increase during palatal

development, 874 Paleontology

Paleopleurocapsa wopfnerii gen. et sp. nou.: Late Precambrian alga and its modern counterpart, 2488

Theory of evolution above the species level, 646 Paleopleurocapsa wopfnerii

Paleopleurocapsa wopfnerii gen. et sp. nov.: Late Precambrian alga and its modern counterpart, 2488

Palindrome Site-specific recA-independent recombination between bacterial



Pancreas, endocrine Immunoreactive somatostatin is present in discrete cells of endocrine


pancreas (correction), 2833 Pancreatic juice

Amino-acid sequence of bovine carboxypeptidase B, 1666 Papain

Immunological and chemical purity of papain-solubilized HL-A antigens, 1594

Papillomavirus, human Human papillomavirus DNA: Physical map, 4810

Papovavirus genome Homology and relationship between genomes of papovaviruses, BK virus

and simian virus 40, 2563 Paramagnetic component

Interaction of ubisemiquinone with a paramagnetic component in heart tissue, 2886

Parasitism, intracellular Coenzyme A requirement of malaria parasites: Enzymes of coenzyme A

biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae, 2456

Parathormone see Parathyrin

Parathyrin Cytoplasmic and nuclear binding components for

la,25-dihydroxyvitamin D3 in chick parathyroid glands, 4871 Target cells in bone for parathormone and calcitonin are different:

Enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces, 3167

Parathyroid gland Cytoplasmic and nuclear binding components for

l1,25-dihydroxyvitamin D3 in chick parathyroid glands, 4871 Parathyroid hormone

see Parathyrin Pareto Law

Distributions associated with Bose-Einstein statistics, 1654 Particle, polarized

Source theory discussion of deep inelastic scattering with polarized particles, 1559

Particle (virus), defective interfering New Jersey serotype of vesicular stomatitis virus and its defective

particles, 1202 Partition function

Properties of molten magnesium oxide, 1026 Parvalbumin

Amino-acid sequence of parvalbumin from rabbit skeletal muscle, 1309 Pathology


C-type virus particles in placenta of normal healthy Sprague-Dawley rats, 3240

Isolation of a low-molecular-weight serum component antigenically related to an amyloid fibril protein of unknown origin, 1473

Penicillin Degradation of penicillin G to phenylacetylglycine by D-alanine

carboxypeptidase from Bacillus stearothermophilus, 3463 Distinct penicillin binding proteins involved in the division, elongation,

and shape of Escherichia coli K12, 2999 Mechanism of action of penicillin: Triggering of pneumococcal autolytic

enzyme by inhibitors of cell wall synthesis, 4162 Pepsin

Kinetics of action of pepsin on fluorescent peptide substrates, 3424 Peptide

see also Polypeptide; Protein Peptide analysis


Peptide backbone Contribution of peptide backbone to the action of oxytocin analogs, 563

Peptide bond synthesis Soluble protein identified that stimulates peptide bond synthesis, 4257

Peptide chain termination mutant Possible peptide chain termination mutants in thymidine kinase gene of

herpes simplex virus, 4081 Peptide, extension


Peptide fragment, biologically active Human pituitary growth hormone: Biologically active

hendekakaihekaton peptide fragment corresponding to amino-acid residues 15-125 in the hormone molecule, 3878

Peptide, retro-D- Contribution of peptide backbone to the action of oxytocin analogs, 563

Peptide separation Rapid and specific method for isolation of thiol-containing peptides from

large proteins by thiol-disulfide exchange on solid support, 3029 Peptide substrate

Kinetics of action of pepsin on fluorescent peptide substrates, 3424 Peptide synthesis

see also Protein synthesis Enzymes as reagents in peptide synthesis: Enzymatic removal of amine

protecting groups, 2193 Peptidyl transferase activity

Ribosomal protein essential for peptidyl transferase activity, 844




Periodic Toda problem Complete solution of periodic Toda problem, 2879

Permeability, junctional Structure of tight junctions in epithelia with different permeability, 4487

Permeability lesion Permeability lesions in male Escherichia coli infected with

bacteriophage T7, 2222 Peroxidase (EC 1.11.1.7)




pH High resolution 31P nuclear magnetic resonance studies of intact yeast

cells, 4966 Phage

see Bacteriophage Phagocytosis


Contact inhibition of phagocytosis in epithelial sheets: Alterations of cell surface properties induced by cell-cell contacts, 719

Monocytes rather than lymphocytes are the insulin-binding cells in preparations of human peripheral blood mononuclear leukocytes: Implications for studies of insulin-resistant states in man, 474

Removal of senescent cells by human macrophages in situ, 3521 Phaseolus vulgaris


Phase separation Antagonistic effect of an inhalation anesthetic and high pressure on


Phase transition Conjugated polyene fatty acids as membrane probes, 1649 Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by

concanavalin A, 4409 On some modified spherical models, 4723 Theory of the chain melting phase transition of aqueous phospholipid

dispersions, 3993 Phenothiazine

Dopamine receptor binding in corpus striatum of mammalian brain, 4655 Phenothiazine drugs: Structure-activity relationships explained by

conformation that mimics dopamine, 1899 Phentolamine


Phenylalanyl-transfer ribonucleic acid synthetase (EC 6.1.1.20) Phenylalanyl-tRNA synthetase from baker's yeast: Role of 3'-terminal

adenosine of tRNAPhe in enzyme-substrate interaction studied with 3'-modified tRNAPhe species, 1378

Phenylglyoxal Functional arginyl residues as ATP binding sites of glutamine synthetase

and carbamyl phosphate synthetase, 2616 Pheophytin, reduced


Pheromone Correlation of moth sex pheromone activities with molecular

characteristics involved in conformers of bombykol and its derivatives, 3337

Individual odor differences and their social functions in insects, 2824 Phosphatase

see Acid phosphatase; Alkaline phosphatase Phosphate complex

Theoretical studies of metal-phosphate interactions, 3794 Phosphatide

Isolation of Escherichia coli mutants defective in enzymes of membrane lipid synthesis, 2274

Phosphatidylcholine vesicle Headgroup conformation and lipid-cholesterol association in

phosphatidylcholine vesicles: 31P1lH} nuclear Overhauser effect, 3477 Phosphatidylethanolamine derivative

Stimulation and inhibition of anti-hapten responses in guinea pigs immunized with hybrid liposomes, 4582

Phosphatidylserine decarboxylase Biogenesis of membrane lipids: Mutants of Escherichia coli with

temperature-sensitive phosphatidylserine decarboxylase, 1112 Phosphodiesterase

see Adenosine 3':5'-cyclic monophosphate phosphodiesterase (EC 3.1.4.17); Endonuclease

Phosphoenolpyruvate:sugar phosphotransferase system Interaction of enzyme I of the phosphoenolpyruvate:sugar


Phosphofructokinase (EC 2.7.1.11) Control of oscillating glycolysis of yeast by stochastic, periodic, and

steady source of substrate: Model and experimental study, 3829 Electron microscope study of native and crosslinked rabbit muscle

phosphofructokinase, 3054 6-Phosphogluconate dehydrogenase (EC 1.1.1.44)


Phosphoglycerate kinase (EC 2.7.2.3) Human X-linked genes regionally mapped utilizing X-autosome

translocations and somatic cell hybrids, 2125

Subject Index 45

Phospholipid Biogenesis of membrane lipids: Mutants of Es,cherichia coli with

temperature-sensitive phosphatidylserine decarboxylase, 111'2 Headgroup conformation and lipid-cholesterol association in

phosphatidylcholine vesicles: 31p1lH} nuclear Overhauser effect, 3477 Mechanism of cytolysis by complement: Insertion of C5b and C7


Neutron diffraction studies on location of water in lecithin bilayer model membranes, 376

Preparation of large monodomain phospholipid bilayer smectic liquid crystals, 840

Theory of the chain melting phase transition of aqueous phospholipid dispersions, 3993

Phosphoprotein phosphatase (EC 3.1.3.16) Protein kinase and its regulatory effect on reverse transcriptase activity

of Rous sarcoma virus, 2945 Separation of "estrogen-induced" protein from phosphoprotein

phosphatase activity of immature rat uterus, 2631 Phosphorylase phosphatase (EC 3.1.3.17)


Phosphothreonine In vivo and in vitro phosphorylation of DNA-dependent RNA


Phosphotubulin Microtubule phosphorylation during cell cycle of HeLa cells, 1161

Photoaffinity labeling see also Affinity labeling Identification of a region in 23S rRNA located at peptidyl transferase

center, 4332 Photochemistry

Absence of interference in photoexcitation of triplets, 4203 Chemically induced dynamic electron polarization in chloroplasts at

room temperature: Triplet state participation in photosynthesis, 4943 Kinetics of binding of carbon monoxide to Lumbricus erythrocruorin: A

possible model, 4313 Picosecond detection of intermfediate in photochemical reaction of

bacterial photosynthesis, 2251 Photoentrainment

Circadian rhythm of neuron R15 of Aplysia californica: In vivo photoentrainment, 2408

Photoexcitation of triplets Absence of interference in photoexcitation of triplets, 4203

Photooxidation Photooxidation of chlorins by quinones studied by nuclear magnetic

resonance techniques, 3265 Photophosphorylation

Interaction of glyoxal and methylglyoxal with biogenic amines, 1610 Regulation of ferredoxin-catalyzed photosynthetic phosphorylations,

4961 Photoprotein

Chemical nature of bioluminescence systems in coelenterates, 1546 Renilla-type luciferin extracted from calcium-activated photoproteins

aequorin, mnemiopsin, and berovin, 2530 Photoreactivating enzyme



Photosensitive pigment Isorhodopsin: II. Artificial photosensitive pigment formed from

9,13-dicis retinal, 1538 Photosensitivity


Photosynthesis Biosynthesis of 3-aminolevulinic acid from intact carbon skeleton of

glutamic acid in greening barley, 2719 Chemically induced dynamic electron polarization in chloroplasts at

room temperature: Triplet state participation in photosynthesis, 4943 Regulation of ferredoxin-catalyzed photosynthetic phosphorylations,

4961 Stabilization of electron spin resonance probes for photosynthesis

studies, 3107 Photosynthesis, bacterial

Picosecond detection of intermediate in photochemical reaction of bacterial photosynthesis, 2251

Primary acceptor in bacterial photosynthesis: Obligatory role of ubiquinone in photoactive reaction centers of Rhodopseudomonas spheroides, 3491



Photosystem II reaction center Thylakoid membrane polypeptides of Chlamydomonas reinhardtii:


o-Phthalaldehyde o-Phthalaldehyde: Fluorogenic detection of primary amines in picomole

range: Comparison with fluorescamine and ninhydrin, 619 Phycology

Paleopleurocapsa wopfnerii gen. et sp. nov.: Late Precambrian alga and its modern counterpart, 2488

Phycomyces Meiosis in Phycomyces, 4076



46 Subject Index

Mutations affecting sexual development in Phycomyces blakesleeanus, 127

Physics Extraordinary dielectric properties of biological materials and action of

enzymes, 4211 Kinetic theory of viscosity of compressed fluids, 1970 On some modified spherical models, 4723 Pion spectrum in decay of i'(3.7) to 4(3.1), 4216 Possibility of a hydrodynamic model of the electron, 2037 Scanning transmission ion microscope with field ion source, 1826 Source theory analysis of electron-positron annihilation experiments,

4725 Source theory discussion of deep inelastic scattering with polarized

particles, 1559 Phytochrome

Reversible redistribution of phytochrome within cell upon conversion to physiologically active form, 799

Phytohemagglutinin see also Lectin; Lymphocyte stimulation Changes in ribosomal RNA processing paths in resting and

phytohemagglutinin-stimulated guinea pig lymphocytes, 3315 Chinese hamster ovary cells selected for resistance to cytotoxicity of

phytohemagglutinin are deficient in a UDP-N-acetylglucosamine-glycoprotein N-acetylglucosaminyltransferase activity, 3323



Separation of T cell subpopulations capable of DNA synthesis, lymphotoxin release, and regulation of antigen and phytohemagglutinin responses on basis of density and adherence properties, 5090


Phytopathology Differential activity staining: Use in characterization of guanylyl-specific

ribonuclease in genus Ustilago, 4914 Picornavirus

Complete translation of poliovirus RNA in a eukaryotic cell-free system, 4157

Picryl chloride Inhibition by interferon of delayed-type hypersensitivity in mouse, 1753

Pili, F Mating signal and DNA penetration deficiency in conjugation between

male Escherichia coli and minicells, 3721 Pineal gland, rat



Pion Pion spectrum in decay of 4'(3.7) to 1(3.1), 4216 Source theory analysis of electron-positron annihilation experiments,

4725 Pituitary factor


Pituitary, mouse Molecular weights of adrenocorticotropic hormone in extracts of anterior

and intermediate-posterior lobes of mouse pituitary, 3565 Placenta


Electron microscopic study of virus particles in rhesus monkey placenta, 118

Plancherel measure Theorem on the Schwartz space of a reductive Lie group, 4718

Plant hormone Satellite-rich DNA in cucumber: Hormonal enhancement of synthesis

and subcellular identification, 2260 Plant root

General model for osmotic and pressure-induced flow in plant roots, 3114

Plasma see also Serum

Plasma equilibrium Adiabatic evolution of plasma equilibrium, 3789

Plasma membrane see Membrane, plasma

Plasma protein Synthesis and differentiation of plasma proteins in cultured embryonic


Plasma, toroidal Computer simulation of toroidal equilibrium and stability of a plasma in

three dimensions, 926 Plasmacytoma

Cell-free translation of immunoglobulin messenger RNA from MOPC-315 plasmacytoma and MOPC-315 NR, variant synthesizing only light chain, 224

Distinct molecular structures of nuclear class I, II, and III deoxyribonucleic acid-dependent ribonucleic acid polymerases, 348

Plasmid see also Antibiotic resistance Cloning, isolation, and characterization of replication regions of complex

plasmid genomes, 2242



Inheritability of plasmids and population dynamics of cultured cells, 4085

Site-specific recA-independent recombination between bacterial plasmids: Involvement of palindromes at the recombinational loci, 1373

Plasmid, colicin El Replication of colicin El plasmid DNA added to cell extracts, 1050 Replicative intermediates of colicin El plasmid DNA in minicells, 829

Plasmid, hybrid, construction of Biochemical construction and selection of hybrid plasmids containing

specific segments of Escherichia coli genome, 4361 Plasmid interaction

Plasmid interactions in Staphylococcus aureus: Nonadditivity of compatible plasmid DNA pools, 5031

Plasmid, R Carcinogens as mutagens: Bacterial tester strains with R factor plasmids,

979 R-factor replication in presence of chloramphenicol, 654 Sulfonamide resistance mechanism in Escherichia coli: R plasmids can

determine sulfonamide-resistant dihydropteroate synthases, 2621 Transposition of R factor genes to bacteriophage X, 3628 Very stable prokaryotic messenger RNA in chromosomeless Escherichia

coli minicells, 2900 Plasmid, recombinant


Plasmid, tetracycline resistance Plasmid-determined tetracycline resistance in Streptococcus faecalis:

Gene amplification during growth with tetracycline, 1720 Plasmin, human

Plasmin digests of S-carbamidomethylated human growth hormone, 1684 Plasminogen activator

Correlated suppression by 5-bromodeoxyuridine of tumorigenicity and plasminogen activator in mouse melanoma cells, 47

Plasminogen structure Amino-acid sequence of activation cleavage site in plasminogen:

Homology with "pro" part of prothrombin, 2577 Plasmodium lophurae

Coenzyme A requirement of malaria parasites: Coenzyme A precursors affect extracellular development in vitro of Plasmodium lophurae, 1834


On primary structure and biosynthesis of histidine-rich polypeptide from malarial parasite Plasmodium lophurae, 3057

Platelet-aggregating factor Antibody nature of circulating inhibitor of plasma von Willebrand factor,

4167 Plate theory

Statistical theory of chromatography: New outlooks for affinity chromatography, 4840

Platinum Solar abundance of platinum, 4193

Platinum metallointercalation reagent X-ray fiber diffraction evidence for neighbor exclusion binding of

platinum metallointercalation reagent to DNA, 4825 Play

Play: Early and eternal, 1878 Point estimate

Point estimates for probability moments, 3812 Polarity, genetic

Regulation of histidine operon does not require hisG enzyme, 5021 Polar quenching

Collisional energy transfer and quenching of electronic excitation, 4205 Poliovirus ribonucleic acid


Pollution, stratospheric Estimates of stratospheric pollution by analytic model, 4711

Polyadenylate see also Ribonucleic acid, messenger, polyadenylylated; Ribonucleic acid,

polyadenylylated Absence of polyadenylate segment in globin messenger RNA accelerates

its degradation in Xenopus oocytes, 3065 Interaction of poly(A) and mRNA with eukaryotic initiator Met-tRNAf

binding factor: Activity on reticulocyte ribonucleic acid protein particles, 1021

In vitro addition of polyadenylate sequence to 3' end of phage Q/3 RNA and biological activity of product, 428

Nuclear and cytoplasmic poly(adenylic acid), 3580 Poly(adenylic acid) sequences in the RNA of Caulobacter crescentus,

2343 Poly(A) shortening and mRNA turnover, 1077 Presence of polyriboadenylate sequences in pulse-labeled RNA of

Escherichia coli, 2910 Short-lived messenger RNA in HeLa cells and its impact on kinetics of

accumulation of cytoplasmic polyadenylate, 389 Translation of RNA that contains polyadenylate from yeast

mitochondria in Escherichia coli ribosomal system, 4293 Two classes of translational control RNA: Their role in the regulation of

protein synthesis, 1523 Polyamine

Cell cycle specific fluctuations in adenosine 3':5'-cyclic monophosphate and polyamines of Chinese hamster cells, 1482




Poly(deoxyadenylate-deoxythymidylate) De novo synthesis of polymer of deoxyadenylate and deoxythymidylate

by calf thymus DNA polymerase a, 3944 Poly(ethylene oxide)

DNA condensates induced by poly(ethylene oxide) and polylysine, 4288 Polylysine

DNA condensates induced by poly(ethylene oxide) and polylysine, 4288 Visualization of actin fibers associated with cell membrane in amoebae of

Dictyostelium discoideum, 1758 Polynomial, recursively defined

Limits of zeroes of recursively defined polynomials, 4209 Polynucleotide

see also Deoxyribonucleic acid; Ribonucleic acid Polynucleotide, 2'-azido

Inhibition of oncornavirus functions by 2'-azido polynucleotides, 284 Polynucleotide ligase

Action of nicking-closing enzyme on supercoiled and nonsupercoiled closed circular DNA: Formation of Boltzmann distribution of topological isomers, 4280

Conformational fluctuations of DNA helix, 4275 Polynucleotide, single-stranded

Use of gene 32 protein staining of single-strand polynucleotides for gene mapping by electron microscopy: Application to 80d3ilvsu+ system, 4506

Polynucleotide synthetase (ATP) (EC 6.5.1.1) Genetic evidence for an additional function of phage T4 gene 32 protein:

Interaction with ligase, 1226 Polynucleotide synthetase (NAD+)

Induction of error-prone repair as consequence of DNA ligase deficiency in Escherichia coli, 4645

Polynucleotide synthetase (NAD+) (EC 6.5.1.2) Genetic evidence for an additional function of phage T4 gene 32 protein:

Interaction with ligase, 1226 Polyoma virus

Hamster a-amanitine-resistant RNA polymerase II able to transcribe polyoma virus genome in somatic cell hybrids, 753


Transformation by polyoma virus alters expression of cell mutation affecting cycle traverse, 2540

Polypeptide see also Peptide; Protein

Polypeptide chain initiation see also Initiation factor; Protein synthesis How ribosomes select initiator regions in mRNA: Base pair formation

between 3' terminus of 16S rRNA and mRNA during initiation of protein synthesis in Escherichia coli, 4734

Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: Indirect mode of action on polypeptide chain initiation, 1286

Polypeptide chain termination and initiation An intercistronic region and ribosome-binding site in bacterial messenger

RNA, 2399 Polypeptide, viral


Polyphosphate High resolution 31p nuclear magnetic resonance studies of intact yeast

cells, 4966 Polyploidy

Proposal concerning mechanism of evolution of the genome of Escherichia coli, 1354

Polyprotein Complete translation of poliovirus RNA in a eukaryotic cell-free system,

4157 Polysaccharide conformation


Polysome, brain d-Amphetamine disaggregates brain polysomes via a dopaminergic

mechanism, 834 Polysphondylium violaceum

Genetic complexity of aggregation in cellular slime mold Polysphondylium violaceum, 1041

Poly(L-valine), high-molecular-weight Conformation of high-molecular-weight poly(L-valine) in solid state, 941

Population dynamics Inheritability of plasmids and population dynamics of cultured cells,

4085 Population genetics

see Genetics, population Population, mammalian

Social structuring of mammalian populations and rate of chromosomal evolution, 5061

Porphyria Porphyria variegata and porphyria cutanea tarda in siblings: Chemical

and genetic aspects, 5126 Porphyrin

Biosynthesis of 1-aminolevulinic acid from intact carbon skeleton of glutamic acid in greening barley, 2719

Resonance Raman effect in ,-oxo-bis[iron(III)tetraphenylporphyrin], 4419

Resonance Raman spectra of manganese(III) tetraphenylporphin halides, 433

Positron Source theory analysis of electron-positron annihilation experiments,

4725

Subject Index 47

Potassium transport Serum rapidly stimulates ouabain-sensitive s6Rb+ influx in quiescent

3T3 cells, 4492 Potential energy function, empirical


Potential function Well-posed inverse spectral problems, 2496

Potential, postsynaptic Molecular model of postsynaptic potential, 1749

Potential theory Infinitesimal generators and quasi-units in potential theory, 2498

Power Power of optimal asymptotic tests of composite statistical hypotheses,

577 Prediction algorithm, three-dimensional


Prednisone Lymphocyte cytotoxicity to autologous liver cells in chronic active

hepatitis, 1301 Pre-proinsulin

Translation of messenger ribonucleic acid from isolated pancreatic islets and human insulinomas, 4777

Presodium current Effects of tetraalkylammonium salts on Brdicka and presodium currents

of bovine-serum albumin, 2863 Presynaptic action

Presynaptic action of barbiturates in frog spinal cord, 1460 Presynaptic events


Primary afferent Presynaptic action of barbiturates in frog spinal cord, 1460

Primate see also Baboon Evolution of human longevity and genetic complexity governing aging

rate, 4664 Isolation from Asian mouse Mus caroli of endogenous type C virus

related to infectious primate type C viruses, 2315 Play: Early and eternal, 1878

Primer-template Ability of tryptophan tRNA to hybridize with 35S RNA of avian

myeloblastosis virus and to prime reverse transcription in vitro, 2155 Principal series

Singular integrals and the principal series, IV, 2459 Probability moment

Point estimates for probability moments, 3812 Procarboxypeptidase A

Dissociation of bovine 6S procarboxypeptidase A by reversible condensation with 2,3-dimethyl maleic anhydride: Application to partial characterization of subunit III, 2442

Procollagen see also Collagen Interchain disulfide bonds in procollagen are located in large

nontriple-helical COOH-terminal domain, 3009 Procollagen: Biological scission of amino and carboxyl extension

peptides, 4905 Progesterone

ATP binding to progesterone receptor, 901 Proline catabolism

Regulation of proline catabolism by leucyl,phenylalanyl-tRNA-protein transferase, 405

Proline oxidase Role of epithelial architecture and intracellular metabolism in proline

uptake and transtubular reclamation in PRO/Re mouse kidney, 1431 Proline uptake

Role of epithelial architecture and intracellular metabolism in proline uptake and transtubular reclamation in PRO/Re mouse kidney, 1431

Promoter Initiation of in vitro mRNA synthesis from wild-type lac promoter, 4394 Nucleotide sequence of RNA polymerase binding site from DNA of

bacteriophage fd, 737 Nucleotide sequence of RNA polymerase binding site from DNA of

bacteriophage fd (correction), 2468 Promoter-dependent transcription of tRNAiTYr genes using DNA

fragments produced by restriction enzymes, 4754 Propagation function

Pion spectrum in decay of ,'(3.7) to 4(3.1), 4216 Properdin

Properdin: Initiation of alternative complement pathway, 3220 Prophage X

Excision of prophage X in cell-free system, 2188 Mutants of T7 bacteriophage inhibited by lambda prophage, 3642

PRO/Re mouse kidney Role of epithelial architecture and intracellular metabolism in proline

uptake and transtubular reclamation in PRO/Re mouse kidney, 1431 Prostaglandin

Antigen-stimulated changes in cyclic nucleotide levels in mouse, 2320 Estrogen-directed synthesis of specific prostaglandins in uterus, 1420 Human synoviocytes: Activation and desensitization by prostaglandins

and l-epinephrine, 3124 Mechanism and modification of bradykinin-induced coronary

vasodilation, 2060 Physiological role of an endoperoxide in human platelets: Hemostatic

defect due to platelet cyclo-oxygenase deficiency, 1446



48 Subject Index


Subversion of immune system by tumor cells and role of prostaglandins, 1848

Prostaglandin E2 Increased concentrations of nonesterified arachidonic acid,


Prostaglandin endoperoxide Physiological role of an endoperoxide in human platelets: Hemostatic

defect due to platelet cyclo-oxygenase deficiency, 1446 Synthesis and biological properties of 9,11-azo-prostanoid: Highly active

biochemical mimic of prostaglandin endoperoxides, 3355 Thromboxanes: A new group of biologically active compounds derived

from prostaglandin endoperoxides, 2994 Prostaglandin E1 receptor

Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma cells, 3472

Prostaglandin F2a Increased concentrations of nonesterified arachidonic acid,


Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2, 2724

Prostaglandin synthase (cyclo-oxygenase) (EC 1.14.99.1) Acetylation of prostaglandin synthase by aspirin, 3073

Prostanoid, 9,11-azo- Synthesis and biological properties of 9,11-azo-prostanoid: Highly active

biochemical mimic of prostaglandin endoperoxides, 3355 Prostate


Protamine New histones found in mature mammalian testes, 2714 Three-dimensional structure of herring sperm protamine Y-I with aid of

dark field electron microscopy, 4953 Protamine kinase (EC 2.7.1.70)

see also Protein kinase Translocation of heart cAMP-dependent protein kinase, 1501

Protease see also specific proteases; Proteolysis Bovine factor X1 (Stuart factor): Amino-acid sequence of heavy chain,

3082 Control of the synthesis of a single enzyme by multiple regulatory

circuits in Neurospora crassa, 1240 Homologous relationship between thermolysin and neutral protease A of

Bacillus subtilis, 4341 Molecular orbital studies of enzyme activity: Charge relay system and

tetrahedral intermediate in acylation of serine proteinases, 2606 Surface proteins in cell proliferation as studied with thrombin and other

proteases, 413 Protein

see also specific proteins; Peptide; Polypeptide Protein adenylylation


Protein aggregation Electron microscope study of native and crosslinked rabbit muscle

phosphofructokinase, 3054 Hemoglobin interaction in sickle cell fibers: Theoretical approaches to

molecular contacts, 1330 Protein, binding

see also specific compounds bound; Ligand; Receptor; Transport Binding protein-independent substrate translocation by

methylgalactoside i r.iii-Ip'ri .- --iii of Escherichia coli K12, 423 Competent Bacillus I; I ' L ii nl r(-e synthesize denatured DNA binding

activity, 323 /-D-Galactoside binding protein from electric organ tissue of

Electrophorus electricus, 1383 Distinct penicillin binding proteins involved in the division, elongation,

and shape of Escherichia coli K12, 2999 Folate binding factor in normal umbilical cord serum purified, 4261 Interaction of poly(A) and mRNA with eukaryotic initiator Met-tRNAf





Model for regulation of Escherichia coli DNA repair functions, 2330 Novel, low-molecular-weight DNA-binding protein from Escherichia

coli, 3428 Role of leucyl-tRNA synthetase in regulation of branched-chain

amino-acid transport, 3921 Significance of retention of ligand by protein, 2120

Protein, cholinergic receptor Regulation of binding properties of nicotinic receptor protein by


Spin-labeled long chain acylcholine interacts with cholinergic acceptor protein in membrane environment, 1087

Protein, coat Asymmetric orientation of phage coat protein in cytoplasmic membrane

of Escherichia coli, 4749


Protein conformation see also Conformational change Activation volumes in enzymic catalysis: Their sources and modification

by low-molecular-weight solutes, 3014 Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase

A: Monitor of multiple conformational states in solution, 4356 Molecular basis of /-galactosidase a-complementation, 1254 New temperature-dependent conformational transition in lysozyme

detected by carbon-13 nuclear magnetic resonance spectroscopy, 2095 Protein hydration changes during catalysis: Mechanism of enzymic

rate-enhancement and ion activation/inhibition of catalysis, 3305 Protein, contractile

Effects of cytochalasin B and colcemide on myogenic cultures, 513 Major nonhistone proteins of rat liver chromatin: Preliminary

identification of myosin, actin, tubulin, and tropomyosin, 3902 Protein denaturation

Apoprotein stability and lipid-protein interactions in human plasma high density lipoproteins, 4940

Protein folding Model of protein folding: Inclusion of short-, medium-, and long-range

interactions, 3802 Structure and function of immunoglobulin domains: Studies with

beta2-microglobulin on role of intrachain disulfide bond, 548 Protein, high-molecular-weight


Protein homology see also Amino acid sequence; Protein structure Amino-acid sequence of bovine carboxypeptidase B, 1666 Amino-acid sequence of parvalbumin from rabbit skeletal muscle, 1309 Bovine factor X1 (Stuart factor): Amino-acid sequence of heavy chain,

3082 Dissociation of bovine 6S procarboxypeptidase A by reversible


Evolutionary relationship between immunoglobulins and transplantation antigens, 1612


Homologous relationship between thermolysin and neutral protease A of Bacillus subtilis, 4341

Homology in amino-terminal sequence of precursors to pancreatic secretory proteins, 5016

Partial amino-acid sequence of NAD-specific glutamate dehydrogenase of Neurospora crassa, 4891

Similarities among hypervariable segments of immunoglobulin chains, 5107

Structural similarities between a product of the T/t-locus isolated from sperm and teratoma cells, and H-2 antigens isolated from splenocytes, 3215

Structure and regulation of immunoglobulins: Kappa allotypes in rat have multiple amino-acid differences in constant region, 5046

Tyrosine peptide homologies in the HLA antigen system, 5081 Protein hydration

Protein-water interaction studied by solvent 1H, 2H, and 170 magnetic relaxation, 2667

Protein interaction Electron microscope study of native and crosslinked rabbit muscle

phosphofructokinase, 3054 Hemoglobin interaction in sickle cell fibers: Theoretical approaches to

molecular contacts, 1330 Protein, iron-sulfur, high potential

Acid-base properties, hydrolytic mechanism, and susceptibility to 02 oxidation of Fe4S4(SR)4-2 clusters, 231

Interaction of ubisemiquinone with a paramagnetic component in heart tissue, 2886

NH--..S Hydrogen bonds in Peptococcus aerogenes ferredoxin, Clostridium pasteurianum rubredoxin, and Chromatium high potential iron protein, 4854

Synthetic analogs of active sites of iron-sulfur proteins: Bis(o-xylyldithiolato)ferrate(III) monoanion, a structurally unconstrained model for rubredoxin Fe-S4 unit, 2868

Protein kinase see also Protamine kinase (EC 2.7.1.70) Association of cyclic AMP-dependent protein kinase with purified


Protein kinase (EC 2.7.1.37) Changes in relative levels of guanosine-3':5'-monophosphate-dependent



In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase, 2506


Microtubule phosphorylation during cell cycle of HeLa cells, 1161 Protein kinase activation as early event in trans-synaptic induction of

tyrosine 3-monooxygenase in adrenal medulla, 1152 Protein kinase and its regulatory effect on reverse transcriptase activity

of Rous sarcoma virus, 2945 Structural gene mutation affecting the regulatory subunit of cyclic

AMP-dependent protein kinase in mouse lymphoma cells, 5051 Substrate specificity of cyclic AMP-dependent protein kinase, 3448

Protein matrix Dynamics of protein matrix revealed by fluorescence quenching, 3290




Protein, membrane Amino-acid sequence and oligosaccharide attachment sites of human

erythrocyte glycophorin, 2964 Crosslinking and labeling of membrane proteins by

transglutaminase-catalyzed reactions, 2568 Methylation of a membrane protein involved in bacterial chemotaxis,

3939 Translocation of 5'-nucleotidase across hepatic membranes in vivo, 4013 Very stable prokaryotic messenger RNA in chromosomeless Escherichia

coli minicells, 2900 Protein, mitogenic


Protein modification Procollagen: Biological scission of amino and carboxyl extension

peptides, 4905 Protein, nonhistone

Effect of chromosomal proteins extractable with low concentrations of NaCl on chromatin structure of resting and proliferating cells, 2361


Protein, nuclear acidic Estradiol-17,/ affects synthesis of specific uterine nonhistone

chromosomal proteins, 4346 Protein polymorphism

see also Allozyme; Genetic polymorphism Statistical analyses of Drosophila and human protein polymorphisms,

3194 Temporal fluctuation of selection coefficient affects gene frequency in a

population, 4541 Protein, regulatory


Protein, ribosomal Architecture of Escherichia coli ribosome as determined by immune

electron microscopy, 4820 Binding of ribosomal protein S1 of Escherichia coli to the 3' end of 16S

rRNA, 2940 Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal

RNA, and RNA polymerase subunits, 2743 Isolation and characterization of two acidic proteins of 60S ribosomes

from Artemia salina cysts, 4744 Neutron scattering measurements of separation and shape of proteins in

30S ribosomal subunit of Escherichia coli: S2-S5, S5-S8, S3-S7, 3888 Ribosomal protein essential for peptidyl transferase activity, 844 Ribosomal protein S1 and polypeptide chain initiation in bacteria, 2325

Protein secretion Homology in amino-terminal sequence of precursors to pancreatic

secretory proteins, 5016 Protein sequence

see Amino acid sequence Protein shedding

Titration of sodium channels in canine gastric mucosa, 3731 Protein, structural


Protein structure see also specific proteins; Amino acid sequence; Immunoglobulin

structure; Protein homology Assessment of some problems associated with prediction of


Crystal structure of human erythrocyte carbonic anhydrase B: Three-dimensional structure at nominal 2.2-A resolutioni, 51

Determination of iron-sulfur distances in rubredoxin by x-ray absorption spectroscopy, 4003


Structural properties of pyruvate carboxylases from chicken liver and other sources, 4308

Structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution, 38

Tertiary structure of myohemerythrin at low resolution, 2160 Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A

resolution, 2305 Three-dimensional structure of herring sperm protamine Y-I with aid of

dark field electron microscopy, 4953 Transition dipole coupling in Amide I modes of /3 polypeptides, 4933

Protein subunit composition Reconstitution of Escherichia coli pyruvate dehydrogenase complex,

3068 Protein, sweet

Crystallization and crystal data of monellin, 398 Protein synthesis

see also specific proteins; Elongation factor; Initiation factor; Peptide synthesis; Polypeptide chain initiation; Translation of genetic information


Cell-free synthesis of human interferon, 3898 Cellular protein synthesis required in reversal of



Content of elongation factor Tu in Escherichia coli, 4780

Subject Index 49

How ribosomes select initiator regions in mRNA: Base pair formation between 3' terminus of 16S rRNA and mRNA during initiation of protein synthesis in Escherichia coli, 4734

Hypoxanthine phosphoribosyltransferase deficiency: Association of reduced catalytic activity with reduced levels of immunologically detectable enzyme protein, 4142



On alleged high sensitivity of mouse Ehrlich-Lettre ascites tumor cells to diphtheria toxin, 3149

Parallel changes in puffing activity and patterns of protein synthesis in salivary glands of Drosophila, 3604


Regulation of synthesis of hepatic fatty acid synthetase: Polysomal translation in cell-free system, 4366

Relationship of first step in protein synthesis to ppGpp: Formation of A(5')ppp(5')Gpp, 2653


Soluble protein identified that stimulates peptide bond synthesis, 4257 Specialized transducing phages for ribosomal protein genes of

Escherichia coli, 6 Protein synthesis and memory


Protein synthesis, inhibition Inhibition of protein synthesis in rabbit reticulocyte lysates by



NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin, 2284

Protein synthesis, initiation Affinity labeling of the ribosomal decoding site with an AUG-substrate

analog, 1505 Binding of ribosomal protein S1 of Escherichia coli to the 3' end of 16S

rRNA, 2940 Polypeptide chain initiation in eukaryotes: Initiation factor MP in

Artemia salina embryos, 3947 Regulation of protein synthesis at translational level in neuroblastoma

cells, 2289 Ribosomal protein S1 and polypeptide chain initiation in bacteria, 2325 Selective blockage of initiation of host protein synthesis in

RNA-virus-infected cells, 1258 Very rapid effect of androgen on initiation of protein synthesis in

prostate, 706 Protein synthesis in vitro

Biosynthesis of polypeptides of cytochrome c oxidase by isolated mitochondria, 172

Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal RNA, and RNA polymerase subunits, 2743

Control of mRNA for hepatic tryptophan oxygenase during hormonal and substrate induction, 1017

Coupled in vitro transcription and translation of vesicular stomatitis virus messenger RNA, 2545

Effects of bacteriophage T4-induced modification of Escherichia coli RNA polymerase on gene expression in vitro, 4928

Functional level of rat liver tryptophan 2,3-dioxygenase messenger RNA during superinduction of enzyme with actinomycin D, 4285


Interferon activity produced by translation of human interferon messenger RNA in cell-free ribosomal systems and in Xenopus oocytes, 4881



(Oligo)peptidyl-tRNA released from ribosomes by erythromycin A, 2649 Regulation of synthesis of hepatic fatty acid synthetase: Polysomal

translation in cell-free system, 4366 Replication of colicin El plasmid DNA added to cell extracts, 1050 Repression and autogenous stimulation in vitro by bacteriophage lambda

repressor, 804 Simian virus 40 DNA directs synthesis of authentic viral polypeptides in

linked transcription-translation cell-free system, 1922 Synthesis of specific functional messenger RNA in vitro by

phage-SPOl-modified RNA polymerase of Bacillus subtilis, 4886 Protein synthesis, regulation

Association of cyclic AMP-dependent protein kinase with purified translational inhibitor isolated from hemin-deficient rabbit reticulocyte lysates, 4849

Control of the synthesis of a single enzyme by multiple regulatory circuits in Neurospora crassa, 1240

Metabolites influence control of lysine transfer ribonucleic acid synthetase formation in Escherichia coli K-12, 1364

Regulation of protein synthesis at translational level in neuroblastoma cells, 2289


Synthesis and differentiation of plasma proteins in cultured embryonic



50 Subject Index


Two classes of translational control RNA: Their role in the regulation of protein synthesis, 1523

Protein variation, neutral Statistical analyses of Drosophila and human protein polymorphisms,

3194 Protein-water interaction


Protein-water interaction studied by solvent 1H, and .70 magnetic relaxation, 2667

Protein, zinc Zinc protein isolated from human parotid saliva, 488

Proteoglycan Carbon-13 nuclear magnetic resonance study of chondroitin 4-sulfate in

proteoglycan of bovine nasal cartilage, 3421 Proteolysis

see also Protease Complete translation of poliovirus RNA in a eukaryotic cell-free system,

4157 Hypoxanthine phosphoribosyltransferase deficiency: Association of


Imbalanced globin chain synthesis in heterozygous /-thalassemic bone marrow, 3853


Prothrombin Amino-acid sequence of activation cleavage site in plasminogen:

Homology with "pro" part of prothrombin, 2577 Mitogenic activity of blood components: I. Thrombin and prothrombin,

131 Protocoproporphyria

Porphyria variegata and porphyria cutanea tarda in siblings: Chemical and genetic aspects, 5126

Protomer Structural properties of pyruvate carboxylases from chicken liver and

other sources, 4308 Proton gradient

Cycle of deprotonation and reprotonation energizing amino-acid transport? 23

Protozoan see Plasmodium; Tetrahymena

Provirus Murine leukemia virus: Detection of unintegrated double-stranded DNA

forms of the provirus, 447 Pseudoconformal geometry

Pseudoconformal geometry of hypersurfaces in C+1', 2433 Pseudomonas phaseolicola

Intermediates in biosynthesis of double-stranded ribonucleic acids of bacteriophage 06, 849

Pseudomonas putida Autogenous regulation of inducible tryptophan synthase of Pseudomonas

putida, 1249 Psoriasis


Psychology Control of meal size by central noradrenergic action, 3740 Effect of acetoxycycloheximide on rate of accumulation of cerebral




Play: Early and eternal, 1878 Somnolence, akinesia, and sensory activation of motivated behavior in

lateral hypothalamic syndrome, 2819 Pterin, 6-methyltetrahydro-


Puberty Body weight and food intake at early estrus of rats on high-fat diet, 4172

Pulsar Progress and prospects in high energy astrophysics, 4685

Purification see Methodology (purification and preparation)

Purine Purine metabolism in murine virus-induced erythroleukemic cells during

differentiation in vitro, 1630 Puromycin



Photoincorporation of puromycin and N-(ethyl-2-diazomalonyl)puromycin into Escherichia coli ribosomes, 2974

Pyran-Sepharose Affinity chromatography of viral DNA polymerases on pyran-Sepharose,

1142 Pyridoxal phosphate

Beta-cyanoalanine synthase: Purification and characterization, 1617 Pyrimidine '

Anticytokinin activity of substituted pyrrolo[2,3-d]pyrimidines, 3508




5'-5' Pyrophosphate bond Synthesis of RNA containing a methylated blocked 5' terminus by HeLa

nuclear homogenates, 2930 Pyrrolidine ring puckering


Pyrrolo[2,3-d]pyrimidine, substituted Anticytokinin activity of substituted pyrrolo[2,3-d]pyrimidines, 3508

Pyruvate carboxylase (EC 6.4.1.1) Structural properties of pyruvate carboxylases from chicken liver and

other sources, 4308 Pyruvate dehydrogenase complex (EC 1.2.4.1)

Reconstitution of Escherichia coli pyruvate dehydrogenase complex, 3068

Quantum yield Bacterial luciferase requires one reduced flavin for light emission, 3374

Quasar Chronometric cosmology: Preliminaries and redshift-magnitude relation,

2473 Progress and prospects in high energy astrophysics, 4685

Quenching of electronic excitation Collisional energy transfer and quenching of electronic excitation, 4205

Quinacrine fluorescence Nonrandom chromosomal abnormalities in hematologic disorders of

man, 152 Quinate catabolism


Quinone Photooxidation of chlorins by quinones studied by nuclear magnetic

resonance techniques, 3265

Rn Inequalities in Fourier analysis on Rn, 638

Rabbit see Oryctolagus cuniculus

Racemization dating Aspartic acid racemization in tooth enamel from living humans, 2891

Radar ornithology Reactions of migrating birds to lights and aircraft, 1994

Radiation, ionizing see also X-irradiation Endonucleolytic incision of x-irradiated deoxyribonucleic acid by

extracts of Escherichia coli, 1997 X-ray absorption spectroscopy using synchrotron radiation for structural

investigation of organometallic molecules of biological interest, 2340 Radiation leukemia virus

In vitro infection of lymphoid cells by thymotropic radiation leukemia virus growp in vitro, 3546

Radical pair Chemically induced dynamic electron polarization in chloroplasts at

room temperature: Triplet state participation in photosynthesis, 4943 Radio galaxy

Progress and prospects in high energy astrophysics, 4685 Radioimmunoassay

Carcinoembryonic antigen: Evidence for multiple antigenic determinants and isoantigens, 4602

Measurement of human dopamine-,B-hydroxylase in serum by homologous radioimmunoassay, 750


Radius, covalent Maximum-valence radii of transition metals, 3799

Radon-228 chronology Slow growth rate of deep-sea clam determined by 228Ra chronology, 2829

Raman spectroscopy see also Resonance Raman spectroscopy Resonance Raman spectra of manganese(III) tetraphenylporphin halides,

433 Resonance Raman spectroscopic studies of interactions between trypsin

and competitive inhibitor, 4223 Rana catesbeiana


Rat Body weight and food intake at early estrus of rats on high-fat diet, 4172 C-type virus particles in placenta of normal healthy Sprague-Dawley

rats,, 3240 Salmonella mutants associated with germfree rats: Site specific model to

detect carcinogens as mutagens, 4607 Rate process

Rate processes and compensation rule, 999 Rate theory






Real manifolds, complexifications of Complexifications of real manifolds, 4210

recBC enzyme DNA synthesis involving a complexed form of DNA polymerase I in

extracts of Escherichia coli, 2099 Receptive field, development


Receptor see also specific compounds; Protein, binding

Receptor, acetylcholine see also Receptor, cholinergic Acetylcholine-receptor-mediated ion flux in electroplax membrane

preparations, 4371 Acetylcholine receptors at neuromuscular synapses: Phylogenetic

differences detected by snake a-neurotoxins, 3245 Cholinergic synapses formed between dissociated sympathetic neurons

and skeletal myotubes of rat in cell culture, 1955 Immunological relationship between acetylcholine receptor and thymus:

A possible significance in myasthenia gravis, 1456 Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma

cells, 3472 Relaxation measurements on acetylcholine receptor, 3496 Synthesis of acetylcholine receptor by denervated rat diaphragm muscle,

1368 Synthesis of acetylcholine receptor during differentiation of cultured

embryonic muscle cells, 4028 Receptor, /B-adrenergic



Identification of cardiac /-adrenergic receptors by (-) [3H]alprenolol binding, 1564


Receptor, -y-aminobutyric acid Presynaptic action of barbiturates in frog spinal cord, 1460

Receptor, brain Brain receptors for antipsychotic drugs and dopamine: Direct binding

assays, 4376 Receptor, cell surface

Differentiation of peripheral blood lymphocytes into cells bearing sheep erythrocyte receptors in vitro by human thymic extract, 1175



Receptor, cholera toxin Mobility of cholera toxin receptors on rat lymphocyte membranes, 3844

Receptor, cholinergic see also Receptor, acetylcholine Regulation of binding properties of nicotinic receptor protein by


Spin-labeled long chain acylcholine interacts with cholinergic acceptor protein in membrane environment, 1087

Receptor, concanavalin A Concanavalin A receptors on surface membrane of lymphocytes from

patients with Hodgkin's disease and other malignant lymphomas, 1046 Receptor, dihydrotestosterone


Receptor, dopamine d-Amphetamine disaggregates brain polysomes via a dopaminergic

mechanism, 834 Dopamine receptor binding in corpus striatum of mammalian brain, 4655

Receptor, drug Brain receptors for antipsychotic drugs and dopamine: Direct binding

assays, 4376 Dual regulation of adenylate cyclase accounts for narcotic dependence


for conformational change in presence of sodium ions, 2404 Lack of detectable change in cyclic AMP during cardiac iriotropic

response to isoproterenol immobilized on glass beads, 824 Morphine receptors as regulators of adenylate cyclase activity, 590

Receptor, estrogen Estradiol-17/ affects synthesis of specific uterine nonhistone

chromosomal proteins, 4346 Receptor, glucagon

Mechanism of action of cholera toxin and mobile receptor theory of hormone receptor-adenylate cyclase interactions, 33

Receptor, glucocorticoid Effect of chemical inactivating agents on glucocorticoid receptor proteins

in mouse and hamster cells, 3060 Partial purification of glucocorticoid receptor, 3849

Receptor, gonadotropin Physical characteristics of the gonadotropin receptor-hormone

complexes formed in vivo and in vitro, 1272 Receptor, hormone

Cytoplasmic and nuclear binding components for 1a,25-dihydroxyvitamin D3 in chick parathyroid glands, 4871

Mechanism of action of cholera toxin and mobile receptor theory of hormone receptor-adenylate cyclase interactions, 33

Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats, 4033

Subject Index 51

Thyroid hormone binding by component of mitochondrial membrane, 3225

Receptor, insulin Ultrastructural localization of insulin receptors on adipocytes, 3526

Receptor, lymphocyte Modulation of lymphocyte receptor mobility by locally bound

concanavalin A, 1579 Thymus-derived rat lymphocyte receptor for cell surface antigens is


Receptor mobility Modulation of lymphocyte receptor mobility by locally bound

concanavalin A, 1579 Receptor, monocyte

Localization of IgG effector site for monocyte receptors, 2081 Receptor, morphine

Morphine receptors as regulators of adenylate cyclase activity, 590 Receptor, nicotinic

Regulation of binding properties of nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata, 3443

Receptor, opiate Dual regulation of adenylate cyclase accounts for narcotic dependence


for conformational change in presence of sodium ions, 2404 Receptor, progesterone

ATP binding to progesterone receptor, 901 Receptor, prostaglandin

Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma cells, 3472

Receptor, steroid Androgen- and estrogen-binding macromolecules in developing mouse

brain: Biochemical and genetic evidence, 4303 Receptor synapse

Receptor synapses without synaptic ribbons in cat cochlea, 3599 Recombination, genetic

see also Gene, recA Acquisition of determinant for chloramphenicol resistance by coliphage

lambda, 5041 Genetic evidence for an additional function of phage T4 gene 32 protein:

Interaction with ligase, 1226 Initiation of genetic recombination, 3619 Integrative recombination of bacteriophage lambda DNA in vitro, 1072 Mechanism to activate branch migration between homologous DNA

molecules in genetic recombination, 279 Model for genetic recombination, 358 Novel mutants of Escherichia coli that accumulate very small DNA

replicative intermediates, 2150 Site-specific recA-independent recombination between bacterial


Uptake of homologous single-stranded fragments by superhelical DNA: Possible mechanism for initiation of genetic recombination, 2394

Visualization of novel junction in bacteriophage X DNA, 3024 Recombination nodule

Electron microscopic observations on meiotic karyotype of diploid and tetraploid Saccharomyces cerevisiae, 5056


Recombination, nonhomologous Fusion of Escherichia coli lac genes to ara promoter: Bacteriophage

mu-1 insertions, 809 Recombination, site-specific

Excision of prophage X in cell-free system, 2188 Recommended Daily Allowance

Further comments on ascorbic acid requirement, 4151 Redshift



Reduction Radical mechanisms for 1,5-dihydroflavin reduction of carbonyl

compounds, 1763 Regulation

see also Autoregulation; Bioregulation; Control; Enzyme regulation; Feedback

Regulation, autogenous Autogenous regulation of inducible tryptophan synthase of Pseudomonas

putida, 1249 Regulation, cellular

Translocation of heart cAMP-dependent protein kinase, 1501 Regulation, genetic

see Gene regulation Renal clearance

Role of epithelial architecture and intracellular metabolism in proline uptake and transtubular reclamation in'PRO/Re mouse kidney, 1431

Renilla Chemical nature of bioluminescence systems in coelenterates, 1546 Renilla-type luciferin extracted from calcium-activated photoproteins

aequorin, mnemiopsin, and berovin, 2530 Reovirus

Genome-sized RNA from reovirus particles, 4317 5'-Terminal m7G(5')ppp(5')Grp in vivo: Identification in reovirus

genome RNA, 742



52 Subject Index

Replica printing Isolation of Escherichia coli mutants defective in enzymes of membrane

lipid synthesis, 2274 Replication

Bidirectional replication of plasmid R6K DNA in Escherichia coli: Correspondence between origin of replication and position of single-strand break in relaxed complex, 2905

T antigen binds to simian virus 40 DNA at the origin of replication, 1605 Replication-defective virus

RNA of replication-defective strains of'Rous sarcoma virus, 1569 Replication factor Y

Association of 4X174 DNA-dependent ATPase activity with Escherichia coli protein, replication factor Y, required for in vitro synthesis of kX174 DNA, 3342

Replication, viral Structure-function relationships and mode of replication of animal

rhabdoviruses, 933 Representation theory

Characters of holomorphic discrete series, 3275 Repression, transient

Adenosine 3':5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli, 2300

Repressor Autogenous regulation of inducible tryptophan synthase of Pseudomonas

putida, 1249 Initiation of in vitro mRNA synthesis from wild-type lac promoter, 4394 Mechanism of bacteriophage lambda induction: Acquisition of binding

sites for lambda repressor by host DNA, 1973 Proteolytic cleavage of bacteriophage lambda repressor in induction, 147 Repression and autogenous stimulation in vitro by bacteriophage lambda

repressor, 804 A Repressor turns off transcription of its own gene, 4785

Reproduction Inherited "neoplasm" in a fungus, 4626

Reproductive effort Natural selection and evolution of reproductive effort, 2227

Reptile Acetylcholine receptors at neuromuscular synapses: Phylogenetic

differences detected by snake a-neurotoxins, 3245 Amphisbaenian ear: Blanus cinereus and Diplometopon zarudnyi, 1487

Research A foundation for research (Symposium), 2843

Resistance, transepithelial Structure of tight junctions in epithelia with different permeability, 4487

Resistor-capacitor analogue Analogue solution for electrical capacity of membrane covered square

cylinders in square array at high concentration, 4936 Resonance Raman spectroscopy

see also Raman spectroscopy Raman resonance of electron donor/acceptor complexes, 4196 Resonance Raman effect in A-oxo-bis[iron(III)tetraphenylporphyrin],

4419 Respiration


Respiratory protein Kinetics of binding of carbon monoxide to Lumbricus erythrocruorin: A

possible model, 4313 Respiratory syncytial virus

Recovery of infectious proviral DNA from mammalian cells infected with respiratory syncytial virus, 3230

Restriction endonuclease see Endonuclease, restriction

Retina Light-stimulated phosphorylation of rhodopsin in retina: Protein kinase

specific for photobleached rhodopsin, 381 Purification and characterization of retina-specific cell-aggregating

factor, 916 Retinal, 9,13-dicis

Isorhodopsin: II. Artificial photosensitive pigment formed from 9,13-dicis retinal, 1538

Retinoblastoma Mutation and childhood cancer: Probabilistic model for incidence of

retinoblastoma, 5116 Reverse transcriptase

see Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid dependent

Reversion of transformed state Initiation and maintenance of cell transformation by simian virus 40: A

viral genetic property, 673 R factor

see Plasmid, R Rhabdovirus, animal

Structure-function relationships and mode of replication of animal rhabdoviruses, 933

Rhodopseudomonas spheroides Primary acceptor in bacterial photosynthesis: Obligatory role of


Rhodopsin Light-stimulated phosphorylation of rhodopsin in retina: Protein kinase

specific for photobleached rhodopsin, 381 Rho factor

Transcription termination factor rho activity is altered in Escherichia coli with suA gene mutations, 1725

Ribonuclease, guanylyl-specific Differential activity staining: Use in characterization of guanylyl-specific

ribonuclease in genus Ustilago, 4914


Ribonuclease H see Hybrid nuclease

Ribonuclease III Cleavage of adenovirus messenger RNA and of 28S and 18S ribosomal

RNA by RNase III, 3077 Ribonuclease 0

Sequential processing of precursor tRNA molecules in Escherichia coli, 3369

Ribonuclease P Sequential processing of precursor tRNA molecules in Escherichia coli,

3369 Three steps in conversion of large precursor RNA into serine and proline

transfer RNAs, 1491 Ribonuclease Q

Sequential processing of precursor tRNA molecules in Escherichia coli, 3369

Ribonuclease Tl Dynamics of protein matrix revealed by fluorescence quenching, 3290

Ribonucleic acid see also Polynucleotide

Ribonucleic acid chain breakage Effects of alkylation of phosphodiesters and of bases on infectivity and

stability of tobacco mosaic virus RNA, 2232 Ribonucleic acid chain synthesis

Estrogen affects gene expression in chick oviduct: Nuclear receptor levels and initiation of transcription, 4228

Ribonucleic acid, cytoplasmic RNAs of simian virus 40 in productively infected monkey cells: Kinetics

of formation and decay in enucleate cells, 2587 Ribonucleic acid-deoxyribonucleic acid linked molecule


Ribonucleic acid-dependent deoxyribonucleic acid nucleotidyltransferase Inhibition of oncornavirus functions by 2'-azido polynucleotides, 284

Ribonucleic acid dependent deoxyribonucleic acid polymerase see Deoxyribonucleic acid nucleotidyltransferase, ribonucleic acid

dependent Ribonucleic acid, double-stranded

Chemical nature of transfer factor (authors' statement), 409 Genome-sized RNA from reovirus particles, 4317 Inhibition of protein synthesis in rabbit reticulocyte lysates by


Structural features of double-stranded polyribonucleotides required for immunological specificity and interferon induction, 4564

Ribonucleic acid gene Use of gene 32 protein staining of single-strand polynucleotides for gene

mapping by electron microscopy: Application to k80d3ilvsu+7 system, 4506

Ribonucleic acid guanylyl transferase 5'-Terminus of mRNA modified by soluble guanylyl and methyl

transferases from vaccinia virus, 2525 Ribonucleic acid, heterogeneous nuclear


Inhibition of Balbiani ring RNA synthesis at initiation level, 947 Ribonucleoprotein particles containing heterogeneous nuclear RNA in

cellular slime mold Dictyostelium discoideum, 301 Ribonucleic acid, high-molecular-weight precursor

Adenovirus-2 mRNA is transcribed as part of high-molecular-weight precursor RNA, 4445

Ribonucleic acid ligase T4-induced RNA ligase joins single-stranded oligoribonucleotides, 122

Ribonucleic acid, messenger An intercistronic region and ribosome-binding site in bacterial messenger

RNA, 2399 How ribosomes select initiator regions in mRNA: Base pair formation


Induction by RNA of inositol independence in Neurospora crassa, 642 Non-specific stimulation of cell-free protein synthesis by a dialyzable

factor isolated from reticulocyte initiation factors ("iRNA"), 714 Synthesis of specific functional messenger RNA in vitro by

phage-SPOl-modified RNA polymerase of Bacillus subtilis, 4886 Translation in vitro of rat brain messenger RNA coding for tubulin and

actin, 701 Translation of hormone-induced messenger RNA in amphibian oocytes:


Translation of thyroglobulin 33S messenger RNA as means of determining thyroglobulin quaternary structure, 3839

Ribonucleic acid, messenger, adenovirus Adenovirus-2 mRNA is transcribed as part of high-molecular-weight

precursor RNA, 4445 Cleavage of adenovirus messenger RNA and of 28S and 18S ribosomal

RNA by RNase III, 3077 Ribonucleic acid, messenger, globin

Absence of polyadenylate segment in globin messenger RNA accelerates its degradation in Xenopus oocytes, 3065

Chemical and physical properties of fractionated chromatin, 3328 Demonstration of non-functional /3-globin mRNA in homozygous

/?-thalassemia, 5140 Differentiation in erythroleukemic cells and their somatic hybrids, 98 Electrophoretic patterns of deadenylylated chorion and globin mRNAs,

2959 Hemoglobin Cranston, unstable variant having elongated /3 chain due to

nonhomologous crossover between two normal /3 chain genes, 3609




Human globin gene expression and linkage in bone marrow and fetal liver, 258


Quantitative deficiency of chain-specific globin mRNA in thalassemia syndromes, 567

Relative numbers of human globin genes assayed with purified a and /3 * complementary human DNA, 1550 Rous sarcoma virus activates embryonic globin genes in chicken

fibroblasts, 4464 Strand-selective transcription of globin genes in rabbit erythroid cells

and chromatin, 4835 Synthesis of DNA complementary to separated human alpha and beta

globin messenger RNAs, 984 Testosterone stimulation of rapidly labeled, low-molecular-weight RNA

fraction in human hepatic erythroid cells in culture, 523 Ribonucleic acid, messenger, HeLa

Methylated, blocked 5' termini in HeLa cell mRNA, 1904 Short-lived messenger RNA in HeLa cells and its impact on kinetics of

accumulation of cytoplasmic polyadenylate, 389 Ribonucleic acid, messenger, human

Very short-lived and stable mRNAs from resting human lymphocytes, 3873

Ribonucleic acid, messenger, immunoglobulin Authors' statement on the isolation of mRNA coding for immunoglobulin

heavy chain (correction), 4679 Cell-free translation of immunoglobulin messenger RNA from


Region of immunoglobulin light-chain mRNA transcribed into complementary DNA by RNA-dependent DNA polymerase of avian myeloblastosis virus, 2511

Ribonucleic acid, messenger, insect chorion Electrophoretic patterns of deadenylylated chorion and globin mRNAs,

2959 Ribonucleic acid, messenger, insulin

Translation of messenger ribonucleic acid from isolated pancreatic islets and human insulinomas, 4777

Ribonucleic acid, messenger, interferon Biosynthesis of mouse interferon by translation of its messenger RNA in

a cell-free system, 3975 Interferon activity produced by translation of human interferon


Ribonucleic acid, messenger, metabolism see also Ribonucleic acid, messenger, stability; Ribonucleic acid,

messenger, turnover RNAs of simian virus 40 in productively infected monkey cells: Kinetics

of formation and decay in enucleate cells, 2587 Ribonucleic acid, messenger, methylation

see also Ribonucleic acid, methylated Methylated, blocked 5' termini in HeLa cell mRNA, 1904 Methylated nucleotides block 5'-terminus of vaccinia virus messenger

RNA, 318 Methylated nucleotides block 5'-terminus of vaccinia virus messenger

RNA (correction), 1645 Methylation-dependent translation of viral messenger RNAs in vitro,

1189 Methylation of messenger RNA of Newcastle disease virus in vitro by

virion-associated enzyme, 2611 Reovirus messenger RNA contains a methylated, blocked 5'-terminal

structure: m7G(5')ppp(5')GmpCp-, 362 Reovirus messenger RNA contains a methylated, blocked 5'-terminal

structure: m7G(5')ppp(5')GmpCp- (correction), 2468 5'-Terminus of mRNA modified by soluble guanylyl and methyl

transferases from vaccinia virus, 2525 Ribonucleic acid, messenger, pancreatic secretory proteins


Ribonucleic acid, messenger, polyadenylylated see also Polyadenylate; Ribonucleic acid, polyadenylylated Absence of polyadenylate segment in globin messenger RNA accelerates

its degradation in Xenopus oocytes, 3065 Cell-free synthesis of human interferon, 3898 Presence of polyriboadenylate sequences in pulse-labeled RNA of

Escherichia coli, 2910 Ribonucleic acid, messenger, prokaryotic

Very stable prokaryotic messenger RNA in chromosomeless Escherichia coli minicells, 2900

Ribonucleic acid, messenger, reovirus Reovirus messenger RNA contains a methylated, blocked 5'-terminal

structure: m7G(5')ppp(5')GmpCp-, 362 Reovirus messenger RNA contains a methylated, blocked 5'-terminal

structure: m7G(5')ppp(5')GmpCp- (correction), 2468 5'-Terminal m7G(5')ppp(5')Gmp in vivo: Identification in reovirus

genome RNA, 742 Ribonucleic acid, messenger, stability

see also Ribonucleic acid, messenger, metabolism; Ribonucleic acid, messenger, turnover

Absence of polyadenylate segment in globin messenger RNA accelerates its degradation in Xenopus oocytes, 3065

Ribonucleic acid, messenger, synthesis Functional level of rat liver tryptophan 2,3-dioxygenase messenger RNA

during superinduction of enzyme with actinomycin D, 4285 Initiation of in vitro mRNA synthesis from wild-type lac promoter, 4394 RNA from heat-induced polysomes at puff sites in Drosophila

melanogaster, 1117

Subject Index 53

Ribonucleic acid, messenger, turnover see also Ribonucleic acid, messenger, metabolism; Ribonucleic acid,

messenger, stability Absence of polyadenylate segment in globin messenger RNA accelerates

its degradation in Xenopus oocytes, 3065 Kinetics of steroid induction and deinduction of tyrosine

aminotransferase synthesis in cultured hepatoma cells, 2007 Poly(A) shortening and mRNA turnover. 1077 RNAs of simian virus 40 in productively infected monkey cells: Kinetics

of formation and decay in enucleate cells, 2587 Ribonucleic acid, messenger, vaccinia virus

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA, 318

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA (correction), 1645

Ribonucleic acid, messenger, vesicular stomatitis virus Coupled in vitro transcription and translation of vesicular stomatitis

virus messenger RNA, 2545 Ribonucleic acid, messenger, viral

Methylation-dependent translation of viral messenger RNAs in vitro, 1189

Translation and identification of mRNA species synthesized in vitro by virion-associated RNA polymerase of vesicular stomatitis virus, 274

Ribonucleic acid, messenger, vitellogenin Effect of estrogen on gene expression: Purification of vitellogenin

messenger RNA, 3364 Ribonucleic acid metabolism

Nuclear and cytoplasmic poly(adenylic acid), 3580 RNAs of simian virus 40 in productively infected monkey cells: Kinetics

of formation and decay in enucleate cells, 2587 Ribonucleic acid, methylated

see also Ribonucleic acid, messenger, methylation Methylated simian virus 40-specific RNA from nuclei and cytoplasm of

infected BSC-1 cells, 2012 Ribonucleic acid methyl transferase

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA, 318

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA (correction), 1645

5'-Terminus of mRNA modified by soluble guanylyl and methyl transferases from vaccinia virus, 2525

Ribonucleic acid, microvariant Nucleotide sequence of microvariant RNA: Another small replicating

molecule, 4252 Ribonucleic acid nucleotide sequence

Nucleotide sequence of microvariant RNA: Another small replicating molecule, 4252

Nucleotide sequence of RNA polymerase binding site at early T7 promoter, 784

Sequence of 71 nucleotides at 3'-end of tobacco mosaic virus RNA, 864 3'-Terminal nucleotide sequence (n = 361) of bacteriophage MS2 RNA,

2559 Ribonucleic acid nucleotidyltransferase

Enhancement of soybean RNA polymerase I by auxin, 69 Enhancement of soybean RNA polymerase I by auxin (correction), 2468 Hamster a-amanitine-resistant RNA polymerase II able to transcribe

polyoma virus genome in somatic cell hybrids, 753 Increased frequency of initiation of RNA synthesis due to a protein

factor from chicken myeloblastosis nuclei, 2935 Methylation of messenger RNA of Newcastle disease virus in vitro by

virion-associated enzyme, 2611 Strand-selective transcription of globin genes in rabbit erythroid cells

and chromatin, 4835 3'-Terminal nucleotide sequence (n = 361) of bacteriophage MS2 RNA,

2559 Translation and identification of mRNA species synthesized in vitro by

virion-associated RNA polymerase of vesicular stomatitis virus, 274 Ribonucleic acid nucleotidyltransferase, deoxyribonucleic acid dependent

Distinct molecular structures of nuclear class I, II, and III deoxyribonucleic acid-dependent ribonucleic acid polymerases, 348


Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6) Conversion of Bacillus subtilis RNA polymerase activity in vitro by a

protein induced by phage SPOI, 2366 Dissociation of two polypeptide chains from yeast RNA polymerase A,

3034 Effects of bacteriophage T4-induced modification of Escherichia coli

RNA polymerase on gene expression in vitro, 4928 Estrogen affects gene expression in chick oviduct: Nuclear receptor levels

and initiation of transcription, 4228 Highly asymmetric transcription by RNA polymerase containing

phage-SPOl-induced polypeptides and a new host protein, 1589 Identification of gene for the a-subunit of RNA polymerase at the

str-spc region of Escherichia coli chromosome, 5036 Link between streptomycin and rifampicin mutation, 2084 Separation of lymphocyte chromatin into template-active fractions with


Sigma cycle during in vitro transcription: Demonstration by nanosecond fluorescence depolarization spectroscopy, 3019

Synthesis of specific functional messenger RNA in vitro by phage-SPOl-modified RNA polymerase of Bacillus subtilis, 4886

Temperature-sensitive RNA polymerase mutants with altered subunit synthesis and degradation, 2375

Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6) binding site Nucleotide sequence of RNA polymerase binding site at early T7

promoter, 784



54 Subject Index


Nucleotide sequence of RNA polymerase binding site from DNA of bacteriophage fd (correction), 2468

Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6), phosphorylation In vivo and in vitro phosphorylation of DNA-dependent RNA


Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6) subunit Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal

RNA, and RNA polymerase subunits, 2743 Identification of gene for the a-subunit of RNA polymerase at the

str-spc region of Escherichia coli chromosome, 5036 Temperature-sensitive RNA polymerase mutants with altered subunit

synthesis and degradation, 2375 Ribonucleic acid nucleotidyltransferase (EC 2.7.7.6), synthesis

Regulation of RNA polymerase synthesis in Escherichia coli: Mutant unable to synthesize enzyme at 43?, 911

Ribonucleic acid, polyadenylylated see also Polyadenylate; Ribonucleic acid, messenger, polyadenylylated Electrophoretic patterns of deadenylylated chorion and globin mRNAs,

2959 In vitro addition of polyadenylate sequence to 3' end of phage Q/ RNA

and biological activity of product, 428 Poly(adenylic acid) sequences in the RNA of Caulobacter crescentus,

2343 Search for nucleic acid sequences complementary to a murine

oncornaviral genome in poly(A)-rich RNA of human leukemic cells, 4900


Very short-lived and stable mRNAs from resting human lymphocytes, 3873

Ribonucleic acid polymerase see Ribonucleic acid nucleotidyltransferase

Ribonucleic acid primer for deoxyribonucleic acid synthesis R-factor replication in presence of chloramphenicol, 654 RNA-primed DNA synthesis: Specific catalysis by HeLa cell DNA

polymerase a, 503 Ribonucleic acid, production

De novo production of self-replicating and environmentally adapted RNA structures by bacteriophage Q/ replicase, 162

Ribonucleic acid, pulse-labeled Presence of polyriboadenylate sequences in pulse-labeled RNA of

'Escherichia coli, 2910 Ribonucleic acid, reovirus


Ribonucleic acid replication Intermediates in biosynthesis of double-stranded ribonucleic acids of

bacteriophage 06, 849 Site-directed mutagenesis: Extracistronic mutation affecting in vitro

propagation of bacteriophage Q/ RNA, 367 Ribonucleic acid, ribosomal

Binding of ribosomal protein S1 of Escherichia coli to the 3' end of 16S rRNA, 2940

Changes in ribosomal RNA processing paths in resting and phytohemagglutinin-stimulated guinea pig lymphocytes, 3315

Cleavage of adenovirus messenger RNA and of 28S and 18S ribosomal RNA by RNase III, 3077

Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal RNA, and RNA polymerase subunits, 2743

Effects of guanosine tetraphosphate on cell-free synthesis of Escherichia coli ribosomal RNA and other gene products, 2881

How ribosomes select initiator regions in mRNA: Base pair formation between 3' terminus of 16S rRNA and mRNA during initiation of protein synthesis in Escherichia coli, 4734

Identification of a region in 23S rRNA located at peptidyl transferase center, 4332


Prokaryotic nature of red algal chloroplasts, 2310 Ribonucleic acid, Rous sarcoma virus

In vitro synthesis of full-length DNA transcripts of Rous sarcoma virus RNA by viral DNA polymerase, 4895


Ribonucleic acid, 70S Viral-related information in oncornavirus-like particles isolated from


Ribonucleic acid secondary structure Method for predicting RNA secondary structure, 2017

Ribonucleic acid sequence see Ribonucleic acid nucleotide sequence

Ribonucleic acid, simian-virus-40-specific Methylated simian virus 40-specific RNA from nuclei and cytoplasm of

infected BSC-1 cells, 2012 Ribonucleic acid synthesis


Chromatin as template for RNA synthesis in vitro, 194 Chromatin directed transcription of 5S and tRNA genes, 1082 Increased frequency of initiation of RNA synthesis due to a protein

factor from chicken myeloblastosis nuclei, 2935 Inhibition of Balbiani ring RNA synthesis at initiation level, 947


Intermediates in biosynthesis of double-stranded ribonucleic acids of bacteriophage 46, 849

Minimal requirements for template recognition by bacteriophage Q,B replicase: General RNA-dependent RNA synthesis, 2640

Parallel changes in puffing activity and patterns of protein synthesis in salivary glands of Drosophila, 3604

RNA synthesis in isolated brain nuclei after administration of d-lysergic acid diethylamide (LSD) in vivo, 837

Synthesis of RNA containing a methylated blocked 5' terminus by HeLa nuclear homogenates, 2930

T4-induced RNA ligase joins single-stranded oligoribonucleotides, 122 Ribonucleic acid, 5'-terminus

32P-labeling of ribonucleic acids at 5'-ends after isolation, 314 5'-Terminal m7G(5')ppp(5')Gmp in vivo: Identification in reovirus

genome RNA, 742 5'-iTerminus of mRNA modified by soluble guanylyl and methyl

transferases from vaccinia virus, 2525 Ribonucleic acid, transfer


Interaction of elongation factor Tu with 2'(3')-O-aminoacyloligonucleotides derived from the 3' terminus of aminoacyl-tRNA, 2950

Ribonucleic acid, transfer, aminoacylation Amino acids are not all initially attached to the same position on

transfer RNA molecules, 3044 Interaction of elongation factor Tu with

2'(3')-O-aminoacyloligonucleotides derived from the 3' terminus of aminoacyl-tRNA, 2950

Metabolites influence control of lysine transfer ribonucleic acid synthetase formation in Escherichia coli K-12, 1364

Site of aminoacylation of tRNAs from Escherichia coli with respect to 2'- or 3'-hydroxyl group of terminal adenosine, 3049

Ribonucleic acid, transfer, -C-C-A end Site of aminoacylation of tRNAs from Escherichia coli with respect to

2'- or 3'-hydroxyl group of terminal adenosine, 3049 Ribonucleic acid, transfer, conformation

see also Ribonucleic acid, transfer, structure Allosteric mechanism for codon-dependent tRNA selection on ribosomes,

4248 Ribonucleic acid, transfer, N-formylmethionine


Ribonucleic acid, transfer, isoaccepting Separation of transfer ribonucleic acid by Sepharose chromatography

using reverse salt gradients, 1068 Ribonucleic acid, transfer, methionine

Interaction of poly(A) and mRNA with eukaryotic initiator Met-tRNAf binding factor: Activity on reticulocyte ribonucleic acid protein particles, 1021


Ribonucleic acid, transfer, nucleotidyltransferase (EC 2.7.7.25) Three steps in conversion of large precursor RNA into serine and proline

transfer RNAs, 1491 Ribonucleic acid, transfer, oligopeptidyl

(Oligo)peptidyl-tRNA released from ribosomes by erythromycin A, 2649 Ribonucleic acid, transfer, phenylalanine

Hydrogen bonding in yeast phenylalanine transfer RNA, 4866 Phenylalanyl-tRNA synthetase from baker's yeast: Role of 3'-terminal

adenosine of tRNAPhe in enzyme-substrate interaction studied with 3'-modified tRNAPhe species, 1378

Structure of yeast phenylalanine transfer RNA at 2.5 A resolution, 4414 Ribonucleic acid, transfer, 31P magnetic resonance

31p magnetic resonance of tRNA, 3482 Ribonucleic acid, transfer, precursor

Method for the isolation of specific tRNA precursors, 4790 Sequential processing of precursor tRNA molecules in Escherichia coli,

3369 Three steps in conversion of large precursor RNA into serine and proline

transfer RNAs, 1491 Ribonucleic acid, transfer, primer


Ribonucleic acid, transfer, proline Three steps in conversion of large precursor RNA into serine and proline

transfer RNAs, 1491 Ribonucleic acid, transfer, separation


Ribonucleic acid, transfer, serine Three steps in conversion of large precursor RNA into serine and proline

transfer RNAs, 1491 Ribonucleic acid, transfer, spin-labeled

Proton nuclear magnetic resonance of spin-labeled Escherichia coli tRNAflMet, 2582

Ribonucleic acid, transfer, structure Allosteric mechanism for codon-dependent tRNA selection on ribosomes,

4248 Method for predicting RNA secondary structure, 2017 Proton nuclear magnetic resonance of spin-labeled Escherichia coli

tRNAflMet, 2582 Tertiary hydrogen bonds in solution structure of transfer RNA, 2049

Ribonucleic acid, transfer, tryptophan Ability of tryptophan tRNA to hybridize with 35S RNA of avian




myeloblastosis virus and to prime reverse transcription in vitro, 2155 Specific binding of tryptophan transfer RNA to avian myeloblastosis

virus RNA-dependent DNA polymerase (reverse transcriptase), 2535 Ribonucleic acid, transfer, tyrosine

Promoter-dependent transcription of tRNAiTYr genes using DNA fragments produced by restriction enzymes, 4754

Ribonucleic acid, translational control Two classes of translational control RNA: Their role in the regulation of

protein synthesis, 1523 Ribonucleic acid tumor virus

see Tumor virus, ribonucleic acid Ribonucleic acid, viral

Analysis of oncornavirus RNA subunits by electron microscopy, 3716 Effects of alkylation of phosphodiesters and of bases on infectivity and

stability of tobacco mosaic virus RNA, 2232 Host induced alteration of avian sarcoma virus B-77 genome, 1031 Identification of 5' end of Rous sarcoma virus RNA, 3347 Quasi-elastic behavior of solutions of viral capsid and RNA at very low

shearing stresses, 3501 RNA of replication-defective strains of Rous sarcoma virus, 1569 Sequence of 71 nucleotides at 3'-end of tobacco mosaic virus RNA, 864 Site-directed mutagenesis: Extracistronic mutation affecting in vitro

propagation of bacteriophage Q/ RNA, 367 Viral RNA of murine leukemia virus after infection, 343

Ribonucleic acid virus Oncornavirus-like particles in human skin cancers, 3697 Recovery of infectious proviral DNA from mammalian cells infected with

respiratory syncytial virus, 3230 Selective blockage of initiation of host protein synthesis in

RNA-virus-infected cells, 1258 Spontaneous and induced mutagenesis in western equine

encephalomyelitis virus in chick embryo cells with different repair activity, 386

Ribonucleoprotein Interaction of poly(A) and mRNA with eukaryotic initiator Met-tRNAf




Ribonucleotide reduction NADPH-thioredoxin reductase system identified in Euglena gracilis,

4233 Ribophosphotriester


Ribosomal decoding site Affinity labeling of the ribosomal decoding site with an AUG-substrate

analog, 1505 Ribosomal protein

see Protein, ribosomal Ribosomal protein gene

Identification of gene for the a-subunit of RNA polymerase at the str-spc region of Escherichia coli chromosome, 5036


Specialized transducing phages for ribosomal protein genes of Escherichia coli, 6

Ribosomal ribonucleic acid see Ribonucleic acid, ribosomal

Ribosome Allosteric mechanism for codon-dependent tRNA selection on ribosomes,

4248 Architecture of Escherichia coli ribosome as determined by immune

electron microscopy, 4820 How ribosomes select initiator regions in mRNA: Base pair formation


Photoincorporation of puromycin and N-(ethyl-2-diazomalonyl)puromycin into Escherichia coli ribosomes, 2974

Soluble protein identified that stimulates peptide bond synthesis, 4257 Ribosome-binding site

An intercistronic region and ribosome-binding site in bacterial messenger RNA, 2399

Ribosome dissociation Dissociation of ribosomes of Escherichia coli by initiation factor IF-3,

4238 Ribosome, donor site

(Oligo)peptidyl-tRNA released from ribosomes by erythromycin A, 2649 Ribosome, eukaryotic


Ribosome, peptidyl transferase center Identification of a region in 23S rRNA located at peptidyl transferase

center, 4332 Ribosome subunit

Dissociation of ribosomes of Escherichia coli by initiation factor IF-3, 4238

Neutron scattering measurements of separation and shape of proteins in 30S ribosomal subunit of Escherichia coli: S2-S5, S5-S8, S3-S7, 3888



Ribosyl-trans-zeatin Cell-division factors from Vinca rosea L. crown gall tumor tissue, 1883

Subject Index 55

Cell-division factors from Vinca rosea L. crown gall tumor tissue (correction), 3260

Ribovirus Recovery of infectious proviral DNA from mammalian cells infected with

respiratory syncytial virus, 3230 Rice

see Oryza sativa Riemann Hypothesis

Almost all roots of ~(s)' a are arbitrarily close to a = 1/2, 1322 Riemannian manifold

Connectivities Ri of Frechet spaces in variational topology, 2069 Riemann's zeta-function

Almost all roots of ~(s) = a are arbitrarily close to a = 1/2, 1322 Deduction of semi-optimal mollifier for obtaining lower bound for No(T)

for Riemann's zeta-function, 294 Rifampicin

Link between streptomycin and rifampicin mutation, 2084 R-factor replication in presence of chloramphenicol, 654

RNA see Ribonucleic acid

Robertson Memorial Lecture Progress and prospects in high energy astrophysics, 4685

Rodent see also Guinea pig; Hamster; Mouse; Mus; Rat; Spalax South American mammal zoogeography: Convergent evolution in desert

rodents, 1702 Rolling circle replication

Reconstruction of bacteriophage T4 DNA replication apparatus from purified components: Rolling circle replication following de novo chain initiation on single-stranded circular DNA template, 4800

Root exudation General model for osmotic and pressure-induced flow in plant roots,

3114 Roots of ?(s)-'a

Almost all roots of c(s) = a are arbitrarily close to a = 1/2, 1322 Rotation, molecular



Rous sarcoma virus see also Avian sarcoma virus; Sarcoma virus A-type and C-type particles in cells infected by Rous sarcoma virus, 3706 Decrease in membrane-associated actin of fibroblasts after

transformation of Rous sarcoma virus, 746 Effect of oncogenic virus on muscle differentiation, 4051 Identification of 5' end of Rous sarcoma virus RNA, 3347 In vitro synthesis of full-length DNA transcripts of Rous sarcoma virus

RNA by viral DNA polymerase, 4895 Plasminogen-independent fibrinolysis by proteases produced.by

transformed chick embryo fibroblasts, 1132 Protein kinase and its regulatory effect on reverse transcriptase activity

of Rous sarcoma virus, 2945 RNA-directed DNA synthesis by DNA polymerase of Rous sarcoma

virus: Structural and functional identification of 4S primer RNA in uninfected cells, 859

RNA of replication-defective strains of Rous sarcoma virus, 1569 Rous sarcoma virus activates embryonic globin genes in chicken

fibroblasts, 4464 Structural change of plasma membrane induced by oncogenic viruses:

Quantitative studies with freeze-fracture technique, 1695 Surface ruffles as markers for studies of cell transformation by Rous

sarcoma virus, 3144 Translation of Rous sarcoma virus RNA in cell-free system from ascites

Krebs II cells, 614 Rubidium



Rubredoxin Determination of iron-sulfur distances in rubredoxin by x-ray absorption

spectroscopy, 4003 NH...S Hydrogen bonds in Peptococcus aerogenes ferredoxin,

Clostridium pasteurianum rubredoxin, and Chromatium high potential iron protein, 4854

Synthetic analogs of active sites of iron-sulfur proteins: Bis(o-xylyldithiolato)ferrate(III) monoanion, a structurally unconstrained model for rubredoxin Fe-S4 unit, 2868

Ruffle, cell surface Surface ruffles as markers for studies of cell transformation by Rous

sarcoma virus, 3144 Runge pairs


Ruthenium(III), tris(bipyridine)- Reaction of tris(bipyridine)ruthenium(III) with hydroxide and its

application in a solar energy storage system, 2858

Saccharomyces cerevisiae Cell cycle-dependent induction of mutations along yeast chromosome,

1179 Complementation in cytoplasmic petite mutants of yeast to form

respiratory competent cells, 372 Cytoplasmic mutants of Saccharomyces cerevisiae with specific lesions

in cytochrome oxidase, 2054



56 Subject Index

Electron microscopic observations on meiotic karyotype of diploid and tetraploid'Saccharomyces cerevisiae, 5056

Enzyme activity, cell geometry, and fitness in Saccharomyces cerevisiae, 794

Restriction endonuclease analysis of mitochondrial DNA from grande and genetically characterized cytoplasmic petite clones of Saccharomyces cerevisiae, 3868

Single-strand scissions of chromosomal DNA during commitment to recombination at meiosis, 1887

Saliva, human parotid Zinc protein isolated from human parotid saliva, 488

Salivary gland of Drosophila Parallel changes in puffing activity and patterns of protein synthesis in

salivary glands of Drosophila, 3604 Salmonella/microsome test


Salmonella typhimurium Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): Positive effector for

histidine operon transcription and general signal for amino-acid deficiency, 4389


Quantitation of sensory response in bacterial chemotaxis, 710 Salmonella mutants associated with germfree rats: Site specific model to

detect carcinogens as mutagens, 4607 Sandhoffs disease


Sarcoma virus see also Avian sarcoma.virus; Rous sarcoma virus Cellular protein synthesis required in reversal of


Host induced alteration of avian sarcoma virus B-77 genome, 1031 p60 Polypeptide in feline leukemia virus pseudotype of Moloney sarcoma

virus with murine leukemia virus p30 antigenic determinants, 2380 Search for nucleic acid sequences complementary to a murine

oncornaviral genome in poly(A)-rich RNA of human leukemic cells, 4900

Separation of sarcoma virus-specific and leukemia virus-specific genetic sequences of Moloney sarcoma virus, 4650


Scattering, deep inelastic Source theory discussion of deep inelastic scattering with polarized

particles, 1559 Schizophrenia


Dopamine receptor binding in corpus striatum of mammalian brain, 4655 Phenothiazine drugs: Structure-activity relationships explained by

conformation that mimics dopamine, 1899 Schwartz space

Theorem on the Schwartz space of a reductive Lie group, 4718 Science education

NSF and science education-Who, why, and how did it work out (Symposium), 2848

Screening of chemicals Detection of carcinogens as mutagens in Salmonella/microsome test:

Assay of 300 chemicals, 5135 Scurvy

Further comments on ascorbic acid requirement, 4151 Sea urchin

see Strongylocentrotus purpuratus Sea urchin egg



Secretory granule Cytochemical study of secretory process in transplantable insulinoma of

Syrian golden hamster, 4501 Sediment, pre-Phanerozoic


Seed Breaking of seed dormancy by catalase inhibition, 306

Selection see also Methodology (genetics and selection); Natural selection

Selection, interpopulation Evolution of social behavior through interpopulation selection, 1199

Semigroups of operators Infinitesimal generators and quasi-units in potential theory, 2498

Sendai virus Restoration of ultraviolet-induced unscheduled DNA synthesis of


Sensing device Bacteriophage T4 whiskers: Rudimentary environment-sensing device,

3701 Sensory deprivation


Sequential estimation Sequential estimation of p with squared relative error loss, 191

Serine protease see also Protease




Serotonin Brain tryptophan hydroxylase: Purification of, production of antibodies

to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain, 3575

Synthesis and biological properties of 9,11-azo-prostanoid: Highly active biochemical mimic of prostaglandin endoperoxides, 3355

Serotonin:acetyl coenzyme A N-acetyltransferase (EC 2.3.1.5) Ontogenesis of biological clock for serotonin:acetyl coenzyme A

N-acetyltransferase in pineal gland of rat, 2814 Serotype, altered

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype, 1427

Serre conjecture Exhaustion functions and Stein neighborhoods for smooth pseudoconvex

domains, 3279 Serum

see also Plasma Folate binding factor in normal umbilical cord serum purified, 4261 Induction of growth in resting fibroblastic cell cultures by Ca++, 1584 Virus-specific neutralization by soluble non-immunoglobulin factor

found naturally in normal mouse sera, 5071 Serum factor


Sexuality Sexuality in cellular slime mold Dictyostelium giganteum, 970

Shimura curve Some fundamental groups in arithmetic of algebraic curves over finite

fields, 3281 Sialidase

Interaction of cholera toxin and membrane GM, ganglioside of small intestine, 2520

Sialoglycoprotein Amino-acid sequence and oligosaccharide attachment sites of human

erythrocyte glycophorin, 2964 Sickle cell disease

Bis(N-maleimidomethyl) ether: Antisickling reagent, 4153 Dimethyl adipimidate: New antisickling agent, 43 Isolation of antibodies specific to sickle hemoglobin by affinity

chromatography using a synthetic peptide, 4759 Quantitative deficiency of chain-specific globin mRNA in thalassemia

syndromes, 567 Sickle cell fiber

Hemoglobin interaction in sickle cell fibers: Theoretical approaches to molecular contacts, 1330

Sidechain torsional potential Sidechain torsional potentials and motion of amino acids in proteins:

Bovine pancreatic trypsin inhibitor, 2002 Sigma = 1/2

Almost all roots of '(s) = a are arbitrarily close to a = 1/2, 1322 Sigma cycle

Sigma cycle during in vitro transcription: Demonstration by nanosecond fluorescence depolarization spectroscopy, 3019

Significant structure theory Significant structure theory applied to mesophase system, 78

Simian virus 40 Appearance of smaller mannosyl-glycopeptides on surface of a human

cell transformed by simian virus 40, 2687 Determination of number of superhelical turns in simian virus 40 DNA

by gel electrophoresis, 4876 Failure of human cells transformed by simian virus 40 to form tumors in

athymic nude mice, 4971 Folding of DNA double helix in chromatin-like structures from simian

virus 40, 1843 Homology and relationship between genomes of papovaviruses, BK virus

and simian virus 40, 2563 Initiation and maintenance of cell transformation by simian virus 40: A

viral genetic property, 673 Mapping mutational alterations in DNA with S1 nuclease: Location of

deletions and temperature-sensitive mutations in simian virus 40, 989 Methylated simian virus 40-specific RNA from nuclei and cytoplasm of

infected BSC-1 cells, 2012 Partially purified simian virus 40 T antigen interacts with circular viral

DNA molecules, 1960 RNAs of simian virus 40 in productively infected monkey cells: Kinetics

of formation and decay in enucleate cells, 2587 Simian virus 40 DNA directs synthesis of authentic viral polypeptides in

linked transcription-translation cell-free system, 1922 Simian virus 40-related antigens in three human meningiomas with

defined chromosome loss, 609 Specificity of substrate recognition by EcoRI restriction endonuclease,

3310 T antigen binds to simian virus 40 DNA at the origin of replication, 1605 Thermolabile T (tumor) antigen from cells transformed by

temperature-sensitive mutant of simian virus 40, 4351 Simian virus 40 genome



Singular integral Singular integrals and the principal series, IV, 2459

Sipunculan worm Tertiary structure of myohemerythrin at low resolution, 2160




Slide, nickel-plated Daily periodicity in the activity of a slide used to perform immunologic

reactions at a liquid-solid interface, 2462 Slime mold

see Dictyostelium; Polysphondylium Smooth pseudoconvex domain


Smut see Ustilago

Snake see Squamata

Social structuring Social structuring of mammalian populations and rate of chromosomal

evolution, 5061 Sodium


Components of 02-uptake by excised frog nerve dependent upon externally supplied sodium ions, 3988



Kinetics of opiate receptor inactivation by sulfhydryl reagents: Evidence for conformational change in presence of sodium ions, 2404

Spike-forming model of neural membrane, 3468 Titration of sodium channels in canine gastric mucosa, 3731

Solar system Condensation time of solar nebula from extinct 129I in primitive

meteorites, 268 Solubilization of antigen-antibody aggregate

New complement function: Solubilization of antigen-antibody aggregates, 418

Solvent exchange Neutron scattering study of human serum low density lipoprotein, 2270

Somatic cell genetics see Genetics, somatic cell

Somatic cell hybrid see Hybrid cell

Somatomedin Enhancement of somatomedin titers of normal and hypopituitary sera by

addition of L-triiodothyronine in vitro at physiological concentrations, 604

Isolation of cationic polypeptide from human serum that stimulates proliferation of 3T3 cells, 2635

Somatostatin Immunoreacti~e somatostatin is present in discrete cells of endocrine


pancreas (correction), 2833 Somatotropin

Human pituitary growth hormone: Biologically active hendekakaihekaton peptide fragment corresponding to amino-acid residues 15-125 in the hormone molecule, 3878

Pituitary growth hormones: Evolutionary conservatism based on immunochemical studies, 4322

Plasmin digests of S-carbamidomethylated human growth hormone, 1684 Sound speed

Motion of a slightly compressible fluid, 539 Source theory


Source theory discussion of deep inelastic scattering with polarized particles, 1559

Soybean see Glycine max

Spalax ehrenbergi Aggression patterns and speciation, 3250

Speciation Aggression patterns and speciation, 3250 Social structuring of mammalian populations and rate of chromosomal

evolution, 5061 Theory of evolution above the species level, 646

Species interaction Allelopathy and spatial competition among coral reef invertebrates, 5160

Species richness Species richness of parasitic fungi of British trees, 2116

Species selection Theory of evolution above the species level, 646

Spectator-ion effect Spectator-ion effect on passage of ions through membranes, 683

Spectral probe Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase

A: Monitor of catalytic events, 3930 Spectral problem

Well-posed inverse spectral problems, 2496 Spectrin

Detection and ultrastructural localization of human smooth muscle myosin-like molecules in human non-muscle cells by specific antibodies, 1359

Spectroscopy see also Electron paramagnetic resonance; Fluorescence; Methodology

(spectroscopy); Nuclear magnetic resonance; X-ray absorption spectroscopy

Spectroscopy, picosecond Picosecond detection of intermediate in photochemical reaction of

bacterial photosynthesis, 2251

Subject Index 57

Sperm Chemical induction of sperm abnormalities in mice, 4425 Mn2+-Sensitive, "soluble" adenylate cyclase in rat testis, 1097 Ribonuclease-sensitive DNA-synthesizing complex in human sperm

heads and seminal fluid, 3295 Spermatogenesis


New histones found in mature mammalian testes, 2714 Spermidine


Spermine Biosynthesis of mouse interferon by translation of its messenger RNA in

a cell-free system, 3975 Increased cellular levels of spermidine or spermine are required for


Sphere, liquid, rotating Theory of homogeneous dynamos in a rotating liquid sphere, 1496

Spherical model, modified On some modified spherical models, 4723

Spike-forming model Spike-forming model of neural membrane: Computer simulation of some

perfused axon experiments, 4859 Spinal cord, frog

Presynaptic action of barbiturates in frog spinal cord, 1460 Spindle fiber

Presence of actin during chromosomal movement, 2451 Spin label

see also Electron paramagnetic resonance Antigen mobility in membranes and complement-mediated immune

attack, 2483 Conformational change and cooperativity in actin filaments free of

tropomyosin, 3412 Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by

concanavalin A, 4409 Motion of subfragment-1 in myosin and its supramolecular complexes:

Saturation transfer electron paramagnetic resonance, 1729 Proton nuclear magnetic resonance of spin-labeled Escherichia coli

tRNAfMet, 2582 Spin-labeled long chain acylcholine interacts with cholinergic acceptor

protein in membrane environment, 1087 Stabilization of electron spin resonance probes for photosynthesis

studies, 3107 Spin-lattice relaxation




Spirillum lipoferum Potential for nitrogen fixation in maize genotypes in Brazil, 2389

Spleen focus-forming virus Induction of endogenous and of spleen focus-forming viruses during

dimethylsulfoxide-induced differentiation of mouse erythroleukemia celts transformed by spleen focus-forming virus, 1863

Spleen, leukemic, human Purification of RNA-instructed DNA polymerase from human leukemic

spleens, 4133 Sporulation



Spreading technique Protein-free spreading of double- and single-stranded nucleic acid

molecules, 83 "Spshing noise"

"Spshing noise": Biological significance of its attraction and nonattraction by birds, 1411

SQ-20881 (nonapeptide) Mechanism and modification of bradykinin-induced coronary

vasodilation, 2060 Squalene

Cholesterol synthesis in man measured by isotope kinetics of squalene, 4612

Squamata Acetylcholine receptors at neuromuscular synapses: Phylogenetic

differences detected by snake a-neurotoxins, 3245 Squared relative error loss

Sequential estimation of p with squared relative error loss, 191 Staining, differential activity

Differential activity staining: Use in characterization of guanylyl-specific ribonuclease in genus Ustilago, 4914

Staphylococcus aureus Plasmid interactions in Staphylococcus aureus: Nonadditivity of

compatible plasmid DNA pools, 5031 Star, neutron

Progress and prospects in high energy astrophysics, 4685 Statistics

Distributions associated with Bose-Einstein statistics, 1654 Life games and statistical models, 956 Nonidentifiability aspect of problem of competing risks, 20 Partial knowledge, entropy, and estimation, 3819 Power of optimal asymptotic tests of composite statistical hypotheses, 577



58 Subject Index

Sequential estimation of p with squared relative error loss, 191 Stochastic models for Earth's relief, shape and fractal dimension of

coastlines, and number-area rule for islands, 3825 Steady state

Turning wheel: Study in steady states, 3983 Steinberg module

Homology of congruence subgroups and K3(Z), 651 Stein rieighborhood


Stereochemical correspondence Algebraic description of stereochemical correspondence, 2385

Stereoselection Enzymes as reagents in peptide synthesis: Enzymatic removal of amine

protecting groups, 2193 Steroid

see also specific steroids; Hormone, mammalian Androgen- and estrogen-binding macromolecules in developing mouse

brain: Biochemical and genetic evidence, 4303 ATP binding to progesterone receptor, 901 Control of mRNA for hepatic tryptophan oxygenase during hormonal

and substrate induction, 1017 Estrogen affects gene expression in chick oviduct: Nuclear receptor levels

and initiation of transcription, 4228 Influence of novel hypophyseal factor on steroid metabolism in cultured

hepatoma cells, 4986 Kinetics of steroid induction and deinduction of tyrosine

aminotransferase synthesis in cultured hepatoma cells, 2007 Partial purification of glucocorticoid receptor, 3849 Separation of "estrogen-induced" protein from phosphoprotein

phosphatase activity of immature rat uterus, 2631 Synthesis of vitellogenin in cultures of male and female frog liver

regulated by estradiol treatment in vitro, 3172 Steroidogenesis

Steroidogenesis in rabbit preimplantation embryos, 298 Sterol

Cholesterol synthesis in man measured by isotope kinetics of squalene, 4612


Stimulus-response relationship Quantitation of sensory response in bacterial chemotaxis, 710

Stimulus-secretion coupling Bioregulation of lysosomal enzyme secretion from human neutrophils:


Stochastic model Stochastic models for Earth's relief, shape and fractal dimension of

coastlines, and number-area rule for islands, 3825 Stochastic process

Moments for sum of an arbitrary function of gene frequency along a stochastic path of gene frequency change, 1602

Stochastics Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams,

1291 Stopped flow

see Kinetics Storage diseases


Streptococcus faecalis Biosynthesis of ribosylthymine in the transfer RNA of Streptococcus


Plasmid-determined tetracycline resistance in Streptococcus faecalis: Gene amplification during growth with tetracycline, 1720

Streptomycin mutation Link between streptomycin and rifampicin mutation, 2084

Strongylocentrotus purpuratus Histone gene arrangement in sea urchin Strongylocentrotus purpuratus,

4815 Structure-activity relationship


Structure, beta Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution:

Chain tracing and metal ligands, 1349 Structure determination

see Methodology (structure determination) Structure-function

Third component of complement (C3): Structural properties in relation to functions, 1989

Structure, quaternary Translation of thyroglobulin 33S messenger RNA as means of

determining thyroglobulin quaternary structure, 3839 Stuart factor

see Factor X Sturm-Liouville problem

Well-posed inverse spectral problems, 2496 Suberimidate, dimethyl

Octamer of histones in chromatin and free in solution, 2626 Substrate

Binding protein-independent substrate translocation by methylgalactoside transport system of Escherichia coli K12, 423


Control of oscillating glycolysis of yeast by stochastic, periodic, and steady source of substrate: Model and experimental study, 3829


Specificity of substrate recognition by EcoRI restriction endonuclease, 3310

Subtractive algorithm Analysis of subtractive algorithm for greatest common divisors, 4720

Subunit inequivalence Magnitude of subunit inequivalence for oxygen release from hemoglobin:

Reinvestigation of oxygen-pulse experiment, 3998 Sugar

see specific sugars; Carbohydrate Sulfation of mucopolysaccharide


Sulfhydryl see also Disulfide; Thiol Effect of chemical inactivating agents on glucocorticoid receptor proteins

in mouse and hamster cells, 3060 Kinetics of opiate receptor inactivation by sulfhydryl reagents: Evidence

for conformational change in presence of sodium ions, 2404 Sulfhydryl dependence in primary explant hematopoietic cells:

Inhibition of growth in vitro with vitamin B12 compounds, 73 Sulfonamide resistance

Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases, 2621

Sulfur metabolism Control of the synthesis of a single enzyme by multiple regulatory

circuits in Neurospora crassa, 1240 Superconductivity

Insertion compounds of 2H-TaS2-NH3, 464 Superoxide dismutase, Cu,Zn

Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: Chain tracing and metal ligands, 1349

Supersonic transport Estimates of stratospheric pollution by analytic model, 4711

Survival Control of ovarian cell growth in culture by serum and pituitary factors,

483 Nonidentifiability aspect of problem of competing risks, 20

SV40 see Simian virus 40

Sweet protein Crystallization and crystal data of monellin, 398

Symbiosis see also Endosymbiosis

Symbiosis, bacterium-protozoon Heme biosynthesis in bacterium-protozoon symbioses: Enzymic defects


Symmetry rule Concerning Jahn-Teller effects, 2104

Sympathetic ganglion, chemically axotomized Nerve growth factor induces volume increase and enhances tyrosine



Sympathetic role in hypertension Changes in cyclic nucleotide metabolism in aorta and heart of


Symposium A foundation for research (Symposium), 2843 Description of molecular structure (Symposium), 763 National Science Foundation: Origins, hopes, and aspirations

(Symposium), 2839 NSF and science education-Who, why, and how did it work out

(Symposium), 2848 Whither NSF?-The higher derivatives (Symposium), 2853

Synapse Calcium role in depolarization-secretion coupling: Aequorin study in

squid giant synapse, 187 Cholinergic synapses formed between dissociated sympathetic neurons

and skeletal myotubes of rat in cell culture, 1955 1-Pyrene-butyrylcholine: A fluorescent probe for the cholinergic system,

3097 Receptor synapses without synaptic ribbons in cat cochlea, 3599

Synapsis Mechanism to activate branch migration between homologous DNA

molecules in genetic recombination, 279 Synaptic ribbon

Receptor synapses without synaptic ribbons in cat cochlea, 3599 Synaptonemal complex

Electron microscopic observations on meiotic karyotype of diploid and tetraploid Saccharomyces-cerevisiae, 5056

Synaptosome Differential sub-cellular compartmentalization of thyrotropin releasing


Synchrotron radiation X-ray absorption spectroscopy using synchrotron radiation for structural

investigation of organometallic molecules of biological interest, 2340 Synoviocyte

Human synoviocytes: Activation and desensitization by prostaglandins and l-epinephrine, 3124

Synthesis see specific classes of compounds; Methodology (synthesis)




Tantalum disulfide-ammonia Insertion compounds of 2H-TaS2-NH3, 464

T antigen see Antigen, tumor; Antigen, viral

Taste bud Zinc protein isolated from human parotid saliva, 488

Tau factor Inhibition of tubulin assembly by RNA and other polyanions: Evidence

for required protein, 3570 Protein factor essential for microtubule assembly, 1858

Tay-Sach's disease Tay-Sachs' and Sandhoffs diseases: Assignment of genes for

hexosaminidase A and B to individual human chromosomes, 263 T-cell

see Cell, thymus-derived; Lymphocyte, thymus-derived Template-primer

Ability of tryptophan tRNA to hybridize with 35S RNA of avian myeloblastosis virus and to prime reverse transcription in vitro, 2155


Template recognition Minimal requirements for template recognition by bacteriophage Q,B

replicase: General RNA-dependent RNA synthesis, 2640 Template requirement

Dissociation of two polypeptide chains from yeast RNA polymerase A, 3034

Teratogen Chemical induction of sperm abnormalities in mice, 4425

Teratoma cell, murine Absence of H-2 antigens capable of reacting with cytotoxic T cells on

teratoma line expressing T/t locus antigen, 3661 Terminal deoxynucleotidyl transferase (EC 2.7.7.31)

Antibody to terminal deoxynucleotidyl transferase, 4119 Terminal riboadenylate transferase

In vitro addition of polyadenylate sequence to 3' end of phage Q/ RNA and biological activity of product, 428

Termination of protein synthesis see Polypeptide chain termination and initiation; Protein synthesis

5' Terminus of ribonucleic acid, methylated blocked Synthesis of RNA containing a methylated blocked 5' terminus by HeLa

nuclear homogenates, 2930 Testicular feminization



Testis, rat Mn2+-Sensitive, "soluble" adenylate cyclase in rat testis, 1.097

Testosterone Effect of castration and testosterone replacement on circadian

pacemaker in mice (Mus musculus), 3744 Follicle-stimulating hormone stimulates estradiol-17/ synthesis in

cultured Sertoli cells, 2677 Testosterone stimulation of rapidly labeled, low-molecular-weight RNA

fraction in human hepatic erythroid cells in culture, 523 Testosterone, dihydro-



Tetraalkylammonium salt Effects of tetraalkylammonium salts on Brdicka and presodium currents

of bovine-serum albumin, 2863 Tetracycline

Plasmid-determined tetracycline resistance in Streptococcus faecalis: Gene amplification during growth with tetracycline, 1720

Tetrad analysis Genetic analysis in dinoflagellate Crypthecodinium (Gyrodinium)

cohnii: Unusual meiosis, 4546 Tetrahydrofolate dehydrogenase (EC 1.5.1.3)

Competitive protein binding assay for methotrexate, 3683 Tetrahymena pyriformis

Absence of histone Fl in mitotically dividing, genetically inactive nucleus, 2672

Subunit structure of naturally occurring chromatin lacking histones Fl and F3, 3536

Tetrodotoxin Components of 02-uptake by excised frog nerve dependent upon

externally supplied sodium ions, 3988 Thalassemia

Demonstration of non-functional /-globin mRNA in homozygous /?-thalassemia, 5140

Expression of /-thalassemia gene in first trimester fetus, 3633 Human globin gene analysis for patient with 00?//0-thalassemia, 2294 Imbalanced globin chain synthesis in heterozygous /-thalassemic bone

marrow, 3853 Quantitative deficiency of chain-specific globin mRNA in thalassemia

syndromes, 567 Relative numbers of human globin genes assayed with purified a and 3

complementary human DNA, 1550 Synthesis of DNA complementary to separated human alpha and beta

globin messenger RNAs, 984 Themiste (syn. Dendrostomum) pyroides

Tertiary structure of myohemerythrin at low resolution, 2160 Thermal motion

Phase problem in crystallography, 1699 Thermochemotherapy

Thermochemotherapy: Synergism between hyperthermia (42-43?) and

Subject Index 59

adriamycin (or bleomycin) in mammalian cell inactivation, 937 Thermodynamic potential

Group of thermodynamic potentials applicable to ligand binding by a polyfunctional macromolecule, 1464

Thermodynamics Gross thermodynamics of heat engines in deep interior Earth, 1555

Thermolysin Energy transfer between terbium(III) and cobalt(II) in thermolysin: New

class of metal-metal distance probes, 4764 Thermolysin (EC 3.4.24.4)

Homologous relationship between thermolysin and neutral protease A of Bacillus subtilis, 4341

Thermotaxis Normal and mutant thermotaxis in nematode Caenorhabditis elegans,

4061 Theta-function

Intertwining operators and automorphic forms for the metaplectic group, 1406

Thiol see also Sulfhydryl

Thiol-containing peptides Rapid and specific method for isolation of thiol-containing peptides from

large proteins by thiol-disulfide exchange on solid support, 3029 Thioredoxin reductase (NADPH) (EC 1.6.4.5)

NADPH-thioredoxin reductase system identified in Euglena gracilis, 4233

Thioredoxin-S2 Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A

resolution, 2305 Thrombin


Thrombin (EC 3.4.21.5) Mitogenic activity of blood components: I. Thrombin and prothrombin,

131 Thromboxane

Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides, 2994

Thymidine kinase (EC 2.7.1.75) Possible peptide chain termination mutants in thymidine kinase gene of

herpes simplex virus, 4081 Thymidine nucleotide pool

Model for compartmentation of de novo and salvage thymidine nucleotide pools in mammalian cells, 3333

Thymine Biosynthesis of ribosylthymine in the transfer RNA of Streptococcus


Thymoma Trisomy of chromosome 15 in spontaneous leukemia of AKR mice, 1515

Thymus Differentiation of peripheral blood lymphocytes into cells bearing sheep

erythrocyte receptors in vitro by human thymic extract, 1175 Immunological relationship between acetylcholine receptor and thymus:

A possible significance in myasthenia gravis, 1456 Thyroglobulin


Thyroid hormone Nuclear receptors for thyroid hormone: Nonrandom distribution within

chromatin, 1787 Thyroliberin


Differential sub-cellular compartmentalization of thyrotropin releasing hormone (TRH) and gonadotropin releasing hormone (LRH) in hypothalamic tissue, 3153

Effect of hypothalamic deafferentation on thyrotropin-releasing hormone levels in rat brain, 4177

Thyrotropin releasing hormone see Thyroliberin

Thyroxin Specific endocrine and hormonal receptor changes associated with liver

regeneration in adult rats, 4033 Tight junction

Establishment of tight junctions between epithelial cells, 2711 Structure of tight junctions in epithelia with different permeability, 4487

Tindaria callistiformis Slow growth rate of deep-sea clam determined by 228Ra chronology, 2829

Tissue culture Differentiation of clonal lines of teratocarcinoma cells: Formation of

embryoid bodies in vitro, 1441 Tissue water


Myelin structure transformed by dimethylsulfoxide, 3513 Titanium dioxide electrode

Photoassisted electrolysis of water by irradiation of a titanium dioxide electrode, 1518

Tits building Homology of congruence subgroups and K3(Z), 651

Toad see Bufo; Xenopus

Tobacco culture Anticytokinin activity of substituted pyrrolo[2,3-d]pyrimidines, 3508

Tobacco mosaic virus Effects of alkylation of phosphodiesters and of bases on infectivity and



60 Subject Index

stability of tobacco mosaic virus RNA, 2232 -Sequence of 71 nucleotides at 3'-end of tobacco mosaic virus RNA, 864

Toda lattice On some periodic Toda lattices, 1627

Tokamak Adiabatic evolution of plasma equilibrium, 3789

Tooth enamel Aspartic acid racemization in tooth enamel from living humans, 2891

Topology, variational Connectivities Ri of Frechet spaces in variational topology, 2069

Torpedo marmorata Regulation of binding properties of nicotinic receptor protein by


L-1-Tosylamido-2-phenylethyl chloromethyl ketone Selective effects of inhibitors of protein synthesis on metabolism of

nuclear and cytoplasmic proteins: Coordinate synthesis of nonhistone chromosomal proteins, 4450

Toxin see also Bactrachotoxin; Cytotoxin; Endotoxin; Lymphotoxin;

Neurotoxin; Tetrodotoxin Toxin, cholera

Activation of adenylate cyclase by cholera toxin, 3438 Cholera toxin activation of adenylate cyclase in cancer cell membrane

fragments, 2572 Interaction of cholera toxin and membrane GM1 ganglioside of small

intestine, 2520 Mechanism of action of cholera toxin and mobile receptor theory of

hormone receptor-adenylate cyclase interactions, 33 Nicotinamide adenine dinucleotide in action of cholera toxin in vitro,

2064 Stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol:

Effect of cholera toxin, 3561 Toxin, diphtheria

Genetic analysis of cell surface: Association of human chromosome 5 with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids, 2237

On alleged high sensitivity of mouse Ehrlich-Lettre ascites tumor cells to diphtheria toxin, 3149

Toxin, Pseudomnonas aeruginosa NAD-dependent inhibition of protein synthesis by Pseudomonas

aeruginosa toxin, 2284 Toxin, scorpion

Cooperative activation of action potential Na+ ionophore by neurotoxins, 1782


Transcriptiori see also specific genes and proteins

Transcriptional control Conversion of Bacillus subtilis RNA polymerase activity in vitro by a

protein induced by phage SPOl, 2366 In vivo and in vitro phosphorylation of DNA-dependent RNA


Transcription of deoxyribonucleic acid Chemical and physical properties of fractionated chromatin, 3328 Chromatin directed transcription of 5S and tRNA genes, 1082 Dissociation of two polypeptide chains from yeast RNA polymerase A,

3034 Estrogen affects gene expression in chick oviduct: Nuclear receptor levels

and initiation of transcription, 4228 Highly asymmetric transcription by RNA polymerase containing

phage-SPOl-induced polypeptides and a new host protein, 1589 In vitro synthesis of full-length DNA transcripts of Rous sarcoma virus

RNA by viral DNA polymerase, 4895 Promoter-dependent transcription of tRNAiTYr genes using DNA

fragments produced by restriction enzymes, 4754 A Repressor turns off transcription of its own gene, 4785 Sigma cycle during in vitro transcription: Demonstration by nanosecond

fluorescence depolarization spectroscopy, 3019 Strand-selective transcription of globin genes in rabbit erythroid cells

and chromatin, 4835 Transcription termination and late control in phage lambda, 3300

Transcription, reverse Ability of tryptophan tRNA to hybridize with 35S RNA of avian

myeloblastosis virus and to prime reverse transcription in vitro, 2155 Ribonuclease-sensitive DNA-synthesizing complex in human sperm

heads and seminal fluid, 3295 Transduction, specialized

Acquisition of determinant for chloramphenicol resistance by coliphage lambda, 5041

Transfection Infectious viral DNA of murine leukemia virus, 4910 Recovery of infectious proviral DNA from mammalian cells infected with

respiratory syncytial virus, 3230 Transfer factor

Chemical nature of transfer factor (authors' statement), 409 Guinea pig transfer factor-like activity detected in vitro, 4573 Transfer factor: Subcellular component that transmits information for

specific immune responses (authors' statement), 409 Transfer ribonucleic acid

see Ribonucleic acid, transfer Transformation, fibroblast

Formation of bone marrow in fibroblast-transformation ossicles, 2212 Transformation of animal cells by chemicals




Transformation of animal cells by virus Appearance of smaller mannosyl-glycopeptides on surface of a human

cell transformed by simian virus 40, 2687 Cellular protein synthesis required in reversal of



Decrease in membrane-associated actin of fibroblasts after transformation of Rous sarcoma virus, 746



Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice, 4971



Initiation and maintenance of cell transformation by simian virus 40: A viral genetic property, 673

Mapping of biological functions on RNA of avian tumor viruses: Location of regions required for transformation and determination of host range, 4772

Organization of actin and myosin in normal and transformed cultured cells, 994

Plasminogen-independent fibrinolysis by proteases produced by transformed chick embryo fibroblasts, 1132


Separation of sarcoma virus-specific and leukemia virus-specific genetic sequences of Moloney sarcoma virus, 4650


Surface ruffles as markers for studies of cell transformation by Rous sarcoma virus, 3144

Thermolabile T (tumor) antigen from cells transformed by temperature-sensitive mutant of simian virus 40, 4351


Transformation of lymphoid cells in vitro by Abelson murine leukemia virus, 1932

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro, 4435


Transformation of bacteria by deoxyribonucleic acid Competent Bacillus subtilis cultures synthesize denatured DNA binding

activity, 323 Electrophoretic separation of Bacillus subtilis genes, 2207 Transformation of Pseudomonas putida and Escherichia coli with

plasmid-linked drug-resistance factor DNA, 3647 Transformation of mold cells

Induction by RNA of inositol independence in Neurospora crassa, 642 Transformation of plant cells

Integration of exogenous bacterial DNA into plant DNA, 2748 Transformed animal cell

see also cell entries Transformed animal cell (chemical)

Differences in membrane fluidity and structure in contact-inhibited and transformed cells (correction), 1217


Transformed animal cell (virus) Differences in membrane fluidity and structure in contact-inhibited and

transformed cells (correction), 1217 Plasma membrane alteration associated with malignant transformation

in culture, 3594 Selective killing of transformed baby hamster kidney (BHK) cells, 4994 Tumorigenicity of virus-transformed cells in nude mice is correlated

specifically with anchorage independent growth in vitro, 4435 Transglutaminase

Crosslinking and labeling of membrane proteins by transglutaminase-catalyzed reactions, 2568

Transition dipole coupling Transition dipole coupling in Amide I modes of /3 polypeptides, 4933

Transition metal Maximum-valence radii of transition metals, 3799 Valence-bond theory of compounds of transition metals, 4200

Translational control Functional level of rat liver tryptophan 2,3-dioxygenase messenger RNA

during superinduction of enzyme with actinomycin D, 4285 Inhibition of protein synthesis in rabbit reticulocyte lysates by


Permeability lesions in male Escherichia coli infected with bacteriophage T7, 2222


Translation of genetic information see also Protein synthesis




Allosteric mechanism for codon-dependent tRNA selection on ribosomes, 4248

Association of cyclic AMP-dependent protein kinase with purified translational inhibitor isolated from hemin-deficient rabbit reticulocyte lysates, 4849

Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system, 3975

Demonstration of non-functional f/-globin mRNA in homozygous /?-thalassemia, 5140




Translation in vitro of rat brain messenger RNA coding for tubulin and actin, 701

Translation of hormone-induced messenger RNA in amphibian oocytes: Induction by estrogen of messenger RNA encoded for vitellogenic protein in liver of male African clawed toad (Xenopus laevis), 3934




Translocation, genetic see also Chromosome translocation Site-specific recA-independent recombination between bacterial



Transphosphorylation Central role for magnesium in coordinate control of metabolism and

growth in animal cells, 3551 Transplantation, heterotopic


Transport see also specific compounds; Electron transport; Protein, binding Active transport of calcium in inverted vesicles of Escherichia coli

(correction), 2833 Binding protein-independent substrate translocation by

methylgalactoside transport system of Escherichia coli K12, 423 Cycle of deprotonation and reprotonation energizing amino-acid

transport? 23 Diabetes mellitus: Changes in transport properties of isolated intestinal

microvillous membranes, 2027 Identification of aldosterone-induced proteins in toad's urinary bladder,

4056 Mitochondrial carnitine acylcarnitine translocase system, 883 Nonsaturable, homogeneous transport system in Bacillus subtilis:

Genetic, kinetic, and affinity labeling studies, 814 Paired moving charge model of energy coupling: III. Intrinsic ionophores

in energy coupling systems, 896 Reversible effects of chaotropic agents on proton permeability of

Escherichia coli membrane vesicles, 3387 Role of epithelial architecture and intracellular metabolism in proline

uptake and transtubular reclamation in PRO/Re mouse kidney, 1431 Role of leucyl-tRNA synthetase in regulation of branched-chain

amino-acid transport, 3921 Serum rapidly stimulates ouabain-sensitive 86Rb+ influx in quiescent

3T3 cells, 4492 Significance of retention of ligand by protein, 2120 Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams,

1291 Structure of tight junctions in epithelia with different permeability, 4487 Ubiquinone-mediated coupling of NADH dehydrogenase to active

transport in membrane vesicles from Escherichia coli, 3970 Utilization of L-cystine by y-glutamyl transpeptidase--y-glutamyl

cyclotransferase pathway, 1985 X and Y operators for general linear transport processes, 1210

Tree, British Species richness of parasitic fungi of British trees, 2116

Triamcinolone Hormonal effects on structure and catalytic properties of fructose

1,6-bisphosphatase, 2969 Triiodothyronine



Thyroid hormone binding by component of mitochondrial membrane, 3225

Triplet states of molecules Absence of interference in photoexcitation of triplets, 4203

Trisomy Gene dosage: Assignment of erythrocyte acid phosphatase locus to

chromosome 2, 4526 Trisomy of chromosome 15 in spontaneous leukemia of AKR mice, 1515

Triticum aestivum Genetic control of endosperm amylase activity and gibberellic acid

responses in standard-height and short-statured wheats, 892 Triton X-100

In vitro synthesis of full-length DNA transcripts of Rous sarcoma virus RNA by viral DNA polymerase, 4895

Subject Index 61

Separation of 1-acylglycerolphosphate acyltransferase and 1-acylglycerolphosphorylcholine acyltransferase of rat liver microsomes, 600

Trophic radiation Trophic radiation through polymorphism in cichlid fishes, 4669

Tropomyosin Intramolecular crosslinking of tropomyosin via disulfide bond formation:

Evidence for chain register, 3377 Major nonhistone proteins of rat liver chromatin: Preliminary

identification of myosin, actin, tubulin, and tropomyosin, 3902 Troponin

Amino-acid sequence of parvalBumin from rabbit skeletal muscle, 1309 Trypsin

Enzymes as reagents in peptide synthesis: Enzymatic removal of amine protecting groups, 2193

Resonance Raman spectroscopic studies of interactions between trypsin and competitive inhibitor, 4223

Trypsin (EC 3.4.21.4) Molecular orbital studies of enzyme activity: Charge relay system and

tetrahedral intermediate in acylation of serine proteinases, 2606 Trypsin-Giemsa banding

Trisomy of chromosome 15 in spontaneous leukemia of AKR mice, 1515 Trypsin inhibitor, bovine pancreatic

Sidechain torsional potentials and motion of amino acids in proteins: Bovine pancreatic trypsin inhibitor, 2002

Tryptophan see also Operon, tryptophan Antigen-induced conformational changes in antibodies and their Fab

fragments studied by circular polarization of fluorescence, 2775 Dynamic and static quenching of 1,N6-ethenoadenine fluorescence in

nicotinamide 1,N-ethenoadenine dinucleotide and in 1,N6-etheno-9-[3-(indol-3-yl)propyl]adenine, 3966

Tryptophan 2,3-dioxygenase (EC 1.13.11.11) Control of mRNA for hepatic tryptophan oxygenase during hormonal

and substrate induction, 1017 Functional level of rat liver tryptophan 2,3-dioxygenase messenger RNA

during superinduction of enzyme with actinomycin D, 4285 Tryptophan hydroxylase

see Tryptophan 5-monooxygenase (EC 1.14.16.4) Tryptophan 5-monooxygenase (EC 1.14.16.4)


Tryptophan synthase (EC 4.2.1.20) Autogenous regulation of inducible tryptophan synthase of Pseudomonas

putida, 1249 Tubulin

Antibody against tubulin: Specific visualization of cytoplasmic microtubules in tissue culture cells, 459

Assembly of chick brain tubulin onto flagellar microtubules from Chlamydomonas and sea urchin sperm, 1122

Assembly of microtubules onto kinetochores of isolated mitotic chromosomes of HeLa cells, 4023


Cytoplasmic microtubules in normal and transformed cells in culture: Analysis by tubulin antibody immunofluorescence, 4981

Inhibition of tubulin assembly by RNA and other polyanions: Evidence for required protein, 3570


Protein factor essential for microtubule assembly, 1858 Translation in vitro of rat brain messenger RNA coding for tubulin and

actin, 701 Visualization of actin fibers associated with cell membrane in amoebae of

Dictyostelium discoideum, 1758 Tumbling


Tumor see also Cancer Failure of human cells transformed by simian virus 40 to form tumors in

athymic nude mice, 4971 New cell surface antigens in rat defined by tumors of the nervous

system, 1296 Solid tumor models for assessment of different treatment modalities:


Tumor growth Solid tumor models for assessment of different treatment modalities:


Tumorigenicity see also Oncogenesis Correlated suppression by 5-bromodeoxyuridine of tumorigenicity and

plasminogen activator in mouse melanoma cells, 47 Failure of human cells transformed by simian virus 40 to form tumors in

athymic nude mice, 4971 Tumorigenicity of virus-transformed cells in nude mice is correlated

specifically with anchorage independent growth in vitro, 4435 Tumor immunology

see also Antigen, tumor; Immune surveillance Comparison between macrophage activation and enhancement of

nonspecific resistance to tumors by mycobacterial immunoadjuvants, 4105

Different responses of lymphoid cells from tumor-bearing as compared to tumor-immunized mice when sensitized to tumor specific antigens in vitro, 5086



62 Subject Index


Tumor-associated determinant(s) of carcinoembryonic antigen, 1528 Tumor inhibition

Tumor-inhibiting properties of the neutral P-O-ethyl ester of adenosine 3':5'-morxophosphate in correlation With its crystal and molecular structure, 1335

Tumor necrosis Endotoxin-induced serum factor that causes necrosis of tumors, 3666

Tumor regression Tumor regression at untreated site during immunotherapy of identical

distant tumor, 3680 Tumor virus

see also specific viruses Inhibition of oncornavirus functions by 2'-azido polynucleotides, 284 Relationship in nucleic acid sequences between mouse mammary tumor

virus variants, 4635 Transformation of cultured human embryonic fibroblasts by


Tumor virus, ribonucleic acid Ability of tryptophan tRNA to hybridize with 35S RNA of avian

myeloblastosis virus and to prime reverse transcription in vitro, 2155 Growth and differentiation in culture of leukemic leukocytes from


Relationship in nucleic acid sequences between mouse mammary tumor virus variants, 4635




Tunicate see Ascidia

Type C virus see C-type virus

Tyrosinase see Monophenol monooxygenase (EC 1.14.18.1)

Tyrosine aminotransferase (EC 2.6.1.5) Kinetics of steroid induction and deinduction of tyrosine

aminotransferase synthesis in cultured hepatoma cells, 2007 Tyrosine hydroxylase

see Tyrosine 3-monooxygenase (EC 1.14.16.2) Tyrosine 3-monooxygenase


Tyrosine 3-monooxygenase (EC 1.14.16.2) ATP, cyclic AMP, and magnesium increase affinity of rat striatal

tyrosine hydroxylase for its cofactor, 2955 Circadian rhythm of tyrosine hydroxylase induction by short-term cold



Nerve growth factor induces volume increase and enhances tyrosine hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats, 595


Neuronal properties of hybrid neuroblastoma X sympathetic ganglion cells, 4923



Tyrosine peptide homology Tyrosine peptide homologies in the HLA antigen system, 5081

Ubiquinone Primary acceptor in bacterial photosynthesis: Obligatory role of



Ubisemiquinone Interaction of ubisemiquinone with a paramagnetic component in heart

tissue, 2886 Ultraviolet irradiation

Inducible error-prone repair in Escherichia coli, 2753 Repair of ultraviolet irradiation damage to cytoplasmic component

required for neural induction in amphibian egg, 1235 Restoration of ultraviolet-induced unscheduled DNA synthesis of






Umbilical cord serum, human Folate binding factor in normal umbilical cord serum purified, 4261

Uptake see specific compounds; Protein, binding; Transport

Uracil, propylthio- Experimental alcohol-induced hepatic necrosis: Suppression by

propylthiouracil, 1137 Urea


Uridine-diphosphate-N-acetylglucosamine-glycoprotein N-acetylglucosaminyltransferase (EC 2.4.1.51)

Chinese hamster ovary cells selected for resistance to cytotoxicity of phytohemagglutinin are deficient in a UDP-N- acetylglucosamine-glycoprotein N-acetylglucosaminyltransferase activity, 3323

Uridine-diphosphate-glucose 4-epimerase (EC 5.1.3.2) Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes

in culture, 5026 Uridylyl removing enzyme


Uro-isocoproporphyria Porphyria variegata and porphyria cutanea tarda in siblings: Chemical

and genetic aspects, 5126 Urokinase (EC 3.4.99.26)

Amino-acid sequence of activation cleavage site in plasminogen: Homology with "pro" part of prothrombin, 2577

Uroporphyrinogen I synthase (EC 4.3.1.8) Heme biosynthesis in bacterium-protozoon symbioses: Enzymic defects


Ustilago Differential activity staining: Use in characterization of guanylyl-specific

ribonuclease in genus Ustilago, 4914 Uterus

Estrogen-directed synthesis of specific prostaglandins in uterus, 1420

Vaccinia virus Methylated nucleotides block 5'-terminus of vaccinia virus messenger

RNA, 318 Methylated nucleotides block 5'-terminus of vaccinia virus messenger

RNA (correction), 1645 5'-Terminus of mRNA modified by soluble guanylyl and methyl

transferases from vaccinia virus, 2525 Vacuole, secretion

Translocation of 5'-nucleotidase across hepatic membranes in vivo, 4013 Valence bond

Valence-bond theory of compounds of transition metals, 4200 Valine metabolism

[13C]Valine metabolism in methylmalonicacidemia using nuclear magnetic resonance: Propionate as obligate intermediate, 3692

Vanadium chromogen Nuclear magnetic resonance spectrum of living tunicate blood cells and

structure of native vanadium chromogen, 2217 Variance, phenotypic

Genetic determinant of phenotypic variance of molecular weight of low density lipoprotein, 2347

Variational formula Variational formula for principal eigenvalue for operators with maximum

principle, 780 Vascular permeability, cerebral


Vector lattice Infinitesimal generators and quasi-units in potential theory, 2498

Veratridine Cooperative activation of action potential Na+ ionophore by neurotoxins,


(correction), 3260 Vertical transmission


Vesicle Alamethicin-mediated fusion of lecithin vesicles, 2170

Vesicular stomatitis virus Coupled in vitro transcription and translation of vesicular stomatitis

virus messenger RNA, 2545 Interferon action: II. Membrane-bound alkaline ribonuclease activity in

chick embryo cells manifesting interferon-mediated interference, 182 New Jersey serotype of vesicular stomatitis virus and its defective

particles, 1202 Translation and identification of mRNA species synthesized in vitro by

virion-associated RNA polymerase of vesicular stomatitis virus, 274 Vibrational spectra

Transition dipole coupling in Amide I modes of 3 polypeptides, 4933 Vinyl chloride


Virus see also specific viruses; Bacteriophage; Ribonucleic acid virus

Virus, endogenous Induction of endogenous murine C-type virus in spleen cell cultures

treated with mitogens and 5-bromo-2'-deoxyuridine, 535




Virus-induced suppression Selective blockage of initiation of host protein synthesis in

RNA-virus-infected cells, 1258 Virus induction

Mechanism of bacteriophage lambda induction: Acquisition of binding sites for lambda repressor by host DNA, 1973

Virus infection, trans-species Isolation from Asian mouse Mus caroli of endogenous type C virus

related to infectious primate type C viruses, 2315 Virus latency

Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells, 1477

Virus-specific neutralization Virus-specific neutralization by soluble non-immunoglobulin factor

found naturally in normal mouse sera, 5071 Viscosity


Kinetic theory of viscosity of compressed fluids, 1970 Quasi-elastic behavior of solutions of viral capsid and RNA at very low

shearing stresses, 3501 Visual system


Vitamin A see Retinal

Vitamin B-6 see Pyridoxal phosphate

Vitamin B-12 see Cobalamin

Vitamin C see Ascorbic acid

Vitamin D Cytoplasmic and nuclear binding components for

la,25-dihydroxyvitamin D3 in chick parathyroid glands, 4871 Group-specific component (Gc) proteins bind vitamin D and

25-hydroxyvitamin D, 2076 Rapid action of pure crystalline la-hydroxy vitamin D3 and

la,25-dihydroxy vitamin D3 on intestinal calcium uptake, 229 Vitamin K

Direct identification of the calcium-binding amino acid -y-carboxyglutamate in mineralized tissue, 3925

Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X, 1281

Vitellogenic protein Translation of hormone-induced messenger RNA in amphibian oocytes:


Vitellogenin Effect of estrogen on gene expression: Purification of vitellogenin

messenger RNA, 3364 Synthesis of vitellogenin in cultures of male and female frog liver

regulated by estradiol treatment in vitro, 3172 Voltage dependence

Voltage-dependence of drug-induced conductance in frog neuromuscular junction, 2140

von Willebrand factor Antibody nature of circulating inhibitor of plasma von Willebrand factor,

4167 Factor-VIII-related antigen: Multiple molecular forms in human plasma,

5121

Water mold see Blastocladiella; Coelomomyces

Water-protein interaction Activation volumes in enzymic catalysis: Their sources and modification

by low-molecular-weight solutes, 3014 Protein-water interaction studied by solvent 'H, 2H, and 170 magnetic

relaxation, 2667 Western equine encephalomyelitis virus

Spontaneous and induced mutagenesis in western equine encephalomyelitis virus in chick embryo cells with different repair activity, 386

Wheat see Triticum aestivum

Wheel, turning Turning wheel: Study in steady states, 3983

"Whiskers," bacteriophage T4 Bacteriophage T4 whiskers: Rudimentary environment-sensing device,

3701 Wiener-Pitt phenomenon

Spectra of convolution operators on Lp spaces, 3285

Subject Index 63

Wood decay Preparation and microbial decomposition of synthetic ['4C]lignins, 2515

Worm see Lumbricus; Themiste

Xenon isotopes Condensation time of solar nebula from extinct 129I in primitive

meteorites, 268 Xenopus laevis


Interferon activity produced by translation of human interferon messenger RNA in cell-free ribosomal systems and in Xenopus oocytes, 4881

Synthesis of vitellogenin in cultures of male and female frog liver regulated by estradiol treatment in vitro, 3'172

Translation of hormone-induced messenger RNA in amphibian oocytes: Induction by estrogen of messenger RNA encoded for vitellogenic protein in liver of male African clawed toad (Xenopus laevis), 3934

Xenotropic property Novel murine oncornavirus with dual eco- and xenotropic properties,

5150 Xeroderma pigmentosum

Genetic heterogeneity in xeroderma pigmentosum: Complementation groups and their relationship to DNA repair rates, 59





X-irradiation see also Radiation, ionizing Endonucleolytic incision of x-irradiated deoxyribonucleic acid by

extracts of Escherichia coli, 1997 Protection of lethally irradiated mice with allogeneic fetal liver cells:

Influence of irradiation dose on immunologic reconstitution, 4100 X-ray absorption spectroscopy

Determination of iron-sulfur distances in rubredoxin by x-ray absorption spectroscopy, 4003

X-ray absorption spectroscopy using synchrotron radiation for structural investigation of organometallic molecules of biological interest, 2340

X-ray diffraction Crystal structure of human erythrocyte carbonic anhydrase B:

Three-dimensional structure at nominal 2.2-A resolution, 51 Nerve growth factor crystallized from mouse submaxillary glands, 777 Structure of yeast phenylalanine transfer RNA at 2.5 A resolution, 4414 X-ray diffraction studies of human erythrocyte membrane structure, 531

Yeast see also Saccharomyces cerevisiae High resolution 31P nuclear magnetic resonance studies of intact yeast

cells, 4966 Reversible, coenzyme-A-mediated inactivation of biosynthetic

condensing enzymes in yeast: Regulatory mechanism, 1802 Yeast septum

Chitin synthetase zymogen is attached to yeast plasma membrane, 3952

Zea mays Potential for nitrogen fixation in maize genotypes in Brazil, 2389

Zeta-function Almost all roots of c(s) = a are arbitrarily close to a =1/2, 1322 Deduction of semi-optimal mollifier for obtaining lower bound for No(T)

for Riemann's zeta-function, 294 Zoogeography, South American mammal


Zymogen Activation of bovine factor X (Stuart factor): Conversion of factor Xaa to

factor Xai,, 3359 Amino-acid sequence of activation cleavage site in plasminogen:

Homology with "pro" part of prothrombin, 2577 Dissociation of bovine 6S procarboxypeptidase A by reversible


' Zymogram techniques Antigenic and enzymatic architecture of Micrococcus lysodeikticus

membranes established by crossed immunoelectrophoresis, 3711



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