AbortusChromosomal Abnormalities

Denny Suwanto

Chromosome Abnormalities

• Numerical– Euploid---multiple of haploid number (N)– Aneuploid---trisomy or monosomy

• Structural

Milward,K. 2001. Genetics Disease

Nondisjunction Meiosis

Chromosome Numeric Anomalies

Trisomy 21

Aneuplody

Euplody

• 69,XXX• Dyandric• Dygynic

Structural Abnormalities

Chromosomal findings in early miscarriages

40% apparently normal

60% abnormal:Trisomy (47 chromosomes – one extra) 30%

45,X (45 chromosomes – one missing) 10%

Triploidy (69 chromosomes – three sets) 10%

Tetraploidy (92 chromosomes – four sets) 5%

Other chromosome anomalies 5%(e.g. structural anomalies)

National Genetics Education and Development centre, 2009

Effect of Chromosomal Abnormalities

• Preimplantation – Implantation Losses

• Simpson, J, Carson, S, Glob. libr. women's med.,(ISSN: 1756-2228) 2013; DOI 10.3843/GLOWM.10319